Gotowe bibliografie tematyczne / Lactic acid – Physiological effect

Gotowa bibliografia na temat „Lactic acid – Physiological effect”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 12 lutego 2022

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Artykuły w czasopismach na temat "Lactic acid – Physiological effect"

Kolomin, N. A., i О. B. Soprunova. "THE EFFECT OF NEW LACTIC ACID BACTERIA ON GROWTH AND SURVIVAL OF HYDROBIONTS". Вестник Пермского университета. Серия «Биология»=Bulletin of Perm University. Biology, nr 2 (2020): 115–19. http://dx.doi.org/10.17072/1994-9952-2020-2-115-119.

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The article is devoted to the study and isolation of new isolates of lactic acid bacteria. During the study, 9 isolates of lactic acid bacteria were isolated and their physiological, biochemical, and production-valuable properties were studied.The isolates have sufficient acid-forming activity (56.5-110 To), expressed saccharolytic activity (breakdown glucose, lactose, sucrose, maltose and galactose), the ability to develop at high concentrations of NaCl. Four of the most active isolates were used to study the effectiveness of lactic acid bacteria in the feed composition. As a result of inclusion of studied isolates in aquarium fodders, positive effect of two isolates on fish-growing and biological indices of fish has been established. The obtained data indicate at the same time the biological safety of the studied cultures, as well as the increase in the growth intensity of aquarium fish.

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ITA, POLLA S., i ROBERT W. HUTKINS. "Intracellular pH and Survival of Listeria monocytogenes Scott A in Tryptic Soy Broth Containing Acetic, Lactic, Citric, and Hydrochloric Acids". Journal of Food Protection 54, nr 1 (1.01.1991): 15–19. http://dx.doi.org/10.4315/0362-028x-54.1.15.

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To study the effect of citric, acetic, lactic, and hydrochloric acids on Listeria monocytogenes Scott A, growth, survival, and intracellular pH (pHin) values were determined during growth in a pH-controlled fermentation vessel. Under the experimental conditions, L. monocytogenes Scott A grown in tryptic soy (plus yeast extract) broth survived even when the pH was reduced to 3.5. For most acids, L. monocytogenes maintained a pH gradient (intracellular pH-external pH) of about 1.0 pH unit and a pHin near 5.0. When the citric and lactic acid-treated cells at pH values 3.5, 4.0, and 4.5 were incubated for a longer time (24 h), both the pH gradient and the pHin values decreased. Although citric and lactic acids were more effective in lowering the pHin, acetic acid had the greatest effect on cell survival. A greater than 4-log reduction in cell number occurred when L. monocytogenes was held in acetic acid-treated broth for 24 h at pH 3.5 even though the pHin was 5.0. The results suggest that inhibition of L. monocytogenes by acids is caused not by a decrease in the intracellular pH, per se, but rather by specific effects of undissociated acid species on metabolic or other physiological activities.

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ARVIZU-MEDRANO, SOFÍA M., i EDUARDO F. ESCARTÍN. "Effect of Acid Shock with Hydrochloric, Citric, and Lactic Acids on the Survival and Growth of Salmonella Typhi and Salmonella Typhimurium in Acidified Media". Journal of Food Protection 68, nr 10 (1.10.2005): 2047–53. http://dx.doi.org/10.4315/0362-028x-68.10.2047.

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The effect of acid shock with hydrochloric, citric, or lactic acid on the survival and growth of Salmonella Typhi and Salmonella Typhimurium in acidified broth was evaluated. Salmonella serovars were acid shocked (1 h at 35°C) in Trypticase soy broth acidified with hydrochloric, citric, or lactic acid at pH 5.5. Unshocked cells were exposed to the same media that had been neutralized before use to pH 7.0. Shocked and unshocked cells were inoculated into broth acidified with hydrochloric acid (pH 3.0), citric acid (pH 3.0), or lactic acid (pH 3.8), and growth and survival ability were evaluated. The acid shock conferred protection to Salmonella against the lethal effects of low pH and organic acids. The adaptive response was not specific to the anion used for adaptation. The biggest difference in reduction of survival between shocked and unshocked strains (∼2 log CFU/ml) was observed when the microorganisms were shocked with lactic acid and then challenged with citric acid. Salmonella Typhi was more tolerant of citric acid than was Salmonella Typhimurium, but Salmonella Typhimurium had higher acid tolerance in response to acid shock than did Salmonella Typhi. The acid shock decreased the extension of the lag phase and enhanced the physiological state values of Salmonella Typhi and Salmonella Typhimurium when the pH of growth was 4.5. This increased ability to tolerate acidity may have an important impact on food safety, especially in the case of Salmonella Typhi, given the very low infectious dose of this pathogen.

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Nikanova, L. A. "ORGANIC ACIDS IN FEEDING OF PIGS AND THEIR EFFECT ON PRODUCTIVITY AND CLINICAL AND PHYSIOLOGICAL STATE". Problems of Veterinary Sanitation, Hygiene and Ecology 1, nr 2 (2018): 84–88. http://dx.doi.org/10.36871/vet.san.hyg.ecol.201802015.

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The influence of feed additive "Ormik" consisting of organic acids (formic acid, lactic acid, orthophosphoric acid, acetic acid), as a filler of diatomite crumb, introduced into concentrated fodders, on the biochemical parameters of blood serum of pigs and on productivity is considered in the article. The studied feed additive was added to the feed daily in the form of loose powder, mixing thoroughly. The initial dosage of the feed additive in the 1st week was 1 g/kg of feed, 2nd week and the following – 3 g/kg of feed. The average daily gain in the live weight of pigs in the experimental group was 11,0% higher than the control group. The animals of the experimental group were less sick and the safety of this group was 100%, in the control group it was 90%.

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Westerblad, Håkan, David G. Allen i Jan Lännergren. "Muscle Fatigue: Lactic Acid or Inorganic Phosphate the Major Cause?" Physiology 17, nr 1 (luty 2002): 17–21. http://dx.doi.org/10.1152/physiologyonline.2002.17.1.17.

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Intracellular acidosis due mainly to lactic acid accumulation has been regarded as the most important cause of skeletal muscle fatigue. Recent studies on mammalian muscle, however, show little direct effect of acidosis on muscle function at physiological temperatures. Instead, inorganic phosphate, which increases during fatigue due to breakdown of creatine phosphate, appears to be a major cause of muscle fatigue.

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Małolepsza-Jarmołowska, Katarzyna. "PHARMACEUTICAL ASSESSMENT OF GYNAECOLOGICAL POWDERS WITH SODIUM ALGINATE CONTAINING A LACTIC ACID-CHITOSAN COMPLEX". Progress on Chemistry and Application of Chitin and its Derivatives XXIII (10.09.2018): 130–39. http://dx.doi.org/10.15259/pcacd.23.13.

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The insufficient duration of the drug’s contact with the vaginal mucosa does not provide adequate pH, conditioning the physiological biocenosis of the organ. This effect is hampered by numerous anatomic and physiological conditions which do not facilitate prolonged contact of the drug with the application site. This study has shown the impact of the used excipients and the ratio of lactic acid to chitosan on pH, dynamic viscosity and adhesiveness of methylcellulose gels obtained from powders. The addition of sodium alginate and excipients to these complexes allows various formulations to be obtained over a wide range of pH. Rheological investigations revealed an increase in the dynamic viscosity of preparations containing lactic acid complexed with chitosan and sodium alginate in comparison to gels without sodium alginate. Studies of the work of adhesion showed the effect of glycerol, 1,2-propylene glycol and their concentrations on the value of the work of adhesion.

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Kapustian, Antonina Ivanovna, Natalia Cherno, Alexei Kovalenko, Kristina Naumenko i Igor Kushnir. "Products of Metabolism and Processing of Lactic Acid Bacteria as Functional Ingredients". Food Science and Applied Biotechnology 1, nr 1 (14.03.2018): 47. http://dx.doi.org/10.30721/fsab2018.v1.i1.13.

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Lactic acid bacteria (LAB) and bifidobacteria (BB) are unique substances that have a lot of biological and physiological effects. Structural components of LAB and BB – peptidoglycans, compounds of the muramylpeptide series, teichoic acids – have powerful immunological properties. Metabolites of LAB and BB – organic acids, hydrogen peroxide, bacteriocins, etc. – provide antagonistic activity, have an indirect impact on the immune system, reducing the antigenic load caused by pathogenic microorganisms. The expediency of peptidoglycans degradation of LAB and BB cell walls is substantiated. Low molecular weight products of the degradation can easily be absorbed and enter into biochemical processes, accelerating the expected functional-physiological effect. To obtain low-molecular products of peptidoglycans degradation, a combination of LAB and BB was used. The combination of LAB and BB is the sum of the test cultures of Lactobacillus acidophilus, Lactobacillus delbrueckii subsp. Bulgaricus, Bifidobacterium bifidum, Lactococcus cremoris, Streptococcus termophilus. Destruction of peptidoglycans of bacterial cell walls was carried out using a combination of disintegrating factors. The efficiency of destruction was determined by the accumulation of low molecular weight peptides (with molecular weight up to 1500 Da), amino acids and soluble protein in the disintegrate. It has been established that the highest accumulation of low molecular weight degradation products occurs when using autolysis followed by enzymatic hydrolysis during 180 min with the ratio of the enzyme : substrate 1 : 100. At the same time ≈ 53% of protein substances pass from insoluble to soluble state. The molecular weight of the obtained products is determined by the gel chromatography method. The qualitative and quantitative content of organic acids, amino acids and vitamins of group В in the hydrolysis products composition was investigated. It was shown that the obtained product possesses high biological effect in the experiment on animals.

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Mohammed, M. J., M. S. Mahdi, A. H. Jameel i K. M. Thalj. "THE ROLE OF LACTOBACILLUS CASEI AND LACTOBACILLUS ACIDOPHILLUS TO DECREASE THE BIOLOGICAL EFFECTS OF POTASSIUM BROMATE IN RATS". IRAQI JOURNAL OF AGRICULTURAL SCIENCES 52, nr 1 (24.02.2021): 70–78. http://dx.doi.org/10.36103/ijas.v52i1.1237.

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This study was conducted to investigate the ameliorative effect of lactic acid bacteria Lactobacillus casei and Lactobacillus acidophilus against Potassium bromate (25, 50) mg / kg toxicity by some physiological indicators in 35 of female rats after 21 days. The animals were divided into 7 groups within each group 5 animals weighted 140 – 155 g. The results showed a significant decrease (P<0.05) in value of Red blood cells (RBC), hemoglobin (Hb), White blood cells (WBC), Lymphocyte (LYM) and Platelets (PLT), While increasing the values of Granules (GRN). Also found that the addition of Potassium bromate Potassium bromate led to increase in cholesterol, triglyceride (TG), Low Density Lipoprotein (LDL) and blood glucose, while decreased the values of High Density Lipoprotein (HDL) for rats groups with increasing the concentration of Potassium bromate compared with control group. The addition of two types of lactic acid bacteria L. casei and L. acidophilus with Potassium bromate showed a positive effect to reducing the negative effect of Potassium bromate on blood and lipid profile parameters compared with the control group and Potassium bromate group. It is concluded that the lactic acid bacteria has protective effects and reduces the effects that Potassium bromate.

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Kreutz, Marina, Karin Fischer, Petra Hoffmann, Simon Volkl, Matthias Edinger, Reinhard Andreesen i Andreas Mackensen. "Inhibitory Effects of Lactic Acid on Human Antigen-Specific CD8+ T-Cells." Blood 104, nr 11 (16.11.2004): 3844. http://dx.doi.org/10.1182/blood.v104.11.3844.3844.

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Abstract A characteristic feature of inflammatory lesions or tumor sites is local acidosis, which is attributed to the local increase in lactic acid production. We studied the effect of such an acidic environment on the immune functions of antigen-specific CD8+ T-cells by incubating the cells in the presence of various concentrations of lactic acid for up to 48h. CD8+ T-cells were isolated from healthy donors and expanded by weekly stimulation with autologous dendritic cells pulsed with a mutated HLA-A2-binding Melan-A (ELAGIGILTV) peptide. The obtained T cell population consisted of at least 90% CD8+ and about 60% Melan-A specific T cells, as determined by Melan-A multimer staining. Incubation of CD8+ T cells with up to 20mM lactic acid for 24h did not cause T-cell apoptosis or cell death as determined by combined annexin/propidium iodide staining. However, the proliferative capacity of CD8+ T cells, as determined by 3H-thymidine uptake, was strongly inhibited. Similar results were obtained when we determined cytokine production and cytotoxic activity of the cells after a 24h culture period in 5-20 mM lactic acid. Production of both, IL-2 and IFN-gamma was strongly diminished in comparison to untreated cells, as determined by intracellular staining after stimulation with PMA/ionomycin for 5h in the presence of monensin. Analysis of the antigen-specific cytolytic capacity revealed that CD8+ T cells pre-cultured with lactic acid were less effective in killing antigen-loaded T2 target cells as compared to untreated CD8+ T cells. In parallel, the intracellular contents of the cytotoxic effector molecules granzyme-B and perforin was diminished. Re-adjusting the pH of the medium to a physiological value of pH7.4 could partially revert the effect of lactic acid. Treatment of CD8+ T cells with sodium lactate instead of lactic acid had no inhibitory effect. We conclude, that lactic acid is an important modulator of CD8+ T-cell function and may contribute, together with other factors, to immune escape mechanisms in the tumor environment.

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Radkowski, Adam, Iwona Radkowska, Jan Bocianowski, Adrian Cyplik, Karol Wolski i Henryk Bujak. "Effect of Amino Acids and Effective Microorganisms on Meadow Silage Chemical Composition". Agronomy 11, nr 6 (12.06.2021): 1198. http://dx.doi.org/10.3390/agronomy11061198.

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The effects of growth stimulants consist of activating plant physiological processes, which positively affects vegetative and generative growth, increasing the yield and its quality. The aim of the experiment was to study the effect of microbial and amino acid products on the quality of grassland silage; their application in different combinations was an experimental factor. According to the results, the foliar application of the amino acid and microbial products had a statistically significant effect on the chemical composition of silage. In comparison to control, silage produced from plants treated with those growth stimulants contained significantly more total protein in dry matter, while crude fiber content changed only slightly. In addition, due to higher lactic acid content, the quality of silage treated with the stimulants was higher than the quality of control plants. To sum up, the foliar treatment of plants with microorganisms in combination with amino acids resulted in a significant increase in the content of desired components, with a higher nutritional value of the silage.

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Rozprawy doktorskie na temat "Lactic acid – Physiological effect"

Anderson, Gregory Steven. "The relationship between excess CO2 and blood lactate in elite cyclists". Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28534.

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This study examined the relationship between expired non-metabolic CO₂ (EX CO₂) and the accumulation of blood lactate, while emphasis was placed on the ventilatory (EX CO₂ and VE/VO₂) and lactate threshold relationship. Twenty-one elite cyclists (15 males, 6 females) performed a progressive intensity bicycle ergometer test (PIT) during which ventilatory parameters were monitored on-line at 15 second intervals, and blood lactate sampling occured on each minute. Threshold values were determined for each of the three indices; excess CO₂ (EXTT), VE/V0₂ (VVTT), and blood lactate (LATT). The three threshold values (EXTT, VVTT, LATT) all correlated significantly (P<0.001) when each was expressed as an absolute VO₂ (1/min). A significant RM ANOVA (F=8.41, P<0. 001) and post hoc correlated t-tests demonstrated significant differences between the EIXTT and LATT (P<0.001) and the EXTT and VVTT values (P<0.025). The LATT occured at an average blood lactate concentration of 3.35 mmol/1, while the mean expired excess CO₂ volume at the EXTT was 14.04 ml/kg/min. Over an 11 minute range across the threshold values (EXTT and LATT), which were used as relative points of reference, the expired EXC02 volume (ml/kg/min) and blood lactate concentration (mmol/1) correlated significantly (r=0. 69, P<0. 001). Higher individual correlations over the same period of time Education, Faculty of
Curriculum and Pedagogy (EDCP), Department of
Graduate

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Tu, Jie, i 屠潔. "Lactic-acid-infusion-induced increase in interstitial ATP of rat skeletal muscle". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B41634238.

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Vukovich, Matthew D. "Effect of L-carnitine supplementation on muscle glycogen utilization and lactate accumulation during cycle exercise". Virtual Press, 1993. http://liblink.bsu.edu/uhtbin/catkey/862276.

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Two experiments were done to study the effects of L-carnitine supplementation (CNsup) during exercise. EXP 1, examined the effect of CNsup on lipid oxidation and muscle glycogen utilization during submaximal EX. Triglycerides were elevated by a fat feeding (90g fat), 3 h later subjects cycled for 60 min at 70% VO2max (CON). Muscle biopsies were obtained preEX, after 30 and 60 min of EX. Blood samples were taken preEX and every 15 min of EX. Subjects randomly completed two additional trials following 7 and 14 days of CNsup (6 g/day). During one of the trials, subjects received 2000 units of heparin 15 min prior to EX to elevate FFA (CNhep). There were no differences in V02, RER, HR, g of CHO and fat oxidized among the three trials. Serum total acid soluble (TASC) and free carnitine (FC) increased with CNsup (CON, 71.3 ± 2.9; CN, 92.8 ± 5.4; CNhep, 109.8 ± 3.5 mol·g'). Muscle carnitine concentration at rest was unaffected by CNsup. During EX, TASC did not change, FC decreased (p<0.05) and SCAC increased (p<0.05). With CNsup the decrease in FC was less (~50%) (p<0.05) and the increase in SCAC was greater (~200-300%) (p<0.05) compared to CON (free 65%; SCAC 150%). Pre and postEX muscle glycogens were not different. EXP 2, examined the effects of CNsup on blood lactate accumulation during maximal EX. Subjects cycled for 4 min at ~100% VO2max (CON). Exercise was repeated following 6 and 13 days of CNsup (6 g/day). Serum TASC and FC were elevated due to CNsup. Blood Lactate was measured prior to and 0, 3, 5, and 7 min postEX. CNsup resulted in less (p<0.05) lactate accumulation compared to CON. There were no differences between DAY-6 and DAY-13.
Human Performance Laboratory

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Barnett, Christopher. "The effect of L-carnitine supplementation on blood and muscle lactate accumulation during high intensity sprint cycling exercise". Virtual Press, 1993. http://liblink.bsu.edu/uhtbin/catkey/865941.

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This study examined the effects of 14 days of L-carnitine supplementation on blood and muscle lactate concentrations, and carnitine fractions, during high intensity sprint cycling exercise. Eight subjects performed three experimental trials - control I (CON I, 0 days), control II (CON II, 14 days), and L-carnitine (LCN, 28 days). Each trial consisted of a 4 min ride at 90% VO2max, followed by a rest period of 20 min, and then 5 x 1 min rides at 115% VO2max (2 min restbetween each). Following CON II, all subjects began dietary supplementation of L-carnitine for a period of 14 days (4 g/day). L-carnitine supplementation had no significant effect on either muscle carnitine or lactate concentrations following the 4 min 90% ride. Plasma total acid soluable and free carnitine concentrations were significantly higher at all time points following supplementation. Differences observed in blood hydrogen ion and lactate concentrations between CON I and CON II appear to be the result of an order effect. The data from the present investigation indicate that L-carnitine supplementation has no significant effect on blood or muscle lactate accumulation following high intensity sprint cycling exercise.
School of Physical Education

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Lu, Lin, i 鹿琳. "Mechanisms involved in the release of ATP from skeletal myoblasts at low pH". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47323772.

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Lactic acid, which induces pH depression, leads to ATP efflux from muscle to extracellular space: it was reported that CFTR was involved in this process. However, the mechanism by which lactic acid activated CFTR and brought about the ATP release is still unknown. This study was performed to investigate (1) what channels may be involved or even conduct ATP release, and (2) how lactic acid activated CFTR. Expression of the possible channels that may conduct ATP release in L6 cells was investigated using RT-PCR: ClC-2, ClC-3, ClC-7, CACC, VDAC, connexin 40, connexin 43 and pannexin 3 were expressed in L6. Incubation of cultured L6 cells with lactic acid (10 mM) increased the extracellular ATP from 0.6 ± 0.06 to 1.1 ± 0.09 nM (P ? 0.05), indicating that lactic acid stimulated ATP efflux in vitro. The non-specific chloride channel inhibitor, DIDS, failed to abolish the lactic-acid-induced ATP release, suggesting that DIDS-sensitive chloride channels were not involved in the ATP efflux. Among the non-specific inhibitors of connexin channels, gadolinium inhibited acidosis-induced ATP efflux, but carbenoxolone failed to inhibit it, and so the role of connexins remains uncertain. The specific inhibitor of CFTR, CFTRinh-172, and the non-specific open-channel blocker of CFTR, glibenclamide, both abolished the acidosis-induced ATP release, but another specific inhibitor of CFTR, GlyH-101, which blocks CFTR from the external side, failed to abolish the ATP release, suggesting that acidosis-induced ATP is dependent on CFTR-activation, but does not involve ATP moving through the CFTR chloride channel. We hypothesize that, at low pH, the Na+/H+ exchanger (NHX) extruded H+ out of the cell and the resulting intracellular Na+ was transported out by Ca2+/Na+ exchanger (NCX); the localized increase in Ca2+ activated adenyl cyclase (AC), thus elevating intracellular cAMP; cAMP-activated-PKA then phosphorylated CFTR, which regulated an ATP release channel. KT-5720, an inhibitor of PKA, abolished the acidosis-induced ATP release, and forskolin, an agent that elevates cAMP, stimulated it, suggesting that the cAMP/PKA pathway was involved. The specific inhibitor of NCX, SN-6 and KB-R7943, both abolished the acidosis-induced ATP release, supporting a role for NCX in mediating this process. However, amiloride, the non-specific inhibitor of NHX failed to abolish ATP efflux. The whole cell Cl- currents were studied in L6 cells: lactic acid increased the whole cell currents from 2.33 ± 0.10 to 3.54 ± 0.34 nA (P ? 0.05), and this lactic-acid-induced increase in Cl- current could be inhibited by CFTRinh-172, suggesting that the CFTR Cl- channel was opened at low pH. Moreover, forskolin increased whole cell Cl- currents, which supported a role for the cAMP/PKA pathway in the lactic-acid-induced increase in CFTR current. These data confirm that CFTR is involved in the lactic-acid-induced ATP release from L6 cells. The roles of the NCX and cAMP/PKA pathway in activating CFTR at low pH are supported, but further studies are required to determine whether the NHX is involved in CFTR activation and whether connexins participate in ATP release.
published_or_final_version
Physiology
Master
Master of Philosophy

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Hutton, Peter. "Antimicrobial plants of Australia have the potential to prevent lactic acidosis in ruminants". University of Western Australia. School of Animal Biology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0159.

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[Truncated abstract] Antimicrobial growth promoters are added to feed to prevent lactic acidosis in ruminant animals by selectively inhibiting rumen bacteria that produce lactic acid. However, recently imposed or impending bans on the use of antimicrobial growth promoters in animal production have lead to a critical need to find practical alternatives that are safe for the animal and consumer and that obtain similar production benefits. I investigated bioactive plants of Australia for their potential to prevent lactic acidosis in ruminants. The unifying hypothesis tested was that plants would be identified that selectively inhibit lactic acid-producing bacteria and consequently protect against lactic acidosis. This hypothesis was tested in a three phase process: phase 1, plant selection and collection; phase 2, a three stage protocol for screening plants and essential oils; phase 3, in vivo experiments and chemical fractionation of the most promising plant. I developed an in vitro bioassay that simulated acidosis by adding glucose to rumen fluid in Bellco tubes and incubating for 5 h (Chapter 4). The pH and gas production were used as indicators of acidosis and fermentation activity. I used this bioassay to screen ninety-five plants (dried and ground material from 79 species) and ten essential oils and included a negative control (oaten chaff) and a positive control (virginiamycin). One plant, Eremophila glabra, produced a similar pH (5.63) to the positive control (5.43) although it inhibited gas production to a moderate extent (P < 0.05). ... Seven serrulatane diterpenes were identified to be the major secondary metabolites in E. glabra. The metabolites were screened using a broth dilution and microtitre spectrophotometry method and were selective against S. bovis at between 320 and 1077 [mu]g/ mL. The serrulatanes from E. glabra were probably responsible for the activity against acidosis that I observed in vitro, because they selectively inhibited lactateproducing bacteria. It is also possible that a synergy between serrulatanes and possibly other metabolites are responsible for the activity observed in vitro. The results from my experiments support the role that bioactive plants may have to replace the antibiotics that are added to livestock feed. Australian plants were identified containing compounds that were active against the bacterial processes responsible for ruminant acidosis. To my knowledge this is the first work undertaken to identify bioactive plants of Australia for their potential to prevent acidosis. I developed in vitro screening bioassays that targeted key indicators of acidosis. These bioassays enabled me to identify 5 plants from the 104 screened that could potentially control acidosis. One of these plants in particular, E. glabra, showed a level of activity in vitro that was comparable to antibiotic protection against acidosis. The exciting in vitro results were not demonstrated in vivo but only one dose level of E. glabra was used, which was based on the in vitro work. In contrast to the in vitro system the rumen is a continuous flow system with greater complexity and it is possible that the concentration of E. glabra that I used in vivo was not optimum. This places importance on future dose response experiments to confirm the efficacy of E. glabra in vivo.

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Spence, Andrew J. "The Effect of Lactic Acid on Mast Cell Function". VCU Scholars Compass, 2014. http://scholarscompass.vcu.edu/etd/3629.

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This study shows for the first time the effect that L-(+)-lactic acid has on mast cell activation. Lactic acid is a byproduct of anaerobic glycolysis and is associated with inflammatory environments such as wounds, tumors and, asthma. In this study, pre-treatment with lactic acid altered cytokine production by bone marrow-derived mast cells (BMMC). Specifically, lactic acid enhanced cytokine secretion following IgE cross-linking, but decreased IL-33 mediated cytokine production. These effects were altered by genetic background, since C57BL/6 mast cells demonstrated the aforementioned result, but lactic acid had no effect on IgE-mediated cytokine production in 129/SvJ mast cells. The affected cytokines included IL-6, TNF, MCP-1, MIP-1α, IL-13, and VEGF. Lactic acid pretreatment promoted a G0/G1 cell cycle arrest. Investigation into the IL-33 signaling pathway showed lactic acid decreased TAK1 and JNK phosphorylation, while increasing phosphorylated AKT levels. Blocking JNK and TAK1 with a small molecule inhibitor mimicked the effects of lactic acid. Interestingly, lactic acid significantly increased IL-33 mediated VEGF. An in vitro angiogenesis assay confirmed that mast cells were pro-angiogenic in a lactic acid-rich environment. Taken together, these data show that lactic acid impacts mast cell function, possibly promoting a pro-angiogenic, anti-inflammatory phenotype.

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Hattingh, Melanie. "The effect of lactic acid bacteria and fungi on the malting of barley". Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/79911.

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Thesis (MSc)--Stellenbosch University, 2013.
ENGLISH ABSTRACT: Barley malt is the predominant raw material for beer brewing world-wide. To meet consumer demand, a constant high quality malt product is required. Malt quality is determined by the degree of substrate hydrolysis during germination and mashing which serves as fermentable substrates for alcoholic fermentation during brewing. It is often difficult to sustain malt of high quality due to inconsistent malt batches and poor germination capacities of dormant barley. External additives such as chemicals and gibberellic acid have been used to overcome these difficulties but are unwanted in the beverage industry. Maltsters are consequently always in search of alternative solutions. Microbes produce diverse enzymes which can contribute to substrate hydrolysis during germination. The development of such starter cultures might provide a natural and economically feasible alternative to augment barley germination. Starter culture technology has been employed in the malting industry, although the main focus has been to improve the microbial stability of malt. The exploitation of cultures with hydrolytic capabilities to augment barley germination is consequently largely unexplored. The aim of this study was to develop a starter culture which can contribute to the enzymatic degradation of barley polymers. Geotrichum spp. and Lactobacillus plantarum were isolated from substrates rich in polymers present in barley and screened for enzymatic capabilities. Geotrichum spp. produced cellulase, xylanase, protease and β-glucanase activities, while L. plantarum harboured cell-bound and extracellular α-amylase activities. These cultures were added in different combinations during the malting of Erica and SSG 564 cultivars, but did not enhance germination significantly. Improved malt parameters did not correlate with microbial enzyme activities and the data were not repeatable. Preliminary plate assays could thus not be used to predict enzyme production in a malting environment. Cell-free supernatants with known enzyme activities of Aspergillus sp., Trichoderma reesei and Rhizopus sp. significantly enhanced malt quality. To our knowledge, the use of fungal supernatant to augment malt modification is a novel concept. Supernatant is more convenient than starter cultures and will aid to deliver more constant malt products than live cultures, as known enzyme levels are added.
AFRIKAANSE OPSOMMING: Garsmout is wêreldwyd die oorheersende roumateriaal vir bier brou. Om die aanvraag van verbruikers te bevredig, word 'n konstante hoë gehalte mout produk vereis. Die kwailiteit van mout word bepaal deur die graad van substraathidrolise gedurende ontkieming, wat dien as fermenteerbare substraat vir alkoholiese fermentasie tydens verbrouing. Dit is dikwels moeilik om ŉ konstante, hoë gehalte, moutproduk te lewer as gevolg van variasie in mout en die swak ontkiemingsvermoë van dormante gars. Hierdie probleem kan oorbrug word met eksterne toevoegings soos chemikalieë en gibberelliensuur, maar dit is nie ŉ gewensde praktyk in die broubedryf nie. Vermouters is gevolglik gedurig op soek na alternatiewe oplossings. Mikroörganismes produseer diverse ensieme wat kan bydra tot substraathidrolise gedurende ontkieming. Die ontwikkeling van sodanige suurselkulture is moontlik 'n natuurlike en ekonomies praktiese alternatief om die ontkieming van gars te stimuleer. Suurselkulture is reeds in die moutindustrie gebruik, alhoewel die fokus hoofsaaklik was om die mikrobiese stabiliteit van mout te verbeter. Die konsep om kulture met hidrolitiese vermoëns te gebruik om garsontkieming aan te vul is gevolglik grootliks onverken. Die doel van hierdie studie was om 'n suurselkultuur te ontwikkel wat kan bydra tot 'n ensiematiese afbraak van die polimere in gars. Geotrichum spp. en Lactobacillus plantarum is uit substrate ryk aan polimere teenwoordig in gars geïsoleer en vir hul ensiem aktiwiteite getoets. Geotrichum spp. het sellulase, xylanase, protease en β-glukanase aktiwiteit getoon, terwyl L. plantarum sel-gebonde en ekstrasellulêre α-amilase aktiwiteit getoon het. Hierdie kulture is in verskillende kombinasies tydens die vermouting van Erica en SSG 564 kultivars bygevoeg, maar het nie tot ŉ verbetering in die ontkieming van die gars gelei nie. Geen korrelasie is gevind tussen verbeterde mout parameters en mikrobiese ensiemaktiwiteit nie. Die resultate was ook nie herhaalbaar nie. Voorlopige plaattoetse kan dus nie as 'n maatstaf gebruik word om ensiem produksie deur suurselkulture in vermounting te voorspel nie. Sel-vrye supernatante van Aspergillus sp., Trichoderma reesei en Rhizopus sp., met bekende ensiem aktiwiteit, het die gehalte van mout aansienlik verbeter. Sover ons kennis strek is die gebruik van supernatante van fungi om die ontkieming van gars te stimuleer ŉ nuwe konsep. Supernatant is meer gerieflik as suurselkulture en sal help om konstante mout produkte te lewer aangesien ensiemvlakke beter beheer kan word.

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Weng, Wei-Lien. "Antimicrobial effect of yogurt lactic acid bacteria and muscadine products on Enterobacter sakazakii". Diss., Mississippi State : Mississippi State University, 2008. http://library.msstate.edu/etd/show.asp?etd=etd-10272008-163451.

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Feeback, Matthew R. "Effect of Oral L-arginine Supplementation on Lactic Acid and Maximal Oxygen Consumption in Healthy Males". University of Akron / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=akron1240929188.

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Książki na temat "Lactic acid – Physiological effect"

Konstantinos, Papadimitriou, i SpringerLink (Online service), red. Stress Responses of Lactic Acid Bacteria. Boston, MA: Springer Science+Business Media, LLC, 2011.

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Japan. Kankyōshō. Kankyō Hokenbu. Kankyō Risuku Hyōkashitsu. Report on toxicity studies of diphenylarsinic acid (DPAA). Wyd. 2. [Tokyo]: Environmental Risk Assessment Office, Environmental Health and Safety Division, Environmental Health Dept., Environmental Policy Bureau, Ministry of the Environment, Japan, 2011.

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Balcazar, Dantel M. J., i Esmeralda A. Reinoso Perez. Glutamic acid: Chemistry, food sources and health benefits. Hauppauge, N.Y: Nova Science Publisher's, 2012.

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Pyruvate: The natural dietary supplement that increases exercise endurance, promotes fat loss, and regulates blood sugar metabolism. New Canaan, Conn: Keats Pub., 1997.

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Chayat, Golda, i Avital Yedidya. Glutamate: Functions, regulation, and disorders. Hauppauge, N.Y: Nova Science Publishers, 2011.

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Pal, Bimal C. Summary review of health effects associated with hydrogen cyanide. Research Triangle Park, NC: Environmental Criteria and Assessment Office, Office of Health and Environmental Assessment, Office of Research and Development, U.S. Environmental Protection Agency, 1990.

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Williams, R. Sam. Effect of dilute acid on the accelerated weathering of wood. [Madison, Wis.?: Forest Products Laboratory, 1988.

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Williams, R. Sam. Effect of dilute acid on the accelerated weathering of wood. [Madison, Wis.?: Forest Products Laboratory, 1988.

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Williams, R. Sam. Effect of dilute acid on the accelerated weathering of wood. [Madison, Wis.?: Forest Products Laboratory, 1988.

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Effah, Josephine, Bridget Osakwe i Mary Favour Imona. Liquid hate: Acid bathe of women in Nigeria. Ikeja: Project Alert on Violence Against Women, 2004.

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Części książek na temat "Lactic acid – Physiological effect"

Silva, Milena Fernandes da, Meire dos Santos Falcão de Lima i Attilio Converti. "Effect of Short-Chain Fatty Acids Produced by Probiotics". W Lactic Acid Bacteria, 124–41. Boca Raton : CRC Press, Taylor & Francis Group, [2020]: CRC Press, 2020. http://dx.doi.org/10.1201/9780429422591-8.

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Santivarangkna, Chalat, Ulrich Kulozik i Petra Foerst. "Storing Lactic Acid Bacteria: Current Methodologies and Physiological Implications". W Stress Responses of Lactic Acid Bacteria, 479–504. Boston, MA: Springer US, 2011. http://dx.doi.org/10.1007/978-0-387-92771-8_20.

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Fuller, Roy. "The Effect of Probiotics on the Gut Micro-ecology of Farm Animals". W The Lactic Acid Bacteria Volume 1, 171–92. Boston, MA: Springer US, 1992. http://dx.doi.org/10.1007/978-1-4615-3522-5_7.

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Aguilar-toalá, J. E., B. Vallejo-cordoba, A. F. González-córdova, R. García-varela, H. S. García i A. Hernández-mendoza. "Protective Effect Of Foodgrade Lactic Acid Bacteria Against Oxidative Stress". W Food Toxicology, 151–77. Toronto ; New Jersey: Includes bibliographical references and index.: Apple Academic Press, 2017. http://dx.doi.org/10.1201/9781315161075-6.

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Goodman, J. Clay, S. P. Gopinath, A. B. Valadka, R. K. Narayan, R. G. Grossman, R. K. Simpson i C. S. Robertson. "Lactic Acid and Amino Acid Fluctuations Measured Using Microdialysis Reflect Physiological Derangements in Head Injury". W Acta Neurochirurgica Supplement, 37–39. Vienna: Springer Vienna, 1996. http://dx.doi.org/10.1007/978-3-7091-6894-3_8.

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Robertson, Robert J., i Kenneth F. Metz. "Differential Effect of Blood Lactic Acid and pH on Peripheral Exertional Perceptions". W Psychophysics in Action, 141–51. Berlin, Heidelberg: Springer Berlin Heidelberg, 1989. http://dx.doi.org/10.1007/978-3-642-74382-5_12.

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Huang, Tzou-Chi, Hseng-Kuang Hsu, Hui-Yin Fu i Chi-Tang Ho. "Effect of Lactic Acid Fermentation on Quercetin Composition and Antioxidative Properties ofToona sinensisLeaves". W ACS Symposium Series, 46–56. Washington, DC: American Chemical Society, 2005. http://dx.doi.org/10.1021/bk-2005-0909.ch005.

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Lodi, R., R. Todesco, A. M. Vezzoni i M. Lanzanova. "Effect of Formaldehyde and Lysozyme on Lactic Acid Bacteria During Grana Cheese Ripening". W MILK the vital force, 60–61. Dordrecht: Springer Netherlands, 1986. http://dx.doi.org/10.1007/978-94-009-3733-8_51.

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Tovar, Clara A., M. Carmen Gómez-Guillén i M. Pilar Montero. "Effect of Chitosan Concentration on the Rheological Properties of Acetic and Lactic Acid Solutions". W Springer Proceedings in Materials, 20–24. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-27701-7_5.

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Debnath, Biswojit, i Golam Jalal Ahammed. "Effect of Acid Rain on Plant Growth and Development: Physiological and Molecular Interventions". W Contaminants in Agriculture, 103–14. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-41552-5_5.

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Streszczenia konferencji na temat "Lactic acid – Physiological effect"

Hsu, Shan-Ting, i Y. Lawrence Yao. "Effect of Film Formation Method and Annealing on Crystallinity of Poly(L-Lactic Acid) Films". W ASME 2011 International Manufacturing Science and Engineering Conference. ASMEDC, 2011. http://dx.doi.org/10.1115/msec2011-50205.

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Poly(L-lactic acid) (PLLA) has been shown to have potential medical usage such as in drug delivery because it can degrade into bioabsorbable products in physiological environments, and its degradation is affected by crystallinity. In this paper, the effect of film formation method and annealing on the crystallinity of PLLA are investigated. The films are made through solvent casting and spin coating methods, and subsequent annealing is conducted. The resulting crystalline morphology, structure, conformation, and intermolecular interaction are examined using optical microscopy, X-ray diffraction, and Fourier transform infrared spectroscopy. It is observed that solvent casting produces category 1 spherulites while annealed spin coated films leads to spherulites of category 2. Distinct lamellar structures and intermolecular interactions in the two kinds of films have been shown. The results enable better understanding of the crystallinity in PLLA, which is essential for its drug delivery application.

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Khairrudin, M. G., M. R. T. Khairol Anwar, A. S. Shafian, M. A. Sakinah i H. H. Suhaiza. "The effect of modifiers on Poly (lactic acid) properties". W 2013 IEEE Business Engineering and Industrial Applications Colloquium (BEIAC). IEEE, 2013. http://dx.doi.org/10.1109/beiac.2013.6560244.

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Mamayeva, Laura. "MORPHOLOGICAL AND PHYSIOLOGICAL INDICATORS OF LACTIC ACID BACTERIA FOR THE PRODUCTION OF PROBIOTIC PRODUCTS". W 19th SGEM International Multidisciplinary Scientific GeoConference EXPO Proceedings. STEF92 Technology, 2019. http://dx.doi.org/10.5593/sgem2019/6.2/s26.029.

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El Amine, Belaouedj Mohammed, Belbachir Mohammed, Alberto D’Amore, Domenico Acierno i Luigi Grassia. "Effect of Montmorillonite Clay upon the polycondensation of Lactic Acid". W IV INTERNATIONAL CONFERENCE TIMES OF POLYMERS (TOP) AND COMPOSITES. AIP, 2008. http://dx.doi.org/10.1063/1.2989006.

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Iozzino, Valentina, Vito Speranza i Roberto Pantani. "Effect of an acid filler on hydrolysis and biodegradation of poly-lactic acid (PLA)". W THE SECOND ICRANET CÉSAR LATTES MEETING: Supernovae, Neutron Stars and Black Holes. AIP Publishing LLC, 2015. http://dx.doi.org/10.1063/1.4937341.

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Fokina, N. A., G. T. Uryadova i L. V. Karpunina. "Exopolysaccharides of lactic acid bacteria: applied aspects". W 2nd International Scientific Conference "Plants and Microbes: the Future of Biotechnology". PLAMIC2020 Organizing committee, 2020. http://dx.doi.org/10.28983/plamic2020.075.

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Exopolysaccharides Lactococcus lactis B-1662 and, to a greater extent, Streptococcus thermophilus have a healing effect on burns in rats. The exopolysaccharide Streptococcus thermophilus also has a prebiotic effect in the poultry body.

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Kato, F., S. Omori, M. Matsushita i Y. Ohki. "Effect of Crystallinity on Electrical Conduction Characteristics of Poly-L-lactic Acid". W 2006 IEEE Conference on Electrical Insulation and Dielectric Phenomena. IEEE, 2006. http://dx.doi.org/10.1109/ceidp.2006.312051.

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Udayakumar, Mahitha, Gabriella Zsoldos i Mariann Kollár. "Study on Effect of Degradation of Poly(lactic acid) on its Properties". W MultiScience - XXXI. microCAD International Multidisciplinary Scientific Conference. University of Miskolc, 2017. http://dx.doi.org/10.26649/musci.2017.036.

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Ferreira, Ignatius, Andreas Leuteritz, Harald Brünig, Walter Focke i René Androsch. "Effect of DEET on the crystallinity of bicomponent poly(lactic acid) monofilaments". W FRACTURE AND DAMAGE MECHANICS: Theory, Simulation and Experiment. AIP Publishing, 2020. http://dx.doi.org/10.1063/5.0028369.

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Ray, Hamidie Ronald Daniel, i Muhammad Naufal Abdulrahman. "The Effect of Consumption of Palm Sugar on Cardiovascular Endurance and Lactic Acid". W 2nd International Conference on Sports Science, Health and Physical Education. SCITEPRESS - Science and Technology Publications, 2017. http://dx.doi.org/10.5220/0007063804900493.

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