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Artykuły w czasopismach na temat "Larves de poisson zèbre"
Ryckebüsch, Lucile. "Le poisson zèbre". médecine/sciences 31, nr 10 (październik 2015): 912–19. http://dx.doi.org/10.1051/medsci/20153110018.
Pełny tekst źródłaVölkel, Pamela, Babara Dupret, Xuefen Le Bourhis i Pierre-Olivier Angrand. "Le modèle poisson zèbre dans la lutte contre le cancer". médecine/sciences 34, nr 4 (kwiecień 2018): 345–53. http://dx.doi.org/10.1051/medsci/20183404016.
Pełny tekst źródłaButor, Nicolas. "Le poisson-zèbre dort comme nous". Pour la Science N° 503 - septembre, nr 9 (9.01.2019): 12a. http://dx.doi.org/10.3917/pls.503.0012a.
Pełny tekst źródłaKahn, A. "Flash : Mutation à saturation chez le poisson zèbre". médecine/sciences 13, nr 1 (1997): 132. http://dx.doi.org/10.4267/10608/323.
Pełny tekst źródłaMarie-Hardy, Laura, Marc Khalifé, Lofti Slimani i Hugues Pascal-Moussellard. "Caractérisation scanographique rachidienne chez le poisson-zèbre : méthode". Revue de Chirurgie Orthopédique et Traumatologique 105, nr 2 (kwiecień 2019): 213–18. http://dx.doi.org/10.1016/j.rcot.2019.01.015.
Pełny tekst źródłaJouault, Thierry. "Avant-propos". médecine/sciences 35, nr 2 (luty 2019): 152. http://dx.doi.org/10.1051/medsci/2019011.
Pełny tekst źródłaSapede, Dora. "Migrations cellulaires : étudier le poisson-zèbre pour comprendre les métastases ?" médecine/sciences 19, nr 8-9 (sierpień 2003): 780–82. http://dx.doi.org/10.1051/medsci/20031989780.
Pełny tekst źródłaIdoux, Romane, Sandrine Bretaud, Christine Berthier, Vincent Jacquemond, Florence Ruggiero i Bruno Allard. "Étude physiopathologique de la myopathie de Bethlem à l’aide d’un modèle de poisson zèbre". médecine/sciences 35 (listopad 2019): 39–42. http://dx.doi.org/10.1051/medsci/2019182.
Pełny tekst źródłaEkker, M., i MA Akimenkko. "Le poisson zèbre (danio rerio), un modèle en biologie du développement". médecine/sciences 7, nr 6 (1991): 553. http://dx.doi.org/10.4267/10608/4405.
Pełny tekst źródłaDambly-Chaudière, Christine. "Imagerie et développement de la ligne latérale chez le Poisson-zèbre". Journal de la Société de Biologie 198, nr 2 (2004): 153–55. http://dx.doi.org/10.1051/jbio/2004198020153.
Pełny tekst źródłaRozprawy doktorskie na temat "Larves de poisson zèbre"
Poirier, Jasmine. "Segmentation de neurones pour imagerie calcique du poisson zèbre : des méthodes classiques à l'apprentissage profond". Master's thesis, Université Laval, 2019. http://hdl.handle.net/20.500.11794/36452.
Pełny tekst źródłaThe experimental study of the resilience of a complex network lies on our capacity to reproduceits structural and functional organization. Having chosen the neuronal network of the larvalzebrafish as our animal model for its transparency, we can use techniques such as light-sheet microscopy combined with calcium imaging to image its whole brain more than twice every second, with a cellular spatial resolution. Having both those spatial and temporal resolutions, we have to process and segment a great quantity of data, which can’t be done manually. Wethus have to resort to numerical techniques to segment the neurons and extract their activity. Three segmentation techniques have been compared : adaptive threshold (AT), random deci-sion forests (ML), and a pretrained deep convolutional neural network. While the adaptive threshold technique allow rapid identification and with almost no error of the more active neurons, it generates many more false negatives than the two other methods. On the contrary, the deep convolutional neural network method identify more neurons, but generates more false positives which can be filtered later in the proces. Using the F1 score as our comparison metrics, the neural network (F1= 59,2%) out performs the adaptive threshold (F1= 25,4%) and random decision forests (F1= 48,8%). Even though the performances seem lower compared to results generally shown for deep neural network, we are competitive with the best technique known to this day for neurons segmentation, which is 3dCNN (F1= 65.9%), an algorithm presented in the neurofinder challenge.
Jouary, Adrien. "Comportement moteur induit visuellement et spontané chez la larve du poisson zèbre". Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066605/document.
Pełny tekst źródłaBehavior is often conceived as resulting from a stimulus-response association. Under this paradigm, understanding the nervous system is reduced to finding the relation between a sensory input and a motor output. Yet, in naturally behaving animals, motor actions influence sensory perceptions just as much as the other way around. Animals are continuously relying on sensory feedback to adjust motor commands. On the other hand, behavior is not only induced by the sensory environment, but can be generated by the brain's rich internal dynamics. My goal is to understand the sensory-motor dialogue by monitoring large brain regions, yet, with a single-neuron resolution. To tackle this question, I have used zebrafish larva to study visually induced and internally driven motor behaviors. Zebrafish larvae have a small and transparent body. These features enable using large-scale optical methods, such as selective plane illumination microscopy (SPIM), to record brain dynamics. In order to study goal-driven navigation in conditions compatible with imaging, I developed a visual virtual reality system for zebrafish larva. The visual feedback can be chosen to be similar to what the animal experiences in natural conditions. Alternatively, alteration of the visual feedback can be used to study how the brain adapts to perturbations. For this purpose, I first generated a library of free-swimming behaviors from which I learned the relationship between the trajectory of the larva and the shape of its tail. I then use this technique to infer the intended displacements of head-fixed larvae. The visual environment was updated accordingly. In the virtual environment, larvae were capable of maintaining the proper speed and orientation in the presence of whole-field motion and produced fine changes in orientation and position required to capture virtual preys. I demonstrate the sensitivity of larvae to visual feedback by updating the visual world only after the discrete swimming episodes. This feedback perturbation induced a decay in the performance of prey capture behavior, suggesting that larva rely on real-time visual feedback during swimming. Behavior can also be induced by the internal dynamics of the brain. In the absence of salient sensory cues, zebrafish larva spontaneously produces stereotypical tail movements, similar to those produced during goal-driven navigation. After having developed a new method to classify tail movements, I analyzed the sequence of spontaneously generated tail movements. The latter switched between period of quasi-rhythmic activity and long episodes of rest. Moreover, consecutive movements were more similar when executed at short time intervals (~10s). In order to study the mechanisms responsible for the spontaneous decisions to move, I coupled SPIM to tail movement analysis. Using dimensionality reduction, I identified clusters of neurons predicting the direction of spontaneous turn movements but not their timings. This Preliminary result suggests that distinct pathways could be responsible for the timing (when) and the selection (what) of spontaneous actions. Together, the results shed light on the role of feedback and internal dynamics in shaping behaviors and open the avenue for investigating complex sensorimotor process in simple systems
Yedji, Rodrigue. "Perturbateurs endocriniens de type phtalate et poisson zèbre Danio rerio : approche chémoprotéomique pour l'identification des cibles et recherche de signatures d'exposition". Electronic Thesis or Diss., Université de Lorraine, 2022. http://www.theses.fr/2022LORR0106.
Pełny tekst źródłaPhthalate esters are a family of synthetic compounds widely used as plasticisers. They are used in a number of plastic products such as packaging, toys, cosmetics, plastic roofing system and furniture decoration materials. Phthalates are not covalently bonded to the polymer matrix and are therefore easily released into the environment, resulting in animal and human exposure. In the absence of non-toxic substitutes, phthalate compounds are still widely used in industry, despite the classification of some of them by the European Chemicals Agency (ECHA) as suspected toxic substances and as endocrine disruptors. In addition, they are carcinogenic and teratogenic. The deleterious effect of phthalate esters on organisms is established, but the multiple nature of the effects observed shows that the mechanisms of action of phthalates are only partially elucidated. We used two targeted proteomics approaches to shed light on the mechanisms of action of phthalate esters. Dibutyl phthalate (DBP) was used as a model phthalate and zebrafish (D. rerio) as a model organism. Using the first targeted proteomics approach, affinity-based protein profiling (AfBPP), the functional disruption of proteins by DBP with photoaffinity probes from aryl azide synthesis was demonstrated. Optimisation of the binding conditions for diazirine probes (Diazirine 2) should provide us with a probe that can be used to identify DBP protein targets in the zebrafish proteome. The second approach, activity-based protein profiling (ABPP), used a reactive probe specific for serine hydrolases (SHs) to map active SHs in the zebrafish proteome for the first time. The identification of deregulated SHs in the presence of DBP in zebrafish larvae was also reported in this study. Overall, our results indicate that targeted proteomics approaches such as ABPP or AfBPP can be an asset for understanding xenobiotic-related mechanisms of action in ecotoxicology
Olive, Raphaël. "Perception des écoulements et des vibrations chez la larve de poisson-zèbre : étude comportementale et imagerie". Thesis, Paris 6, 2015. http://www.theses.fr/2015PA066468/document.
Pełny tekst źródłaThe Zebrafish larva is a model for the study of vertebrate central nervous system. Mutants have been developped which express calcium reporter (GCaMP) in their neurons. These mutants are used in functional imaging experiments in which the activity of almost all the neurons is simultaneously recorded. The first chapter of this thesis is devoted to the conception of a behavioral experiment designed to record and analyse the swim movements of zebrafish larvae submitted to a succion flow. The contributions of lateral line (specific fish organ responsible for the perception of hydrodynamic stimulations) and visual system have been separated in order to describe the interactions between those two modalities and their respective effects on larvae reactions to aspiration, analysed through their swim patterns. This experiment was thought to prepare a study of neuronal responses to aspiration, thanks to the laser sheet microscopy setup developped in the laboratory since four years. The aim was to use calcium imaging to work on cross-modal experiment, by the dynamic observation of neural networks dedicated to the two sensory modalities when stimulated simultaneously or separatly. Facing difficulties to record lateral line response using calcium imaging, which are not been recorded yet, functional imaging experiments have adressed zebrafish larvae auditory system instead of hydrodynamic perception. The second part of this thesis describes protocols, analysis and results from these experiments. The results are still at an exploratoty stage but draw a scheme of neural networks involved in vibrations perception in zebrafish larvae : they present recordings of a huge part of central nervous system and the activity evoked by auditory stimulations
Perrichon, Prescilla. "Développement de tests embryonnaires prédictifs d’effets toxiques précoces et tardifs pour des molécules hydrophobes". Thesis, La Rochelle, 2014. http://www.theses.fr/2014LAROS040/document.
Pełny tekst źródłaPAHs are ubiquitous widespread contaminants which emissions are overgrowing with increasing anthropogenic activities. These semi-persistent chemicals are threatening organisms in the environment. Ecosystems health and resilience are essential to life and societal functioning. Impact assessment of these chemicals is a real requirement for society thereby establishing the european legislative (DCE, Water Framework Directive) and regulations (REACH, Registration, Evaluation, Authorisation and Restriction of Chemicals) for better (eco)toxicological risk management. In this context, many bioassays have been developed to assess environmental quality, the toxicity of chemicals (including mixture) on organisms and its underlying mechanisms. This study aimed to identify (eco)toxicological risks in the context of fish embryo-larval assay, using a relevant and well-known model : the zebrafish Danio rerio. Two complementary approaches (chemical and biological) were used to assess transfer, fate and toxicity of PAHs. Induced-responses were evaluated at different levels of biological organization, from molecular (oxidative stress, DNA damage, EROD) to physiological (cardiac activity), behavioral (PhotoMotor Response) and morphological levels. Among the three exposure routes tested, the sediment contact exposure was not suitable for PAHs toxicity assessment. In contrast, exposures to water-accommodated fractions (WAF) of petroleum products represented a more reproducible, sensitive and integrative approach for testing multiscale toxic effects. Following these experiments, the observation scope of induced effects should be broadened beyond the standard duration recommended by the Organization for Economic Cooperation and Development in order not to underestimate the acute effect of the tested-compounds. Furthermore, our multigenerational study showed physiological and behavioral disturbances on the first generation of offspring providing from parents exposed to contaminated-food with three aromatic extracts pyrolytic and petrogenic origin (heavy and light). Although the contamination transfer of PAHs has not been revealed, the observed alterations (probably due to a transfer through genetic and epigenetic modifications) in the early stages of zebrafish could have adverse effects on survival and recruitment populations. Multigenerational studies prove to be an integrated approach for the toxicity assessment of chemicals and strengthen the predictive effects. These ecotoxicological studies should be widely undertaken to evaluate the potential for exposed-population to maintain in the future time
Terras, Fériel. "Développement d’une méthode de mesure et d’analyse du transport intraneuronal dans le cerveau de larve de poissons-zèbre par suivi de nanocristaux non-linéaires en microscopie de second-harmonique : application à l’étude d’anomalies de transport chez des poissons portant une mutation retrouvée dans des neuropathies humaines". Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASP050.
Pełny tekst źródłaMolecular transport in neurons plays an essential role in their development and the maintenance of their functions, due in particular to their long branches. The consequences of axonal transport abnormalities have long been associated with Alzheimer's disease, such as the swelling of axons caused by the accumulation of transported organelles. However, there are few tools allowing the detailed long-term study of this transport in culture and even less in vivo.The team in which this work was conducted has developed a method for measuring intraneuronal transport in mouse cultured neurons based on the tracking of endosomes having spontaneously internalized fluorescent nanodiamonds. This technique was able to detect genetic risk factors of neuropsychiatric diseases, proving its high sensitivity.The objective of my thesis was to extend this measurement method to the neuronal circuit of the zebrafish larvae’s brain. For this purpose, I have used nanocrystals (NCs) with non-linear optical response, which can be excited in a tissue transparency window at a wavelength ≈1 µm, and generate a second harmonic signal. We have used the multiphoton microscope of the Emerg'In facility (INRAE, Jouy-en-Josas), which is installed next to a fish farming and has resonant galvanometric scanners and hybrid detectors, which allowed us to maintain a frame rate of 20 fps despite the need to scan the laser beam, unlike in culture studies conducted in wide field.We have developed a new measurement protocol, from the injection of the NC to the extraction of transport parameters from the videos data. To do this, I have optimized and automated the data analysis by developing two programs written in Python: one that automatically reconstructs the trajectories of the NCs as faithfully as possible and the other that segments the trajectories into motion and pause phases in order to extract transport parameters.I have applied these new tools to study, in a transgenic zebrafish model, the functional impact of a mutation present in neuropathies including hereditary spastic paraplegia and peripheral Charcot-Marie-Tooth disease. In patients suffering from one of these diseases, several mutations have been identified in the KIF5A gene coding for the heavy chain of the kinesin 1 molecular motor which ensures anterograde movements (from the cell body to the periphery). We have measured endosome transport in axons of neurons in the brain of transgenic zebrafish larvae bearing a mutation on kif5a, and we observed subtle changes in this transport. More than 500 endosome trajectories (acquired at a depth of ≈100 µm below the surface of the head) were analyzed from 40 larvae.As a control, we also studied endosomal transport in mutants deprived of dynein motors, the only ones to ensure retrograde transport, and observed that bi-directional transport was totally stopped in the mutants.This methodology can be used to screen for functional abnormalities resulting from genetic factors of neurological or neurodegenerative disorders
Bertrand, Christelle. "L' acétylcholinestérase du poisson zèbre, "Danio rerio"". Montpellier 2, 2000. http://www.theses.fr/2000MON20188.
Pełny tekst źródłaPruvot, Benoist. "Développement de modèles de cancer par xénotransplantation chez le poisson zèbre". Dijon, 2009. http://www.theses.fr/2009DIJOS065.
Pełny tekst źródłaNew cancer model development allowed new approach to understand important mechanisms involved in tumour progression and to develop new treatments. Due to its advantages, such as embryos transparency, zebrafish (Danio rerio) is more and more used in biological experimentation, and recently in cancer research. By transplanting mammalian tumour cells in zebrafish larvae, several models have been obtained. Such models allowed cancer cells development and response to several treatment , considering cancer cells and tumour interactions. We developed leukaemia models based on human cell lines transplantations. We also validated our models in pharmacological assays. Another model was obtain by injecting human leukaemia primary cells extract from patient blood and allowed us to define leukaemia cell fraction that can colonize zebrafish larvae. Nitric oxide (NO) involvement during tumour progression is ambivalent and still discussed. We developed a new in vivo model to analyse nitric oxide production and roles in tumour environment by using diaminofluorophores in a rat glioma xenograft model. By following tumour cell in vivo, we are able to study proteins that may be involved in tumour progression. We characterized a protein family called nonaspanins
Campario, Hugo. "Rôle du facteur de transcription hsf1 dans l’érythropoïèse du poisson zèbre". Thesis, Bourgogne Franche-Comté, 2020. http://www.theses.fr/2020UBFCI004.
Pełny tekst źródłaHeat shock proteins (HSPs) are reported to play an important role in erythropoiesis. The expression of HSP genes is mainly controlled by Heat shock factor 1 (HSF1), a highly conserved transcription factor. So far, a detailed understanding of the function of HSF1 in erythropoiesis remains uncharacterized. This study has employed zebrafish as a relevant model to investigate the role of Hsf1 during embryonic erythropoiesis. We established hsf1-disrupted zebrafish lines using the CRISPR/Cas9 technology and performed phenotypic analyses throughout embryogenesis. We found that Hsf1 deficient embryos had a decreased number of primitive erythrocytes, while erythrocyte number in adults was unchanged. In Hsf1 deficient embryos, expression of embryonic a and b-globin genes was reduced as well as gata1 expression. In addition, the morphology of erythrocytes suggested an inhibition of erythrocyte maturation. On the other hand, no significant changes were observed in myeloid cells.Altogether our results support a key role for Hsf1 in erythrocyte maturation in vivo
Heuzé, Aurélie. "Processus régénératifs du cerveau moyen dorsal chez le poisson zèbre adulte". Thesis, Université Paris-Saclay (ComUE), 2017. http://www.theses.fr/2017SACLS508/document.
Pełny tekst źródłaUnlike mammals, the adult teleost brain exhibits widespread neurogenic activity and can regenerate after injury. The adult zebrafish has the capacity to regenerate neurons from constitutive or latent progenitors. During my PhD, I studied the neuronal regeneration in the zebrafish dorsal midbrain (optic tectum, OT). At adult stage, neuroepithelial-like progenitors at the OT periphery contribute to neuronal and glial lineages during homeostasis.I identified a putative enhancer of meis2a, which allowed me to trace the progeny of neuroepithelial-like progenitors. In a non-regenerative context I showed that enhancer-targeted progenitors were at the origin of the whole structure during development and of its continued neurogenesis during post-embryonic growth.Following lesion, OT displayed reactive neurogenesis, at larval and adult stages, nevertheless its topographical structure remained altered. In adults, I showed that both constitutive neuroepithelial-like progenitors and latent ependymoglial progenitors were activated in a regenerative context
Książki na temat "Larves de poisson zèbre"
Essai n° 250: Détection sur des embryons de poisson-zèbre transgénique tg(cyp19a1b:GFP) des perturbateurs endocriniens agissant via les récepteurs des œstrogènes (essai EASZY). OECD, 2021. http://dx.doi.org/10.1787/cf5871be-fr.
Pełny tekst źródłaCzęści książek na temat "Larves de poisson zèbre"
Wolpert, Lewis, Cheryll Tickle, Alfonso Martinez Arias, Peter Lawrence, Andrew Lumsden, Elizabeth Robertson i Jim Smith. "4. Développement des vertébrés II : xénope et poisson-zèbre". W Biologie du développement, 144–84. Dunod, 2017. http://dx.doi.org/10.3917/dunod.wolpe.2017.01.0144.
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