Gotowe bibliografie tematyczne / Liver cells

Gotowa bibliografia na temat „Liver cells”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 29 lipca 2024

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Artykuły w czasopismach na temat "Liver cells"

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PD, Gupta. "Liver Cells Can Dedifferentiate and Act as Progenitor Cells for Liver Growth". Journal of Embryology & Stem Cell Research 3, nr 2 (2019): 1–2. http://dx.doi.org/10.23880/jes-16000124.

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Seki, Shuhji, Hiroyuki Nakashima, Masahiro Nakashima i Manabu Kinoshita. "Antitumor Immunity Produced by the Liver Kupffer Cells, NK Cells, NKT Cells, and CD8+CD122+T Cells". Clinical and Developmental Immunology 2011 (2011): 1–11. http://dx.doi.org/10.1155/2011/868345.

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Mouse and human livers contain innate immune leukocytes, NK cells, NKT cells, and macrophage-lineage Kupffer cells. Various bacterial components, including Toll-like receptor (TLR) ligands and an NKT cell ligand (α-galactocylceramide), activate liver Kupffer cells, which produce IL-1, IL-6, IL-12, and TNF. IL-12 activates hepatic NK cells and NKT cells to produce IFN-γ, which further activates hepatic T cells, in turn activating phagocytosis and cytokine production by Kupffer cells in a positive feedback loop. These immunological events are essentially evoked to protect the host from bacterial and viral infections; however, these events also contribute to antitumor and antimetastatic immunity in the liver by activated liver NK cells and NKT cells. Bystander CD8+CD122+T cells, and tumor-specific memory CD8+T cells, are also induced in the liver byα-galactocylceramide. Furthermore, adoptive transfer experiments have revealed that activated liver lymphocytes may migrate to other organs to inhibit tumor growth, such as the lungs and kidneys. The immunological mechanism underlying the development of hepatocellular carcinoma in cirrhotic livers in hepatitis C patients and liver innate immunity as a double-edged sword (hepatocyte injury/regeneration, septic shock, autoimmune disease, etc.) are also discussed.
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Wu, Xian, Yongyan Chen, Haiming Wei, Rui Sun i Zhigang Tian. "Development of Murine Hepatic NK Cells during Ontogeny: Comparison with Spleen NK Cells". Clinical and Developmental Immunology 2012 (2012): 1–12. http://dx.doi.org/10.1155/2012/759765.

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The phenotype of developing liver NK cells (CD3−NK1.1+) was investigated during mouse ontogeny comparing with spleen NK cells. The highest percentage of hepatic CD27−CD11b−NK cells occurred at the fetal stage. After birth, the percentage of CD27−CD11b−NK cells in both the liver and spleen gradually decreased to their lowest level at 6 weeks. More CD27+CD11b−NK cells were detected in the liver than that in spleen from week 1 to 6. Expression of NKG2A on liver NK cells was decreased but still much higher than that of spleen NK cells after 1 week. The NKG2D expression on liver NK cells increased to its highest level and was significantly higher than on spleen NK cells till 4 weeks. During mouse ontogeny, weaker expression of NKp46 and CD2 and stronger expression of CD69, CD11c, 2B4, and CD73 were observed on liver NK cells. Furthermore, neonatal liver NK cells express higher IFN-γ and perforin than adult .These results suggest that the maturation process of NK cells is unique in the livers, and liver microenvironments might play critical roles to keep NK cells in an immature status.
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Belaschk, Elisa, Susanne Rohn, Ramla Mukiibi, Anja Reutzel-Selke, Peter Tang, Birgit Sawitzki, Johann Pratschke, Igor M. Sauer i Martina T. Mogl. "Isolation, Characterization and Cold Storage of Cells Isolated from Diseased Explanted Livers". International Journal of Artificial Organs 40, nr 6 (23.05.2017): 294–306. http://dx.doi.org/10.5301/ijao.5000594.

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Introduction Livers discarded after standard organ retrieval are commonly used as a cell source for hepatocyte transplantation. Due to the scarcity of organ donors, this leads to a shortage of suitable cells for transplantation. Here, the isolation of liver cells from diseased livers removed during liver transplantation is studied and compared to the isolation of cells from liver specimens obtained during partial liver resection. Methods Hepatocytes from 20 diseased explanted livers (Ex-group) were isolated, cultured and stored at 4°C for up to 48 hours, and compared to hepatocytes isolated from the normal liver tissue of 14 liver lobe resections (Rx-group). The nonparenchymal cell fraction (NPC) was analyzed by flow cytometry to identify potential liver progenitor cells, and OptiPrep™ (Sigma-Aldrich) density gradient centrifugation was used to enrich the progenitor cells for immediate transplantation. Results There were no differences in viability, cell integrity and metabolic activity in cell culture and survival after cold storage when comparing the hepatocytes from the Rx-group and the Ex-group. In some cases, the latter group showed tendencies of increased resistance to isolation and storage procedures. The NPC of the Ex-group livers contained considerably more EpCAM+ and significantly more CD90+ cells than the Rx-group. Progenitor cell enrichment was not sufficient for clinical application. Conclusions Hepatocytes isolated from diseased explanted livers showed the essential characteristics of being adequate for cell transplantation. Increased numbers of liver progenitor cells can be isolated from diseased explanted livers. These results support the feasibility of using diseased explanted livers as a cell source for liver cell transplantation.
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Jauregui, Hugo O., Namita Roy Chowdhury i Jayanta Roy Chowdhury. "Use of Mammalian Liver Cells for Artificial Liver Support". Cell Transplantation 5, nr 3 (maj 1996): 353–67. http://dx.doi.org/10.1177/096368979600500302.

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Advances in orthotopic liver transplantation have improved the survival rate of both acute and chronic liver failure patients to nearly 70%. However, the success of this treatment modality has created an international organ shortage. Many patients die while awaiting transplantation in part due to the minimal capacity to store viable transplantable livers beyond 24 h. Additionally, for many areas of the world, routine use of whole liver transplantation to treat liver disease is impractical due to the demands on both financial and technical resources. Potentially, these issues may be alleviated, at least in part, by the use of liver cell transplantation or cellular-based liver assist devices. The well-documented regenerative capacity of the liver may obviate the need for whole organ transplantation in some instances of acute failure, if the patient may be provided temporary metabolic support. Although other patients ultimately may require transplantation, a longer period of time to find a suitable organ for transplantation may be gained by that supportive therapy. The field of liver cell transplantation may offer solutions to patients with inherited metabolic deficiencies or chronic liver disease. The potential to treat an hepatic disorder by using only a fraction of the whole liver would increase the number of whole organs available for orthotopic liver transplantation. Research in the fields of hepatocyte based intra- and extra-corporeal liver support is providing evidence that these therapeutic modalities may ultimately become routine in the treatment of severe liver disease. A historic overview of that technology along with its current status is discussed.
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Shafritz, David A., Mo R. Ebrahimkhani i Michael Oertel. "Therapeutic Cell Repopulation of the Liver: From Fetal Rat Cells to Synthetic Human Tissues". Cells 12, nr 4 (6.02.2023): 529. http://dx.doi.org/10.3390/cells12040529.

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Progenitor cells isolated from the fetal liver can provide a unique cell source to generate new healthy tissue mass. Almost 20 years ago, it was demonstrated that rat fetal liver cells repopulate the normal host liver environment via a mechanism akin to cell competition. Activin A, which is produced by hepatocytes, was identified as an important player during cell competition. Because of reduced activin receptor expression, highly proliferative fetal liver stem/progenitor cells are resistant to activin A and therefore exhibit a growth advantage compared to hepatocytes. As a result, transplanted fetal liver cells are capable of repopulating normal livers. Important for cell-based therapies, hepatic stem/progenitor cells containing repopulation potential can be separated from fetal hematopoietic cells using the cell surface marker δ-like 1 (Dlk-1). In livers with advanced fibrosis, fetal epithelial stem/progenitor cells differentiate into functional hepatic cells and out-compete injured endogenous hepatocytes, which cause anti-fibrotic effects. Although fetal liver cells efficiently repopulate the liver, they will likely not be used for human cell transplantation. Thus, utilizing the underlying mechanism of repopulation and developed methods to produce similar growth-advantaged cells in vitro, such as human induced pluripotent stem cells (iPSCs). This approach has great translational potential for developing novel cell-based therapies in patients with liver disease. The present review gives a brief overview of the classic cell transplantation models and various cell sources studied as donor cell candidates. The advantages of fetal liver-derived stem/progenitor cells are discussed, as well as the mechanism of liver repopulation. Moreover, this article reviews the potential of in vitro developed synthetic human fetal livers from iPSCs and their therapeutic benefits.
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Jang, Ju Wang, Eric B. Richardson, Sunhoo Park i Seung Bum Lee. "Liver Stem Cells". Hanyang Medical Reviews 34, nr 4 (2014): 145. http://dx.doi.org/10.7599/hmr.2014.34.4.145.

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&NA;. "Sinusoidal Liver Cells". Journal of Pediatric Gastroenterology and Nutrition 4, nr 2 (kwiecień 1985): 335–36. http://dx.doi.org/10.1097/00005176-198504000-00039.

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Matthews, Vance, i George Yeoh. "Liver Stem Cells". IUBMB Life (International Union of Biochemistry and Molecular Biology: Life) 57, nr 8 (1.08.2005): 549–53. http://dx.doi.org/10.1080/15216540500215606.

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Sell, S. "Liver stem cells". Science 260, nr 5112 (28.05.1993): 1224. http://dx.doi.org/10.1126/science.8493561.

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Rozprawy doktorskie na temat "Liver cells"

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Wu, Yue. "Generating Beta-cells from liver cells". Thesis, King's College London (University of London), 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.420423.

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Tirnitz-Parker, Janina Elke Eleonore. "Primary culture and immortal cell lines as in vitro models to evaluate the role of TWEAK signalling in hepatic oval cells /". Connect to this title, 2007. http://theses.library.uwa.edu.au/adt-WU2008.0039.

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Harrison, Sean. "Liver cell types derived from pluripotent stem cells". Thesis, University of Manchester, 2014. https://www.research.manchester.ac.uk/portal/en/theses/liver-cell-types-derived-from-pluripotent-stem-cells(7f39c3ec-facd-4c06-ab9a-7c171313eb05).html.

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Liver development involves the differentiation and interaction of both endoderm and mesoderm cell types. The role of the liver in drug metabolism makes it an important area of medical research. Mimicking embryonic liver development in vitro using human ESCs is a strategy used to differentiate liver cell types. These can then be used as a model playing a role in the development of drugs and the study of their hepatotoxicity and would also have potential for use in cell therapy and regenerative medicine. Differentiated hepatocyte-like cells were found to have more in common with liver cells than those of other organs, including the secretion of albumin and activity of proteins important in drug metabolism, CYP3A and CYP2D6. However the hepatocyte-like cells were found to more closely resemble fetal rather than adult hepatocytesOrganoid differentiation resulted in cells types which in vivo are both endoderm and mesoderm derived cells of the liver. Culture in this 3D system allowed the spontaneous acquisition of polarity by these cells and their formation into structures reminiscent of liver architecture. After treatment with the toxin 4,4′-diaminodiphenylmethane a cell type and structure specific dose response was observed which matches that described in vivo.
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Lam, Shuk-pik. "Differentiation of mesenchymal stem cells (MSCs) into hepatocytes in acute liver injury". Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43085647.

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Warren, Alessandra. "Hepatic sinusoidal cells in liver immunology and ageing". Thesis, The University of Sydney, 2005. https://hdl.handle.net/2123/27902.

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The liver has a key role both from a metabolic and an immunological viewpoint. It is involved in the metabolism, or degradation of different molecules absorbed by the intestine, including xenobiotics, drugs and lipids, the synthesis and turnover of plasma proteins, the production of bile and the storage of glycogen and vitamin A. Unique amongst solid organs, the sinusoidal endothelium of the liver is perforated with pores, or fenestrations, and is not separated from hepatocytes by a basal lamina. It has been proposed that the fenestrations, also termed the ’liver sieve’, function as a bio-filter allowing free diffusion of small molecules (less than 100 nm in diameter) from the blood to the hepatocytes and Vice versa. Changes in these structures, as seen in ageing, could have important effects on hepatic function and in particular lipid metabolism. The liver also has unique immunological functions including T-cell activation and tolerance. This thesis explores potential new roles of the fenestrated sinusoidal endothelium in some aspects of liver immunology and ageing.
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Bird, Thomas Graham. "Liver regeneration by hepatic progenitor cells". Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5634.

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The liver is the largest solid organ in the body and is frequently the site of injury. During disease, liver injury is usually compensated for by exceptionally efficient regeneration which occurs both from differentiated epithelia and also from an undifferentiated cell population with stem cell like qualities known as hepatic progenitor cells (HPCs). HPCs are particularly active during massive or chronic liver injury and therefore are an attractive target for much needed novel therapies to enhance regeneration in patients for whom the only current effective therapy is liver transplantation. Stem cells in other organs systems are believed to reside in a specialised microenvironment or niche which supports their maintenance and function. To investigate the hypothesis that HPCs are supported by a functional niche and are capable of regenerating hepatocytes, we commenced by establishing a number of murine in vivo models. Having shown a stereotypical niche, consisting of macrophages, myofibroblasts and laminin exists in both animal models and human disease, we investigated the active recruitment of extrahepatic cells into this niche and showed that macrophages are actively recruited from the bone marrow during liver injury. Macrophages were shown to influence HPC behaviour during injury. Furthermore using macrophages as a cellular therapy, induced HPC activation with corresponding changes to liver structure and function. Investigation of signalling pathways revealed and confirmed a TWEAK dependent activation of HPCs following macrophage transfer. Having demonstrated the potential for macrophage therapy via HPC activation, we aimed to study the ability of HPCs to regenerate the hepatic parenchyma. To do so we developed and characterised a novel model of hepatocellular injury and HPC activation. Using the genetic labeling of hepatocytes in this model we were able to show rapid and large scale repopulation of hepatocytes from a precursor source with HPCs being the critical precursor source of hepatocellular regeneration. In addition this process is again dependent on TWEAK signalling, without which HPC mediated regeneration fails resulting in mortality. Therefore HPCs are an attractive biological target for regenerative medicine, and both TWEAK signalling and autologous macrophage infusion offer genuine potential to manipulate these cells as future therapies.
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Cheluvappa, Rajkumar. "Pathophysiology of Liver Sinusoidal Endothelial Cells". Thesis, The University of Sydney, 2008. http://hdl.handle.net/2123/2802.

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Owing to its strategic position in the liver sinusoid, pathologic and morphologic alterations of the Liver Sinusoidal Endothelial Cell (LSEC) have far-reaching repercussions for the whole liver and systemic metabolism. LSECs are perforated with fenestrations, which are pores that facilitate the transfer of lipoproteins and macromolecules between blood and hepatocytes. Loss of LSEC porosity is termed defenestration, which can result from loss of fenestrations and/ or decreases in fenestration diameter. Gram negative bacterial endotoxin (Lipopolysaccharide, LPS) has marked effects on LSEC morphology, including induction LSEC defenestration. Sepsis is associated with hyperlipidemia, and proposed mechanisms include inhibition of tissue lipoprotein lipase and increased triglyceride production by the liver. The LSEC has an increasingly recognized role in hyperlipidemia. Conditions associated with reduced numbers of fenestrations such as ageing and bacterial infections are associated with impaired lipoprotein and chylomicron remnant uptake by the liver and consequent hyperlipidemia. Given the role of the LSEC in liver allograft rejection and hyperlipidemia, changes in the LSEC induced by LPS may have significant clinical implications. In this thesis, the following major hypotheses are explored: 1. The Pseudomonas aeruginosa toxin pyocyanin induces defenestration of the LSEC both in vitro and in vivo 2. The effects of pyocyanin on the LSEC are mediated by oxidative stress 3. Defenestration induced by old age and poloxamer 407 causes intrahepatocytic hypoxia and upregulation of hypoxia-related responses 4. Defenestration of the LSEC seen in old age can be exacerbated by diabetes mellitus and prevented or ameliorated by caloric restriction commencing early in life
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Cheluvappa, Rajkumar. "Pathophysiology of Liver Sinusoidal Endothelial Cells". University of Sydney, 2008. http://hdl.handle.net/2123/2802.

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Doctor of Philosophy(PhD)
Owing to its strategic position in the liver sinusoid, pathologic and morphologic alterations of the Liver Sinusoidal Endothelial Cell (LSEC) have far-reaching repercussions for the whole liver and systemic metabolism. LSECs are perforated with fenestrations, which are pores that facilitate the transfer of lipoproteins and macromolecules between blood and hepatocytes. Loss of LSEC porosity is termed defenestration, which can result from loss of fenestrations and/ or decreases in fenestration diameter. Gram negative bacterial endotoxin (Lipopolysaccharide, LPS) has marked effects on LSEC morphology, including induction LSEC defenestration. Sepsis is associated with hyperlipidemia, and proposed mechanisms include inhibition of tissue lipoprotein lipase and increased triglyceride production by the liver. The LSEC has an increasingly recognized role in hyperlipidemia. Conditions associated with reduced numbers of fenestrations such as ageing and bacterial infections are associated with impaired lipoprotein and chylomicron remnant uptake by the liver and consequent hyperlipidemia. Given the role of the LSEC in liver allograft rejection and hyperlipidemia, changes in the LSEC induced by LPS may have significant clinical implications. In this thesis, the following major hypotheses are explored: 1. The Pseudomonas aeruginosa toxin pyocyanin induces defenestration of the LSEC both in vitro and in vivo 2. The effects of pyocyanin on the LSEC are mediated by oxidative stress 3. Defenestration induced by old age and poloxamer 407 causes intrahepatocytic hypoxia and upregulation of hypoxia-related responses 4. Defenestration of the LSEC seen in old age can be exacerbated by diabetes mellitus and prevented or ameliorated by caloric restriction commencing early in life
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Ma, Kwai-yee Stephanie. "Identification and characterization of tumorigenic liver cancer stem/progenitor cells". Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39557534.

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Poli, G. "Biochemical studies on CC14̲-induced liver injury using isolated rat liver cells". Thesis, Brunel University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.379250.

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Książki na temat "Liver cells"

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Sell, Stewart. Liver stem cells. Austin: Landes Bioscience, 1997.

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Ochiya, Takahiro, red. Liver Stem Cells. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-61779-468-1.

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N, Berry Michael, i Edwards Anthony M, red. The hepatocyte review. Dordrecht: Kluwer Academic Publishers, 2000.

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1932-, Tanikawa Kyuichi, i Ueno T. 1951-, red. Liver diseases and hepatic sinusoidal cells. Tokyo: Springer, 1999.

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ussinger, D. Ha. Liver regeneration. Berlin: de Gruyter, 2011.

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International, Kupffer Cell Symposium (3rd 1985 Strasbourg France). Cells ofthe hepatic sinusoid. Rijwsojk, The Netherlands: Kupffer Cell Foundation, 1986.

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International Symposium on "Liver Cells and Drugs" (1987 Rennes, France). Liver cells and drugs: Proceedings of the International Symposium on Liver Cells and Drugs, held in Rennes on July 7-10, 1987. Paris: Editions INSERM, 1988.

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David, Heinz. The hepatocyte: Development, differentation, and ageing. Jena: VEB Gustav Fischer, 1985.

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1931-, Mito Michio, i Sawa Masayuki, red. Hepatocyte transplantation. Basel: Karger Landes Systems, 1997.

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D, Lukʹi͡a︡nova L., Gulak P. V i Akademii͡a︡ nauk SSSR. Otdelenie fiziologii., red. Gepatot͡s︡it: Funkt͡s︡ionalʹno-metabolicheskie svoĭstva. Moskva: "Nauka", 1985.

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Części książek na temat "Liver cells"

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Carpino, Guido, Sergio Morini, Simone Carotti i Eugenio Gaudio. "Hepatic Progenitor Cells and Biliary Tree Stem Cells". W Liver Diseases, 29–35. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-24432-3_3.

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Itoh, Tohru, Cindy Yuet-Yin Kok, Hinako M. Takase i Atsushi Miyajima. "Liver Stem Cells". W Regenerative Medicine - from Protocol to Patient, 209–40. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-27610-6_8.

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Itoh, Tohru, Minoru TanakaTanaka i Atsushi Miyajima. "Liver Stem Cells". W Regenerative Medicine, 327–49. Dordrecht: Springer Netherlands, 2010. http://dx.doi.org/10.1007/978-90-481-9075-1_14.

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Itoh, Tohru, Hinako Takase, Minoru Tanaka i Atsushi Miyajima. "Liver Stem Cells". W Regenerative Medicine, 337–63. Dordrecht: Springer Netherlands, 2013. http://dx.doi.org/10.1007/978-94-007-5690-8_13.

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Winwood, Paul J., i Michael J. P. Arthur. "Kupffer cells and endothelial cells". W Liver Growth and Repair, 482–511. Dordrecht: Springer Netherlands, 1998. http://dx.doi.org/10.1007/978-94-011-4932-7_19.

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Russo, Francesco Paolo, Patrizia Burra i Maurizio Parola. "Adult Liver Stem Cells". W Adult Stem Cells, 319–38. New York, NY: Springer New York, 2013. http://dx.doi.org/10.1007/978-1-4614-9569-7_13.

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Caligiuri, Alessandra, i Fabio Marra. "Stellate cells". W Signaling Pathways in Liver Diseases, 34–60. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118663387.ch3.

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Kiyani, Amirali, i Ekihiro Seki. "Kupffer cells". W Signaling Pathways in Liver Diseases, 61–72. Chichester, UK: John Wiley & Sons, Ltd, 2015. http://dx.doi.org/10.1002/9781118663387.ch4.

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Marra, Fabio, Sara Galastri, Sara Aleffi i Massimo Pinzani. "Stellate Cells". W Signaling Pathways in Liver Diseases, 41–68. Berlin, Heidelberg: Springer Berlin Heidelberg, 2009. http://dx.doi.org/10.1007/978-3-642-00150-5_3.

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Gonzalez, Raul S., i Kay Washington. "Funny-Looking Cells". W Non-Neoplastic Liver Pathology, 203–10. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-31424-2_13.

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Streszczenia konferencji na temat "Liver cells"

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Hay, David. "Building Implantable Human Liver Tissue from Pluripotent Stem Cells". W Cells 2023. Basel Switzerland: MDPI, 2023. http://dx.doi.org/10.3390/blsf2023021016.

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Safwan-Zaiter, Hasan, Kay-Dietrich Wagner i Nicole Wagner. "The Senescence Marker p16Ink4a—A Player of Liver Endothelial Cells Physiology". W Cells 2023. Basel Switzerland: MDPI, 2023. http://dx.doi.org/10.3390/blsf2023021013.

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dos Santos, Diego Dias, Nycole Morelli Belote, Rafael André da Silva, Adriana Aparecida Ferraz Carbonel, Gisela Rodrigues da Silva Sasso i Cristiane Damas Gil. "Role of Gal-3 on Cisplatin-Induced Acute Liver Injury Model". W Cells 2023. Basel Switzerland: MDPI, 2023. http://dx.doi.org/10.3390/blsf2023021011.

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Kang, Young Bok (Abraham), Joseph Cirillo, Siddhartha Rawat, Michael Bouchard i Hongseok (Moses) Noh. "Layered Hepatocytes and Endothelial Cells on a Transwell Membrane: Toward Engineering the Liver Sinusoid". W ASME 2012 International Mechanical Engineering Congress and Exposition. American Society of Mechanical Engineers, 2012. http://dx.doi.org/10.1115/imece2012-89413.

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This paper presents a novel liver model platform that mimics the liver sinusoid, a functional unit of the liver where most liver activities occur. A key component of the current liver model is a layered co-culture of primary rat hepatocytes (PRH) and primary rat liver sinusoidal endothelial cells (LSEC) or a bovine aortic endothelial cells (BAEC) as an alternative. Poly-dimethylsiloxane (PDMS) microchannels were fabricated and attached to transwell membranes that contain submicroscale pores. Cells were cultured either on one side or on both sides of the transwell membrane, and in both cases cells formed confluent layers. A thin matrigel coating or micro porous membrane was applied between the two cell layers in order to mimic the Space of Disse. We used three different methods to check cell viability: recombinant adenovirus expressing green fluorescent protein, mito-tracker red to stain live mitochondria, and an expression plasmid expressing red fluorescent protein (RFP). It was shown that PRH retained normal morphology and remained viable for about 3 days with BAEC in the PDMS microchannel, about 57 days with BAEC on the transwell, and about 39 days with primary LSEC on the transwell. Preliminary observation suggests that there is formation of structures between hepatocytes that appear similar to bile canaliculi when PRH are co-cultured with endothelial cells. The layered co-culture system seems to be a promising method to generate accurate liver models.
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Lam, WLM, G. Gabernet, T. Poth, K. Wolff, A. de Ponti, S. Nahnsen, A. Soborowski, D. Schneller i P. Angel. "RAGE signaling in liver progenitor cells affects fibrosis upon liver injury". W 36. Jahrestagung der Deutschen Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag KG, 2020. http://dx.doi.org/10.1055/s-0039-3402122.

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Chen, Wan-Ting, Chun-Chih Tseng, Kyle Pfaffenbach, Gary Kanel, Biquan Luo, Bangyan L. Stiles i Amy S. Lee. "Abstract B09: Liver-specific knockout of GRP94 in mice disrupts cell adhesion, activates liver progenitor cells, and accelerates liver tumorigenesis". W Abstracts: Third AACR International Conference on Frontiers in Basic Cancer Research - September 18-22, 2013; National Harbor, MD. American Association for Cancer Research, 2013. http://dx.doi.org/10.1158/1538-7445.fbcr13-b09.

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Ma, Liang, Jeremy Barker, Changchun Zhou, Biaoyang Lin i Wei Li. "A Perfused Two-Chamber System for Anticancer Drug Screening". W ASME 2010 International Manufacturing Science and Engineering Conference. ASMEDC, 2010. http://dx.doi.org/10.1115/msec2010-34326.

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A cell culture microfluidic device has been developed to test the cytotoxicity of anticancer drugs while reproducing multi-organ interactions in vitro. Cells were cultured in separate chambers representing the liver and tumor. The two chambers were connected through a channel to mimick the blood flow. Glioblastoma (GBM) cancer cells (M059K) and hepatoma cells (HepG2) were cultured in the tumor and the liver chambers, respectively. The cytotoxic effect of cancer treatment drug Temolozomide (TMZ) was tested using this two chamber system. The experimental results showed that with the liver cells, the cancer cells showed much higher viability than those without the liver cells. This indicates that the liver metabolism has strong effect on the toxicity of the anticancer drug. The results demonstrated that the perfused two chamber cell culture system has the potential to be used as a platform for drug screening in a more physiologically realistic environment.
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Bosch, Miriam, Nina Kallin, SainitinDonakondaSainitin Donakonda, Ulrike Protzer, Dietmar Zehn, Dirk Wohlleber i Percy Knolle. "Dysfunctional liver-resident CXCR6+ CD8 T cells during persistent viral liver infection". W 38. Jahrestagung der Deutsche Arbeitsgemeinschaft zum Studium der Leber. Georg Thieme Verlag, 2022. http://dx.doi.org/10.1055/s-0041-1740811.

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Fakhar-e-Alam, M., Syed M. Usman Ali, S. Ali, S. Firdous, M. Atif, Z. H. Ibupoto, M. Willander, M. Kashif i U. Hashim. "Photodynamic damage in liver carcinoma HepG2 cells". W 2012 International Conference on Biomedical Engineering (ICoBE). IEEE, 2012. http://dx.doi.org/10.1109/icobe.2012.6179012.

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Harrison, R. "HUMAN HEPATIC ENDOTHELIAL CELLS AND HEPATOCYTES IN CULTURE: MORPHOLOGICAL FEATURES, AND PRODUCTION OF VON WILLEBRAND FACTOR AND FIBRINOGEN". W XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1643350.

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Liver cells were derived from cadaveric organ donors. Pieces of human liver 5 to 50 grams were minced, washed, and incubated in collagenase at 37 degrees C. After washing, the cell suspension was plated into culture vessels that had been briefly pre-treated with an extract derived from human liver. A mixed population of liver cells, including endothelial cells, hepatocytes, and Kupffer cells, attached within hours. At the end of 2 to 3 weeks there developed clusters of densely packed cells of two types. The most numerous cells were initially fusiform but grew as a monolayer even when densely packed. As density increased they assumed a polygonal form; cells with this morphological appearance stained immunocytochemically for von Willebrand factor antigen. They were relatively small and resembled cells derived from human umbilical vein except that the cytoplasm was more filmy in appearance. The second prominent cell type was significantly larger and likewise replicated to form clusters. These large cells sometimes contained multiple nuclei, exhibited a relatively low nuclear to cytoplasmic ratio, and immunocytochemically stained for human fibrinogen. A more distinct nuclear membrane and prominent nucleoli were characteristics of hepatocytes that were useful light microscopically in distinguishing these cells from sinusoidal endothelial cells. Ultrastructurally, endothelial cells were characterized by small size, holes in and among the cells that probably were the in vitro analogue of fenestrae, and numerous Weibel-Palade bodies in the cytoplasm, which otherwise was relatively bland. Hepatocytes, by contrast, had an active appearing cytoplasm containing more organelles. Canaliculi and typical tight junctions formed between adjacent hepatocytes. Levels of vWF and fibrinogen increased in a time dependent manner in media overlying this mixed population of cells. Human factor VIII has not yet been detected in the media overlying these mixed cells derived from human liver, and factor VIII antigen has not yet been demonstrable immunocytochemically in either cell type.
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Raporty organizacyjne na temat "Liver cells"

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Jin, Dachuan, Zhongfeng Cui, Tao Zhou, Baoqiang Guo, Shunqin Jin, Guangming Li i Chunming Zhang. Comparison of therapeutic effects of various stem cell types, sources, and routes of administration on chronic decompensated cirrhosis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, styczeń 2023. http://dx.doi.org/10.37766/inplasy2023.1.0050.

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Review question / Objective: The aim of this study was to compare the therapeutic effects of various stem cell types, sources and routes of administration on chronic decompensated cirrhosis by using network meta-analysis. Condition being studied: Liver cirrhosis is an important public health problem that puzzles the world. It is divided into compensatory stage and decompensated stage. Once the patient enters decompensated stage, the treatment is very limited, and liver transplantation is currently the best and only approach to improve the survival rate of decompensated cirrhosis4. However, liver transplantation is difficult to be widely applied due to the lack of donor organs and high cost. Therefore, it is very important to study the alternative treatment of liver transplantation. Stem cell therapy as a promising frontier treatment for decompensated cirrhosis, is becoming one of the best feasible alternatives to liver transplantation in recent 20 years. It is very important and necessary to optimize the factors such as cell sources, types, and delivery route, etc. before taking stem cell therapy as a routine clinical treatment. It is believed that the network meta-analysis of the efficacy of various types of stem cells from different sources and routes of administration in the treatment of chronic decompensated cirrhosis can provide useful very clues for clinical practice.
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Li, Jing. Effects of oxymatrine on the proliferation of human liver cancer Bel-7404 cells: a protocol of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review Protocols, kwiecień 2020. http://dx.doi.org/10.37766/inplasy2020.4.0026.

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Li, Jing. Effects of artemisinin on proliferation and apoptosis of human liver cancer HepG2 cells: a protocol of systematic review and meta-analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, kwiecień 2020. http://dx.doi.org/10.37766/inplasy2020.4.0075.

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Shapira, Roni, Judith Grizzle, Nachman Paster, Mark Pines i Chamindrani Mendis-Handagama. Novel Approach to Mycotoxin Detoxification in Farm Animals Using Probiotics Added to Feed Stuffs. United States Department of Agriculture, maj 2010. http://dx.doi.org/10.32747/2010.7592115.bard.

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T-2 toxin, a toxic product belongs to the trichothecene mycotoxins, attracts major interest because of its severe detrimental effects on the health of human and farm animals. The occurrence of trichothecenes contamination is global and they are very resistant to physical or chemical detoxification techniques. Trichothecenes are absorbed in the small intestine into the blood stream. The hypothesis of this project was to develop a protecting system using probiotic bacteria that will express trichothecene 3-O-acetyltransferase (Tri101) that convert T-2 to a less toxic intermediate to reduce ingested levels in-situ. The major obstacle that we had faced during the project is the absence of stable and efficient expression vectors in probiotics. Most of the project period was invested to screen and isolate strong promoter to express high amounts of the detoxify enzyme on one hand and to stabilize the expression vector on the other hand. In order to estimate the detoxification capacity of the isolated promoters we had developed two very sensitive bioassays.The first system was based on Saccharomyces cerevisiae cells expressing the green fluorescent protein (GFP). Human liver cells proliferation was used as the second bioassay system.Using both systems we were able to prove actual detoxification on living cells by probiotic bacteria expressing Tri101. The first step was the isolation of already discovered strong promoters from lactic acid bacteria, cloning them downstream the Tri101 gene and transformed vectors to E. coli, a lactic acid bacteria strain Lactococcuslactis MG1363, and a probiotic strain of Lactobacillus casei. All plasmid constructs transformed to L. casei were unstable. The promoter designated lacA found to be the most efficient in reducing T-2 from the growth media of E. coli and L. lactis. A prompter library was generated from L. casei in order to isolate authentic probiotic promoters. Seven promoters were isolated, cloned downstream Tri101, transformed to bacteria and their detoxification capability was compared. One of those prompters, designated P201 showed a relatively high efficiency in detoxification. Sequence analysis of the promoter region of P201 and another promoter, P41, revealed the consensus region recognized by the sigma factor. We further attempted to isolate an inducible, strong promoter by comparing the protein profiles of L. casei grown in the presence of 0.3% bile salt (mimicking intestine conditions). Six spots that were consistently overexpressed in the presence of bile salts were isolated and identified. Their promoter reigns are now under investigation and characterization.
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Davide Povero, Davide Povero. You have mail: Stem Cell messages for fighting liver diseases. Experiment, luty 2015. http://dx.doi.org/10.18258/4719.

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Zhou, Ting, Roni Shapira, Peter Pauls, Nachman Paster i Mark Pines. Biological Detoxification of the Mycotoxin Deoxynivalenol (DON) to Improve Safety of Animal Feed and Food. United States Department of Agriculture, lipiec 2010. http://dx.doi.org/10.32747/2010.7613885.bard.

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The trichothecene deoxynivalenol (DON, vomitoxin), one of the most common mycotoxin contaminants of grains, is produced by members of the Fusarium genus. DON poses a health risk to consumers and impairs livestock performance because it causes feed refusal, nausea, vomiting, diarrhea, hemolytic effects and cellular injury. The occurrence of trichothecenes contamination is global and they are very resistant to physical or chemical detoxification techniques. Trichothecenes are absorbed in the small intestine into the blood stream. The overall objective of this project was to develop a protecting system using probiotic bacteria that will express trichothecene 3-O-acetyltransferase (Tri101) that convert T-2 to a less toxic intermediate to reduce ingested levels in-situ. The major obstacle that we had faced during the project is the absence of stable and efficient expression vectors in probiotics. Most of the project period was invested to screen and isolate strong promoter to express high amounts of the detoxify enzyme on one hand and to stabilize the expression vector on the other hand. In order to estimate the detoxification capacity of the isolated promoters we had developed two very sensitive bioassays.The first system was based on Saccharomyces cerevisiae cells expressing the green fluorescent protein (GFP). Human liver cells proliferation was used as the second bioassay system.Using both systems we were able to prove actual detoxification on living cells by probiotic bacteria expressing Tri101. The first step was the isolation of already discovered strong promoters from lactic acid bacteria, cloning them downstream the Tri101 gene and transformed vectors to E. coli, a lactic acid bacteria strain Lactococcuslactis MG1363, and a probiotic strain of Lactobacillus casei. All plasmid constructs transformed to L. casei were unstable. The promoter designated lacA found to be the most efficient in reducing T-2 from the growth media of E. coli and L. lactis. A prompter library was generated from L. casei in order to isolate authentic probiotic promoters. Seven promoters were isolated, cloned downstream Tri101, transformed to bacteria and their detoxification capability was compared. One of those prompters, designated P201 showed a relatively high efficiency in detoxification. Sequence analysis of the promoter region of P201 and another promoter, P41, revealed the consensus region recognized by the sigma factor. We further attempted to isolate an inducible, strong promoter by comparing the protein profiles of L. casei grown in the presence of 0.3% bile salt (mimicking intestine conditions). Six spots that were consistently overexpressed in the presence of bile salts were isolated and identified. Their promoter reigns are now under investigation and characterization.
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Condeelis, John. Isolation of Motile Tumor Cells From Live Breast Tumors. Fort Belvoir, VA: Defense Technical Information Center, czerwiec 2001. http://dx.doi.org/10.21236/ada395259.

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Condeelis, John. Isolation of Motile Tumor Cells from Live Breast Tumors. Fort Belvoir, VA: Defense Technical Information Center, czerwiec 2002. http://dx.doi.org/10.21236/ada412991.

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Audet, René, i Tom Lebrun. Livre blanc : L'intelligence artificielle et le monde du livre. Observatoire international sur les impacts sociétaux de l’intelligence artificielle et du numérique, wrzesień 2020. http://dx.doi.org/10.61737/zhxd1856.

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Québec et Montréal, le 21 septembre 2020 – L’intelligence artificielle (IA) dans le monde du livre est une réalité. En effet, elle n’est pas réservée aux plateformes de vente ou aux applications médicales. L’IA peut assister l’écriture, accompagner le travail éditorial ou encore aider le libraire. Elle peut répondre à des besoins criants ; malgré ses limites évidentes, elle permet d’envisager des applications inédites dans la chaîne du livre, qui font ici l’objet de recommandations précises. Ce livre blanc, rédigé par deux spécialistes du livre et de l’intelligence artificielle, vise à identifier des pistes d’action pour mettre l’IA au service des nombreux maillons du monde du livre. « Dans ce milieu, où doivent être menées les réflexions utiles à la planification de l’avenir immédiat de ce créneau culturel, l’idée d’une concertation de certains de ses acteurs sur l’utilisation d’IA (voire l’éventuelle mise en commun des données collectées) est une piste à suivre. » Cette concertation est appelée par nombre d’experts, qui témoignent dans ce Livre blanc des enjeux propres au contexte culturel actuel menacé par les géants du commerce : « Si l’IA appelle une vigilance constante concernant son utilisation, il paraît important pour les acteurs du monde du livre de rester très attentifs aux avancées technologiques, tant à ce qu’elles pourraient bousculer qu’à ce qu’elles pourraient apporter. » (Virginie Clayssen, Éditis / Commission numérique du Syndicat national de l’édition, France) Ainsi, « la voie dorée pour l’introduction d’IA, pensée comme intelligence augmentée, dans les différents maillons de la chaîne est sans aucun doute celle d’une exploitation des différentes données déjà disponibles ».
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Xiaoliang Sunney Xie. Real-Time Gene Expression Profiling of Live Shewanella Oneidensis Cells. Office of Scientific and Technical Information (OSTI), marzec 2009. http://dx.doi.org/10.2172/950422.

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