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1
Engwirda, Anthony, i N/A. "Self-Reliance Guidelines for Large Scale Robot Colonies". Griffith University. Griffith School of Engineering, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20070913.100750.
Pełny tekst źródłaStreszczenie:
A Large Scale Robot Colony (LSRC) is a complex artifact comprising of a significant population of both mobile and static robots. LSRC research is in its literary infancy and it is therefore necessary to rely upon external fields for the appropriate framework, Multi Agent Systems (MAS) and Large Scale Systems (LSS). At the intersection of MAS, LSS and LSRC exist near identical issues, problems and solutions. If attention is paid to coherence then solution portability is possible. The issue of Self-Reliability is poorly addressed by the MAS research field. Disparity between the real world and simulation is another area of concern. Despite these deficiencies, MAS and LSS are perceived as the most appropriate frameworks. MAS research focuses on three prime areas, cognitive science, management and interaction. LSRC is focused on Self-Sustainability, Self-Management and Self-Organization. While LSS research was not primarily intended for populations of mobile robots, it does address key issues of LSRC, such as effective sustainability and management. Implementation of LSRC that is based upon the optimal solution for any one or two of the three aspects will be inferior to a coherent solution based upon all three. LSRCs are complex organizations with significant populations of both static and mobile robots. The increase in population size and the requirement to address the issue of Self-Reliance give rise to new issues. It is no longer sufficient to speak only in terms of robot intelligence, architecture, interaction or team behaviour, even though these are still valid topics. Issues such as population sustainability and management have greater significance within LSRC. As the size of a robot populations increases, minor uneconomical decisions and actions inhibit the performance of the population. Interaction must be made economical within the context of the LSRC. Sustainability of the population becomes significant as it enables stable performance and extended operational lifespan. Management becomes significant as a mechanism to direct the population so as to achieve near optimal performance. The Self-Sustainability, Self-Management and Self-Organization of LSRC are vastly more complex than in team robotics. Performance of the overall population becomes more significant than individual or team achievement. This thesis is a presentation of the Cooperative Autonomous Robot Colony (CARC) architecture. The CARC architecture is novel in that it offers a coherent baseline solution to the issue of mobile robot Self-Reliance. This research uses decomposition as a mechanism to reduce problem complexity. Self-Reliance is decomposed into Self-Sustainability, Self-Management, and Self-Organization. A solution to the issue of Self-Reliance will comprise of conflicting sub-solutions. A product of this research is a set of guidelines that manages the conflict of sub-solutions and maintains a coherent solution. In addressing the issue of Self-Reliance, it became apparent that Economies of Scale, played an important role. The effects of Economies of Scale directed the research towards LSRCs. LSRCs demonstrated improved efficiency and greater capability to achieve the requirements of Self-Reliance. LSRCs implemented with the CARC architecture would extend human capability, enabling large scale operations to be performed in an economical manner, within real world and real time environments, including those of a remote and hostile nature. The theory and architecture are supported using published literature, experiments, observations and mathematical projections. Contributions of this work are focused upon the three pillars of Self-Reliance addressed by CARC: Self-Sustainability, Self-Management and Self-Organization. The chapter on Self-Sustainability explains and justifies the relevance of this issue, what it is, why it is important and how it can be achieved. Self-Sustainability enables robots to continue to operate beyond disabling events by addressing failure and routine maintenance. Mathematical projections are used to compare populations of non-sustained and sustained robots. Computer modeling experiments are used to demonstrate the feasibility of Self-Sustainability, including extended operational life, the maintenance of optimal work flow and graceful physical degradation (GPD). A detailed explanation is presented of Sustainability Functions, Colony Sites, Static Robot Roles, Static Robot Failure Options, and Polymorphism. The chapter on Self-Management explores LSS research as a mechanism to exert influence over a LSRC. An experimental reactive management strategy is demonstrated. This strategy while limited does indicate promising potential directions for future research including the Man in the Loop (MITL) strategy highly desired by NASA JPL for off world command and control of a significant robot colony (Huntsberger, et. al., 2000). Experiments on Communication evaluate both Broadcast Conveyance (BC) and Message Passing Conveyance (MPC). These experiments demonstrate the potential of Message Passing as a low cost system for LSRC communication. Analysis of Metrics indicates that a Performance Based Feedback Method (PBFM) and a Task Achievement Method (TAM) are both necessary and sufficient to monitor a LSRC. The chapter on Self-Organization describes a number of experiments, algorithms and protocols on Reasoning Robotics, a minor variant of Reactive Robotics. Reasoning Robotics utilizes an Event Driven Architecture (EDA) rather than a Stimulus Driven Architecture (SDA) common to Reactive Robotics. Enhanced robot performance is demonstrated by a combination of EDA and environmental modification enabling stigmergy. These experiments cover Intersection Navigation with contingency for Multilane Intersections, a Radio Packet Controller (RPC) algorithm, Active and Passive Beacons including a communication protocol, mobile robot navigation using Migration Decision Functions (MDFs), including MDF positional errors. The central issue addressed by this thesis is the production of Self-Reliance guidelines for LSRCs. Self-Reliance is perceived as a critical issue in advancing the useful and productive applications for LSRCs. LSRCs are complex with many issues in related fields of MAS and LSS. Decomposition of Self-Reliance into Self-Sustainability, Self-Management and Self-Organization were used to aid in problem understanding. It was found that Self-Sustainability extends the operational life of individual robots and the LSRC. Self-Management enables the exertion of human influence over the LSRC, such that the ratio of humans to robots is reduced but not eliminated. Self-Organization achieves and enhances performance through a routine and reliable LSRC environment. The product of this research was the novel CARC architecture, which consists of a set of Self-Reliance guidelines and algorithms. The Self-Reliance guidelines manage conflict between optimal solutions and provide a framework for LSRC design. This research was supported by literature, experiments, observations and mathematical projections.
2
Engwirda, Anthony. "Self-Reliance Guidelines for Large Scale Robot Colonies". Thesis, Griffith University, 2007. http://hdl.handle.net/10072/368079.
Pełny tekst źródłaStreszczenie:
A Large Scale Robot Colony (LSRC) is a complex artifact comprising of a significant population of both mobile and static robots. LSRC research is in its literary infancy and it is therefore necessary to rely upon external fields for the appropriate framework, Multi Agent Systems (MAS) and Large Scale Systems (LSS). At the intersection of MAS, LSS and LSRC exist near identical issues, problems and solutions. If attention is paid to coherence then solution portability is possible. The issue of Self-Reliability is poorly addressed by the MAS research field. Disparity between the real world and simulation is another area of concern. Despite these deficiencies, MAS and LSS are perceived as the most appropriate frameworks. MAS research focuses on three prime areas, cognitive science, management and interaction. LSRC is focused on Self-Sustainability, Self-Management and Self-Organization. While LSS research was not primarily intended for populations of mobile robots, it does address key issues of LSRC, such as effective sustainability and management. Implementation of LSRC that is based upon the optimal solution for any one or two of the three aspects will be inferior to a coherent solution based upon all three. LSRC’s are complex organizations with significant populations of both static and mobile robots. The increase in population size and the requirement to address the issue of Self-Reliance give rise to new issues. It is no longer sufficient to speak only in terms of robot intelligence, architecture, interaction or team behaviour, even though these are still valid topics. Issues such as population sustainability and management have greater significance within LSRC. As the size of a robot populations increases, minor uneconomical decisions and actions inhibit the performance of the population. Interaction must be made economical within the context of the LSRC. Sustainability of the population becomes significant as it enables stable performance and extended operational lifespan. Management becomes significant as a mechanism to direct the population so as to achieve near optimal performance. The Self-Sustainability, Self-Management and Self-Organization of LSRC are vastly more complex than in team robotics. Performance of the overall population becomes more significant than individual or team achievement. This thesis is a presentation of the Cooperative Autonomous Robot Colony (CARC) architecture. The CARC architecture is novel in that it offers a coherent baseline solution to the issue of mobile robot Self-Reliance. This research uses decomposition as a mechanism to reduce problem complexity. Self-Reliance is decomposed into Self-Sustainability, Self-Management, and Self-Organization. A solution to the issue of Self-Reliance will comprise of conflicting sub-solutions. A product of this research is a set of guidelines that manages the conflict of sub-solutions and maintains a coherent solution. In addressing the issue of Self-Reliance, it became apparent that Economies of Scale, played an important role. The effects of Economies of Scale directed the research towards LSRC’s. LSRC’s demonstrated improved efficiency and greater capability to achieve the requirements of Self-Reliance. LSRC’s implemented with the CARC architecture would extend human capability, enabling large scale operations to be performed in an economical manner, within real world and real time environments, including those of a remote and hostile nature. The theory and architecture are supported using published literature, experiments, observations and mathematical projections. Contributions of this work are focused upon the three pillars of Self-Reliance addressed by CARC: Self-Sustainability, Self-Management and Self-Organization. The chapter on Self-Sustainability explains and justifies the relevance of this issue, what it is, why it is important and how it can be achieved. Self-Sustainability enables robots to continue to operate beyond disabling events by addressing failure and routine maintenance. Mathematical projections are used to compare populations of non-sustained and sustained robots. Computer modeling experiments are used to demonstrate the feasibility of Self-Sustainability, including extended operational life, the maintenance of optimal work flow and graceful physical degradation (GPD). A detailed explanation is presented of Sustainability Functions, Colony Sites, Static Robot Roles, Static Robot Failure Options, and Polymorphism. The chapter on Self-Management explores LSS research as a mechanism to exert influence over a LSRC. An experimental reactive management strategy is demonstrated. This strategy while limited does indicate promising potential directions for future research including the Man in the Loop (MITL) strategy highly desired by NASA JPL for off world command and control of a significant robot colony (Huntsberger, et. al., 2000). Experiments on Communication evaluate both Broadcast Conveyance (BC) and Message Passing Conveyance (MPC). These experiments demonstrate the potential of Message Passing as a low cost system for LSRC communication. Analysis of Metrics indicates that a Performance Based Feedback Method (PBFM) and a Task Achievement Method (TAM) are both necessary and sufficient to monitor a LSRC. The chapter on Self-Organization describes a number of experiments, algorithms and protocols on Reasoning Robotics, a minor variant of Reactive Robotics. Reasoning Robotics utilizes an Event Driven Architecture (EDA) rather than a Stimulus Driven Architecture (SDA) common to Reactive Robotics. Enhanced robot performance is demonstrated by a combination of EDA and environmental modification enabling stigmergy. These experiments cover Intersection Navigation with contingency for Multilane Intersections, a Radio Packet Controller (RPC) algorithm, Active and Passive Beacons including a communication protocol, mobile robot navigation using Migration Decision Functions (MDF’s), including MDF positional errors. The central issue addressed by this thesis is the production of Self-Reliance guidelines for LSRC’s. Self-Reliance is perceived as a critical issue in advancing the useful and productive applications for LSRC’s. LSRC’s are complex with many issues in related fields of MAS and LSS. Decomposition of Self-Reliance into Self-Sustainability, Self-Management and Self-Organization were used to aid in problem understanding. It was found that Self-Sustainability extends the operational life of individual robots and the LSRC. Self-Management enables the exertion of human influence over the LSRC, such that the ratio of humans to robots is reduced but not eliminated. Self-Organization achieves and enhances performance through a routine and reliable LSRC environment. The product of this research was the novel CARC architecture, which consists of a set of Self-Reliance guidelines and algorithms. The Self-Reliance guidelines manage conflict between optimal solutions and provide a framework for LSRC design. This research was supported by literature, experiments, observations and mathematical projections.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Griffith School of Engineering
Faculty of Engineering and Information Technology
Full Text
3
Malheiros, Dorotea Starling. "Estudo descritivo do trauma ortopédico em crianças e adolescentes atendidas em centro de atendimento nível II". Universidade Federal de Minas Gerais, 2009. http://hdl.handle.net/1843/LSPC-8RWH9F.
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Between April 27th 1995 and April 26th 2005, patients with external cause lesions seen at the pediatric orthopedic outpatient clinic of the Maria Amelia Lins Hospital were studied. The objective was to identify the characteristics, patients profile through the variables: age, gender, trauma mechanism, side, topographic localization, associated injuries and compare the epidemiological results with the literature findings. The inclusion criterias were: have a external cause lesion, find the medical records with the appropriate research informations and have open physes. In the above mentioned period 2472 patients were identified, of which 1199 fitted the inclusion criterias. Patients identification and lesion characteristics were taken from the medical records. Age was count in absolute years. Mechanism of trauma were grouped in falls, traffic accidents, direct trauma, others and without information. Thetypes of lesions were divided in amputation, fractures, epiphysiolises, luxations, head trauma, contusions, internal organs injuries, face injuries, and others. Fractures, fracture-luxation, epiphysiolises and luxations were, also, classified as open or closed. Topographic localizationswere classified in relation to bony segments. Patients were grouped in general population, isolated injuries, multiple lesions that had more then one segment and/or of other organs involved. The orthopedic injuries that required more secondary attention were described asprincipal. From the general sample, 838 (68.9%) patients had isolated injuries, 361 (30.1%) patients had 884 multiple lesions. Mean age was 7.6±3.4 years. Masculine gender and the left side predominated. In the isolated injuries the upper limbs were more affected while lowerlimbs were more affected in multiple lesions. The most common trauma mechanisms in general and isolated groups, were falls (39.0% e 44,3%) and traffic accidents in multiple injuries (42,7%). Fracture was the most frequent type of lesion was (73,0% - general sample, 85,3% - isolated injuries and 61,1% - in multiple injuries). Elbow fractures (24%) were the most common topographic localization among the isolated injuries, while leg fractures (12,9%) were the most common among the multiple injuries. One associated injury was seen in 67.% of the multiple lesions 24.3% had two, 5.3% had three and 3.3% had four. Mainly the associationamong elbow fractures and forearm fractures with 25 cases. In conclusion, the descriptive characteristics were the same as the literature. The isolated injury patients´ profile is: boys, inschool age, victims of fall, with upper limb long bone closed fractures. The multiple injury patients´ profile is: boys, at school age, victims of traffic accidents, with lower limb long bone fractures associated with other injuries. Protocols development and introduction are of essential for bias exclusion and comparison in this type of study.No período de 27/04/1995 a 26/04/2005, estudou-se as vítimas de lesões de causa externa atendidas no Ambulatório de Ortopedia Pediátrica do Hospital Maria Amélia Lins. Os objetivos foram identificar as características das lesões ortopédicas; o perfil dos pacientes quanto às variáveis: idade, gênero, mecanismo de trauma, tipo de lesão, lado, localização topográfica e afecções associadas; e comparar os dados epidemiológicos com os da literatura. Foram critérios de inclusão ser vítimas de lesões de causa externa, a localização do prontuário, oregistro nele dos dados necessários à pesquisa, e a presença de fise aberta. No período, foram identificados 2472 pacientes, dos quais 1199 se encaixavam nos critérios de inclusão. Foram extraídos dos prontuários dados de identificação do paciente e dados relativos às lesões observadas. A variável idade foi registrada em números absolutos de anos de vida. Os mecanismos de trauma foram agrupados em acidentes de trânsito; quedas; trauma direto;outros e sem relato. Os tipos de lesões foram subdivididos em amputações; fraturas; epifisiólise; luxações; traumatismo cranioencefálico; contusões; lesões de órgãos internos; lesões de face; e outras lesões. As fraturas, fraturas-luxações, as epifisiólises e luxações foram classificadas, quanto à exposição, em expostas e fechadas. A localização topográfica das lesões foi classificada em relação aos segmentos ósseos nos quais ocorreram. Os pacientes foram agrupados em amostra geral, portadores de lesões isoladas e portadores de lesões múltiplas, considerando-se essas últimas as que acometeram mais de um segmento do esqueleto e/ou lesões de outros órgãos ou sistemas. A lesão musculoesquelética que necessitou mais atenção secundária foi descrita como lesão principal. Da amostra geral, 838 (68,9%) pacientes tiveram lesões isoladas e 361 (30,1%) presentaram 884 lesões. A média de idade foi 7,6±3,4 anos. Houve predomínio do gênero masculino e do lado esquerdo. Os membros superiores preponderaram nas lesões isoladas e os membros inferiores nas lesões múltiplas. O mecanismo de trauma mais comum na amostra geral e no grupo lesões isoladas foi a queda(39,0% e 44,3% respectivamente) e, nas lesões múltiplas, foi o acidente de trânsito (42,7%). O tipo de lesão mais frequente foi a fratura (73,0% - amostra geral, 85,3% - lesões isoladas e 61,1% - nas múltiplas). Quanto à localização topográfica, nas lesões isoladas predominaram asfraturas de cotovelo (24%) e, nas lesões múltiplas, as fraturas dos ossos da perna (12,9%). Nos portadores de lesões múltiplas, 67,1% tinham uma lesão associada, 24,3% duas, 5,3% três, e 3,3% quatro, com destaque para as fraturas de cotovelo com as fraturas de antebraço (25 casos). Concluiu-se que as características descritivas se encontram em conformidade com aliteratura. Os portadores de lesões isoladas podem ser definidos como meninos em idade escolar, vítimas de queda, apresentando fratura fechada de osso longo do membro superior. Os portadores de lesões múltiplas caracterizaram-se por ser meninos, em idade escolar, vítimas de acidente de trânsito apresentando fratura de ossos do membro inferior acompanhada de outra lesão. O desenvolvimento e a implantação de protocolos deatendimento são de fundamental importância para a eliminação de vieses na coleta de dados nesse tipo de estudo.
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Zorzi, Giorgia. "Coordination and gapping in Catalan Sign Language (LSC)". Doctoral thesis, Universitat Pompeu Fabra, 2018. http://hdl.handle.net/10803/665045.
Pełny tekst źródłaStreszczenie:
This thesis gives a description and a syntactic analysis for coordination and gapping in conjunction in Catalan Sign Language (LSC) within the framework of Generative Grammar and Minimalism. Regarding coordination, Coordination Phrase (CoP) is proposed as the category for conjunctive, disjunctive and adversative coordination, assuming that the conjuncts are specifiers and complements of CoP in a right-branching coordination structure. The specific derivation for each types of coordination is then applied.
As for gapping in conjunction, in LSC it shows similarities with VP-ellipsis, especially because it can appear also in subordination. Moreover, the availability of only distributed scope negation (¬A&¬B) and the presence of contrastive topic and contrastive focus require a large coordination structure, that is, CP coordination. In order to derive gapping, I propose movement of the arguments to TopP and FocP followed by the deletion of TP at PF, with [E] feature in the head of FocP.Aquesta tesi ofereix una descripció i una anàlisi sintàctica per a la coordinació i el “gapping” en coordinació conjuntiva en llengua de signes catalana (LSC), dins el marc generativista i minimista. Pel que fa a la coordinació, la categoria sintàctica que es proposa és “Coordination Phrase” (CoP) per a la coordinació conjuntiva, disjuntiva i adversativa. A l’estructura, ramificada a la dreta, els constituents de la conjunció són especificadors i complements de CoP. La derivació per a cada tipus de coordinació s’aplica a partir d’aquest model. Pel que fa al “gapping”, mostra proprietats similars a l’el·lipsi de SV (VP-ellipsis), sobretot perquè pot aparèixer en subordinació. A més, la l’existència només d’un abast distribuït de la negació (¬A&¬B) i la presència de tòpic i focus contrastius mostra la necessitat de tenir una coordinació “àmplia” on els dos conjunts siguin CPs. En la derivació de “gapping”, els arguments es mouen a TopP i FocP, seguits de l’eliminació del TP a PF, ambel tret [E] posicionat al nucli de FocP.
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Cañas, Peña Sara. "Polar interrogatives in Catalan Sign Language (LSC): a comprehensive grammatical analysis". Doctoral thesis, Universitat Pompeu Fabra, 2021. http://hdl.handle.net/10803/670760.
Pełny tekst źródłaStreszczenie:
This thesis provides a morphosyntactic description of polar questions and
a pragmatic analysis of biased questions in Catalan Sign Language (LSC).
Polar questions in LSC are obligatorily marked with a specific combination
of non-manual marking features and optionally marked with a question
particle. Given that, at least, the most prominent feature, eyebrow position,
does not remain constant, LSC displays different combinations of
non-manuals to mark this structure. Empirical evidence supports an analysis
in which each combination of non-manuals conveys a different bias
and a novel feature-based description system explains and predicts those.
Therefore, each combination of non-manuals, as well as the appearance of
the question particle, is shown to not only mark sentence type but also to
encode specific pragmatic meanings.Aquesta tesi ofereix una descripció morfosintàctica de les preguntes polars i una anàlisi pragmàtica de les preguntes esbiaixades en llengua de signes` catalana (LSC). Les preguntes polars en LSC es marquen obligatòriament amb una combinació específica de trets no manuals i, opcionalment, amb una partícula interrogativa. Ates que, si més no, el tret més destacat, la posició de les celles, no roman constant, l’LSC mostra diferents combinacions de no manuals per marcar aquesta estructura. L’evidencia científica dona suport a una anàlisi en què cadascuna de les combinacions de no manuals codifica un biaix diferent; un nou sistema de descripció basat en trets explica i prediu aquest comportament. Per tant, cada combinació de no manuals, així com l’aparició de la partícula interrogativa, es realitza no nomes per marcar el tipus d’oració, sinó també per codificar significats pragmàtics.
Esta tesis proporciona una descripción morfosintáctica de las preguntas polares y un analisis pragmático de las preguntas sesgadas en lengua de signos catalana (LSC). Las preguntas polares se marcan obligatoriamente con una combinacion específica de rasgos no manuales y opcionalmente con una partícula interrogativa. Dado que, al menos, el rasgo mas destacado, la posición de las cejas, no permanece constante, la LSC muestra diferentes combinaciones de no manuales para marcar esta estructura. La evidencia empírica sostiene un analisis en el que cada combinación de no manuales transmite un sesgo diferente; un novedoso sistema de descripcion basado en rasgos explica y predice esta conducta. Por ende, cada combinación de no manuales, así como la aparición de la partícula interrogativa, se realiza no solo para marcar el tipo de oración, sino también para codificar significados pragmáticos.
6
Navarrete-González, Alexandra. "Focus and contrast in Catalan Sign Language (LSC) : form and interpretation". Doctoral thesis, Universitat Pompeu Fabra, 2022. http://hdl.handle.net/10803/673320.
Pełny tekst źródłaStreszczenie:
This thesis provides a description and a pragmatic analysis of the expression and interpretation of focus and contrast in Catalan Sign Language (LSC). I argue that LSC data provides empirical evidence that contrast is an independent notion in Information Structure that can overlap with topics and foci, and that involves different types, which are built compositionally. All types of contrast share a basic meaning (semantic parallelism), which is essential for an element to be contrastive, and which is expressed through a specific combination of non-manual markers (NMMs). Additional prosodic NMMs are used to trigger more complex meanings, like exhaustivity or counterexpectation. Moreover, a first description of focus particles and clefts in LSC is provided, together with a pragmatic analysis of exhaustivity and non-truth conditional meaning (presuppositions and implicatures) in these constructions.Aquesta tesi proporciona una descripció i una anàlisi pragmàtica de l’expressió i la interpretació del focus i el contrast en llengua de signes catalana (LSC). Defenso que l’LSC aporta proves empíriques que el contrast és una noció independent en el camp de l’estructura informativa que se solapa amb el tòpic i els focus de l’oració i que es pot dividir en subtipus que es conformen de manera composicional. Tots els tipus de contrast comparteixen un significat bàsic (paral·lelisme semàntic), que és imprescindible perquè un element sigui contrastiu i que s’expressa a través d’una combinació específica de marcadors no manuals (MNM). MNM addicionals són emprats per expressar significats més complexos, com ara l’exhaustivitat i la contraexpectació. A més, s’ofereix una primera descripció de les partícules focals i les oracions clivellades en LSC, i una anàlisi pragmàtica de l’exhaustivitat i el significat no veritatiu-condicional (implicatures i pressuposicions) que es deriva d’aquestes construccions.
Esta tesis proporciona una descripción y un análisis pragmático sobre la expresión y la interpretación del foco y el contraste en lengua de signos catalana (LSC). Defiendo que la LSC aporta pruebas empíricas de que el contraste es una noción independiente en el campo de la estructura informativa que se solapa con el tópico y el foco de la oración y que se puede dividir en subtipos que se constituyen de manera composicional. Todos los tipos de contraste comparten un significado básico (paralelismo semántico), que es imprescindible para que un elemento sea contrastivo y que se expresa a través de una combinación específica de marcadores no manuales (MNM). MNM adicionales son utilizados para expresar significados más complejos, como la exhaustividad y la contraexpectación. Además, se presenta una primera descripción de las partículas focales y de las oraciones escindidas en LSC, así como un análisis pragmático de la exhaustividad y del significado no veritativo-condicional (implicaturas y presuposiciones) que se deriva de estas construcciones.
7
Veiga, Busto Raquel. "Person and number in Catalan Sign Language pronouns". Doctoral thesis, Universitat Pompeu Fabra, 2022. http://hdl.handle.net/10803/673364.
Pełny tekst źródłaStreszczenie:
Languages use different resources to specify the numerosity of the
referents and to denote the speech act participants. This thesis describes
the morphophonological strategies used in Catalan Sign Language
(LSC) personal pronouns to encode these distinctions. In a nutshell,
I argue that the expression of person and number is achieved by
using two interrelated strategies: person is expressed through spatial
features (locations in the signing space which are defined in relation
to the signer’s body), number is grammatically marked by the path
specifications of the sign (movements connecting spatial locations).
Combining these two operations results in the formal marking of three
person distinctions (with a further contrast between exclusive, minimal
inclusive and augmented inclusive in the first person) and four number
values (singular, dual, paucal and plural).Les llengües utilitzen diferents recursos per a expressar el nombre dels referents i designar als participants en els actes de parla. Aquesta tesi descriu les estratègies morfofonològiques utilitzades als pronoms personals de la llengua de signes catalana (LSC) per a codificar aquestes distincions. En resum, es proposa que les categories de persona i nombre s’expressen utilitzant dues estratègies interrelacionades: la persona s’expressa a través de trets espacials (localitzacions a l’espai sígnic definides en relació amb el cos del parlant), el nombre es marca gramaticalment a través d’especificacions en la trajectòria del signe (moviments que connecten localitzacions espacials). La combinació d’aquestes dues operacions es tradueix en la codificació formal de tres distincions de persona (amb una oposició addicional entre exclusivitat, inclusivitat mínima i inclusivitat augmentada en la primera persona) i quatre valors de nombre (singular, dual, paucal i plural).
Las lenguas utilizan diferentes recursos para expresar el número de los referentes y designar a los participantes en el acto de habla. Esta tesis describe las estrategias morfofonológicas usadas en los pronombres personales de la lengua de signos catalana (LSC) para codificar estas distinciones. En síntesis, se propone que las categorías de persona y número se expresan utilizando dos estrategias interrelacionadas: la persona se expresa a través de rasgos espaciales (localizaciones en el espacio sígnico definidas en relación con el cuerpo del hablante), el número se marca gramaticalmente a través de especificaciones en la trayectoria del signo (movimientos que conectan localizaciones espaciales). La combinación de estas dos operaciones se traduce en la codificación formal de tres distinciones de persona (con una oposición adicional entre exclusividad, inclusividad mínima e inclusividad aumentada en la primera persona) y cuatro valores de número (singular, dual, paucal y plural).
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Mesli, Samir. "Rôle du Lipolysis Stimulated Receptor (LSR) : expression chez la souris adulte et au cours de l'embryogénèse : conséquences de l'invalidation du gène LSR". Bordeaux 2, 2005. http://www.theses.fr/2005BOR21308.
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Le Lipolysis Stimulated Receptor (LSR) fixe les lipoprotéines contenant l'apolipoprotéine (apo) B et l'apoE en présence des acides gras, et son affinité est optimale pour les fractions lipoprotéiniques les plus riches en triglycérides. Dans notre étude, nous avons utilisé les techniques du Northern blot, de la PCR quantitative en temps réel et de l'immunofluorescence pour examiner l'expression du LSR chez la souris adulte et au cours du développement embryonnaire. Chez l'adulte l'ARNm LSR est retrouvé dans tous les tissus étudiés sauf dans le muscle et le coeur. Les ARNm sont abondants dans le foie, le poumon, l'intestin, le rein et dans certains tissus stéroidogéniques (ovaires et testicules). Ils sont également présents à tous les stades embryonnaires étudiés. Les résultats de l'expression protéique sont corrélés à ceux de l'expression transcriptionnelle. Ainsi, le "patron" d'expression du LSR chez la souris adulte apporte des arguments supplémentaires sur son rôle possible de ce récepteur dans le transport lipidique au niveau de ces organes. Afin d'étudier le rôle physiologique du LSR in vivo, nous avons tenté d'obtenir des souris LSR-/- par recombinaison homologue. Sur un total de 379 souris génotypées, trois homozygotes seulement ont été identifiées. Cette répartition montre une grande létalité des homozygotes. Celle-ci se produit entre 12,5 et 15,5 jours de gestation. Les embryons LSR-/- se distinguent par un foie de taille réduite. Ces résultats indiquent que le LSR est indispensable pour le développement embryonnaire. Par ailleurs, étant donné que les souris hétérozygotes ne présentent aucun phénotype particulier, nous avons voulu analyser l'impact de l'invalidation de l'un des deux allèles du LSR chez des souris totalement déficientes en un autre récepteur de lipoprotéines à apoB/E, le LDLR. Comparés aux souris LDL-/-, les doubles mutants [LSR+/- ; LDR-/-] appelés LDLSR ont des taux plasmatiques de cholestérol total significativement plus faibles par diminution du cholestérol contenu dans les lipoprotéines non LDL et HDL. Ce résultat pourrait être expliqué par l'intervention de mécanismes compensateurs comme l'augmentation de l'activité d'autres récepteurs de lipoprotéines. Grâce au modèle LDLSR, nous avons pu mettre en évidence pour la première fois un rôle in vivo du LSR dans la régulation du métabolisme du cholestérol et des lipoprotéinesThe lipolysis stimulated receptor (LSR) recognizes apolipoprotein B/E-containing lipoproteins in the presence of free fatty acids, and is thought to be involved in the clearance of triglyceride-rich lipoproteins (TRL). The distribution of LSR in mice was studied by Northern blots, quantitative PCR and immunofluorescence. In the adult, LSR mRNA was detectable in all tissues except muscle and heart, and was abundant in liver, lung, intestine, kidney, ovaries and testes. During embryogenesis, LSR mRNA was detectable at 7. 5 days post-coitum (E7) and increased up to E17 in parallel to prothrombin, a liver marker. In adult liver, immunofluorescence experiments showed a staining at the periphery of hepatocytes as well as in fetal liver at E12 and E15. These results are in agreement with the assumption that LSR is a plasma membrane receptor involved in the clearance of lipoproteins by liver, and suggest a possible role in steroidogenic organs, lung, intestine and kidney. To explore the role of LSR in vivo, the LSR gene was inactivated in 129/Ola ES cells by removing a gene segment containing exons 2-5, and 129/Ola-C57BL/6 mice bearing the deletion were produced. Although heterozygotes appeared normal, LSR homozygotes were not viable, with the exception of three males, while the total progeny of genotyped wild-type and heterozygote pups was 376. Mortzality of the homozygote embryos was observed between days 12. 5 and 15. 5 of gestation, a time at which their liver was much smaller than that of their littermates, indicating that the expression of LSR is critical for liver and embryonic devellopment. To evaluate the effect of inactivation of one allele LSR in LDL receptor-deficient mice, we produce double knockout animals [LSR+/-] called LDLSR Total plasma cholesterol concentration were approximately 40 % less as compared with LDLR-/- mice These finding supported the hypothesis of upregulation of other receptors in LDLSR mice
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Mosella, Sanz Marta. "Les construccions relatives en llengua de signes catalana (LSC)". Doctoral thesis, Universitat de Barcelona, 2012. http://hdl.handle.net/10803/123717.
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Aquesta tesi presenta la primera descripció de les construccions relatives (CR) restrictives en llengua de signes catalana (LSC). A més, inclou una proposta d’anàlisi en el marc de la gramàtica generativa transformacional informada tipològicament.
Respecte a la tipologia sintàctica de les CR, aportem proves que mostren que aquestes construccions, en LSC, són estructures circumnominals, és a dir, amb el pivot (o antecedent) dins de l’oració relativa (OR). Això contrasta amb les CR més comunes a les llengües indoeuropees, les adnominals, en què el pivot apareix fora de l’OR. Les CR circumnominals de la LSC, d’acord amb el que diu la tipologia, presenten un determinant que nominalitza l’estructura.
Les CR circumnominals de la LSC no apareixen mai a la seva posició bàsica dins de l’oració matriu sinó que han d’aparèixer o bé avantposades o bé posposades. Aquesta mateixa distribució s’observa a les CR circumnominals d’altres llengües de signes, com ara la llengua de signes italiana (LIS).
L’anàlisi que presentem és essencialment la d’elevació, en la línia de Kayne (1994), encara que hi introduïm algunes modificacions per tal de donar compte de les dades de la LSC. Aquesta anàlisi, en principi, seria d’aplicació a les CR circumnominals en general, es tracti de llengües orals o signades.
Aquest treball representa, doncs, una contribució tant a la tipologia com a la lingüística teòrica.This work contains the first description of Catalan Sign Language (LSC) Relative Clauses (RCs). Also, it proposes an analysis within the Generative framework that takes a typological approach. Regarding the syntactic typology of LSC RCs, they are circumnominal. In other words, they show the pivot (or antecedent) inside the RC. This contrasts with the most common RCs in Indo-European languages, the adnominal ones, in which the pivot appears outside the RC, that is, in the matrix clause. Other evidence that supports the idea that RCs in LSC are circumnominal is put forward. For instance, this structure shows a determiner that nominalizes the whole construction, as usually found in circumnominal RCs across languages. Circumnominal RCs in LSC never appear in its basic position inside the matrix clause. They have to appear or fronted or postposed to the matrix one. This same distribution is also found in other sign language RCs, for instance, in Italian Sign Language (LIS). The analysis presented here essentially follows the raising one (Kayne 1994). However, I have added some modifications in order to take into account crucial LSC data. The resulting analysis can be applied to the circumnominal construction as a whole, that is, in both oral and signed languages. To sum up, this work is a contribution to both typology and theoretical linguistics.
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Ribera, i. Llonc Eulàlia. "La categoria verb en la llengua de signes catalana (LSC)". Doctoral thesis, Universitat Autònoma de Barcelona, 2015. http://hdl.handle.net/10803/300741.
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Aquesta tesi se centra en la identificació i descripció de la categoria verb (V) en la llengua de signes catalana (LSC). Hem emmarcat la nostra recerca en el marc teòric de Borer (bàsicament 2005a i 2005b), el qual ens ha permès analitzar la LSC des d’una perspectiva diferent a d’altres treballs descriptius.
Al llarg d’aquest treball descrivim els functors lèxics (FL) i els functors funcionals (FF) que hem pogut identificar per a la categoria V en el corpus objecte del nostre estudi en LSC. Seguint diverses investigacions referides a altres llengües de signes, iniciem el nostre treball amb un estudi d’un conjunt de parells nom-verb de la LSC i n’identifiquem les diferències morfofonològiques. En aquest nivell de descripció morfofonològica distingim dos FL que fan que l’arrel lèxica inserida en el nucli del SV esdevingui i s’identifiqui com a equivalent a V, cosa que permet que se li assigni una estructura eventiva. Posteriorment, analitzem els FF (This thesis focuses on the identification and description of the category verb (V) in Catalan Sign Language (LSC). The research has been developed within the Borer’s theoretical framework (basically 2005a and 2005b), which has provided an approach to LSC different from the one typically found in previous descriptive studies. We describe the Lexical Functors (FL) and Functional Functors (FF) that we have identified for the category V in LSC in the corpus of our study. Following other investigations in sign languages, the present study starts with an analysis of a set of name-verb pairs in LSC, and we identify their morphophonological differences. At this level of morphophonological differences we distinguish two FL that assign an eventive structure to the root and identify it as V-equivalent. We also analyse the set of FF ( and independent f-morph) that may cause morphophonological changes in the verbalized root and contribute to identifying the category V. In this sense, the Functional Projections that are described in this thesis on the category V in LSC are: Agreement, Aspect, Manner and Quantity. Concerning Agreement, we analyse Person Agreement, Spatial Agreement and Number Agreement in LSC from a syntactic perspective. In contrast to most studies on Agreement in signed languages, we highlight the role of location as a part of the of the Person Agreement Functional Projection, even in roots classified as ‘plain roots’. We show that there is a hierarchical order that reflects Agreement with arguments and that depends on different syntactic structures. With respect to Aspect, we argue that ‘telicity’ and ‘atelicity’ are defined as Quantity, according to Borer (2005a,b), and that Aspect is built in syntax. Concerning the two FL identified for verbal roots, we show that one of them (FL1) assigns non-quantity eventive information to the verbalized root and the other (FL2#) a quantity one. We argue that this lexical eventive information is not crucial in syntax, first, because it can be modified, and, second, because verbalized roots can appear in different syntactic contexts, no matter which is its initial morphophonologycal information. Finally, in this study we show the need of a Manner Functional Projection and a Quantity Functional Projection (different from FL) to identify the category V in LSC. They both force a number of morphophonological changes in the V-equivalent roots and, consequently, they help to identify the category V. For each of them, we describe the relevant found in the corpus we have analysed, their different morphophonological realizations and the restrictions they may have.
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Fisher, Matthew J. "The search for low scale technicolor in the Z + γ channel in 7 TeV ATLAS data". The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1343620633.
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Pinault, Lucile. "Targeting Lsr2/DNA Complexation for Dysregulation of Gene Expression in Mycobacterium tuberculosis". University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1365087235.
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Côté, Jean-Philippe. "L'héritage religieux du discours de la League for Social Reconstruction, LSR". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ60708.pdf.
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Fujimoto, Shinji. "Beam commissioning and suppression of transverse coherent instability at S-LSR". 京都大学 (Kyoto University), 2007. http://hdl.handle.net/2433/136765.
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Lewis, Spenser M. "Simplified core physics and fuel cycle cost model for preliminary evaluation of LSCR fueling options". Thesis, Georgia Institute of Technology, 2014. http://hdl.handle.net/1853/51772.
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The Liquid Salt Cooled Reactor (LSCR) provides several potential benefits compared to pressurized water-cooled reactor systems. These include low operating pressure of the liquid salt coolant, the high burnup tolerance of the fuel, and the high operating temperatures which leads to increases in efficiency. However, due to inherently low heavy metal loading, the fuel cycle design presents specific challenges. In order to study options for optimizing the fuel design and fuel cycle, SCALE6.1 was used to create simplified models of the reactor and look at various parameters. The primary parameters of interest included packing factor and fuel enrichment. An economic analysis was performed on these results by developing a simple fuel cycle cost (FCC) model that could be used to compare the different options from an economic standpoint. The lithium enrichment of the FLiBe coolant was also investigated. The main focus was to understand the practical limitations associated with the Li-7 enrichment and whether it could be used for beneficial purposes. The main idea was to determine whether a lower-than-equilibrium enrichment could be used at reactor start up so that the Li-6 isotope acts as a burnable absorber. The results for the lithium enrichment study showed that the enrichment converges over time, but the amount of time required to reach steady state is much too long and the FLiBe coolant could not be utilized for reactivity control as a burnable absorber. The results found through this research provide reasonable guidelines for expected costs and narrow down the types of configurations that should be considered as fuel design options for the LSCR. Additionally, knowledge was gained on methods for modeling the system not only accurately but also efficiently to reduce the required computing power and time.
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Lee, Byeong-Seok. "Linear Switched Reluctance Machine Drives with Electromagnetic Levitation and Guidance Systems". Diss., Virginia Tech, 2000. http://hdl.handle.net/10919/29751.
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Many electrically propelled, and magnetically levitated and guided actuation systems (maglev) use either linear induction or synchronous machine topologies. From the cost, reliability, fault tolerance, and phase independence points of view, linear switched reluctance topologies are attractive for transportation application. This thesis investigates a novel topology in which a linear switched reluctance machine (LSRM) propulsion drive is incorporated in the magnetically levitated and guided vehicle. Designs of the LSRM and dc electromagnet, analytical aspects of modeling and dynamics of the vehicle, and closed loop control of propulsion, levitation, and guidance systems are discussed with comprehensive simulations and experimental results.
Due to the lack of standard design procedure for LSRM, a novel design procedure is proposed using the current knowledge and design procedure of rotating switched reluctance machines. Analysis procedures for the phase winding inductance, propulsion and normal forces with translator position are developed with a lumped-parameter magnetic circuit model and the results from it are verified with two-dimensional finite element analysis. Extensive experimental correlation of inductance, propulsion and normal forces to validate the analysis and design procedure is presented.
For the stable operation of the electromagnetic levitation and guidance systems, which have inherent unstable characteristics, the air gap position and force/current control loops are designed using PID (or PD) and PI controllers, respectively, and implemented and tested. The step-by-step design procedures for each controller are systematically derived. A feedforward compensation strategy for the levitation air gap control is proposed to reject the external force disturbance mainly caused by the normal force component generated in the LSRM propulsion drive system. The reduction of mechanical vibration and hence the enhancement of ride quality is achieved. Extensive dynamic simulations and experimental results for the integrated maglev system are presented with a 6 m long prototype system. Experimental correlation proves the validity of the controller design procedure based on the single-input and single-output model, and shows the feasibility of the LSRM-propelled electromagnetic levitation and guidance systems.
A novel maglev topology in which only two sets of LSRMs are utilized to control individually propulsion, levitation, and guidance forces is proposed. One set of the linear switched reluctance actuator produces the levitation and propulsion forces and the other set generates the propulsion and guidance forces. The proposed architecture, thereby, obviates the need for design, development, and implementation of separate actuation systems for individual control of propulsion, levitation, and guidance forces and in contrast to most of the present practice. Further, the proposed system utilizes each of the linear switched reluctance actuation system for producing the propulsion force, thereby giving an overall high force density package for the entire system. The feasibility of the proposed system by finite element analysis is demonstrated.Ph. D.
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El, Hajj Aseel. "Rôle du LSR dans la régulation de l’homéostasie du cholestérol dans le système nerveux central". Electronic Thesis or Diss., Université de Lorraine, 2019. http://www.theses.fr/2019LORR0317.
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Le cholestérol est un lipide crucial dans le système nerveux central (SNC) et sa régulation stricte assure un développement et une fonction neuronaux appropriés. Le cholestérol est synthétisé dans le SNC par les cellules gliales qui produisent et sécrètent le cholestérol pour répondre aux besoins neuronaux. Les lipoprotéines et leurs récepteurs sont des éléments clés de ce transport intercellulaire : où ces derniers reconnaissent, lient et endocytent les lipoprotéines contenant du cholestérol. Le récepteur de lipoprotéine stimulé par lipolyse (LSR) est le récepteur le plus récemment découvert dans le SNC. C'est un complexe protéique multimère qui subit des changements conformationnels lors de la liaison des acides gras libres, révélant ainsi un site de liaison qui reconnaît les apolipoprotéines B et E. L'inactivation complète du gène LSR est létale au niveau embryonnaire, probablement due à une fuite de la barrière hématoencéphalique. De plus, des études sur des souris LSR +/- ont révélé une modification de la distribution du cholestérol et des fonctions cognitives. Notre premier objectif était de réaliser le profilage LSR au niveau des tissus et des cellules. Nos résultats ont révélé une expression différentielle des sous-unités de LSR. Les études in vitro sur des cultures de cellules primaires ont démontré que le LSR était fortement exprimé dans différentes régions du SNC, à la fois dans les cellules gliales et neuronales. Notre hypothèse est qu'une forte expression du LSR dans les cellules gliales pourrait jouer un rôle dans le contrôle de la synthèse du cholestérol, en limitant le cholestérol en circulation dans le liquide extracellulaire du cerveau. Pour vérifier cette hypothèse, nous avons développé un système inductible Cre-lox ciblant spécifiquement les cellules gliales. Le phénotypage comportemental démontre un déficit de la fonction olfactive ayant un impact sur la mémoire sociale de ces animaux. Bien qu'aucun problème de vision n'ait été détecté, le test de reconnaissance d'objet a démontré que la mémoire visuelle était affectée. En outre, les tests sur le labyrinthe en Y et celui de Barns semblent affecter la mémoire à court et à long terme. Nos résultats suggèrent que l'inactivation spécifique de LSR dans les cellules gliales altère la mémoire des animaux, affectant la mémoire spatiale et sociale. Fait intéressant et similaire à AD, le signe précoce était lié au déficit en olfaction. En utilisant une stratégie combinant phénotypage comportemental, immunomarquage et analyse biochimique de marqueurs spécifiques de la plasticité synaptique, ce modèle pourrait également être utilisé pour déterminer le rôle du LSR dans la cognition cérébrale et le trafic de cholestérol dans le SNC, et pourrait fournir les moyens de valider le LSR en tant que cible thérapeutique potentielle pour le traitement des dommages causés par le stockage des lipides et le développement de maladies neurodégénératives dans le cerveau vieillissantCholesterol is a crucial lipid in the central nervous system (CNS) and its strict regulation ensures proper neuronal development and function. Cholesterol is synthesized in the CNS by glial cells which produce and secrete cholesterol to meet neuronal needs. Lipoproteins and their receptors are key elements of this intercellular transport: where the latter recognize, bind and endocytose lipoproteins containing cholesterol. The lipolysis stimulated lipoprotein receptor (LSR) is the most recently discovered receptor in the CNS. It is a multimeric protein complex that undergoes conformational changes during the binding of free fatty acids, thus revealing a binding site which recognizes apolipoproteins B and E. Complete inactivation of the LSR gene is lethal at embryonic level, probably due to a leaky blood brain barrier. In addition, studies in LSR +/- mice have revealed a change in the distribution of cholesterol and cognitive functions. Our first goal was to perform LSR profiling at the tissue and cell level. Our results revealed a differential expression of the LSR subunits. In vitro studies in primary cell cultures have shown that LSR is highly expressed in different regions of the CNS, both in glial and neuronal cells. Our hypothesis was that a strong expression of LSR in glial cells could play a role in controlling the synthesis of cholesterol, by limiting the cholesterol circulating in the extracellular fluid of the brain. To verify this hypothesis, we have developed an inducible Cre-lox system specifically targeting glial cells. Behavioral phenotyping demonstrated a deficit in olfactory function which has an impact on the social memory of these animals. Although no visual problems were detected, the object recognition test showed that the visual memory was affected. Additionally, Y and Barnes mazes tests revealed an impacted short- and long-term memory. Our results suggest that specific inactivation of LSR in glial cells impairs animal memory, affecting spatial and social memory. Interestingly and similarly to AD, the early signs monitored olfactory deficits. Using a strategy combining behavioral phenotyping, immunostaining and biochemical analysis of specific markers of synaptic plasticity, this model could also be used to determine the role of LSR in brain cognition and cholesterol trafficking in the CNS, and could provide the means to validate LSR as a potential therapeutic target for the treatment of damage caused by lipid storage and the development of neurodegenerative diseases in the aging brain
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Kertmen, Aykut. "Evaluation of the lLttoral Combat Ship (LSC) potential for the Turkish Navy". Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2006. http://library.nps.navy.mil/uhtbin/hyperion/06Sep%5FKertmen.pdf.
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Thesis (M.S. in Systems Engineering)--Naval Postgraduate School, September 2006.Thesis Advisor(s): Edward Fisher. "September 2006." Includes bibliographical references (p. 83-88). Also available in print.
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Seehara, Panpailin. "Mixed-conducting LSC/CGO and Ag/CGO composites for passive seperation membranes". Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.517682.
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Dense ceramic oxygen separation membranes can pass oxygen perm-selectively at elevated temperature and have potential for improving the performance and reducing the cost of several industrial processes: such as the conversion of natural gas to syngas, or to separate oxygen from air for oxy-fuel combustion in electricity generation (to reduce NOx emissions and facilitate CO2 sequestration). These pressure-driven solid state membranes are based on fast oxygen-ion conducting ceramics, but also need a compensating flow of electrons. Dual-phase composites are attractive since they provide an extra degree of freedom, compared with single phase membranes, for optimising the overall membrane performance. In this study, composites containing gadolinia doped ceria (CGO, Ce0.9Gd0.1O2- ) and either strontium-doped lanthanum cobaltite (LSC, La0.9Sr0.1CoO3- or La0.6Sr0.4CoO3- ) or silver (Ag) were investigated for possible application as oxygen separation membranes in oxy-fuel combustion system. These should combine the high oxygen ion conductivity of CGO with the high electronic conductivity and fast oxygen surface exchange of LSC or silver. Dense mixed-conducting composite materials of LSC/CGO (prepared by powder mixing and sintering) and Ag/CGO composites (prepared by silver plus copper oxide infiltration method) showed high relative density (above 95%), low background gas leakage and also good electrical conduction. The percolation threshold of the electronic conducting component was determined to be approximately 20 vol.% for both LSC compositions and 14 vol.% for Ag. Isotopic exchange and depth profiling by secondary ion mass spectrometry was used to investigated the oxygen tracer diffusion (D*) and surface exchange coefficient (k*) of the composites. Composites just above the electronic percolation threshold exhibited high solid state oxygen diffusivity, fast surface exchange activity moderate thermal expansion and sufficient mechanical strength thus combining the benefits of their constituent materials. The preliminary work on oxygen permeation measurement showed that the reasonable magnitude of oxygen fluxes is possible to be achieved. This indicates that the composites of LSC/CGO and Ag/CGO are promising for further development as passive oxygen separation membranes.
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Shirai, Toshiyuki. "One-dimensional beam ordering of protons at ion storage ring, S-LSR". 京都大学 (Kyoto University), 2007. http://hdl.handle.net/2433/59310.
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Kertmen, Aykut. "Evaluation of the Littoral Combat Ship (LSC) potential for the Turkish Navy". Thesis, Monterey California. Naval Postgraduate School, 2006. http://hdl.handle.net/10945/2625.
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This thesis will examine the potential of the two competing designs for the Littoral Combat Ship (LCS), with regard to potential deployment of this vessel type by the Turkish Navy. The first design is by Lockheed Martin and has been designated the USS Freedom as the U.S. Navyâ s first LCS. The second design is by General Dynamics. This thesis will focus on the LCS usage concepts in Naval Capability Pillars and Information Operations. As a transformation platform, the LCS will be critical in implementing new operational concepts and in providing a focused, littoral mission platform for joint forces. Its superior speed and maneuverability; low radar, infrared, and acoustic signatures; and ability to lay distributed sensor fields are all fundamental to mission success. It will also carry a â squadronâ of unmanned vehicles (air, surface, and undersea) that will considerably extend its sensor and weapon coverage and provide substantial Anti-Submarine Warfare (ASW) capabilities. This thesis will also discuss present and future platforms and their concepts of operation in Turkish littoral waters (Aegean Sea, Black Sea, and Mediterranean Sea).
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Denis-Lagache, Nicolas. "Commutation ou extinction de l'expression du BCR et impact sur la cellule B". Thesis, Limoges, 2015. http://www.theses.fr/2015LIMO0071/document.
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Lors de la reconnaissance de leur antigène spécifique, les lymphocytes B vont s’activer et interagir avec les autres cellules des organes lymphoïdes secondaires (cellules folliculaires dendritiques, lymphocytes T, …) pour former un centre germinatif où le locus IgH va être remanié afin d’accroitre l’affinité des immunoglobulines pour l’antigène (grâce à l’hypermutation somatique des régions variables (SHM) et de décliner l’activité effectrice des anticorps selon plusieurs types de fonction grâce à la commutation de classe des régions constantes ou « switch u CSR», afin d’éliminer selon diverses stratégies l’antigène . Ces deux mécanismes sont initiés par l’Activation Induced Deaminase (AID) qui cible l’ADN au niveau des cytosines pour les changer en uracile, aboutissant à des cassures simple brin ou double brin lorsque que les mésappariements sont proches les uns des autres.Il a été montré qu’AID est capable de cibler la région régulatrice en 3’ du locus IgH au niveau de régions LS, action qui aboutit à la délétion complète des gènes C du locus, à la perte de l’expression du BCR et à la mort cellulaire lors de la recombinaison suicide du locus (LSR). Dans notre étude, nous avons réalisé un modèle knock-in du gène Cμ humain en aval de la dernière région LS dans le but de sauver les cellules B réalisant la LSR sur les dernières régions LS par l’expression d’un BCR humanisé (modèle LSR-μKI). Notre modèle indique que l’insertion du gène Cμ humain en aval de l’élément hs4 de la 3’RRpermet en effet de remplacer certaines recombinaisons LSR par un switch vers l’expression d’IgM humanisée », et module en outre qualitativement certains aspects de la réponse immunitaire humorale. Notre modèle « rapporteur » de la LSR suggère aussi que l’évènement de LSR est un phénomène régulé qui augmente avec l’activation B. L’étude ex vivo de cellules B issues du modèle suggère que la LSR est possible lors d’une réponse T indépendante comme T dépendante. Elle se montre aussi inductible par les ligands TLR4 mais non TLR9. L’étude du répertoire des IgM humaines indique une utilisation biaisée des familles de VH, avec notamment sur utilisation de la famille VH5murine, suggérant donc que l’incidence de la LSR varie avec la structure des régions variables du BCR et pourrait donc être dépendante de l’affinité contre des antigènes/ligands qui restent à caractériserAfter antigen recognition, B cells are activated and interact with other cells within secondarylymphoid organs (dendritic cells, T lymphocytes …) to form a germinal center. In the GC, the IgH locusis reorganized in order to increase the affinity of immunoglobulins for antigen through somatichypermutation (SHM) of V(D)J regions and to configure them into several forms harboring diversifiedmodes of action after “class switc recombination” (CSR). Both mechanisms are initiated by ActivationInduced Deaminase (AID) which targets DNA cytosines to convert them into uracil, then causing singleor double strand breaks in DNA when the mismatchs are located close to each other. It has been shownthat AID can target the IgH locus 3’ regulatory region on specific regions called LS, then leading to thetotal deletion of IgH locus C genes, loss of BCR expression and cell death by locus suicide recombination(LSR). In our study, we created a human Cμ knock-in model distal to the hs4 element of the 3’RR, in anattempt to rescue cells after the LSR event. Our model showed that this insertion indeed succeededinto replacing LSR by “class switching to humanized IgM” and also qualitatively modulated someaspects of the humoral response. This new LSR reporter model additionally supports the hypothesisthat LSR is regulated and increases with B cell activation. Studies of ex vivo B cells from the modelsuggest that LSR can occur in T dependent and independent manners, but is induced by triggering TLR4but not TLR9. Studies of the human IgM repertoire showed a biased use of VH families, and notably themouse VH5 family was used more frequently than in the control group. The BCR repertoire bias stronglysuggests that LSR is at least in part a matter of affinity of the BCR variable regions for antigens andligands that remain to be characterized
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Danielsson, Johan, i Gustav Gistvik. "Estimation, model selection and evaluation of regression functions in a Least-squares Monte-Carlo framework". Thesis, Linköpings universitet, Produktionsekonomi, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-110927.
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This master thesis will investigate one solution to the problem issues with nested stochastic simulation arising when the future value of a portfolio need to be calculated. The solution investigated is the Least-squares Monte-Carlo method, where regression is used to obtain a proxy function for the given portfolio value. We will further investigate how to generate an optimal regression function that minimizes the number of terms in the regression function and reduces the risk of overtting the regression.
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Hagström, Adrian, i Rustam Stanikzai. "Writer identification using semi-supervised GAN and LSR method on offline block characters". Thesis, Högskolan i Halmstad, Akademin för informationsteknologi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-43316.
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Block characters are often used when filling out forms, for example when writing ones personal number. The question of whether or not there is recoverable, biometric (identity related) information within individual digits of hand written personal numbers is then relevant. This thesis investigates the question by using both handcrafted features and extracting features via Deep learning (DL) models, and successively limiting the amount of available training samples. Some recent works using DL have presented semi-supervised methods using Generative adveserial network (GAN) generated data together with a modified Label smoothing regularization (LSR) function. Using this training method might improve performance on a baseline fully supervised model when doing authentication. This work additionally proposes a novel modified LSR function named Bootstrap label smooting regularizer (BLSR) designed to mitigate some of the problems of previous methods, and is compared to the others. The DL feature extraction is done by training a ResNet50 model to recognize writers of a personal numbers and then extracting the feature vector from the second to last layer of the network.Results show a clear indication of recoverable identity related information within the hand written (personal number) digits in boxes. Our results indicate an authentication performance, expressed in Equal error rate (EER), of around 25% with handcrafted features. The same performance measured in EER was between 20-30% when using the features extracted from the DL model. The DL methods, while showing potential for greater performance than the handcrafted, seem to suffer from fluctuation (noisiness) of results, making conclusions on their use in practice hard to draw. Additionally when using 1-2 training samples the handcrafted features easily beat the DL methods.When using the LSR variant semi-supervised methods there is no noticeable performance boost and BLSR gets the second best results among the alternatives.
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Seeharaj, Panpailin. "Mixed-conducting LSC/CGO and Ag/CGO composites for passive oxygen separation membranes". Thesis, Imperial College London, 2010. http://hdl.handle.net/10044/1/5724.
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Dense ceramic oxygen separation membranes can pass oxygen perm-selectively at elevated temperature and have potential for improving the performance and reducing the cost of several industrial processes: such as the conversion of natural gas to syngas, or to separate oxygen from air for oxy-fuel combustion in electricity generation (to reduce NOx emissions and facilitate CO2 sequestration). These pressure-driven solid state membranes are based on fast oxygen-ion conducting ceramics, but also need a compensating flow of electrons. Dual-phase composites are attractive since they provide an extra degree of freedom, compared with single phase membranes, for optimising the overall membrane performance. In this study, composites containing gadolinia doped ceria (CGO, Ce0.9Gd0.1O2- ) and either strontium-doped lanthanum cobaltite (LSC, La0.9Sr0.1CoO3- or La0.6Sr0.4CoO3- ) or silver (Ag) were investigated for possible application as oxygen separation membranes in oxy-fuel combustion system. These should combine the high oxygen ion conductivity of CGO with the high electronic conductivity and fast oxygen surface exchange of LSC or silver. Dense mixed-conducting composite materials of LSC/CGO (prepared by powder mixing and sintering) and Ag/CGO composites (prepared by silver plus copper oxide infiltration method) showed high relative density (above 95%), low background gas leakage and also good electrical conduction. The percolation threshold of the electronic conducting component was determined to be approximately 20 vol.% for both LSC compositions and 14 vol.% for Ag. Isotopic exchange and depth profiling by secondary ion mass spectrometry was used to investigated the oxygen tracer diffusion (D*) and surface exchange coefficient (k*) of the composites. Composites just above the electronic percolation threshold exhibited high solid state oxygen diffusivity, fast surface exchange activity moderate thermal expansion and sufficient mechanical strength thus combining the benefits of their constituent materials. The preliminary work on oxygen permeation measurement showed that the reasonable magnitude of oxygen fluxes is possible to be achieved. This indicates that the composites of LSC/CGO and Ag/CGO are promising for further development as passive oxygen separation membranes.
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Masuda, Sayuri. "Angulin/LSR defines cell corners for tricellular tight junction formation in epithelial cells". Kyoto University, 2011. http://hdl.handle.net/2433/142056.
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Reilly, Liam. "LSRP : defence styles, alexithymia, illness perceptions, and HRQOL in IBD ; Systematic lit : neurodegenerative diseases and third wave therapies". Thesis, Queen's University Belfast, 2018. https://pure.qub.ac.uk/portal/en/theses/lsrp-defence-styles-alexithymia-illness-perceptions-and-hrqol-in-ibd-systematic-lit-neurodegenerative-diseases-and-third-wave-therapies(15fb8a2d-8e69-4740-a18e-095c495b9cae).html.
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The effectiveness of third wave therapies on neurodegenerative diseases. Objectives: Previous research has identified the effectiveness of third wave therapies in reducing the symptoms of a variety of physical and psychological presentations. This systematic review will assess the efficacy of third wave therapies for adults with neurodegenerative diseases. Methods: The selected electronic databases, Medline, PsychInfo, Embase and Cinahl, were used to search for studies that were published from the inception of each database to January 2018. Third wave therapies (e.g. Acceptance and Commitment Therapy, Dialectical Behaviour Therapy, Mindfulness-Based Cognitive Therapy) and neurodegenerative diseases (e.g. Alzheimer disease, Parkinson’s disease, Prion disease) were included as search terms. Results: The systematic literature search revealed 570 potentially relevant papers. From this number, seven studies were found to be eligible for inclusion in the narrative synthesis. These studies reported on four neurodegenerative diseases and five adapted third wave therapy interventions. There were found to be mixed results on the effectiveness of third wave therapies for improving both physical and psychological symptoms in a variety of neurodegenerative diseases. Conclusions: At this stage, it is not possible to deem whether third wave therapies are feasible in offering psychological or physical benefits to the neurodegenerative disease population. However, despite not being able to draw any firm conclusions, the use of third wave therapies has shown some potential benefits. Further randomised controlled trials to assess the effectiveness of adapted third wave therapies are required. Practitioner Points: + Three studies identified improvements in cognitive functioning in the intervention group in comparison with the control group. + Some studies also found improvements in anxiety, depression, quality of life, and mindfulness following third wave therapy interventions. - However, an increase in depression, stress and a reduction in quality of life found following third wave therapies. - As this is the first review of this population and third wave therapies, it has not been possible to focus more closely on just one specific third wave therapy or neurodegenerative disease. Further research on the effectiveness of third wave therapies in this population is required. LSRP: Defence styles, alexithymia, illness perceptions, and HRQOL in IBD. Background/aims: The role of psychological factors in the development and progression of Inflammatory Bowel Disease (IBD) is not completely understood. Several studies have suggested that defence styles, alexithymia and illness perceptions each individually influence the way a person experiences their disease, thereby impacting on health related quality of life (HRQoL). The study aimed to expand the knowledge base and assist in offering a better understanding of these variables. Methods: The study employed a survey design and used opportunity sampling to recruit participants with IBD from a Regional Crohn’s and Colitis support group and outpatient Gastroenterology clinics. Participants were given questionnaire packs containing measures and were asked to post them back to the researcher. One hundred and thirty-nine participants were included in the study, of these 73.5% were female and 26.5% were males. 53.6% of participants reported being diagnosed with Crohn’s disease, where as 41.3% were diagnosed with Ulcerative Colitis, 1.4% were diagnosed with both, and 3.6% had a diagnosis of IBD but did not have a clear diagnosis of either Crohn’s or Colitis. The majority of participants identified that they were diagnosed with IBD between the ages of 20 and 29. Most participants (60.4%) felt that stress and worry was the cause of their IBD. Results: The study found that defence styles, alexithymia and illness perceptions were all correlated with HRQoL. However, multiple regression analysis revealed that the alexithymia subtest, “difficulty identifying feelings” and the neurotic defence style were the only variables that had a significant relationship with HRQoL. It was also found that females and people that were recently diagnosed also had a worse HRQoL. Conclusion: These findings suggest that females who are recently diagnosed with IBD and have difficulty identifying feelings as well as a reliance on neurotic defence styles have a worse HRQoL. Therefore, screening of this population and the introduction of psychotherapy to assist with emotional care might be beneficial in improving HRQoL. Practitioner Points: + Gender, time since diagnosis, neurotic defence styles and difficulties identifying own emotional experiences found to potentially contribute to poorer HRQoL. + Therefore, therapy using emotional identification, especially when a person is just diagnosed, might be beneficial to people with IBD. - The study used a cross sectional design, therefore it is not possible to infer causation. Future research should use a prospective design.
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Hu, Jiancheng. "Regulation of Lsc activity and role in B cell migration and antigen receptor signaling /". Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007.
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Thesis (Ph.D. in Immunology) -- University of Colorado Denver, 2007.Typescript. Includes bibliographical references (leaves 103-118). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
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Pinçon, Anthony. "Implication du récepteur LSR (lipolysis stimulated lipoprotein receptor) dans le contrôle de l’homéostasie du cholestérol cérébral et les capacités cognitives au cours du vieillissement". Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0141/document.
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La maladie d'Alzheimer (MA) est une maladie neurodégénérative touchant plusieurs millions de personnes. La MA a une origine multifactorielle. Diverses études suggèrent qu'une perturbation du métabolisme du cholestérol contribue au développement de la MA. Cependant, la littérature présente beaucoup de confusion. Il est donc crucial de mieux caractériser le métabolisme et l'implication du cholestérol dans la MA. Ce travail s'est intéressé au récepteur Lipolysis Stimulated Lipoprotein Receptor (LSR) qui est un récepteur hépatique aux lipoprotéines participant à la clairance des lipides en phase post prandiale. Les objectifs de cette thèse ont été de caractériser la présence du récepteur LSR dans le cerveau de souris, de déterminer son rôle dans le contrôle de l'homéostasie du cholestérol cérébral et dans la physiopathologie de la MA. Ainsi, nous avons caractérisé la présence de LSR dans des structures cérébrales importantes pour les capacités cognitives et le métabolisme énergétique. Grâce à un modèle de souris hétérozygote pour le récepteur LSR, nous avons mis en évidence que la délétion d'un allèle LSR entraine une altération du métabolisme du cholestérol cérébral au cours du vieillissement, qui est corrélée avec une augmentation de la sensibilité au stress amyloïde. Ces résultats suggèrent un rôle du récepteur LSR dans le contrôle de l'homéostasie du cholestérol cérébral et renforcent l'idée qu'une altération de cette dernière peut impacter la physiopathologie de la MA. Enfin, nous avons observé que la déficience d'un allèle LSR chez des souris placées sous un régime hyperlipidique pouvait impacter le métabolisme lipidique périphérique ainsi que l'anxiété de ces sourisAlzheimer's disease (AD) is a neurodegenerative disease affecting millions of people. The origin of AD is multifactorial. Studies suggest that disturbance of cholesterol metabolism contributes to AD development. However, data in the literature is conflicting. It is therefore crucial to better characterize the metabolism and involvement of cholesterol in AD. This work focused on the Lipolysis Stimulated Lipoprotein Receptor (LSR), a hepatic lipoprotein receptor involved in the clearance of lipoproteins during the postprandial phase. The objectives of this thesis were to characterize LSR receptor expression profile in the mouse brain, and to determine its role in both brain cholesterol homeostasis and in the pathophysiology of AD. We identified and characterized LSR expression in brain structures that are involved in cognitive abilities and the regulation of energy metabolism. Next, using a mouse model heterozygous for the LSR receptor, we were able to demonstrate that the deletion of one allele LSR causes impaired brain cholesterol metabolism in aging, which was correlated with increased susceptibility to amyloid stress. These results suggest a role of LSR receptor in brain cholesterol homeostasis and show that alterations of the brain cholesterol metabolism can impact AD pathophysiology. Finally, we observed that the deficiency of an LSR allele in mice on a high fat diets affected peripheral lipid metabolism and the anxiety in these mice
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Dalloul, Iman. "Switch Canonique en Cis ou Trans et Recombinaisons Suicides du Locus IgH". Thesis, Limoges, 2018. http://www.theses.fr/2018LIMO0049.
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L'activation des cellules B est connue pour s’accompagner de remodelages des gènes d’immunoglobulines qui permettent la maturation d'affinité des régions variables d'Ig par hypermutation somatique SHM et la commutation de classe CSR. Ces deux processus sont sous le contrôle de la région régulatrice 3’ (3’RR) du locus IgH. Pendant la CSR, le locus IgH subit des changements tridimensionnels mettant les régions switch ciblés par AID à proximité de la région 3’RR afin de faciliter la recombinaison. La sous-unité MED1 du complexe Médiateur favorise cette interaction à longue distance avec la 3’RR mais elle intervient aussi dans la transcription germinale qui précède la CSR afin de faciliter l’activité d’AID. Comme récemment démontré chez la souris, la région 3’RR peut aussi être ciblée par des recombinaison médiée par AID, mais contrairement à la CSR, ce type de recombinaison qui joint la région Sμ et la 3’RR et qui s’appelle recombinaison suicide du locus IgH ou LSR entraîne une délétion complète de l’ensemble des gènes constants conduisant à la mort des cellules B par la perte de l’expression du BCR. Nous montrons maintenant que la LSR médiée par AID se produit aussi dans les cellules B humaines activées avec les deux régions 3’RR (3’RR1 en aval de Cα1 et 3’RR2 en aval de Cα2) et qui peut toucher l’allèle fonctionnel mais elle peut aussi être biallélique marqué par une quasi-absence de ce type de recombinaison dans les plasmocytes de la moelle mais aussi dans les cellules B mémoires quiescents du sang et qui peut par contre être réinduite à haut niveau lorsque les cellules B mémoires sont réactivées. Toutes nos conditions de stimulation utilisées in-vitro induit la LSR, sans permettre de discerner comment se fait « le choix » entre la CSR et la LSR. Nos résultats montrent par contre que la sous-unité MED1 semble influencer la transcription de la 3’RR et la recombinaison LSR chez la souris. L’inactivation conditionnelle de MED1 influence l’accessibilité transcriptionnelle et donc les recombinaisons sans affecter les marques épigénétiques du locus IgH. Cette étude de MED1 a aussi révélé que l’ensemble des processus stimulés par l’IgH 3’RR sont « Médiateur-dépendants » (SHM, CSR sans distinction de la cis et la trans-CSR, expression augmentée du locus dans les plasmocytes…), comme semble l’être également le processus de choix des segments variables au cours des réarrangements VHDJHB-cell activation is accompanied by remodeling of immunoglobulin genes resulting in affinity maturation of Ig variable regions by somatic hypermutation (SHM) and class switch recombination (CSR). These two processes are under the control of the 3' regulatory region (3’RR) of the IgH locus. During CSR, the IgH locus undergoes three dimensional changes bringing the AID-targeted switch regions near the 3'RR region to facilitate recombination. The MED1 subunit of the Mediator complex promotes this long-distance interaction with the 3'RR, but it is also implicated in germinal transcription preceding CSR in order to facilitate AID activity. As recently demonstrated in mice, the 3'RR region can also be targeted by AID-mediated recombination, but unlike CSR, this type of recombination joining the Sμ region and 3'RR (called Locus Suicide Recombination or LSR) results in a complete deletion of all the constant genes leading to B-cell death by loss of B Cell Receptor expression. We now show that AID-mediated LSR also occurs in activated human B cells with the two 3'RR (3'RR1downstream of Cα1 and 3'RR2 downstream of Cα2) and affects the functional allele. It can also be bi-allelic marked by the absence of this type of recombination in plasma cells of the bone marrow but also in quiescent blood memory B cells. LSR occurs at high level when the memory B cells are reactivated. All in-vitro stimulations induce LSR, without identifying conditions favoring either CSR and the LSR. Our results also show that the MED1 subunit appears to influence 3’ RR transcription and LSR in mice. Conditional inactivation of MED1 influences transcriptional accessibility and therefore recombination without affecting epigenetic markers of the IgH locus. This study also revealed that all the processes controlled by the 3'RR are "mediator -dependent" (SHM, CSR without distinction between Cis and Trans -CSR, increased expression of the IgH locus in the plasma cells ...), as well as the choice of varia ble segments during VDJH rearrangements
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Xie, Ting. "Interactions épistatiques et modifications épigénétiques pour la stratification moléculaire des maladies chroniques". Thesis, Université de Lorraine, 2017. http://www.theses.fr/2017LORR0339/document.
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Les maladies chroniques, comme les maladies cardiovasculaires (MCV), la maladie d'Alzheimer (AD), la dépression et l'ostéoporose, sont les principales causes de mortalité dans le monde. L'identification de facteurs de risque communs à ces maladies pourrait contribuer à un vieillissement «sain» mieux surveillé en utilisant des stratégies personnalisées de prédiction des risques, de prévention précoce et de traitement adéquat, en tenant compte des comorbidités très souvent existantes. Dans cette thèse, 8 publications ont été développées. Dans un premier temps, j'ai résumé, dans un article de revue, les défis actuels et les opportunités de la pharmacogénomique des médicaments contre les maladies cardiovasculaires. J'ai participé à la formation d'un consortium international, le Consortium VEGF et j'ai participé à une étude qui a identifié des interactions épistasiques entre les polymorphismes qui régulent les niveaux de VEGF et la pression artérielle et les indices d'adiposité. J'ai également démontré qu’un marqueur génétique de VEGF, le rs4416670, était significativement associé à un risque accru de dépression. En outre, j'ai signalé deux interactions significatives entre les variantes liées au VEGF affectant la densité minérale osseuse du col fémoral chez les femmes ménopausées. J'ai également étudié deux marqueurs liés au métabolisme des lipides : l'apolipoprotéine E (APOE) et le «lipolysis-stimulated receptor» (LSR). J'ai trouvé que le variant LSR rs916147 peut interagir avec APOE d'une manière qui inverse l'effet protecteur de l'allèle ε2 de l'APOE sur les lipides sanguins, fournissant ainsi de nouvelles connaissances sur les mécanismes de l'hyperlipoprotéinémie de type III. Les interactions épistasiques entre ces deux gènes augmentent également le risque d’AD même en l'absence de l'allèle à risque, APOE ε4. Finalement, j'ai réalisé des études épigénetiques (EWAS) sur l'obésité centrale et les traits lipidiques chez des individus sains. Les résultats suggèrent qu'un CpG pourrait affecter le tour de taille à travers une voie de signalisation de l'insuline. En outre, deux CpGs ont été associées aux niveaux des triglycérides par des gènes liés aux maladies cardiaques génétiques (PRKAG2) et à l'inhibition de la signalisation Wnt / bêta-caténine impliquée dans le développement des MCV et d’AD (KREMEN2). En conclusion, dans cette thèse j’ai utilisé l'étude de l'épistasie et de l'épigénétique pour identifier des interrelations complexes entre VEGF, LSR, APOE et différentes maladies chroniques (MCV, AD, ostéoporose, dépression) proposant ainsi de nouveaux mécanismes et des dénominateurs communs de ces maladies qui devraient être utilisés comme biomarqueurs de médecine personnaliséeChronic diseases, like cardiovascular diseases (CVD), Alzheimer’s disease (AD), depression and osteoporosis, are major causes of mortality in the world. Identification of common to those diseases risk factors could help for a better-monitored ‘healthy’ aging, by promotion of personalised strategies for risk prediction, early prevention and adequate treatment, all taking into account the very often existing comorbidities. In this thesis, 8 publications have been developed. Initially, in a review paper, I have summarised the current challenges and opportunities of pharmacogenomics of CVD medications. I have participated in the formation of an international consortium, the VEGF Consortium, and I have participated in a study that identified significant epistatic interactions between polymorphisms that regulate the levels of VEGF and their effects on blood pressure and adiposity indexes. I have also demonstrated that one genetic marker of VEGF, rs4416670, was significantly associated with an increased risk for depression. Furthermore, I have reported two significant interactions between VEGF-related variants affecting the femoral neck bone mineral density in post-menopausal women. I have focused also on two markers linked with lipids metabolism: the apolipoprotein E (APOE) and the lipolysis-stimulated receptor (LSR). I have found that the LSR variant rs916147 can interact with APOE in a way that reverses the protective effect of the ε2 allele of APOE on blood lipids, thus providing new insights in the mechanisms underlying type III hyperlipoproteinemia. Epistatic interactions between these two genes have also been shown to increase the risk of AD, even in the absence of the known risk allele APOE ε4. Finally, I have performed epigenome-wide association studies (EWAS) on central obesity and blood lipid traits in healthy individuals. The results suggest that one methylation probe could affect waist circumference through an insulin-signaling pathway. Furthermore, two methylations probes were associated with triglycerides levels through genes linked with genetic heart diseases (PRKAG2) and with inhibition of the Wnt/beta-catenin signaling that is involved in CVD and AD development (KREMEN2). In conclusion, this thesis used the study of epistasis and epigenetics and identified complex inter-relationships between VEGF, LSR, APOE and different chronic diseases (CVD, AD, osteoporosis, depression) and novel mechanisms that link disease development with DNA methylation, thus demonstrating their role as common denominators of diseases that can be used as valuable markers in personalised medicine
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Han, Cheng-Yu. "Clock Synchronization and Localization for Wireless Sensor Network". Thesis, Université Paris-Saclay (ComUE), 2018. http://www.theses.fr/2018SACLS453/document.
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Les réseaux de capteurs sans fil (WSN) jouent un rôle important dans des applications telles que la surveillance de l'environnement, le suivi de sources et le suivi médical, ...etc. Dans les WSN, les capteurs ont la capacité d'effectuer l'échantillonnage des données, des calculs distribués et de fusionner des données. Pour effectuer ces tâches complexes, la synchronisation des horloges et la localisation sont fondamentales et essentielles. Les WSN ont été largement étudiés ces dernières années et la littérature scientifique rapporte de nombreux résultats qui les rendent applicables pour de nombreuses applications. Pour d'autres, la recherche doit encore trouver des solutions à certains des défis posés par la limitation énergétique, la dynamicité et la faible puissance de calcul. Dans le but de contribuer à la recherche sur les WSN, cette thèse propose de nouveaux algorithmes pour la synchronisation d'horloge et la localisation. La synchronisation d'horloge est nécessaire afin que les effectuent de manière efficace la fusion de données. En appliquant l'algorithme de synchronisation d'horloge, les capteurs établissent un consensus temporel et travaillent donc au même rythme. Compte tenu de la dynamicité, des faibles capacités de calcul et de la parcimonie des WSN, un nouvel algorithme de synchronisation décentralisée à impulsions couplées est proposé pour améliorer la précision de la synchronisation. L'avantage de ce type d'algorithme est que les capteurs échangent des impulsions au lieu de paquets, de sorte que non seulement la communication est efficace, mais aussi robuste à toute défaillance des capteurs dans le réseau. La localisation de capteurs a été largement étudiée dans la littérature scientifique. Cependant, la qualité et la précision de la localisation peuvent encore être améliore. Cette thèse applique l'algorithme LSCR (Régression de régions corrélées à signes dominants) au problème de localisation. Avec LSCR, on évalue des régions de confiance avec des niveaux de confiance prescrits, qui fournissent non seulement on emplacement mais aussi la confiance en cet emplacement. Dans cette thèse, plusieurs approches de localisation sont implémentées et comparées. Le résultat de la simulation montre que, sous hypothèses modérées, LSCR obtient des résultats compétitifs par rapport à d'autres méthodesWireless sensor networks (WSNs) play an important role in applications such as environmental monitoring, source tracking, and health care,... In WSN, sensors have the ability to perform data sampling, distributed computing and information fusion. To perform such complex tasks, clock synchronization and localization are two fundamental and essential algorithms. WSNs have been widely studied in the past years, and the scientific literature reports many outcomes that make them applicable for some applications. For some others, research still needs to find solutions to some of the challenges posed by battery limitation, dynamicity, and low computing clock rate. With the aim of contributing to the research on WSN, this thesis proposes new algorithms for both clock synchronization and localization. For clock synchronization, sensors converge their local physical clock to perform data fusion. By applying the clock synchronization algorithm, sensors converge the time difference and therefore work at the same rate. In view of dynamicity, low computing and sparsity of WSN, a new pulse-coupled decentralized synchronization algorithm is proposed to improve the precision of the synchronization. The benefit of this kind of algorithm is that sensors only exchange zero-bit pulse instead of packets, so not only the communication is efficient but also robust to any failure of the sensors in the network. Localization of sensors has been widely studied. However, the quality and the accuracy of the localization still have a large room to improve. This thesis apply Leave-out Sign-dominant Correlated Regions (LSCR) algorithm to localization problem. With LSCR, one evaluates the accurate estimates of confidence regions with prescribed confidence levels, which provide not only the location but also the confidence of the estimation. In this thesis, several localization approaches are implemented and compared. The simulation result shows under mild assumptions, LSCR obtains competitive results compared to other methods
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Barberà, Altimira Gemma. "The meaning of space in Catalan Sign Language (LSC). Reference, specificity and structure in signed discourse". Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/81074.
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This thesis concerns the use of sign space in Catalan Sign Language (LSC) at the discourse level. I argue that non-descriptive locations are established in the three spatial planes and I describe the grammatical features contained within them. Spatial locations are morphophonologically marked with an abstract point in space which does not have a specific direction and which is categorically interpreted in the linguistic system. In LSC, the frontal plane is grammatically relevant for specificity marking: lower spatial locations correlate with specificity, whereas upper locations correlate with non-specificity. Moreover, the incorporation of discourse structure into the analysis shows that the establishment of lower spatial locations also denotes discourse prominence. Hence, spatial locations are integrated into the grammar of LSC and they are analysed here with respect to the role they play in the denotation of specificity and discourse structure. The analysis is framed under the formalisation of Discourse Representation Theory, on the basis of a small-scale LSC corpus.Aquesta tesi se centra en l’ús de l’espai en llengua de signes catalana (LSC) a nivell discursiu. Defenso que les localitzacions no descriptives s’estableixen en els tres plans espacials i en descric els trets gramaticals. Les localitzacions espacials es representen morfofonològicament amb un punt abstracte a l’espai que no té una direcció específica en els plans espacials i que s’interpreta categòricament en el sistema lingüístic. En LSC, el pla frontal és gramaticalment important i denota especificitat: les localitzacions baixes correlacionen amb especificitat, mentre que les localitzacions altes correlacionen amb no especificitat. A més, la incorporació de l’estructura del discurs a l’anàlisi demostra que les localitzacions espacials baixes també denoten prominència discursiva. Les localitzacions espacials són, per tant, part de la gramàtica de la LSC i aquí les analitzo en relació al rol que tenen en l’expressió de l’especificitat i l’estructura discursiva. L’anàlisi s’emmarca en la formalització de la Discourse Representation Theory, tot basant-se en les dades d’un corpus en LSC a petita escala.
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Hornuß, Daniel [Verfasser], i Klaus [Akademischer Betreuer] Aktories. "Untersuchungen zur Wechselwirkung zwischen dem C. difficile-Toxin CDT und seinem zugehörigen Zellrezeptor LSR an Plasmamembranen". Freiburg : Universität, 2014. http://d-nb.info/1123478481/34.
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Wiechert, Johanna [Verfasser], Julia [Akademischer Betreuer] Frunzke i Matias [Gutachter] Zurbriggen. "Silencing and counter-silencing of the Lsr2-like protein CgpS in Corynebacterium glutamicum / Johanna Wiechert ; Gutachter: Matias Zurbriggen ; Betreuer: Julia Frunzke". Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1229191712/34.
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Rajendran, Kaliaperumal. "The development and application of an analytical method for the determination of technetium-99 in the aquatic environment". Thesis, University of Glasgow, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.321830.
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Xiaoyu, Dang, Zhang Yong i Zhou Tingxian. "A METHOD TO ENHANCE THE BIT RATE OF LINEAR CODE GENERATOR IN SPREAD-SPECTRUM COMMUNICATION SYSTEM". International Foundation for Telemetering, 1999. http://hdl.handle.net/10150/607337.
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International Telemetering Conference Proceedings / October 25-28, 1999 / Riviera Hotel and Convention Center, Las Vegas, NevadaBecause of the limits of feedback devices, high-speed pseudo-noise code generators cannot depend simply on the improvement of clock rate. Based on the characteristic equation of linear feedback registers and the m-sequence sampling theory as well, deduction is made to indicate a novel way to improve the speed of pseudo-noise code generators 2^l (2^l < n, n is the length of registers) times as fast as the conventional one. Also, we extend our applications to non-reducible and non-primitive polynomials. It could be a good way to generate these linear codes at higher rates.
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Kadir, Joanne, i Petra Forsberg. "Logistik och distribution ur ett hållbarhetsperspektiv : I vilken utsträckning läkemedelsföretag har LSR som en del i sitt övergripande hållbarhetsarbete". Thesis, Uppsala universitet, Företagsekonomiska institutionen, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-417815.
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Studien syftar till att öka kunskapsutvecklingen om hur företag arbetar med Logistik SocialResponsibility (LSR) genom att studera hållbarhets- och årsrapporter. Studien är avgränsad motläkemedelsbranschen och ämnar därför att undersöka i vilken utsträckning läkemedelsföretagenhar LSR som en del i sitt övergripande hållbarhetsarbete. Utformningen följer metodiken kvalitativriktad innehållsanalys. De utvalda studieobjekten är följande fem läkemedelsföretag: Johnson &Johnson, Roche, GlaxoSmithKline, Eli Lilly och AstraZeneca. Med en modifierad LSR-modellanalyserades utfallet med hjälp av fyra utvalda faktorer. Samtliga är kopplade till LSR:shuvudområden miljö, ekonomi och samhälle. Resultatet av den insamlade datan ska ge en plattformför kunskap- och erfarenhetsutbyte inom men även branscher emellan. Slutsatsen konkluderas tillatt samtliga läkemedelsföretag har omfattande hållbarhetsrapporter, dock på annat fokus än LSR,vilket kan tolkas till avsaknad av alternativ inom logistik och därmed även motivation då det inteleder till något värdeskapande.
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Kiška, Martin. "Technologie MultiProtocol Label Switching v sítích Ethernet". Master's thesis, Vysoké učení technické v Brně. Fakulta elektrotechniky a komunikačních technologií, 2014. http://www.nusl.cz/ntk/nusl-220653.
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In the introduction of this thesis the reasons for transition from older to a new technology called MultiProtocol Label Switching are mentioned – the modern technology enables simple network extension. The theoretical part contains basic principles of this techno- logy and their practical application for supplying private networks to the customers using provider’s network. In practical part packets are analyzed considering the theory. In addi- tion. All the technologies tested on a real network. Experience gained while working on this thesis are assessed during creating laboratory task for class Architecture of Networks intended for students of Bachelor’s study programme.
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Alsharairi, Naser Abdel Hamid Abdel Rahman. "Psychosocial Determinants of Food Choices among Australian Children: An Analysis of the Longitudinal Study of Australian Chiildren Database". Thesis, Griffith University, 2013. http://hdl.handle.net/10072/365441.
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There is significant impetus to identify the determinants of food choices and to develop effective ways to provide food guidance to children to enhance their health. Previous research has demonstrated the likely importance of personal determinants and the home food environment as targets to influence the food choices of children. The purpose of the present study was to analyse cross-sectional and longitudinal data to provide further insight into factors in childhood which affect children’s food choices.
The present research analyses involved data gathered from the national database of Growing up in Australia: The Longitudinal Study of Australian Children (LSAC). The LSAC design explored the developmental outcomes of children from early until late childhood, using a representative sample of 10,000 Australian children and their families, divided in two cohorts. The B-cohort (infant cohort) comprises data collected from 2004 (wave 1 data collection, 0-1 year at age of recruitment) until 2008 (wave 3 data collection, 4-5 year at age of recruitment). The K-cohort (child cohort) comprises data collected from 2004 (wave 1 data collection, 4-5 year at age of recruitment) until 2008 (wave 3 data collection, 8-9 year at age of recruitment). The data were collected from multiple sources such as mothers and fathers, teachers and carers, and direct assessments and observations. Data were primarily collected to provide information regarding a child’s personality and behaviour, family and relationship history, health and lifestyle, parenting practice, source of support, activities with children, education, paid work and physical measurements.Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Public Health
Griffith Health
Full Text
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Chan, Gordon. "The role of Vav-1, Vav-2 and Lsc in NK T-cell development and NK cell cytotoxicity". Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=966206258.
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Hanse, Marine. "Rôle du récepteur aux lipoprotéines, LSR, dans la régulation du transport et de la distribution des lipides alimentaires". Thesis, Vandoeuvre-les-Nancy, INPL, 2011. http://www.theses.fr/2011INPL086N/document.
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Le récepteur hépatique aux lipoprotéines LSR est impliqué dans la clairance des lipoprotéines riches en triglycérides telles que les résidus de chylomicrons pendant la phase postprandiale. La réduction de l’expression du LSR chez la souris (LSR+/-) est associée à une dyslipidémie et une lipémie postprandiale élevée. Afin de mieux comprendre la régulation de la distribution des lipides alimentaires, nous avons cherché quels étaient les facteurs pouvant affecter le niveau protéique de LSR. La leptine, hormone sécrétée par le tissu adipeux et connue pour son action d’hormone de satiété au niveau du système nerveux central, a été démontrée dans cette thèse comme modulant l’expression de LSR par la régulation de la transcription du gène lsr. La leptine est impliquée dans la régulation de la lipogénèse à travers SREBP-1. Grâce à l’utilisation d’un extrait de Garcinia cambogia contenant un inhibiteur de l’ATP citrate lyase, nous avons démontré une interaction importante entre les enzymes lipogéniques, l’expression de LSR et d’autres récepteurs lipoprotéiques, afin de maintenir un équilibre entre la synthèse de lipides endogènes et l’apport alimentaire de lipides exogènes. Soumises à un régime hyperlipidique, les souris sauvages montrent une diminution de l’expression des enzymes lipogéniques hépatiques, aggravée chez les souris LSR+/-. Ces résultats indiquent qu’il existe un mécanisme de maintien de l’équilibre entre la lipogénèse (synthèse endogène de lipides), la lipolyse (utilisation lipidique comme substrat énergétique) et le stockage de lipides à travers une forte interaction entre les enzymes lipogéniques et LSRThe hepatic lipoprotein receptor LSR is involved in the clearance of triglyceride-rich lipoproteins including chylomicrons remnants during the post-prandial phase. Reduced LSR protein expression in mice (LSR+/-) is associated with dyslipidemia and increased postprandial lipemia; these mice exhibit increased weight gain with aging or when placed under a high-fat diet. In order to better understand the regulation of the distribution of dietary lipids, we looked for factors that could regulate LSR protein levels. Leptin is a hormone secreted by the adipose tissue that is a centrally-acting satiety factor, and was demonstrated to modulate LSR mRNA and protein expression through the modulation of transcription of the gene lsr. Leptin has been reported be involved in the control of lipogenesis through SREBP-1c. Using Garcinia cambogia extract containing an inhibitor of ATP citrate lyase, we demonstrated that there is an important link between lipogenic enzymes and LSR protein levels and with other lipoprotein receptors that provides the means to maintain a balance between endogenous lipid synthesis and dietary intake of exogenous lipids. When exogenous lipid intake is increased in the form of a high-fat diet, mice exhibited a decrease in hepatic lipogenic enzymes expression, but a deficiency of LSR led to increased lipid content in the peripheral tissues. These results suggest the presence of mechanisms for the maintenance for the balance between lipogenesis (de novo endogenous lipid synthesis), lipolysis (lipids used as energy substrate), and lipid storage through an important link between lipogenic enzymes and LSR
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Mesquita, Fernanda Cristina de. "Efeito da liraglutida sobre a fibrose hep?tica e c?lulas estreladas ativadas". Pontif?cia Universidade Cat?lica do Rio Grande do Sul, 2017. http://tede2.pucrs.br/tede2/handle/tede/7593.
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Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES
Liver fibrosis is the wound healing response to repeated injury of the liver. This process begins with the damage of the parenchymal cells and subsequent inflammation, characterized by the rupture of the hepatic architecture associated to the increase of the expression of the components of the extracellular matrix. The development of hepatic fibrosis is based on the activation of hepatic stellate cells (HSC) that undergo phenotypic changes and are characterized by loss of vitamin A deposition and increased cell proliferation, triggering hepatic microcirculatory dysfunction and fibrogenesis in patients with chronic liver disease (CLD). Liraglutide is a GLP-1 agonist (glucagon-like peptide 1) well established as an antidiabetic drug, but also has anti-inflammatory properties, in addition to the effectiveness for NAFLD (non-alcoholic fatty liver disease). Therefore, the aim of this study was to evaluate the effects of liraglutide on the HSC phenotype and liver microvascular function using diverse pre-clinical models of CLD. The results obtained demonstrate that Liraglutide de-activated human and rat HSC phenotype through a GLP1-Rindependent mechanism. Liraglutide did not affect the HSC viability but decreased cell proliferation. CLD-rats receiving liraglutide exhibited significantly lower portal pressure (-20%) with a consequent reduction in intrahepatic vascular resistance. There was also a marked improvements in hepatic vascular function, fibrosis, HSC phenotype and sinusoidal endothelial phenotype. The anti-fibrotic effects of liraglutide were confirmed in human liver tissue. In conclusion, this study demonstrates for the first time that liraglutide improves hepatic sinusoidal endothelium in clinically relevant experimental models of cirrhosis, which leads to improvement in fibrosis and portal hypertension, and therefore is valid in the treatment of advanced chronic liver disease.
A fibrose hep?tica ? a resposta cicatricial do f?gado ? les?es repetidas. Este processo inicia com o dano das c?lulas parenquimatosas e consecutiva inflama??o, caracterizado pelo rompimento da arquitetura hep?tica associada ao aumento da express?o dos componentes da matriz extracelular. O desenvolvimento da fibrose hep?tica ? baseado na ativa??o das c?lulas hep?ticas estreladas (HSC) que sofrem mudan?as fenot?picas e se caracterizam pela perda do dep?sito de vitamina A e aumento da prolifera??o celular, desencadeando disfun??o microcirculat?ria hep?tica e fibrog?nese nos pacientes com doen?a hep?tica cr?nica (CLD). A liraglutida ? um an?lago do GLP-1 (glucagon-like peptide 1) bem estabelecido como f?rmaco antidiab?tico, mas que tamb?m possui propriedades antinflamat?rias, al?m da efetividade para NAFLD (doen?a hep?tica gordurosa n?o alco?lica). Por essa raz?o, o objetivo deste estudo foi avaliar os efeitos da liraglutida sobre o fen?tipo das HSC e a fun??o microvascular hep?tica utilizando diversos modelos pr?-cl?nicos de CLD. Os resultados obtidos demonstram que a liraglutida desativou o fen?tipo das HSC humanas e de ratos atrav?s de um mecanismo independente do receptor GLP1. A liraglutida n?o afetou a viabilidade das HSC mas diminuiu a prolifera??o celular. Os ratos com CLD que receberam liraglutida apresentaram press?o portal significativamente menor (-20%) com consequente redu??o da resist?ncia vascular intra-hep?tica. Houve tamb?m uma acentuada melhoria na fun??o vascular hep?tica, fibrose, fen?tipo das HSC e fen?tipo endotelial sinusoidal. Os efeitos anti-fibr?ticos da liraglutida tamb?m foram confirmados em tecido hep?tico humano. Como conclus?o, este estudo demonstra pela primeira vez que a liraglutida melhora o endotelio sinusoidal hep?tico em modelos experimentais clinicamente relevantes de cirrose, o que leva a melhora no quadro fibr?tico e na hipertens?o portal e, portanto, pode ser v?lido no tratamento da doen?a hep?tica cr?nica avan?ada.
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Williams, Kate Elizabeth. "Self-regulation from birth to age seven : associations with maternal mental health, parenting, and social, emotional and behavioural outcomes for children". Thesis, Queensland University of Technology, 2014. https://eprints.qut.edu.au/71568/1/Kate_Williams_Thesis.pdf.
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Self-regulation refers to our individual capacities to regulate our behaviours, emotions, and thoughts, with these skills developing rapidly across early childhood. This thesis examined sleep, emotional, and cognitive regulation development, and related parental influences, for children participating in the Longitudinal Study of Australian Children. Important longitudinal associations among children's self-regulation, maternal mental health, parenting, and later behaviour problems for children were also investigated. A unique contribution of this research was a prevalence estimate of early childhood self-regulation problems in Australian children that was documented for the first time.
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Hayes, Nicole. "Continuity and change in family engagement in home learning activities across the early years". Thesis, Queensland University of Technology, 2015. https://eprints.qut.edu.au/84653/1/Nicole_Hayes_Thesis.pdf.
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This research utilised data from The Longitudinal Study of Australian Children and explored continuity and change in parental engagement in home learning activities with young children. The findings indicated a decrease over time in parental engagement with children, from age to 2-3 years to 6-7 years. Rate of decrease impacted negatively on learning outcomes for language and literacy, and mathematical thinking, in the early years of school, when children were aged 6-7 years. Shared reading with children and interactions around everyday home activities and play, in which children and parents participate together, impact on children's later development.
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Sutanto, Taufik Edy. "Scalable fine-grained document clustering via ranking". Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/107459/1/Taufik%20Edy_Sutanto_Thesis.pdf.
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Dealing with big data, this thesis presents a novel and effective approach of scalable document clustering via ranking. The proposed clustering methods address the high-dimensionality problem in clustering analysis by introducing effective and computationally efficient cluster representations. The clustering via ranking approach is applicable to semi-supervised and unsupervised clustering problems. The proposed methods are applicable to static data as well as streaming data. The methods have been successfully tested with big social media data providing interesting insight.
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Harkous, Ali. "Analyse du comportement thermo-rhéo-cinétique et de l’adhésion des silicones liquides". Nantes, 2015. http://archive.bu.univ-nantes.fr/pollux/show.action?id=de408d5c-1177-445f-bdc1-27f99ba483c1.
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Le silicone liquide (LSR) est un élastomère bi-composant réticulable à chaud, dont la formulation peut être ajustée selon le domaine d’application. La formulation auto-adhérente permet le surmoulage du LSR sur des pièces plastiques par des méthodes d’injection bi-matières. Dans la présente étude, nous analysons ce procédé de surmoulage dans des conditions de mise en oeuvre industrielles en vue de déterminer les facteurs influents sur la qualité de l’adhésion. Dans un premier temps, la caractérisation thermo-rhéo-cinétique du LSR nous permet de comprendre le comportement thermique et rhéologique de la matière, et de calculer le modèle cinétique décrivant la réticulation. Le modèle, ainsi que les paramètres mesurés, sont utilisés dans la conception d’un moule qui sert à la réalisation des essais de surmoulage du LSR sur des pièces en thermoplastique dans des conditions contrôlées. Pour cela, le moule est instrumenté et régulé thermiquement pour simuler et reproduire les conditions de mise en oeuvre industrielles. Une instrumentation permettant la détection in-situ de la réticulation du LSR, avec modulation du signal, est également intégrée dans le moule. Les facteurs influents sur le procédé de surmoulage sont ensuite étudiés et présentés dans un plan d’expérience. Les pièces surmoulées sont caractérisées en cisaillement en mesurant des critères liés à l’adhésion, dont la force de rupture et la déformation. L’analyse des résultats permettra de déterminer l’influence de chaque facteur sur la qualité de l’adhésion et de calculer des modèles décrivant le phénomèneThe Liquid Silicone Rubber (LSR) is a two-component elastomer that crosslinks at high temperature, its formulation can be adjusted depending on the application domain. The self-adhesive formulation of LSR allows its overmolding onto plastic parts through bi-material injection methods. In this study, the LSR-plastic overmolding is analyzed in industrial implementation conditions in order to identify the key factors influencing the adhesion quality. Initially, thermo-rheo-kinetic characterization of LSR allows us to understand the thermal and rheological behavior, and calculate the kinetic model that describes the material crosslinking process. The model and the measured parameters are used in the design of a mold dedicated for performing the LSR-plastic overmolding tests under controlled conditions. As such, the mold is instrumented and thermally controlled to simulate and reproduce the industrial implementation conditions. Thermocouples instrumentation is also integrated into the mold for in-situ detection of the LSR crosslinking reaction. It uses the modulation of signal method. Then, influential factors on the overmolding process are studied and presented in an experimental design. The overmolded parts are characterized by shear test to measure the adhesion criteria, including the breaking stress and the shear strain. The analysis of the results determines the influence of each factor on the quality of adhesion and computes the models that describe the phenomenon
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Sandin, Måns. "Least Squares Monte Carlo-metoden & korgoptioner : En kvantitativ studie". Thesis, Umeå universitet, Institutionen för matematik och matematisk statistik, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-159925.
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Inom bank och försäkringsbranschen finns behov av framtidsprognoser och riskmått kopplade till finansiella instrument. För att skapa prisfördelningar, som kan användas som grund till olika riskmått, används ibland nästlad simulering. För att göra detta simuleras först en stor mängd yttre scenarion för någon tillgång, som används i ett finanisellt instrument. Vilket görs genom att priser simuleras över en tidsperiod. Detta utgör tidshorisonten varvid prisfördelningen befinner sig. Utifrån varje yttre scenario simuleras sedan ett antal inre. Som i sin tur används för att prissätta finansiella instrumentet i det yttre scenariot. En metod som används för att prisätta de yttre scenariona är Monte Carlo-metoden, vilket kräver ett stort antal inre scenarion för att prissättningen ska bli korrekt. Detta gör metoden krävande i tidsåtgång och datorkraft. Least Squares Monte Carlo-metoden är en alternativ metod som använder sig av regression och minstakvadratmetoden för att utföra prissättningen med ett mindre antal inre scenarion. En regressionsfunktion anpassas efter yttre scenarionas värden och används sedan för att omvärdera dessa, vilket minskar felen som ett mindre antal slumptal annars skulle ge. Regressionsfunktionen kan även användas för att prissätta värden utanför de som den anpassas efter, vilket gör att den kan återanvändas vid liknande beräkningar. I detta arbete undersöks hur väl Least Squares Monte Carlo-metoden beskriver prisfördelningen för korgoptioner, som är optioner med flera underliggande tillgångar. Tester utförs med olika värden för parametrarna och vikt läggs vid vilken effekt yttre scenarionas längd har, samt hur väl priserna beskrivs i prisfördelningens svansar. Resultatet är delvis svåranalyserat på grund av många extrema värden, men visade på svårigheter med prissättningen vid längre yttre scenarion. Vilket kan bero på att regressionsfunktionen som användes hade svårt att anpassa sig efter och beskriva mer spridda prisfördelningar. Metoden fungerade också sämre i den nedre delen av prisfördelningen, något som den dock delar med Standard Monte Carlo. Mer forskning behövs för att undersöka vilken effekt andra uppsättningar regressionsfunktioner skulle ha på metoden.In the banking and insurance industry, there exists a need for forecasting and measures of risk connecting to financial instruments. To create price distributions, used to create measures of risk, nested simulations are sometimes used. This is done by simulating a large amount of outer scenarios, for some asset in a financial instrument. Which is done by simulating prices over a certain time period. This now outlines the time horizon of the price distribution. From each outer scenario, some inner scenarios are simulated. Which in turn are used to price the financial instrument in the outer scenario. A common method for pricing the outer scenarios is the Monte Carlo method, which uses a large amount of random numbers for the pricing to be accurate. This makes the method time consuming, as well as requiring large amounts of computing power. The Least Squares Monte Carlo method is an alternative method, using regression and the least squares method to perform the pricing using a smaller amount of inner scenarios. A regression function is fitted to the values of the outer scenarios and then used to revalue these, reducing the error which a smaller number of random numbers otherwise would give. The regression function can also be used to price outside of the values used for the fitting, making it reusable in similar computations. This paper examines how well the Least Squares Monte Carlo-method describes the price distribution of basket options, which are options containing several underlying assets. Tests are made for different values for the parameters used and an emphasis is laid on the effect of the time length of the outer scenarios, also, how accurate the tails of the distribution are. The results are somewhat hard to analyze,due to some extreme values, but showed difficulties for the method, when pricing longer outer scenarios. This can be due to the regression function having problems fitting to - and valuing - broader price distributions. The method also performed worse in the lower parts of the distribution, something it shares with the standard Monte Carlo method. More research is needed to ascertain the effects of other regression functions.
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Dalbom, Axel, i Tim Svensson. "Implementing the Load Slice Core on a RISC-V based microarchitecture". Thesis, Uppsala universitet, Datorarkitektur och datorkommunikation, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-424385.
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As cores have become better at exposing Instruction-Level Parallelism (ILP), they have become bigger, more complex, and consumes more power. These cores are approaching the Power- and Memory-wall quickly. A new microarchitecture proposed by Carlson et. al claims to solve these problems. They claim that the new microarchitecture, the Load Slice Core, is able to outperform both In-Order and Out-of-Order designs in an area and power restricted environment. Based on Carlson et. al.’s work, we have implemented and evaluated a prototype version of their Load Slice Core using the In-Order Core Ariane. We evaluated the Load Slice Core by comparing the LSC to an IOC when running a microbenchmark designed by us, and when running a set of Application Benchmarks. The results from the Microbenchmark are promising, the LSC outperformed the comparable IOC in each test but problems related to the configuration of the design were found. The results from the Application Benchmarks are inconclusive. Due to time constraints, only a partially functioning LSC were compared to a comparable IOC. From these results we found that the LSC performed comparably or slightly worse than its IOC counterpart. More research on the subject is required for any conclusive statement on the microarchitecture can be made, but it is the opinion of this paper’s authors that it does show promise.
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Siengchum, Tritti. "Electrochemical Oxidation of Methane on Ni-Doped Perovskite Anode Solid Oxide Fuel Cell". University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1248205545.
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