Rozprawy doktorskie na temat „Keratitis”
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Sueke, Henri. "Novel approaches in bacterial keratitis". Thesis, University of Liverpool, 2014. http://livrepository.liverpool.ac.uk/2006499/.
Pełny tekst źródłaKlocke, Julia. "Spontane bakterielle Keratitis in CD36-/- Knockout- Mäusen". Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-87190.
Pełny tekst źródłaClarke, Daniel William. "The pathogenic cascade of Acanthamoeba Keratitis". Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=153.
Pełny tekst źródłaOtri, Ahmad Muneer. "Infectious keratitis : a molecular and clinical study". Thesis, University of Nottingham, 2013. http://eprints.nottingham.ac.uk/13408/.
Pełny tekst źródłaSchubert, Tracey Lee Optometry & Vision Science Faculty of Science UNSW. "Increasing the ability of antibiotics to control S. aureus keratitis". Publisher:University of New South Wales. Optometry & Vision Science, 2008. http://handle.unsw.edu.au/1959.4/41516.
Pełny tekst źródłaDart, John Kenneth George. "Contact lens related ulcerative keratitis : epidemiology and pathogenesis". Thesis, University of Oxford, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293396.
Pełny tekst źródłaKozariychuk, N. Ya. "Approaches to recurrent meta-herpetic keratitis therapeutic treatment". Thesis, БДМУ, 2021. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18633.
Pełny tekst źródłaKeay, Lisa Jane Optometry & Vision Science Faculty of Science UNSW. "Public health impact of contact lens related microbial keratitis". Awarded by:University of New South Wales. School of Optometry and Vision Science, 2006. http://handle.unsw.edu.au/1959.4/26307.
Pełny tekst źródłaWilliams, David Leonard. "Canine chronic superficial keratitis : histochemical characterisation and clinical management". Thesis, Royal Veterinary College (University of London), 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.307438.
Pełny tekst źródłaLee, Ming Yang. "Allele-specific siRNA therapy for keratitis-ichthyosis-deafness syndrome". Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10052698/.
Pełny tekst źródłaFesser, Nicole. "Die Strahlentherapie der Keratitis superficialis chronica mit weichen Röntgenstrahlen /". Berlin : Mbv, 2008. http://d-nb.info/98997829X/04.
Pełny tekst źródłaMaberly, James. "Evaluating Severity of Microbial Keratitis Using Optical Coherence Tomography". Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/26884.
Pełny tekst źródłaChang, Eddie. "The role of perforin and chemokines in the pathogenesis of chronic corneal inflammation induced by herpes simplex virus type-1 infection". free to MU Campus, others may purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p3091911.
Pełny tekst źródłaLiu, Lei. "Immunology of herpes simplex keratitis and its treatment by corneal transplantation". Thesis, Available from the University of Aberdeen Library and Historic Collections Digital Resources. Online version available for University member only until Sep. 7, 2010, 2009. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?application=DIGITOOL-3&owner=resourcediscovery&custom_att_2=simple_viewer&pid=33585.
Pełny tekst źródłaHalenda, Ruth Marrion. "Moraxella bovis cytotoxin and cell detachment factor /". free to MU campus, to others for purchase, 1998. http://wwwlib.umi.com/cr/mo/fullcit?p9901239.
Pełny tekst źródłaHarney, B. A. "Investigations of a subunit vaccine in experimental herpes simplex keratitis". Thesis, University of Bristol, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.375020.
Pełny tekst źródłaChidambaram, J. D. "Studies in the diagnosis and pathophysiology of severe microbial keratitis". Thesis, London School of Hygiene and Tropical Medicine (University of London), 2018. http://researchonline.lshtm.ac.uk/4649231/.
Pełny tekst źródłaKozariichuk, N. Ya. "Certain therapeutic approaches to meta-herpetic keratitis treatment: case report". Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18144.
Pełny tekst źródłaKöhlein, Sophie. "Stellenwert der PCR zur Diagnostik von Keratitis und Uveitis anterior". kostenfrei, 2008. http://mediatum2.ub.tum.de/doc/633320/633320.pdf.
Pełny tekst źródłaGreen, Matthew Optometry & Vision Science Faculty of Science UNSW. "Epidemiology, microbiology, outcomes and trends in keratitis in Queensland 1999-2004". Awarded by:University of New South Wales. Optometry & Vision Science, 2007. http://handle.unsw.edu.au/1959.4/40595.
Pełny tekst źródłaFesser, Nicole [Verfasser]. "Die Strahlentherapie der Keratitis superficialis chronica mit weichen Röntgenstrahlen / Nicole Fesser". Berlin : Freie Universität Berlin, 2008. http://d-nb.info/1023095963/34.
Pełny tekst źródłaFahy, Gerald Thomas. "Alterations in Langerhans cells in the cornea during herpes simplex keratitis". Thesis, University of Bristol, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240031.
Pełny tekst źródłaEdwards, Catherine Patrice Optometry & Vision Science Faculty of Science UNSW. "The incidence of and risk factors for contact lens related microbial keratitis in Australia and New Zealand". Publisher:University of New South Wales. Optometry & Vision Science, 2008. http://handle.unsw.edu.au/1959.4/41406.
Pełny tekst źródłaElsahn, Ahmad. "Interactions between Pseudomonas aeruginosa bacteria and corneal fibroblasts in human microbial keratitis". Thesis, University of Southampton, 2016. https://eprints.soton.ac.uk/411240/.
Pełny tekst źródłaLeal, Sixto M. Jr. "Fungal Keratitis: Immune Recognition, Neutrophil-Hyphae Interactions and Fungal Anti-Oxidative Defenses". Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1339081455.
Pełny tekst źródłaKarmakar, Mausita. "INFLAMMASOME DEPENDENT AND INDEPENDENT IL-1BETA PROCESSING BY NEUTROPHILS DURING BACTERIAL KERATITIS". Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1396544303.
Pełny tekst źródłaStapleton, Fiona J. "The pathogenesis and epidemiology of contact lens related disease in cosmetic contact lens wearers". Thesis, City University London, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280544.
Pełny tekst źródłaLin, Michelle. "Facilitation of neutrophil migration through the corneal stroma during keratitis-Mmp8 and chemokines". Connect to text online, 2007. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1191012168.
Pełny tekst źródłaLin, Michelle. "Facilitation of Neutrophil Migration Through the Corneal Stroma During Keratitis - Mmp8 and Chemokines". Case Western Reserve University School of Graduate Studies / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=case1191012168.
Pełny tekst źródłaCabrera, Aguas Maria Paulina. "Development, implementation and evaluation of evidence-based treatment guidelines for herpes simplex keratitis". Thesis, The University of Sydney, 2019. https://hdl.handle.net/2123/21845.
Pełny tekst źródłaPereira, Aline Cardoso. "Avaliação clínica e histopatológica do polímero poli(butileno adipato-co-tereftalato) (PBAT) em córnea de coelhos e aplicação no tratamento de úlceras de córnea em cães". Universidade Estadual Paulista (UNESP), 2018. http://hdl.handle.net/11449/154797.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
As ceratites ulcerativas são comuns na rotina do médico veterinário de pequenos animais, visto que a córnea é uma estrutura vulnerável devido sua exposição ao meio externo. Por compreender uma das estruturas responsáveis pela refração luminosa e participante do mecanismo de formação da imagem, é de extrema importância a integridade da anatomia e transparência da córnea para esta continuar desempenhando suas funções. Estudos ainda são realizados com o intuito de viabilizar opções terapêuticas cirúrgicas para o tratamento de úlceras de córnea complicadas, tentando alcançar uma cicatrização com um menor dano à estrutura corneal e menor opacidade cicatricial, devolvendo a transparência da córnea. Visto que os polímeros biodegradáveis tem se mostrado alvo de pesquisas atuais para aplicações médicas, com este estudo objetivou-se avaliar originalmente a biocompatibilidade da membrana do polímero poli(butileno adipato-co-tereftalato) (PBAT) na córnea e posterior aplicação clínica deste material nas ceratites ulcerativas profundas. Para tal, foi realizada avaliação clínica experimental e histopatológica após enxertia interlamelar do PBAT em córnea de coelhos, ao longo de 60 dias, e acompanhamento da evolução clínica do emprego da membrana de PBAT no tratamento de ceratites ulcerativas complicadas em cães, comparando ao uso do enxerto conjuntival, ao longo de 90 dias. Devido aos baixos sinais de inflamação corneal clínicos e histopatológicos nos coelhos e a cicatrização corneal em todos os cães, sem ocorrência de déficit visual, com o presente estudo acreditamos ter viabilizado mais uma opção terapêutica para as ceratites ulcerativas na medicina veterinária.
Ulcerative keratitis are common in the routine of a small animals veterinary doctor, given that the cornea is a vulnerable structure due to its exposure to external environment. For containing one of the structures responsible for light refraction and participant in the mechanism of formation of images, it is of extreme importance the integrity and transparency of the cornea in order for it to continue to develop its functions. Studies are still performed with the intent of making feasible surgical therapeutic options for the treatment of complicated corneal ulcers, trying to reach cicatrization with less damage to the corneal structure and less scar opacity, seeking corneal transparency. Given that biodegradable polymers have been target of current research for medical applications, the objective of this study was to evaluate originally the biocompatibility of the poly (butylene adipate-co-terephthalate) polymer (PBAT) in the cornea and posterior clinical application of this material in deep ulcerative keratitis. It was performed clinical and histopathological evaluation after interlamellar grafting of PBAT in the cornea of rabbits, over 60 days, and follow-up of the clinical evolution of PBAT membrane in the treatment of complicated ulcerative keratitis in dogs, comparing to the use of conjunctival graft, over 90 days. Due to low levels of clinical and histopathological corneal inflammation found in rabbits and corneal cicatrization in all dogs, without occurence of visual deficit, with this study we believe it was made feasible another therapeutic option for ulcerative keratitis in veterinary medicine.
Chen, Yingxin, Weijia Yang, Minghong Gao, Michael Wellington Belin, Hai Yu i Jing Yu. "Experimental study on cryotherapy for fungal corneal ulcer". Springer, 2015. http://hdl.handle.net/10150/610295.
Pełny tekst źródłaDenk, Nora. "Der Effekt UV-blockierender Kontaktlinsen bei der Therapie der Keratitis superficialis chronica des Hundes". Diss., lmu, 2009. http://nbn-resolving.de/urn:nbn:de:bvb:19-106023.
Pełny tekst źródłaMakdoumi, Karim. "Ultraviolet light A (UVA) photoactivation of riboflavin as a potential therapy for infectious keratitis". Doctoral thesis, Örebro universitet, Hälsoakademin, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-20130.
Pełny tekst źródłaJordan, Lisa [Verfasser]. "Vorkommen von CaHV-1 bei Hunden mit Konjunktivitis, Keratitis und normalen Augenbefunden / Lisa Jordan". Berlin : Freie Universität Berlin, 2021. http://d-nb.info/1231276045/34.
Pełny tekst źródłaPanatieri, Lua Ferreira. "Avaliação da atividade amebicida de nanoemulsões contendo extrato hexânico de Pterocaulon balansae (Asteraceae) frente à Acanthamoeba sp". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/149471.
Pełny tekst źródłaTreatment for keratitis caused by Acanthamoeba is unspecific, long term and with low patient compliance, being the search of new treatment strategies a need. Non-aqueous extracts of some species of Pterocaulon exhibit antimycotic and anti-parasitic activity, usually attributed to the presence of coumarins. In this scenario, the aim of this work is the development of nanoemulsion to associate the coumarin-rich n-hexane extract of Pterocaulon balansae. Previously, the extract was prepared and characterized by high performance liquid chromatography with photodiode array detector. The presence of 4 major coumarins was detected, where 5-methoxy-6,7-methylene dioxycoumarin (5MMDC) was selected as chemical marker. This extract was associated to nanoemulsions composed of egg lecithin and medium chain triglycerides, prepared by spontaneous emulsification. The physicochemical characterization showed the formation of monodisperse nanoemulsions with 200-300 nm diameter, regardless the amount of extract incorporated (1.0-5.0 mg/mL). The amoebicidal activity of the formulations against Acanthamoeba castellanii was both dose-dependent and incubation time-dependent, being 24h of incubation and concentration of 1.25 mg/mL of the extract the optimal (~5% viability), with effect similar to chlorexidine control. Finally, in vitro cytotoxicity studies showed that human corneal epithelial cells were unaffected after incubation with nanoemulsions by MTT assay. These results suggest a potential of the coumarin-rich n-hexane extracts of Pterocaulon balansae associated to nanoemulsion as a new strategy for the treatment of ocular keratitis caused by Acanthamoeba.
Klocke, Julia [Verfasser], Peter [Akademischer Betreuer] Wiedemann i unbekannt [Gutachter] unbekannt. "Spontane bakterielle Keratitis in CD36-/- Knockout- Mäusen / Julia Klocke ; Gutachter: unbekannt unbekannt ; Betreuer: Peter Wiedemann". Leipzig : Universitätsbibliothek Leipzig, 2012. http://d-nb.info/1238076793/34.
Pełny tekst źródłaBanjo, Taiwo Abayomi. "Acanthamoeba mannose-binding protein : structural and functional characterisation of a therapeutic target for Acanthamoeba keratitis". Thesis, University of Leicester, 2018. http://hdl.handle.net/2381/42327.
Pełny tekst źródłaMcMullen, Jr Richard Joseph. "Equine keratitis and the possible involvement of equine adenovirus type 1 (EAdV1) and type 2 (EAdV2)". Diss., lmu, 2005. http://nbn-resolving.de/urn:nbn:de:bvb:19-34239.
Pełny tekst źródłaMoser, Melanie A. "A Descriptive Review of Balamuthia and Non-Keratitis Acanthamoeba Cases in the United States, 1955-2009". Digital Archive @ GSU, 2011. http://digitalarchive.gsu.edu/iph_theses/162.
Pełny tekst źródłade, Jesus-Carrion Steven. "Fungal Keratitis: Immune Evasion, Host-Pathogen Interactions, and Virulence Factors during Aspergillus Fumigatus Infection". Case Western Reserve University School of Graduate Studies / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=case1417783811.
Pełny tekst źródłaMachens, Matthias. "The outcome of corneal grafting and patients with stromal keratitis of herpetic and non-herpetic origin /". Bern : [s.n.], 2003. http://www.stub.unibe.ch/html/haupt/datenbanken/diss/bestell.html.
Pełny tekst źródłaKatragadda, Suresh Mitra Ashim K. "Design of amino acid prodrugs of acyclovir for improved bioavailability and therapeutic activity utility in treating ocular, oral and genital herpes infections /". Diss., UMK access, 2007.
Znajdź pełny tekst źródła"A dissertation in pharmaceutical sciences and chemistry." Advisor: Ashim K. Mitra. Typescript. Vita. Description based on contents viewed July 16, 2008; title from "catalog record" of the print edition. Includes bibliographical references (leaves 173-182). Online version of the print edition.
Perches, Cintia Sesso [UNESP]. "Uso de colírios à base de Citrus lemon no reparo de úlcera de córnea induzida em coelhos: avaliação clínica, histomorfométrica e imuno-histoquímca". Universidade Estadual Paulista (UNESP), 2011. http://hdl.handle.net/11449/99364.
Pełny tekst źródłaFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O objetivo do presente estudo foi avaliar e comparar por meio de exames oftalmológicos, histopatológicos e imuno-histoquímica para PCNA, o processo de reparação corneal de úlceras superficiais induzidas em coelhos, frente à utilização de colírios de óleo essencial de Citrus lemon, produto até então não utilizado em oftalmologia. Foram utilizadas 50 fêmeas da espécie leporina, todas submetidas à indução da úlcera superficial, constituindo-se 5 grupos experimentais de 10 animais cada. Em três grupos foram instilados colírios à base de óleo essencial de Citrus lemon, em diferentes concentrações, sendo 1,5% (GL1,5), 3% (GL3) e 5% (GL5). O grupo controle (GC) recebeu substituto da lágrima, e o grupo Tween 80 8% (GT) foi tratado com o diluente utilizado na produção dos colírios de citrus. Todos os protocolos foram realizados quatro vezes ao dia. Os grupos foram divididos, aleatoriamente, em dois subgrupos, de acordo com o período final de avaliação, sendo M1, coelhos avaliados após 24 horas, e M5, após 5 dias. Não houve diferença entre os tratamentos utilizados quanto aos sinais clínicos secreção ocular, hiperemia conjuntival, quemose e opacidade corneal. O grupo tratado com colírio de óleo essencial de Citrus lemon na concentração 1,5%, no período final de avaliação, apresentou maior sensibilidade ocular em relação ao GC, além de aumento da celularidade corneal, representada principalmente por células inflamatórias. Nas comparações entre os momentos iniciais e finais, os grupos tratados com substituto da lágrima, Tween 80 8% e colírio à base de óleo essencial de Citrus lemon 5% promoveram aumento na espessura epitelial na periferia da córnea e maior percentual de proliferação celular, na avaliação final. Quanto à úlcera de córnea, houve redução significativa da extensão total para leve...
The purpose of this study was to evaluate and compare through ophthalmic exams, histopathology and immunohistochemistry for PCNA, the repair process in superficial corneal ulcers induced in rabbits using eyedrops of Citrus lemon essential oil, a product not used in ophthalmology yet. Fifty female rabbits were submitted to induction of the corneal ulcer and then divided into 5 experimental groups of 10 animals each. Were instilled into three groups eyedrops of Citrus lemon essential oil, in different concentrations, being 1.5% (GL1, 5), 3% (GL3) and 5% (GL5). The control group (CG) received a tear substitute, and the Tween 80 8% group (GT) was treated with the diluent used in the production of eyedrops of citrus. All protocols were performed four times a day. The groups were divided randomly into two subgroups, according to the final period of evaluation, in the M1 rabbits were evaluated after 24 hours, and in the M5 after 5 days. There was no difference between treatments for clinical signs: ocular discharge, conjunctival hyperemia, chemosis and corneal opacity. In the final period of evaluation, the group treated with eyedrops of Citrus lemon essential oil in the concentration 1.5% showed a higher ocular sensitivity compared to the GC, and increased of corneal cellularity, represented mainly by inflammatory cells. In the comparison between the initial and final moments, the groups treated with tear substitute, Tween 80 8% and eyedrops of Citrus lemon essential oil 5% led to an increase in epithelial thickness at the periphery of the cornea and a higher percentage of cell proliferation, in the final evaluation. In the clinical evaluation of corneal ulcer, there was significant reduction in total length for mild or absent at the time of final evaluation in all groups; the exception was GL 3%, that showed a lower... (Complete abstract click electronic access below)
Trevisan, Brandi C. "Encystment of Acanthamoeba and Evaluating the Biobus Program". Digital Archive @ GSU, 2010. http://digitalarchive.gsu.edu/biology_diss/88.
Pełny tekst źródłaWilliams, Susan R. "Role of Mal/TIRAP in TLR2- and TLR4-, but not TLR5-Induced Corneal Inflammation". Cleveland, Ohio : Case Western Reserve University, 2010. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=case1259983828.
Pełny tekst źródłaChinnery, Holly Rose. "Dendritic cells and macrophages in the mammalian cornea : distribution, morphology, phenotype and their role in responding to microbial challenge". University of Western Australia. School of Anatomy and Human Biology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0217.
Pełny tekst źródłaDanboise, Brook Alicia. "Role of MAP Kinase in Fusarium Association With Contact Lenses". Digital Archive @ GSU, 2008. http://digitalarchive.gsu.edu/biology_diss/45.
Pełny tekst źródłaLu, Liang. "CLINICAL AND ANIMAL STUDIES OF LIPID-DERIVED PROTEIN MODIFICATIONS IN AUTISM, KIDNEY DIALYSIS, KERATITIS AND AGE-RELATED MACULAR DEGENERATION". Case Western Reserve University School of Graduate Studies / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=case1180231149.
Pełny tekst źródłaPerches, Cintia Sesso. "Uso de colírios à base de Citrus lemon no reparo de úlcera de córnea induzida em coelhos : avaliação clínica, histomorfométrica e imuno-histoquímca /". Botucatu : [s.n.], 2011. http://hdl.handle.net/11449/99364.
Pełny tekst źródłaBanca: José Joaquim Titton Ranzani
Banca: Alexandre Lima de Andrade
Resumo: O objetivo do presente estudo foi avaliar e comparar por meio de exames oftalmológicos, histopatológicos e imuno-histoquímica para PCNA, o processo de reparação corneal de úlceras superficiais induzidas em coelhos, frente à utilização de colírios de óleo essencial de Citrus lemon, produto até então não utilizado em oftalmologia. Foram utilizadas 50 fêmeas da espécie leporina, todas submetidas à indução da úlcera superficial, constituindo-se 5 grupos experimentais de 10 animais cada. Em três grupos foram instilados colírios à base de óleo essencial de Citrus lemon, em diferentes concentrações, sendo 1,5% (GL1,5), 3% (GL3) e 5% (GL5). O grupo controle (GC) recebeu substituto da lágrima, e o grupo Tween 80 8% (GT) foi tratado com o diluente utilizado na produção dos colírios de citrus. Todos os protocolos foram realizados quatro vezes ao dia. Os grupos foram divididos, aleatoriamente, em dois subgrupos, de acordo com o período final de avaliação, sendo M1, coelhos avaliados após 24 horas, e M5, após 5 dias. Não houve diferença entre os tratamentos utilizados quanto aos sinais clínicos secreção ocular, hiperemia conjuntival, quemose e opacidade corneal. O grupo tratado com colírio de óleo essencial de Citrus lemon na concentração 1,5%, no período final de avaliação, apresentou maior sensibilidade ocular em relação ao GC, além de aumento da celularidade corneal, representada principalmente por células inflamatórias. Nas comparações entre os momentos iniciais e finais, os grupos tratados com substituto da lágrima, Tween 80 8% e colírio à base de óleo essencial de Citrus lemon 5% promoveram aumento na espessura epitelial na periferia da córnea e maior percentual de proliferação celular, na avaliação final. Quanto à úlcera de córnea, houve redução significativa da extensão total para leve... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The purpose of this study was to evaluate and compare through ophthalmic exams, histopathology and immunohistochemistry for PCNA, the repair process in superficial corneal ulcers induced in rabbits using eyedrops of Citrus lemon essential oil, a product not used in ophthalmology yet. Fifty female rabbits were submitted to induction of the corneal ulcer and then divided into 5 experimental groups of 10 animals each. Were instilled into three groups eyedrops of Citrus lemon essential oil, in different concentrations, being 1.5% (GL1, 5), 3% (GL3) and 5% (GL5). The control group (CG) received a tear substitute, and the Tween 80 8% group (GT) was treated with the diluent used in the production of eyedrops of citrus. All protocols were performed four times a day. The groups were divided randomly into two subgroups, according to the final period of evaluation, in the M1 rabbits were evaluated after 24 hours, and in the M5 after 5 days. There was no difference between treatments for clinical signs: ocular discharge, conjunctival hyperemia, chemosis and corneal opacity. In the final period of evaluation, the group treated with eyedrops of Citrus lemon essential oil in the concentration 1.5% showed a higher ocular sensitivity compared to the GC, and increased of corneal cellularity, represented mainly by inflammatory cells. In the comparison between the initial and final moments, the groups treated with tear substitute, Tween 80 8% and eyedrops of Citrus lemon essential oil 5% led to an increase in epithelial thickness at the periphery of the cornea and a higher percentage of cell proliferation, in the final evaluation. In the clinical evaluation of corneal ulcer, there was significant reduction in total length for mild or absent at the time of final evaluation in all groups; the exception was GL 3%, that showed a lower... (Complete abstract click electronic access below)
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