Gotowe bibliografie tematyczne / Lamines de type A

Gotowa bibliografia na temat „Lamines de type A”

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Data publikacji: 25 maja 2024

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Artykuły w czasopismach na temat "Lamines de type A"

Zinn-Justin, Sophie. "Maladies génétiques et lamines de type A : apport de la biologie structurale". médecine/sciences 18, nr 11 (listopad 2002): 1054–56. http://dx.doi.org/10.1051/medsci/200218111054.

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Zhang, Xue Yi, Guang Ping Zou i Li Hong Yang. "Mechanical Properties and Damage Mechanism of Glass Fiber Composite Laminates in Compression". Key Engineering Materials 417-418 (październik 2009): 609–12. http://dx.doi.org/10.4028/www.scientific.net/kem.417-418.609.

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Application of composite laminates was very wide in aerospace engineering, civil engineering, wind energy, auto industry, etc. Low cost glass fiber textile was often applied into composite laminates by many composites companies. It is of import that investigation of mechanical properties and damage mechanism of this composites laminates. Two types of composite laminates were studied in this paper. One type of composite laminates was made of glass fiber biaxial cloth. The other was made of glass fiber composite felt. Each type composite laminates has different direction aligned. Many specimen were tested in compression with universal testing materials machine model INSTRON 5500R. Strength of composite laminates and stress-strain diagram was obtained in these experiments. Effect of fiber different orientation on compression strength of laminates was found. Shear stresses between two laminas were calculated. Fracture mechanism of composites laminates was analyzed by macro-method. Fractography of laminates was applied into analysis of mechanism. SEM photo was acquired and observed in detail. The result is that strength and failure mechanism of different types composite laminates varied with fiber orientation and different textiles.

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Genty, Dominique, Andy Baker i William Barnes. "Comparaison entre les lamines luminescentes et les lamines visibles annuelles de stalagmites". Comptes Rendus de l'Académie des Sciences - Series IIA - Earth and Planetary Science 325, nr 3 (sierpień 1997): 193–200. http://dx.doi.org/10.1016/s1251-8050(97)88288-2.

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Dionne*, Jean-Claude. "Événements holocènes mis en évidence dans une coupe de la terrasse Mitis à l’embouchure de la rivière Fouquette, sur la rive sud du moyen estuaire du Saint-Laurent". Géographie physique et Quaternaire 57, nr 2-3 (22.09.2005): 241–47. http://dx.doi.org/10.7202/011317ar.

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Résumé Près de l’embouchure de la rivière Fouquette, une coupe d’environ 6 m de hauteur comprend trois unités lithostratigraphiques. Celle à la base (entre 3 et 6 m) est de type rythmique. Elle est composée de couches d’argile gris pâle, plastique et calcaire, et de lamines de sable interstratifiées. Le faciès de cette unité s’apparente à celui des dépôts tidaux de milieu estuarien relativement peu profond (10-15 m) correspondant en l’occurrence à un large chenal empruntant une dépression entre deux crêtes rocheuses appalachiennes. Des débris organiques ligneux récoltés à divers niveaux ont donné des âges au 14C compris entre 8,7 et 10,6 ka BP, ce qui correspond à une mise en place vers la fin de l’épisode de la Mer de Goldthwait, sur la rive sud de l’estuaire du Saint-Laurent. De 2 m d’épaisseur, l’unité 2 est composée de lits minces de limon et de sable fin gris pâle mis en place dans un milieu infratidal à intertidal inférieur. Elle n’a pas été datée. En surface, l’unité 3, d’environ 100 cm d’épaisseur, est sableuse. Elle a probablement été mise en place lors de l’épisode de Mitis dont l’âge moyen est de 2 ka BP. La coupe de la rivière Fouquette révèle une fois de plus que la nature de la terrasse de 6 m (terrasse Mitis) est parfois complexe ; elle peut être formée de dépôts variés mis en place antérieurement à l’épisode de Mitis ; elle confirme aussi que le niveau marin relatif était seulement d’une quinzaine de mètres supérieur au niveau actuel vers 9,5 ka BP.

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Hua, Ganlin, Songtao Wu, Jinyou Zhang, Rongchang Liu, Modi Guan, Yi Cai, Mengying Li i Surong Zhang. "Laminar Structure and Reservoir Quality of Shales with High Clay Mineral Content in the Qingshankou Formation, Songliao Basin". Energies 15, nr 17 (24.08.2022): 6132. http://dx.doi.org/10.3390/en15176132.

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This paper investigates high-maturity organic matter-rich shales with high clay mineral contents in the Qingshankou Formation, in the Gulong Depression of the Songliao Basin, at a sub-millimeter scale, using a new laminar division method based on XRF data. The influence of laminar structure on reservoir quality is examined using a combination of geochemistry, mineralogy, and pore structures. Explanatory models are established. Three types of laminar units are distinguished in the study area based on differences in pore structure. These are clay mineral laminae (UA), clay mineral-Ostracod laminae (UB), and clay mineral-felsic laminae (UC). UA has illite intergranular pores, micro-fractures, and organic pores, with diameters of 0.5~2 μm. UB primarily contains Ostracod shell margin fractures, pyrite intergranular pores, and chlorite intragranular pores. UC contains albite and illite intergranular pores. Nitrogen adsorption tests show that UA has the highest clay content and the best specific pore volume and specific surface area, indicating that clay minerals are the main contributors to the pores in this type of unit. 2D–3D models of different laminae reveal that carbonate cement is widely developed in UB and UC, but dissolution pores are less developed, with the result that the porosity of UA is two to three times greater than that of UB or UC. It appears that intergranular pores and fractures, formed during the transformation of clay minerals during the advanced thermal evolution stage, are the main contributors to storage space and flow channels. Thermal evolution, clay mineral transformation, and carbonate cementation are the key factors causing differences between laminar units. In addition, clay mineral laminae (UA) are the most important laminar units for shale oil enrichment in the study area. This finding is of great significance for accurately predicting the distribution of shale “sweet spots” and guiding shale oil and gas exploration.

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Lilina, Anastasia V., Anastasia A. Chernyatina, Dmytro Guzenko i Sergei V. Strelkov. "Lateral A11 type tetramerization in lamins". Journal of Structural Biology 209, nr 1 (styczeń 2020): 107404. http://dx.doi.org/10.1016/j.jsb.2019.10.006.

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Navarro, Claire L., Yannick Poitelon i Nicolas Lévy. "Lamines A et syndromes progéroïdes". médecine/sciences 24, nr 10 (październik 2008): 833–40. http://dx.doi.org/10.1051/medsci/20082410833.

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Steen, Rikke L., i Philippe Collas. "Mistargeting of B-Type Lamins at the End of Mitosis". Journal of Cell Biology 153, nr 3 (30.04.2001): 621–26. http://dx.doi.org/10.1083/jcb.153.3.621.

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We previously showed that targeting of protein phosphatase 1 (PP1) to the nuclear envelope (NE) by the A-kinase anchoring protein, AKAP149, correlates with nuclear assembly of B-type lamins in vitro. We demonstrate here that failure of AKAP149-mediated assembly of B-type lamins into the nuclear lamina at the end of mitosis is followed by apoptosis, and induces expression of the gene encoding A-type lamins in cells that normally do not express lamins A/C. In HeLa cells, inhibition of PP1 association with the NE mediated by a peptide containing the PP1-binding domain of AKAP149 results in failure of B-type lamins to assemble, and in their rapid caspase-dependent proteolysis. However, assembly of lamins A/C is not affected. Nonetheless, apoptosis follows within hours of nuclear reformation after mitosis. In lymphoid KE37 cells, which do not express lamins A/C, inhibition of B-type lamin assembly triggers rapid synthesis and nuclear assembly of both lamins A and C before apoptosis takes place. The results indicate that nuclear assembly of B-type lamins is essential for cell survival. They also suggest that mistargeting of B-type lamins at the end of mitosis elicits a tentative rescue process to assemble a nuclear lamina in lymphoid cells that normally do not express lamins A/C.

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Hanif, Mubashir, Ylva Rosengardten, Hanna Sagelius, Björn Rozell i Maria Eriksson. "Differential Expression of A-Type and B-Type Lamins during Hair Cycling". PLoS ONE 4, nr 1 (5.01.2009): e4114. http://dx.doi.org/10.1371/journal.pone.0004114.

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Hutchison, Chris J., i Howard J. Worman. "A-type lamins: Guardians of the soma?" Nature Cell Biology 6, nr 11 (listopad 2004): 1062–67. http://dx.doi.org/10.1038/ncb1104-1062.

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Rozprawy doktorskie na temat "Lamines de type A"

Jabre, Saline. "Impact of mechanical stress on nucleus morphology and transcription on skeletal muscle". Electronic Thesis or Diss., Sorbonne université, 2022. http://www.theses.fr/2022SORUS561.

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La réponse du noyau aux contraintes mécaniques impliquent les lamines de type A mais aussi la chromatine et les modifications post-traductionnelles des histones. Cette réponse est essentielle à l’adaptation des cellules aux contraintes mécaniques, notamment dans les tissus soumis à des contraintes mécaniques importantes comme le muscle squelettique. Cependant les mécanismes impliqués restent mal connus. Le premier objectif de ma thèse était de déterminer l'impact de la différenciation musculaire sur les caractéristiques nucléaires de cellules musculaires. Les objectifs suivants étaient d’analyser l’effet de l’expression des protéines de l'enveloppe nucléaire (lamines A/C, SUN1 et SUN2) et de la compaction de la chromatine sur la réponse nucléaire aux contraintes mécaniques. J’ai caractérisé la forme nucléaire et des marqueurs d’histone dans des cellules précurseurs musculaires (MuSC) immortalisées obtenus chez des patients sains et dans des myotubes (72h de différenciation). Les marqueurs d’histones suivants ont été analysés : 1-La tri-méthylation de la lysine4 de l'histone H3 (H3K4me3) et l'acétylation de H3K4 (H3K4ac), associés aux gènes activement transcrits 2- H3K27me3, un marqueur de l'hétérochromatine facultative, régulé par le développement 3- et H3K9me3, un marqueur de l'hétérochromatine constitutive. La différenciation en myotubes est associée à une élongation et à une réduction significative du volume nucléaire. De plus, l'intensité du marquage nucléaire H3K27me3 est significativement plus faible dans les myotubes par rapport aux MuSC alors que les intensités nucléaires H3K9me3 et H3K4me3 sont plus élevées. Ces résultats sont compatibles avec les modifications attendues de l'accessibilité de la machinerie transcriptionnelle avec la différenciation myogénique. Dans les myotubes, la déficience en lamines A/C entraîne une déformation nucléaire qui est majorée par le stretch mécanique (étirement cyclique de 10%, 4h) Le stretch est associé à une augmentation significative du volume nucléaire dans les myotubes témoins, qui est abolie dans les myotubes déficients en lamines A/C. Dans les myotubes témoins, le stretch augmente l'intensité du marquage H3K27me3 et réduit l'intensité du marquage H3K4me3 et H3K4ac. Dans les myotubes déficients en lamines A/C, l’intensité des marqueurs actifs de la chromatine est plus élevée en conditions statiques et stretch s’accompagne d’une augmentation paradoxale de H3K4me3 après. L’inhibition spécifique des histones désacétylases de classe I et II par la trichostatine A induit également une augmentation de H3K4ac en conditions statique et après stretch par rapport au myotubes témoins. A l’inverse, dans les myotubes déficients en SUN2 ou SUN1, l'étirement réduit l'intensité de H3K4me3, alors que l'augmentation de l'intensité nucléaire de H3K27me3 est abolie dans les myotubes déficients en SUN2 étirés. Par ailleurs, la déficience en lamines A/C s’accompagne d’une dérégulation majeure des gènes régulant les marqueurs d’histone. Dans l'ensemble, notre étude met en évidence des modifications importantes des marqueurs post-traductionnels des histones au cours de la différenciation musculaire et lors d'un stress mécanique. Les lamines de type A semblent cruciales pour prévenir l'activation anormale des marqueurs actifs de la chromatine dans les myotubes soumis à un défi mécanique. Nos résultats suggèrent que la mécano-réponse chromatinienne est étroitement régulée par les protéines de l'enveloppe nucléaire dans le muscle squelettique
The lamina, and specifically A-type lamins, are major contributors to nuclear stiffness and deformations. However, chromatin and its histone modification states also contribute to nuclear mechanics independently of A-type lamins. How A-type lamins and chromatin-mediated mechanoresponse contribute to mechanical load-mediated adaptation in normal and pathological skeletal muscle remains unknown. We sought to determine how muscle differentiation impacts nuclear characteristics in muscle cell precursors (MuSCs) and myotubes. Then, we investigated the respective roles of nuclear envelope proteins (lamin A/C, SUN1 and SUN2) and drug-modulated chromatin compaction on the mechanical load-mediated nuclear response in myonuclei. We used immortalized MuSCs obtained from healthy patients and analyzed nuclear shape and chromatin characteristics in MuSCs and myotubes obtained after 72h of differentiation. Histone modifications were analyzed: a) histone H3 lysine4 tri-methylation (H3K4me3) and H3K4 acetylation (H3K4ac), associated with transcriptionally active genes, b) H3K27 tri-methylation (H3K27me3), a chromatin repression marker, associated with facultative heterochromatin and c) H3K9 tri-methylation (H3K9me3), a chromatin repression marker associated with constitutive heterochromatin and mainly located at the nuclear periphery. Myotube differentiation was associated with nuclear elongation and significant reduction in nuclear volume. In addition, the relative intensity of nuclear H3K27me3 (chromatin repression marker) labelling was significantly lower in myotubes compared to MuSCs, whereas nuclear H3K9me3 and H3K4me3 (chromatin active marker) intensities were higher in myotubes compared to MuSCs, thereby showing that myogenic differentiation is modulating the accessibility of the transcriptional machinery. Myotubes were silenced for LMNA expression with silencing mRNA strategies and submitted to a cyclic stretch (10%,4hours) to investigate A-type lamin’ roles in nuclear shape and chromatin organization during mechanical stress. A-type lamin deficient myotubes had abnormal nuclear shape in static conditions and nuclear deformations further increased after cyclic stretch. Cyclic stretch was associated with a significant increase in nuclear volume in control myotubes that was abolished in A-type lamin deficient myotubes. In addition, stretching increased the intensity of the H3K27me3 and reduced H3K4me3 and H3K4ac intensities of labelling in nuclei from control myotubes. Importantly, A-type lamin deficiency was associated with higher intensity in chromatin active markers at baseline and a paradoxical increased in H3K4me3 after stretch. Consistent modifications in histone modifications were obtained by western-blots in control and A-type deficient myotubes. Interesting, stretch reduced H3K4me3 intensity both in SUN2 or SUN1-deficient myotubes while the increase in the nuclear intensity of the H3K27me3 was abolished in stretched SUN2-deficient myotubes. Transcriptomic changes associated with A-type lamin deficiency support these results. Trichostatin A (TSA) is a powerful and specific Class I and II histone deacetylase inhibitor (HDACi), widely used to increase the expression of genes silenced by chromatin condensation, thereby favoring chromatin decompaction. TSA increased nuclear volume without affecting nuclear shape both in static and stretched conditions. In addition, TSA decreased H3K27me3 and H3K9me3 intensities in static myotubes but did not prevent the stretch-induced increase in H3K27me3 intensity. Overall, our study highlights crucial changes of histone post-translational markers during muscle differentiation and upon mechanical challenge. A-type lamins appear crucial to prevent abnormal activation of chromatin active markers in mechanically challenged myotubes. Moreover, our results suggest that the nuclear mechano-response is tightly regulated by nuclear envelope proteins in skeletal muscle

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DeLoyht, Jacqueline M. "The Role Of A Type Lamins In Regulating Myelination". VCU Scholars Compass, 2018. https://scholarscompass.vcu.edu/etd/5388.

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Multiple sclerosis (MS), a demyelinating disorder of the central nervous system (CNS), affects approximately 400,000 individuals in the United States, and 2.5 million people worldwide. It is a leading cause of disability in young adults. Current treatments for MS target the inflammatory aspects of the disease, but do not aid in remyelination. To address remyelination as a therapeutic strategy, it is imperative to identify mechanisms that regulate myelin formation, including epigenetic targets. In this study, we investigate the role of the LMNA, a gene encoding Lamins A and C, intermediate filaments of the nuclear lamina, in regulating oligodendrocyte development and myelination in the CNS. Using electron microscopic analyses, I examined levels of heterochromatin and its distribution in the oligodendrocyte nucleus as an indicator of gene expression, oligodendrocyte maturity, and myelin formation in the absence of A type lamins.. While overall levels of heterochromatin in oligodendrocytes were not altered in the absence of A type lamins, peripherally located heterochromatin was reduced and thinner myelin was observed in the spinal cord. My observations present novel findings for the role of LMNA in oligodendrocytes and myelination.

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Poitelon, Yannick. "Explorations de modèles animaux et cellulaires de la maladie de Charcot-Marie-Tooth de type AR-CMT2A". Aix-Marseille 2, 2009. http://www.theses.fr/2009AIX20710.

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Woerner, Stéphanie. "Interaction entre les lamines de type A sauvages ou mutées et le facteur de transcription SREBP1 : caractérisation et impact sur la liaison de SREBP1 à l'ADN". Paris 7, 2011. http://www.theses.fr/2011PA077016.

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Les lamines de type A (prélamine A, lamines A et C) sont des protéines nucléaires codées par le gène LMNA. Elles jouent un rôle dans la structure du noyau et dans la régulation de l'expression de gènes grâce à leur capacité à interagir avec divers partenaires. Nous avons caractérisé l'interaction des lamines A/C avec le facteur de transcription SREBP1 (Sterol Regulatory Elément Binding Protein 1) impliqué dans la différenciation adipocytaire, afin d'élucider le mécanisme par lequel SREBP1 serait inactivé dans les lipodystrophies causées par des mutations du gène LMNA. Les tests de pull-down réalisés avec des domaines protéiques purifiés ont montré qu'/w vitro i) le domaine 227-487 de SREBP1, qui inclut les régions de liaison à l'ADN et de dimérisation (bHLH-zip), interagit avec un domaine de la région carboxyl-terminale des lamines qui est commun à la prélamine A et aux lamines A/C; et ii) les lamines mutées R482W et R453 W, responsables de lipodystrophie (FPLD) et de dystrophie musculaire (AD-EDMD), présentent un gain d'interaction pour SREBP1. De plus, les tests de retard sur gel et de pull-down réalisés en présence d'ADN SRE (Sterol Response Elément) suggèrent i) un chevauchement des sites d'interaction pour les lamines et l'ADN au sein du domaine 227-487 de SREBP1, et ii) une interaction préférentielle de SREBP1 avec l'ADN plutôt qu'avec les lamines, en raison de constantes d'affinités différentes. Nos résultats suggèrent que dans les cellules de tissu adipeux dystrophique, SREBP1 serait séquestré par les lamines de type A avant d'avoir lié ses séquences d'ADN cibles, inhibant ainsi sa fonction de facteur de transcription
A-type lamins (prelamin A, lamins A and C) are nuclear proteins encoded by the LMNA gene. They play a role in the nuclear structure and in the regulation of gene expression due to their capacity to interact with many partners. We have characterized the interaction of A-type lamins with the transcription factor SREBP1 (Sterol Regulatory Element Binding Protein 1) involved in adipocyte differentiation, in order to elucidate the mechanisms by which SREBP1 would be inactivated in lipodystrophies caused by LMNA gene mutations. Pull-down assays performed with purified protein domains have shown that in vitro i) the domain 227-487 of SREBP1 that includes the DNA binding and the dimerization regions (bHLH-zip), interacts with a domain of the carboxyl-terminal region of lamins that is commun to prelamin A and lamins A/C; and ii) the R482W and R453W variants of lamins identified in lipodystrophy (FPLD) and muscular dystrophy (AD-EDMD) bound to SREBP1 227-487 with increased avidity. In addition, electrophoretic mobility shift assays and pull- down assays performed in the presence of SRE DNA(Sterol Response Element DNA) suggest i) an overlap of the interaction sites for lamins and DNA within the domain 227-487 of SREBP1 and ii) a preferential interaction of SREBP1 with DNA than with lamins, due to different affinity constants. Our results suggest that in cells of dystrophic adipose tissue, SREBP1 would be inactivated due to its sequestration by A-type lamins before reaching its target DNA sequences

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Parman-Ryans, Jaime L. "A-type Lamins in Cell Cycle Regulation". Digital Commons @ East Tennessee State University, 2017. https://dc.etsu.edu/etd/3240.

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Proteins of the nuclear lamina provide structural support to the nuclear envelope and participate in a variety of cellular functions, such as chromatin organization and transcriptional regulation. One of these proteins, Lamin A (72kDa), is synthesized as a 74 kDa precursor protein, Prelamin A, which undergoes an unusual maturation pathway that requires two farnesylation-dependent endoproteolytic cleavages. The second cleavage is unique to lamin A in higher vertebrates and is specifically carried out by the endoprotease zmpste24. Although most previous studies have focused mainly on the function of mature Lamin A, recent evidence from our laboratory shows important biological functions for Prelamin A as well. Prelamin A concentration in proliferating cells is very low or undetectable. Conversely, during quiescence induced by mitogen withdrawal or contact inhibition, Prelamin A levels increase dramatically. These variations are directly regulated by changes in expression and enzymatic activity of zmpste24. The central hypothesis of this dissertation is that full-length farnesylated and carboxymethylated prelamin A (FC-PreA) antagonizes both proliferation and apoptosis, therefore playing a role in cellular quiescence/senescence. To accomplish this goal, we studied the transcriptional regulation of zmpste24 and the interaction of FC-preA with proteins that participate in cell cycle control. 1) We identified and characterized a functional site for the E2F1 transcription factor (involved in the control of cell cycle) in the proximal 5’ UTR region of zmpste24. 2) By using proximity-labeling and co-immunoprecipitation-mass spectrometry techniques, we identified a set of proteins that interact preferentially with L467R-Prelamin A (uncleavable mutant) but not with mature Lamin A. Many of these proteins function to regulate progression through cell cycle.

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Perrin, Sophie. "Vieillissement, infection par le VIH-1 & traitements antirétroviraux". Thesis, Aix-Marseille, 2012. http://www.theses.fr/2012AIXM5058.

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L'utilisation des antirétroviraux (ART) a permis une augmentation de la durée des patients infectés par le VIH. Par ailleurs, les comorbidités, retrouvées au cours du vieillissement physiologique, semblent être plus fréquentes et d'apparition plus précoce ce qui pourrait suggérer une modification du programme de vieillissement chez ces patients. L'étude ANRS EP45 « Aging » (clinicalTrials.gov, NCT01038999) a pour objectif d'analyser chez des patients infectés par le VIH traités ou non les mécanismes cellulaires connus pour être impliqués dans le vieillissement. Les PBMC d'une cohorte de 130 patients infectés par le VIH 1 appariés en âge et en sexe avec 49 sujets séronégatifs ont été analysés. Trois centres spécialisés (Marseille, Montpellier, Nice) ont recruté des patients infectés naïfs ou sous première ligne de traitement. Les résultats présentés dans ce manuscrit rapportent l'analyse des mitochondries et des lamines nucléaires. La maturation de la lamine A ne semble pas modifiée dans les PBMC de patients sous traitement contenant un inhibiteur de protéase. Cependant, ces cellules pourraient ne pas être le modèle le plus adapté pour explorer ce volet. D'autre part, l'infection est responsable d'anomalies mitochondriales dans les lymphocytes, partiellement corrigées par les traitements antirétroviraux qui modifient les mitochondries des monocytes moins sensibles à l'infection. Bien que les secondes générations de ART soient moins toxiques que les premières, leurs effets secondaires pourraient néanmoins, sur « le long terme » et/ou généralisés à l'ensemble de l'organisme, être l'un des facteurs modifiant le programme de vieillissement de ces patients
Antiretroviral therapy (ART) has increased life expectancy in HIV-infected patients. Moreover, some age-related disorders were found to be more frequent in HIV infected and treated patients than in an age-matched general population, suggesting a modified time course of aging in HIV infected patients. The ANRS EP45 « Aging » study (clinicalTrials.gov, NCT01038999) investigated in PBMC from HIV-1 infected patients under treatment or not the cellular mechanisms known to be involved in aging. The study was performed on a cohort of 130 patients HIV-1 infected age- and sex-matched with 49 seronegative control subjects. Patients never treated with ART (naïve) or under first line were recruited by 3 AIDS centres (Marseille, Montpellier, Nice). Results presented here describe explorations of mitochondria and nuclear lamin. No alteration of lamin A maturation was detected in PBMC from HIV-1 infected patients under treatment with protease inhibitor. However, these cells could not be the most appropriate models to investigate lamin A-related aging pathway. On another hand, mitochondrial modifications were observed in lymphocytes from HIV infected naive patients. These alterations were only partly rescued by ART whereas its induced slight changes in monocytes that appeared to be less sensitive to infection. While second generation of ART are less toxic than the first one, their secondary effects, due to long term exposure and/or generalised to different tissues, could lead to a modified time course of aging in HIV infected patients

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Lau, Chong Chuan. "A fracture mechanics approach to the adhesion of packaging laminates". Thesis, Imperial College London, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296356.

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Ylikärppä, R. (Ritva). "Type XVIII and XV collagens: primary structure of human alpha1(XVIII) chain, phenotypic studies of type XVIII collagen single null and type XVIII and XV collagen double null mice". Doctoral thesis, University of Oulu, 2003. http://urn.fi/urn:isbn:9514271416.

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Abstract In this thesis study, the primary structure of the human α1(XVIII) polypeptide was elucidated, its tissue distribution was studied, and the phenotypic changes in the mouse eye due to lack of type XVIII collagen in a knock-out mouse model were studied further. In addition, the consequences of simultaneous lack of both type XVIII and XV collagen were studied in a mouse model lacking both of these proteins. Two variant forms of human α1(XVIII) polypeptide were identified in this study, although, to date, a third form has also been characterized. The analysis of tissue distribution of the two polypeptide forms revealed differences in their tissue distribution, since the longest variant occurs prominently in the liver, while the short form is the major transcript in other tissues studied, e.g. in the kidney. The study of the type XVIII single null mouse eyes revealed abnormalities in the anterior eye segment in addition to the previously reported defects in the posterior eye part. In the type XVIII single null mice the iris was fragmented, pigment deposits could be seen in the pupil, and the pupillary ruff in the edge of a normal mouse iris was missing in these mice. The ciliary body was also abnormal, since the ciliary processes start to show regression in adult animals and eventually the basal infoldings of the non-pigmented ciliary body epithelia become flattened in the null mice. The intraocular pressure stabilizes to a lower level in adult mutant mice compared to controls, most likely reflecting the atrophied ciliary epithelia. The BM zones were also defective in the type XVIII null mouse eyes. The absence of an immunosignal with one of the antibodies detecting laminin γ2 chain in the type XVIII null mouse eyes may implicate conformational changes in the laminin γ2 chain due to lack of type XVIII collagen, and subsequently interaction between type XVIII collagen and laminin γ2 chain in normal mouse eye BMs. The study of the type XVIII and XV double null mice revealed that these mice were viable and fertile and had no major additional abnormalities compared to both single null mice. However, the regression of hyaloid capillaries (vasa hyaloidea propria, VHP) was studied in these mice, and a slight delay in the detachment of these vessels from the retina was noticed. Thus, the two collagens do not function entirely independently from each other. The studies with type XVIII collagen single null mice indicate that in addition to the posterior eye phenotype, this collagen is needed for the normal structural integrity of the anterior eye segment and basement membranes of the eye. The mouse model lacking both type XVIII and type XV collagen indicates that the roles of the two collagens are essentially diverse, although a slight compensatory effect was observed in the detachment of the hyaloid capillaries from the retina.

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Nitta, Ryan Takeo. "A-type lamins are necessary for the stabilization of the retinoblastoma protein /". Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/9209.

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Harryman, William L., Erika Pond, Parminder Singh, Andrew S. Little, Jennifer M. Eschbacher, Raymond B. Nagle i Anne E. Cress. "Laminin-binding integrin gene copy number alterations in distinct epithelial-type cancers". E-CENTURY PUBLISHING CORP, 2016. http://hdl.handle.net/10150/615112.

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The laminin-binding integrin (LBI) family are cell adhesion molecules that are essential for invasion and metastasis of human epithelial cancers and cell adhesion mediated drug resistance. We investigated whether copy number alteration (CNA) or mutations of a five-gene signature (ITGB4, ITGA3, LAMB3, PLEC, and SYNE3), representing essential genes for LBI adhesion, would correlate with patient outcomes within human epithelial-type tumor data sets currently available in an open access format.

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Książki na temat "Lamines de type A"

Braslow, Albert L. A history of suction-type laminar-flow control with empahsis [i.e. emphasis] on flight research. Washington, D.C: NASA History Division, Office of Policy and Plans, NASA Headquarters, 1999.

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Braslow, Albert L. A history of suction-type laminar-flow control with emphasis on flight research. Washington, DC: NASA History Office, Office of Policy and Plans, NASA Headquarters, 1999.

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Braslow, Albert L. A history of suction-type laminar-flow control with emphasis on flight research. Washington, DC: NASA History Office, Office of Policy and Plans, NASA Headquarters, 1999.

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Braslow, Albert L. A history of suction-type laminar-flow control with emphasis on flight research. Washington, DC: NASA History Office, Office of Policy and Plans, NASA Headquarters, 1999.

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Braslow, Albert L. A history of suction-type laminar-flow control with emphasis on flight research. Washington, DC: NASA History Office, Office of Policy and Plans, NASA Headquarters, 1999.

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Braslow, Albert L. A history of suction-type laminar-flow control with emphasis on flight research. Washington, DC: NASA History Office, Office of Policy and Plans, NASA Headquarters, 1999.

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Braslow, Albert L. A history of suction-type laminar-flow control with emphasis on flight research. Washington, DC: NASA History Office, Office of Policy and Plans, NASA Headquarters, 1999.

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Braslow, Albert L. A history of suction-type laminar-flow control with emphasis on flight research. Washington, DC: NASA History Office, Office of Policy and Plans, NASA Headquarters, 1999.

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Braslow, Albert L. A history of suction-type laminar-flow control with emphasis on flight research. Washington, DC: NASA History Office, Office of Policy and Plans, NASA Headquarters, 1999.

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Części książek na temat "Lamines de type A"

Vigouroux, Corinne, i Jacqueline Capeau. "A-Type Lamin-Linked Lipodystrophies". W Nuclear Organization in Development and Disease, 166–82. Chichester, UK: John Wiley & Sons, Ltd, 2008. http://dx.doi.org/10.1002/0470093765.ch11.

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Maslennikova, I. I. M., i M. B. Zelman. "On Subharmonic-Type Laminar Turbulent-Transition in Boundary Layer". W Laminar-Turbulent Transition, 21–28. Berlin, Heidelberg: Springer Berlin Heidelberg, 1985. http://dx.doi.org/10.1007/978-3-642-82462-3_3.

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Shang, Deyi. "Review of Falkner-Skan Type Transformation for Laminar Forced Convection Boundary Layer". W Theory of Heat Transfer with Forced Convection Film Flows, 39–49. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-12581-2_3.

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Henriksen, K., i M. A. Karsdal. "Type I Collagen". W Biochemistry of Collagens, Laminins and Elastin, 1–11. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-809847-9.00001-5.

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Gudmann, N. S., i M. A. Karsdal. "Type II Collagen". W Biochemistry of Collagens, Laminins and Elastin, 13–20. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-809847-9.00002-7.

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Nielsen, M. J., i M. A. Karsdal. "Type III Collagen". W Biochemistry of Collagens, Laminins and Elastin, 21–30. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-809847-9.00003-9.

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Sand, J. M. B., F. Genovese i M. A. Karsdal. "Type IV Collagen". W Biochemistry of Collagens, Laminins and Elastin, 31–41. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-809847-9.00004-0.

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Leeming, D. J., i M. A. Karsdal. "Type V Collagen". W Biochemistry of Collagens, Laminins and Elastin, 43–48. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-809847-9.00005-2.

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Sun, S., i M. A. Karsdal. "Type VI Collagen". W Biochemistry of Collagens, Laminins and Elastin, 49–55. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-809847-9.00006-4.

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Mortensen, J. H., i M. A. Karsdal. "Type VII Collagen". W Biochemistry of Collagens, Laminins and Elastin, 57–60. Elsevier, 2016. http://dx.doi.org/10.1016/b978-0-12-809847-9.00007-6.

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Streszczenia konferencji na temat "Lamines de type A"

Nishimura, Riki, Kenji Kawashima i Toshiharu Kagawa. "Analysis of laminar flow meter with flute-type cross section laminar elements". W 2008 Asia Simulation Conference - 7th International Conference on System Simulation and Scientific Computing (ICSC). IEEE, 2008. http://dx.doi.org/10.1109/asc-icsc.2008.4675531.

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Collazo Garcia, Armando R., i Phillip J. Ansell. "Evaluation of a Griffith Type Transonic Laminar Flow Airfoil". W 2018 Applied Aerodynamics Conference. Reston, Virginia: American Institute of Aeronautics and Astronautics, 2018. http://dx.doi.org/10.2514/6.2018-3177.

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Asanuma, Hiroshi. "Development of Active Laminates and Composites". W ASME 2006 International Mechanical Engineering Congress and Exposition. ASMEDC, 2006. http://dx.doi.org/10.1115/imece2006-14546.

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The present paper describes development of active laminates and composites proposed by Asanuma. The active laminates were successfully made by hot-pressing of an aluminum plate as a high CTE (Coefficient of Thermal Expansion) material, a unidirectional CFRP (Carbon Fiber Reinforced Plastics) prepreg as a low CTE material and an electric resistance heater, and a KFRP (Kevlar Fiber Reinforced Plastics) prepreg as a low CTE material and an insulator between them. Curvature of the active laminate linearly changes only in the fiber direction as a function of temperature, and it was made into complicated forms and their actuation performances were successfully demonstrated. As a high temperature type active laminate, three types of SiC/Al composites, that is, a laminate of continuous-fiber layer and unreinforced one, that of discontinuous-fiber layer and unreinforced one, and that of continuous-fiber layer and discontinuous-fiber one were fabricated, and it became clear that all of the composites curve unidirectionally in the fiber direction, and the curvatures reproducibly change during thermal cycles between room temperature and 813 K. Tensile strength of the combination type is higher than that of the continuous-fiber type, and its curvature exists between the continuous-fiber type and the discontinuous-fiber type.

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Van den Bulck, Prof Dr E., N. Erkens i Dr J. Declercq. "NUMERICAL INVESTIGATION OF LAMINAR NATURAL CONVECTION IN A FOIL TYPE TRANSFORMER". W CHT'97 - Advances in Computational Heat Transfer. Proceedings of the International Symposium. Connecticut: Begellhouse, 1997. http://dx.doi.org/10.1615/ichmt.1997.intsymliqtwophaseflowtranspphencht.430.

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Han, Jun, Satbir Singh i Eric Pomraning. "Assessment of Large-Eddy Simulation (LES) Models for Engine Type Flows: Effect of Model Type and Grid Size". W ASME 2013 Internal Combustion Engine Division Fall Technical Conference. American Society of Mechanical Engineers, 2013. http://dx.doi.org/10.1115/icef2013-19018.

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In this paper, large-eddy simulations (LES) of engine type flow are performed using commercially available computer code CONVERGE. First, accuracy of the numerical discretization scheme of the code is assessed using well established laminar flow configurations. Then, two different subgrid scale (SGS) models, an eddy-viscosity model of Vreman (Physics of fluids, 16, 2004) and a non eddy-viscosity model of Pomraning and Rutland (AIAA Journal, 40, 2002) are employed to predict turbulent flow characteristics in a piston-valve assembly. A number of grid resolutions are employed to perform the simulations, with and without the SGS models. The mean velocity and the root-mean-squared (RMS) values of the velocity fluctuations are compared with available experimental data. Although satisfactory comparison of model predictions with measured data is obtained, it is found that the predictions are more influenced by the grid resolution than the SGS model contribution.

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Bernhardt, M. L., G. Biscontin i C. O'Sullivan. "3D Discrete Element Method Simulations of a Laminar-Type Simple Shear Apparatus". W Geo-Congress 2014. Reston, VA: American Society of Civil Engineers, 2014. http://dx.doi.org/10.1061/9780784413272.059.

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Haans, Wouter, Hester Bijl, Marc Gerritsma i Bas Oudheusden. "Small Scale Flow Phenomena of Hole-Suction Type Laminar Flow Control Sailplanes". W 2nd AIAA Flow Control Conference. Reston, Virigina: American Institute of Aeronautics and Astronautics, 2004. http://dx.doi.org/10.2514/6.2004-2312.

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Ribeiro, Alexandre S., Nicholas S. Wren, Jonathan W. Jarvik i Kris N. Dahl. "The Expression of A-Type Lamins as a Regulator of Mechanics of the Nucleus and Cell Mechanotransduction". W ASME 2009 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2009. http://dx.doi.org/10.1115/sbc2009-206361.

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Mechanotransduction of extracellular stimuli into the chromatin located in the cell nucleus and overall cell mechanics may require the physical support of structures of A-type lamins. Several cellular pathologic phenotypes and phases of stem cell differentiation involve regulation and reorganization of A-type lamins. Here is presented a study of changes in cell mechanics associated to the reorganization of nuclear structures consequent to knockdown of A-type lamins. Transient dysmophism of the cell nucleus is observed during knockdown of A-type lamins, which seems to be driven by inner cellular forces resultant of cytoskeletal and chromatin structural reorganization.

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Khvostikov, Alexander, Andrey Krylov, Ilya Mikhailov, Pavel Malkov i Natalya Danilova. "Tissue Type Recognition in Whole Slide Histological Images". W 31th International Conference on Computer Graphics and Vision. Keldysh Institute of Applied Mathematics, 2021. http://dx.doi.org/10.20948/graphicon-2021-3027-496-507.

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Automatic layers recognition of the wall of the stomach and colon on whole slide images is an extremely urgent task in digital pathology as it can be used for automatic determining the depth of invasion of the digestive tract tumors. In this paper we propose a new CNN-based method of automatic tissue type recognition on whole slide histological images. We also describe an effective pipeline of training that uses 2 different training datasets. The proposed method of automatic tissue type recognition achieved 0.929 accuracy and 0.903 balanced accuracy on CRC-VAL-HE-7K dataset for 9-types classification and 0.98 accuracy and 0.926 balanced accuracy on the test subset of whole slide images from PATH-DT- MSU dataset for 5-types classification. The developed method makes it possible to classify the areas corresponding to the gastric own mucous glands in the lamina propria and also to distinguish the tubular structures of a highly differentiated gastric adenocarcinoma with normal glands.

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NISHIKAWA, MASAAKI, NAOKI MATSUDA i MASAKI HOJO. "Modeling of Multiple-Type, Multiple-Site Damage in Composite Laminates Using Peridynamics Theory". W American Society for Composites 2017. Lancaster, PA: DEStech Publications, Inc., 2017. http://dx.doi.org/10.12783/asc2017/15203.

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Raporty organizacyjne na temat "Lamines de type A"

Cook, K. V., R. A. Jr Cunningham, W. A. Jr Simpson i R. W. McClung. Ultrasonic detection of laminar-type defects in iridium alloy blanks. Office of Scientific and Technical Information (OSTI), lipiec 1986. http://dx.doi.org/10.2172/5422629.

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Hackett, Wesley, Michael Raviv, Anath Das, Oded Reuveni i Arie Gutman. Detecting Activity of Juvenile Phase-Specific Translocatable Substances that Influence Rooting Potential Using In Vitro Rooting Assays and Expression of a Specific Gene. United States Department of Agriculture, kwiecień 1998. http://dx.doi.org/10.32747/1998.7613038.bard.

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The objectives of the project for which substantial effort was put forth were to: 1) Verify the relationship between expression of a cDNA clone (HW103) and the rooting potential of reciprocally grafted cuttings of juvenile and mature lamina and petioles of Hedera helix L. 2) Detect rooting promoter fractions in exudates from the juvenile leaves of H. Helix by assaying for rooting with leaf petioles of juvenile and mature plants. 3) Isolate, purify and identify compounds which show activity in assays for rooting potential. Some objectives or aspects of the objectives of the original proposal were not pursued for the reasons put forth in the body of the report. The most significant findings of the project are: 1) The MS medium is a better medium than Romberg medium for performing the leaf petiole rooting assay. 2) HW103 gene expression is cell-type specific with higher levels of expression in mature than juvenile phase H. Helix petioles as evidenced by in situ hybridization which suggests a negative relationship between HW103 expression in specific cells involved in root initiation and the lack of rooting potential in mature petioles 3) HW103 gene expression may be lower in mature petioles which had been grafter to a juvenile H. Helix lamina than mature petioles that had been grafted to a mature lamina and this putative lower expression is related to formation of a higher number of roots. 4) HW103 gene expression is not related to auxin induced ethylene production. 5) Two distinct compounds that possess root initiation promoting activity can be detected mainly in diffusate of juvenile H. Helix leaves using mung bean hypocotyls and H. Helix leaf petioles in vitro. 6) H. Helix diffusate active fractions do not insistenlty promote rooting in avocado mini-cuttings. 7) Chemical identification of the active rooting compounds was not accomplished because of the death of Prof. Becker, one of the collaborators, and the resultant loss of his data. These results indicate that these may be a molecular basis for reduced rooting potential in mature H. Helix petioles and that there are diffusible (translocatable) compounds in juvenile H. Helix leaves which promote rooting in juvenile and mature H. Helix petioles and mung bean hypocotyls.

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Pritchard, Joy, H. R. Whay i A. Brown. Work type. Brooke, 2004. http://dx.doi.org/10.46746/gaw.2020.abi.wtype.

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Lin, Chuan-kai. Practical Type Inference for the GADT Type System. Portland State University Library, styczeń 2000. http://dx.doi.org/10.15760/etd.367.

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Saha, Bratin, Valery Trifonov i Zhong Shao. Fully Reflexive Intensional Type Analysis in Type Erasure Semantics. Fort Belvoir, VA: Defense Technical Information Center, styczeń 2005. http://dx.doi.org/10.21236/ada436474.

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LaVallie, E., G. Smith, D. Sorenson i J. Volk. T type collimator. Office of Scientific and Technical Information (OSTI), styczeń 1989. http://dx.doi.org/10.2172/6451106.

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Barss, M. S., J. P. Bujak i G. L. Williams. Kerogen-type plots. Natural Resources Canada/ESS/Scientific and Technical Publishing Services, 1997. http://dx.doi.org/10.4095/209231.

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Miller, A. CellML Media Type. RFC Editor, październik 2006. http://dx.doi.org/10.17487/rfc4708.

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Martini, L., i G. Swallow. Wildcard Pseudowire Type. RFC Editor, maj 2007. http://dx.doi.org/10.17487/rfc4863.

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Wing, Jeannette M., i John Ockerbloom. Respectful Type Converters. Fort Belvoir, VA: Defense Technical Information Center, maj 1998. http://dx.doi.org/10.21236/ada345874.

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