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Veselič, Maja. "Vzhodnoazijska motivika lisic v delih Alme Karlin". Poligrafi 27, nr 107/108 (29.12.2022): 195–222. http://dx.doi.org/10.35469/poligrafi.2022.366.
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Svetovno popotnico in pisateljico Almo Karlin so na njeni poti okoli sveta posebej zanimali verovanja in prakse dežel, ki jih je obiskala. Med njimi so jo privlačili predvsem tisti, ki jih je v duhu časa in takrat cvetoče primerjalne religiologije imenovala za vraževerje, saj naj bi prav ti prestavili opazovalce in bralce v tuje svetove. V Vzhodni Aziji so jo med nadnaravnimi bitji najbolj navdušile lisice, ki jim v neobjavljenem besedilu Verovanje in praznoverje na Daljnem Vzhodu nameni največ pozornosti. Lisice so poleg budizma tudi vzhodnoazijski religijski element, ki se najpogosteje pojavlja v njenih literarnih delih. Prispevek najprej povzame verovanja in pripovedi o lisicah, ki jih je Karlin obravnavala v svojem poljudnoznanstvenem besedilu, nato pa njene zapiske umesti v kompleksen svet motiva lisice na Kitajskem in Japonskem, ki je neločljiv preplet ljudske religioznosti, folklornih elementov in literarnih pripovedi klasičnih besedil. V zadnjem delu sledi analiza podobe lisice v objavljenih kratkih zgodbah Alme Karlin z vzhodnoazijsko temo. Omembe lisic pogosto služijo umestitvi dogajanja v konkreten geografsko-kulturni prostor, medtem ko zgodbe, ki so spletene okoli lisičjih duhov, te predstavljajo skozi klasične literarne motive nezemeljskih lepotic, ki zapeljejo mladega moškega, ga obnorijo in mu posrkajo življenjsko energijo, da se znajde na robu smrti.
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Rihtaršič, Urška. "Odprta oblika in njen odmev v slovenski glasbi". Musicological Annual 54, nr 2 (15.11.2018): 281–306. http://dx.doi.org/10.4312/mz.54.2.281-306.
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Članek se ukvarja z odprto obliko in na podlagi pregleda reprezentativnih del skuša izluščiti njene osnovne značilnosti; pri tem so v oporo teoretski teksti, ki so jih skladatelji objavljali vzporedno z glasbenimi deli. Na podlagi ugotovitev se članek v nadaljevanju osredotoča na odprto obliko v delih mlajše generacije slovenskih skladateljev prvega povojnega obdobja in v kontekstu družbenega dogajanja skuša razložiti njene pojavne specifike.
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Chhabria, Sheetal. "Book review: Prashant Kidambi, Manjiri Kamat and Rachel Dwyer, eds, Bombay Before Mumbai: Essays in Honour of Jim Masselos". Indian Economic & Social History Review 59, nr 2 (kwiecień 2022): 257–59. http://dx.doi.org/10.1177/00194646221088538.
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Novak, Doroteja. "Hildegarda iz Bingna: Scivias". Keria: Studia Latina et Graeca 18, nr 1 (28.12.2016): 139. http://dx.doi.org/10.4312/keria.18.1.139-168.
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V zgodovini srečamo zgolj peščico žensk, ki bi tako močno zaznamovale svoj čas in okolje, v katerem so delovale, kot ju je sv. Hildegarda iz Bingna. Renska sibila, kot so jo poimenovali njeni kasnejši občudovalci, je s svojo bogato literarno zapuščino pomembno vplivala na razvoj teologije in mistike 12. stoletja. Tega so se zavedali že njeni sodobniki, ki so ji priznavali avtoriteto tako v cerkveni kot posvetni sferi. Vseeno pa se je kot ženska, ki je posegala na področja, tradicionalno rezervirana za moške, morala soočiti s številnimi preprekami in ovirami. Njeni vsestranski dosežki se lahko po obsegu in kvaliteti primerjajo z dosežki bolj znanih filozofov in učenjakov, ki so jim bile zgodovinske okoliščine morda bolj naklonjene. Njen holistični pristop, ki je viden v vseh njenih delih, z obilico inovativnosti povezuje teologijo, glasbo, medicino, naravoslovje in celo jezikoslovje, v katerih lahko zaznamo vplive antičnih in sodobnih virov, velikokrat pa so njena opažanja plod skrbnega opazovanja okolice, ki je med drugim močno vplivala na razvoj njene misli. Videnja, ki naj bi jih že od zgodnjega otroštva prejemala od Boga, so tako dobila končno podobo v pisni obliki prav v samostanskem okolju, najprej v Disibodenbergu in nato v Rupertsbergu, kjer so najprej nastala njena teološka dela, nato pa so jim sledila še ostala.
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McErlane, Flora, Gillian Armitt, Joanna Cobb, Kathryn Bailey, Gavin Cleary, Sharon Douglas, Laura Lunt i in. "CAPTURE-JIA: a consensus-derived core dataset to improve clinical care for children and young people with juvenile idiopathic arthritis". Rheumatology 59, nr 1 (26.06.2019): 137–45. http://dx.doi.org/10.1093/rheumatology/kez214.
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Abstract Objectives Data collected during routine clinic visits are key to driving successful quality improvement in clinical services and enabling integration of research into routine care. The purpose of this study was to develop a standardized core dataset for juvenile idiopathic arthritis (JIA) (termed CAPTURE-JIA), enabling routine clinical collection of research-quality patient data useful to all relevant stakeholder groups (clinicians, service-providers, researchers, health service planners and patients/families) and including outcomes of relevance to patients/families. Methods Collaborative consensus-based approaches (including Delphi and World Café methodologies) were employed. The study was divided into discrete phases, including collaborative working with other groups developing relevant core datasets and a two-stage Delphi process, with the aim of rationalizing the initially long data item list to a clinically feasible size. Results The initial stage of the process identified collection of 297 discrete data items by one or more of fifteen NHS paediatric rheumatology centres. Following the two-stage Delphi process, culminating in a consensus workshop (May 2015), the final approved CAPTURE-JIA dataset consists of 62 discrete and defined clinical data items including novel JIA-specific patient-reported outcome and experience measures. Conclusions CAPTURE-JIA is the first ‘JIA core dataset’ to include data items considered essential by key stakeholder groups engaged with leading and improving the clinical care of children and young people with JIA. Collecting essential patient information in a standard way is a major step towards improving the quality and consistency of clinical services, facilitating collaborative and effective working, benchmarking clinical services against quality indicators and aligning treatment strategies and clinical research opportunities.
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Timčíková, Zuzana. "Avtentičnost v delih avtobiografskega gledališča: pristopi milenijske generacije". Amfiteater 9, nr 2021-2 (30.06.2022): 194–96. http://dx.doi.org/10.51937/amfiteater-2022-1/194-196.
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Med umetniki iste generacije, t. i. milenijci, ki delujejo predvsem na neodvisni sceni, lahko opazimo določene podobnosti, kot jih kažejo in uporabljajo predvsem v gledaliških formah, temah in odnosu do dramskega besedila. Bolj kot izvirna dramska besedila jih zanimajo avtobiografska besedila. Avtor pri tem ne nastopa kot samostojna oseba, temveč sodeluje cel kolektiv avtorjev. Gre za skupino ustvarjalcev, vključno z igralci oziroma izvajalci, ki izoblikuje dokončno različico besedila. Zdi se, da je izražanje avtentičnosti tako prek besedila kot na odru poglavitni namen takih pristopov k dramatiki. Predmet interpretacije postanejo trivialne in vsakdanje življenjske zadeve. V središče pozornosti postavljajo ljudi kot lastno samopodobo ali pa ljudi kot osebe, ki jih poznajo iz prijateljskih ali družinskih krogov, iz medijev ali iz pripovedovanja drugih. Avtorji se navdihujejo pri samih sebi, pri svojih težavah in odnosu do življenja. Poleg tega ustvarjalci radi pripovedujejo o sebi, analizirajo svoja občutja in zaznave, kot da bi imelo to, da jih lahko definirajo pred gledalci, nanje terapevtski učinek in bi potrjevalo relevantnost njihovega odnosa do življenja. Kaj lahko taka avtentičnost, ki se izraža s samoprojekcijo umetnikov v besedila pa tudi v uprizoritve, nudi občinstvu? Ali pri občinstvu vzbuja globlje zavedanje in razumevanje življenja ali zgolj reciklira tisto, kar že vemo?
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Martini, Alberto, Angelo Ravelli, Tadej Avcin, Michael W. Beresford, Ruben Burgos-Vargas, Ruben Cuttica, Norman T. Ilowite i in. "Toward New Classification Criteria for Juvenile Idiopathic Arthritis: First Steps, Pediatric Rheumatology International Trials Organization International Consensus". Journal of Rheumatology 46, nr 2 (1.10.2018): 190–97. http://dx.doi.org/10.3899/jrheum.180168.
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Objective.To revise the current juvenile idiopathic arthritis (JIA) International League of Associations for Rheumatology (ILAR) classification criteria with an evidence-based approach, using clinical and routine laboratory measures available worldwide, to identify homogeneous clinical groups and to distinguish those forms of chronic arthritis typically seen only in children from the childhood counterpart of adult diseases.Methods.The overall project consists of 4 steps. This work represents Step 1, a Delphi Web-based consensus and Step 2, an international nominal group technique (NGT) consensus conference for the new provisional Pediatric Rheumatology International Trials Organization JIA classification criteria. A future large data collection of at least 1000 new-onset JIA patients (Step 3) followed by analysis and NGT consensus (Step 4) will provide data for the evidence-based validation of the JIA classification criteria.Results.In Step 1, three Delphi rounds of interactions were implemented to revise the 7 ILAR JIA categories. In Step 2, forty-seven questions with electronic voting were implemented to derive the new proposed criteria. Four disorders were proposed: (a) systemic JIA; (b) rheumatoid factor–positive JIA; (c) enthesitis/spondylitis-related JIA; and (d) early-onset antinuclear antibody–positive JIA. The other forms were gathered under the term “others.” These will be analyzed during the prospective data collection using a list of descriptors to see whether the clustering of some of them could identify homogeneous entities.Conclusion.An international consensus was reached to identify different proposed homogeneous chronic disorders that fall under the historical termJIA. These preliminary criteria will be formally validated with a dedicated project.
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Kranjc, Andrej. "Prispevek geografov Inštituta za raziskovanje Krasa k reševanju prostorske problematike". Dela, nr 6 (1.12.1989): 117–26. http://dx.doi.org/10.4312/dela.6.117-126.
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V 40 letih delovanja Inštituta za raziskovanje krasa ZRC SAZU je pri raziskavah sodelovalo 9 geografov. Med njihovimi 800 objavljenimi deli jih 205 obravnava prostorsko problematiko krasa. Od skupno 330 elaboratov jih je 80 aplikativne narave in pri večini so soavtorji tudi geografi.
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Morgan, Esi M., Jane E. Munro, Jennifer Horonjeff, Ben Horgan, Beverley Shea, Brian M. Feldman, Hayyah Clairman i in. "Establishing an Updated Core Domain Set for Studies in Juvenile Idiopathic Arthritis: A Report from the OMERACT 2018 JIA Workshop". Journal of Rheumatology 46, nr 8 (15.02.2019): 1006–13. http://dx.doi.org/10.3899/jrheum.181088.
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Objective.The current Juvenile Idiopathic Arthritis (JIA) Core Set used in randomized controlled trials (RCT) and longitudinal observational studies (LOS) was developed without the input of patients/parents. At the Outcome Measures in Rheumatology (OMERACT) 2016, a special interest group voted to reconsider the core set, incorporating broader input. We describe subsequent work culminating in an OMERACT 2018 plenary and consensus voting.Methods.Candidate domains were identified through literature review, qualitative surveys, and online discussion boards (ODB) held with patients with JIA and parents in Australia, Italy, and the United States. A Delphi process with parents, patients, healthcare providers, researchers, and regulators served to edit the domain list and prioritize candidate domains. After the presentation of results, OMERACT workshop participants voted, with consensus set at > 70%.Results.Participants in ODB were 53 patients with JIA (ages 15–24 yrs) and 55 parents. Three rounds of Delphi considering 27 domains were completed by 190 (response rate 85%), 201 (84%), and 182 (77%) people, respectively, from 50 countries. There was discordance noted between domains prioritized by patients/parents compared to others. OMERACT conference voting approved domains for JIA RCT and LOS with 83% endorsement. Mandatory domains are pain, joint inflammatory signs, activity limitation/physical function, patient’s perception of disease activity (overall well-being), and adverse events. Mandatory in specific circumstances: inflammation/other features relevant to specific JIA categories.Conclusion.Following the OMERACT methodology, we developed an updated JIA Core Domain Set. Next steps are to identify and systematically evaluate best outcome measures for these domains.
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Virant, Špela. "„Lasten odtenek“: Koncept individualnosti v dramskih delih Iz junaškega življenja meščanov Carla Sternheima". Journal for Foreign Languages 9, nr 1 (28.12.2017): 127–38. http://dx.doi.org/10.4312/vestnik.9.127-138.
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Prispevek, ki se opira na recepcijsko estetiko in na diskurzno analizo, se posveča konceptu individualnosti v komedijah Carla Sternheima, ki jih literarna veda združuje v cikel z naslovom Iz junaškega življenja meščanov, s posebnim poudarkom na njihovi recepciji v delih pisateljev W. G. Sebalda in Floriana Illiesa. V središču raziskave sta predvsem dva vidika, in sicer obravnava družbene kritike in koncept individualnosti, ki sta pri Sternheimu umeščena v kontekst kritike meščanske ideologije. Analiza recepcije pokaže, kako se je v preteklih sto letih pod vplivom različnih ideologij spreminjalo razumevanje teh dveh pojmov. Prispevek zagovarja tezo, da nova interpretacija Sternheimovih del lahko pokaže, kako nasprotja, ki jih vsebujeta oba pojma, vse do danes niso razrešena, temveč so se celo zaostrila.
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Collado, P., S. Lanni, O. De Lucia, P. Balint, S. Guillaume, C. Hernandez-Diaz, N. M. K. Sande i in. "POS1385 INTERNATIONAL CONSENSUS FOR ULTRASOUND DEFINITIONS OF TENOSYNOVITIS IN JUVENILE IDIOPATHIC ARTHRITIS: RESULTS OF A DELPHI PROCESS". Annals of the Rheumatic Diseases 81, Suppl 1 (23.05.2022): 1032.2–1033. http://dx.doi.org/10.1136/annrheumdis-2022-eular.1419.
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BackgroundMusculoskeletal Ultrasonography (US) is a suitable tool for the clinical assessment in juvenile idiopathic arthritis (JIA). Recently US definitions for normal components of pediatric joints and synovitis have been developed by the OMERACT US working group. Currently this group is working on development and validation of US definition for tenosynovitis as it is also an essential prerequisite for the reliable use of this technology in the pediatric age group.ObjectivesTo produce consensus-based definitions for US tenosynovitis in JIA through a Delphi process.MethodsWe undertook a Delphi process on US-defined tenosynovitis in children that consisted of two steps. As a prior systematic literature review showed that US anatomy of the tendons is similar to adults, a Delphi questionnaire was written based on the consensual definitions developed for and used in adults with rheumatoid arthritis [1, 2]. The Delphi questionnaire was sent to rheumatologists and pediatricians who perform pediatric US examination, asking them to rate their level of agreement with each statement of US-defined tenosynovitis. Group agreement was considered if ≥80% of responders scored an item as either 4 or 5.In the second step, the definitions were validated on 88 standardized US images displaying various degrees of tenosynovitis obtained from JIA patients at various ages. Tendons often involved in JIA were selected (foot and ankle tendons, hand and wrist tendons, bicep tendon.). US images of both normal and tenosynovitis elementary lesions were collected by the 18 experts participating in the OMERACT US task force on pediatric tenosynovitis. An agreement ≥70% was considered mandatory for accepting the definition as applicable in the rated image.ResultsThe response rate was 75% (28 out of 37) from the first Delphi questionnaire. Strong group agreement (≥86%) was obtained for the US definitions tested. The response rate was 88.9% (16 out of 18) from the Web-exercise after four rounds. The final definitions were validated on still images for all tendons, except for the biceps tenosynovitis in the age group 2-4 years (the definitions of elementary lesions and the global definition of tenosynovitis) as no image was available for this location and age group. Despite not reaching group agreement after the second and the third round for the US-defined normal finger pulley in children aged 8 years and younger (roughly 68% and 69% respectively), it reached a score of 99.8% after the fourth round.ConclusionUS definitions of tenosynovitis and its elementary components covering a wide pediatric age range were successfully developed through a Delphi questionnaire and validated in a web-based still images exercise. These results provide the basis for the standardized US assessment of tenosynovitis in clinical practice.References[1]Ultrasound in the assessment of tenosynovitis in juvenile idiopathic arthritis: systematic literature review. Collado P on behalf of the OMERACT Ultrasound Task Force. DOI: 10.1136/annrheumdis-2019-eular.3493[2]Reliability of a consensus-based ultrasound score for tenosynovitis in rheumatoid arthritis. Naredo E on behalf of the OMERACT Ultrasound Task Force. Ann Rheum Dis 2013;72:1328AcknowledgementsAG Bruyn, L Terslev, S Jousse-Joulin, A Rodriguez, M Steiner, E Inarejos, P Bøyesen, K Misaki, A Iagnocco, B Marston, T Cazenave, P Mandl, A Bruns.Disclosure of InterestsNone declared
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Stoustrup, Peter, Cory M. Resnick, Thomas Klit Pedersen, Shelly Abramowicz, Ambra Michelotti, Annelise Küseler, Carlalberta Verna i in. "Standardizing Terminology and Assessment for Orofacial Conditions in Juvenile Idiopathic Arthritis: International, Multidisciplinary Consensus-based Recommendations". Journal of Rheumatology 46, nr 5 (15.01.2019): 518–22. http://dx.doi.org/10.3899/jrheum.180785.
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Objective.To propose multidisciplinary, consensus-based, standardization of operational terminology and method of assessment for temporomandibular joint (TMJ) involvement in juvenile idiopathic arthritis (JIA).Methods.Using a sequential expert group–defined terminology and methods-of-assessment approach by (1) establishment of task force, (2) item generation, (3) working group consensus, (4) external expert content validity testing, and (5) multidisciplinary group of experts final Delphi survey consensus.Results.Seven standardized operational terms were defined: TMJ arthritis, TMJ involvement, TMJ arthritis management, dentofacial deformity, TMJ deformity, TMJ symptoms, and TMJ dysfunction.Conclusion.Definition of 7 operational standardized terms provides an optimal platform for communication across healthcare providers involved in JIA-TMJ arthritis management.
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Mertelj, Darja. "Pogostnost in raznolikost podrednih skladenjskih vzorcev v književnih delih Seta in La luna e i falò". Journal for Foreign Languages 2, nr 1-2 (31.12.2010): 7–24. http://dx.doi.org/10.4312/vestnik.2.7-24.
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Skladenjsko kompleksne povedi so pogosto vitalni del književnega jezika. Namen tega prispevka je predstaviti skladenjsko raznolikost dveh italijanskih daljših književnih besedil, primernih tudi za obravnavanje v srednješolskem okolju, in nakazati morebitne jezikovne težave, ki bi jih lahko imeli slovenski učenci zaradi skladenjske raznolikosti. Analiza se osredotoča na podredne stavke, ki jih uvajajo vezniki se, anche se in come se in ki lahko uvajajo različne odvisnike: večina je takih, ki slovenskemu in drugim slovanskim učencem italijanščine povzroča težave zaradi interferenc pri izboru ustrezne glagolske paradigme v odvisniku. Pokazalo se je, da se vsi obravnavani tipi odvisnikov pojavljajo v obeh italijanskih romanih Seta (slov. Svila) in La luna e i falò (slov. Luna in kresovi) z določeno stalnostjo, vendar jih ne moremo opredeliti kot zelo pogoste. Zaradi svojega sorazmerno sporadičnega pojavljanja, toda visoke raznolikosti, ne morejo tvoriti stabilnega vnosa za učence: uspešnost nezavednega usvajanja ni zelo verjetna. Potrebno je zavestno učenje zaradi drugačnih zakonitosti pri izbiri jezikovnih sredstev v obeh jezikih. Izsledki analize predstavljajo dodaten razlog, da naj bi bili v zavestno poučevanje in učenje italijanščine kot tujega jezika vključeni vsaj najpogostejši in prototipični tipi odvisnikov.
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O'Loughlin, Niall. "Melodični postopki v glasbi Iva Petrića". Musicological Annual 29, nr 1 (1.12.1993): 107–19. http://dx.doi.org/10.4312/mz.29.1.107-119.
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Glasba Iva Petrića (r. 1931) je bila vedno melodično usmerjena. Obenem pa je skladatelj vedno kazal in še vedno kaže zanimanje za instrumentalne tehnike in barve ter za prepričljivo formo. Njegova glasba petdesetih let, še posebej Sonate za pihalne instrumente, odseva tradicionalen pristop melodičnega pisanja, medtem ko v Sonatah za klarinet in rog postanejo Hindemithovi vplivi očitni. Precejšnjo melodično fleksibilnost kaže Klarinetni koncert, tako da s Koncentantno glasbo (1961-62) Petrićev stil doseže prehodno fazo, v kateri je nemalo melodičnih metamorfoz. V delih, kot sta Élégie sur le nom de Carlos Salzedo za harfo in Croquis sonores (1963) za komorni ansambel, imamo opraviti s serialnimi prijemi. V slednji skladbi je melodičen zapis fragmentaren, ritmično iregularen in uporablja vseh dvanajst poltonov. Pojavi se t.i. prostorska notacija. Sedem skladb za sedem instrumentov odseva enostavno serialnost, značilnost, ki je skladatelj poslej ni več razvijal. Simfonične mutacije (1964) predstavljajo začetek utrjevanja in pretanjevanja Petrićevih skladateljskih postopkov. Čeprav oblikovno zanimivo, se zdi to delo še posebej značilno zavoljo tematskih preoblikovanj in svobodne asociativnosti podobnih tipov tem kot povezujočega faktorja med posameznimi deli skladbe. Po vrsti komornih del je Petrić v letih 1968-69 ustvaril tri pomembne kompozicije: Integrale v barvah za orkester, Intarzije za ansambel in Quatour 1969 za godalni kvartet. V teh delih so melodične celice in motivi uporabljeni tako za izoblikovanje melodičnih linij kot tudi melodičnih tekstur. Vse te drobne melodične celice so podvržene vrsti iznajdljivih, a obenem slišnih preoblikovanj, pri čemer je opazna sinhronizacija melodičnih glasov. Petrićeva dela sedemdesetih let vključujejo sonatam podobne skladbe za klavir, komorne sestave in orkester s koncertantno tretiranimi solističnimi instrumenti. Tudi tukaj skladatelj manipulira in preoblikuje kratke melodične celice tako v melodične linije kot v spremljevalne teksture, ki jih prevevajo nesinhronizirani ostinati. Uporaba dolgih not in njihove razdelave je značilna za Lirizme za rog in klavir, Meditacije za klavirski trio, violinsko Sonato in še posebej za Quatuor 1979. V orkestralnih delih s solističnimi instrumenti so orkestralni parti veliko bolj razdelani in vodijo do učinkov, ki melodično kot taki niso slišni. Sinhronizacija melodičnih elementov je včasih natančna, kot na primer v Dialogues concertants za čelo, običajno - kot v Trois images za violino (1973) - pa je samo približna, vezana na sistem primarnih in sekundarnih dirigentskih intervencij. Pihalna dela, kot so Episodes lyriques (1973) za oboo in Jeux concertants (1978) za flavto, slonijo na kalejdoskopičnih teksturah, ki se poigravajo z melodičnimi fokusi. Osemdeseta leta kažejo Petrićevo vrnitev v "taktno" regularnost, v delih, kot sta Koncert za trobento in orkester (1986) in Moods and Temperaments (1987), ki pa vsemu navkljub odsevata melodične procese značilne za sedemdeseta leta.
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Skidmore, Zachary L., Iris van 't Erve, Keith Lumbard, Bahar Alipanahi, Laurel Keefer, Lorenzo Rinaldi, Jacob Carey i in. "Cell-free DNA fragmentation profiling for therapeutic response monitoring in metastatic colorectal cancer." Journal of Clinical Oncology 41, nr 16_suppl (1.06.2023): e15664-e15664. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e15664.
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e15664 Background: Currently available circulating cell-free DNA (cfDNA) assays require deep-targeted sequencing to detect cancer-specific mutations at low mutant allele frequency (MAF) levels in the blood. Recently, we developed a tumor-agnostic, mutation-independent approach that utilizes low-coverage whole genome sequencing called DELFI (DNA evaluation of fragments for early interception) Tumor Fraction (DELFI-TF), a model designed to predict plasma tumor fractions based on genome-wide fragmentation-related features. Here, we report the results of DELFI-TF applied to a prospective cohort of patients with metastatic colorectal cancer (mCRC). Methods: Overall, 692 longitudinal plasma samples collected from 153 initially treatment-naive mCRC patients participating in the phase III CAIRO5 study (NCT02162563) were sequenced at low coverage and used for training and cross-validation. In patients with tumor-tissue-proven RAS/BRAF mutations, the tumor fractions were quantified as the cfDNA MAF of the RAS/BRAF variant measured by droplet digital PCR (ddPCR). Using fragment-sequencing statistics, a Bayesian regression model was trained against the MAF of the tumor-specific driver RAS/BRAF variant in all longitudinal timepoints to generate DELFI-TF scores. Changes in longitudinal DELFI-TF scores during first-line therapy (DELFI-TF slopes) were examined to predict treatment response and survival outcomes. Results: The DELFI-TF scores were strongly correlated with RAS/BRAF cfDNA MAF measured by ddPCR ( Pearson, r= 0.85, p< 0.001). Baseline DELFI-TF correlated with dimensions of liver metastases reported in CT scans ( Pearson, r= 0.49, p< 0.001) as well as clinical response, with pre-treatment levels significantly lower in patients with a later-confirmed partial or complete response ( Wilcoxon, p< 0.05). Patients with low or negative DELFI-TF slopes presented with longer progression-free survival in the overall study population (13.4 months vs 10.4 months, HR = 2.03, 95% CI 1.25 to 3.32, Log-rank p< 0.01) and in patients who experienced durable clinical benefit (16.7 months vs 13.3 months, HR = 2.24, 95% CI 1.1 to 4.55, Log-rank p= 0.023). Patients with low or negative DELFI-TF slopes also experienced significantly longer overall survival (59.4 months vs 29.1 months, HR = 3.05, 95% CI 1.58-5.90, Log-rank p< 0.001). Tissue-informed focal and arm-level copy number changes were detected 4-12 weeks after liver metastases resection. Most patients detected as having a molecular relapse were diagnosed earlier than clinical recurrences identified by conventional imaging. Conclusions: DELFI-TF demonstrates the ability to use cfDNA fragmentomes to estimate cfDNA tumor burden with performance comparable to standard approaches for treatment response monitoring and clinical outcome prediction.
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Oberhoff, Bernd. "Podzavestna raven smisla v Mozartovi operi Idomeneo". Musicological Annual 45, nr 2 (1.12.2009): 89–105. http://dx.doi.org/10.4312/mz.45.2.89-105.
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Ob svojih kliničnih izkušnjah je psihoanaliza razvila nekaj metod, ki služijo razvozlavanju podzavesti in ki jih moremo koristno uporabiti ta razumevanje podzavestnih tem v glasbenih delih. Avtor predstavi dve takšni metodi – iritacijsko teorijo in analizo nasprotnega prenosa – ter pokaže, kako je s tema instrumentoma moč odkriti latetntni smisel Mozartove opera Idomeneo. Oba metodološka pristopa pokažeta, da pri opernem dogajanju, ki sicer prikazuje brezhiben odnos med očetom in sinom, gre v resnici za smrtni boj med obema.
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Schuurbiers, Milou, Alessandro Leal, Delasa Aghamirzaie, Bryan Chesnick, Erica Peters, Tony Wu, Debbie Jakubowski i in. "Analysis of cell-free DNA (cfDNA) fragmentomes and prediction scores across distinct molecular subtypes." Journal of Clinical Oncology 41, nr 16_suppl (1.06.2023): e15029-e15029. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e15029.
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e15029 Background: Liquid biopsies have the advantage of being convenient in collecting tumor-derived DNA for clinical use. Genome-wide analysis of cell-free DNA (cfDNA) fragmentomes has emerged as a promising approach to detect lung cancer based on the examination of sequencing features other than actionable mutations. Here we report initial analyses of the DELFI (DNA evaluation of fragments for early interception) technology in patients enrolled in the Dutch Lung Cancer Early Molecular Assessment (LEMA) trial (NCT02894853), a prospective, observational, and multicenter study, to evaluate fragmentation patterns in genotyped blood samples with actionable alterations irrespective of disease stage and histology subtype. Methods: Plasma samples from 576 patients with an established diagnosis of lung cancer but awaiting the start of definitive treatment were processed and examined using low-coverage whole-genome sequencing. A lasso model that incorporated genome-wide fragmentation profiles was trained on an internal Delfi Diagnostics cohort and used to generate patient-specific DELFI scores for participants in LEMA. Results: Enrollees comprised 531 individuals with non-small cell lung cancer, 38 with small-cell lung cancer, and 7 with unknown lung cancer type. Most patients were diagnosed with late-stage disease (28% stage I, 10% stage II, 26% stage III, and 36% stage IV). Current smokers (N = 238; 41%) and former smokers (N = 295, 51%) outnumbered never smokers (N = 43; 8%). Analysis showed a stepwise increase of the DELFI scores from T1 to T4 and N0 to N1-3 disease, associating aberrant fragmentation profiles with the overall tumor burden. Small-cell carcinomas and squamous cell carcinomas presented with higher DELFI scores than adenocarcinomas ( p< 1e-7, generalized linear model). Patients without a smoking history had similar scores to those who had a previous history of smoking. When adjusted for stage, mutation status in ALK, BRAF, EGFR, ERBB2, KRAS, MET, RET, and ROS were not associated with DELFI scores ( p= 0.5, likelihood ratio test). Similarly, PD-L1 staining did not significantly affect DELFI scores when a 1% cutoff was applied to cases with PD-L1 staining data ( p= 0.07, generalized linear model). Conclusions: Our results reveal that DELFI scores increase stepwise with stage and are higher in small-cell and squamous cell carcinomas. The LEMA study reinforces the potential usefulness of genome-wide cfDNA fragmentation profiling as a liquid biopsy approach for identifying patients with lung cancer regardless of smoking status, somatic driver mutation, and PD-L1 expression scores.
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Nizami, M. A. "Composite Culture under the Sultanate of Delhi By IQTIDAR HUSAIN SIDDIQUI". Journal of Islamic Studies 26, nr 2 (4.03.2015): 224–29. http://dx.doi.org/10.1093/jis/etv008.
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Wong, Kwok-Kin, Peter J. Mazzone, Jun-Chieh Tsay, Harvey I. Pass, Anil Vachani, Jeffrey C. Thompson, Allison Ryan i in. "Prospective evaluation of cell-free DNA fragmentation profiles for lung cancer detection." Journal of Clinical Oncology 41, nr 16_suppl (1.06.2023): e20521-e20521. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.e20521.
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e20521 Background: Annual lung cancer screening can save lives, but fewer than 10% of eligible persons participate each year. More widespread screening is hindered by cost, inaccessibility, and uncertainty over individual-level benefit vs risk. Screening rates could be raised by a simple, inexpensive initial blood test, if it were sensitive for cancer detection. The DELFI (DNA evaluation of fragments for early interception) technology uses low-coverage, whole-genome sequencing and machine learning to identify patterns of cell-free DNA (cfDNA) fragmentation associated with cancer. Here we report preliminary cfDNA analysis results from DELFI-L101 (NCT04825834), a prospective, observational, multistate case-control study to train and test DELFI classifiers for lung cancer detection. Methods: Enrollees were ≥50 years old with current or previous smoking histories of ≥20 pack-years and recent or planned chest CT imaging. Medical history was recorded at enrollment, and blood samples were collected for DELFI analysis. Repeated 10-fold cross-validation was used to develop a classifier for lung cancer detection. A split study approach is planned for independent validation of the classifier. Results: At this time, 242 individuals with lung cancer and 652 without cancer have enrolled. Most participants were ≥65 years old, and the proportions of men and women were similar. Lung cancer risk factors were present among both cases and controls. Like the lung cancer screening population, approximately half of lung cancer cases were stage I. Median DELFI scores were higher among individuals with lung cancer than no cancer, overall and across groups stratified by age or body mass index (BMI). Cross-validated area under the receiver operator characteristic curve was 0.81 for lung cancer detection. Clinically meaningful sensitivity to detect lung cancer was attained across all disease stages, with sensitivity increasing stepwise with stage. Conclusions: We developed a classifier based on cfDNA fragmentome patterns analyzed using DELFI that could differentiate between lung cancer cases and controls with cross-validated performance across age groups, BMI categories, and cancer stages. A blood-based DELFI fragmentome test could serve as a low-cost, high-performance blood test with potential to improve lung cancer screening efficiency. Clinical trial information: NCT04825834 .
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Gacoin-Marks, Florence. "Individualni spomin in družbena zgodovina v delih Annie Ernaux in Ivana Jablonke". Ars & Humanitas 12, nr 2 (27.12.2018): 188–202. http://dx.doi.org/10.4312/ah.12.2.188-202.
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V članku preučujem, kako se sodobni francoski avtobiografski roman spreminja in razvija iz osebne izpovedne proze v preplet avtobiografije, generacijskega romana in socialne proze, kakršnega v francoski književnosti doslej ni bilo. Tovrstni roman – ki slovenski prozi 20. stoletja ni tuj – bom natančneje opredelila skozi razmišljanje o metodoloških težavah, ki jih povzroča »avtosociobiografija«, kakor jo poimenuje pisateljica Annie Ernaux, in skozi podrobno analizo treh literarnih del s preloma med 20. in 21. stoletjem: v romanih La Place (Prostor, 1982) in Les Années (Leta, 2008) pisateljice Annie Ernaux (rojena leta 1940) ter v avtobiografski pripovedi En Camping-car (Avtodom, 2016) Ivana Jablonke (rojen leta 1973).
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Gacoin-Marks, Florence. "Individualni spomin in družbena zgodovina v delih Annie Ernaux in Ivana Jablonke". Ars & Humanitas 12, nr 2 (27.12.2018): 188–202. http://dx.doi.org/10.4312/ars.12.2.188-202.
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V članku preučujem, kako se sodobni francoski avtobiografski roman spreminja in razvija iz osebne izpovedne proze v preplet avtobiografije, generacijskega romana in socialne proze, kakršnega v francoski književnosti doslej ni bilo. Tovrstni roman – ki slovenski prozi 20. stoletja ni tuj – bom natančneje opredelila skozi razmišljanje o metodoloških težavah, ki jih povzroča »avtosociobiografija«, kakor jo poimenuje pisateljica Annie Ernaux, in skozi podrobno analizo treh literarnih del s preloma med 20. in 21. stoletjem: v romanih La Place (Prostor, 1982) in Les Années (Leta, 2008) pisateljice Annie Ernaux (rojena leta 1940) ter v avtobiografski pripovedi En Camping-car (Avtodom, 2016) Ivana Jablonke (rojen leta 1973).
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Stoustrup, Peter, Marinka Twilt, Lynn Spiegel, Kasper Dahl Kristensen, Bernd Koos, Thomas Klit Pedersen, Annelise Küseler i in. "Clinical Orofacial Examination in Juvenile Idiopathic Arthritis: International Consensus-based Recommendations for Monitoring Patients in Clinical Practice and Research Studies". Journal of Rheumatology 44, nr 3 (15.01.2017): 326–33. http://dx.doi.org/10.3899/jrheum.160796.
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Objective.To develop international consensus-based recommendations for the orofacial examination of patients with juvenile idiopathic arthritis (JIA), for use in clinical practice and research.Methods.Using a sequential phased approach, a multidisciplinary task force developed and evaluated a set of recommendations for the orofacial examination of patients with JIA. Phase 1: A Delphi survey was conducted among 40 expert physicians and dentists with the aim of identifying and ranking the importance of items for inclusion. Phase 2: The task force developed consensus about the domains and items to be included in the recommendations. Phase 3: A systematic literature review was performed to assess the evidence supporting the consensus-based recommendations. Phase 4: An independent group of orofacial and JIA experts were invited to assess the content validity of the task force’s recommendations.Results.Five recommendations were developed to assess the following 5 domains: medical history, orofacial symptoms, muscle and temporomandibular joint function, orofacial function, and dentofacial growth. After application of data search criteria, 56 articles were included in the systematic review. The level of evidence for the 5 recommendations was derived primarily from descriptive studies, such as cross-sectional and case-control studies.Conclusion.Five recommendations are proposed for the orofacial examination of patients with JIA to improve the clinical practice and aid standardized data collection for future studies. The task force has formulated a future research program based on the proposed recommendations.
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Raina, V., M. Bhutani, R. Bedi, A. Sharma, S. Deo, N. K. Shukla, B. K. Mohanti i G. Rath. "Analysis of early breast cancer (EBC) cases at IRCH, AIIMS, New Delhi". Journal of Clinical Oncology 22, nr 14_suppl (15.07.2004): 686. http://dx.doi.org/10.1200/jco.2004.22.90140.686.
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Ruthven, Orlanda. "Money mosaics: financial choice and strategy in a West Delhi squatter settlement". Journal of International Development 14, nr 2 (2002): 249–71. http://dx.doi.org/10.1002/jid.875.
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Golob, Nataša. "Gold und Bücher lieb ich sehr … 480 Jahre Staats- und Stadtbibliothek Augsburg. Katalog zur Cimelien-Ausstellung vom 19. Oktober bis 15. Dezember 2017". Ars & Humanitas 12, nr 2 (27.12.2018): 335–39. http://dx.doi.org/10.4312/ah.12.2.335-339.
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Na naključno odprtih straneh publikacije, ki je v podnaslovu opredeljena kot razstavni katalog, so nekateri pogledi na knjige in s knjigami povezane predmete presenetljivi: v njih vidimo sestrske stvaritve s tistimi iz slovenskih javnih knjižnic in arhivov. Seveda ima vsaka knjižnica svoje dragocenosti in posebnosti, noben fond nima zrcalne podobe v drugem mestu, a marsikateri pri nas hranjeni rokopis, prvotisk in grafika so s svojo vsebino in likovno podobo potrditve stikov, ki so jih generacije iz dežel Kranjske, Štajerske in Koroške od približno 10. do 16. stoletja vzdrževale s švabskim Augsburgom in bližnjimi kraji. Ob delih iz naših zbirk je bilo mogoče ničkolikokrat zapisati, da gre za stvaritve iz južne Nemčije ali celo Augsburga, vendar so se take ugotovitve osredotočile na pozno 15. stoletje, ta katalog pa dokazuje, da je zlitost literarnega in likovnega med obema deželama potekala vsaj od ok. 1200 dalje. Da je knjižnica hranišče spominov, ki jih brez materializirane oblike ne bi imeli, je jasno, a dela je treba dobiti pred oči.
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Golob, Nataša. "Gold und Bücher lieb ich sehr … 480 Jahre Staats- und Stadtbibliothek Augsburg. Katalog zur Cimelien-Ausstellung vom 19. Oktober bis 15. Dezember 2017". Ars & Humanitas 12, nr 2 (27.12.2018): 335–39. http://dx.doi.org/10.4312/ars.12.2.335-339.
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Na naključno odprtih straneh publikacije, ki je v podnaslovu opredeljena kot razstavni katalog, so nekateri pogledi na knjige in s knjigami povezane predmete presenetljivi: v njih vidimo sestrske stvaritve s tistimi iz slovenskih javnih knjižnic in arhivov. Seveda ima vsaka knjižnica svoje dragocenosti in posebnosti, noben fond nima zrcalne podobe v drugem mestu, a marsikateri pri nas hranjeni rokopis, prvotisk in grafika so s svojo vsebino in likovno podobo potrditve stikov, ki so jih generacije iz dežel Kranjske, Štajerske in Koroške od približno 10. do 16. stoletja vzdrževale s švabskim Augsburgom in bližnjimi kraji. Ob delih iz naših zbirk je bilo mogoče ničkolikokrat zapisati, da gre za stvaritve iz južne Nemčije ali celo Augsburga, vendar so se take ugotovitve osredotočile na pozno 15. stoletje, ta katalog pa dokazuje, da je zlitost literarnega in likovnega med obema deželama potekala vsaj od ok. 1200 dalje. Da je knjižnica hranišče spominov, ki jih brez materializirane oblike ne bi imeli, je jasno, a dela je treba dobiti pred oči.
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Rudaš, Jutka. "Poetični diskurz v romanih Pétra Esterházyja". Anali PAZU HD 4, nr 1-2 (14.03.2022): 1–9. http://dx.doi.org/10.18690/analipazuhd.4.1-2.1-9.2018.
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Razprava razgrinja poglavitne elemente poetičnega diskurza v delih Pétra Esterházyja. Avtorjeva celotna poetika namreč temelji na intertekstualnosti kot posebni literarnoumetniški strategiji ter na metaforični referenci, kjer je sama realnost v nekem smislu potencialno fiktivna in fantastična. Njegova dela so prežeta s prelomnimi razsežnosti medbesedilnosti, v katero je ujet vsak tekst, kjer je meja med znotraj- in zunajtekstualnim zabrisana, branje pa docela pretkano s citati, z referencami, z različnimi kulturnimi govoricami, družbeno-kulturnimi kodi. V labirintu fragmentov že omenjene citatnosti, avtoreferencialnosti, literarne aluzije, ki jih niza Esterházy stran za stranjo želim podrobneje prikazati to zapleteno mrežo prelomov in prehodov v njegovih romanih.
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Terslev, Lene, Annamaria Iagnocco, George A. W. Bruyn, Esperanza Naredo, Jelena Vojinovic, Paz Collado, Nemanja Damjanov i in. "The OMERACT Ultrasound Group: A Report from the OMERACT 2016 Meeting and Perspectives". Journal of Rheumatology 44, nr 11 (1.02.2017): 1740–43. http://dx.doi.org/10.3899/jrheum.161240.
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Objective.To provide an update from the Outcome Measures in Rheumatology (OMERACT) Ultrasound Working Group on the progress for defining ultrasound (US) minimal disease activity threshold at joint level in rheumatoid arthritis (RA) and for standardization of US application in juvenile idiopathic arthritis (JIA).Methods.For minimal disease activity, healthy controls (HC) and patients with early arthritis (EA) who were naive to disease-modifying antirheumatic drugs were recruited from 2 centers. US was performed of the hands and feet, and scored semiquantitatively (0–3) for synovial hypertrophy (SH) and power Doppler (PD). Synovial effusion (SE) was scored a binary variable. For JIA, a Delphi approach and subsequent validation in static images and patient-based exercises were used to developed preliminary definitions for synovitis and a scoring system.Results.For minimal disease activity, 7% HC had at least 1 joint abnormality versus 30% in the EA group. In HC, the findings of SH and PD were predominantly grade 1 whereas all grades were seen in the EA cohort, but SE was rare. In JIA, synovitis can be diagnosed based on B-mode findings alone because of the presence of physiological vascularization. A semiquantitative scoring system (0–3) for synovitis for both B-mode and Doppler were developed in which the cutoff between Doppler grade 2 and grade 3 was 30%.Conclusion.The first step has been taken to define the threshold for minimal disease activity in RA by US and to define and develop a scoring system for synovitis in JIA. Further steps are planned for the continuous validation of US in these areas.
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HRVATIN, Klara. "»Ko bom velik, bom umetnik.« Eksperimentalni peskovnik japonske avantgarde". Asian Studies 5, nr 1 (30.01.2017): 243–69. http://dx.doi.org/10.4312/as.2017.5.1.243-269.
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Umetniški center Sōgetsu, ki je eden od pomembnejših avantgardnih središč 60. let 20. stoletja, bi lahko opredelili kot umetniški »eksperimentalni peskovnik«. Japonski umetniki, ki so na svojih področjih danes že mednarodno priznani, so se prav v tem »peskovniku« imeli možnost preizkusiti v krogu interdisciplinarnih umetnikov in najti svoj umetniški slog. Dober primer takšnih ustvarjalcev so: filmski režiser Hiroshi Teshigahara (1927–2001), novelist Kōbō Abe (1924–1993) in glasbenik Tōru Takemitsu (1930–1996).V članku bomo orisali natančen pregled vseh umetniških združenj in njihovih dogodkov, ki so jih oblikovali umetniki v času delovanja Centra, od septembra 1958 (13. septembra je potekalo odprtje Centra) do marca 1971, ko je Center prenehal delovati. V ospredje bodo postavljena glavna združenja oziroma aktivnosti, predvsem s področij jazzovske glasbe, sodobne glasbe, eksperimentalnih filmov in animacije. Poiskali bomo skupen imenovalec vseh aktivnosti v tem »peskovniku« ter poudarili novosti, ki so jih glavni akterji gibanja z deli, ki so nastala v Centru, vnesli na področji glasbe in filma.
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Raina, V., M. Bhutani, R. Bedi, A. Sharma, S. Deo, N. K. Shukla, B. K. Mohanti i G. Rath. "Analysis of early breast cancer (EBC) cases at IRCH, AIIMS, New Delhi". Journal of Clinical Oncology 22, nr 14_suppl (15.07.2004): 686. http://dx.doi.org/10.1200/jco.2004.22.14_suppl.686.
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Paulose, N., A. Sinha i S. V. S. Deo. "A Study to Assess the Quality of Life of Postoperative Patients With Oral Cancer in B.R.A I.R.C.H., AIIMS, New Delhi". Journal of Global Oncology 4, Supplement 2 (1.10.2018): 100s. http://dx.doi.org/10.1200/jgo.18.14100.
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Introduction: Cancer is a leading cause of death in both developed and underdeveloped countries in the world. The Indian subcontinent accounts for one-third of the world burden of head and neck cancer. Surgery is the standard treatment of choice for head and neck cancers. It is imperative to give supportive care to improve the quality of life. Aim: To assess the quality of life of postoperative patients with oral cancer in B.R.A I.R.C.H, AIIMS, New Delhi. Methodology: The study was conducted at B.R.A.I.R.C.H, AIIMS, New Delhi. The data were collected by convenience sampling from 50 adults who underwent surgery for oral during June 2017 to December 2017. Standardized self-structured EORTC QOL(H&N) was used to assess the perceived level of the quality of life of postoperative patients with oral cancer during hospital stay and at one month follow-up. Ethical clearance was obtained from institutional ethics committee. Results: 80% patients were male. Majority of the patients underwent mandibulectomy (66%) modified neck dissection (60%) and regional flap reconstruction (56%). The major symptoms perceived during hospital stay were pain (98%), speech problem (84%), problem in opening mouth (82%), felt ill (80%), weight loss (74%), etc. and at one month follow-up were problem in opening mouth (90.6%), pain (90.5%), speech problem (83.6%), weight loss (82%), among many others. There was a significant decrease in the perceived pain (11.2 ± 2.99) at one month follow-up (9.12 ± 3.42). Conclusion: Most of the patients experience pain, problem in opening mouth, sticky saliva, speech problem, trouble in social contact, weight loss, etc.
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McIntyre, P., E. Grunfeld, E. Mykhalovskiy, L. Cicchelli, S. F. Dent, L. Zitzelsberger, L. Paszat i C. Earle. "Quality indicators for end-of-life breast cancer care: Is there agreement between stakeholder groups?" Journal of Clinical Oncology 24, nr 18_suppl (20.06.2006): 16034. http://dx.doi.org/10.1200/jco.2006.24.18_suppl.16034.
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16034 Background: Quality indicators (QIs) are tools designed to measure quality of care and help enhance quality through identifying areas needing improvement. Breast cancer offers a disease model to examine QIs for end-of-life (EOL) care. The objective of this study was to assess agreement among stakeholder groups in two Canadian provinces on QIs for EOL breast cancer. Methods: A qualitative study design using a modified Delphi method and focus groups at each study site. After a literature review, an expert panel identified 19 QIs that were potentially measurable using administrative data. The Delphi panels and focus group sessions incorporated the 19 QIs as discussion topics in Halifax, NS and Ottawa, Ont. The Delphi panels involved a multidisciplinary group of oncology health care professionals. Separate focus groups were conducted with women with metastatic breast cancer and bereaved caregivers. All group sessions were audio-taped, transcribed verbatim, audited and a thematic analysis was conducted. Results: A total of 23 health care professionals, 16 patients, 7 bereaved caregivers participated in the study. Participants attended only one group discussion, depending on group assigned. There was good agreement on QIs among patient and caregiver groups in both cities. The need for effective communication was identified as a major theme. The Delphi process yielded overall moderate agreement with QIs among health care professionals. Conclusion: Aspects of quality EOL care important to stakeholders may not be measurable from administrative data. Results from the Delphi panels indicate that patient preferences and differences in health care delivery between different jurisdictions modulated extent of agreement with QIs. No significant financial relationships to disclose.
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Gillespie, T., P. Dhillon, K. Ward, A. Aggarwal, D. Bumb, D. Kondal, N. Kaushik i in. "Feasibility and Results of Cancer Registry and Noncommunicable Disease Cohort Data Linkages in India". Journal of Global Oncology 4, Supplement 2 (1.10.2018): 65s. http://dx.doi.org/10.1200/jgo.18.53600.
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Background: Cancer registries worldwide are vital to determine cancer burden, plan cancer control measures, and facilitate research. Population-based cancer registries are a priority for LMICs by the UICC; the National Cancer Registry Program (NCRP) of India oversees 28 such registries. A primary function of registries is to combine data for the same individual from multiple sources. For other disease cohorts where cancer is an outcome of interest, registries can potentially connect information by linking datasets together. Barriers to successful registration and linkages include systems in which cancer is not a notifiable disease, no universal unique individual identifier exists, and lack of trained personnel. This study utilizes technology and infrastructure to develop better linkages, surveillance, and outcomes. Aim: To assess the feasibility of linking large cohorts designed for cardio-metabolic disease research with cancer registries in New Delhi and Chennai; determine additional steps required for linkage accuracy and completeness; and develop detailed protocols for future applications. Methods: A pilot protocol for linkage between a large diabetes cohort and cancer registries in Delhi and Chennai was developed using MatchPro, a probabilistic record linkage program developed for cancer registries. Probabilistic software links datasets together in the presence of uncertainty (eg misspelled or abbreviated names) to identify record pairs with high probability of representing the same individual. For this study, algorithms were developed to address unique aspects of names and demographics in India. The software and algorithms focused on: detecting duplicates in cancer registries; and linking registries with external files from diabetes cohorts. In Delhi, 3 1-year datasets covering 3 years (2010, 2011, 2012) were linked with the diabetes cohort; in Chennai, the linkage included 3 5-year datasets covering 15 years (2000-04, '05-'09, '10-'14). The unique ID (Aadhaar) is not collected or linked systematically between different systems at this point in time. Results: Linkage attempts yielded potential matches ranked according to probabilistic scores; highest scores were reviewed to determine true matches. In Chennai, this process yielded: (2010-2014) 21% self-reported (SR) cases matching perfectly, 36% requiring follow-up, 13 nonreported (NR) cases found; 2005-2009: 33% SR cases matched perfectly, 1 NR case found; 2000-2004: 1 NR case. Also, 2 training workshops on data linkages and software were held. Conclusion: Linkages between cancer registries and other data sources are feasible in LMICs using probabilistic record linkage software augmented by manual matching. Future efforts to use existing epidemiologic resources (cohorts) and cancer research infrastructure (registries and clinical centers) can enhance research including understanding shared risk factors and pathophysiologic mechanisms e.g., between cancer and other NCD.
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Mazurek-Łopacińska, Krystyna. "Book Review: Introduction to arts management by Jim Volz, London, Oxford, New York, New Delhi, Sydney: Bloomsbury, 2017". Cultural Management: Science and Education 2, nr 1 (30.06.2018): 97–102. http://dx.doi.org/10.30819/cmse.2-1.06.
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Corral, Mitra, Michelle Sotak, Benjamin Chastek, John R. Penrod, Jessica Cairns i David A. Williams. "Timing of testing for K-ras mutational status in metastatic colorectal cancer (mCRC)." Journal of Clinical Oncology 30, nr 4_suppl (1.02.2012): 441. http://dx.doi.org/10.1200/jco.2012.30.4_suppl.441.
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441 Background: The objective of this study was to examine physician perspectives on K-ras testing in mCRC at two time points: diagnosis of mCRC and after treatment failure. Methods: Interviews were conducted with 16 oncologists experienced in treating mCRC to obtain information on treatment patterns. Based upon the interview data, a two-round Delphi panel web survey was then used to obtain consensus on specific percentages of patients in a separate sample of 25 oncologists. Both samples were asked to respond to two scenarios: at metastatic diagnosis and after treatment failure. Results: The majority of interviewed physicians reported that they primarily test at diagnosis of mCRC versus later in treatment. Both the interviewed physicians and Delphi respondents said most patients have a tissue sample available at metastatic diagnosis for K-ras testing (Delphi median 90%, mean 81.2% at diagnosis, 78.8% after treatment failure). For patients without tissue, it was stated that a tissue sample would be obtainable in most patients (Delphi median 90%, mean 87.8% at diagnosis, 85.8% after treatment failure). Of patients with K-ras wild-type mCRC, the Delphi panel estimated that 75-80% would receive an EGFR inhibitor (mean 75.5% at diagnosis, 81.5% after treatment failure, median 80%) while only 0-5% of patients with K-ras mutated mCRC would receive an EGFR inhibitor (mean 4.6% at diagnosis, 5.3% at EGFR decision, median 0%). For a scenario where K-ras information is unknown, the Delphi panel estimated that a small percentage of patients may receive EGFR inhibitors (at diagnosis: mean 12.2%, median 5%; after treatment failure: mean 14.1%, median 0%) although it was noted this is uncommon and many insurers will not cover EGFR inhibitors without K-ras status. Conclusions: Current guidelines for mCRC recommend that K-ras testing be conducted as part of the diagnostic workup. In this study, two samples of oncologists reported that the majority of patients they treat are tested for K-ras mutations at metastatic diagnosis rather than later in therapy. Both samples reported minimal use of EGFR inhibitors in patients with K-ras mutated mCRC or patients with unknown K-ras status, consistent with clinical guidelines and many insurance policies.
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Segelov, Eva, David Chan, Ben Lawrence, Nick Pavlakis, Hagen F. Kennecke, Christopher Jackson, Calvin Law i Simron Singh. "Identifying and Prioritizing Gaps in Neuroendocrine Tumor Research: A Modified Delphi Process With Patients and Health Care Providers to Set the Research Action Plan for the Newly Formed Commonwealth Neuroendocrine Tumor Collaboration". Journal of Global Oncology 3, nr 4 (sierpień 2017): 380–88. http://dx.doi.org/10.1200/jgo.2016.006916.
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Purpose Neuroendocrine tumors (NETs) are a diverse group of malignancies that pose challenges common to all rare tumors. The Commonwealth Neuroendocrine Tumor Collaboration (CommNETS) was established in 2015 to enhance outcomes for patients with NETs in Canada, Australia, and New Zealand. A modified Delphi process was undertaken involving patients, clinicians, and researchers to identify gaps in NETs research to produce a comprehensive and defensible research action plan. Methods A three-round modified Delphi process was undertaken with larger representation than usual for medical consensus processes. Patient/advocate and health care provider/researcher expert panels undertook Round 1, which canvassed 17 research priorities and 42 potential topics; in Round 2, these priorities were ranked. Round 3 comprised a face-to-face meeting to generate final consensus rankings and formulate the research action plan. Results The Delphi groups consisted of 203 participants in Round 1 (64% health care providers/researchers, 36% patient/advocates; 52% Canadian, 32% Australian, and 17% New Zealander), of whom 132 participated in Round 2. The top eight priorities were biomarker development; peptide receptor radionuclide therapy optimization; trials of new agents in advanced NETs; functional imaging; sequencing therapies for metastatic NETs, including development of validated surrogate end points for studies; pathologic classification; early diagnosis; interventional therapeutics; and curative surgery. Two major areas were ranked significantly higher by patients/advocates: early diagnosis and curative surgery. Six CommNETS working parties were established. Conclusion This modified Delphi process resulted in a well-founded set of research priorities for the newly formed CommNETS collaboration by involving a large, diverse group of stakeholders. This approach to setting a research agenda for a new collaborative group should be adopted to ensure that research plans reflect unmet needs and priorities in the field.
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McNiff, Kristen K., i Shelley Fuld Nasso. "Redefining functional status as a key cancer outcome: Patient-led measure conceptualization and development." Journal of Clinical Oncology 37, nr 27_suppl (20.09.2019): 218. http://dx.doi.org/10.1200/jco.2019.37.27_suppl.218.
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218 Background: Multiple national quality committees have identified PRO-PMs as priority for cancer measure development. Further, measurement of ‘return to functional status’ (RFS) has been prioritized. Finally, stakeholders have called for more patient-centric approaches to measure development. Accordingly, NCCS initiated a project funded by AIR to lead conceptual development and pre-testing specification of PRO-PMs to assess RFS. Methods: RAND Delphi methodology was employed to achieve conceptual consensus and measurement priorities. First, diverse cancer survivors were convened as a Delphi Panel. Themes from panelist brainstorming and related social media outreach, coupled with a detailed literature search, informed the Delphi survey development. Standard RAND Delphi survey methodology was followed, and panelists completed Survey 1. Areas of disagreement and uncertainty were the focus of discussion during a 2-day meeting, followed by Survey 2 completion /scoring. Results: The panel concluded that the term ‘return to functional status’ was inadequate. Structured discussion led to outcome re-naming as redefining functional status following a cancer diagnosis/completion of treatment. The Delphi method revealed priority measurement areas for survivors who have completed cancer treatment, and those receiving long term treatment. Priority areas include: overall quality of life; overall physical health; general mental health; changes in cognitive function; emotional problems; depression; fatigue; pain; changing dietary needs; late effects/side effects of treatment; ability to process loss or grief; maintaining everyday activities; overall independence; sense of control; and resilience. Conclusions: NCCS is a novel organization to lead measure development. NCCS engaged a diverse panel and used an accessible, structured approach to enable cancer survivors themselves to play the leadership role. Next steps for the project include development of pre-testing specifications for the prioritized PRO-PMs. Subsequent efforts will seek measure testing and endorsement. Ultimately, this work will contribute pragmatic methods/learning for future patient-led measure development.
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Yanti, Eli Delvi, i Maya Macia Sari. "Effect of Compensation, Motivation and Work Environment on Employee Work Productivity PT Jia Lin Wood". International Journal of Research and Review 9, nr 9 (16.09.2022): 141–49. http://dx.doi.org/10.52403/ijrr.20220914.
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This study aims to determine and analyze the effect of compensation, motivation and work environment on employee work productivity. The research location is in PT Jia Lin Wood Deli Serdang, North Sumatra. The sample of this study was 78 employees with a multiple linear regression analysis research method and using the IBM SPSS Version 25 For Window program. The results showed partially and simultaneously that the variables of compensation, motivation and work environment had a positive and significant effect on the work productivity variable, with a percentage contribution of 44.5%. Keywords: Compensation, Motivation and Work Environment
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Rinaldi, Lorenzo, Zachary L. Skidmore, Bahar Alipanahi, Garrett Graham, Bryan Chesnick, Nobuyuki Takahashi, Rajesh Kumar i in. "Dissecting small cell lung cancer subtypes with cell-free DNA fragmentomes." Journal of Clinical Oncology 41, nr 16_suppl (1.06.2023): 8592. http://dx.doi.org/10.1200/jco.2023.41.16_suppl.8592.
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8592 Background: Although small cell lung cancer (SCLC) is managed as a single cancer type, new evidence supports that subtypes (high vs low neuroendocrine) of SCLC acquire diverse transcriptional and epigenetic states. Furthermore, distinct SCLC subtypes acquire unique therapeutic vulnerabilities, such as the low-neuroendocrine highly inflamed SCLC subtype that has been linked to immunotherapy sensitivity. We have previously shown that DELFI (DNA evaluation of fragments for early interception) can be used to non-invasively distinguish SCLC from non-small cell lung cancer (NSCLC). Here, we report a preliminary analysis of using the DELFI approach for distinguishing among SCLC subtypes. Methods: Circulating cell-free DNA (cfDNA) was isolated from plasma samples of patients diagnosed with relapsed SCLC and treated with durvalumab plus olaparib in a phase II trial (NCT02484404). Over 200 cfDNA libraries were prepared for whole genome sequencing in batches with internal controls. To infer tumor gene expression profiles in cfDNA, we investigated genome-wide signals of tissue-specific transcription factors differentially regulated in SCLC, and applied a novel DELFI-based approach to inform SCLC molecular subtypes. Clinical information, patient-matched tissue transcriptome (RNA-seq), and chromatin accessibility data (ATAC-seq) were examined in orthogonal analyses. Results: The DELFI classifier detected SCLC cases (N = 47) with a median DELFI score of 1.0 (95% CI 0.99-1), significantly higher than previously reported scores for other lung cancer subtypes. Comparison of DELFI fragmentome signals to publicly available tumor transcriptomes shows subtype-level concordance ( r = 0.78, p < 0.001, Pearson), particularly in pre-treatment SCLC cases separating high- vs low- neuroendocrine subtypes. High-neuroendocrine SCLCs exhibited a decrease in aggregate cfDNA fragment coverage at ASCL1 transcription factor binding sites relative to low-neuroendocrine SCLCs (r = 0.90, p < 0.001, Pearson). Additionally, low-neuroendocrine SCLCs revealed a significant decrease in aggregate cfDNA fragment coverage at genomic binding sites regulated by hematopoietic transcription factors, reflecting the inflamed phenotype of this SCLC subtype. Integration of these approaches provided a cfDNA fragmentation-based machine learning model that distinguished SCLC subtypes with high performance. Conclusions: Genome-wide cfDNA fragmentome analyses can differentiate high- and low-neuroendocrine SCLC subtypes. Given the challenges for performing SCLC biopsies in a clinical setting, we believe this approach could be a viable method of subtyping SCLC in a non-invasive manner.
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kim Young Jin. "A Study on the Sectarian Differences and Their Historical Developments in Tazia Processions of Delhi". Journal of Indian Studies 19, nr 1 (maj 2014): 1–38. http://dx.doi.org/10.21758/jis.2014.19.1.1.
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Seth, T., A. Kotwal i R. Thakur. "Understanding factors which influence tobacco (smoking and smokeless) in secondary school children in Delhi (India)". Journal of Clinical Oncology 22, nr 14_suppl (15.07.2004): 1024. http://dx.doi.org/10.1200/jco.2004.22.90140.1024.
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DA Silva, Angélique, Aude Flechon, Stephane Culine, François Planchamp, Thibaut Murez, Arnaud Mejean, David Pasquier, Karim Fizazi i Florence Joly. "Localized testicular germ cell tumor surveillance: A Delphi consensus study." Journal of Clinical Oncology 38, nr 15_suppl (20.05.2020): e17060-e17060. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e17060.
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e17060 Background: Stage I testicular germ cell tumor (TGCT) has excellent cure rates and surveillance is fully included in patient’s management, particularly during the first years of follow-up. Surveillance guidelines differ between the scientific societies, with different recommendations concerning clinical and imaging frequency de-escalation and long term follow-up. We evaluated surveillance practice and schedules followed by French specialists and set up a DELPHI method to obtain a consensual surveillance program with an optimal schedule for patients with localized TGCT. Methods: An online survey on surveillance practice of stage I TGCT based on clinical-cases was conducted among urologists, radiotherapists and oncologists. Results were compared to AFU, ESMO and EAU guidelines. Then a panel of experts assessed surveillance proposals following a formal consensus method (DELPHI method). Statements were drafted after analysis of the previous survey and systematic literature review, with 2 successive rounds to reach a consensus. Results: Survey and DELPHI method were conducted between July 2018 and May 2019. 61 participated to the survey (69% oncologists, 15% urologists, 16% radiotherapists). About 65% of practitioners followed clinico-biological guidelines concerning 1 to 5 years of follow-up, only 25% discontinued surveillance after the 5th year, as recommended. No physician followed the ESMO guidelines of de-escalation chest imaging. A panel of 32 experts (78% oncologists, 16% urologists, 6% radiotherapists) was asked about 38 statements. Consensus was reached for 26 statements concerning clinico-biological surveillance modalities and end of surveillance after the 5th year of follow-up. For seminoma, abdominal ultrasound was proposed as an option to the abdominopelvic (AP) scan for the 4th year of follow-up. No consensus was reached regarding de-escalation of chest imaging. Conclusions: The survey proved that French TGCT specialists do not follow current guidelines. With DELPHI method, a consensus was obtained for frequency of clinico-biological surveillance, discontinuation of surveillance after the 5th year and discontinuation of AP scan on the 4th year of follow-up for seminoma. Questions remains concerning type and frequency of chest imaging.
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Falbo, Kierra Jean, i John Brinkmann. "Characteristics of Delphi Processes in Orthotics and Prosthetics Research". JPO Journal of Prosthetics and Orthotics 32, nr 3 (15.11.2019): 161–74. http://dx.doi.org/10.1097/jpo.0000000000000287.
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DA Silva, Angélique, Aude Flechon, Stephane Culine, Elodie Coquan, Antoine Thiery Vuillemin, François Planchamp, Thibaut Murez i in. "Localized testicular germ cell tumor (TGCT) surveillance: A Delphi consensus study." Journal of Clinical Oncology 39, nr 6_suppl (20.02.2021): 384. http://dx.doi.org/10.1200/jco.2021.39.6_suppl.384.
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384 Background: Stage I testicular germ cell tumor (TGCT) has excellent cure rates and surveillance is fully included in patient’s management, particularly during the first years of follow-up. Surveillance guidelines differ between the academic societies, with different recommendations concerning clinical and imaging frequency de-escalation and long term follow-up. We evaluated surveillance practice and schedules followed by French specialists and set up a DELPHI method to obtain a consensual surveillance program with an optimal schedule for patients with localized TGCT. Methods: An online survey on surveillance practice of stage I TGCT based on clinical-cases was conducted among urologists, radiotherapists and oncologists. Results were compared to AFU, ESMO and EAU guidelines. Then a panel of experts assessed surveillance proposals following a formal consensus method (DELPHI method). Statements were drafted after analysis of the previous survey and systematic literature review, with 2 successive rounds to reach a consensus. Results: Survey and DELPHI were conducted between July 2018 and May 2019. Sixty-one (12.2%) participated to the survey (69% oncologists, 15% urologists, 16% radiotherapists). For the first 5 years of follow-up we observed 30 to 50% of adherence to AFU’s guidelines, 20 to 36% of adherence to ESMO’s guidelines and 6 to 45% of practices not corresponding to any of the guidelines depending on clinical situations. Only 25% of practitioners stopped surveillance after the 5th year, as recommended. No physician followed the ESMO guidelines of de-escalation chest imaging. For the Delphi study, a panel of 32 experts (78% oncologists, 16% urologists, 6% radiotherapists) was asked about 38 statements. Consensus was reached for 26 statements concerning clinico-biological surveillance modalities and end of surveillance after the 5th year of follow-up. For seminoma, abdominal ultrasound was proposed as an option to the abdominopelvic (AP) scan for the 4th year of follow-up. No consensus was reached regarding de-escalation of chest imaging. Conclusions: The survey proved that French TGCT specialists do not follow current guidelines. With DELPHI method, a consensus was obtained for frequency of clinico-biological surveillance, discontinuation of surveillance after the 5th year and stop of AP scan on the 4th year of follow-up for seminoma. Questions remains concerning type and frequency of chest imaging.
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Garcia-Foncillas, Jesus, Juan Jesus Cruz Hernandez, Virginia Arrazubi, Yolanda Escobar, Almudena García Castaño, Juan J. Grau, Lara Iglesias i in. "Measures to evaluate quality of care in head and neck cancer: Results of a Delphi study." Journal of Clinical Oncology 40, nr 28_suppl (1.10.2022): 358. http://dx.doi.org/10.1200/jco.2022.40.28_suppl.358.
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358 Background: Currently, no specific measures are used in Spain to evaluate quality of care in head and neck cancer, and programs such as the Quality Oncology Practice Initiative developed by the American Society of Clinical Oncology does not include head-and-neck-specific measures. Methods: A systematic literature review was carried out to identify measures useful for evaluating quality of care in head and neck cancer. A scientific committee, comprising 9 medical oncologists specialized in head and neck cancer, reviewed the literature findings and developed measures to be evaluated in a 2-step Delphi method. Experts in head and neck cancer practicing in Spain—specialized in medical oncology, radiotherapy oncology, maxillofacial surgery, pathology or otorhinolaryngology—participated in the Delphi, scoring the appropriateness of the measures using a 9-point Likert scale (1, extremely inappropriate; 9, extremely appropriate). Consensus was defined as at least two-thirds of Delphi respondents selecting a score sub-category (1–3, 4–6, or 7–9) that encompassed the median score of the group. Results: Out of the 833 documents found with the literature review, 20 were selected from to identify measures of interest. Fifty measures, covering diagnosis (13), treatment (28), follow-up (5), and outcome (4), were evaluated with the Delphi method. The 52 Delphi participants reached consensus on the appropriateness of using all 50 measures to evaluate the quality of care in head and neck cancer. Measures with lowest scores concerned re-hospitalization shortly after surgery and long hospitalization after surgery. Measures with highest scores regarded the use of imaging for follow-up, a histology study prior to treatment, and complete resection of the tumor. The scientific committee then selected 29 measures based on their applicability and cost-effectiveness and developed index cards with definitions, formulas, acceptable level of attainment, and rationale for their use in clinical practice. Conclusions: The goal of this study was to develop measures to evaluate and improve the quality of care in head and neck cancer. These results show unanimous consensus from a group of experts on the proposed measures for diagnosis, treatment, follow-up, and outcome. The index cards developed with measures are easy to follow and their use could improve quality of care.
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Zapata, Gisela P. "KELEGAMA S (ed.). 2011.Migration, Remittances and Development in South Asia. (New Delhi: Sage, pp. 346)". Journal of International Development 24, nr 7 (13.09.2012): 950–51. http://dx.doi.org/10.1002/jid.2834.
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Zepke, Nick. "Thinking strategically in response to New Zealand's tertiary education strategy: The case of a Wānanga". Journal of Management & Organization 15, nr 1 (marzec 2009): 110–21. http://dx.doi.org/10.5172/jmo.837.15.1.110.
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AbstractThis paper describes commissioned research on how a Wānanga, a Maori focused post school institution in New Zealand, perceived its strategic options following the publication of the Labour-led government's Tertiary Education Strategy 2007–2012 and the Statement of Education Priorities 2008–10 (Ministry of Education 2006). The research used a Delphi panel process that looks for consensus answers to specific research questions: How should the Wānanga respond to the policies sketched in the Tertiary Education Strategy and the Statement of Education Priorities? What is the range of issues that may need to be addressed as a result of this new policy framework? What options does the Wānanga have in addressing these issues? The Delphi process enabled a clear set of priorities to be established: provide quality teaching and learning reflecting Māori values and practices; develop a consistent internal philosophy based on tikanga and āhuatanga Māori; and provide second chance education for Māori and other learners.
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Hensley Alford, Sharon, Rishi Kumar Gupta, Nayan Sonawane, Srishti Mahatma, Shilpa Mahatma i Tarun Kumar. "An innovative approach to manage cancer patient information for care coordination and monitoring using a digital health platform for a nonprofit tertiary cancer care institute in India." Journal of Clinical Oncology 38, nr 15_suppl (20.05.2020): e14102-e14102. http://dx.doi.org/10.1200/jco.2020.38.15_suppl.e14102.
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e14102 Background: In India, most patients maintain a personal copy of their medical record in paper form which is hard to manage and collate. Newly diagnosed cancer patients and their doctors have an insurmountable task of consuming and using that information. Making this information available in an easy to consume format as well as recording a patient’s cancer experience is a technical challenge. We piloted an innovative mobile application to address this pain point. Methods: A pilot engagement was performed with 100+ cancer patients visiting a non-profit oncology center between March 2019 and January 2020 in a suburb of New Delhi, India. Systematic medical information was captured on stage, TNM, molecular markers, tumor size, tests, and treatments. We assessed the utility of a digital health application for the purpose of cancer information management and ease of use by the medical team. Results: Data for a total of 65 patients with a single cancer and diagnosis and treatment information was captured. Patients were between the ages of 23 and 78, mean age 49. Of these patients, there were 21 (32%) early stage cases ( < Stage 3), 23 (35%) late stage cases ( > Stage 2), and 21 (32%) cases with missing stage. Overall, 39 (60%) received a chemotherapy only regimen, 2 (3%) radiation only, 6 (9%) surgery only, 6 (9%) received chemotherapy and radiation, 11 (17%) received surgery and chemotherapy, and 1 (1%) patient received surgery, chemotherapy, and radiation. Clinic staff reported that the application was easy to use and helpful. We continue to enhance the application with staff feedback. Conclusions: We demonstrate the feasibility and value of moving to a next generation digitized mobile platform circumventing the need for a traditional EMR system at a busy non-profit oncology clinic in the suburbs of New Delhi, India. Using the pilot, we make a case that this type of technology has the ability to transform cancer care for rural and low-resource cancer centers. We also demonstrate that it is easy to capture patient longitudinal data using this innovative platform.
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Jacek Kozak, Krištof. "Disput o petih paradoksih »poezije stranišča« s prologom in epilogom". Amfiteater 11, nr 1 (30.06.2023): 202–15. http://dx.doi.org/10.51937/amfiteater-2023-1/202-215.
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Med deli verjetno najboljšega poznavalca slovenske dramatike in njenega prvega teoretika Tarasa Kermaunerja je mogoče najti tudi en sam dramski poskus: sodno razpravo o vrednosti avantgardistične poezije na primeru obtoženega pesnika Tomaža Šalamuna. Sicer gledališko zelo uporabno zvrst sodnega disputa Kermauner zanimivo razvije, zaključi pa jo s popolnoma antidramskim, antiklimaktičnim sklepom, s katerim preloži odločanje o stvari na drugi časoprostor. Natančnejši pregled besedila razkrije različne konceptualne nedoslednosti, ki jih je mogoče zajeti s pojmom paradoksa. V tekstu je bilo tako mogoče izslediti pet točk, ki bi jih bilo mogoče definirati kot paradoksne, in sicer zadevajo vsebinske kategorije, kot so bistvo umetnosti, vprašanja naroda za umetnost, umetnosti in marksizma ter življenja kot vrhovne estetske kategorije, zadnji paradoks pa je formalen, saj sodna razprava s svojim zaključkom izzveni popolnoma v prazno: ne glede na dovolj izrazito in ostro predstavitev stališč obeh protagonistov, Toživca in Branivca, se Kermauner odloči – namesto za stopnjevanje konflikta do (gledališkega) vrhunca – za razvodenitev disputa na podlagi vključitve občinstva in ugotovitve, da se slednje v vlogi porote ne more odločiti za nobeno od strani. (Raz)rešitev dileme o (nacionalni, umetniški) kvaliteti avantgardistične poezije tako preostane – vsej pirotehniki Kermaunerjeve gledališke sodne razprave navkljub – prihodnosti in literarni teoriji.
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Kozak, Krištof Jacek. "Disput o petih paradoksih »poezije stranišča« s prologom in epilogom". Gledališke in medumetnostne raziskave 11, nr 1 (30.06.2023): 202–2015. http://dx.doi.org/10.51937/amfiteater_2023_1/202-215.
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Med deli verjetno najboljšega poznavalca slovenske dramatike in njenega prvega teoretika Tarasa Kermaunerja je mogoče najti tudi en sam dramski poskus: sodno razpravo o vrednosti avantgardistične poezije na primeru obtoženega pesnika Tomaža Šalamuna. Sicer gledališko zelo uporabno zvrst sodnega disputa Kermauner zanimivo razvije, zaključi pa jo s popolnoma antidramskim, antiklimaktičnim sklepom, s katerim preloži odločanje o stvari na drugi časoprostor. Natančnejši pregled besedila razkrije različne konceptualne nedoslednosti, ki jih je mogoče zajeti s pojmom paradoksa. V tekstu je bilo tako mogoče izslediti pet točk, ki bi jih bilo mogoče definirati kot paradoksne, in sicer zadevajo vsebinske kategorije, kot so bistvo umetnosti, vprašanja naroda za umetnost, umetnosti in marksizma ter življenja kot vrhovne estetske kategorije, zadnji paradoks pa je formalen, saj sodna razprava s svojim zaključkom izzveni popolnoma v prazno: ne glede na dovolj izrazito in ostro predstavitev stališč obeh protagonistov, Toživca in Branivca, se Kermauner odloči – namesto za stopnjevanje konflikta do (gledališkega) vrhunca – za razvodenitev disputa na podlagi vključitve občinstva in ugotovitve, da se slednje v vlogi porote ne more odločiti za nobeno od strani. (Raz)rešitev dileme o (nacionalni, umetniški) kvaliteti avantgardistične poezije tako preostane – vsej pirotehniki Kermaunerjeve gledališke sodne razprave navkljub – prihodnosti in literarni teoriji.