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Pearch, Malcolm J. "Small mammal biodiversity in Nepal". Available from the University of Aberdeen Library and Historic Collections Digital Resources. Restricted: no access until June 2, 2014, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=26193.
Pełny tekst źródłaWong, Dorothy L. "Public perception of mammals and mammal conservation in Fairfax County, Virginia". Fairfax, VA : George Mason University, 2009. http://hdl.handle.net/1920/4588.
Pełny tekst źródłaVita: p. 160. Thesis director: E.C.M. Parsons. Submitted in partial fulfillment of the requirements for the degree of Master of Science in Environmental Science and Policy. Title from PDF t.p. (viewed Oct. 11, 2009). Includes bibliographical references (p. 152-159). Also issued in print.
Wang, Mengdong. "Studies on IgA Induction in Intestine and Mammary Glands of Mammals". Kyoto University, 2015. http://hdl.handle.net/2433/199345.
Pełny tekst źródła0048
新制・課程博士
博士(農学)
甲第19021号
農博第2099号
新制||農||1030(附属図書館)
学位論文||H27||N4903(農学部図書室)
31972
京都大学大学院農学研究科応用生物科学専攻
(主査)教授 久米 新一, 教授 祝前 博明, 教授 廣岡 博之
学位規則第4条第1項該当
Klanjšček, Tin. "Dynamic energy budgets and bioaccumulation : a model for marine mammals and marine mammal populations". Thesis, Massachusetts Institute of Technology, 2006. http://hdl.handle.net/1721.1/34623.
Pełny tekst źródła"June 2006."
Includes bibliographical references.
Energy intake of individuals affects growth of organisms and, therefore, populations. Persistent lipophilic toxicants acquired with the energy can bioaccumulate and harm individuals. Marine mammals are particularly vulnerable because of their large energy requirements, and transfer of energy and toxicants from mothers to their young during gestation and lactation. Dynamic energy budget (DEB) models for energy assimilation and utilization, coupled with pharmacokinetic models that calculate distribution of toxicants in individuals, can help investigate the vulnerability. In this dissertation I develop the first individual DEB model tailored specifically to marine mammals and couple it to a pharmacokinetic model for lipophilic toxicants. I adapt the individual model to the right whale and use it to analyze consequences of energy availability on individual growth, reproduction, bioaccumulation, and transfer of toxicants between generations. From the coupled model, I create an individual-based model (IBM) of a marine mammal population. I use it to investigate how interactions of food availability, exposure to toxicants, and maternal transfer of toxicants affect populations. I also present a method to create matrix population models from a general DEB model to alleviate some of the drawbacks of the IBM approach.
by Tin Klanjšček.
Ph.D.
Olsen, Morten Tange. "Molecular ecology of marine mammals". Doctoral thesis, Stockholms universitet, Institutionen för genetik, mikrobiologi och toxikologi, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-71166.
Pełny tekst źródłaAt the time of doctoral defence the following papers were unpublished and had a status as follows: Paper 2: Submitted; Paper 3:Submitted; Paper 4: Manuscript; Paper 5:Manuscript
Osborn, Scott Donald. "Adaptive heterothermy in desert mammals". Diss., The University of Arizona, 1991. http://hdl.handle.net/10150/185449.
Pełny tekst źródłaMamone, Mario Salvatore. "A comparative study of small mammal communities in riparian and upland mixed-conifer forest habitats /". View full-text version online through Southern Oregon Digital Archives, 1994. http://soda.sou.edu/awdata/040308a1.pdf.
Pełny tekst źródłaTypescript. Includes bibliographical references (leaves 73-80). Also available via Internet as PDF file through Southern Oregon Digital Archives: http://soda.sou.edu. Search Bioregion Collection.
Nousch, Marco Biotechnology & Biomolecular Sciences Faculty of Science UNSW. "The role of the translational regulator p97 in mammalian cells". Awarded by:University of New South Wales. Biotechnology & Biomolecular Sciences, 2008. http://handle.unsw.edu.au/1959.4/41445.
Pełny tekst źródłaFraser, Sheena Mary. "Mammals in Late Neolithic Orkney (with reference to mammal bone recovered from Links of Noltland, Westray)". Thesis, University of Edinburgh, 2015. http://hdl.handle.net/1842/26007.
Pełny tekst źródłaLiu, Yang Bankaitis Vytas A. "The Sac1 phosphoinositide phosphatases in mammals". Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2009. http://dc.lib.unc.edu/u?/etd,2847.
Pełny tekst źródłaTitle from electronic title page (viewed Jun. 4, 2010). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Cell and Developmental Biology." Discipline: Cell and Developmental Biology; Department/School: Medicine.
Keith, Mark. "Conservation assessment of South African mammals". Thesis, Connect to this title online, 2005. http://upetd.up.ac.za/thesis/available/etd-02142006-162024/.
Pełny tekst źródłaAung, Hnin Thanda. "The importance of epigenetics in mammals /". [St. Lucia, Qld.], 2006. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19398.pdf.
Pełny tekst źródłaMathis, Alexander. "The representation of space in mammals". Diss., lmu, 2012. http://nbn-resolving.de/urn:nbn:de:bvb:19-150029.
Pełny tekst źródłaNorthridge, Simon Patrick. "Interactions between fisheries and marine mammals". Thesis, Imperial College London, 1990. http://hdl.handle.net/10044/1/46474.
Pełny tekst źródłaThomson, Gabrielle Anne Biotechnology & Biomolecular Sciences Faculty of Science UNSW. "Retroelements as controlling elements in mammals". Awarded by:University of New South Wales. Biotechnology and Biomolecular Sciences, 2006. http://handle.unsw.edu.au/1959.4/26203.
Pełny tekst źródłaSouth, Andrew Brian. "Modelling the spatial distribution of mammals". Thesis, University of Newcastle Upon Tyne, 1999. http://hdl.handle.net/10443/175.
Pełny tekst źródłaWaddell, Victor Garry. "Higher level molecular systematics of mammals". Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394601.
Pełny tekst źródłaWragg, Fiona Catherine. "Biodiversity and conservation of African mammals". Thesis, Leeds Beckett University, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401768.
Pełny tekst źródłaHobson, L. "Dispersal and reproductive competition in mammals". Thesis, University of Liverpool, 2017. http://livrepository.liverpool.ac.uk/3005820/.
Pełny tekst źródłaZartman, David L. "INTRAVAGINAL TEMPERATURE TELEMETRY IN FEMALE MAMMALS". International Foundation for Telemetering, 1986. http://hdl.handle.net/10150/615280.
Pełny tekst źródłaThe four major management problems in female farm animals are identification, breeding timeliness, health monitoring and notice of parturition (delivery of young). Each of these has been solved with a single temperature-sensitive device placed in the vagina nonsurgically with a nylon anchor. Remote sensing of deep-body (core) temperature in female livestock is a major breakthrough in husbandry of farm animals and important zoo animals. Development of a patented, vaginal radio implant has enabled the remote sensing and automated processing of animal temperature data for females. A natural component of the system is automated identification of each female wearing a transmitter. The methodology of collecting and interpreting deep-body temperature depends upon using each female as her own basis of comparison. A temperature deviation of greater than 0.4* C relative to the average of the previous five day’s temperatures taken at approximately the same time of day indicates a significant physiological event. Ultimately, the optimum configuration of this system will invoke the creation of artificial intelligence or, at least, an expert system.
Belgard, Tildon Grant. "Comparative neurotranscriptomics in mammals and birds". Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:932c796c-d219-4df3-85cc-7d9db19d7d6b.
Pełny tekst źródłaCandille, Sophie Isabelle. "Genetics of pigmentation patterning in mammals /". May be available electronically:, 2007. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.
Pełny tekst źródłaFlewelling, Leanne J. "Vectors of brevetoxins to marine mammals". [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002675.
Pełny tekst źródłaHalliday, T. J. D. "The enigmatic evolutionary relationships of Palaeocene mammals and their relevance for the Tertiary radiation of placental mammals". Thesis, University College London (University of London), 2015. http://discovery.ucl.ac.uk/1469745/.
Pełny tekst źródłaMcCaslin, Lauren E. "Documenting Marine Mammal Behavior and Evaluating the Benefits and Consequences of Viewing Marine Mammals in Southcentral Alaska". TopSCHOLAR®, 2019. https://digitalcommons.wku.edu/theses/3128.
Pełny tekst źródłaXu, Xiufeng. "Studies of mammalian mitochondrial genomes with special emphasis on the perissodactyla". Lund : Lund University, 1996. http://catalog.hathitrust.org/api/volumes/oclc/38161173.html.
Pełny tekst źródłaMartínez, Marchal Ana. "Regulation of the oocyte pool in mammals". Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667797.
Pełny tekst źródłaDuring mammalian oogenesis, oogonia proliferate forming the so-called cysts. The oogonia enter meiosis progressing through prophase I and the cysts break down concomitantly to massive perinatal oocyte death. During meiotic prophase I, double strand breaks (DSBs) are induced throughout the genome and repaired by homologous recombination to promote the synapsis of the homologous chromosomes. In response to errors in these processes, different response pathways are activated triggering cell cycle arrest or even apoptosis. The DNA damage response (DDR) is activated in response of meiocytes with recombination failure in the recombination checkpoint; while errors in synapsis trigger the synapsis checkpoint. We aimed to characterize the roles of the DDR and synapsis checkpoint in mammalian oogenesis. Contrary to what occurs in spermatocytes, oocytes present high numbers of unrepaired DSBs at pachynema, at the time of the massive oocyte death and cyst breakdown. In order to know if the recombination checkpoint participates in the regulation of the oocyte number in mammals, we analyzed the presence of DSBs, the oocyte number in both perinatal and adult females, the cyst breakdown, the formation of follicles and the reproductive lifespan using control and mutant mice for the effector kinase of the DNA damage response pathway, CHK2. Our data revealed the involvement of CHK2 in the regulation of the oocyte number but only in fetal ovaries prior to birth, raising the question of a possible alternative regulator acting just after birth. Our studies using in vitro ovarian cultures using inhibitors, suggest that CHK1 may compensate the loss of CHK2 perinatally in vivo. Thus, revealing that the DDR pathway controls the oocyte number in mammals. Furthermore, we found an increased number of oocytes in elder Chk2 mutant females suggesting that the DDR controls the reproductive lifespan extension in mammals. Finally, we studied the possible involvement of TRIP13 in the synapsis checkpoint. The protein TRIP13 is required for recombination, but it is also needed for the synapsis of sex chromosomes and the sex body formation. Thus, suggesting a possible role in the synapsis checkpoint. We analyzed the oocyte number in females from Spo11-/- Trip13mod/mod and Dmc1-/- Chk2-/- Trip13mod/mod ovaries in order to infer if TRIP13 is required to implement the synapsis checkpoint in females. Our data revealed a rescue in the number of oocytes in the triple mutant, but not in the double mutant. These results leave open the possibility of a participation of TRIP13 in the synapsis checkpoint, but as an alternative, they could be compatible with a possible role of TRIP13 regulating the DSB repair pathway choice.
Carter, Caroline Jane. "Tidal energy, underwater noise & marine mammals". Thesis, University of the Highlands and Islands, 2008. https://pure.uhi.ac.uk/portal/en/studentthesis/tidal-energy-underwater-noise-and-marine-mammals(9963d662-76e1-4e70-a3ac-e18a96b23101).html.
Pełny tekst źródłaZadissa, Amonida, i n/a. "Inferring transcriptional regulation in mammals using bioinformatics". University of Otago. Department of Biochemistry, 2007. http://adt.otago.ac.nz./public/adt-NZDU20070614.111340.
Pełny tekst źródłaScott, Craig Smith. "Middle Paleocene mammals from Calgary, Alberta, Canada". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ60494.pdf.
Pełny tekst źródłaLucke, Klaus [Verfasser]. "Auditory studies on marine mammals / Klaus Lucke". Kiel : Universitätsbibliothek Kiel, 2009. http://d-nb.info/1019811455/34.
Pełny tekst źródłaReid, Ian Duncan. "Transcription factor binding site turnover in mammals". Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18293.
Pełny tekst źródłaLes sites de fixation des facteurs de transcription (TFBS) sont souvent, mais pas toujours, conservés pendant l'évolution. Afin de mieux comprendre leur évolution, j'ai examiné les cas de non-conservation de 1120 TFBS connus chez l'homme et la souris dans les génomes d'onze mammifères et les génomes reconstruits de leurs ancêtres. De nouveaux TFBS se sont développés fréquemment, même près des sites ancestraux conservés, mais le gain d'un site était significativement plus probable quand un site ancestral avait disparu. 165 TFBS de l'homme et 113 TFBS de la souris ont évolué de novo depuis leur divergence de l'ancêtre boreoeuthérien et sont absents des autres lignées. Les TFBS putatifs et les séquences qui diffèrent des TFBS par une substitution sont plus abondants qu'attendu par hasard auprès des TFBS connus. L'enrichissement et rassemblement apparents des TFBS faibles sont des résultats des variations locales dans l'abondance de C et G.
Thompson, Amy. "Correlates and consequences of heterothermy in mammals". Thesis, McGill University, 2012. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=107856.
Pełny tekst źródłaLes animaux endothermiques sont capables d'utiliser leur chaleur interne afin de réguler précisément leur température corporelle à un niveau élevé, pourtant il y une gamme considérable dans le degré de variation en température corporelle (hétérothermie) chez les endothermes. Dans cette thèse, j'utilise deux méthodes différentes pour adresser les causes et conséquences de l'hétérothermie chez les mammifères, reflétant un compromis entre les avantages fonctionnels et les désavantages énergétiques de l'endothermie. Je mène premièrement une analyse empirique inter-espèce de l'hétérothermie chez les mammifères rapportée dans la littérature. L'hétérothermie est considérée comme trait continu pour examiner les facteurs qui prédisent le gradient hétérothermique chez 545 espèces. L'hétérothermie diminue avec la masse corporelle et augmente vers les pôles, et les amasseurs de nourriture sont moins hétérothermiques que les non-ammasseurs. Une fois que ces effets allométriques, latitudinaux, et comportementaux sont inclus, la phylogénie avait encore une influence forte sur le degré d' hétérothermie. Dans mon deuxième chapitre, j'examine les désavantages comportementaux de la torpeur, un cas spécial d'hétérothermie dans lequel les individus montrent une réduction marquée de leur température corporelle et de leur métabolisme. Cette recherche a été menée en captivité sur les tamias rayés (Tamias striatus), reconnus pour manifester des degrés de torpeur traversant la plupart de la gamme d'hétérothermie exprimée par les mammifères en générale. Pour examiner les désavantages comportementaux de la torpeur comme une explication potentielle de cette variation, la performance individuelle a été évaluée avant et durant l'hibernation à l'aide d'un test de l'arène et d'un test de labyrinthe radial. Les résultats ont montré que l'habituation dans le test de l'arène était affectée négativement par la torpeur, particulièrement la torpeur profonde, mais la performance dans le labyrinthe radiale, testée plus tard dans la période d'éveil, était moins affectée. Ainsi, l'expression de la torpeur affecte clairement le comportement, mais ces effets sont très transitoires et ont alors probablement peu de conséquences à long terme sur l'aptitude de l'individu. Les mammifères en générale sont caractérisés par une vaste variation, inter- et intra-espèce, dans le degré d'hétérothermie et les espèces occupants les climats froids et se nourrissants de ressources éphémères sont caractérisées par le plus d'hétérothermie. En expliquant pourquoi il n'y a pas plus d'individus et d'espèces qui exploitent les avantages énergétiques de l'hétérothermie de haute amplitude, la recherche en captivité suggère que les désavantages immédiats de la torpeur sur la fonction des endothermes peuvent être plus importants que ses effets à long terme.
Poirier, Madeleine. "The expression of CDP/Cux in mammals /". Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=79114.
Pełny tekst źródłaBarker, Emily Ngaire. "Molecular studies on haemotropic mycoplasmas of mammals". Thesis, University of Bristol, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.539767.
Pełny tekst źródłaMohamed, H. A. "Studies on protozoan parasites of small mammals". Thesis, University of Salford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.374504.
Pełny tekst źródłaMerkin, Jason Jay. "The evolution of mRNA splicing in mammals". Thesis, Massachusetts Institute of Technology, 2014. http://hdl.handle.net/1721.1/89945.
Pełny tekst źródłaTitle as it appears in MIT commencement exercises program, June 6, 2014: The evolution of mRNA splicing in mammalian tissues Cataloged from PDF version of thesis.
Includes bibliographical references (pages 167-172).
In this thesis, I describe investigations into the evolution of splicing in mammals. I first investigate a small class of alternative splicing events, tandem splice sites, and show how they are used to introduce and remove coding sequence in a species-specific manner. I then describe the generation and analysis of a large RNA-seq dataset from 9 matched tissues in 5 species, with the aim to investigate the evolution of splicing in mammals. I first investigate the evolution of exons that predate the most ancient divergence of species studied, finding that their splicing is frequently poorly conserved. For a subset of these exons, I identify unique regulatory properties and provide evidence linking alternative splicing to phosphorylation potential of proteins. I then consider sources of novel exons, in these species. I use these and other published data to identify one way in which splicing of novel exons impacts the biology of the cell. I also present evidence implicating genomic indels in exon creation and splicing variation.
by Jason Jay Merkin.
Ph. D.
Guttman, Mitchell. "Functional large non-coding RNAs in mammals". Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/72806.
Pełny tekst źródłaCataloged from PDF version of thesis.
Includes bibliographical references.
It is now clear that RNA is more than a messenger and performs vast and diverse functions. These functional RNAs include the ribosomal, transfer, and splicing-associated RNAs along with a cast of tiny RNAs, including microRNAs and other families. In addition to these classic examples, there were a handful of known functional large ncRNAs that play important biological roles. To identify additional functional large ncRNAs we exploited a chromatin signature of actively transcribed genes to define discrete transcriptional units that do not overlap any known proteincoding genes. Using this approach we identified -3,500 transcriptional units in the human and mouse genomes that produce multi-exonic RNAs that lack any coding potential. We termed these large intergenic non-coding RNAs (lincRNAs). Importantly, these lincRNAs exhibit strong purifying selection across various mammalian genomes. To determine whether the lincRNA transcripts themselves have biological functions, we undertook systematic loss-of-function experiments on most lincRNAs defined in mouse embryonic stem cells (ESCs). We showed that knockdown of the vast majority of ESC-expressed lincRNAs has a strong effect on gene expression patterns in ESCs, of comparable magnitude to that seen for the well-known ESC regulatory proteins. We identify dozens of lincRNAs that upon loss-of-function cause an exit from the pluripotent state and dozens of additional lincRNAs that, while not essential for the maintenance of pluripotency, act to repress lineage-specific gene expression programs in ESCs. Despite their important functional roles, how lincRNAs exert their influence was unknown. We showed that many lincRNAs physically interact with the Polycomb Repressive Complex. We systematically analyzed chromatin-modifying proteins that have been shown to play critical roles in ESCs and identified 11 additional chromatin complexes that physically interact with the ESC lincRNAs. Altogether, we found that -30% of the ESC lincRNAs are associated with multiple chromatin complexes. These interactions are important for proper regulation of gene expression programs in ES cells. Our data suggests a model whereby a distinct set of lincRNAs is transcribed in a cell type and interacts with ubiquitous regulatory protein complexes to give rise to cell-type-specific RNA-protein complexes that coordinate cell-type specific gene expression programs.
by Mitchell Guttman.
Ph.D.
Eyre-Walker, Adam C. "Studies of synonymous codon evolution in mammals". Thesis, University of Edinburgh, 1992. http://hdl.handle.net/1842/14820.
Pełny tekst źródłaMilligan, Adam D. S. "The lateralisation of emotion in social mammals". Thesis, University of Stirling, 2013. http://hdl.handle.net/1893/21171.
Pełny tekst źródłaAl, Jothery Aqeel Handil Tarish. "Lactation and oxidative stress in small mammals". Thesis, University of Aberdeen, 2014. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=215095.
Pełny tekst źródłaMoon, Derek. "Small mammals in disturbed tallgrass prairie landscapes". Thesis, Kansas State University, 2012. http://hdl.handle.net/2097/13345.
Pełny tekst źródłaDepartment of Biology
Jack Cully, Jr.
Disturbance is defined as any discrete event that disrupts ecosystem, community, or population structure and changes resources, substrate availability, or the physical environment. Habitat use by an organism is based on its perception of where to maximize its own fitness, and can be altered in response to disturbance-induced changes in resources, substrate, or physical features modified by disturbance. Disturbance-induced changes to vegetation structure reshape a small mammal’s surrounding physical environment and/or resources, and may influence its utilization of an area. Effective wildlife and resource management is dependent on a thorough understanding of how individual species and communities utilize their surroundings and how disturbance affects a species’ response to changes in its surroundings. We investigated seasonal habitat associations of three small mammal species and for overall species diversity across a gradient of military combat-vehicle disturbance intensities at the Fort Riley Military Reservation, Kansas. Deer mouse (Peromyscus maniculatus) abundance did not vary across a categorical gradient of disturbance created by military-combat vehicles, regardless of season. Western harvest mouse (Reithrodontomys megalotis) abundance was associated with more highly disturbed areas irrespective of season. Prairie vole (Microtus ochrogaster) abundance was associated with habitat that was less disturbed in the spring but more highly disturbed in the fall. Shannon diversity of the small mammal community was higher in the more highly disturbed areas regardless of season. This research shows that small mammals respond to disturbances created by military training with combat vehicles in a species-specific manner, and indicates that there may be differences in the effects of military training versus natural or agricultural disturbances on the abundance and diversity of small mammals. This is an important consideration given that the Department of Defense manages more than 12 million ha of land in the United States, and is charged under the Sikes Act with conserving natural resources on these lands, including biological diversity. Thus, the findings of other ecological research on the effects of disturbance on small mammals may not be directly applicable to the types of disturbances that occur on military lands, which underscores the need for further research on the specific effects of military-training activities on species’ responses.
Mota, Martorell Natàlia. "Oxidative stress homeostasis and longevity in mammals". Doctoral thesis, Universitat de Lleida, 2021. http://hdl.handle.net/10803/672775.
Pełny tekst źródłaLas especies más longevas han evolucionado disminuyendo la producción endógena de especies reactivas de oxígeno y proveyéndose de estructuras resistentes a la oxidación. Por lo tanto, aquellas especies que viven más disfrutan de mitocondrias metabólicamente más eficientes y estructuralmente más estables. De hecho, características fenotípicas de la longevidad incluyen la reducción del contenido del complejo I y de amino ácidos sulfurados. Por lo tanto, la activad de determinadas vías de señalización intracelular juegan un papel clave regulando la expresión de genes asociados a un fenotipo longevo. En este contexto, esta tesis pretende determinar i) la modulación de determinadas subunidades del complejo I asociada a la longevidad; ii) los cambios en el contenido de amino acido sulfurados y de sus intermediarios metabólicos en tejidos post-mitóticos y iii) plasma de especies más longevas; iv) la regulación del contenido de distintos elementos específicos del complejo 1 de mTOR en términos de longevidad; y v) la existencia de un perfil metabólico asociado a humanos de longevidad extrema. Los resultados obtenidos muestran la existencia de perfiles metabólicos asociados a la longevidad de las especies que, en algunos casos, son diferentes a aquellos perfiles asociados a la longevidad individual. Además, las especies más longevas han evolucionado disminuyendo el contenido de determinadas subunidades del complejo I que podrían ser responsables de la menor producción de especies reactivas de oxígeno. Por otra parte, existen factores genéticos que podrían determinar la actividad basal de mTOR, y que podrían, al menos en parte, explicar el fenotipo asociado a la longevidad. Por lo tanto, parece que lograr una mayor longevidad implica una adaptación metabólica y estructural.
Long-lived species have evolved by decreasing the rate of endogenous reactive oxygen species production and providing them of oxidation-resistant structures. Hence, species that live longer benefit from metabolically efficient and structurally stable mitochondria. In fact, phenotypic traits of longevity include reduced content of complex I and sulphur-containing amino acids. Then, the activity of selected intracellular signalling pathways plays a key role regulating the expression of genes associated to a longevity phenotype. In this context, this thesis aims to determine i) the modulation of specific complex I subunits associated to longevity; ii) the changes on sulphur amino acids content and its metabolic intermediates in post-mitotic tissues and ii) plasma from long-lived species; iv) the content regulation of the different mTOR complex 1 specific forming elements in terms of longevity; and v) the existence of a metabolic profile associated to human extreme longevity. The obtained results reveal the existence of metabolic profiles associated to species longevity that, in some cases, differ from those profile associated to individual longevity. Furthermore, longer lived species have evolved reducing the content of specific complex 1 subunits that might be responsible for the limited reactive oxygen species production. Otherwise, genetic factors that might determine the basal activity of mTORC1 exist, and that could, at least In part, explain the longevity associated phenotype. Thus, it seems that the achievement of an extended longevity implies a metabolic and structural adaptation.
Omori, Taketo. "Biochemical studies of novel glycerophospholipids in mammals". Kyoto University, 2009. http://hdl.handle.net/2433/126535.
Pełny tekst źródła0048
新制・課程博士
博士(農学)
甲第14874号
農博第1786号
新制||農||975(附属図書館)
学位論文||H21||N4489(農学部図書室)
27296
UT51-2009-K670
京都大学大学院農学研究科応用生命科学専攻
(主査)准教授 栗原 達夫, 教授 喜多 恵子, 教授 植田 充美
学位規則第4条第1項該当
Cooper, Natalie. "Phylogenetic approaches for studying competition in mammals". Thesis, Imperial College London, 2009. http://hdl.handle.net/10044/1/4356.
Pełny tekst źródłaMcDonald, Peter James. "Refuges for declining mammals in dryland Australia". Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/19905.
Pełny tekst źródłaHallberg, Karen Irene. "Information in a long-distance vocal signal chorus howling in the coyote (Canis latrans) /". Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1189626727.
Pełny tekst źródłaCelik, Melina Anouche. "Tracing the evolution of Australasian mammals: Integrating morphological, palaeontological and molecular data". Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/135716/1/Melina%20Anouche_Celik_Thesis.pdf.
Pełny tekst źródłaCan, Ozgun Emre. "Camera Trapping Large Mammals In Yenice Forest Habitats: A Feasibility Study For Camera Trapping Large Mammals In Yenice Forests, Turkey". Phd thesis, METU, 2008. http://etd.lib.metu.edu.tr/upload/3/12609974/index.pdf.
Pełny tekst źródłak during January-May 2006. The camera trap survey confirmed the presence of grey wolf (Canis lupus), brown bear (Ursus arctos), wildcat (Felis silvestris), red fox (Vulpes vulpes), badger (Meles meles), pine marten (Martes martes), roe deer (Capreolus capreolus) and wild boar (Sus scrofa) in the study area. The camera trap survey also revealed the presence of jackal (Canis aureus) and brown hare (Lepus europaeus), whose presence were not known by people living and working in the area. Contrary to the local belief, neither camera trapping survey nor ground survey confirmed the presence of lynx (Lynx lynx) in Yaylacik Research Forest. The wolf was observed to be crepuscular and the wildcat showed a diurnal activity pattern. Wildcat seemed to avoid other carnivores spatially and temporally. Simulation studies suggested that camera trap surveys should last 14 days for wolf, 13 days for wildcat, 10 days for pine marten, and 11 days for roe deer, while it is advisable to conduct longer surveys, probably 15-20 days, for wild boar, red fox and brown bears. The estimated population size for wildcat was 9 (SE=2.28227) with 95% confidence interval of 9 to 25 in the study area. A minimum of 6 brown bears were present in the study area. Our study indicated that the local knowledge about the presence of wildlife should be considered by researchers, but it cannot replace scientific surveys conducted by field biologists. This study was the first attempt to assess the presence, relative abundance, activity patterns and diversity of multiple mammal species by the use of camera trapping methodology in Turkey. The results suggest that camera trap surveys have the potential for gathering wildlife data at larger scales in Turkey, where information gap on large mammals is an obstacle for effective management and conservation of mammals.
Li, Na. "Critical role of transcription cofactor PC4 in mammals". Diss., kostenfrei, 2010. http://d-nb.info/1001408519/34.
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