Rozprawy doktorskie: „Kidneys”

1

Tang, Chi-wai Sydney. "The many facets of the renal proximal tubular epithelial cell in human". Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31992468.

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Tang, Chi-wai Sydney, i 鄧智偉. "The many facets of the renal proximal tubular epithelial cell inhuman". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31992468.

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3

Wallin, Lena. "99m Tc-DMSA renal scintigraphy in the diagnosis and follow-up of acute pyelonephritis in children". Lund : Dept. of Clinical Physiology, Lund University, 1997. http://books.google.com/books?id=6kFsAAAAMAAJ.

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4

Melnychuk, S. P. "Emoxypine prevents structural changes in kidneys in rats with acute kidney injury". Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18906.

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Antoniv, A. A. "Kidneys functional status in patients with chronic kidney disease and nonalcoholic steatohepatitis". Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18082.

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6

RYLANDER, LESLIE ANN. "PROXIMAL TUBULE SUSPENSIONS FROM RABBIT KIDNEY: AN IN VITRO SYSTEM FOR THE STUDY OF NEPHROTOXICITY". Diss., The University of Arizona, 1986. http://hdl.handle.net/10150/183785.

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The proximal tubule of the renal cortical nephron is highly susceptible to intoxication by chemical agents. An in vitro system was developed to study directly the effects of nephrotoxic chemicals on this renal sub-organ fraction without the complication of extrarenal factors. Segments of proximal tubules were isolated by a mechanical method from the kidneys of young rabbits. Tubules obtained by this method retained biochemical, functional, and morphological features comparable to those existing in vivo. Preliminary acute susceptibility studies demonstrated that the isolated proximal tubule segments were sensitive to a variety of known nephrotoxic agents that target the proximal tubule. These agents include halogenated hydrocarbons, heavy metals, and a halogenated vinyl cysteine conjugate. Incubation conditions were optimized to maintain the viability of proximal tubule suspensions for up to four hours. Longer incubation times made it possible to establish a chronology of early tubule responses to chemical intoxication. Long term incubation of proximal tubule suspensions with two model nephrotoxins, cadmium chloride and S-(trans-1,2-dichlorovinyl)-L-cysteine, produced in vitro tubule response patterns similar to those reported in vivo for these agents. While not entirely representative of in vivo exposure conditions, suspensions of isolated proximal tubules are an easily obtained system that proved equally applicable as a screening technique for nephrotoxic compounds or as an in vitro system for delineating proximal tubule response to chemical insult.

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7

Shweta, Amany 1971. "The renal sympathetic nerves : implications for vascular remodelling in the SHR kidney". Monash University, Dept. of Physiology, 2001. http://arrow.monash.edu.au/hdl/1959.1/8351.

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Antoniv, A. A. "The kidneys functional state in chronic kidney disease in patients with nonalcoholic steatohepatitis". Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18584.

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9

Chambers, Jeanette Kay. "Knowledge, attitudes, and uncertainty of adult patients with decreased kidney function". Connect to resource, 1991. http://rave.ohiolink.edu/etdc/view.cgi?acc%5Fnum=osu1260191207.

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10

Meyer, Amanda Jane. "The impact of prenatal glucocorticoid exposure on the ovine kidney". University of Western Australia. School of Women's and Infants' Health, 2006. http://theses.library.uwa.edu.au/adt-WU2006.0105.

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[Truncated abstract] In obstetric practice, pregnant women at risk of pre-term delivery between 24 and 34 weeks of gestation are administered synthetic glucocorticoids (betamethasone or dexamethasone) to induce fetal organ maturation. During this gestational period, the fetal kidney is undergoing a phase of rapid organogenesis with an increase in renal growth and active nephrogenesis occurring. The studies comprising this thesis examine the effects of prenatal betamethasone exposure on the fetal and adult ovine kidney. The central hypothesis of these studies was that exposure of the fetal kidney to betamethasone in late gestation would change renal structure and induce long-term alterations in the expression of glucocorticoid-sensitive genes and proteins. In the fetal studies, pregnant Merino ewes bearing single fetuses received single or repeated-weekly intra-muscular (i.m.) injections of betamethasone (0.5 mg/kg body weight) or saline commencing on day 104 of gestation (term is 150 days). Kidneys were collected from fetuses at 109, 116, 121 and 146 days of gestation (d). Using gold standard unbiased stereological techniques, the physical disector/fractionator method, total glomerular (nephron) number and glomerular volume were determined in 146 d fetal kidneys exposed to repeated maternal saline or betamethasone administration. In the adult study, kidneys were collected from 3.5-year-old sheep that had been exposed to ... In this thesis I have demonstrated that renal growth restriction as a result of betamethasone exposure is associated with a reduction in fetal nephron endowment. Although betamethasone does not appear to consistently alter nephron number or glomerular size, it may indirectly affect total nephron endowment through effects on renal growth. I have also provided evidence which suggests that lategestation betamethasone exposure in sheep does not program permanent alterations in the renal expression of genes or proteins involved in glucocorticoid hormone action or components of the renin-angiotensin system. Therefore, exposure of the fetal kidney to betamethasone during nephrogenesis may alter renal structure if kidney growth is perturbed; however, there are no persistent alterations in the expression of glucocorticoid-sensitive genes. These findings are consistent with the preservation of normal basal blood pressure in the adult sheep I studied and with the limited results from human studies of late-gestation maternal glucocorticoid administration.

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11

Bućin, Dragan. "Blood transfusion and HLA in renal transplantation prolonged graft survival related to disparity in HLA-A antigens /". Lund : Blood Centre and Institute of Medical Microbiology, University of Lund, 1994. http://catalog.hathitrust.org/api/volumes/oclc/38948963.html.

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Eash, Sylvia Iordanova. "Invasion of host cells by the human Polyomavirus BKV /". View online version; access limited to Brown University users, 2005. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&res_dat=xri:pqdiss&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&rft_dat=xri:pqdiss:3174596.

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13

White, Sarah L. "The epidemiology of lifestyle-related and social risk factors for chronic kidney disease, and approaches to the burden of disease". Thesis, The University of Sydney, 2009. https://hdl.handle.net/2123/28217.

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Background and objectives Chronic kidney disease (CKD) refers to a progressive and irreversible loss of kidney function, the key outcomes of which are end-stage kidney disease (ESKD), requiring dialysis or a kidney transplant, or premature death typically due to cardiovascular complications. CKD is identified either by evidence of kidney damage (especially proteinuria or albuminuria) or decreased kidney function, measured according to glomerular filtration rate (GFR). Prevention of CKD, and timely intervention where disease does occur, is an emerging public health priority. However, our understanding of the epidemiology of CKD is still limited, and the evidence base concerning potentially modifiable lifestyle-related risk factors is often deficient or contradictory. Awareness of CKD in the community is low, and informed public health approaches to the burden of disease rare. This thesis is presented as a collection of published works which explore the epidemiology of lifestyle-related and social risk factors for CKD in the general population, and consider potential strategic approaches to the burden of CKD in Australia and internationally. The majority of the analyses presented are based on data derived from the Australian Diabetes, Obesity and Lifestyle (AusDiab) study, a prospective national survey of diabetes, cardiovascular and kidney disease in Australians aged 25 years or older which completed 5-year follow—up in 2005.

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14

Webster, Angela C. "Immunosuppression and malignancy in end stage kidney disease". Connect to full text, 2006. http://hdl.handle.net/2123/1186.

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Thesis (Ph. D.)--University of Sydney, 2006.
Title from title screen (viewed 21 May 2007). Submitted in fulfilment of the requirements for the degree of Doctor of Philosophy to the School of Public Health, Faculty of Medicine. Includes bibliographical references. Also available in print form.

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15

Brunmark, Charlott. "Type IV collagen and renal disease". Lund : Dept. of Nephrology, University of Lund, 1994. http://books.google.com/books?id=owdrAAAAMAAJ.

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16

RUEGG, CHARLES EDWARD. "MECHANISMS UNDERLYING REGIOSELECTIVE ACUTE TUBULAR NECROSIS OF RENAL PROXIMAL TUBULAR SEGMENTS". Diss., The University of Arizona, 1987. http://hdl.handle.net/10150/184162.

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The convoluted (CPT) and straight (SPT) portions of the renal proximal tubule are susceptible to injury by a wide variety of chemical agents. These agents often affect the CPT or SPT selectively by proposed mechanisms usually attributed to tubular concentration, blood flow delivery patterns and tubuloglomerular feedback responses within the intact kidney. The innate cellular responses to chemical exposures remain virtually unexplored. Hence, the basic goal of this research was to develop an in vitro system that was conducive to examining the innate cellular differences in susceptibility between the CPT and SPT following in vitro exposure to mercuric chloride (HgCl₂), potassium dichromate (K₂Cr₂O₇)$ or hypoxic conditions. A renal cortical slicing technique was developed for these studies to position the CPT and SPT within discrete regions of slices made perpendicular to the cortical-papillary axis. An incubation vessel that could maintain the morophological and biochemical viability of slices for at least 12 hr was also developed. The selective necrosis of CPT induced by K₂Cr₂O₇ or hypoxic exposure, and SPT induced by HgCl₂, observed in vivo was reproduced in renal cortical slices exposed in vitro. Innate cellular uptake mechanisms were then investigated since the tissue distribution of each metal was found to be most concentrated within their respective injured cell type. The transport of PAH, TEA, phosphate, sulfate, glutathione and cysteine were examined as potential mechanisms for selective accumulation of these metals. K₂Cr₂O₇ caused a dose-dependent reduction in the uptake rate of sulfate by cortical slices, while phosphate, PAH, and TEA uptake were unaffected. Although HgCl₂ has a high affinity for sulfhydryl groups its uptake as a complex to glutathione or cysteine was not enhanced. HgCl₂ also had no affect on the uptake rate of PAH or TEA even though both HgCl₂ and K₂Cr₂O₇ were able to reduce the steady state accumulation of these organic substrates.

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17

Ree, Eirik. "Segmentation of Kidneys from MR-Images". Thesis, Norwegian University of Science and Technology, Department of Computer and Information Science, 2005. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-9212.

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Det har blitt utviklet en metode for semi-automatisk segmentering av nyrer fra 2D og 3D MR-bilder. Algoritmen foregår som en kombinasjon av en watershed segmentering og en modellbasert segmentering. For å løse problemet med at aktive konturer krever en svært god initialisering, brukes resultatet av watershed segmenteringen til å lage initielle konturer. Resultatet har blitt en god og fleksibel algoritme som gir gode resultater og lett kan brukes også på andre segmenteringsoppgaver.

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18

Slyvka, N. O. "Hepatorenal syndrome - histological changes in kidneys". Thesis, Программа 100-ї підсумкової науковової конференції професорсько-викладацького персоналу Вищого державного навчального закладу України "Буковинський державний медичний університет" 2019 року, 2019. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/14874.

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19

Gandhi, Deep B. "Magnetic Resonance Elastography of the Kidneys". The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu1531935420431137.

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20

Zelmer, Jennifer. "The economic burden of end-stage renal disease in Canada: present and future /". *McMaster only, 2005.

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21

Sheehan, Susan. "Exploring the Genetics Regulating Kidney Function". Fogler Library, University of Maine, 2007. http://www.library.umaine.edu/theses/pdf/SheehanS2007.pdf.

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22

Meadows, Susan Dove. "PERSISTENT NEPHROTOXICITY AND RENAL TUMOR PROMOTION IN SWISS-WEBSTER MICE FOLLOWING EXPOSURE TO 1,2-DICHLOROVINYLCYSTEINE (KIDNEY, CANCER)". Thesis, The University of Arizona, 1985. http://hdl.handle.net/10150/275292.

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23

Bolke, Mark Edward. "Renal Responses to Differential Rates of Blood Volume Expansion in the Toad, Bufo marinus". PDXScholar, 1995. https://pdxscholar.library.pdx.edu/open_access_etds/4973.

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Three aspects of renal function were measured in the toad, Bufo marinus (N=lO): (1) effect of rate of blood volume expansion on renal functions (UFR; GFR; urine and plasma ion concentrations; and ion excretion rates), (2) effect of hypo- and hyperosmotic blood volume expansions on renal functions, and (3) role of GFR and tubular processes in the differential response of UFR under different osmotic expansion stresses. Renal responses to differential rates of blood volume expansion have not been investigated in amphibians. Rate responses will be analyzed considering effects: ( 1) during infusion (neural, or, short term regulation of extracellular fluid volume) and (2) post infusion (hormonal, or, long term regulation of extracellular fluid volume). Volume expansions were administered with hypoosmotic (0.4%) saline and hyperosmotic (1.4%) saline, and ranged in rate from 4.0 to 20.6 ml/kg/min. This protocol is designed to present volume regulatory mechanisms with increased volume stimuli and different osmotic stimuli. Overall, infusion rate had no significant effects on renal responses measured: urine flow rate (UFR); glomerular filtration rate (GFR); urine and plasma ion concentrations; natriuresis; or kaliuresis. This was true for the infusion period and for the observed post infusion period (90 min). Rate was correlated with GFR in the hypoosmotic group (r=0.30, p=0.04) and natriuresis in the hyperosmotic group (r=0.34, p=0.03). A significant positive correlation was observed between UFR and GFR. Relative to treatment, UFR differed significantly; GFR response was inherently similar despite differences at individual intervals, indicating UFR differences between the treatments is due to tubular processes. Responses to hypoosmotic infusion included a significant diuresis, natriuresis, and a decreased urine sodium concentration, relative to hyperosmotic infusion. At low UFRs the hyperosmotic group produced urine relatively concentrated in sodium. Urine sodium concentration and UFR were positively correlated in the hypoosmotic infusion group -- at high UFRs, kidneys were unable to produce a dilute urine.

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24

Maxwell, Lynne. "Women's perceptions of factors that enhance and inhibit adaptation to chronic hemodialysis when renal transplantation is not an option". Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/28768.

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Factors Influencing Women's Adaptation to Hemodialysis When Renal Transplantation is not an Option The intent of this study was to explore and describe factors that influence adaptation from the perspective of women on hemodialysis for whom renal transplantation is not an option. Phenomenology was the research design selected for this study in order to understand the experience of these women clients. Data were collected during audio-taped interviews of eight women and were analyzed concurrently with data collection to identify common themes. Two central themes emerged: the adaptation process and the theme of connectedness. The adaptation process was described as a six-phase process. Connectedness was defined as being connected to others and/or sources of life's energy. Several key factors that either facilitated or interfered with adaptation were identified for each of these two themes. Key factors that facilitated adaptation throughout the adaptation process Included a first run on dialysis, experience with adversity, emotional and instrumental support, coping behaviors such as asserting control and reframing the situation, diversions, adequate rest and confidence in health-care professionals. Factors interfering with adaptation to hemodialysis throughout the adaptation process included the gradual and ambiguous nature of renal disease, increasing dependence, reduced energy, transportation to dialysis, compromised somatic health, difficulty with assertiveness, prolonged stressors and lack of confidence in health-care professionals. Specific factors that influenced connectedness were identified. The facilitating factors identified were satisfactory relationships, nurturing others, normalizing, a harmonious atmosphere on the hemodialysis unit and pleasurable activities. Key factors interfering with adaptation related to the connectedness theme were isolation from others, unsympathetic others, ineffective communication with health-care professionals, and exclusion from activities. The findings relative to the adaptation process were discussed in the light of the literature on adapting to illness and stress. Connectedness was discussed primarily in relation to the literature exploring the socialization of women. Implications for nursing practice, education and research arising from these findings were outlined.
Applied Science, Faculty of
Nursing, School of
Graduate

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25

Zhang, Wensheng. "Protein and oxygen transport across vasa recta in the renal medulla /". Thesis, Connect to Dissertations & Theses @ Tufts University, 2002.

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Thesis (Ph.D.)--Tufts University, 2002.
Adviser: Aurelie Edwards. Submitted to the Dept. of Chemical Engineering. Includes bibliographical references (leaves 210-219). Access restricted to members of the Tufts University community. Also available via the World Wide Web;

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26

Snisarenko, Dmytro. "Medium sized molecules clearance through artificial kidneys". Thesis, Toulouse 3, 2016. http://www.theses.fr/2016TOU30270/document.

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Malgré une longue histoire de développement, l'hémodialyse (rein artificiel) possède encore quelques limitations, telles que la perte des propriétés initiales de la membrane en cours de traitement à cause du colmatage et la mauvaise élimination des toxines urémiques de taille moyenne. La présente étude fait partie d'un projet européen nommé BioArt dont le but est d'apporter des solutions à ces limites. Dans cet objectif, l'un des partenaires du projet a proposé le développement d'un nouveau concept de membrane double couche au sein de laquelle sont incorporées des particules adsorbantes. Une caractérisation complète de cette nouvelle membrane était alors nécessaire, plus précisément l'impact de la matrice mixte sur l'élimination des toxines urémiques de divers groupes devait être évalué, ainsi que la propension du matériau membranaire à se colmater. Les études des phénomènes de colmatage sont classiquement menées à l'échelle macroscopique (faisceau de fibres creuses) sans analyse à l'échelle d'une fibre isolée. Le but premier de la présente thèse a alors été de proposer un dispositif permettant une étude du colmatage membranaire induit par la protéine à l'échelle microscopique. Un dispositif microfluidique transparent dans lequel la membrane polymère est insérée a été élaboré et mis en œuvre pour la filtration des protéines modèles : l'albumine de sérum bovin (BSA) et l'a-lactalbumine. Grâce au couplage avec la microscopie de fluorescence, différents modes d'adsorption des protéines sur la surface de la membrane ont été observés et liés aux variations des conditions hydrodynamiques à l'intérieur de la puce. Il a été constaté, sous certaines conditions, une différence dans l'accumulation de protéines entre l'entrée, le centre et la sortie du canal tandis que dans d'autres conditions cet effet s'annule. En outre, un phénomène inattendu, l'agrégation de l'a-lactalbumine, a été observé au cours de la filtration. La localisation dans le canal et la forme des agrégats dépendent également des conditions hydrodynamiques et de la pression transmembranaire appliquée. Dans le but d'optimiser la conception de la membrane vis à vis de son aptitude à éliminer des molécules de taille moyenne de la circulation sanguine, un modèle mathématique a été proposé. L'objectif du modèle était, en prenant en compte la présence de particules adsorbantes à l'intérieur de la membrane double couche, de rendre compte de la combinaison des trois mécanismes d'élimination du soluté : la convection, la diffusion et l'adsorption. Le modèle permet de prédire l'influence de divers paramètres tels que la diffusivité de la molécule, l'épaisseur de la membrane, la présence de la convection, la charge en particules adsorbantes, sur l'intensification des flux à travers la membrane. Le modèle semble être un outil utile pouvant être appliqué à l'optimisation de membranes pour l'élimination des toxines
Despite a long history of development, the hemodialysis procedure (artificial kidney) still possesses some limitations, such as loss of the initial properties of the membrane due to fouling and poor removal of the middle sized uremic toxins. The present study is part of an European project named BioArt the aim of which was to overcome these limitations. In that objective, one of the partners of BioArt project reported on the development of the novel promising concept of double layer membrane with embedded adsorptive particles. A thorough characterization of the new membrane was then necessary, more precisely the extent to which mixed matrix layer can improve the removal of the uremic toxins from various groups needed to be evaluated, as well as the propensity of the membrane material to become fouled. The studies of the fouling phenomena are conventionally performed at the macro scale (bundle of hollow fibers) without insights of what is happening at the scale of an isolated fiber. Therefore, the primary aim of the present Thesis was to transfer the research of the protein-induced membrane fouling from the macro to the micro scale. A novel transparent microfluidics device with the polymeric membrane inside has been developed and applied for the filtration of model proteins: bovine serum albumin (BSA) and a-lactalbumin. Thanks to the coupling of the microchip with the fluorescent microscopy, different patterns of protein deposition on the membrane surface were observed and related to the variations in the hydrodynamic conditions inside the microchip. It was found that at certain conditions one may observe the difference in protein accumulation in the inlet, the middle, and the outlet of the channel while at other conditions this effect vanishes. Additionally, the unexpected phenomena of a-lactalbumin aggregation was observed over the course of filtration. The location and shape of the aggregates were also dependent on the hydrodynamic conditions and the applied transmembrane pressure. Aiming to address the problem of membrane design optimization for the enhancement of the middle molecules elimination from the bloodstream, a mathematical model, which accounts for the presence of adsorptive particles inside the complex double-layer membrane, has been proposed. The objective of the model was to understand the interplay of three solute removal mechanisms: convection, diffusion, and adsorption. The model allows predicting the influence of various parameters such as molecule diffusivity, membrane thickness, the presence of convection, content of adsorptive particles on the flux intensification across the membrane. The developed model seems to be a useful tool, which may be applied to design optimized membranes for the removal of toxins

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Hii, Su-Ing. "Studies on the role of vascular endothelial growth factor in renal cell carcinoma /". St. Lucia, Qld, 2002. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16892.pdf.

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28

Manfredi, Eugene Trent. "Immunodiagnostic methods for the detection of bacterial kidney disease in salmonid fishes /". Thesis, Connect to this title online; UW restricted, 1986. http://hdl.handle.net/1773/5282.

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Zhou, Li. "The molecular mechanisms of aristolochic acid nephropathy". Click to view the E-thesis via HKUTO, 2009. http://sunzi.lib.hku.hk/hkuto/record/B43224349.

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30

Olson, Jeffrey Carter. "Design and modeling of a portable hemodialysis system". Thesis, Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/28250.

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31

宋勇 i Yong Song. "Melatonin receptors in kidneys of mammals and birds". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1994. http://hub.hku.hk/bib/B31234434.

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Song, Yong. "Melatonin receptors in kidneys of mammals and birds /". Hong Kong : University of Hong Kong, 1994. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13952110.

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33

Poornejad, Nafiseh. "Decellularization and Recellularization Processes for Whole Porcine Kidneys". BYU ScholarsArchive, 2017. https://scholarsarchive.byu.edu/etd/6554.

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Concern over kidney disease has increased dramatically in recent years within the medical community. It is estimated that approximately one in fifteen Americans, nearly 20 million people, experience chronic kidney disease with most of those diagnosed progressing to kidney failure. The ultimate treatment available for end stage renal failure is whole kidney transplantation. However, there are very few kidneys available for patients to receive and those patients who are fortunate enough to receive an organ must remain on immunosuppressive medication for the remainder of their lives. The United States Department of Health & Human Services have reported that 18 people die every day while on the waiting list for organ donations. The treatment is fairly successful as 69% of patients who receive a kidney transplant are still alive 5 years after the transplant. Tissue engineered organs could be a promising alternative for whole organ transplantation. The overall objective is to repopulate appropriate decellularized scaffolds from pigs, which are not immunogenic, with a patient's own cells to achieve a functional organ. Therefore, there would be an inexhaustible source of organs ready for transplantation without the risk of immune rejection. The naturally obtained scaffolds devoid of immunogens are a potential matrix to create artificial kidneys. Repopulation of decellularized rat kidneys with renal progenitor cells has been reported in previous studies. This dissertation reports the scale-up of the previous technology and building of partially functional human-sized kidneys. In the first step, we investigated various cell lysing agents and developed an automated decellularization procedure for whole porcine kidney decellularization. We also developed a preservation method for native and decellularized kidneys to avoid spoilage before and after decellularization. We also developed a decontamination procedure for whole porcine kidneys. Finally, we recellularized whole porcine kidney scaffolds with renal epithelial cells and achieved partial repopulation of the renal structure.

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Liu, Wa-ling. "Knowledge of dialysis patients on kidney transplantation". Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/b39727907.

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35

Liu, Wa-ling. "A preliminary study into the level of knowledge, attitudes and perceptions of dialysis patients on kideny [sic] transplantation /". View the Table of Contents & Abstract, 2005. http://sunzi.lib.hku.hk/hkuto/record/B39915153.

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36

Tang, Chi-wai Sydney. "Human kidney as an organ of complement synthesis : its regulation by tubular protein /". Hong Kong : University of Hong Kong, 2001. http://sunzi.lib.hku.hk:8888/cgi-bin/hkuto%5Ftoc%5Fpdf?B23295181.

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37

Lawson, Thomas Kyle Beard Thomas R. "Impact of the dialysis industry on kidney transplants". Auburn, Ala., 2009. http://hdl.handle.net/10415/1988.

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38

Melian, Nadia. "Basement membrane composition of Dag1 null chimaeric mice kidneys". Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=33809.

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The growth of an organism involves the proliferation and migration of cells within an extracellular matrix. As a cell surface receptor, the Dag1 gene product dystroglycan links the intracellular cytoskeleton to the extracellular basement membrane in many cells. Thought to act as a structural protein dystroglycan may also participate in signal transduction. This study aims to better understand the role of dystroglycan during kidney morphogenesis. I hypothesised that a lack of dystroglycan in the precursor cells of the kidney could lead to altered kidney growth. Chimaeric mice deficient in dystroglycan were generated to test this hypothesis. A total of 38 chimaeras had genetic contribution and histological analysis performed on their kidneys. Of the chimaeras analysed, only four demonstrated altered kidney morphology. Further histological, immunohistochemical and biochemical studies established whether a link existed between this morphology and a deficiency in dystroglycan. Normal laminar architecture and nephrotic structures of the kidneys suggest that normal kidney organogenesis occurred in the absence of dystroglycan. The pattern and expression level of basement membrane components suggests that normal basement membrane formation also occured in the absence of dystroglycan. Biochemical analysis revealed that although dystroglycan protein levels correlate with the genetic contribution of the chimaeric kidney, it does not correlate with the altered morphology. Ureter blockage causing hydronephrosis can explain the morphology observed. A deficiency of dystroglycan in the ureter may in turn have caused this blockage. These findings suggest that dystroglycan is not necessary for kidney organogenesis, since kidney development occurred normally in all 38 chimaeric animals irrespective of genetic contribution.

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Лобода, Андрій Миколайович, Андрей Николаевич Лобода i Andrii Mykolaiovych Loboda. "Energy supply of the kidneys in children with pyelonephritis". Thesis, Видавництво СумДУ, 2010. http://essuir.sumdu.edu.ua/handle/123456789/6758.

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Clavant, Steven Patrick 1978. "Factors that influence albumin processing by the kidney". Monash University, Dept. of Biochemistry and Molecular Biology, 2003. http://arrow.monash.edu.au/hdl/1959.1/5704.

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Broeders, Emine Nilufer. "Etude des réponses humorales en transplantation rénale". Doctoral thesis, Universite Libre de Bruxelles, 2015. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209068.

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Les nouveaux immunosuppresseurs utilisés en transplantation rénale depuis le début des années 2000 :mycophenolate mofetil (MMF), tacrolimus, Neoral (nouvelle formulation de la cyclosporine-Sandimmun) et les inhibiteurs du mTOR ont amélioré le contrôle du risque de rejet, ainsi que la survie du greffon. Ces progrès sont contrebalancés par un risque accru d’infections. Nous avons évalué l'impact des nouveaux immunosuppresseurs sur les défenses humorales anti-infectieuses en 2 parties. Pour la première partie, nous avons étudié les réponses humorales primaires contre des antigènes protéiques. La 1ère étude montre que les réponses après l’administration d’un anticorps monoclonal anti-CD3 (OKT3) en induction sont profondément et additionnellement inhibées par le MMF comparé à l'AZA, et par le Neoral comparé au Sandimmun, ce qui empêche la neutralisation de ce puissant immunosuppresseur. La 2ème étude analyse les réponses au vaccin adjuvanté contre l’influenza H1N1 pandémique de 2009. Seuls 44% des transplantés rénaux ont développé une séroconversion, contre 57% de patients hémodialysés et 90% de contrôles sains. Nous observons aussi que le MMF limite l’augmentation des titres d’anticorps après vaccination par rapport à l’AZA.

Pour la seconde partie, nous observons l’évolution de composants de l’immunité humorale et innée au cours de la 1ère année de greffe. La 3ème étude montre que l’incidence de l’hypogammaglobulinémie atteint 45% à 3 mois de greffe, et est encore de 30% à 1 an. Les taux de MBP diminuent progressivement ce qui augmente le risque de sepsis et d’infection virale (CMV), tandis que l’hypogammaglobulinémie combinée :IgG + [IgA ou IgM] est corrélée avec une incidence élevée d’infections précoces (86%, RR :2, P=0.048), surtout d’origine respiratoire. La 4ème étude, indique que les immunosuppresseurs diminuent intensément les titres en Ac spécifiques induits avant la greffe :les Ac anti-pneumococciques, de nature polysaccharidique (Ac T-indépendants) et surtout les Ac anti-Anatoxine tétanique, de nature protéique (Ac T-dépendants). L’ensemble de notre observation conclut que les immunosuppresseurs actuels, et plus particulièrement le Mycophenolate diminuent fortement la production et le maintien des immunoglobulines, et ont un impact infectieux important. Il en découle que les stratégies de vaccination recommandées méritent d'être appliquées et que la vigilance à l'égard des pathogènes doit être implémentée.

Doctorat en Sciences médicales
info:eu-repo/semantics/nonPublished

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MIRANDA, ADRIANA R. "Avaliação da expressão e localização da conexina 43 na injúria isquêmica renal aguda". reponame:Repositório Institucional do IPEN, 2011. http://repositorio.ipen.br:8080/xmlui/handle/123456789/10008.

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Made available in DSpace on 2014-10-09T12:33:46Z (GMT). No. of bitstreams: 0
Made available in DSpace on 2014-10-09T14:04:36Z (GMT). No. of bitstreams: 0
Dissertação (Mestrado)
IPEN/D
Instituto de Pesquisas Energéticas e Nucleares - IPEN-CNEN/SP

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Erdely, Aaron. "Progression of chronic renal disease in several animal models possible role of decreased renal nitric oxide production as a primary causative factor /". Morgantown, W. Va. : [West Virginia University Libraries], 2002. http://etd.wvu.edu/templates/showETD.cfm?recnum=2740.

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Wang, Yang. "Murine adriamycin-induced nephropathy : the roles of cell-mediated immunity and CD4+ T-lymphocytes". Thesis, The University of Sydney, 2000. https://hdl.handle.net/2123/27827.

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Yeung, Shing Joseph. "Role of mycophenolic acid in kidney transplantation". Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31981860.

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Jeyaraj, Selvi Chrysolyte. "A role for the mRNA-stabilizing protein HuR in protection from cellular ATP depletion". Columbus, Ohio : Ohio State University, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1186773861.

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Mendonza, Anisha E. "Strategies for the optimization of immunotherapy in kidney transplantation /". View online ; access limited to URI, 2007. http://0-digitalcommons.uri.edu.helin.uri.edu/dissertations/AAI3276998.

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Tang, Chi-wai Sydney, i 鄧智偉. "Human kidney as an organ of complement synthesis: its regulation by tubular protein". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2001. http://hub.hku.hk/bib/B31981768.

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廖華苓 i Wa-ling Liu. "Knowledge of dialysis patients on kidney transplantation". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/b39727907.

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Campbell, Fiona M. "The investigation of early physiological changes in renal function in childhood diabetes". Thesis, University of Dundee, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322219.

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