Artykuły w czasopismach: „Li-Chin”

1

Chu, Chang, Yejie Lin i Shuqiang Li. "New genera and new species of Hahniidae (Araneae) from China, Laos, Myanmar, and Vietnam". ZooKeys 1187 (20.12.2023): 91–134. http://dx.doi.org/10.3897/zookeys.1187.112936.

Pełny tekst źródła

Streszczenie:

Four new genera and 11 new species of Hahniidae Bertkau, 1878 are described. The new genera are Goblinia Lin & Li, gen. nov., with the type species G. tiane Lin & Li, sp. nov. (♂♀) from Guangxi, China; Myahnia Lin & Li, gen. nov., with the type species M. kanpetlet Lin & Li, sp. nov. (♂♀) from Chin, Myanmar; Troglohnia Lin & Li, gen. nov., with the type species Tr. qiubei Lin & Li, sp. nov. (♂♀) from Yunnan, China and Typhlohnia Lin & Li, gen. nov., with the type species Ty. rongshui Lin & Li, sp. nov. (♂♀) from Guangxi, China. Seven additional new species are described: Tr. dafang Lin & Li, sp. nov. (♂♀) from Guizhou, China; Tr. shidian Lin & Li, sp. nov. (♀) from Yunnan, China; Tr. wuding Lin & Li, sp. nov. (♂♀) from Yunnan, China; Ty. banlaksao Lin & Li, sp. nov. (♀) from Bolikhamxay, Laos; Ty. kaiyang Lin & Li, sp. nov. (♀) from Guizhou, China; Ty. sondoong Lin & Li, sp. nov. (♂♀) from Quang Binh, Vietnam and Ty. suiyang Lin & Li, sp. nov. (♀) from Guizhou, China.

Style APA, Harvard, Vancouver, ISO itp.

2

Smith, Wendy. "Reviewer Acknowledgements for International Journal of Statistics and Probability, Vol. 3, No. 4". International Journal of Statistics and Probability 3, nr 4 (31.10.2014): 86. http://dx.doi.org/10.5539/ijsp.v3n4p86.

Pełny tekst źródła

Streszczenie:

International Journal of Statistics and Probability wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal is greatly appreciated. Many authors, regardless of whether International Journal of Statistics and Probability publishes their work, appreciate the helpful feedback provided by the reviewers. Reviewers for Volume 3, Number 4 Abdullah A. SMADI Anna Grana' Bibi Abdelouahab Carla J. Thompson Carolyn Huston Chin-Shang Li Ehsan Karim Enayetur Raheem Ivair R. Silva Jacek Bialek Jorge M. Mendes Kouji Yamamoto Lishu Li Michela Ottobre Philip Westgate Sajid Ali Sohair F. Higazi Vyacheslav Abramov Yichuan Zhao Zaixing Li Wendy Smith On behalf of, The Editorial Board of International Journal of Statistics and Probability Canadian Center of Science and Education

Style APA, Harvard, Vancouver, ISO itp.

3

Barrett, T. H. "Towards a date for the Chin-so liu-chu yin". Bulletin of the School of Oriental and African Studies 53, nr 2 (czerwiec 1990): 292–94. http://dx.doi.org/10.1017/s0041977x00026094.

Pełny tekst źródła

Streszczenie:

The Chin-so liu-chu yin is a text of twenty-nine fascicles preserved in the Taoist canon in the form of a revelation to Chang Tao-ling, the late Han founder of the Taoist religion, to which comments by Li Ch‘un-feng (602–670) are attached. Though scholars have not so far addressed the question of the origins of the text itself, a certain willingness to accept the attribution of the commentary has already been made manifest. Yet to the eye of the expert in Sung Taoism this attribution raises serious doubts: text and commentary display features much more reminiscent of Sung religion than that of the early T'ang. It has already been noticed that Li Ch'un-feng provides information on the cult of the city gods (ch'eng-huang shen) and on Thunder magic; the former religious development may be traced back before the T‘ang but only achieved prominence towards the end of the dynasty, while the latter is unattested in T‘ang Taoist literature. One might add that Li displays a detailed knowledge of the legend of Hsü Sun in a developed form—again a cult v with early origins hardly noticed until the late T‘ang. The text also provides information (though separately) on the Buddhist warrior-king Vaisravana (P‘isha-men PI) and on the seventh-century warrior-hero Li Ching (571–649): these two figures were eventually to merge.

Style APA, Harvard, Vancouver, ISO itp.

4

Carmichael, Stephen W., i Nita J. Maihle. "Directly Reading The Genome". Microscopy Today 9, nr 2 (marzec 2001): 3–7. http://dx.doi.org/10.1017/s1551929500056388.

Pełny tekst źródła

Streszczenie:

The code for the human genome is essentially complete, opening an expansive book about our biologic composition. But the problem is to read this book. The font size is very small, What you are reading now is 9 point font, and genetic information would correspond to approximately 10-50 point font, six orders of magnitude smaller. There are methods to derive genetic information, but recently Adam Woolley, Chantal Guillemette, Chin-Li Cheung, David Housman, and Charles Lieber have developed an elegant way to directly read genetic information with a microscope. The microscope they used was an atomic force microscope (AFM) that employed a single-walled carbon nanotube as its probe.

Style APA, Harvard, Vancouver, ISO itp.

5

Slowik, M. "Beyond Lot's Wife: The Immigration Poems of Marilyn Chin, Garrett Hongo, Li-Young Lee, and David Mura". MELUS: Multi-Ethnic Literature of the United States 25, nr 3-4 (1.09.2000): 221–42. http://dx.doi.org/10.2307/468244.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

6

Jones, Arlene. "Eurytrema cladorchis Chin, Li & Wei, 1965 (Trematoda: Dicrocoeliidae), a little known species from China and Nepal". Systematic Parasitology 7, nr 1 (kwiecień 1985): 43–45. http://dx.doi.org/10.1007/bf00010160.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

7

Musielak, Janina. "Procesy restrukturyzacji w przemyśle okrętowym (na przykładzie Stoczni Szczecińskiej S.A.)". Studies of the Industrial Geography Commission of the Polish Geographical Society 3 (1.01.2002): 155–66. http://dx.doi.org/10.24917/20801653.3.14.

Pełny tekst źródła

Streszczenie:

Historia budownictwa okrętowego w Szczecinie sięga kilkuset lat, jednak najbardziej dynamiczny okres rozwoju tego sektora przemysłu rozpoczął się od połowy XIX wieku. Najstarszą szczecińską stocznią była stocznia M. Nuscke'go jednakże najważniejszą rolę odegrała stocznia Vulcan, pierwsza niemiecka stocznia budująca okręty ze stali. Przełomowym był rok 1866, kiedy to przekazano do eksploatacji pierwszy okręt wojenny. Z czasem stocznia Vulcan dostarczała także statki pasażerskie dla armatorów z Hamburga i Bremy oraz statki i okręty dla Rosji, Japonii, Chin i Grecji. Dobra koniunktura w przemyśle okrętowym Szczecina trwała do końca 1926 roku, kiedy to na skutek kryzysu i konkurencji innych stoczni niemieckich praktycznie zaprzestano produkcji. a stocznia uległa stopniowej likwidacji. Częściowo wznowione procesy budowy okrętów podwodnych pod koniec li wojny światowej nie przywróciły stoczni jej pozycji.

Style APA, Harvard, Vancouver, ISO itp.

8

Postelnicu, T. "Li, Chung Chin: Analysis of unbalanced data: a pre-program introduction. Cambridge University Press 1982, 165 pp., £ 12.95". Biometrical Journal 28, nr 3 (1986): 384. http://dx.doi.org/10.1002/bimj.4710280318.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

9

Kuhn, Ninoslava Šarac, i Ronnie B. Wilbur. "Interrogative structures in Croatian Sign Language: Polar and content questions". Sign Language and Linguistics 9, nr 1-2 (2006): 151–67. http://dx.doi.org/10.1075/sll.9.1-2.09kuh.

Pełny tekst źródła

Streszczenie:

In this study, we investigate the interrogative structures in Croatian Sign Language (HZJ) with respect to the word order, manual question words, and nonmanual markers and their scope. Both polar and content questions mainly use specific nonmanual markers to indicate interrogative function. Polar questions use chin down and content questions use chin up as their prominent nonmanual markers. In addition to these markers, brows up occurs in both constructions leading to the suggestion that brows up may be a general question marker in HZJ. Brows down can also occur, particularly in content questions. Other nonmanual markers that appear in polar questions are head forward, and eyes wide open and those in content questions are head forward, headshake, shoulders up, and eyes closed.Both interrogative constructions use manual question words. Polar questions can use an optional manual sign je-li that was probably introduced to HZJ through Signed Croatian. je-li is not connected to the peak intensity of the nonmanual markers and we consider it to be an adjunct to the question structure. Content words are used in most HZJ content interrogatives. Question words can be represented by specific signs or can be formed by the content sign ‘5’ (i.e. handshape 5 or b-th moving side-to-side). This ‘5’ sign is further specified by mouthing the particular question word from spoken Croatian. Content words can appear in sentence initial, sentence final or both positions. In content questions, question words bear the highest peak of nonmanual intensity, thus we consider them to be operating as operators.Recent research shows that HZJ shares some features with Austrian Sign Language (ÖGS) because in the 19th century, Croatian deaf students attended Vienna’s Institute for the Deaf (Schalber this volume; Šarac 2003; Šarac et al in press). Upon finishing their education, they would return back to Croatia. Similarities between HZJ and ÖGS are found in their interrogative nonmanual markings but not in their syntactic structures. This can be seen by the fact that these two sign languages do not have the same canonical word order.

Style APA, Harvard, Vancouver, ISO itp.

10

Kuhn, Ninoslava Šarac, i Ronnie B. Wilbur. "Interrogative structures in Croatian Sign Language". Investigating Understudied Sign Languages - Croatian SL and Austrian SL, with comparison to American SL 9, nr 1-2 (31.12.2006): 151–67. http://dx.doi.org/10.1075/sll.9.1.09kuh.

Pełny tekst źródła

Streszczenie:

In this study, we investigate the interrogative structures in Croatian Sign Language (HZJ) with respect to the word order, manual question words, and nonmanual markers and their scope. Both polar and content questions mainly use specific nonmanual markers to indicate interrogative function. Polar questions use chin down and content questions use chin up as their prominent nonmanual markers. In addition to these markers, brows up occurs in both constructions leading to the suggestion that brows up may be a general question marker in HZJ. Brows down can also occur, particularly in content questions. Other nonmanual markers that appear in polar questions are head forward, and eyes wide open and those in content questions are head forward, headshake, shoulders up, and eyes closed. Both interrogative constructions use manual question words. Polar questions can use an optional manual sign je-li that was probably introduced to HZJ through Signed Croatian. je-li is not connected to the peak intensity of the nonmanual markers and we consider it to be an adjunct to the question structure. Content words are used in most HZJ content interrogatives. Question words can be represented by specific signs or can be formed by the content sign ‘5’ (i.e. handshape 5 or b-th moving side-to-side). This ‘5’ sign is further specified by mouthing the particular question word from spoken Croatian. Content words can appear in sentence initial, sentence final or both positions. In content questions, question words bear the highest peak of nonmanual intensity, thus we consider them to be operating as operators. Recent research shows that HZJ shares some features with Austrian Sign Language (ÖGS) because in the 19th century, Croatian deaf students attended Vienna’s Institute for the Deaf (Schalber this volume; Šarac 2003; Šarac et al in press). Upon finishing their education, they would return back to Croatia. Similarities between HZJ and ÖGS are found in their interrogative nonmanual markings but not in their syntactic structures. This can be seen by the fact that these two sign languages do not have the same canonical word order.

Style APA, Harvard, Vancouver, ISO itp.

11

WU, Peichen. "Traveling Japan, Writing Japan：The Translation and Publishing of the Travelogue Wareteki Nihon". Border Crossings: The Journal of Japanese-Language Literature Studies 13, nr 1 (30.12.2021): 53–60. http://dx.doi.org/10.22628/bcjjl.2021.13.1.53.

Pełny tekst źródła

Streszczenie:

The travelogue Wareteki Nihon was published in December 2018 by Hakushui Sha, and included the work of eighteen Taiwanese writers from various generations. All their works in the text relate to their travels in Japan. These Taiwanese writers are Kan Yao-Ming, Ko Yu-fen, Huang Li-Chun, Wang Sheng-Hong, Jiang E, Chen Bo-Chin, Hu Mu-Ching, Sheng Hao-We, Chu He-Chih, Wu Ming-Yi, Lu Hui-Hsin, Yi Ge-Yan, Yen Shu-Hsia, and Liu Shu-Hui, whose works in this anthology depict Japanese scenery, culture and literature, and so on. This paper will focus on how this publishing project started, the process of producing this travelogue, and the evaluations and responses of Japan’s literary circle and the mass media to it after its publication in Japan.

Style APA, Harvard, Vancouver, ISO itp.

12

Adnan, Nasira, Erum Amin, Ramsha Nawaz, Muska Ijaz, Tooba Ishtiaq Shah i Tehreem Janjua. "Cephalometric Differences In Male And Female Characteristics of Facial Soft Tissue Thickness In Various Orthodontic Malocclusions". Pakistan Armed Forces Medical Journal 74, nr 2 (29.04.2024): 410–14. http://dx.doi.org/10.51253/pafmj.v74i2.8422.

Pełny tekst źródła

Streszczenie:

Objective: To compare the mean facial soft tissue thickness between males and females in different malocclusion groups. Study Design: Cross-Sectional Study. Place and Duration of Study: Armed Forces Institute of Dentistry, Rawalpindi Pakistan, from Jan 2020 to Jan 2021. Methodology: Cephalometric radiographs of 230 patients were used to measure soft tissue thickness at seven landmarks: the glabella, subnasal region, labrale superius, labrale inferius, sulcus labrale superius, labiomentalis, and soft tissue chin. Results: Of 230 patients, 39% were of Class I, 21% of Class II/1, 26% of Class II/2 and 13% of Class III. The gender ratio was the same in all skeletal classes. The mean age of 230 patients was 18.36±2.29 years. The mean ANB angle and UI were 4.02±3.22 and 25.95±8.86. The mean ANB angle and UI significantly differed between skeletal classes. In contrast, the mean age of patients of different skeletal classes was not significantly different, with a p-value of 0.433. The mean FSTT measured from subnasal area (A-NS), sulcus labrale superius (RR-SLS), labrale superius (J-LS), labrale inferius (I-Li) and chin (Pg-Pg1) was significantly different between skeletal classes (p value <0.001). Conclusion: The facial soft tissue thickness was thicker in class III. The FST measured through the labrale superius (J-LS) of male patients was thicker than that of female patients in all skeletal class patients.

Style APA, Harvard, Vancouver, ISO itp.

13

Gonzalez-Carrillo, Gabino, Roberto Muñiz-Valencia, Efren V. García-Báez i Francisco J. Martínez-Martínez. "Crystal structure of a new polymorph of 3-acetyl-8-methoxy-2H-chromen-2-one". Acta Crystallographica Section E Crystallographic Communications 75, nr 12 (15.11.2019): 1866–70. http://dx.doi.org/10.1107/s2056989019015159.

Pełny tekst źródła

Streszczenie:

A new polymorphic form of the title compound, C12H10O4, is described in the orthorhombic space group Pbca and Z = 8, as compared to polymorph I, which crystallizes in the monoclinic space group C2/c and Z = 8 [Li et al. (2012). Chin. J. Struct. Chem. 31, 1003–1007.]. In polymorph II, the coumarin ring system is almost planar (r.m.s. deviation = 0.00129 Å). In the crystal, molecules are connected by Csp 3—H...O and Car—H...O hydrogen bonds, forming molecular sheets linked into zigzag shaped layers along the b-axis direction. The three-dimensional lattice is assembled through stacking of the zigzag layers by π–π interactions with a centroid-to-centroid distance of 3.600 (9) Å and antiparallel C=O...C=O interactions with a distance of 3.1986 (17) Å, which give rise to a helical supramolecular architecture.

Style APA, Harvard, Vancouver, ISO itp.

14

Niu, Y. B., L. Qing, M. Yao, D. F. Wang, J. D. Liu i J. S. Wang. "First Report of Tobacco mosaic virus in Abutilon theophrasti in China". Plant Disease 93, nr 11 (listopad 2009): 1221. http://dx.doi.org/10.1094/pdis-93-11-1221b.

Pełny tekst źródła

Streszczenie:

Velvetleaf (Abutilon theophrasti Medic), a tall, fecund, self-fertile annual plant in the family Malvaceae, is widely grown in China as a fiber crop and for its medicinal properties. In July of 2008, we observed diffuse chlorotic and necrotic spots on the oldest leaves of velvetleaf plants in the field in Shanxi Province. Sap extracts from six symptomatic plants were tested by direct antigen coated ELISA using polyclonal antibodies specific to Potato virus Y (PVY) and monoclonal antibodies specific to Tomato mosaic virus (ToMV), Cucumber mosaic virus (CMV), and Tobacco mosaic virus (TMV). Five of the six samples were negative for ToMV, CMV, and PVY but positive for TMV. Double-stranded RNA extracted from leaves of the five velvetleaf plants was used as template for reverse transcription (RT)-PCR as described by Krajačića et al. (1) and Li et al. (2) with some modifications. One-step RT-PCR was performed using a Quant One Step RT-PCR Kit (TIANGEN BIOTECH CO., LTD., Beijing, China) with sense (5′-CTGTTTAGCCGGTTTGGT-3′), and antisense (5′-TCCCTTTACGGACATCAC-3′) primers (3) designed to specifically amplify a fragment of the movement protein coding region of TMV. The expected 470-bp fragments were amplified from dsRNA from these five plants and the amplicon from each plant was cloned and sequenced (GenBank Accession No. FJ873800). Comparisons of a consensus sequence derived from the five amplicons with the nucleotide sequences available in the NCBI database using BLAST showed 99% identity with TMV from South Korea (GenBank Accession No. AB354955) and Spain (Accession No. AJ308692) and 98% with TMV from China (Accession No. AF165190). The serological, RT-PCR results and sequence data revealed that these velvetleaf plants were infected by TMV. On the basis of the serological analysis and genome sequence comparisons, this isolate was tentatively designated as TMV-Velvetleaf. To our knowledge, this is the first report of TMV in Abutilon theophrasti Medic in China. References: (1) M. Krajačić et al. J. Chromatogr A. 1144:111, 2007. (2) H. Li et al. Agric. Sci. Chin. 6:86, 2007. (3) Y. B. Niu et al. Chin. Biotechnol. 29:76, 2009.

Style APA, Harvard, Vancouver, ISO itp.

15

Smith, Wendy. "Reviewer Acknowledgements". International Journal of Statistics and Probability 8, nr 2 (28.02.2019): 192. http://dx.doi.org/10.5539/ijsp.v8n2p192.

Pełny tekst źródła

Streszczenie:

International Journal of Statistics and Probability wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal is greatly appreciated. Many authors, regardless of whether International Journal of Statistics and Probability publishes their work, appreciate the helpful feedback provided by the reviewers. Reviewers for Volume 8, Number 2 Abdullah A. Smadi, Yarmouk University, Jordan Afsin Sahin, Gazi University, Turkey Carla J. Thompson, University of West Florida, USA Chin-Shang Li, School of Nursing, USA Gabriel A. Okyere, Kwame Nkrumah University of Science and Technology, Ghana Hui Zhang, St. Jude Children’s Research Hospital, USA Nahid Sanjari Farsipour, Alzahra University, Iran Philip Westgate, University of Kentucky, USA Sajid Ali, Quaid-i-Azam University, Pakistan Shatrunjai Pratap Singh, John Hancock Financial Services, USA Wei Zhang, The George Washington University, USA Weizhong Tian, Eastern New Mexico University, USA Wojciech Gamrot, University of Economics, Poland Zaixing Li, China University of Mining and Technology (Beijing), China   Wendy Smith On behalf of, The Editorial Board of International Journal of Statistics and Probability Canadian Center of Science and Education

Style APA, Harvard, Vancouver, ISO itp.

16

Smith, Wendy. "Reviewer Acknowledgements for International Journal of Statistics and Probability, Vol. 9, No. 1". International Journal of Statistics and Probability 9, nr 1 (3.01.2020): 87. http://dx.doi.org/10.5539/ijsp.v9n1p87.

Pełny tekst źródła

Streszczenie:

International Journal of Statistics and Probability wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal is greatly appreciated. Many authors, regardless of whether International Journal of Statistics and Probability publishes their work, appreciate the helpful feedback provided by the reviewers. Reviewers for Volume 9, Number 1   Chin-Shang Li, School of Nursing, USA Faisal Khamis, Al Ain University of Science and Technology, Canada Felix Almendra-Arao, UPIITA del Instituto Politécnico Nacional, México Gabriel A. Okyere, Kwame Nkrumah University of Science and Technology, Ghana Gerardo Febres, Universidad Simón Bolívar, Venezuela Mohieddine Rahmouni, University of Tunis, Tunisia Noha Youssef, American University in Cairo, Egypt Philip Westgate, University of Kentucky, USA Qingyang Zhang, University of Arkansas, USA Shatrunjai Pratap Singh, John Hancock Financial Services, USA Weizhong Tian, Eastern New Mexico University, USA Zaixing Li, China University of Mining and Technology (Beijing), China   Wendy Smith On behalf of, The Editorial Board of International Journal of Statistics and Probability Canadian Center of Science and Education

Style APA, Harvard, Vancouver, ISO itp.

17

Pattanaik, Snigdha, i Sudhakar Pathuri. "Establishment of Aesthetic Soft Tissue Norms for Southern India Population: A Photogrammetric Study". Orthodontic Journal of Nepal 4, nr 1 (24.10.2014): 29–35. http://dx.doi.org/10.3126/ojn.v4i1.11308.

Pełny tekst źródła

Streszczenie:

Objective: To establish soft tissue facial profile norms for Coastal Andhra population by means of angular measurements and toevaluate the difference between male & female groups.Materials & Method: 90 individuals (45 males, 45 females) of age group 18-25 years of native coastal Andhra Pradesh, withacceptable pleasing profile, normal Class I occlusion having ideal anterior bite were selected for the study. Standard profilephotographs were taken and angular photogrammetric analysis was carried out through AutoCAD software.Result: There were significant difference in Naso-frontal angle (G–N–Nd; males: 130.64 ± 6.27o; females: 140.33o ± 6.85o; P = 0.000)and Mento-labial angle (Li–Sm–Pg: females: 127.38o ± 5.35o; males: 124.82o ± 6.57o; P = 0.043).Conclusion: The males of Coastal Andhra Pradesh have mild convex profile and prominent nose whereas females have mildconvex profile due to recessive chin. A higher upper lip prominence was seen in males.DOI: http://dx.doi.org/10.3126/ojn.v4i1.11308 Orthodontic Journal of Nepal Vol.4(1) 2014; 29-35

Style APA, Harvard, Vancouver, ISO itp.

18

Bussadori, Sandra Kalil, Carlos Eduardo Bugano de Oliveira, Carolina Cardoso Guedes, Kristianne Porta Fernandes, Analúcia Ferreira Marangoni, Maria Aldeíde Costa Borges i Elaine Marcílio Santos. "Patients with Class II Malocclusion: Cephalometric analysis in the Tegumentary Profile". ConScientiae Saúde 8, nr 3 (29.10.2009): 497–502. http://dx.doi.org/10.5585/conssaude.v8i3.1641.

Pełny tekst źródła

Streszczenie:

The aim of the study was to assess cephalometric abnormalities in the tegumentary profile of patients with Class II malocclusion. Twenty patients with average age of seven years and eight months were divided into: Group I - control, Class I, no malocclusions (n=10); Group II – Class II malocclusion (n=10). Standardized radiography was performed for the obtainment of the cephalometric points. Langlade’s classification was employed and the features were used: GN.Sn.Pog, ANL,A´-Gv, Pog´- Gv, Ls-GV, Li-GV, Sls-Gv, Sli-Gv. The Student’s t-test and Pearson’s correlation were used, with the level of significance set at 5%. The results show that the patients with Class II had more convex tegumentary profile, less protruded mid face and upper lip, less depth of the upper lip groove and more retracted lower lip and tegumentary chin, with statistically significant differences between groups (p0.005). The conclusion is that the patients with Class II malocclusion exhibited cephalometric abnormalities in the tegumentary profile.

Style APA, Harvard, Vancouver, ISO itp.

19

Jurkiewicz, Marcin. "Bounds on isolated scattering number". ANZIAM Journal 62 (27.11.2021): C72—C83. http://dx.doi.org/10.21914/anziamj.v62.15912.

Pełny tekst źródła

Streszczenie:

The isolated scattering number is a parameter that measures the vulnerability of networks. This measure is bounded by formulas depending on the independence number. We present new bounds on the isolated scattering number that can be calculated in polynomial time. References Z. Chen, M. Dehmer, F. Emmert-Streib, and Y. Shi. Modern and interdisciplinary problems in network science: A translational research perspective. CRC Press, 2018. doi: 10.1201/9781351237307 P. Erdős and T. Gallai. On the minimal number of vertices representing the edges of a graph. Magyar Tud. Akad. Mat. Kutató Int. Közl. 6 (1961), pp. 181–203. url: http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.210.7468 J. Harant and I. Schiermeyer. On the independence number of a graph in terms of order and size. Discrete Math. 232.1–3 (2001), pp. 131–138. doi: 10.1016/S0012-365X(00)00298-3 E. Korach, T. Nguyen, and B. Peis. Subgraph characterization of red/blue-split graph and Kőnig Egerváry graphs. Proceedings of the Seventeenth Annual ACM-SIAM Symposium on Discrete Algorithms. ACM, New York, 2006, pp. 842–850. doi: 10.1145/1109557.1109650 F. Li, Q. Ye, and Y. Sun. Proceedings of the 2016 Joint Conference of ANZIAM and Zhejiang Provincial Applied Mathematics Association, ANZPAMS-2016. Ed. by P. Broadbridge, M. Nelson, D. Wang, and A. J. Roberts. Vol. 58. ANZIAM J. 2017, E81–E97. doi: 10.21914/anziamj.v58i0.10993 F. Li, Q. Ye, and X. Zhang. Isolated scattering number of split graphs and graph products. ANZIAM J. 58.3-4 (2017), pp. 350–358. doi: 10.1017/S1446181117000062 E. R. Scheinerman and D. H. Ullman. Fractional graph theory. Dover Publications, 2011. url: https://www.ams.jhu.edu/ers/wp-content/uploads/2015/12/fgt.pdf S. Y. Wang, Y. X. Yang, S. W. Lin, J. Li, and Z. M. Hu. The isolated scattering number of graphs. Acta Math. Sinica (Chin. Ser.) 54.5 (2011), pp. 861–874. url: http://www.actamath.com/EN/abstract/abstract21097.shtml M. Xiao and H. Nagamochi. Exact algorithms for maximum independent set. Inform. and Comput. 255, Part 1 (2017), pp. 126–146. doi: 10.1016/j.ic.2017.06.001

Style APA, Harvard, Vancouver, ISO itp.

20

Smith, Wendy. "Reviewer Acknowledgements for International Journal of Statistics and Probability, Vol. 8, No. 5". International Journal of Statistics and Probability 8, nr 5 (30.08.2019): 103. http://dx.doi.org/10.5539/ijsp.v8n5p103.

Pełny tekst źródła

Streszczenie:

International Journal of Statistics and Probability wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal is greatly appreciated. Many authors, regardless of whether International Journal of Statistics and Probability publishes their work, appreciate the helpful feedback provided by the reviewers. Reviewers for Volume 8, Number 5 Abdullah A. Smadi, Yarmouk University, Jordan Carla J. Thompson, University of West Florida, USA Chin-Shang Li, School of Nursing, USA Encarnación Alvarez-Verdejo, University of Granada, Spain Felix Almendra-Arao, UPIITA del Instituto Politécnico Nacional , México Gabriel A. Okyere, Kwame Nkrumah University of Science and Technology, Ghana Gane Samb Lo, University Gaston Berger, SENEGAL Gennaro Punzo, University of Naples Parthenope, Italy Gerardo Febres, Universidad Simón Bolívar, Venezuela Ivair R. Silva, Federal University of Ouro Preto – UFOP, Brazil Mingao Yuan, North Dakota State University, USA Philip Westgate, University of Kentucky, USA Qingyang Zhang, University of Arkansas, USA Sajid Ali, Quaid-i-Azam University, Pakistan Sohair F. Higazi, University of Tanta, Egypt Subhradev Sen, Alliance University, India Vyacheslav Abramov, Swinburne University of Technology, Australia Wei Zhang, The George Washington University, USA Yuvraj Sunecher, University of Technology Mauritius, Mauritius Zaixing Li, China University of Mining and Technology (Beijing), China   Wendy Smith On behalf of, The Editorial Board of International Journal of Statistics and Probability Canadian Center of Science and Education

Style APA, Harvard, Vancouver, ISO itp.

21

Smith, Wendy. "Reviewer Acknowledgements for International Journal of Statistics and Probability, Vol. 8, No. 5". International Journal of Statistics and Probability 8, nr 5 (30.08.2019): 83. http://dx.doi.org/10.5539/ijsp.v8n5p83.

Pełny tekst źródła

Streszczenie:

International Journal of Statistics and Probability wishes to acknowledge the following individuals for their assistance with peer review of manuscripts for this issue. Their help and contributions in maintaining the quality of the journal is greatly appreciated. Many authors, regardless of whether International Journal of Statistics and Probability publishes their work, appreciate the helpful feedback provided by the reviewers. Reviewers for Volume 8, Number 5 Abdullah A. Smadi, Yarmouk University, Jordan Carla J. Thompson, University of West Florida, USA Chin-Shang Li, School of Nursing, USA Encarnación Alvarez-Verdejo, University of Granada, Spain Felix Almendra-Arao, UPIITA del Instituto Politécnico Nacional , México Gabriel A. Okyere, Kwame Nkrumah University of Science and Technology, Ghana Gane Samb Lo, University Gaston Berger, SENEGAL Gennaro Punzo, University of Naples Parthenope, Italy Gerardo Febres, Universidad Simón Bolívar, Venezuela Ivair R. Silva, Federal University of Ouro Preto – UFOP, Brazil Mingao Yuan, North Dakota State University, USA Philip Westgate, University of Kentucky, USA Qingyang Zhang, University of Arkansas, USA Sajid Ali, Quaid-i-Azam University, Pakistan Sohair F. Higazi, University of Tanta, Egypt Subhradev Sen, Alliance University, India Vyacheslav Abramov, Swinburne University of Technology, Australia Wei Zhang, The George Washington University, USA Yuvraj Sunecher, University of Technology Mauritius, Mauritius Zaixing Li, China University of Mining and Technology (Beijing), China   Wendy Smith On behalf of, The Editorial Board of International Journal of Statistics and Probability Canadian Center of Science and Education

Style APA, Harvard, Vancouver, ISO itp.

22

Boo-Chai, Khoo. "Li Chang-lian et al. An analysis of serum free amino acid profiles in severely burned patients. (Chinese) Chin. J. Plast. Surg. Burns 6". Plastic and Reconstructive Surgery 89, nr 5 (maj 1992): 1007. http://dx.doi.org/10.1097/00006534-199205000-00084.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

23

Schwartz, Stanley, i Marilyn E. Miller. "Atlas of Cytochemistry and Immunochemistry of Hematologic Neoplasms Tsieh Sun, Chin-Yang Li, Lung T. Yam American Society of Clinical Pathologists Press Chicago, IL". International Journal of Cell Cloning 4, nr 3 (1986): 221. http://dx.doi.org/10.1002/stem.5530040307.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

24

Akter, Lubna, i Md Zakir Hossain. "Angular Photogrammetric Soft Tissue Facial Profile Analysis of Bangladeshi Young Adults". APOS Trends in Orthodontics 7 (1.12.2017): 279–86. http://dx.doi.org/10.4103/2321-1407.219434.

Pełny tekst źródła

Streszczenie:

Introduction Angular photogrammetric soft tissue facial profile analysis provides a permanent record for the actual appearance of a person, which would also serve to establish an ideal esthetic treatment goal. The aim of the present study was to evaluate the average angular variables that define the soft tissue facial profile of a Bangladeshi sample. Materials and Methods This cross-sectional study was carried out at Department of Orthodontics and Dentofacial Orthopedics of Dhaka Dental College and Hospital, Bangladesh, from July to December 2015. Soft tissue facial profiles of 200 participants (100 males and 100 females) between 18 and 25 years of age, with a dental Class I occlusal relationship and harmonious soft tissue profile, were selected by convenience sampling among students, doctors, and patients of Dhaka Dental College. Standardized photographs of 200 samples were taken in the natural head position. The photographic records were analyzed with the software for Windows, Microsoft Visio 2007, Standard Edition. All data were analyzed through standard methods using Statistical Package for the Statistical Package for Social Science Software (SPSS Version-20, IBM Corp, USA). Results The average angular measurements for nasofrontal, total facial angle, facial angle, upper lip angle, projection of lower lip to chin, and mentolabial angle were wider in females. The mean value for nose tip angle, nasolabial angle, nasomental angle, and projection of upper lip to chin angle was higher in males compared to females. Nasofrontal angle (G-N-Nd) (P = 0.000) and mentolabial angle (Li-Sm-Pg) (P = 0.001) showed statistically significant differences. The greatest variability was found for mentolabial angle. Conclusion The study of angular photogrammetric soft tissue facial profile analysis of Bangladeshi young adults contributes to the establishment of standardized normal values for the population. This study provides data which can be used in treatment planning by specialists such as orthodontists, prosthodontists, plastic surgeons, and maxillofacial surgeons, who have the capability to change the soft tissue facial features.

Style APA, Harvard, Vancouver, ISO itp.

25

Martinez, Victor, Nis Fisker-Bødker, Smobin Vincent i Jin Hyun Chang. "Design of High-Entropy Electrolytes Enabled By the High-Throughput and Autonomous Procedure". ECS Meeting Abstracts MA2023-02, nr 2 (22.12.2023): 375. http://dx.doi.org/10.1149/ma2023-022375mtgabs.

Pełny tekst źródła

Streszczenie:

Electrolytes in Li-ion batteries play a significant role as they influence different aspects directly related to the battery performance, such as safety, voltage window, electrochemical stability, and the formation of solid-electrolyte interphase (SEI). Conventionally, these electrolytes are composed of a lithium salt dissolved in an organic solvent such as ethylene carbonate and propylene carbonate. Regarding safety, these organic electrolytes can be replaced by room-temperature ionic liquids (RTILs), which present lower vapor pressure and non-flammability.1 Moreover, adding polymer to these liquid electrolytes to form polymer gel electrolytes has proven to be a good strategy to avoid dendritic growth and increase electrolyte stability.2 The properties of RTIL electrolytes containing Li salts have been studied in the last decade. Still, the scope has been limited primarily to simple RTILs consisting of one cationic and one anionic species. Inspired by the success of high-entropy alloys (HEAs) for forming stable solid solutions with excellent mechanical properties,3 the concept of high-entropy materials has been recently transferred to electrolytes, where the effect of mixing multiple Li salts is explored.4 However, the number of compositional combinations increases rapidly when multiple salts, cationic and anionic species are introduced, and the explorable compositional space increases even more when polymers are added to the mixture. Automating the electrolyte preparation and characterization can be the key feature to allow the exploration of all the possible electrolyte combinations. In this work, we explain the first preliminary results obtained from an autonomous preparation and characterization of high-entropy electrolytes composed of a mixture of two different lithium salts in ionic liquids consisting of multiple anionic and cationic species. In addition, the adaptation of the autonomous system of preparation and characterization of liquid electrolytes to polymer gel electrolytes is also proposed and explained. References. (1) Niu, H.; Wang, L.; Guan, P.; Zhang, N.; Yan, C.; Ding, M.; Guo, X.; Huang, T.; Hu, X. Recent Advances in Application of Ionic Liquids in Electrolyte of Lithium Ion Batteries. J. Energy Storage 2021, 40, 102659. https://doi.org/10.1016/j.est.2021.102659. (2) Chen, J.; Wu, J.; Wang, X.; Zhou, A.; Yang, Z. Research Progress and Application Prospect of Solid-State Electrolytes in Commercial Lithium-Ion Power Batteries. Energy Storage Mater. 2021, 35, 70–87. https://doi.org/10.1016/j.ensm.2020.11.017. (3) Yeh, J.-W.; Chen, S.-K.; Lin, S.-J.; Gan, J.-Y.; Chin, T.-S.; Shun, T.-T.; Tsau, C.-H.; Chang, S.-Y. Nanostructured High-Entropy Alloys with Multiple Principal Elements: Novel Alloy Design Concepts and Outcomes. Adv. Eng. Mater. 2004, 6 (5), 299–303. https://doi.org/10.1002/adem.200300567. (4) Wang, Q.; Zhao, C.; Wang, J.; Yao, Z.; Wang, S.; Kumar, S. G. H.; Ganapathy, S.; Eustace, S.; Bai, X.; Li, B.; Wagemaker, M. High Entropy Liquid Electrolytes for Lithium Batteries. Nat. Commun. 2023, 14 (1), 440. https://doi.org/10.1038/s41467-023-36075-1.

Style APA, Harvard, Vancouver, ISO itp.

26

Seerab Husain, Navaneethan i Sri Rengalakshmi. "Correlation between gender and soft tissue characteristics of face among south Indian population of various skeletal malocclusion". International Journal of Research in Pharmaceutical Sciences 11, SPL3 (3.12.2020): 1902–10. http://dx.doi.org/10.26452/ijrps.v11ispl3.3633.

Pełny tekst źródła

Streszczenie:

Every face is unique and this variation also exists between genders. This forms the basis of sexual dimorphism. The aim of this study was to determine the correlation between gender and soft tissue of face among the south Indian population. The study sample comprised 30 lateral cephalograms collected between the time period of June 2019 - March 2020, which were divided into 3 groups. FACAD software was used for the analysis of lateral cephalograms to obtain six variables, namely: glabella area (G-G1), subnasal area (A-Sn), Upper lip thickness (J-Ls), Lower lip thickness (I-Li), Labiomental sulcus thickness (B-Sm), Chin area (Pg-Pg1). The obtained results were tabulated and statistically analysed using SPSS software version 23. One-way ANOVA and post hoc tests were performed between the skeletal malocclusions. Independent t-test was done to compare the variables between the two genders. The obtained results show a mean increase in all the variables of Class II except Lower lip thickness, which was maximum in Class I skeletal malocclusion. The results of One-way ANOVA, however, was statistically insignificant. Hence, soft tissue characteristics can provide vital information on sexual dimorphism and also aid in the diagnosis of various malocclusions in orthodontics.

Style APA, Harvard, Vancouver, ISO itp.

27

Doroshenko, S. I., S. V. Irkha, V. P. Yacovchuk i I. V. Melnick. "SPECIALITY OF FACIAL STRUCTURE IN PATIENTS WITH DEEP BITE FOR THE CALCULATED DATA RESEARCHED BY A.M. SCHWARZ METHOD". Ukrainian Dental Almanac, nr 4 (12.12.2018): 44–49. http://dx.doi.org/10.31718/2409-0255.4.2018.08.

Pełny tekst źródła

Streszczenie:

Deep bite is the most common dental maxillary anomaly in the vertical plane, characterized by elongation of the dental alveolar part in the anterior segment and shortening in the lateral one. At the same time there are different, both the size of the jaws, and their ratio, as well as the position in the skull, which largely depends on the structure of the skull, which is congenital in each person from birth, that is genetically predetermined. The development and structure of the skull, as is known, affects not only genetic factors, but also teratogenic ones, that is, exogenous factors, namely: early loss of teeth, especially temporary, and untimely compensated defects of dentition; bad habits, general human health, the environment etc. All these should be taken into account when establishing the correct diagnosis, which is impossible to do without such objective x-ray methods as cephalometry. The analysis of cephalogram was carried out by A.M. Schwarz method, which included three main sections of the study: craniometric, gnatometric and prophylometric. In craniometric studies, the definition of the following parameters was defined, namely: N-Se length (distance from the bone "N" to "Se" - the middle of the entrance to the «Sella turcica»); the magnitude of the facial angle F (N-Se-N-A) formed by the plane N-Se and the faсial plane - NA; Inclination angle ∟І (∟Pn-SpP) formed by the nasal vertical - Pn and the palatal plane - SpP, which corresponds to the plane of the base of the upper jaw SpP; the corner of the Frankfurt line - ∟H; The angle of inclination of the occlusal plane - OcP to the nasal vertical - is Pn (∟Pn-Ocp) and the angle of the mandibular plane, that is, the plane of the base of the mandible - MP to the nasal vertical - ∟Pn (∟Pn-MP). The main task of craniometric measurements was to determine the individual genetically determined profile of the face in each particular patient with deep bite. Gnatometric measurements included determining the values of the following angles: basal ∟B (∟SpP-MP), that is, the angle of inclination of the plane of the body of the upper and lower jaw to each other; Lower jaw or gonial angle ∟Go (A-MP) Gnatometric studies also included the determination of jaw size: Mandible - the distance of the "OK" and the extension of the wingspan of the FrR; Maxilla - body "MT1" (in the plane of MP from the point "Go" to the intersection of the perpendicular, lowered from the most prominent point of the bone chin "Pgo", and the height of the branch - MT2. Profilometric studies included: determining the thickness of the soft tissues of the patient's face in the back area the nasal «n», the tray is «sna», the upper lip «ls», the lower lip «li» and the chin «pgo», the profile T, formed by the intersection of the tangent from the tray leather point «sna» to the most prominent leather point of the chin "Pgo" with the nose vertex "Pn", as well as the height of the part faccial - medium (from «n» - nasion to «sna» - pidnosovoyi) and lower (from «sna» to the lowest point of the chin «Me»).

Style APA, Harvard, Vancouver, ISO itp.

28

Ar, Assi, Beugre Jb, Gnadoh Jj i Beugre-Kouassi Al. "Diagnose Anthropologique A Partir Des Caractéristiques Dento-Squelettiques Et D’épaisseurs Des Tissus Mous Du Profil Facial: Etude Comparative Entre Population Autochtone Et Diaspora Etrangère". European Scientific Journal, ESJ 12, nr 36 (31.12.2016): 286. http://dx.doi.org/10.19044/esj.2016.v12n36p286.

Pełny tekst źródła

Streszczenie:

Objective : The aim of this study was to search for the particularities in the dento-skeletal and soft tissue thickness of the facial cutaneous profile of Black Ivorians and White Lebanese. Material and methods: This cross-sectional and descriptive study, concerned with numerical radiographs extracted from medical files of 119 adolescent patients [62 Ivorians (34 females and 28 males) and 57 Lebanese (31 females and 26 males)], from 11 to 16 years old, with skeletal class I and normodivergent faces, in first orthodontic surgery. From a drawing on acetate paper (Kodatrace type) and the materialization of true vertical and true horizontal (TVL and THL), 30 landmarks (19 cephalometric and 11 facial cutaneous profile landmarks) allowed the construction of lines and plans as well as 17 dento-skeletal measurements (10 angular et 7 linear) and 12 soft tissue thickness measurements. The data reliability was verified by Dahlberg’s error method, while the t of student on independent series (signification threshold at 0,05) allowed to compare dento-skeletal characteristics and soft tissue thickness of the two groups. The Results : Compared to White Lebanese, Black Ivorians present a facial prognathism resulting in more pronounced protrusion of alveolar bases (SNA= 85,714°, SNB= 81,321°, A-NPerp= 5,768°) and vestibuloversion of central incisives (I/i= 111,679°, I/NA= 7,214mm, i/NB= 9,036mm, NA and NB (I/NA= 27,952° and i/NB= 36,266°) responsible of the obtuser facial convexity (NA-Pog= 169,338°). Indeed, this facial convexity reveals a very low prominence of the chin (Pog-NB= -0,565 mm). Also, the maxillomandibular discrepancy observed (FMA= 24,516°, greater), implies a more important facial growth kinetic in vertical direction with black Ivoirians. This is considerably reduced with females, with a less pronounced FMA angle compared to Lebanese females [FMA° (P=0,211 ns)]. The cutaneous effect of that dento-skeletal prognathism, is tangible through more protrusive lips – hence, thicker - lips (Id-Ls= 13,677 mm and id-Li= 15,919 mm). In this way, the observed substantial thickness is justified, of supporting peri-buccal soft tissue [lower lip’s base (B-Sm= 13,742 mm) and the most inferior part of the chin (Me-Me'= 7,984 mm)]. The two males groups present, however, a soft tissue thickness relatively similar on all the chin surface [Pog-Pog’ (P= 0,393 ns); Gn-Gn’ (P=0,251 ns); Me-Me’ (P=0,245 ns)]. The Black Ivorians’ nose, platyrrhines, low and diving, present a thicker back (Rhi-Rhi’= 3,741 mm) and thin supporting peripheral soft tissue thickness (ENA-Prn = 22,468 mm, Prn perp/Sn-N’=12,935 mm, A-Sn= 13,097 mm) in general. In addition to those specific characteristics of Black Ivorians, males have a thicker soft tissue on the root of the nose (N-N’= 6,769 mm). Among the two female groups, the characteristics of soft tissue thickness are much more contrasted. Thus, besides the traditional morphological features (nose more prominent - so, thicker - with Lebanese females, and thicker lips with Ivorian females), the forehead (G-G’= 6,441mm) and the chin (Pog-Pog’= 13,941mm, GnGn’= 10,471mm, Me-Me’= 8,618mm) of Ivorian females are thicker. Conclusion : The characteristics of dento-skeletal and soft tissue thickness of Black Ivorians and White Lebanese, reflect the anthropological diagnosis of their original ethnical groups. Facial prognathism and acuteness of facial convexity are observed, as well as greater soft tissue thickness of the inferior facial third (especially in females) traditionally particularizing the negroAfricans. However, a morphological proximity of the two ethnic groups is noticeable among males, concerning the soft tissue thickness of the chin, but also in females as for facial divergence. This study, because of what the results highlightened, has a forensic anthropology interest, and reveals the importance of radiological cephalometry.

Style APA, Harvard, Vancouver, ISO itp.

29

Ryan, T. A., L. Li, L. S. Chin, P. Greengard i S. J. Smith. "Synaptic vesicle recycling in synapsin I knock-out mice." Journal of Cell Biology 134, nr 5 (1.09.1996): 1219–27. http://dx.doi.org/10.1083/jcb.134.5.1219.

Pełny tekst źródła

Streszczenie:

The synapsins are a family of four neuron-specific phosphoproteins that have been implicated in the regulation of neurotransmitter release. Nevertheless, knock-out mice lacking synapsin Ia and Ib, family members that are major substrates for cAMP and Ca2+/ Calmodulin (CaM)-dependent protein kinases, show limited phenotypic changes when analyzed electrophysiologically (Rosahl, T.W., D. Spillane, M. Missler, J. Herz, D.K. Selig, J.R. Wolff, R.E. Hammer, R.C. Malenka, and T.C. Sudhof. 1995. Nature (Lond.). 375: 488-493; Rosahl, T.W., M. Geppert, D. Spillane, D., J. Herz, R.E. Hammer, R.C. Malenka, and T.C. Sudhof. 1993. Cell. 75:661-670; Li, L., L.S. Chin, O. Shupliakov, L. Brodin, T.S. Sihra, O. Hvalby, V. Jensen, D. Zheng, J.O. McNamara, P. Greengard, and P. Andersen. 1995. Proc. Natl. Acad. Sci. USA. 92:9235-9239; see also Pieribone, V.A., O. Shupliakov, L. Brodin, S. Hilfiker-Rothenfluh, A.J. Czernik, and P. Greengard. 1995. Nature (Lond.). 375:493-497). Here, using the optical tracer FM 1-43, we characterize the details of synaptic vesicle recycling at individual synaptic boutons in hippocampal cell cultures derived from mice lacking synapsin I or wild-type equivalents. These studies show that both the number of vesicles exocytosed during brief action potential trains and the total recycling vesicle pool are significantly reduced in the synapsin I-deficient mice, while the kinetics of endocytosis and synaptic vesicle repriming appear normal.

Style APA, Harvard, Vancouver, ISO itp.

30

Li, Hui, Le-Qiang Zhu, Bei Xiao, Jie Huang, Shao-Wu Wu, Li-Xun Yang, Zhi-Qiang Zhang i Xiao-Yang Mo. "A new species of the genus Achalinus (Squamata, Xenodermatidae) from southwest Hunan Province, China". ZooKeys 1189 (17.01.2024): 257–73. http://dx.doi.org/10.3897/zookeys.1189.112784.

Pełny tekst źródła

Streszczenie:

A new species of xenodermid snake, Achalinus nanshanensis H. Li, L.-Q. Zhu, Z.-Q. Zhang & X.-Y. Mo, sp. nov., is described based on three specimens collected from Nanshan National Park and Tongdao County of southwest Hunan Province. This new species is genetically distinct amongst its congeners with the mitochondrial COI uncorrected p-distance ranging from 4.4% (in A. yangdatongi) to 17.7% (in A. meiguensis). In addition, this new species can be distinguished from its congeners by a combination of the following morphological characters: (1) dorsal scales with 23 or 25 rows throughout and strongly keeled; (2) tail relatively longer so that TaL/ToL = 0.215–0.248; (3) length of suture between internasals significantly longer than that between prefrontals, LSBI/LSBP = 1.66–1.84; (4) single loreal scale present; (5) SPL 6 in number, with the fourth and fifth contacting eye; (6) IFL 6 in number, with the first three touching the first pair of chin shields; (7) TMP is 2-2-4/2-2(3)-4, with the anterior pair elongated and in contact with the eye; (8) ventrals 2 + 147–158; (9) subcaudals 64–77, unpaired; (10) dorsal body brownish black, with a bright yellow neck collar extending to the head and abdomen in the occipital region. The recognition of the new species increases the number of described Achalinus species to 28, of which 21 are found in China.

Style APA, Harvard, Vancouver, ISO itp.

31

Li, Hongzhen, Wenli Liu, Jianqiong Zhu, Kay Chin i Griffin P. Rodgers. "Abstract 2453: Olfactomedin 4 downregulation enhances MYC-signaling in human benign prostate cells and the Olfm4 mouse models". Cancer Research 83, nr 7_Supplement (4.04.2023): 2453. http://dx.doi.org/10.1158/1538-7445.am2023-2453.

Pełny tekst źródła

Streszczenie:

Abstract Prostate cancer is the most diagnosed solid tumor and the second leading cause of cancer related death in American men. We have reported previously that OLFM4 gene expression was reduced or lost during prostate cancer progression due to frequent genetic deletion and hypermethylation of the OLFM4 gene promoter region. To investigate OLFM4 gene biological functions and molecular mechanisms underlying prostate cancer progression, we have established OLFM4 knock out RWPE1 cells and Olfm4 knock out mouse model. Functionally, OLFM4-knockout RWPE1 cells exhibited enhanced proliferation of the stem/progenitor-like cell population and abnormal differentiation. Bulk-cell RNA sequencing analysis pinpointed that MYC expression was enhanced in the OLFM4-knockout RWPE1 cells compared with OLFM4-wild cells. Molecular and signaling pathway studies revealed an increase in the WNT/APC/MYC signaling pathway gene signature and MYC target genes that regulate multiple biological processes in OLFM4-knockout RWPE1 cells and Olfm4-knock out mouse models. To test the function of the MYC gene in RWPE1 cells, we used (+)-JQ1, an MYC inhibitor, in both 2D and 3D culture models and found that (+)-JQ1 substantially inhibited the proliferation of OLFM4-knockout GFP reporter RWPE1 cells compared with OLFM4-W RWPE1 cells in both types of cultures. We further studied MYC inhibitors using organoid culture for Olfm4-/-/TRAMP mouse prostate tumors. These results suggest that OLFM4-negative prostate cancer is more sensitive to MYC inhibitor’s therapeutic approaches. Citation Format: Hongzhen Li, Wenli Liu, Jianqiong Zhu, Kay Chin, Griffin P. Rodgers. Olfactomedin 4 downregulation enhances MYC-signaling in human benign prostate cells and the Olfm4 mouse models [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 2453.

Style APA, Harvard, Vancouver, ISO itp.

32

Puspitasari, Ayu Laksmi, i Fazwishni Siregar. "Evaluation of Cephalometric Downs Analysis on Cephalograms at RSGM YARSI, Jakarta". YARSI Dental Journal 1, nr 2 (29.02.2024): 59–66. http://dx.doi.org/10.33476/ydj.v1i2.166.

Pełny tekst źródła

Streszczenie:

Introduction: Cephalometric analysis is used to help establish diagnosis and treatment plan in orthodontics. One of the cephalometric analysis is the Downs analysis which its standard values were measured in Caucasians. However, these values cannot be applied to other races and ethnicities because there are racial and ethnic variations. Hence, it is necessary to know the average value for Indonesians. Objective: This study aimed to evaluate Downs analysis on cephalograms at RSGM YARSI Jakarta, compare it with Downs’ norms and other ethnicities, and determine differences between gender. Materials and Methods: Measurements of 10 parameters of Downs analysis were carried out on 29 cephalograms. Data were tested statistically. Results: The mean of the facial angle are 85.17°±3.07; angle of convexity 3.62°±2.79; AB plane angle AB -2.65°±2.55; mandibular plane angle 29.82°±3,37; Y-axis 64.15°±3.34, occlusal plane angle 11°±2.86; interincisal angle 113.06°±7.64; LI-occlusal angle 28.41°±5.24; IMPA angle 10.24°±5.76; distance of UI-APog 8.05 mm±1.85. Discussion: The RSGM YARSI cephalometric value compared to the Downs’ norms shows that the chin towards the FHP is more retroposition, the face is more convex, the relationship of the lower and upper jaw to the NPog is more protrusive, the direction mandibular growth towards the FHP is more vertical, the direction of facial growth is more downward, occlusal growth towards the FHP is steeper, and the incisors are more protruded. The direction of growth in male is more vertical than in female, and there are differences in cephalometric values with other races. Conclusion: There is a significant difference between the Downs cephalometric values of RSGM YARSI and the Downs’ norms in all measurements. Between men and women at RSGM YARSI there are gender differences in the direction of growth. There are differences in measurement values with other races.

Style APA, Harvard, Vancouver, ISO itp.

33

Mitra, Payal, Jorge Azpurua, Huai-Chin Chiang i Rong Li. "Abstract 5568: Understanding the role of immune exclusion in mammary tumor growth". Cancer Research 84, nr 6_Supplement (22.03.2024): 5568. http://dx.doi.org/10.1158/1538-7445.am2024-5568.

Pełny tekst źródła

Streszczenie:

Abstract Multiple solid tumor types, including triple-negative breast cancer (TNBC), respond poorly to immunotherapy due to low infiltration of CD8+ T cells into the tumor core. The extracellular matrix (ECM) and its components such as collagen have been found to contribute to immune cell exclusion. Discoidin domain receptor 1 (DDR1) is a collagen receptor known to be aberrantly expressed in TNBC among multiple solid tumor types. We have uncovered a previously unappreciated function of DDR1 in immune exclusion through shaping a collagen fiber-based tumor defense against anti-tumor immunity (Sun et al, Nature 599, 673-678 (2021)). Our study showed that deletion of DDR1 in mouse mammary carcinoma cell lines such as E0771 and M-Wnt (syngeneic with C57BL/6 strain background) promotes infiltration of CD8+ T cells and reduces tumor growth in an immunocompetent mouse model. Extending the published study to other immunocompetent mouse strain backgrounds, we observed that deletion of DDR1 in EMT6 cells, another immune excluded TNBC mouse model in the BALB/c strain, increased the infiltration of CD8+ T cells to the tumor core and reduced tumor growth. Data concerning the DDR1-dependent spatial architecture of the mammary tumor microenvironment will be presented. Identifying specific immune and stromal cell populations and proteins spatially modified in the presence or absence of DDR1 may aid in development of new stand-alone or combination anti-cancer treatments with anti DDR1 antibody. Citation Format: Payal Mitra, Jorge Azpurua, Huai-Chin Chiang, Rong Li. Understanding the role of immune exclusion in mammary tumor growth [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5568.

Style APA, Harvard, Vancouver, ISO itp.

34

Smith, Richard J. "Philosophy, philology and politics in eighteenth-century China: Li Fu and the Lu-Wang school under the Ch'ing. By Huang Chin-Sheng. pp. 204. Cambridge, Cambridge University Press, 1996. £30.00, US$49.95." Journal of the Royal Asiatic Society 8, nr 2 (lipiec 1998): 309–10. http://dx.doi.org/10.1017/s135618630001035x.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

35

Smart, Marshall C., F. C. Krause i John-Paul Jones. "(Invited) Ester and Carbonate-Based Low Temperature Electrolytes for Operation of Lithium-Ion Batteries in Extreme Environments for NASA Missions". ECS Meeting Abstracts MA2022-02, nr 5 (9.10.2022): 575. http://dx.doi.org/10.1149/ma2022-025575mtgabs.

Pełny tekst źródła

Streszczenie:

NASA continues to have an interest in developing high specific energy and high power rechargeable batteries that can operate well over a wide temperature range. Potential applications that could be enabled or enhanced by such technology include: (i) future Mars and Lunar landers, (ii) future Mars and Lunar rovers, (iii) small robotic missions, and (iv) future planetary aerial vehicles, where high specific energy, high power and wide operating temperature range is desired. Future missions to some of the distant icy moons of Jupiter and Saturn are also anticipated to benefit from improved ultra-low temperature rechargeable batteries with high specific energy.1 A number of terrestrial applications, including automotive and aviation Li-ion batteries, also benefit from having wide temperature range capability. To meet these needs, the Electrochemical Research, Technology, and Engineering Group at the Jet Propulsion Laboratory (JPL) has developed a number of low temperature Li-ion electrolytes utilizing various approaches. Broadly speaking, the performance targets of this work are to provide operation over the temperature range of +60oC to -60oC (delivering over 100 Wh/kg at -40oC at reasonable rates). This paper will provide an overview of the low temperature electrolyte development activities that have taken place at JPL, with a focus on enabling ultra-low temperature operation for extreme environments. The electrolytes evaluated included blends which contain elements of various approaches, including (i) the use of ester co-solvents, (ii) low ethylene carbonate content-based blends, (iii) the use of electrolyte additives, and (iv) the use of mixed lithium electrolyte salts. Experimental studies were performed utilizing three-electrode cells to determine the influence that the electrolyte type has upon the electrode kinetics as a function of temperature. A number of electrochemical techniques were employed to study these cells, including Electrochemical Impedance Spectroscopy (EIS), Tafel polarization, and linear micro-polarization. Improved low temperature capability has been demonstrated in small and large capacity prototype cells with a number of chemistries (i.e., NCO, NCA, NMC, LCO and LFP-based chemistries), including the ability to deliver high specific energy down to -60oC, good charge acceptance at low temperature, and high-power capability at -40oC. Prototype cells incorporating JPL developed electrolytes were obtained from a number of vendors, including (i) Eagle Pitcher Technologies-Yardney Division, (ii) Enersys/Quallion, LLC, (iii) E-One Moli Energy Ltd., (iv) Saft America, and (iv) Navitas/A123. Emphasis was devoted to establishing the charge acceptance characteristics of the cells at very low temperatures, especially below -20oC. Given that lithium plating when charging at low temperatures is a known degradation mode of Li-ion cells in general, attention was focused upon characterizing the conditions in which its likelihood may be more pronounced, determining the influence of electrolyte type, and attempting to detect its occurrence indirectly. Early generations of electrolytes have been utilized in a number of NASA missions, including the 2003 Mars Exploration Rover, 2007 Phoenix Lander, 2011 Mars Science Laboratory (MSL) Curiosity Rover, 2018 Mars InSight Lander, and a JPL/CSUN CubeSat.1-5 Previous work has also targeted improved low temperature performance of Li-ion cells for automotive applications. Current work is focused primarily upon providing higher specific energy coupled with good power characteristics at very low temperatures. Studies have also been performed demonstrating operational capability down to -90oC in some systems, and survival capability to temperatures as low as -135oC. ACKNOWLEDGEMENT The work described here was carried out at the Jet Propulsion Laboratory, California Institute of Technology, under contract with the National Aeronautics and Space Administration (NASA). The information in this document is pre-decisional and is provided for planning and discussion only. REFERENCES M. C. Smart, B. V. Ratnakumar, R. C. Ewell, S. Surampudi, F. Puglia, and R. Gitzendanner, Electrochimica Acta, 268, 27-40 (2018). M. C. Smart, D. Muthulingam, M. E. Lisano, S. F. Dawson, R. B. Shaw, B. T. White, A. Buonanno, C. Deroy, and R. Gitzendanner, 236th Meeting of the Electrochemical Society (ECS), Atlanta, Georgia, October 15, 2019. M. C. Smart, F. C. Krause, and J. -P. Jones, CREB Bi-Annual Meeting, University of Maryland, December 10, 2021. K. B. Chin, G. B. Bolotin, M. C. Smart, S. Katz, J. A. Flynn, N. K. Palmer, E. J. Brandon, and W. C. West, IEEE A&E Systems Magazine, 36 (5), 24-36 (2021). M. C. Smart, B. V. Ratnakumar, F. Charlie Krause, William C. West and Erik J. Brandon, 2021 Space Power Workshop (Virtual), Pasadena, CA, April 19, 2021. M. C. Smart, F. C. Krause, J. -P. Jones, C. L. Fuller, J. A. Schwartz, and B. V. Ratnakumar, 2018 Conference on Advanced Power Systems for Deep Space Exploration, Pasadena, CA, October 22-24, 2018.

Style APA, Harvard, Vancouver, ISO itp.

36

Wang, Hui-Ching, Yu-Min Yeh, Jeng-Shiun Du, Tsung-Jang Yeh, Jui-Hung Tsai, Yu-Chin Gau, Shang Yin Wu, Li-Tzong Chen, Hsiao-Fang Li i Wu-Chou Su. "Abstract CT166: First-in-human phase 1 study of a phosphatidylserine-targeting small molecule drug conjugate (T-1201) in patients with advanced solid tumors". Cancer Research 84, nr 7_Supplement (5.04.2024): CT166. http://dx.doi.org/10.1158/1538-7445.am2024-ct166.

Pełny tekst źródła

Streszczenie:

Abstract Background Phosphatidylserine (PS), a phospholipid, is an essential component of bilayer cell membranes and is normally present in the inner cell membrane layer of the cells. In rapid proliferating cancer cells, PS externalizes to the outer cell membrane and has the potential to act as a tumor biomarker and therapeutic target. T-1201 is a small molecule drug conjugate comprised of a phosphatidylserine-targeting head, Zinc (II) bis-dipicolylamine (Zn-DPA), linked to bioactive topoisomerase I inhibitor SN-38. Once T-1201 via Zn-DPA targets tumor cells, then enzymatic cleavage releases the cytotoxic payload of SN38, the active metabolite of irinotecan. This leads to high accumulation of antineoplastic drug directly in the tumor microenvironment. Here, we describe a trial in progress of a first-in-human trial of T-1201 in patients with advanced solid tumors. Methods This first-in-human, open-label, multicenter, phase I trial (NCT04866641) is investigating the safety, tolerability, pharmacokinetics and antitumor activity of T-1201 administrated as monotherapy to subjects with advanced solid tumors. Eligible patients have ≥ 1 measurable lesion per RECIST v1.1. and no effective standard therapy exists. T-1201 is administered intravenously once every 4 weeks (Q4W) in 28-day cycles with dose escalation guided by an accelerated titration design. The study started with 1 subject enrolled per cohort. With 100% dose increment for the next cohort. If 1 subject experiences any ≥ Grade 2 AE or DLT at any dose level during first cycle, the dose escalation will transit to 3+3 design where dose increment will follow a modified Fibonacci sequence. Starting with Cycle 2, the dosing interval can be adjusted to once every two weeks (Q2W) and the dose level after switching to Q2W schedule will be half of that at Q4W. Intra-subject dose escalation is permitted to maximize the likelihood of responses while keeping toxicity acceptable for individual subjects. The dose can be increased after subjects complete at least 2 treatment cycles at a particular dose level without experiencing any > grade 2 drug-related toxicity. The primary endpoints are the maximum tolerated dose (MTD), recommended Phase 2 dose (RP2D) and adverse event rate as measured by CTCAE v5.0. Secondary endpoints include objective response rate (ORR), clinical benefit rate (CBR), duration of response (DOR) and time to tumor progression. This study has begun enrolling patients and is continuing as planned in Taiwan. 77% of planned patients have been enrolled as of November 2023. Citation Format: Hui-Ching Wang, Yu-Min Yeh, Jeng-Shiun Du, Tsung-Jang Yeh, Jui-Hung Tsai, Yu-Chin Gau, Shang Yin Wu, Li-Tzong Chen, Hsiao-Fang Li, Wu-Chou Su. First-in-human phase 1 study of a phosphatidylserine-targeting small molecule drug conjugate (T-1201) in patients with advanced solid tumors [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 2 (Late-Breaking, Clinical Trial, and Invited Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(7_Suppl):Abstract nr CT166.

Style APA, Harvard, Vancouver, ISO itp.

37

Zhou, Yifan, Yusra B. Medik, Bhakti Patel, Daniel B. Zamler, Sijie Chen, Thomas Chapman, Sarah Schneider i in. "Abstract 5545: Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration". Cancer Research 82, nr 12_Supplement (15.06.2022): 5545. http://dx.doi.org/10.1158/1538-7445.am2022-5545.

Pełny tekst źródła

Streszczenie:

Abstract Immunotherapies such as anti-CTLA-4 immune checkpoint blockade (ICB) have revolutionized cancer treatment, yet quality of life and continuation of therapy can be constrained by off-target tissue damage or immune-related adverse events (irAEs). At present, there is limited understanding of irAE mechanisms, hampering development of approaches to mitigate their damage. We addressed this problem by generating animal models of intestinal irAE. Our results show that disruption of homeostatic immunity by genetic predisposition to intestinal inflammation or acute gastrointestinal infection sensitizes mice to anti-CTLA-4-mediated intestinal toxicity. Inflammation-prone mice treated with anti-CTLA-4 showed neutrophil accumulation, systemic interleukin-6 (IL-6) release, and dysbiosis. Significantly, IL-6 blockade combined with antibiotic treatment improved anti-CTLA-4 therapeutic efficacy and reduced intestinal irAEs. Immune signatures were validated in biopsies from patients who developed colitis during ICB, supporting the utility of our models. This study provides new pre-clinical models, mechanistic insight into irAEs, and potential approaches to enhance ICB efficacy while mitigating irAEs. Citation Format: Yifan Zhou, Yusra B. Medik, Bhakti Patel, Daniel B. Zamler, Sijie Chen, Thomas Chapman, Sarah Schneider, Rachel L. Babcock, Taylor T. Chrisikos, Laura M. Kahn, Allison M. Dyevoich, Elizabeth M. Park, Alexandria P. Cogdill, Daniel H. Johnson, Sarah B. Johnson, Khalida M. Wani, Debora A. Ledesma, Courtney W. Hudgens, Jingjing Wang, Md Abdul Wadud Khan, Aron Y. Joon, Weiyi Peng, Haiyan S. Li, Reetakshi Arora, Ximing Tang, Maria Gabriela Raso, Xuegong Zhang, Wai Chin Foo, Michael T. Tetzlaff, Gretchen E. Diehl, Karen Clise-Dwyer, Elizabeth M. Whitley, Matthew M. Gubin, James P. Allison, Patrick Hwu, Nadim J. Ajami, Adi Diab, Jennifer A. Wargo, Stephanie S. Watowich. Intestinal toxicity to CTLA-4 blockade driven by IL-6 and myeloid infiltration [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 5545.

Style APA, Harvard, Vancouver, ISO itp.

38

Chan, Michael W. Y., Yin-Chen Chen, Ching-Wen Lin, Frank Cheng, Ching-Cher Sanders Yan, Chao-Ping Hsu, Yu-Min Chuang i in. "Abstract 97: A E2F6 ceRNA network suppresses dendritic cell function, via PBX1/IL-10 signaling, in ovarian cancer". Cancer Research 84, nr 6_Supplement (22.03.2024): 97. http://dx.doi.org/10.1158/1538-7445.am2024-97.

Pełny tekst źródła

Streszczenie:

Abstract It is reported that long-term use of estrogen could increase the risk of ovarian cancer. However, the role of estrogen in immunoevasion is not fully explored. We have previously demonstrated that estrogen-mediated upregulation of E2F6, and, c-Kit, by epigenetic silencing of miR-193a, and a competing endogenous (ceRNA) mechanism. In this study, we found that PBX1, a transcriptional activator of the immunosuppressive cytokine, IL-10, is also a target of miR-193a. Importantly, overexpression of the E2F6 3’UTR upregulates both E2F6 and, PBX1, as well as IL10 in ovarian cancer cell lines, suggesting that ceRNA mechanism exists between E2F6 and PBX1. These phenomena are further supported by our stochastic simulation of the estrogen-mediated E2F6 ceRNA network on the distribution of E2F6 and PBX1 mRNA in cancer cells, which is consistent with the TCGA ovarian cancer RNA-Seq dataset. Importantly, monocyte-derived dendritic cell activation of T-cell function was inhibited by pretreatment of conditioned media derived from ovarian cancer cells overexpressing E2F6 3’UTR; such inhibition was rescueable by an anti-IL-10 antibody. Clinically, IL10 level was higher in ovarian cancer patients with higher E2F6 and PBX1, and in ovarian cancer cell lines overexpressed with E2F6 3’UTR. Taken together, these results showed that E2F6 could suppress anti-tumor immune response of dendritic cell, E2F6 ceRNA network. Epigenetic intervention in restoring the expression of miR-193a may be able to enhance anti-tumor immune response against ovarian cancer. Citation Format: Michael W.Y. Chan, Yin-Chen Chen, Ching-Wen Lin, Frank Cheng, Ching-Cher Sanders Yan, Chao-Ping Hsu, Yu-Min Chuang, Jie-Ting Low, Xiaojing Ma, Yao-Ting Huang, Chia-Bin Chang, Chin Li, Hung-Cheng Lai, Shu-Fen Wu, Shih-Hsun Hung, Je-Chiang Tsai. A E2F6 ceRNA network suppresses dendritic cell function, via PBX1/IL-10 signaling, in ovarian cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 97.

Style APA, Harvard, Vancouver, ISO itp.

39

Wang, W., T. Zhang, L. Wang i H. Song. "FRI0472 DIAGNOSIS AND MANAGEMENT OF ADENOSINE DEAMINASE 2 DEFICIENCY CHILDREN: THE EXPERIENCE FROM CHINA". Annals of the Rheumatic Diseases 79, Suppl 1 (czerwiec 2020): 833.1–833. http://dx.doi.org/10.1136/annrheumdis-2020-eular.3481.

Pełny tekst źródła

Streszczenie:

Background:Adenosine deaminase 2 deficiency (DADA2) is a rare antoinflammatory disease caused by mutations in ADA2 gene, few Chinese cases have been reported.Objectives:To describe and compare the clinical features, genotypes, and treatments of Chinese DADA2 patients and foreign cases.Methods:Primary immunodeficiency disease Panel or Whole Exome Sequencing was performed to suspected subjects, and assays for adenosine deaminase 2(ADA2) enzyme activity were also carried out to them and their parents. Case reports of Chinese and foreign patients with DADA2 were searched from PubMed and Chinese domestic databases.Results:Seven unrelated DADA2 children from China were included in our study, 5 were identified at Peking union medical college hospital and 2 had been reported previously (1 on PubMed and 1 in Chinese literatures). 14 mutations in ADA2 were identified, and 9 of which have not been found in other countries. Four children receiving enzymatic analysis had lower ADA2 enzyme activity compared to their parents. Phenotypic manifestations included fever, skin symptoms, vasculitis, neurologic involvement, et al. The treatments varying from steroids, immunosuppressants, and tocilizumab, anti-TNF therapy and hematopoietic stem cell transplantation (HSCT) were effective depending on different phenotype and severity.Conclusion:This study includes the biggest number of Chinese DADA2 patients at present. We recommend combination of enzymatic analysis with gene screening to confirm the diagnosis. Genotypes of patients from China were some different, the clinical manifestations were similar. We suggest anti-TNF therapy may not be necessary for mild case and HSCT should be considered even without hematological phenotype.References:[1]Zhou Q, Yang D, Ombrello AK, Zavialov AV, Toro C, Zavialov AV, et al. Early-onset stroke and vasculopathy associated with mutations in ADA2. N Engl J Med. 2014;370:911-920.[2]Meyts I, Aksentijevich I. Deficiency of Adenosine Deaminase 2 (DADA2): Updates on the Phenotype, Genetics, Pathogenesis, and Treatment. J Clin Immunol. 2018;38:569-578.[3]Wang XN, Zhou ZX, Li SN, Lai JM, Su GX, Kang M, et al. A case report of DADA2. Chin J Rheumatol. 2019;23:476-478.[4]Liu L, Wang W, Wang Y, Hou J, Ying W, Hui X, et al. A Chinese DADA2 patient: report of two novel mutations and successful HSCT. Immunogenetics. 2019;71:299-305.Disclosure of Interests:None declared

Style APA, Harvard, Vancouver, ISO itp.

40

Cox, Orla T., Stephanie Ward, Emilie Tresse i Rosemary O'Connor. "Abstract 2528: PDLIM2 expression in triple negative breast cancer stromal macrophages". Cancer Research 82, nr 12_Supplement (15.06.2022): 2528. http://dx.doi.org/10.1158/1538-7445.am2022-2528.

Pełny tekst źródła

Streszczenie:

Abstract PDLIM2 is a PDZ-LIM domain protein expressed in hematopoietic and epithelial cells that regulates the stability of transcription factors including NFΚB, STATs and beta catenin. PDLIM2 function is associated with tumour suppression and also with the acquisition of a metastatic or epithelial mesenchymal transition (EMT) phenotype. We recently showed that PDLIM2 is more highly expressed in Triple Negative Breast Cancer (TNBC) tumours than in other breast cancer types or normal breast tissue, and that this is associated with active beta catenin in TNBC (1). Interestingly, in PDLIM2-positive TNBC tumours, PDLIM2 was also present in the tumour-associated stroma. However, whether stromal PDLIM2 expression contributes to TNBC cancer progression is unknown. To investigate this further we assessed the phenotype of PDLIM2-expressing stromal cells and determined that they most strongly represented a M2-like macrophage population. We then investigated the requirement for PDLIM2 in polarization towards either the M1 and M2-like macrophage phenotype using cultured bone marrow-derived macrophages from PDLIM2 knockout mice compared with wild type. This demonstrated that PDLIM2 is required for full adoption of IL-4-induced M2 macrophage polarization and function, including cell adhesion and migration. M1 polarization was less dependent on PDLIM2, although potential for activation of STATs and NFKB was similar in both macrophage populations.We conclude that high expression of PDLIM2 in TNBC influences the tumour microenvironment through the presence of an M2 macrophage population. Reference: (1) Cox, O. T., Edmunds, S. J., Simon-Keller, K., Li, B., Moran, B., Buckley, N. E., Bustamante-Garrido, M., Healy, N., O'flanagan, C. H., Gallagher, W. M., Kennedy, R. D., Bernards, R., Caldas, C., Chin, S. F., Marx, A. & O'Connor, R. 2019. Pdlim2 Is A Marker Of Adhesion And Beta-Catenin Activity In Triple-Negative Breast Cancer. Cancer Res, 79, 2619-2633. Citation Format: Orla T. Cox, Stephanie Ward, Emilie Tresse, Rosemary O'Connor. PDLIM2 expression in triple negative breast cancer stromal macrophages [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2528.

Style APA, Harvard, Vancouver, ISO itp.

41

Li, Hongzhen, Wenli Liu, Jianqiong Zhu, Kyung Chin i Griffin P. Rodgers. "Abstract 1548: Olfactomedin 4 deficiency promote de novo progression of prostate cancer in TRAMP mouse model". Cancer Research 84, nr 6_Supplement (22.03.2024): 1548. http://dx.doi.org/10.1158/1538-7445.am2024-1548.

Pełny tekst źródła

Streszczenie:

Abstract Prostate cancer is the most diagnosed solid tumor and the second leading cause of cancer-related death in American men. Olfactomedin (OLFM4) plays tumor suppressor roles and is associated with the initiation, growth, and clinical outcome of human prostate cancer. Olfm4-null mouse sporadically developed prostate epithelial neoplasia through up-regulated hedgehog signaling pathways. In this study, we have generated Olfm4+/+/GFP/TRAMP and Olfm4−/−/TRAMP mouse models to investigate Olfm4 gene biological functions underlying prostate cancer de novo progression. We have observed that Olfm4−/−/TRAMP mice developed more advanced prostate cancer at 47.6% (20/42) compared to Olfm4+/+/TRAMP at 11.9 % (5/42) and had poor survival compared to Olfm4+/+/TRAMP mice (P<0.01). Histopathological and immunofluorescent staining revealed that tumor tissues containing more heterogeneous cells such as Ar+/Ck8+ epithelial or Syn+ neuroendocrinal cells or Vim+/Ck8+ epithelium mesenchymal transition cells in the primary tumors obtained from Olfm4−/−/TRAMP mouse. We found more tumor angiogenesis and metastases into lymph nodes, liver, lung, kidney, and soft tissues in Olfm4−/−/TRAMP mice. The accumulations of the dendritic cell population in primary tumor and lung metastasis tumors were detected. The primary tumor was sensitive to androgen deprivation therapy by using castration with both Olfm4+/+/GFP/TRAMP and Olfm4−/−/TRAMP mice. However, castration-resisted EMT tumor cells or expressing neuroendocrine marker cells regrew after castration 7-8 months in both Olfm4+/+/GFP/TRAMP and Olfm4−/−/TRAMP mice. Furthermore, we tested JQ1, a BET bromodomain inhibitor, as an epigenetic targeted therapy reagent and found that JQ1 significantly inhibited tumor cell growth of Olfm4−/−/TRAMP mouse tumor in the organoids culture. Taken together, we have provided novel evidence that Olfm4 plays a tumor-suppressing role during prostate cancer de novo progression. Citation Format: Hongzhen Li, Wenli Liu, Jianqiong Zhu, Kyung Chin, Griffin P. Rodgers. Olfactomedin 4 deficiency promote de novo progression of prostate cancer in TRAMP mouse model [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1548.

Style APA, Harvard, Vancouver, ISO itp.

42

Chiang, Huai-Chin, Leilei Qi, Yanfen Hu i Rong Li. "Abstract 3019: Dissecting in vivo functions of R-Loops in Brca1-associated DNA replication stress and mammary tumorigenesis". Cancer Research 84, nr 6_Supplement (22.03.2024): 3019. http://dx.doi.org/10.1158/1538-7445.am2024-3019.

Pełny tekst źródła

Streszczenie:

Abstract Germ-line BRCA1 mutations are associated with a significantly increased incidence of breast cancer in women. Although BRCA1-associated breast tumors are basal-like and estrogen receptor α negative (ERα−), they originate from luminal progenitor cells. At the molecular level, BRCA1 is best known for its roles in resolution of DNA replication stress and promotion of homologous recombination (HR)-based double strand break (DSB) repair. In addition, BRCA1 is implicated in reduction of R-loops, a DNA-RNA hybrid structure and transcriptional byproduct associated with genome instability and transcriptional regulation. Our published findings suggest that BRCA1-dependent R-loop mitigation contributes to luminal cell-specific transcription and differentiation (Zhang et al, 2017, Nature Communications, 8:15908), which could in turn suppress Brca1-associated tumorigenesis. Using cell type-specific mouse genetics, we investigate a direct impact of R-loop removal on Brca1-associated mammary epithelial tumor formation. R-loop formation in mammary epithelial cells is efficiently reduced by over-expression of RNase H1, an R-loop-specific ribonuclease. R-loop removal does not affect mammary duct development or function. However, it drastically increases ɣH2AX foci in proliferating BRCA1-deficient epithelial cells without external DNA damage. This suggests a role of R-loops in attenuating elevated DNA replication stress caused by the loss of Brca1. While R-loop removal does not appear to affect the overall Brca1-associated mammary tumor incidence, it promotes cell differentiation from ERα− luminal progenitor cells to ERα+ mature luminal cells. Accordingly, unlike their counterparts, a significant percentage of Brca1-associated mammary tumors with RNase H1 overexpression tend to be ERα+. Thus, our findings provide in vivo evidence for a previously unappreciated role of R-loop dynamics on Brca1-associated DNA replication stress and tumor development in mammary epithelium. Citation Format: Huai-Chin Chiang, Leilei Qi, Yanfen Hu, Rong Li. Dissecting in vivo functions of R-Loops in Brca1-associated DNA replication stress and mammary tumorigenesis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 3019.

Style APA, Harvard, Vancouver, ISO itp.

43

Nascimento, Victor Alves, Jovânia Alves Oliveira, Mariana Nunes Godoi Moreira, Jader Bueno de Oliveira, Vinicius Rafael Gonzaga i Marcela Filié Haddad. "Características clínicas e efeitos do Covid-19 nos pacientes idosos: uma revisão integrativa". ARCHIVES OF HEALTH INVESTIGATION 9, nr 6 (20.12.2020): 617–22. http://dx.doi.org/10.21270/archi.v9i6.5268.

Pełny tekst źródła

Streszczenie:

Introdução: A COVID-19 tornou-se uma emergência de saúde pública no ano de 2020, sendo caracterizada como pandemia no mês de março. Os idosos compõem o grupo de risco dessa doença. Objetivo: Avaliar os efeitos da pandemia de COVID-19 sobre os idosos. Material e Método: A busca pelos artigos foi realizada através da plataforma Pubmed, com a inclusão de 17 estudos. Resultados: Os resultados ressaltaram a prevalência da doença entre a população idosa, e evidenciaram que esse grupo apresenta sintomas atípicos e com duração ligeiramente mais longa desde o início da sintomatologia até a sua admissão, tornando-se mais difícil a identificação da infecção de forma precoce. As manifestações clínicas mais relatadas foram: febre, tosse, produção de escarro, diarreia, fadiga, pneumonia e lesão cardíaca aguda. Também se observa que comorbidades, como hipertensão e doença pulmonar obstrutiva crônica, levam a uma disfunção cardíaca e pulmonar devido a mudanças fisiológicas e anatômicas dos pulmões, agravando o quadro clínico dos pacientes. Os exames de imagem se mostraram grandes aliados ao diagnóstico das alterações pulmonares decorrentes da infecção, além da realização do exame RT-PCR. Conclusão: Os idosos compõem o grupo de risco da COVID-19, sendo indivíduos com comorbidades os mais susceptíveis à agravamentos clínicos. Há necessidades em seguir as recomendações da OMS por não haver um tratamento específico destinado a essa patologia. Descritores: Infecções por Coronavírus; Idoso; Diagnóstico Clínico. Referências World Health Organization [homepage internet]. Pandemia de doença por coronavirus (COVID-19) [acesso em 19 nov 2020]. Disponível em: http: https://www.who.int/emergencies/diseases/novel-coronavirus-2019?gclid=CjwKCAiAzN j9BRBDEiwAPsL0d-MtvP29HNfG_fKThMRyfZF5ZAhTrrwKXEDh74AOZlY7ddRjJ_su0 hoCK3EQAvD_BwE. Organização Pan-Americana de Saúde [homepage na internet]. Folha informativa COVID-19 - Escritório da OPAS e da OMS no Brasil [acesso em: 19 nov. 2020]. Disponível em: https://www.paho.org/pt/covid19. Ministério da Saúde [homepage na internet]. Painel Coronavirus Brasil [acesso em: 19 nov. 2020]. Disponível em: http:https://covid.saude.gov.br/. Liu K, Zhang W, Yang Y, Zhang J, Li Y, Chen Y. Respiratory rehabilitation in elderly patients with COVID-19: A randomized controlled study. Complement The Clin Pract. 2020:101166. Lee JY, Kim HA, Huh K, Hyun M, Rhee J-Y, Jang S, et al. Risk Factors for Mortality and Respiratory Support in Elderly Patients Hospitalized with COVID-19 in Korea. J Korean Med Sci. 2020;35(23) Nikpouraghdam M, Farahani AJ, Alishiri G, Heydari S, Ebrahimnia M, Samadinia H, et al. Epidemiological characteristics of coronavirus disease 2019 (COVID-19) patients in IRAN: A single center study. J Clin Virol. 2020; 127:104378. Zheng Y, Xu H, Yang M, Zeng Y, Chen H, Liu R, et al. Epidemiological characteristics and clinical features of 32 critical and 67 noncritical cases of COVID-19 in Chengdu. J Clin Virol. 2020;127:104366. Porcheddu R, Serra C, Kelvin D, Kelvin N, Rubino S. Similarity in case fatality rates (CFR) of COVID-19/SARS-COV-2 in Italy and China. J Infect Dev Ctries. 2020;14(02):125-8. Buckner FS, McCulloch DJ, Atluri V, Blain M, McGuffin SA, Nalla AK, et al. Clinical Features and Outcomes of 105 Hospitalized patients with COVID-19 in Seattle, Washington. Clin Infect Dis. 2020;71(16):2167-73. Liu K, Fang Y-Y, Deng Y, Liu W, Wang M-F, Ma J-P, et al. Clinical characteristics of novel coronavirus cases in tertiary hospitals in Hubei Province. Chin Med J. 2020;133(9):1025-31. Zhao M, Wang M, Zhang J, Gu J, Zhang P, Xu Y, et al. Comparison of clinical characteristics and outcomes of patients with coronavirus disease 2019 at different ages. Aging (Albany NY). 2020;12(11):10070. Wang L, He W, Yu X, Hu D, Bao M, Liu H, et al. Coronavirus disease 2019 in elderly patients: Characteristics and prognostic factors based on 4-week follow-up. J Infect. 2020;80(6):639-45. Guo T, Shen Q, Guo W, He W, Li J, Zhang Y, et al. Clinical Characteristics of Elderly Patients with COVID-19 in Hunan Province, China: A Multicenter, Retrospective Study. Gerontol. 2020:1-9. Ward CF, Figiel GS, McDonald WM. Altered Mental Status as a Novel Initial Clinical Presentation for COVID-19 Infection in the Am J Geriatr Psychiatry. 2020;28(8):808-11. Liu K, Chen Y, Lin R, Han K. Clinical features of COVID-19 in elderly patients: A comparison with young and middle-aged patients. J Infect. 2020;80(6):e-14-8. Li T, Zhang Y, Gong C, Wang J, Liu B, Shi L, et al. Prevalence of malnutrition and analysis of related factors in elderly patients with COVID-19 in Wuhan, China. Eur J Clin Nutr. 2020:1-5. Niu S, Tian S, Lou J, Kang X, Zhang L, Lian H, et al. Clinical characteristics of older patients infected with COVID-19: A descriptive study. Arch Gerontol Geriatr. 2020;89:104058. Fatyga E, Dzięgielewska-Gęsiak S, Wierzgoń A, Stołtny D, Muc-Wierzgoń M. The coronavirus disease 2019 pandemic: telemedicine in elderly patients with type 2 diabetes. Pol Arch int Med. 2020;130(5):452-54. Li P, Chen L, Liu Z, Pan J, Zhou D, Wang H, et al. Clinical Features and Short-term Outcomes of Elderly Patients With COVID-19. Int J Infect Dis. 2020;97:245-50. Kumar A, Kubota Y, Chernov M, Kasuya H. Potential Role of Zinc Supplementation in Prophylaxis and Treatment of COVID-19. Med Hypotheses. 2020;144:109848.

Style APA, Harvard, Vancouver, ISO itp.

44

Ellis, Brian L., Kyu Tae Lee i Linda F. Nazar. "ChemInform Abstract: Positive Electrode Materials for Li-Ion and Li-Batteries". ChemInform 41, nr 31 (9.07.2010): no. http://dx.doi.org/10.1002/chin.201031221.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

45

HOFMANN, J., R. BRANDES i R. HOPPE. "ChemInform Abstract: New Silicates with “Stuffed Pyrgoms”: CsKNaLi9(Li(SiO4))4 (I), CsKNa2Li8(Li(SiO4))4 (II), RbNa3Li8(Li(SiO4))4 (III) and RbNaLi4(Li( SiO4))2 (IV)." ChemInform 25, nr 50 (18.08.2010): no. http://dx.doi.org/10.1002/chin.199450009.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

46

Yao, Li-Chin, Shantashri Vaidya, Pali Kaur, James G. Keck, Leonard D. Shultz, Dale L. Greiner i MIchael A. Brehm. "Abstract 1640: Enhanced development of functional human innate immune cells in a novel FLT3nullNSG mouse strain expressing human FLT3L". Cancer Research 82, nr 12_Supplement (15.06.2022): 1640. http://dx.doi.org/10.1158/1538-7445.am2022-1640.

Pełny tekst źródła

Streszczenie:

Abstract Humanized mice are being applied widely to study human immune system homeostasis, function, and as a testing platform for cancer immunotherapies. A major limitation for many humanized mouse models is the lack of functional and mature human innate immune cells, which are critical for effective human immune system-tumor interactions. Previous studies have demonstrated that delivery of human FLT3L into immunodeficient mice that lack mouse FLT3, promotes the development of human innate immune cell subsets following engraftment with human hematopoietic stem cells (HSC). Here we describe a NOD-scid IL2rgnull (NSG) mouse that lacks the expression of mouse FLT3 and expresses human FLT3L transgenically (NSG-mFLT3nullTg (HuFLT3L) or NSG-FLT3L. In these studies, NSG-FLT3L and NSG mice were engrafted with human umbilical cord blood (UCB) CD34+ HSC and compared for human immune system development and function. HSC-engrafted NSG-FLT3L and NSG mice show similar levels of total human CD45+ cells in blood over the course of 18 weeks post-engraftment. However, HSC-engrafted NSG-FLT3L mice show significantly higher levels of human CD141+ and CD1c+ DC subsets, CD123+ pDC, CD14+ monocytes, CD56+ NK cells and CD3+ T cells in the blood as compared to NSG mice. CD34-FLT3L mice also show increased levels of human immune cell infiltration into the gut mucosa. CD56+ NK cells and CD3+ T cells from HSC-engrafted NSG-FLT3L mice express granzyme A and granzyme B, indicating cytotoxic activity. Following treatment of HSC-engrafted NSG-FLT3L mice with LPS, heightened levels of human cytokines were detected in serum samples, confirming innate immune system function. The growth kinetics of tumor cells from a triple negative breast cancer cell line MDA-MB-231 and a lung PDX model LG1306 in HSC-engrafted NSG-FLT3L mice are work in progress and will be compared with HSG-engrafted NSG mice. Overall these results demonstrate that the NSG-FLT3L model supports enhanced development of functional, human innate immune cells and is a novel tool to study human immuno-oncology. Citation Format: Li-Chin Yao, Shantashri Vaidya, Pali Kaur, James G. Keck, Leonard D. Shultz, Dale L. Greiner, MIchael A. Brehm. Enhanced development of functional human innate immune cells in a novel FLT3nullNSG mouse strain expressing human FLT3L [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 1640.

Style APA, Harvard, Vancouver, ISO itp.

47

Lin, Yi-Syuan, Ya-Chuan Tsai, Chia-Jung Li, Tzu-Tang Wei, Ya-Na Wu, Shang-Rung Wu, Shin-Chin Lin, Shaw-Jenq Tsai i Shih-Chieh Lin. "Abstract 1372: NUDT16L1 promotes colon cancer progression via inhibition of ferroptosis". Cancer Research 83, nr 7_Supplement (4.04.2023): 1372. http://dx.doi.org/10.1158/1538-7445.am2023-1372.

Pełny tekst źródła

Streszczenie:

Abstract Ferroptosis is an iron-dependent oxidative cell death with accumulation of lipid peroxidation and abnormal morphology of mitochondria. Although previous studies have shown that ferroptosis inducers have therapeutic potentials in several treatment-naive and drug-resistant cancer types, lacking systematic analysis of the ferroptosis sensitivity in different cancer types makes it difficult to know which cancer type is suitable for clinical usage and critical regulator determining the ferroptosis sensitivity during cancer progression is still not clear. In this study, colon cancer was identified as one of the ferroptosis-insensitive cancer types by dry and wet bench analyses. Importantly, our large-scale analysis also showed that NUDT16L1 was a novel ferroptosis repressor and overexpressed in colon cancer clinical specimens. Similar findings are also observed in the chemical-induced and genetic mouse models of colon cancer. Furthermore, NUDT16L1 loss-of-function and gain-of-function cell models and its conditional knock-in and knock-out mouse models are used to prove its crucial role in the development of colon cancer. In addition, loss of NUDT16L1 induced several key ferroptosis characteristics and impairment of mitochondrial functions while its restoration attenuated those phenomena in colon cancer cells. Mechanistically, our RNA-Seq and RIP-Seq analyses shown that NUDT16L1 directly interacted and positively regulated several crucial negative regulators of ferroptosis. More interestingly, loss of NUDT16L1 not only restores the sensitivity of ferroptosis inducer but also impairs the function of mitochondria. Finally, a specific NUDT16L1 inhibitor was shown to not only repress colon cancer growth in vitro and in vivo but also induce the ferroptosis in colon cancer. In conclusion, this is the first study to demonstrate that overexpression of NUDT16L1 promotes colon cancer progression by inhibition of ferroptosis and maintenance proper function of mitochondria. Furthermore, specific NUDT16L1 inhibitor might be a promising therapeutic strategy for colon cancer patient in the future. Citation Format: Yi-Syuan Lin, Ya-Chuan Tsai, Chia-Jung Li, Tzu-Tang Wei, Ya-Na Wu, Shang-Rung Wu, Shin-Chin Lin, Shaw-Jenq Tsai, Shih-Chieh Lin. NUDT16L1 promotes colon cancer progression via inhibition of ferroptosis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1372.

Style APA, Harvard, Vancouver, ISO itp.

48

Hong, Jing Han, Chern Han Yong, Hong Lee Heng, Jason Yongsheng Chan, Mai Chan Lau, Jianfeng Chen, Jing Yi Lee i in. "Abstract LT09: Integrative Multi-Omics Enhancer Activity Profiling Identifies Therapeutic Vulnerabilities in Cholangiocarcinoma of Different Etiologies". Cancer Research 84, nr 8_Supplement (15.04.2024): LT09. http://dx.doi.org/10.1158/1538-7445.fcs2023-lt09.

Pełny tekst źródła

Streszczenie:

Abstract Objectives: Cholangiocarcinoma (CCA) is a heterogeneous malignancy with high mortality and dismal prognosis, and an urgent clinical need for new therapies. Knowledge of the CCA epigenome is largely limited to aberrant DNA methylation. Dysregulation of enhancer activities has been identified to affect carcinogenesis and leveraged for new therapies but is uninvestigated in CCA. Our aim is to identify potential therapeutic targets in different subtypes of CCA through enhancer profiling. Design: Integrative multi-omics enhancer activity profiling of diverse CCA was performed. A panel of diverse CCA cell lines, and patient-derived and cell line-derived xenografts were used to study identified enriched pathways and vulnerabilities. NanoString, multiplex immunohistochemistry staining, and single-cell spatial transcriptomics were used to explore immunogenicity of diverse CCA. Results: We identified 3 distinct groups, associated with different etiologies and unique pathways. Drug inhibitors of identified pathways reduced tumor growth in in-vitro and in-vivo models. The first group (ESTRO), with mostly fluke-associated CCAs, displayed activation in estrogen signaling and were sensitive to MTOR inhibitors. Another group (OXPHO), with mostly BAP1 and IDH-mutant CCAs, displayed activated oxidative phosphorylation pathways, and were sensitive oxidative phosphorylation inhibitors. Immune-related pathways were activated in the final group (IMMUN), made up of an immunogenic CCA subtype and CCA with aristolochic acid (AA) mutational signatures. Intra-tumor differences in AA mutation load were correlated to intra-tumor variation of different immune cell populations. Conclusion: Our study elucidates the mechanisms underlying enhancer dysregulation and deepens understanding of different tumorigenesis processes in distinct CCA subtypes, with potential significant therapeutics and clinical benefits. Citation Format: Jing Han Hong, Chern Han Yong, Hong Lee Heng, Jason Yongsheng Chan, Mai Chan Lau, Jianfeng Chen, Jing Yi Lee, Abner Herbert Lim, Zhimei Li, Peiyong Guan, Pek Lim Chu, Sheng Rong Ng, Xiaosai Yao, Peili Wang, Rong Xiao, Xian Zeng, Yichen Sun, Wei Liu, Joanna Koh, Felicia Yu Ting Wee, Jeffrey Chun Tatt Lim, Cedric Chuan Young Ng, Xiu Yi Kwek, Poramate Klanrit, Yaojun Zhang, Jiaming Lai, David Wai Meng Tai, Chawalit Pairojkul, Simona Dima, Irinel Popescu, Sen-Yung Hsieh, Ming-Chin Yu, Joe Yeong, Sarinya Kongpetch, Apinya Jusakul, Watcharin Loilome, Patrick Tan, Jing Tan, Bin Tean Teh. Integrative Multi-Omics Enhancer Activity Profiling Identifies Therapeutic Vulnerabilities in Cholangiocarcinoma of Different Etiologies [abstract]. In: Proceedings of Frontiers in Cancer Science; 2023 Nov 6-8; Singapore. Philadelphia (PA): AACR; Cancer Res 2024;84(8_Suppl):Abstract nr LT09.

Style APA, Harvard, Vancouver, ISO itp.

49

Reckeweg, Olaf, Armin Schulz, Bjoern Blaschkowski, Thomas Schleid i Francis J. DiSalvo. "ChemInform Abstract: Single-Crystal Structures and Vibrational Spectra of Li[SCN] and Li[SCN]·2H2O." ChemInform 45, nr 14 (21.03.2014): no. http://dx.doi.org/10.1002/chin.201414002.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

50

PISTOIA, G., i A. ANTONINI. "ChemInform Abstract: Lithiated MnO2 Phases as Cathodes for 3 V Li and Li-Ion Cells." ChemInform 28, nr 40 (3.08.2010): no. http://dx.doi.org/10.1002/chin.199740018.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

Artykuły w czasopismach na temat „Li-Chin”

Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych