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Tian, Yinghua. "Liver and partial liver transplantation : new models and mechanisms of partial liver graft regeneration /". Zürich, 2005. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253387.
Pełny tekst źródłaTector, A. Joseph. "Discordant liver xenotransplantation in recipients with liver failure". Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=84439.
Pełny tekst źródłaLiver xenotransplantation will be initially offered to patients with severe liver failure as a bridge to a human liver transplantation. The hypothesis tested in this thesis is that hyperacute rejection of liver xenografts placed into recipients with liver failure will be diminished because of the complement deficiency that accompanies liver failure. The experiments described in this thesis detail the development of an in vitro pig-to-human liver xenotransplant model incubating cultured pig hepatic endothelial cells (PHEC) and human serum in culture. We showed that either classical or alternative complement pathways could initiate endothelial injury. Next we developed the dog-to-pig liver xenograft model and characterized the lethal coagulopathy that results from hyperacute rejection. The coagulopathy results from the lack of function of platelets as well as their disappearance from the circulation. We then used the galactosamine induced liver injury model in porcine recipients of canine liver xenografts to demonstrate that hyperacute rejection in the setting of liver failure is diminished. We showed that; tissue injury, coagulopathy and platelet defect, and endothelial injury were diminished. Our experiments suggested that the cause of the decreased injury was the lack of complement in the pigs with galactosamine induced liver injury since the XNA levels were no different than in control animals. Our final experiments evaluated serum from patients with liver failure and compared the injury caused by incubation with PHEC. Serum from the liver failure patients had similar levels of XNA when compared with normal subjects, but had less complement activity, and less C3 and C4. Incubation of liver failure serum with PHEC caused much less injury and complement activation than serum from control subjects. The results in this thesis suggest that liver failure will have a significant impact on liver xenograft rejection, helping to diminish hyperacut
He, Qing. "Liver regeneration in rats after liver resection and small for size liver transplantation from living donors". [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=972086595.
Pełny tekst źródłaLindfelt, Jan O. W. "Hepatic nerves in hemostasis and glucose metabolism :". Lund : Dept. of Surgery, Lund University, 1993. http://catalog.hathitrust.org/api/volumes/oclc/39654187.html.
Pełny tekst źródłaHart, Nils Arnaud 't. "Improving liver preservation new strategies in liver procurement and preservation /". [S.l. : Groningen : s.n. ; University Library Groningen] [Host], 2007. http://irs.ub.rug.nl/ppn/30406856X.
Pełny tekst źródłaBikhchandani, Jai. "Extracorporeal liver perfusion as liver support device : a pilot study". Thesis, University of Leicester, 2012. http://hdl.handle.net/2381/11038.
Pełny tekst źródłaTriantafyllou, Evangelos. "Mechanisms of immune-mediated liver injury in acute liver failure". Thesis, King's College London (University of London), 2017. https://kclpure.kcl.ac.uk/portal/en/theses/mechanisms-of-immunemediated-liver-injury-in-acute-liver-failure(e3e4fdce-9d38-4bdf-b1b4-979f35aef0ae).html.
Pełny tekst źródłaFoss, Aksel. "Liver regeneration and partial liver transplantation an experimental study in the rat /". Lund : Dept. of Surgery, Lund University, 1992. http://books.google.com/books?id=d_BqAAAAMAAJ.
Pełny tekst źródłaLi, Jiangning. "Functional genomics and liver regeneration : transcriptional regulation on rapid liver regeneration /". Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/6351.
Pełny tekst źródłaKung, Janet Wui Cheung. "Investigating the liver progenitor cell niche in the developing human liver". Thesis, University of Edinburgh, 2016. http://hdl.handle.net/1842/25953.
Pełny tekst źródłaChan, See-ching. "Donor perspective of right lobe adult-to-adult live donor liver transplantation". Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B34736414.
Pełny tekst źródłaChan, See-ching, i 陳詩正. "Donor perspective of right lobe adult-to-adult live donor liver transplantation". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B34736414.
Pełny tekst źródłaMathur, Sachin. "Studies of prognosis and nutritional intervention in liver cirrhosis and liver transplantation". Thesis, University of Auckland, 2010. http://hdl.handle.net/2292/6892.
Pełny tekst źródłaPoli, G. "Biochemical studies on CC14̲-induced liver injury using isolated rat liver cells". Thesis, Brunel University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379250.
Pełny tekst źródłaUrdzik, Jozef. "Colorectal Cancer Liver Metastases : Effects of Chemotherapy on Liver Parenchyma and Resections". Doctoral thesis, Uppsala universitet, Institutionen för kirurgiska vetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-233790.
Pełny tekst źródłaSpanos, Christos. "Quantitative liver proteomics for biomarker discovery in non-alcoholic fatty liver disease". Thesis, University of Surrey, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.616323.
Pełny tekst źródłaGuthrie, Joy D. "Assessing Doppler-Derived Pressure Gradients and Liver Echogenicity to Predict Liver Disease". ScholarWorks, 2011. https://scholarworks.waldenu.edu/dissertations/969.
Pełny tekst źródłaLopez, Alexandre. "Liver preservation : New markers of viability for normal and steatotic liver grafts". Thesis, Université Paris-Saclay (ComUE), 2019. http://www.theses.fr/2019SACLS067.
Pełny tekst źródła"Marginal" livers are used to respond to the shortage of organs and the increase in the number of patients on the waiting list. The challenge is to successfully reduce the post-operative complications associated with these grafts by improving the quality of organ preservation. Assessing the quality of a liver to predict its function recovery is often performed while the organ is still in the donor. However, although the ischemia period directly affects the quality of the liver, the consequences of that period for the liver are rarely considered. No markers exist to evaluate those consequences, beyond a system of perfusion.Glycocalyx, a polysaccharidic layer at the surface of endothelial cells, has already proven its potential as a biomarker to evaliate the quality of livers. In steatotic rat livers, ischemia-repefusion injury decreased when glycocalyx components were better preserved in static conditions with preservation solution IGL-1, potentially due to the oncotic agent PEG35. These results were confirmed in dynamic preservation, with an improved liver protection when livers were subjected to hypothermic oxygenated perfusion (HOPE) before static cold storage. In pre-clinical settings, we also demonstrated that after 6h of normothermic perfusion, 3 out of 11 human livers, originally discarded for the transplantation, could have been potentially transplanted based on their viability criteria during perfusion.Better evaluation of hepatic graft preservation using glycocalyx, together with reducing the risks associated with marginal livers using normothermic perfusion machines, could help to meet the growing need for organs
Thomas, Cynthia W. "The lives of liver recipients in the long-term : a descriptive-exploratory study /". Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2008.
Znajdź pełny tekst źródłaTypescript. Includes bibliographical references (leaves 192-203). Free to UCD Anschutz Medical Campus. Online version available via ProQuest Digital Dissertations;
Niemelä, Onni. "Aminoterminal propeptide of type III procollagen and basement related antigens in alcoholic liver disease". Oulu : University of Oulu, 1985. http://catalog.hathitrust.org/api/volumes/oclc/14472875.html.
Pełny tekst źródłaSanders, Jennifer Ann. "Regulation of the c-Myc/Max/Mad network during liver development and regeneration /". View online version; access limited to Brown University users, 2005. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3174671.
Pełny tekst źródłaPike, Kenneth Charles. "Allocating life : the selection of liver transplant patients /". Thesis, Connect to this title online; UW restricted, 1996. http://hdl.handle.net/1773/8917.
Pełny tekst źródłaPoon, Tung-ping Ronnie. "Surgical strategies to improve long-term survival after hepatectomy for hepatocellular carcinoma". Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20933915.
Pełny tekst źródłaLo, Chung-mau. "Application of living donor liver transplantation to adult recipients in Hong Kong /". Hong Kong : University of Hong Kong, 1998. http://sunzi.lib.hku.hk/hkuto/record.jsp?B20017492.
Pełny tekst źródłaHuda, Amina. "Employment after liver transplantation". Diss., Search in ProQuest Dissertations & Theses. UC Only, 2010. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3398878.
Pełny tekst źródłaQuant, Patti A. "Control of liver ketogenesis". Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293878.
Pełny tekst źródłaJamieson, N. V. "Liver preservation for transplantation". Thesis, University of Cambridge, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.605054.
Pełny tekst źródłaGrover, Vijay Paul Bob. "Neuroimaging in liver disease". Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520951.
Pełny tekst źródłaAl-Nbaheen, May Salem. "Liver specific gene expression". Thesis, University of Bath, 2002. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.760790.
Pełny tekst źródłaBayard, Max, Jim Holt i Eileen Boroughs. "Nonalcoholic Fatty Liver Disease". Digital Commons @ East Tennessee State University, 2006. https://dc.etsu.edu/etsu-works/6487.
Pełny tekst źródłaTirnitz-Parker, Janina Elke Eleonore. "Primary culture and immortal cell lines as in vitro models to evaluate the role of TWEAK signalling in hepatic oval cells /". Connect to this title, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0039.
Pełny tekst źródłaAOKI, KUNIO, RYUICHIRO SASAKI i ZHU-MIN HUANG. "Trends in Mortality from Primary Liver Cancer, Cirrhosis of the Liver, Virus Hepatitis, and Other Liver Diseases 1968-1984 in Japan". Nagoya University School of Medicine, 1987. http://hdl.handle.net/2237/17497.
Pełny tekst źródłaCATALANO, GIORGIA. "Human liver stem cells and derived products in experimental models of liver ischemia reperfusion injury and of liver isolated normothermic perfusion". Doctoral thesis, Politecnico di Torino, 2018. http://hdl.handle.net/11583/2711047.
Pełny tekst źródłaLam, Shi. "The significance of hepatic stellate cell activation in small-for-size fatty liver graft injury /". View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B3829686X.
Pełny tekst źródłaFan, Sheung-tat. "Adult-to-adult live donor liver transplantation using right lobe graft : toward a perfect technical design /". Hong Kong : University of Hong Kong, 2002. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2520581x.
Pełny tekst źródłaWarren, Alessandra. "Hepatic sinusoidal cells in liver immunology and ageing". Thesis, The University of Sydney, 2005. https://hdl.handle.net/2123/27902.
Pełny tekst źródłaSöderdahl, Gunnar. "Liver transplantation and the role of adjuvant therapy for advanced primary liver tumours /". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-579-8/.
Pełny tekst źródłaAkingbasote, J. A. "The potential role of liver sinusoidal endothelial cells in drug-induced liver injury". Thesis, University of Liverpool, 2016. http://livrepository.liverpool.ac.uk/3005113/.
Pełny tekst źródłaYasuda, Katsutaro. "A nonhuman primate model of liver fibrosis towards cell therapy for liver cirrhosis". Kyoto University, 2020. http://hdl.handle.net/2433/258975.
Pełny tekst źródłaYamagami, Kazuhiko. "Heat shock preconditioning ameliorates liver injury following normothermic ischemia-reperfusion in steatotic rat livers". Kyoto University, 1999. http://hdl.handle.net/2433/181689.
Pełny tekst źródłaIbrahim, Sara [Verfasser], Achim [Akademischer Betreuer] Göpferich i Thomas S. [Akademischer Betreuer] Weiß. "The role of liver regeneration-associated protein ALR, Augmenter of Liver Regeneration, in cholestatic liver diseases / Sara Ibrahim ; Achim Göpferich, Thomas S. Weiß". Regensburg : Universitätsbibliothek Regensburg, 2019. http://d-nb.info/1201884012/34.
Pełny tekst źródłaBarnes, Mark Aaron Jr. "MACROPHAGE MIGRATION INHIBITORY FACTOR AND LIVER DISEASE: THE ROLE OF MIF IN ALCOHOL-INDUCED LIVER INJURY AND CARBON TETRACHLORIDE (CCI4)-INDUCED LIVER FIBROSIS". Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1396429556.
Pełny tekst źródłaKyriakides, Michael. "Metabolic phenotyping applied to pre-clinical drug induced liver injury and acute liver failure". Thesis, Imperial College London, 2014. http://hdl.handle.net/10044/1/29110.
Pełny tekst źródłaOrbach, Sophia Michelle. "Multi-Cellular Organotypic Liver Models for the Investigation of Chemical Toxicity and Liver Fibrosis". Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/93313.
Pełny tekst źródłaPh. D.
Maetani, Yoji. "Factors influencing liver regeneration following living-donor liver transplantation of the right hepatic lobe". Kyoto University, 2003. http://hdl.handle.net/2433/148765.
Pełny tekst źródłaKöhn, Julia. "Characterisation of liver progenitor cells and their microenvironment during chronic liver disease and hepatocarcinogenesis". Thesis, Curtin University, 2016. http://hdl.handle.net/20.500.11937/48824.
Pełny tekst źródłaGermani, Giacomo. "Predicting acute cellular rejection after liver transplantation: form liver function test to immune monitoring". Doctoral thesis, Università degli studi di Padova, 2013. http://hdl.handle.net/11577/3426180.
Pełny tekst źródłaLo scopo principale della terapia immunosoppressiva dopo trapianto di fegato è passato dalla prevenzione del rigetto acuto alla preservazione della funzionalità a lungo termine dell’organo trapiantato e alla prevenzione degli effetti collaterali dovuti alla terapia immunosoppressiva. Per perseguire tale scopo è necessaria una gestione ottimale della terapia immunosoppresiva stessa. Tuttavia, la misurazione dei livelli ematici dei farmaci immunosoppressori, generalmente utilizzati come surrogato dei livelli di immunosoppressione, non fornisce informazioni relative alla reale intensità della soppressione del sistema immunitario. Pertanto l’individuazione di marcatori biologici di rigetto acuto e/o di tolleranza risulta fondamentale per poter migliorare la gestione della terapia immunosoppressiva dopo-trapianto di fegato. Gli scopi degli studi riportati in questa tesi sono: 1) determinare l’incidenza e gli eventuali fattori di rischio di rigetto acuto dopo trapianto di fegato, valutare in che l’influenza del rigetto acuto e della sua severità istologica sulla sopravvivenza dell’organo e del paziente dopo trapianto di fegato; 2) valutare il ruolo degli indici di funzionalità epatica e della conta eosinofilica ematica come potenziali marcatori biologici di rigetto acuto dopo trapianto di fegato, in particolare di grado moderato/severo; 3) valutare, prima e dopo trapianto di fegato l’espressione di specifici marcatori immunologici di rigetto acuto. I risultati degli studi condotti hanno evidenziato come pazienti con diagnosi di rigetto acuto alla biopsia di protocollo presentino una sopravvivenza di organo e paziente, a 1, 5 e 10 anni dal trapianto di fegato, del tutto sovrapponibile a quella di pazienti senza evidenza istologica di rigetto acuto alla biopsia di protocollo. L’insorgenza di rigetto acuto di grado moderato/severo non sottoposto a trattamento farmacologico è tuttavia associata ad aumentata incidenza di decesso o perdita dell’organo post-trapianto. Nel valutare potenziali marcatori biologici di rigetto acuto, abbiamo dimostrato che nonostante la conta eosinofilica periferica non sia sufficientemente predittiva per lo sviluppo di rigetto acuto post-trapianto, la differenza nella conta eosinofilica tra la prima e la seconda biopsia epatica può essere considerato un fattore predittivo di miglioramento istologico, indipendentemente dall’utilizzo o meno di terapia con boli steroidei. Non è stata invece evidenziata alcuna associazione tra l’alterazione degli indici di funzionalità epatica e l’insorgenza di rigetto acuto. Infine, è stato dimostrato che l’insorgenza di rigetto acuto risulta associata ad aumentata espressione di CD28 e CD38 sia sui linfociti T CD4+ che CD8+ e ad un aumento dei livelli di IL-17. Tali alterazioni del sistema immunitario potrebbero essere utilizzate nella pratica clinica per valutare lo stato di soppressione del sistema immunitario in pazienti sottoposti a trapianto di fegato con il fine ultimo di una gestione ottimale e personalizzata della terapia immunooppressiva
Aguiar, Maria Ãsis Freire de. "Liver transplantation: the meaning for those that live the wait for the surgical procedure". Universidade Federal do CearÃ, 2007. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=626.
Pełny tekst źródłaO objetivo do transplante de fÃgado à aumentar a sobrevida de pacientes portadores de doenÃas hepÃticas irreversÃveis agudas e crÃnicas, alÃm de proporcionar melhor qualidade de vida. O interesse em prestar uma atenÃÃo em saÃde mais qualificada ao paciente em espera pelo transplante de fÃgado nos instigaram a nos aproximar mais da realidade vivenciada por ele, considerando que a compreensÃo da situaÃÃo vivida favorece uma assistÃncia mais humanizada e individualizada, contribuindo, ainda, para a construÃÃo do conhecimento em enfermagem e para a transformaÃÃo da prÃtica do enfermeiro. Objetivamos apreender o significado do transplante de fÃgado para o paciente em prÃ-transplante, atravÃs da caracterizaÃÃo dos pesquisados nos aspectos sÃcio-demogrÃficos e padrÃes clÃnicos; da identificaÃÃo dos sentimentos, crenÃas, valores e atitudes vivenciadas; e da identificaÃÃo de estratÃgias de enfrentamento para condiÃÃo vivenciada. Pesquisa de abordagem qualitativa, tendo como referencial teÃrico-metodolÃgico a Teoria HumanÃstica de Paterson e Zderad. Participaram do estudo dezoito pacientes inscritos no programa de transplante de fÃgado e acompanhados no Centro de Transplantes de FÃgado do Cearà â CTFC. Os dados foram coletados atravÃs de prontuÃrios, observaÃÃo nÃo-participante e entrevista. A anÃlise dos dados teve por base os preceitos do processo da Enfermagem FenomenolÃgica, utilizando quatro fases: a preparaÃÃo para vir-a-conhecer os pacientes que aguardam um transplante de fÃgado, conhecendo intuitivamente os pacientes, conhecendo cientificamente os pacientes e sÃntese complementar das realidades conhecidas. Desse processo, emergiram as unidades temÃticas com as categorias histÃria da doenÃa, sentimentos, enfrentando a condiÃÃo vivenciada, significado, expectativas e percepÃÃo do futuro. Identificamos o termo ânova vidaâ como a unidade de sentido de maior significÃncia para os informantes, designando um perÃodo diferente do que estÃo vivenciando atualmente e a necessidade de retornar suas atividades cotidianas e hÃbitos de vida relacionados à alimentaÃÃo, educaÃÃo, trabalho e lazer, resgatando assim sua autonomia e dignidade. O significado atribuÃdo ao transplante foi desvelado nÃo apenas como uma possibilidade de cura, mas a melhoria da qualidade de vida. Os pacientes revelaram o desejo de retribuir todo apoio recebido pela famÃlia durante esta fase crÃtica que vivenciam com a evoluÃÃo da doenÃa hepÃtica. A insuficiÃncia hepÃtica irreversÃvel à uma condiÃÃo patolÃgica de grande impacto na vida das pessoas, levando a necessidade de transplante de fÃgado como Ãnica possibilidade de reversÃo do quadro terminal, trazendo conseqÃÃncias diretas na qualidade de vida, com repercussÃes a nÃvel biolÃgico, psicolÃgico e social. As transformaÃÃes e limitaÃÃes impostas pela condiÃÃo crÃnica e pela necessidade de listagem para o transplante trazem a necessidade de adaptaÃÃo a uma nova realidade, tendo que se ajustarem as mudanÃas nos vÃrios campos da sua vida. Buscar o sentido e o significado que os pacientes atribuem à experiÃncia vivida no perÃodo prÃ-transplante à de suma importÃncia para o processo do cuidar, bem como conhecer suas histÃrias e experiÃncias vividas transcorridas em seu mundo, promovendo um ambiente assistencial mais humano.
Clèries, Soler Ramon. "Geographic Variability in Liver Cancer". Doctoral thesis, Universitat Autònoma de Barcelona, 2006. http://hdl.handle.net/10803/4627.
Pełny tekst źródłaThe first study, entitled "Meta-analysis of cohort studies of risk of liver cancer death among HBV carriers", evaluates the variability in PLC mortality reported in 11 cohort studies of male HBV carriers, taking into consideration the effects of geographic area and the choice of the general population versus a more comparable group such as HBV-negative workers or blood donors as the comparison group. The statistical methods of this study focuses on mixtures of Poisson distributions. The "stickbreaking" method has been used to estimate the number of components of the mixture of Poisson distributions, and, thus to obtain a pooled relative risk (RR) of death for PLC among male HBV carriers. The pooled RR of death by PLC related to HBV infection was 23.5 (95% Credibility Interval (CRI): 14.9 - 44.5). Studies carried out in high risk areas for PLC (China and Taiwan) showed RRs 2 to 5-fold higher than those of studies carried out in Europe, Japan and the U.S.. In low risk areas for PLC, studies which used workers or blood donors as comparison groups had RRs 1.9-fold higher (95% CRI: 1.2 - 3.1) than studies which used the general population. However, in high risk areas, the ratio of RRs was 5.3-fold (95% CRI: 3.4 - 7.9). This is the first time that a "healthy donor effect" has been quantified in longitudinal studies.
The second study, entitled "Geographic distribution of primary liver cancer in Europe in 2002" evaluates the effect of HBV and HCV seroprevalence in 38 European countries on PLC incidence and mortality. Mixed Poisson models based on Bayesian inference have been used to smooth Standardized Incidence (SIR) and Mortality (SMR) ratios for PLC accounting for the effect of HBV and HCV prevalences. This approach enabled us to both examine the effect of different levels of HBV and HCV, and to identify remaining variability in PLC after accounting for infection rates. Bayesian inference allowed the determination of posterior probabilities for the somoothed SIRs and SMRs (hereafter RRs). The Deviance Information Criterion (DIC) and the "effective number of parameters" (pD) have been used as tools for model choice. The highest mortality and incidence PLC RRs were found in Southern European countries (RR range 0.9-2.4), whereas Northern European countries showed the lowest RRs (RR range: 0.3-0.9). The effect of HBV infection was not found to be statistically significant in the model which accounted for both HBV and HCV prevalence. Countries with a prevalence of HCV higher than 2% (e.g.: Italy and Spain) had a higher risk of incidence and mortality (RR range: 1.28 - 1.78) than countries with HCV prevalence below 1%. Thus, the high risk of PLC detected in Southern Europe appears to be explained, in part, by HCV infection. The high HCV seroprevalence in this area could be associated with exposure 30-50 years ago. There may be an underestimation of PLC incidence and mortality rates in Eastern European countries given the low PLC RRs reported, despite high HBV and HCV seroprevalences observed. The implementation of population-based cancer registries in Eastern European countries is warranted, as well as HCV prevalence studies across Europe, to better determine the distribution of PLC in Europe and its relationship with that virus.
The last study, entitled "Time trends in liver disease in Spain during the period 198397", describes incidence and mortality trends in hepatocellular carcinoma and cholangiocarcinoma as well as mortality trends in liver cirrhosis in Spain. Autoregressive age-period-cohort (APC) models have been used to evaluate the time trends. We found that APC models performed well for those liver diseases with large number of cases, whereas the age-period models did for those liver diseases with low number of cases. We found an increase in incidence and mortality of hepatocellular carcinoma in Spain (annual percent change (APCH) in men's incidence: 6.6%, 95% CRI: 5.8, 8.1: APCH in women's incidence: 4.5%, 95% CRI: 1.4%, 7.3%; APCH in men's mortality: 6.8%, 95% CRI: 5.8%, 8.1%; APCH in women's mortality: 5.1%, 95% CRI: 3.5%, 6.3%), that appear to be related to HCV exposure 30 years ago, as described in other studies of PLC. We also found an increasing trend in cholangiocarcinoma mortality (APCH in men: 17.1%, 95% CRI: 13.5%, 21.2%; APCH in women: 15.0%, 95% CRI: 11.5%, 19.5%) similar to that found in some developed countries, that could be attributed to improvement in diagnosis resulting from better imaging and diagnostic techniques. However, we did not detect a significant increasing trend in cholangiocarcinoma incidence, perhaps due to the low number of cases reported by the Spanish cancer registries. We have observed a decreasing trend in cirrhosis mortality in both sexes during the study period (APCH in men: -3.1%, 95% CRI: -5.1, -1.9%; APCH in women: -2.9%; 95% CRI: -6.2%, -1.3%), although younger cohorts did not show this pattern. This cohort effect suggests the possibility that younger cohorts could be exposed to some additional risk factors besides alcohol consumption. HIV and HCV or HBV co-infection and intravenous drug addiction could explain the increase in liver cirrhosis mortality among younger cohorts.
The flexibility of the Bayesian approach allowed us to cope with extra-Poisson variability in three statistical analyses, applying different models, and addressing relevant methodological aspects specific to each problem. Challenging statistical issues in the framework of Bayesian applied modelling are: i) the selection of prior distributions for model parameters, which is related to convergence of the model; and ii) model selection procedures, and these remain important considerations for future research.
Tacon, Geoffrey Reginald Russell. "Mathematical modelling of liver kinetics /". [St. Lucia, Qld.], 2005. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe19399.pdf.
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