Artykuły w czasopismach: „Jinkaku”

1

Nishikawa, Yumeno Grace. "Japanese Climate Litigation and the Development of Personal Rights". Chinese Journal of Environmental Law 7, nr 2 (14.12.2023): 214–26. http://dx.doi.org/10.1163/24686042-12340106.

Pełny tekst źródła

Streszczenie:

Abstract Since climate change was recognised as a global concern, there has been a growing number of climate-related cases around the world. While the development of climate litigation in Japan is often overlooked in the academic literature, Japanese citizens in fact have instituted four lawsuits that all aim to stop the construction and operation of coal-fired power plants, as the use of coal in the power generation sector is primarily responsible for the total emissions of greenhouse gases in Japan. Accordingly, this article aims to introduce the recent climate-related cases and to show how human rights-based concepts are utilized with the intention of incorporating environmental claims. More specifically, the development of the concept of personal rights (Jinkaku-ken, 人格権) is discussed, primarily by examining the arguments made in the tort law-based climate cases.

Style APA, Harvard, Vancouver, ISO itp.

2

Inoue, Kyoko. "The origin and the development of the concept Jinkaku—an important concept in Japanese morality". Language Sciences 21, nr 3 (lipiec 1999): 265–81. http://dx.doi.org/10.1016/s0388-0001(98)00028-x.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

3

Orr, James J. "Reviews of Books:Individual Dignity in Modern Japanese Thought: The Evolution of the Concept of Jinkaku in Moral and Educational Discourse Kyoko Inoue". American Historical Review 108, nr 3 (czerwiec 2003): 809. http://dx.doi.org/10.1086/529614.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

4

HORVAT, Andrew. "Bushidō and the Legacy of “Samurai Values” in Contemporary Japan". Asian Studies 6, nr 2 (29.06.2018): 189–208. http://dx.doi.org/10.4312/as.2018.6.2.189-208.

Pełny tekst źródła

Streszczenie:

Though difficult to define as a clear set of moral precepts, aspects of so-called “samurai values”, the combination of orally-transmitted Confucian and Buddhist lore to which Nitobe Inazō refers in his Bushido, can clearly be discerned in Japanese society today. As evidence for the influence of “samurai values”, I have provided examples from two fields with which I am personally familiar: journalism and education. Although in recent years several academic works have exposed historical anomalies in widely-held beliefs about actual samurai behaviour, I argue that the effectiveness of ideologies does not depend on historical accuracy. For example, justification for the right of newspapers to criticise governments in Japan does not stem from inalienable rights originating with European Enlightenment philosophers. Instead, it is linked to the view that the former samurai who in the 1870s became Japan’s first news reporters could be trusted intermediaries between the government and the people, because as samurai they possessed higher standards of morality. That expectations of superior moral conduct continue to justify in the eyes of the general public the right of newspapers to speak truth to power can be seen by mass cancellations of subscriptions of newspapers whose staff betray these expectations through involvement in scandal. Likewise, the emphasis on “character building” (jinkaku keisei) in Japanese higher education is another link to perceived “samurai values.” Some of Japan’s leading private universities were founded in the late nineteenth century by former samurai. As in the case of journalism, the maintenance of superior moral conduct helps strengthen the claim to legitimacy of educational institutions in Japan. Finally, I will present a picture of Nitobe as an example of a former samurai who long after his passing continues to be revered for having adhered to the “samurai values” he both defined and embraced.

Style APA, Harvard, Vancouver, ISO itp.

5

Mathews, Gordon. "Japan's Alternative Modernity in a Globalizing World:Japan and Its Others: Globalization, Difference, and the Critique of Modernity.;Individual Dignity in Modern Japanese Thought: The Evolution of the Concept of Jinkaku in Moral and Educational Discourse.;Hegemony of Homogeneity: An Anthropological Analysis of Nihonjinron." American Anthropologist 104, nr 3 (wrzesień 2002): 958–61. http://dx.doi.org/10.1525/aa.2002.104.3.958.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

6

SASAMOTO-COLLINS, HIROMI. "KYOKO INOUE: Individual dignity in modern Japanese thought: the evolution of the concept of jinkaku in moral and educational discourse. (Michigan Monograph Series in Japanese Studies, 35.) xi, 262 pp. Ann Arbor: Center for Japanese Studies, The University of Michigan, 2001. £37.50." Bulletin of the School of Oriental and African Studies 65, nr 2 (czerwiec 2002): 379–487. http://dx.doi.org/10.1017/s0041977x02780154.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

7

Souza, Fabíola Amaral Tomé de. "Experiências sociais no campo afro-religioso: a vida de Mameto Iraê Jinkaiá. * Social experiences in the afro-religious field: the life of Mameto Iraê Jinkaiá." História e Cultura 6, nr 3 (29.12.2017): 193. http://dx.doi.org/10.18223/hiscult.v6i3.2176.

Pełny tekst źródła

Streszczenie:

Esse trabalho pretende contribuir para o campo da história das mulheres, através da trajetória de vida de Mameto Iraê Jinkaiá, ex mãe-de-santo de uma casa de candomblé nação Angola no município de Barra Mansa, sul do estado do Rio de Janeiro. Utilizando condicionantes estruturais que marcam a vida e as experiências dos agentes históricos, entendendo que a trajetória de um indivíduo pode ser substancial para contextualizar certa dimensão histórica, através de uma metodologia qualitativa de análise micro histórica e gênero como categoria analítica, buscando ampliar a ideia dos papéis sociais pensando as relações de poder. Ou seja, pensar a mulher enquanto liderança religiosa e demonstrando que o poder atribuído às mulheres do candomblé não está centrado nas grandes capitais, símbolos das religiões afro-brasileiras, como Salvador, Rio de Janeiro, São Paulo ou Porto Alegre. Palavras-chave: História das Mulheres, relações de gênero, candomblé.

Style APA, Harvard, Vancouver, ISO itp.

8

Amaje, Elias, Feleke Gebremeskel, Girma Tufa, Miesa Gelchu i Zelalem Jabessa Wayessa. "Colostrum Avoidance Practices and Its Associated Factors among Mothers of Children Aged Less Than 12 Months in Jinka Town, South Ethiopia, 2020. A Community Based Cross Sectional Study". Health Services Research and Managerial Epidemiology 9 (styczeń 2022): 233339282211060. http://dx.doi.org/10.1177/23333928221106056.

Pełny tekst źródła

Streszczenie:

Background Even though colostrum discarding hurts child health, little is known about the extent of the problem and its contributing factors in Southern Ethiopia. This study aimed to determine the prevalence of colostrum avoidance practices and associated factors among mothers of children aged less than 12 months in Jinka town, South Ethiopia. Methods A community-based cross-sectional study was conducted at Jinka Town from March 1 to 30, 2020. A total of 420 mothers having children less than 12 months of age were selected by systematic sampling technique. The data were collected by using pretested interviewer-administered and semi-structured questionnaires. The data was entered using EPI DATA 3.1 and exported to SPSS version 23 for analysis. Descriptive statistics, binary and multivariable logistic regression analysis were done. Adjusted odds ratio with 95% CI at a p-value < 0.05 was estimated to identify statistically significant variables with colostrum avoidance practices. Results The prevalence of colostrum avoidance practice was 9.8% [95% CI: (6.9–12.5)]. Delayed initiation of breastfeeding [AOR = 9.08(95% CI 4.16–19.83)], lack of breastfeeding counseling [AOR = 2.33(95% CI 1.11–4.87)], home delivery of index child [AOR = 2.48 (95% CI 1.16–5.27)] and poor knowledge on breastfeeding [AOR = 4.55(95% CI 1.95–10.63)] were factors associated with colostrum avoidance practices. Conclusion Colostrum avoidance practice among mothers of children aged less than 12 months in Jinka town was high. Delayed initiation of breastfeeding, lack of breastfeeding counseling, home delivery, and knowledge of breastfeeding practice were factors associated with colostrum avoidance practice.

Style APA, Harvard, Vancouver, ISO itp.

9

Shi, Zhao Zhong, Yu Rong Yang i Ling Zhang. "Reach the Target of Promoting Energy Saving and Emission Cutting by Clean Development Mechanism". Advanced Materials Research 233-235 (maj 2011): 403–6. http://dx.doi.org/10.4028/www.scientific.net/amr.233-235.403.

Pełny tekst źródła

Streszczenie:

Clean development mechanism is one way of cooperation between developed and developing countries to decrease greenhouse gases emission in the “Kyoto Protoco1”. An advanced technology of Japan Mitsubishi Corporation was introduced to Kaifeng Jinkai Chemical Engineering to reduce the emission of N2O by improving nitric acid production installation. This can not only reduce the greenhouse gases emission, reduce nitric acid production costs and create considerable economic efficiency to enterprise but also promote clean development mechanism and make great contribution to the world environmental protection.

Style APA, Harvard, Vancouver, ISO itp.

10

Tesema, Kassahun Fikadu, Tamirat Cheneka, Alemayehu Alemu, Mekonen Feyissa, Birhanu Birkaye, Hafiza Mohammed, Eleni Kidu, Getahun Wegaso i Biresaw Wasihun. "Knowledge of Preconception Healthcare and Associated Factors: A Study among Mothers in Jinka Town, Southern Region, Ethiopia". Scientific World Journal 2021 (28.02.2021): 1–10. http://dx.doi.org/10.1155/2021/7529805.

Pełny tekst źródła

Streszczenie:

Background. Preconception healthcare is promising to improve the reproductive health status of women and couples if they receive care three months to two years before conception. In the current context of Ethiopia, however, preconception healthcare is overlooked in the continuum of care. Therefore, this study aimed to assess the knowledge of preconception healthcare and associated factors: a study among mothers in Jinka town, southern region, Ethiopia. Methods. A community-based cross-sectional study was employed among 522 randomly selected women of childbearing age who are living in Jinka town from March to April 2018. The study considers all the kebeles in the town. Study subjects were determined using proportionate-to-population size allocation. Then, a systematic random sampling technique was applied. Data were collected using a semistructured and pretested questionnaire. Descriptive summary data and binary logistic regression analysis were carried out to identify factors with the 95% confidence level and a p value of less than 0.05. Results. A total of 513 study subjects participated in this study. The overall preconception healthcare knowledge score of women in Jinka town was 51.1%. In the multivariable analysis, housewives (AOR = 2.93; 95% CI: 1.38–6.19), an education level of at least college (AOR = 3.79; 95% CI: 1.75–8.23), no history of neonatal death (AOR = 4.13; 95% CI = 1.39–12.25), and the use of family planning methods (AOR = 2.38; 95% CI: 1.49–3.79) increased the probability of preconception healthcare knowledge compared to the counterparts. Conclusion. In this study, women’s knowledge of preconception healthcare was found borderline. The identified factors were housewife, education level of at least college, no history of neonatal death, and using family planning methods. Therefore, emphasizing these factors for the enhancement of women’s knowledge of preconception healthcare is a necessary step.

Style APA, Harvard, Vancouver, ISO itp.

11

Yetwale, Aynalem, i Eneyew Melkamu. "Fear of Childbirth and Associated Factors Among Pregnant Mothers Who Attend Antenatal Care Service at Jinka Public Health Facilities, Jinka Town, Southern Ethiopia". International Journal of Childbirth 11, nr 3 (1.06.2021): 101–11. http://dx.doi.org/10.1891/ijcbirth-d-20-00029.

Pełny tekst źródła

Streszczenie:

BACKGROUNDWomen face many challenges from conception to postpartum, and fear of childbirth is one of the challenges the women encounter during pregnancy. This could have resulted from different perspectives and it could in turn lead to various pregnancy and childbirth problems. Thus, understanding childbirth fear and factors associated with this is of paramount importance and this study was aimed at addressing this issue.METHODOLOGYA facility-based cross-sectional study was done on 423 pregnant mothers who came for antenatal care services at Jinka hospital and Jinka health center. The study was conducted from June 1to 30, 2018. The sample size was calculated using the single population proportion formula and samples were taken after proportional allocation was done for the hospital and health center using the proportion allocation formula. Individual participants were selected with a systematic sampling technique using k-value of 2 for both the hospital and health center and the first participant was selected by the lottery method from the first two samples. Data were entered into epi-data version 3.1.1. and exported into statistical packages for social sciences version 21.0 for cleaning and further analysis. The level of significance was declared at a p value of less than 0.05 in multivariable logistic regression model. Narratives, figures, and tables were used to put the result.RESULTFrom 423 samples, two of the questionnaires were incomplete and thus 421 were used for analysis giving a response rate of 99.5%. Around a quarter of 102 (24.2%) mothers had fear of childbirth and the remaining 319 (75.8%) had no fear of childbirth. From the factors under consideration, history of previous pregnancy complications, previous history of labor and delivery complications, educational status, and depression status were significantly associated with a mother's fear of childbirth.CONCLUSIONEven though it is physiological to have some fear of childbirth, the figure obtained is relatively higher. Factors found to have a significant effect on childbirth fear are those which could be tackled through improved health literacy and integrated maternal health services.

Style APA, Harvard, Vancouver, ISO itp.

12

Gezahegn, Biruk, Awoke Tadesse, Anteneh Tadesse i Zeynu Kelifa. "Effect of cassava legumes intercropping on yield and yield components of compound crops in Jinka on station, Southern Ethiopia". International Journal of Agricultural Research, Innovation and Technology 12, nr 1 (23.08.2022): 30–33. http://dx.doi.org/10.3329/ijarit.v12i1.61028.

Pełny tekst źródła

Streszczenie:

A field experiment was carried out during the 2017-18 cropping season at Jinka Agricultural Research Center on station, South Omo zone, Southern Ethiopia, to determine suitable legumes in cassava legume intercropping on yield and land use efficiency of both crops. The experiment consisted of 7 treatments (cassava with haricot bean, cowpea, and pigeon pea as intercrop compared with cassava, haricot bean, cowpea and pigeon pea as sole) laid in RCBD in three replications. Statistical analysis showed that, intercropping cassava with haricot bean, cowpea and pigeon pea resulted in 54, 56 and 21% greater land use efficiency than for either crop grown alone. The highest MAI was obtained by growing cassava with haricot bean (18310.8) followed by cassava with cowpea (14524.4) whereas relatively the lowest was cassava with pigeon pea (6005.6). Based on the present finding, intercropping of cassava with haricot bean had more economic advantage (52219.8 Ebirr) than the other crop combination or grown alone. Therefore, intercropping cassava with grain legumes such as haricot bean and cowpea is important to cassava farmers since it would provide additional crop yield during the early cassava growth stage with the same piece of land and more profitable related to cost benefit. Therefore, use of cassava intercropping with haricot bean can be recommended for cassava producing farmers at Jinka and its vicinity. Int. J. Agril. Res. Innov. Tech. 12(1): 30-33, June 2022

Style APA, Harvard, Vancouver, ISO itp.

13

Mitiku, Misgana, i Awoke Tadesse. "ADAPTABILITY STUDY OF IMPROVED ONION (ALLIUM CEPA L.) VARIETIES AT SOUTH ARI WOREDA OF SOUTH OMO ZONE, ETHIOPIA". International Journal of Research -GRANTHAALAYAH 5, nr 7 (31.07.2017): 541–45. http://dx.doi.org/10.29121/granthaalayah.v5.i7.2017.2162.

Pełny tekst źródła

Streszczenie:

Onion varieties were evaluated for adaptability to the climatic conditions in South Ari woreda. Three varieties of onion were planted under a complete randomized block design experiment with three replications at research field in Jinka Agricultural research Center (South Ari woreda of South Omo zone SNNPRS of Ethiopia). The quantitative data on bulb yield, plant height, bulb size and number of leaves of onion varieties were collected. All the varieties were harvested at their maturity (90% tops down) and then weighed. Statistical methods were used for data analysis where by analysis of variance was applied. It was concluded that the three varieties (treatment) combinations, namely Adama red, Nasick red and contribute similarly to the total yield, plant height, number of leaves and bulb size. The variety local was the best onion variety as it produced the highest bulb yield of 3.3167 kg/plot numerically. Based on varietal characteristics of relative bulb size, good yield, easy availability of seeds and cheaper price of seeds in the local market, we recommend farmers to use local variety followed by Nasick red and Adama red therefore, government should promote these onion varieties for cultivation in South Ari especially for jinka and its vicinity. Government can import to ensure the availability of Local and Nasick red varieties so that farmers can be motivated for adoption of these varieties for commercial production. The effects of different planting dates on the yield of onion varieties can be considered for future research.

Style APA, Harvard, Vancouver, ISO itp.

14

Getachew, Ashagire, Melat Woldemariam, Addis Aklilu, Aseer Manilal, Mohammedaman Mama, Biresaw Wasihun i Tesfaye Kanko. "Prevalence of Syphilis and Human Immunodeficiency Virus Among Pregnant Women Attending Antenatal Care Clinic In Jinka General Hospital, Southern Ethiopia from 2015-2017.A Retrospective Study". OMO International Journal of Sciences 4, nr 1 (25.06.2021): 34–49. http://dx.doi.org/10.59122/134f985.

Pełny tekst źródła

Streszczenie:

Sexually transmitted infections are a major public health issue. Syphilis and HIV are the leading STIs highly prevalent in sub-Saharan African countries including Ethiopia, which can have a critical impact on reproductive, maternal, and newborn health such as stillbirth. Therefore, this study was aimed to assess the seroprevalence of syphilis and HIV among pregnant women who attended antenatal care clinics in Jinka General Hospital, South Omo, Ethiopia. A retrospective cross-sectional study was carried out in Jinka General Hospital from 2015 to 2017. Data were obtained from individual charts and laboratory logbooks using a structured checklist. Statistical package for social sciences version 21 was used to analyze the data. Finally, the results were presented in text, tables, and graphs. A total of 1712 pregnant women attended antenatal care clinics between 2015 and 2017. The seroprevalence of syphilis and HIV were found to be 18 (1.05%) and 70(4.0%) respectively. Most of the syphilis seropositive cases were observed among married pregnantwomen 13(72.22%) in the age group of 20-30 14(77.78%). Syphilis and HIV co-infection was found in 14 (0.82%) subjects. The trend of syphilis infection peaked from 0.41% in 2015 to 1.48% in 2016 but declined to 1.16% in 2017. A downward trend has been observed in the case of HIV infection, wherethe prevalence rate fell steeply from 5.9% in 2015 to 1.46% in 2017. The seroprevalence of HIV and syphilis among pregnant women showed slightly high, which needs due attention with special consideration for active childbearing age women.

Style APA, Harvard, Vancouver, ISO itp.

15

Yetwale, Aynalem, Teklemariam Gultie, Dessalegn Ajema, Bezawit Afework i Semahegn Tilahun. "Prevalence of Antenatal Depression and Its Associated Risk Factors Among Pregnant Mothers Attending Antenatal Care Service at Jinka Public Health Facilities, Southern Ethiopia". International Journal of Childbirth 11, nr 2 (16.04.2021): 47–57. http://dx.doi.org/10.1891/ijcbirth-d-20-00033.

Pełny tekst źródła

Streszczenie:

BACKGROUNDAntenatal depression is the most common psychiatric disorder during pregnancy with serious consequences for the mother and the fetus. However, there are few studies about this health issue in developing countries. This study aimed to determine the prevalence of antenatal depression and its associated risk factors among pregnant mothers attending antenatal care service at Jinka public health facilities, south Omo zone, Southern Ethiopia.METHODSInstitutional-based cross-sectional study design was conducted on 446 pregnant women at Jinka public health facilities, from June 1 to June 30, 2018. Beck Depression Inventory was used to assess women's level of depression. Statistical package for social science version 20.0 was used for analysis. Logistic regression was used to find out the association between explanatory and depression. The strength of association was evaluated using odds ratio at 95% confidence interval (CI).RESULTThe magnitude of antenatal depression in this study was 24.4% (20.2–28.5 at 95% CI) and it had statistically significant association with unmarried marital status adjusted odds ratio (AOR) = 13.39 [(95% CI); (3.11–57.7)], chronic medical illness AOR = 3.97 [(95% CI); (1.07–14.7)], unplanned pregnancy AOR = 6.76 [(95% CI); (2.13–21.4)], history of abortion AOR = 2.8 [(95% CI); (1.14–7.02)], history of previous pregnancy complication AOR = 4.8 [(95% CI); (2.12–17.35)], and fear of pregnancy-related complications AOR = 5.4 [(95% CI); (2.32–12.4)].CONCLUSIONSNearly one pregnant woman develops antenatal depression in every four pregnant women. Variables like unmarried marital status, chronic medical illness and unplanned pregnancy, history of previous pregnancy complications, and fear of pregnancy-related complications were associated with antenatal depression. Therefore, it is recommended that these risks factors should be evaluated during antenatal care with a view to improving maternal health.

Style APA, Harvard, Vancouver, ISO itp.

16

Enbiale, Mulusew, Asmare Getie, Frehiwot Haile, Beemnet Tekabe i Direslgn Misekir. "Magnitude of syphilis sero-status and associated factors among pregnant women attending antenatal care in Jinka town public health facilities, Southern Ethiopia, 2020". PLOS ONE 16, nr 9 (10.09.2021): e0257290. http://dx.doi.org/10.1371/journal.pone.0257290.

Pełny tekst źródła

Streszczenie:

Introduction Syphilis is one of the leading causes of perinatal morbidity and mortality and is one of the most important public health problems. There was no study showing syphilis serostatus and its related factors among pregnant women in the current study area. This study was aimed to assess the magnitude of syphilis serostatus and associated factors among pregnant women attending antenatal care in Jinka town public health facilities. Method Institution based cross-sectional study design was conducted in Jinka town public health facilities, southern Ethiopia from the 1st July to the 1st September, 2020. A systematic sampling technique was used to select 629 study subjects. Data were collected using a structured questionnaire through face-to-face interviews and records were reviewed to check syphilis test results. Data were coded and entered by using Epi-data version 4.432 and analyzed using SPSS version 25. The binary logistic regression model was used to investigate factors associated with syphilis. A p-value of < 0.05 at multivariable analysis was considered statistically significant. Result In this study, syphilis sero-prevalence among pregnant women attending antenatal care clinics was 4.8% (95% CI: 3.12, 6.48). Rural residence [AOR: 2.873; 95%CI (1.171, 7.050)], alcohol use [AOR: 3.340; 95% CI (1.354, 8.241)] and having multiple sexual partner [AOR: 5.012; 95% CI (1.929, 13.020)] were statistically significantly associated with syphilis. Conclusion Sero-prevalence of syphilis was high. Being a rural residence, having multiple sexual partners, alcohol use were factors associated with syphilis. Therefore, substantial efforts have to be made to provide regular health education for pregnant women at the antenatal clinic on the avoidance of risky behaviors and the risk of syphilis on their pregnancy.

Style APA, Harvard, Vancouver, ISO itp.

17

Girmay, Goitom, Teklemariam Gultie, Gebrekiros Gebremichael, Bezawit Afework i Gebremariam Temesgen. "Determinants of uterine rupture among mothers who gave birth in Jinka and Arba Minch General Hospitals, institution-based case–control study, Southern Ethiopia, Ethiopia, 2019". Women's Health 16 (styczeń 2020): 174550652096172. http://dx.doi.org/10.1177/1745506520961722.

Pełny tekst źródła

Streszczenie:

Background: Uterine rupture is a major public health problem in low-income countries including Ethiopia. In Ethiopia, its prevalence is low, but it results in devastative health problems of the mother and her baby. Even though the Ethiopian government and nongovernmental organizations tried to strengthen the health care system, significant adverse maternal and fetal outcome is still associated with uterine rupture. The aim of this study was to identify determinants of uterine rupture in Jinka and Arba Minch General Hospitals. Methods: The study was conducted in Jinka and Arba Minch General Hospitals, and the data collection period was 15 to 30 November 2018. A case–control study design was used with simple random sampling of 1:4. Data were collected using data extraction sheets. Variables with p < 0.25 in bivariate logistic regression were entered into multivariable logistic regression. Variables with p < 0.05 in multivariable logistic regression were used to determine significant association between dependent and independent variables. Result: Uterine rupture occurred in 112 cases with 448 controls. Women referred from health facilities (adjusted odds ratio = 8.0, 95% confidence interval: 3.5–17.8), multiparous women (adjusted odds ratio = 12.7, 95% confidence interval: 4.2–39.0), duration of labor more than 18 h (adjusted odds ratio = 11.5, 95% confidence interval: 5.5–24.1), malpresentation (adjusted odds ratio = 3.5, 95% confidence interval: 1.0–8.0) and gestational age of ⩾37 weeks (adjusted odds ratio = 5.2, 95% confidence interval: 1.4–19.3) were independent factors associated with uterine rupture. Conclusion: Mothers referred from health facilities, multiparous women, duration of labor more than 18 h, gestational age of ⩾37 weeks and malpresentation were significantly associated with uterine rupture. Early referral, encouraging family planning, proper use of partograph, early identification and appropriate intervention for malpresentation are recommended.

Style APA, Harvard, Vancouver, ISO itp.

18

Mesele, Molalegn, Getachew Asmare, Gizachew Ambaw, Misganaw Asmamaw, Mohammed Abdu, Endeshaw Chekol, Denekew Tenaw i in. "Pregnant women's adherence to COVID-19 prevention practice and associated factors in Jinka Town, South Omo Zone, Southern Ethiopia, a community based cross-sectional study". F1000Research 13 (8.01.2024): 47. http://dx.doi.org/10.12688/f1000research.134843.1.

Pełny tekst źródła

Streszczenie:

Background Pregnancy-related coronavirus disease 2019 (COVID-19) transmission and infection rates have continued to be a top public health concern. Pregnant mothers also have a higher risk of developing serious illness, needing to be admitted to an intensive care unit, and needing mechanical ventilation. More than six million people died as a result of COVID-19 worldwide. The aim of this study was to assess the level of adherence to COVID-19 preventive practice among pregnant mothers in Jinka Town. Methods In Jinka, South Omo Zone, between January 1 and January 30, 2023, a cross-sectional study was conducted. Using a simple random sampling technique, 412 pregnant women were selected. Data were collected using a face-to-face interviewer-administered, pre-tested questionnaire. The data were entered using Epi-data version 3.1, and after being exported, were analyzed using SPSS version 25. Bivariate and multivariable logistic regression analysis was carried out to identify relevant components. An adjusted odds ratio and a 95% confidence interval were used to report the relationship between the covariates and the outcome variable. Results The percentage of participants who adhered to COVID-19 prevention measures was only 11.4% (95% CI: 8.5, 14.8). Mothers with at least a bachelor’s degree 3.71 (AOR=3.71, 95% CI=1.28, 10.73), a residency of 4.40 (AOR=4.40, 95% CI=1.96, 9.87), and a history of chronic illness of 4.30 (AOR=4.30, 95% CI=1.69, 10.93) were significantly associated with good adherence to COVID-19 prevention practices. Conclusions Only a very small percentage of pregnant women, according to this poll, adhere to COVID-19 preventative practices. In order to raise pregnant women’s awareness of COVID-19 preventive practices, it is crucial to use a variety of media for health education. Further, it is preferable to focus on urban living and give special attention to women without a formal education.

Style APA, Harvard, Vancouver, ISO itp.

19

윤도영. "The Development and Production of Jinkou Porcelain in China and Goryeo from 10th to 13th Centuries". KOREAN JOURNAL OF ART HISTORY 296, nr 296 (grudzień 2017): 33–64. http://dx.doi.org/10.31065/ahak.296.296.201712.002.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

20

Yoseph, Tekle. "Adaptability Study of Banana (Musa Paradisiacal var. Sapiertum) Varieties at Jinka, Southern Ethiopia". American Journal of Agriculture and Forestry 2, nr 6 (2014): 250. http://dx.doi.org/10.11648/j.ajaf.20140206.13.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

21

Zeleke, Eshetu Andarge, Teshale Fikadu, Muluken Bekele, Negussie Boti Sidamo i Kidus Temesgen Worsa. "Physical activity status among adolescents in Southern Ethiopia: A mixed methods study". PLOS ONE 18, nr 11 (9.11.2023): e0293757. http://dx.doi.org/10.1371/journal.pone.0293757.

Pełny tekst źródła

Streszczenie:

Background Adolescents physical activity is associated with current and future health benefits, reduction of cardio-vascular risk factors, improved bone mineral density, and mental health. The aim of the current study is to assess physical activity status and its factors among adolescents in Arba Minch and Jinka towns, Southern Ethiopia. Methods The study was conducted on 1255 randomly selected schools adolescents of Arba Minch and Jinka town by employing a mixed method. The qualitative data was obtained by Focus Group Discussion. Multiple linear regressions were done to identify factors affecting physical activity. Codes, sub-categories, and main categories were derived from the transcripts and presented in narrative ways to describe adolescent student’s perception on physical activity, its barriers and facilitators by comparing with quantitative findings. Results The mean physical activity level was 2.08 (95% CI: 2.04–2.12). A student’s self-perception about being physically active, being a member of a sport or fitness team, and engaging in after-school activity to earn money, being older, sex, a self-perception of being healthy, higher levels of vegetable and fruit consumption, having someone who encouraged physical activity, perceiving one’s family as being active, self-perception of not being overweight and attending schools that have a sports/playground were factors associated with physical activity. The qualitative finding showed a related finding. Poor awareness on the recommended physical activity, benefits of physical activity, lack of interest, restrictions from family members, peers and the community, uncomfortable environment were barriers to physical activity. Conclusion and recommendation The physical activity level of adolescents was low. Age, sex, a positive self-perception about PA and general health, and perception about one’s family PA, healthy eating practice, and the presence of role model were associated factors. Lack of self-motivation, interest and family restrictions were barriers to physical activity. PA promotion should be made by incorporating PA into school health programs and strengthening the existing school curriculum.

Style APA, Harvard, Vancouver, ISO itp.

22

Mojira, Tamene, i Samuel Dagalo. "Evaluation of Hydraulic Performance of Irrigation Scheme at Kuraz Sugar Development Project, Jinka, Ethiopia". American Journal of Mechanics and Applications 9, nr 2 (2021): 18. http://dx.doi.org/10.11648/j.ajma.20210902.12.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

23

Ali, Mukti, Isma Ayu Wulandari, Zaenal Muttaqin i Sukron Ma’mun. "The Cultural Message of Da’wah on The Jingkrak Sundang Dance in Central Java". Karsa: Journal of Social and Islamic Culture 29, nr 2 (20.12.2021): 78–99. http://dx.doi.org/10.19105/karsa.v29i2.4905.

Pełny tekst źródła

Streszczenie:

This study aims to discuss the message of da’wah that is contained in the Jinkrak Sundang Dance by using a qualitative descriptive approach and using the technique of semiotic analysis. Semiotics seeks to find the signs with meaning and know the sign systems such as language, movement, music, and pictures. As for the objects of the material to be analyzed is the movement of dance performed by the Jingkrak Sundang Dance artist, located in Magelang. A semiotic analysis on the Jingkrak Sundang Dance is performed on each stage or round: Mlayu, Nebah Bumi, Laku Telu Dadung Ngawuk, Pati, Mendem, and Nawur. Jingkrak Sundang Dance depicts the anger of the animals whose habitat was marred by the man’s hand, who was not responsible. The da’wah messages were found in denotation and connotation that many charged theological and anthropological. Theologically, the da’wah message explains the belief in the power of God as creators and regulators of whole natural life. In contrast, the da’wah message emphasizes the anthropocentric, seen many messages that urge to keep, love, and affection among fellow creatures. This study shows the conveyed to society to preserve nature and survival of all living beings. In addition, human behavior with good acts, help, and practice at once be an example for human beings and caring for the sustainability of the nature of the other.

Style APA, Harvard, Vancouver, ISO itp.

24

Li, Yue, Shuliang Zhang i Cheng Ji. "Exploring the Path of Delayed Service Education after Physical Education under the Background of “Double Reduction” Policy". Occupation and Professional Education 1, nr 1 (styczeń 2024): 38–47. http://dx.doi.org/10.62381/o242106.

Pełny tekst źródła

Streszczenie:

The “double reduction” policy leads the new development pattern of education, enhances the subject status of school physical education, and provides an important opportunity to promote the high-quality development of school physical education. As a part of school physical education, the delayed service after physical education can promote the comprehensive development of students and the growth of Jinkang. The development and implementation of delayed service after physical education class bring about the change of the ecological environment of education, and seek opportunities in the change, and then promote the high-quality development of delayed service after physical education class. This article sorts out the value implications of delayed sports after-school services under the background of the “double reduction” policy through literature review and logical analysis, and conducts in-depth analysis of the ecological transformation of sports after-school services. In the comparison of the transformation of delayed service after physical education classes, problems were found and difficulties were found: 1. Clear policy guidance and concept, but implementation was not "practical"; 2. Clear positioning of the education subject, but incomplete ability; 3. Clear thinking of the education model, but not "new" in form; 4. Clear goals of the education system, but incomplete guarantee. In response to the dilemma of delayed service after physical education classes, a collaborative implementation path of government, family, school, and society has been proposed.

Style APA, Harvard, Vancouver, ISO itp.

25

Andri, Andri, Ng Poi Wong i Johnny Fransiscus. "Aplikasi Algoritma Semi �?¢â?¬â?? Fragile Image Watermarking Berdasarkan pada Region Segmentation". Jurnal SIFO Mikroskil 15, nr 1 (17.04.2014): 21–30. http://dx.doi.org/10.55601/jsm.v15i1.144.

Pełny tekst źródła

Streszczenie:

Kebanyakan algoritma semi-fragile watermarking yang telah ada memiliki kelemahan, seperti sifat tidak kelihatan (invisibility) yang jelek, robustness yang tidak sempurna pada beberapa rutin dari proses sinyal. Penyebab utamanya adalah karena kebanyakan algoritma menggunakan parameter kuantisasi tertentu tanpa mempertimbangkan perbedaan diantara citra. Untuk menyelesaikan permasalahan ini, Shengbing Che, Bin Ma, Jinkai Luo dan Shaojun Yu dari China (2009) [1] memperkenalkan sebuah algoritma image watermarking berdasarkan pada segmentasi region. Proses kerja dari sistem dimulai dari pemilihan citra sampul dan citra watermark hitam putih. Setelah itu, dilanjutkan pengisian nilai kunci dan proses pengacakan terhadap citra hitam putih. Kemudian, citra sampul akan dikonversi ke bentuk grayscale dan terakhir citra hitam putih akan ditempelkan ke dalam citra sampul. Citra watermark yang diperoleh dapat disimpan ke dalam sebuah file yang akan digunakan pada proses ekstraksi untuk mengekstrak keluar citra watermark hitam putih yang disisipkan di dalamnya. Hasil pengujian menunjukkan waktu eksekusi proses penempelan watermark relatif lebih cepat dari proses ekstraksi. Algoritma tidak bisa mengekstraksi citra hitam putih ketika citra watermark diberi efek brightness dan contrast. Citra hitam putih masih dapat terekstrak keluar walau citra watermark disisipkan noise atau dicrop. Apabila ada kesalahan pengisian kunci maka akan menyebabkan citra hitam putih menjadi tidak terekstrak keluar.

Style APA, Harvard, Vancouver, ISO itp.

26

Endale, Adugna, Girmay Medhin, Abdela Alte Hilo, Woldaregay Erku Abegaz i Mengistu Dadi Legesse. "Knowledge, Attitude, and Practice of Jinka University Students About Yellow Fever, Ethiopia: A Cross-Sectional Study". Risk Management and Healthcare Policy Volume 13 (sierpień 2020): 1225–36. http://dx.doi.org/10.2147/rmhp.s250930.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

27

Fesseha, Haben. "Assessment of community knowledge, attitude and practice on common zoonotic diseases in Jinka town, Southern Ethiopia". Gazette of Medical Sciences 1, nr 3 (30.07.2020): 18–29. http://dx.doi.org/10.46766/thegms.virology.20072206.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

28

Mesfin, Kebede, Shimbir Tesfaye, Kasa Girma, Abera Dejene i Girma Tsegaye. "Description, characterization and classification of the major soils in Jinka Agricultural Research Center, South Western Ethiopia". Journal of Soil Science and Environmental Management 8, nr 3 (17.03.2017): 61–69. http://dx.doi.org/10.5897/jssem2015.0498.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

29

Abdulkadir, Hanan, Meseret Girma, Zeleke Gebru, Negussie Boti Sidamo i Gebremaryam Temesgen. "Magnitude of Depression and Its Associated Factors Among Prisoners in Arba Minch and Jinka Town, Southern Ethiopia". Psychology Research and Behavior Management Volume 15 (czerwiec 2022): 1505–16. http://dx.doi.org/10.2147/prbm.s362303.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

30

Gemeda, D. O. "Climate Change Variability Analysis in and around Jinka, Southern Ethiopia. With Special Emphasis on Temperature and Rainfall". Journal of Agricultural Sciences – Sri Lanka 14, nr 3 (1.09.2019): 145. http://dx.doi.org/10.4038/jas.v14i3.8598.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

31

Berhe, Dargie Tsegay, i Derbew Belew. "Evaluation of Wild, Wine, Table, and Raisin Grapevine (Vitis spp.) Genotypes in Gedeo Zone, Southern Ethiopia". Scientific World Journal 2022 (29.01.2022): 1–15. http://dx.doi.org/10.1155/2022/6852704.

Pełny tekst źródła

Streszczenie:

Grapevine is one of the major horticultural crops of the world with the cultivated area exceeding 7.5 million ha used for a myriad of products ranging through fresh table grape, preserves, juice, wine, and raisins. The main objective of this study was to introduce twenty-eight grapevine cultivars (ten wild, ten wine, four table, and four raisin grapes) into Gedeo Zone for the first time and ampelographically characterize them in Dilla and Yirgacheffe agroecological conditions in Gedeo Zone, Southern Ethiopia, from August 2018 to July 2021. Ten Vitis abyssinica wild grapevine cultivars were collected from Adama, Addis Ababa, Alamata, Arba Minch, Bahir Dar, Dire Dawa, Gondar, Hawassa, Jimma, and Jinka areas. Additional ten world class wine grapes were gathered from Ziway Castel Winery, and four table and four raisin grapes were also collected from Raya Horti Farm and Koka Vineyard at the same time. The experiment was a 2 × 28 factorial arranged in randomized complete block design (RCBD) with three replications, and data were analyzed using the R-software. The analysis of variance revealed that the interaction of cultivar and location significantly ( P < 0.001 ) affected grapevine plant height, leaf number, number of fruits per plant, and tendril number per vine, while grapevine trunk diameter, flower cluster, root length, and number of suckers per vines were not significantly ( P > 0.05 ) influenced by the interaction of the two factors. Generally, the wine grapevine cultivars had lower canopy such as plant height, leaf number, number of tendrils, and suckering vines while these registered a higher number of fruits per plant, trunk diameter, flower cluster, and root length compared to the wild grapevine cultivars. The results of the present study suggested that Syrah, Chenin Blanc, and Grenache can produce high grapevine berry yield and wine quality in Gedeo Zone agroecology particularly in Dilla location. The wild grapevines collected from Dire Dawa, Arba Minch, Jinka, and Alamata were the potential candidates for the world class wine, raisin, and table grapevines which could open new frontiers in the future for Ethiopian native Vitis abyssinica wild grapevine breeding and genetic engineering that will help to move the national and international viticulture and enology industry forward. As the Ethiopian native grapevines are at the risk of total extinction, adequate conservation strategies are required. Breeding, detailed identification, and introducing the potential grapes in different regions of the country are needed. This finding represents a step forward in efforts to understand hybridization of Vitis abyssinica grapevine with Vitis vinifera and other new world Vitis species.

Style APA, Harvard, Vancouver, ISO itp.

32

Yoseph, Tekle, i Mhiretu Muluneh. "Performance evaluation of common bean [Phaseolus vulgaris (L.)] varieties for yield and yield components at Jinka, Southern Ethiopia". Journal of Agricultural Science and Practice 7, nr 1 (28.02.2022): 13–19. http://dx.doi.org/10.31248/jasp2021.318.

Pełny tekst źródła

Streszczenie:

A field experiment was conducted on the research field of Jinka Agricultural Center, South Omo Zone, Southern Ethiopia using eighteen improved common bean [Phaseolus vulgaris (L.)] varieties under rainfed conditions from 2019 to 2020 main cropping seasons. The objective of the study was to select the best performing common bean varieties in the target areas. The common bean varieties were eight red types, five speckle/mottled, and five white/creamy (SER125, DRK, DAB107, ROR1, KATB9, Remede, Hawassa Dume, Tatu, SAB632, Redwolyita, GLP2, Deme, Brazil2, KATB 1, Awash Metene, SAB736, Awash2, Wajo). The experiment was carried out using a randomized complete block design (RCBD) with three replications. The combined analysis of variance results showed that there were significant differences observed among the common varieties for all the studied traits. Based on the pooled mean over years, the seed yield ranged from 1338.867 kg ha-1 for the variety DAB107 to 3069.867 kg ha-1 for the variety SER125. The maximum seed yields of 3069.867 kg ha-1 for the variety SER125, 2845.600 kg ha-1 for the variety Deme, and 2825.267 kg ha-1 for the variety Tatu. The grain yield advantages of 45.46, 41.16, and 40.73% were obtained from the improved varieties SER125, Deme, and Tatu, respectively over the standard check variety namely Hawassa Dume. Therefore, the common bean varieties such as SER125, Tatu, and Deme could be recommended for the study area and other similar agro-ecologies, however, further research should be done to put the recommendation on a strong basis.

Style APA, Harvard, Vancouver, ISO itp.

33

Kassa, Shimelis, i Belayneh Muche. "Living on the Margin of Life: The Condition of Street Children During Covid-19 Outbreak in Three Selected Towns of SNNPR (Sodo, Jinka, and Arbaminch)". European Journal of Theoretical and Applied Sciences 1, nr 4 (6.07.2023): 55–70. http://dx.doi.org/10.59324/ejtas.2023.1(4).07.

Pełny tekst źródła

Streszczenie:

The objective of this study is to assess the socio-economic impacts of the COVID-19 crisis on street children, their awareness about COVID-19 transmission and support of government to street children in three selected towns of SNNPR (Jinka, Arbaminch, and Sodo). To achieve these objectives, concurrent mixed research designs were employed. To identify respondents, both convenience and purposive sampling techniques were used. Data were collected from both primary and secondary sources. As instruments of data collection; interview schedules, in-depth interviews, focus group discussions and key informant interviews were used. Finally, data were analyzed and interpreted using descriptive statistics and thematic analysis. The finding of the study depicted that the outbreak of COVID-19 worsen the social and economic problem of street children. Despite the social and economic impacts of COVID-19, no permanent support was given to the children both by the government and charity organizations. Moreover, the finding showed that street children suffer from various problems like lack of basic needs, depression and deprivation of work opportunity. Thus, holistic intervention should be used to address various problems that street children faced.

Style APA, Harvard, Vancouver, ISO itp.

34

Toquenaga, Yukihiko. "Jinkou-Seimei (Artificial Life: A Constructive Approach to the Origin/Evolution of Life, Society, and Language). Takaya Arita, Science Press, 2000 (In Japanese)". Artificial Life 7, nr 1 (styczeń 2001): 91–92. http://dx.doi.org/10.1162/106454601300328052.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

35

Erkihun, Ketema, Mamo Mesfin, Miskir Direslegn, Hussen Sultan i Boti Negussie. "Determinants of neonatal sepsis among neonates admitted in a neonatal intensive care unit at Jinka General Hospital, Southern Ethiopia". International Journal of Nursing and Midwifery 11, nr 3 (31.03.2019): 18–24. http://dx.doi.org/10.5897/ijnm2018.0335.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

36

Mishra, Shruti, Somanath Padhi, Rasheeda Mohamedali i Kishore Kumar. "Trephine Immuno-Histochemistry As an Useful Adjunct in Characterizing Myelonecrosis in Resource Poor Settings - a Study from India". Blood 134, Supplement_1 (13.11.2019): 5028. http://dx.doi.org/10.1182/blood-2019-128772.

Pełny tekst źródła

Streszczenie:

Introduction: Myelonecrosis is defined as necrosis of myeloid tissue within the hematopoietic medullary spaces with preservation of bony trabeculae. It is a rare finding on trephine which is reported to occur in 0.37% to 6.5% of all cases [1]. Most common cause of myelonecrosis is associated neoplasia [2]. Extensive myelonecrosis can make bone marrow aspiration and further evaluation difficult, leading to delay in diagnosis and management. We describe five such interesting cases with varying degree of myelonecrosis where immune-histochemistry in the necrosed zone helped us clinch the diagnosis. Cases and methods: Clinicopathological characteristics, bone marrow morphology and Immuno-histochemistry findings are tabulated below. In all the cases trephine biopsies were fixed with 10% neutral buffered formalin and decalcification was done with 14% EDTA for 48-72hrs (as per ICSH 2008 Guidelines). In all these cases, myelonecrosis was graded and ranged from mild to moderate. The procedure used was that of a semi-quantitative one. Grade I (mild): <20% of the biopsy Grade II (moderate-intermediate): 20-50% of the biopsy Grade III (severe-extensive): >50% of the biopsy. Gomori's technique was done for reticulin staining. Fibrosis was graded as per WHO protocols. Immuno-histochemistry was done by peroxidase - anti-peroxidase technique. Immuno-histochemical findings were recorded separately by two hemato-pathologists. Expression of each marker was graded as per strength and compared with the expression in the viable zones. The gradation of expression was done in a semi-quantitative manner. Mild expression: + Moderate expression: ++ Strong expression: +++ Discussion: Out of the five cases, three were hematological malignancies and rest two are metastatic solid tumors. Myelonecrosis in all the cases was of coagulative type. Myelonecrosis was extensive in 1/5 cases, moderate in 3/5 cases and patchy or focal in 1/5 cases. We found that the necrosed tumor cells retained their antigenicity for most of the markers. It was observed that even the intensity of expression was at par with that of the viable zones. The necrosed zone in case of B-cell precursor- acute lymphoblastic leukemia showed diffuse and strong positivity for CD10, CD79a, TdT and dim positive for CD34, thus confirming the diagnosis. Similarly, in the case of Non-Hodgkin's lymphoma the expression of markers in the necrosed areas showed strong antigenic expression for CD20, CD79a and nuclear positivity for Bcl 2, Bcl 6 and Mib 1. In the myeloma case retention of CD138, CD56 and Lambda light chain restriction was noted. Interestingly, both the cases with metastasis presented with bony pain and increased ALP (Alkaline Phosphatase). While in one case associated increase in PSA (Prostate specific antigen) in serum indicated the possibility of metastasis from a prostatic primary, the other case was evaluated in the line of myeloma. Immuno-histochemistry in the trephine suggested a possibility of metastasis from an occult primary. Later, on further evaluation a primary was found in the right breast of the patient. In both the metastatic cases, the expression of Cytokeratin was strong and diffuse. PSA was expressed in dot-like pattern. Jinkala et. al(3). in their study found that malignancy was the commonest cause of myelonecrosis. They found that neoplastic aetiology in 91% cases of marrow necrosis, out of which primary hematologic malignancy constituted 60% and rest was due to metastatic solid tumours. Also, most of the studies have proved that myelonecrosis itself is a bad prognostic factor in patients. Conclusion: Thus, we conclude Immuno-histochemistry is an useful adjunct to demonstrate the retained antigenicity in myelo-necrosed tissues; and could be useful in these cases as they are usually associated with scant and difficult aspirate. It can be done easily leading to a faster diagnosis of the patient even in resource poor settings too. This will save the patient from undergoing a painful bone marrow procedure again. References: 1. Markovic SN,. Pancytopenia due to bone marrow necrosis in acute myeloid leukemia: role of reactive CD8 cells. Am J Hematol 1998; 59:74. 2. Dunn Bone marrow necrosis in 38 adult cancer patients. J Famos Med Assoc 1993;92(12): 1107-10. 3. Jinkala S.R. Myelonecrosis: A Clinicopathological Study from a Tertiary Care Center in South India over a Twelve-Year Period. Bone Marrow Research 2014; 5 Figure Disclosures No relevant conflicts of interest to declare.

Style APA, Harvard, Vancouver, ISO itp.

37

Ababio, Kofi. "TOURISM AND INTER-CULTURAL UNDERSTANDINGS OF SUSTAINABILITY: Tourism in South Omo: Questions of Social Sustainability, Jinka, Ethiopia, 14?17 December 2005". Anthropology Today 22, nr 5 (październik 2006): 25–26. http://dx.doi.org/10.1111/j.1467-8322.2006.00465.x.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

38

Digesa, Lankamo Ena, Ararso Baru, Alemayehu Shanko, Mekidim Kassa, Zeleke Aschalew, Fikre Moga, Bereket Beyene i Tegegn Mulatu. "Incidence and Predictors of Pressure Ulcers among Adult Patients in Intensive Care Units at Arba Minch and Jinka Hospitals, Southern Ethiopia". BioMed Research International 2023 (15.04.2023): 1–8. http://dx.doi.org/10.1155/2023/9361075.

Pełny tekst źródła

Streszczenie:

Introduction. The incidence of a pressure ulcer in intensive care units (ICU) is significantly higher than in noncritical care settings. The patients in the ICU are the most vulnerable group to disruption of the skin’s integrity. Prior studies in Ethiopia failed to evaluate pressure ulcers in intensive care units and were limited to general wards. The purpose of this study was to identify the incidence and predictors of pressure ulcers in adult patients admitted to intensive care units in Southern Ethiopia. Methods. A single-arm prospective open cohort of 216 patients was used to determine the presence of a pressure ulcer in the intensive care units from June 2021 to April 2022. A consecutive sampling was used until the sample size was reached. The data were collected using a structured questionnaire and analyzed using Stata 14. A cumulative incidence of a pressure ulcer was computed. The life table was used to estimate the cumulative survival. A multivariable Cox proportional hazard regression was used to identify independent predictors of a pressure ulcer. An adjusted hazard ratio with a 95% CI was used to measure the degree of association; a P value ≤ 0.05 was considered significant. Results. Twenty-five patients developed a pressure ulcer (PU), making a cumulative incidence of 11.57%. Out of 25 incident cases of pressure ulcers, four-fifths (80%) of the study patients developed PU within 6 days of their admission to the ICUs. The incidence rate was 32.98 PU per 1000 person-days of ICU stay. Pressure ulcers were most commonly found on the sacrum, followed by the shoulder. Among the incident cases, 52% were stage 2 ulcers. The presence of friction or shearing forces, as well as being 40 years of age or older, was independently associated with pressure ulcers. Conclusion. The overall cumulative incidence of the pressure ulcer was lower than that in other studies but occurred at a faster rate. Age (40 years of age or older) and the presence of friction or shearing forces were the main predictors of pressure ulcers in the intensive care units. Therefore, nurses working in ICUs should continually anticipate the risk of a pressure ulcer. Moreover, special attention should be given to patients of advanced ages. Furthermore, monitoring the installation of a mattress, keeping bed linens unwrinkled, and keeping patients in a proper position on a bed to prevent or reduce friction or shearing forces are very crucial in the prevention of pressure ulcers.

Style APA, Harvard, Vancouver, ISO itp.

39

Sorrie, Muluken Bekele, Elias Amaje i Feleke Gebremeskel. "Pre-lacteal feeding practices and associated factors among mothers of children aged less than 12 months in Jinka Town, South Ethiopia, 2018/19". PLOS ONE 15, nr 10 (13.10.2020): e0240583. http://dx.doi.org/10.1371/journal.pone.0240583.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

40

Eshbel, Atlaw, Mihretu Muluneh i Mohamed Awol. "Evaluation of improved Cassava (Manihot esculanta Crantz) varieties in mid land area of South Omo Zone, Ethiopia". International Journal of Agricultural Research, Innovation and Technology 12, nr 1 (23.08.2022): 101–4. http://dx.doi.org/10.3329/ijarit.v12i1.61038.

Pełny tekst źródła

Streszczenie:

Cassava is one of the most important foods security crops, especially in those regions disposed to difficult crop environments. The crop is also grown in the southern part of Ethiopia and plays an important role for home consumption, animal feed and source of income for small-scale farmers. However, its productivity is still low due to the lack of improved planting materials. Therefore, the experiment was conducted at Jinka Agricultural Research Center’s research site during the 2018 and 2019 consecutive cropping seasons to investigate the adaptability of improved cassava varieties and to select high-yielding variety/varieties for the target area. Four improved cassava varieties (Hawassa-4, Kello, Qulle and Chichu) and one local check were used as treatments and arranged in randomized complete block design with three replications. ANOVA revealed that the interaction between year and variety showed non-significant, whereas varieties performed significantly different (p<0.05) for root yield and other yield-related characters considered in this study. The higher mean value of total root yield was recorded on Hawassa-4 (56.91 ton ha-1) followed by Kello (42.8 ton ha-1) and showed good mean performance for root yield-related parameters than local and Qulle varieties. In general, the varieties Hawassa-4 and Kello yielded better than local checks by 50.95% and 13.5%, respectively. Therefore, the variety Hawassa-4 followed by Kello was identified as the highest yielding and adaptable Cassava varieties at the midland area of South Omo Zone and similar agro-ecologies. Int. J. Agril. Res. Innov. Tech. 12(1): 101-104, June 2022

Style APA, Harvard, Vancouver, ISO itp.

41

KOBAYASHI, Yukiho, i Kazunobu TSUTSUI. "A Study on the Elements Required for Building Relationships with <i>Kankei Jinkou</i> (Non-Residents Who Are Not Family Members) in Rural Communities". JOURNAL OF RURAL PLANNING ASSOCIATION 39, nr 4 (30.03.2021): 394–404. http://dx.doi.org/10.2750/arp.39.394.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

42

Temtmie, Zebene, i Demssie Tefera. "The Role of Parenting Style in Instilling Adolescents Pro-social Behavior: The Case of Adolescent Students in Arba-minch, Konso, and Jinka, Southern Ethiopia". American Journal of Applied Psychology 9, nr 1 (2020): 22. http://dx.doi.org/10.11648/j.ajap.20200901.14.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

43

Saghafian, Bahram, i Shabnam Noroozpour. "Comment on “Development and testing of a new storm runoff routing approach based on time variant spatially distributed travel time method” by Jinkang Du, Hua Xie, Yujun Hu, Youpeng Xu, Chong-Yu Xu". Journal of Hydrology 381, nr 3-4 (luty 2010): 372–73. http://dx.doi.org/10.1016/j.jhydrol.2009.10.038.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

44

Fenta, Fkremariam, Derbie Alemu i Dagninet Alelign. "Magnitude of Drug-Resistant Gram-Positive Bacterial Pathogens, and Its Associated Factors from External Ocular Infected Patients Attending at Jinka General Hospital Ophthalmic Clinic, Southern Ethiopia". Infection and Drug Resistance Volume 15 (marzec 2022): 947–59. http://dx.doi.org/10.2147/idr.s356974.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

45

Godana, Wanzahun. "Prevalence of HIV⁄AIDS and its Associated Factors among Prevention of Mother-to-Child Transmission (PMTCT) Service Users in Jinka Town Health Institutions, South Omo Zone, South Ethiopia". Science Journal of Public Health 1, nr 3 (2013): 125. http://dx.doi.org/10.11648/j.sjph.20130103.13.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

46

Lee, Alice W., Valerie Poynor i JinKyu Choi. "Abstract A038: Racial disparities in health-related quality of life among cancer survivors in the United States". Cancer Epidemiology, Biomarkers & Prevention 32, nr 1_Supplement (1.01.2023): A038. http://dx.doi.org/10.1158/1538-7755.disp22-a038.

Pełny tekst źródła

Streszczenie:

Abstract Background: There were an estimated 16.9 million cancer survivors in the United States (U.S.) in 2019. Since this number is projected to increase to over 22 million by 2030 and cancer survivors often face long-term challenges and late effects of treatment, it has become increasingly important to evaluate patients’ health-related quality of life in order to better understand their needs, identify disparities, and develop strategies to improve their overall well-being. Racial/ethnic differences in cancer survivorship have been previously reported, but few have evaluated quality of life among a nationally representative, population-based sample of U.S. patients. Methods: We used self-reported data from the Medical Expenditure Panel Survey (MEPS) as well as its Experience with Cancer Survivorship Supplement questionnaire from 2016-17, which collected information on patient experiences with cancer including quality of life based on the Patient-Reported Outcomes Measurement Information System (PROMIS) measures of physical and mental health. A Global Physical Health (GPH) score using questions related to physical health, physical function, fatigue, and pain and a Global Mental Health (GMH) score using questions related to quality of life, mental health, social support, and emotional problems were calculated where the lower the score indicated the poorer the health. In addition, questions related to whether cancer had a positive impact on patients were considered as well. Multiple logistic regression models with odds ratios (ORs) and 95% confidence intervals (CIs) were used to examine the impact of race on these various quality of life/cancer experience outcomes after considering relevant confounders. Results: A total of 1608 cancer survivors (1225 non-Hispanic Whites, 165 Hispanic Whites, 176 Blacks, 42 Asians) were included. When compared to non-Hispanic Whites, only Blacks were statistically significantly more likely to have a low GPH score (OR=1.95, 95% CI 1.15-3.27) and a low GMH score (OR=1.89, 95% CI 1.24-2.89). However, Blacks and Hispanic Whites were statistically significantly more likely to report their cancer experience leading to positive things in their lives; for example, both racial groups were three times as likely to report that their cancer helped them cope better with life’s challenges relative to non-Hispanic Whites (OR=3.66, 95% CI 2.34-5.73 for Blacks, OR=2.91, 95% CI 1.68-5.03 for Hispanic Whites). Conclusions: There are important racial disparities when it comes to health-related quality of life among cancer survivors. Although Blacks were more likely to see the positive aspects of their cancer diagnosis, they still experienced poorer physical and mental health overall. Future studies should explore the factors that may be contributing to these racial disparities as they could greatly inform targeted strategies to improve the overall survivorship experience of cancer patients. Citation Format: Alice W. Lee, Valerie Poynor, JinKyu Choi. Racial disparities in health-related quality of life among cancer survivors in the United States [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr A038.

Style APA, Harvard, Vancouver, ISO itp.

47

Pradhan, Anjan K., Jinkal Modi, Santanu Maji, Amit Kumar, Praveen Bhoopathi, Padmanabhan Mannangatti, Chunqing Guo i in. "Abstract 3394: Simultaneous targeting of the PDZ1 and PDZ2 domains of MDA-9 inhibits melanoma metastasis". Cancer Research 83, nr 7_Supplement (4.04.2023): 3394. http://dx.doi.org/10.1158/1538-7445.am2023-3394.

Pełny tekst źródła

Streszczenie:

Abstract Metastasis poses significant obstacles to effective therapy and drug development. Melanoma differentiation-associated gene-9/Syntenin-1/Syndecan Binding Protein (MDA-9) is a pro-metastatic gene robustly and differentially expressed in cancer cells in comparison with corresponding adjacent normal/primary cells and represents an attractive therapeutic target to inhibit cancer cell dissemination and tumor growth. MDA-9 contains two tandem PDZ domains that provide a nexus for interactions with multiple proteins that can initiate the transcription of metastasis-associated genes. The goal of this project was to evaluate the efficiency of a unique first-in-class, second-generation MDA-9 dual-PDZ targeted pharmacological inhibitor generated using a combination of a PDZ1 small molecule and a PDZ2 selective peptide. Fragment-based drug discovery and NMR identified PDZ1i, an inhibitor of the PDZ1 domain, that effectively blocks cancer invasion in vitro and in vivo in multiple experimental animal models. To maximize the disruption of MDA-9 signaling an inhibitor has now been developed that simultaneously binds and blocks the activity of both PDZ domains. PDZ1i was joined to the second PDZ binding peptide (TNYYFV) with a PEG linker, resulting in IVMT-Rx-3 that simultaneously engages both PDZ domains of MDA-9. Mechanistic studies involved a combination of molecular and cell biology approaches and included both established and early passaged patient-derived melanoma cell lines. To test the efficacy of potential combinatorial effects in vivo we used a murine syngeneic model and B16F10, an immunotherapy-resistant murine cell line. After confirming synthesis using multiple analytical methods, e.g., HPLC, LC/MS, and NMR, the dissociation constant (determined by microscale thermophoresis (MST) analysis, of the IVMT-Rx-3 recombinant MDA-9 complex was 63 +/- 11 μM. This compound is not toxic to normal melanocytes or melanoma cells, but significantly inhibits invasion in vitro in a wide range of melanomas. IVMT-Rx-3 interrupts c-Src binding to MDA-9 and downregulates NF-kB activation. Inactivation of this transcription factor causes suppression of MMP2/MMP9 and inhibits the secretion of cytokines/growth factors. These molecular changes block cellular invasiveness and facilitate immune cytotoxicity by converting an unfavorable into a favorable tumor microenvironment culminating in the repression of melanoma metastasis. In addition, the in vivo anti-metastatic properties of IVMT-Rx-3 are enhanced when combined with an immune-checkpoint inhibitor. IVMT-Rx-3 is a unique MDA-9 antagonist in terms of composition that effectively inhibits melanoma metastasis as does our small molecule PDZ1i and holds potential for developing novel therapeutic strategies effectively targeting melanoma and in principle, a broad spectrum of human cancers that also overexpress MDA-9. Citation Format: Anjan K. Pradhan, Jinkal Modi, Santanu Maji, Amit Kumar, Praveen Bhoopathi, Padmanabhan Mannangatti, Chunqing Guo, Daniel K. Afosah, Mark Mochel, Nitai D. Mukhopadhyay, John M. Kirkwood, Xiang-Yang Wang, Umesh R. Desai, Devanand Sarkar, Luni Emdad, Swadesh K. Das, Paul B. Fisher. Simultaneous targeting of the PDZ1 and PDZ2 domains of MDA-9 inhibits melanoma metastasis [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 3394.

Style APA, Harvard, Vancouver, ISO itp.

48

Mehra, Siddharth, Supriya Srinivasan, Anna Bianchi, Austin Dosch, Samara Singh, Vanessa Garrido, Iago De Castro Silva i in. "Abstract B093: Alcoholic chronic inflammation driven CREB mediates acinar-to-ductal reprogramming and promote neoplastic progression". Cancer Research 84, nr 2_Supplement (16.01.2024): B093. http://dx.doi.org/10.1158/1538-7445.panca2023-b093.

Pełny tekst źródła

Streszczenie:

Abstract Introduction: Alcoholic chronic pancreatitis (ACP) is a progressive fibroinflammatory disease of the pancreas often characterized by extensive acinar cell injury leading to acinar-to-ductal metaplasia (ADM). However, the impact of ADM associated with ACP on the acceleration of oncogenic mutant Kras (Kras*)-driven tumorigenesis remains poorly understood. In this study, we aimed to unravel the underlying mechanism by which ACP-induced dysfunction and with Kras*, leads to the development of irreversible ADM and premalignant lesions that establish a tumor-permissive microenvironment for the emergence of high-grade pancreatic intraepithelial neoplasia (PanINs). Methods: ACP mice model was developed in acinar cell-specific Ptf1aCreERTM/+, Ptf1aCreERTM/+; LSL-KrasG12D/+ (KC), and genetic ablation of cyclic AMP response element-binding protein 1 (CREB) in KC (KCC−/−) mice crossed with or without R26R-EYFP reporter mice, and these mice were fed with alcohol-enriched or regular diet along with repetitive caerulein administration. Lineage tracing studies and acinar explants were employed to investigate the fate of adult acinar cells. ACP-induced mice were subsequently euthanized either 3 days or 21 days after ACP induction, the pancreas was collected for immunohistochemical analysis and examined for ADM, PanINs, fibrosis, and inflammation. To gain insights into the molecular mechanisms; kinase array analysis, acinar cell explant culture, Western blot and qPCR-based studies were conducted. Additionally, single-cell RNA sequencing (scRNA-seq) was employed to investigate cell-specific transcriptomic changes focusing on distinct cellular compartments. Results: Lineage tracing studies showed that ACP-induced ADM stems from direct transdifferentiating adult acinar cells to a ductal phenotype in Kras* mice. ACP induction with Kras* cooperatively provided a sustained Kras - dependent oncogenic program in inflammation-induced metaplastic progenitor cells. The upregulation of CREB accompanied this process of malignant transformation. CREB activation persists even after ACP withdrawal in KC mice compared to Ptf1aCreERTM/+ mice without mutant Kras. Acinar-specific CREB ablation attenuated advanced PanIN lesion development, impeding tumor progression in Kras* mice. Additionally, it reduced inflammation-induced tissue injury and facilitated acinar cell recovery. ScRNA-seq analysis revealed gene enrichment favoring acinar cell homeostasis and downregulation of ductal gene signatures in KCC−/− mice, further emphasizing CREB's pivotal role in modulating these cellular processes. Conclusion: Our findings demonstrate that Kras* sustains an irreversible ADM and PanIN through continuous activation of CREB. Additionally, we have identified that CREB mediates an oncogenic transcriptional program that drives tumor progression in the context of inflammation-induced disease. Importantly, our study reveals that ACP synergistically cooperates with Kras*-driven activated CREB, promoting the progression of ADM toward high-grade PanINs. Citation Format: Siddharth Mehra, Supriya Srinivasan, Anna Bianchi, Austin Dosch, Samara Singh, Vanessa Garrido, Iago De Castro Silva, Varunkumar Krishnamoorthy, Sudhakar Jinka, Jashodeep Datta, Nipun B. Merchant, Nagaraj Nagathihalli. Alcoholic chronic inflammation driven CREB mediates acinar-to-ductal reprogramming and promote neoplastic progression [abstract]. In: Proceedings of the AACR Special Conference in Cancer Research: Pancreatic Cancer; 2023 Sep 27-30; Boston, Massachusetts. Philadelphia (PA): AACR; Cancer Res 2024;84(2 Suppl):Abstract nr B093.

Style APA, Harvard, Vancouver, ISO itp.

49

Jaferi, Nishah, Siddharth Mehra, Varun Krishnamoorthy, Sudhakar Jinka, Anna Bianchi, Vanessa T. Garrido, Luis A. Nivelo, Ban Yuguang i Nagaraj S. Nagathihalli. "Abstract 1602: Leukemia inhibitory factor (LIF)-factor XIIIA mediated macrophage-stromal crosstalk in pancreatic cancer". Cancer Research 84, nr 6_Supplement (22.03.2024): 1602. http://dx.doi.org/10.1158/1538-7445.am2024-1602.

Pełny tekst źródła

Streszczenie:

Abstract Background: Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy marked by a highly immunosuppressive tumor microenvironment (TME). Macrophages are known to promote immunosuppression and exhibit a profibrotic transcriptional profile with potential involvement in extracellular matrix (ECM) remodeling. Previously, we identified hyperactivation of cancer cell intrinsic cyclic AMP response element binding protein 1 (CREB) regulates leukemia inhibitory factor (LIF) to mediate macrophage infiltration and polarization within the TME of PDAC. Subsequently, we observed that disrupting LIF-LIF receptor (LIFR) signaling therapeutically not only diminishes the infiltration of tumor-associated macrophages (TAMs) but also results in a decrease in ECM deposition. This study delves into the potential regulatory pathway through which LIF induces remodeling of the ECM within the PDAC TME. Methods: We targeted LIF-induced macrophage-stromal crosstalk using the LIFR antagonist (EC359) in an orthotopically tumor implanted LSL-KrasG12D/+; Trp53 R172H/+; Pdx1Cre/+ (KPC) mice model of PDAC. Sirius red staining in tumor sections was performed to assess ECM (collagen) deposition. Moreover, we performed RNA transcriptomics-based analysis of recombinant (rLIF) induced bone marrow derived macrophages harvested from syngeneic C57BL/6 mice. The Cancer Genome Atlas (TCGA) pancreatic cancer (PAAD) data set along with single-cell RNA sequencing (scRNA seq) were employed to assess the expression of major downstream targets of LIF. To validate the RNA-seq results, we conducted immunohistochemical analysis (IHC) on mouse PDAC tissue sections and quantitative polymerase (qPCR) analysis on RAW 264 macrophage cell line treated with rLIF or KPC CREBWT PDAC tumor cells conditioned media. Results: We observed a drastic decrease in both TAM infiltration and, of note, ECM deposition in orthotopically implanted KPC pancreas tumor mice tissue treated with EC359 as compared to vehicle. Mechanistically, our RNA-seq analysis unveiled a significant upregulation of Factor XIIIA (FXIIIa), a major downstream target of LIF. Notably, TCGA data revealed that FXIIIa mRNA expression is upregulated across PDAC tumors marked by poor survival outcomes. Moreover, scRNA seq and IHC established that TAMs highly express FXIIIa in the PDAC TME. In exploring the effect of LIF-LIFR signaling in the ECM, mouse RAW 264.7 macrophage lines incubated in high LIF conditions confirmed transcriptional upregulation of ECM-associated proteins such as FXIIIa as well as fibronectin. Conclusion: Our investigation provides valuable insights into the possible mechanism by which LIF triggers ECM remodeling, thereby contributing to the desmoplastic stroma. Significantly, our findings propose that LIF-regulated FXIIIa signaling in macrophages serves as a plausible mediator of the LIF-induced ECM remodeling in PDAC. Citation Format: Nishah Jaferi, Siddharth Mehra, Varun Krishnamoorthy, Sudhakar Jinka, Anna Bianchi, Vanessa T. Garrido, Luis A. Nivelo, Ban Yuguang, Nagaraj S. Nagathihalli. Leukemia inhibitory factor (LIF)-factor XIIIA mediated macrophage-stromal crosstalk in pancreatic cancer [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 1602.

Style APA, Harvard, Vancouver, ISO itp.

50

Jinka, Sudhakar, Siddharth Mehra, Varunkumar Krishnamoorthy, Anna Bianchi, Karthik Rajkumar, Andrew Adams, Haleh Amirian i in. "Abstract 4277: CREB-ROCK driven extracellular matrix remodeling exasperates pancreatic cancer progression". Cancer Research 84, nr 6_Supplement (22.03.2024): 4277. http://dx.doi.org/10.1158/1538-7445.am2024-4277.

Pełny tekst źródła

Streszczenie:

Abstract Background: Pancreatic Ductal Adenocarcinoma (PDAC) is characterized by a heightened oncogenic mutational burden, an immunosuppressive tumor microenvironment, and a dense desmoplastic stroma. During the tumor progression from in situ carcinoma to intraductal neoplasia, cancer cells manage to evade the stromal compartment and infiltrate into the ducts. This invasive tumor progression is often associated with the overexpression of extracellular matrix (ECM) modulating genes. Despite this correlation, there are currently no effective and specific inhibitors of ECM-altering pathways. By understanding the signaling mechanism, the ECM remodeling pathways may be intercepted to prevent invasive tumor progression. This study aims to elucidate the role of cAMP-response element binding protein 1 (CREB1) and its downstream effectors in regulating PDAC ECM remodeling. Methods: The Cancer Genome Atlas (TCGA) was quired for CREB1 expression and other ECM modulators in PDAC patients. In vitro, CRISPR/CAS9-based genomic editing was utilized to knockout CREB1 in the murine KPC cell line, on which RNA-seq analysis was performed. To investigate the effects of CREB in PDAC progression, a novel conditional CREB1 knockout (CREBfl/fl) was created in LSL-KrasG12D/+; Trp53 R172H/+; Pdx1Cre/+ (KPC) mice (KPCC-/-). Tumors were extracted and histologically evaluated. Immunoblotting and staining were conducted on both in vitro and in vivo samples. Chromatin immunoprecipitation sequencing (ChIP-seq) and qPCR were performed on the KPC CREBKO. Eukaryotic Promoter Database (EPD) and ENCODE databases were explored to evaluate the transcriptional role of CREB in regulating ECM genes. Results: Patient PDAC samples data from TCGA revealed elevated levels of CREB1, ROCK1, and ROCK2 compared to normal pancreatic tissues. When comparing high CREB expression to low CREB expression, upregulation of several ECM genes was noted, including ROCK1 and ROCK2 in patients with high CREB expression. In CREBKO, RNA-seq analysis revealed the downregulation of key ECM genes, including Mmp3, Mmp10, Lama3, and Fn1 compared to CREB wildtype. In our novel murine conditional knockout model, a substantial reduction in fibrosis was observed. In both in vitro and in vivo, immunoblot and staining demonstrated a marked reduction in the expression of ECM remodeling proteins upon CREB deletion. Through ChIP-seq, the direct involvement of CREB1 in the transcriptional regulation of Rock1 and Rock2 was established. EPD and ENCODE were utilized to confirm and validate our CREB regulation experimental findings. Conclusion: These findings demonstrate the role of CREB in PDAC progression, which may provide a potential target to intercept ECM remodeling via inhibition of the CREB-ROCK axis to suppress PDAC tumor progression and invasion. Citation Format: Sudhakar Jinka, Siddharth Mehra, Varunkumar Krishnamoorthy, Anna Bianchi, Karthik Rajkumar, Andrew Adams, Haleh Amirian, Samara Singh, Edmond W. Box, Erin Dickey, Nivelo L. Alberto, Ban Yuguang, Jashodeep Datta, Nipun Merchant, Nagaraj Nagathihalli. CREB-ROCK driven extracellular matrix remodeling exasperates pancreatic cancer progression [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 4277.

Style APA, Harvard, Vancouver, ISO itp.

Artykuły w czasopismach na temat „Jinkaku”

Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych