Artykuły w czasopismach na temat „Isaac T”
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Vishnoi, Vageesh. "Book review: T. M. Thomas Isaac and Michelle Williams, Building Alternatives: The Story of India’s Oldest Construction Workers’ Cooperative". Social Change 49, nr 2 (czerwiec 2019): 375–77. http://dx.doi.org/10.1177/0049085719844673.
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Kley, Elisabeth, Slater Bradley i Isaac Julien. "In Search of False Time: Slater Bradley/T. J. Wilcox/Isaac Julien". PAJ: A Journal of Performance and Art 23, nr 2 (maj 2001): 61. http://dx.doi.org/10.2307/3246510.
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Leonard, Bill J. "Book Review: Isaac T. Hecker: The Diary Romantic Religion in Anti-Bellum". Review & Expositor 87, nr 1 (luty 1990): 161. http://dx.doi.org/10.1177/003463739008700149.
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Hampton, Stephen. "Graham Beynon, Isaac Watts: Reason, Passion and the Revival of Religion (London: Bloomsbury T&T Clark, 2016), ppviii + 220." Scottish Journal of Theology 71, nr 2 (maj 2018): 249–51. http://dx.doi.org/10.1017/s0036930617000199.
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Entrialgo, Alberto Martín. "On the Road to Iberia : Sonata Form and Españolismo in "Asturies" from Espagne (Souvenirs) by Isaac Albéniz". Music Theory and Analysis (MTA) 9, nr 1 (15.05.2022): 56–70. http://dx.doi.org/10.11116/mta.9.1.3.
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This analytical vignette examines Isaac Albéniz's "Asturies" (T. 103B). Drawing on both Caplin's formal-functional and Vande Moortele's two-dimensional approaches, it argues that despite its apparent large-ternary form, "Asturies" uses an unequivocal sonata-form rhetoric combined with characteristic elements of Spanish folklore, a combination that became one of the most idiosyncratic features of Albéniz's musical language in his most famous work,Iberia . My analysis ultimately seeks to contribute to the appreciation of this forgotten composition and to acknowledge its importance in Albéniz's compositional development.
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Schmidtobreick, L., A. Bayo, Y. Momany, V. Ivanov, D. Barria, Y. Beletsky, H. M. J. Boffin i in. "On Our Multi-Wavelength Campaign of the 2011 Outburst of T Pyx". Proceedings of the International Astronomical Union 7, S285 (wrzesień 2011): 404–5. http://dx.doi.org/10.1017/s1743921312001226.
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AbstractThe well-known recurrent nova T Pyx has brightened by 7 magnitudes, starting on 2011 April 14, its first eruption since 1966. T Pyx is unique amongst recurrent novæ in being surrounded by a nebula formed of material ejected during previous eruptions. The latest eruption therefore offers the rare opportunity to observe a light echo sweeping through the existing shell, and a new one forming. The sudden exposure of the existing shell to high-energy light is expected to result in a change of the dust morphology as well as in the part destruction of molecules. We observe this process in the near- and mid-IR during several epochs using ESO's VLT instruments Sinfoni, Visir and Isaac. Unfortunately, in the data analysed so far we only have a tentative detection in Brα from the shell, so might in the end have to be content with upper limits for the emission from the various molecular bands and ionised lines.
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Situmorang, Irvan Rolyesh, i Yonson Pane. "Dampak Harga Dan Kualitas Rasa Terhadap Loyalitas Masyarakat Dalam Berbelanja Di Tau Kua Heci Medan". Journal of Society Bridge 2, nr 1 (10.01.2024): 12–22. http://dx.doi.org/10.59012/jsb.v2i1.36.
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Penelitian ini bertujuan Untuk mengetahui pengaruh Harga dan Cita Rasa terhadap Loyalitas Konsumen di Tau Kua Heci Medan. Metodologi penelitian yang digunakan adalah metode pendekatan kuantitatif, unit analisis dan observasi dalam penelitian ini adalah konsumen. Populasi dalam penelitian ini adalah seluruh konsumen Rumah Makan Tau Kua Heci dan Mie Rebus. Sampel yang akan digunakan dalam penelitian ini adalah sebanyak 272 konsumen berdasarkan tabel Isaac and Michael dengan metode sampel aksidental. Teknik pengumpulan data melalui kuesioner, observasi dan studi kepustakaan. Analisis ini mencakup validitas dan reliabilitas, uji asumsi klasik, analisis regresi berganda, pengujian hipotesis melalui uji t dan F, dan uji koefisien determinasi (R2). Hasil uji t menunjukkan bahwa harga berpengaruh signifikan terhadap loyalitas konsumen. Cita rasa berpengaruh signifikan terhadap loyalitas konsumen. Hasil uji F menunjukkan bahwa variable harga dan cita rasa secara simultan berpengaruh signifikan terhadap loyalitas konsumen
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Neuhäuser, Ralph, Nuria Huélamo, Eike W. Guenther, Wolfgang Brandner, João Alves, Fernando Comerón, Monika G. Petr i Jean-Gabriel Cuby. "Ground-based exoplanet near-infrared search by imaging and spectroscopy: 3 new companion candidates in TWA". Symposium - International Astronomical Union 202 (2004): 465–67. http://dx.doi.org/10.1017/s0074180900218512.
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We report first results from our ground-based infrared imaging search for sub-stellar companions (brown dwarfs and giant planets) of young (up to 100 Myrs) nearby (up to 100 pc) stars, where companions should be well separated from the central stars and still relatively bright due to ongoing accretion and/or contraction. Our observations are performed mainly with SOFI and SHARP at the ESO 3.5m NTT on La Silla (imaging) and with ISAAC at the ESO 8.2m Antu (VLT-UT1) on Cerro Paranal (imaging and spectroscopy), all in the H- and K-bands. Here, we present new companion candidates1 around three T Tauri stars (TWA-8 A, RXJ1121.1-3845, and RXJ1121.3-3447 N) in the TW Hya group, which would have been sub-stellar if at the same distance and age as the T Tauri stars, but are found to be background stars by spectroscopy.
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Universitas Esa Unggul, Ferryal Abadi. "JUMPA Vol. 5 No. 3 Oktober 2018 Keselamatan Kerja, Kesehatan Kerja Dan Kepemimpinan : Dampaknya Terhadap Produktivitas Kerja". Jurnal Manajemen dan Perbankan (JUMPA) 5, nr 3 (31.10.2018): 20–28. http://dx.doi.org/10.55963/jumpa.v5i3.264.
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Penelitian ini bertujuan untuk menguji apakah ada pengaruh Keselamatan kerja, Kesehatan Kerja dan Kepemimpinan terhadap Produktivitas Kerja Pegawai PPSU di Kecamatan Tebet Jakarta Selatan. Penelitian ini menggunakan data primer. Populasi terjangkau dalam penelitian ini berjumlah 150 karyawan. Berdasarkan tabel Isaac dan Michael, jumlah sampel dalam penelitian ini adalah 62 responden. Teknik pemilihan responden menggunakan proporsional random sampling, dengan menggunakan metode proporsional random. Data penelitian diperoleh dari hasil penyebaran kuesioner kemudian dilakukan pengolahan data penelitian dengan melakukan pengujian regresi linier berganda untuk mengetahui hasil hubungan variabel-variabel yang diteliti menggunakan aplikasi SPSS 25. Hasil penelitian ini menunjukkan bahwa variabel keselamatan kerja memiliki nilai sig 0,038 < dari 0,05 dan memiliki t hitung 2,112 > dari t tabel 1,986, disimpulkan bahwa keselamatan kerja secara parsial berpengaruh signifikan terhadap produktivitas kerja. Kesehatan Kerja memiliki nilai sig 0,000 < dari 0,05 dan memiliki t hitung 4,554 > dari t tabel 1,986, secara parsial berpengaruh signifikan terhadap produktivitas kerja. Kepemimpinan memiliki nilai sig 0,008 < 0,05 dan memiliki t hitung 2,773> dari t tabel 1,986. Maka dapat disimpulkan di parsia. Keselamatan Kerja, Kesehatan Kerja dan Kepemimpinan terhadap Produktivitas Kerja memiliki nilai sig 0,000 < 0,05 dan nilai F hitung sebesar 35,768> dari F tabel sebesar 2,706. Sehingga dapat disimpulkan bahwa terdapat pengaruh yang signifikan antara Keselamatan Kerja, Kesehatan Kerja, dan Kepemimpinan secara simultan terhadap Produktivitas Kerja, dan R2 sebesar 53,1%
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Simanjuntak, Jontro. "PENGARUH IKLAN, KUALITAS LAYANAN DAN KEPERCAYAAN MEREK TERHADAP MINAT BELI PADA TOKO ONLINE LAZADA". E-Bisnis : Jurnal Ilmiah Ekonomi dan Bisnis 13, nr 1 (25.06.2020): 1–12. http://dx.doi.org/10.51903/e-bisnis.v13i1.143.
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Marketing is very important in understanding consumers and markets by forming products that are in accordance with the wishes of consumers and the market in order to achieve the expected image. In the marketing world it is inseparable from advertising that can help in promoting products in a marketing, as well as the level of service quality that is able to maintain and brand trust of consumers who have a close relationship to marketing. In this study aims to determine how the influence of Advertising, Service Quality and Brand Trust On Purchase Interest in Lazada Online Stores. The sample is determined using the Isaac and Michael formula with a sample of 270 respondents, and the sampling technique uses purposive sampling, then testing the hypothesis with the support of SPSS application version 22. The advertising variable has a significance value of 0,000 <0.05 alpha and a t value of 12,951> 1,969 values t table. The service quality variable has a significance value of 0,048 <0.05 alpha and t count value is 1.984> 1.969 t table value. The variable of brand trust has a significance value of 0,033 <0.05 alpha and t count value of 2.140>1.969 t table value. Simultaneous advertisement, service quality and brand trust are f table equal to 147,136> 2,64 table f value, and sig <alpha with 0,000> 0,05.
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Haridas, Rajesh P. "“Gentlemen! This Is No Humbug”". Anesthesiology 124, nr 3 (1.03.2016): 553–60. http://dx.doi.org/10.1097/aln.0000000000000944.
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Abstract The proclamation, “Gentlemen! this is no humbug,” attributed to John Collins Warren, M.D., was not identified in any contemporaneous eyewitness report of William T. G. Morton’s October 16, 1846, demonstration of ether at Massachusetts General Hospital. The earliest known documentation of the proclamation is in Nathan P. Rice’s biography of Morton, first published in 1859. Only three eyewitnesses, Washington Ayer, M.D., Robert Thompson Davis, M.D., and Isaac Francis Galloupe, M.D., reported Warren’s alleged proclamation. However, their accounts first appeared in 1896, 50 yr after Morton’s demonstration of etherization. Although Warren’s alleged proclamation appears plausible, the overall impression from eyewitness statements and publications relating to the October 16, 1846, demonstration of etherization is that it may not have been made.
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Qudsiyah, Ummi. "Relationship of Internal Locus Of Control To Career Maturity Through Self-Efficacy". Suluh: Jurnal Bimbingan dan Konseling 9, nr 1 (26.09.2023): 43–52. http://dx.doi.org/10.33084/suluh.v9i1.6546.
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This research aims to determine the relationship between internal locus of control and career maturity through student self-efficacy. The sample used was active students at Semarang State University 2017. The sampling technique in this research used a random sampling technique with degrees of error using the Isaac Michael table guide. The data analysis technique used is the template/model 4 mediation statistical analysis technique developed by Hayes. The research results show that internal locus of control through self-efficacy does not significantly affect the career maturity of students at the Faculty of Education, Semarang State University. The internal locus of the control variable, which has no significant effect on self-efficacy, can be explained by (β = 0.0937; t(321) = 0.5160; and p > 0.05).
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Hasana, Uldri Helta, i Gali Eksa Pratama. "Hubungan Efikasi Diri dan Deprivasi Relatif Terhadap Kinerja Guru di SMKN 2 Kota Sungai Penuh". Leader: Jurnal Manajemen Pendidikan Islam 2, nr 1 (26.05.2024): 163–75. http://dx.doi.org/10.32939/ljmpi.v2i1.3693.
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Penelitian ini berawal dari kenyataan di sekolah yaitu kinerja guru yang belum maksimal, hal tersebut dipengaruhi oleh tingkat kesadaran, dan tugas pokok sebagai seorang guru. Di antara cara menghasilkan kinerja guru yang baik adalah dengan seorang guru harus memiliki Efikasi Diri dan Deprivasi Relatif yang baik supaya sekolah tersebut mendapatkan hasil yang maksimal. Adapun tujuan dari penelitian ini yaitu untuk mengetahui: (1) hubungan efikasi diri terhadap kinerja guru, (2) hubungan deprivasi relatif terhadap kinerja guru, (3) hubungan efikasi diri dan deprivasi relatif terhadap kinerja guru. Pendekatan yang dipakai dalam penelitian ini adalah kuantitatif yang berjenis asosiatif kausal. Teknik pengumpulan data yang digunakan yaitu kuesioner yang disebarkan langsung ke sekolah tersebut, dan menggunakan SPSS 2022 untuk mencari hasil. Sampel dalam penelitian ini berjumlah 78 responden dengan teknik pengambilan sampel adalah melalui tabel Isaac dan Michael. Hasil penelitan membuktikan bahwa varibel Efikasi Diri (X1) tidak berpengaruh positif dan signifikan terhadap variabel kinerja guru (Y) dengan nilai T hitung 0,499 < T tabel 1,991, variabel Deprivasi Relatif berhubungan positif dan signifikan terhadap variabel kinerja guru (Y) dengan nilai T hitung 2,267 > T tabel 1,991, variabel Efikasi Diri dan Deprivasi Relatif berhubungan dan signifikan secara simultan terhadap kinerja guru dengan nilai signifikan 0,000 > 0,05.
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Alberto, Rodrigo Batista, Alessandro Bartz i Marcio Cappelli Alo Lopes. "Por uma nova abordagem de leitura bíblica: uma contraproposta à hermenêutica fundamentalista a partir da teologia de A. T. Queiruga". Protestantismo em Revista 43, nr 2 (23.01.2018): 179. http://dx.doi.org/10.22351/nepp.v43i2.3035.
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Por uma nova abordagem de leitura bíblica: Uma contraproposta à hermenêutica fundamentalista a partir da teologia de A. T. Queiruga ocupa-se com a necessidade apresentada pelos tempos pós-modernos no que tange à revisão da hermenêutica adotada pelas igrejas protestantes. Este artigo faz uso do método baseado na pesquisa bibliográfica e visa apontar um caminho que ajude a superar o modelo fundamentalista. A reflexão orbita sobre uma questão básica para o artigo: pode-se ressignificar a compreensão literal dos textos bíblicos sem se desviar dos princípios do Reino Deus anunciados por Jesus? Ou seja, o foco do trabalho está em verificar se a riqueza do texto perpassa sua recepção literal e, apesar de introduzir um certo incômodo ao entendimento comum, isso não desonraria sua mensagem. Para tal, pretende-se contrapor os pontos substanciais do movimento fundamentalista com a abordagem do teólogo Queiruga, sobretudo no primeiro capítulo do livro Do terror de Isaac ao Abbá de Jesus.
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Nathaya, Azzahra Dynaeira, Nurdin Hidayat i Sholatia Dalimunthe. "The Effect of Emotional Intelligence with Work-Life Balance and Burnout on Job Satisfaction". Journal of Business and Behavioural Entrepreneurship 6, nr 1 (11.10.2022): 21–35. http://dx.doi.org/10.21009/jobbe.006.1.04.
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This study aims to find the effect of Emotional Intelligence with Work-Life Balance and Burnout on Job Satisfaction. The method used is a quantitative method. The sampling technique used purposive sampling which refers to Isaac and Michael's table so that a population of 248 respondents was obtained. The object of research in this study is a teacher at a State Vocational School in DKI Jakarta. Data were collected through a questionnaire using a modified 4-point Likert scale. The results showed that emotional intelligence had a positive effect on job satisfaction, with a t-statistic value > 1.96, which was 8.795. Work-life balance has a positive effect on job satisfaction, with a t-statistic value > 1.96, which is 3,533. Burnout has a negative effect on job satisfaction, with a t-statistical value > 1.96, which is 4.610. Emotional intelligence has a positive effect on work-life balance, with a t-statistic value > 1.96, which is 7.263. Emotional intelligence has a negative effect on Burnout, with a t-statistic value <1.96 which is 7358. Work-life balance mediates the effect of emotional intelligence on job satisfaction, with a t-statistic value > 1.96, which is 4,021. Burnout mediates the effect of emotional intelligence on job satisfaction, with a t-statistic value > 1.96, which is 2.859. There is an influence of 54.7% between the dependent variable, namely emotional intelligence (X), work-life balance (Z1) and Burnout (Z2) on the dependent variable in the form of Job Satisfaction (Y).
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Adi Jaya, Umban, Intan Rieke Febriyanti i Toni Maryanto. "Pengaruh training dan skill terhadap performance Pekerja Migran Indonesia (PMI) di luar negeri pada kantor Badan Pelindungan Pekerja Migran Indonesia (BP2MI) Bekasi". Fair Value: Jurnal Ilmiah Akuntansi dan Keuangan 5, nr 5 (28.12.2022): 2065–71. http://dx.doi.org/10.32670/fairvalue.v5i5.2701.
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Humans often experience change and growth, which can lead to all kinds of challenges that need to be faced and overcome properly. The achievement of company goals can be realized if the company's human resources show good work performance. The purpose of this study was to see how different dimensions or variables, such as training and skills, affected the performance of Indonesian migrant workers abroad. The research method used was a survey method using a questionnaire distributed to 89 people using the Isaac and Michael table equations. While the instrument quality testing techniques include validity and reliability tests, and data analysis techniques such as descriptive analysis and correlation, as well as hypothesis testing using multiple linear regression analysis. The results of this study indicate that two independent variables have a significant effect on performance, namely the training variable with a t-value of 0.933 > 1.98 t-table and a significance value of 0.353 > 0.05 and skills with a t-count of 3.397 > 1.97 t-table and a significant value of 0.001 0.05. Research limitations and implications: This analysis was only carried out in one BP2MI office, and only two dimensions or variables were tested. It is hoped that the implementation of training and skills can be formulated and adapted to the needs of Indonesian migrant workers at BP2MI so that it can be implemented.
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Diyah Lestari, Herwiek, i Ady Achadi. "Instrument Readiness Sebagai Faktor Yang Berpengaruh Terhadap Intensi Berwirausaha Mahasiswa". Majalah Imiah Manajemen dan Bisnis 19, nr 1 (30.05.2022): 35–46. http://dx.doi.org/10.55303/mimb.v19i1.135.
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Penelitian ini bertujuan untuk menganalisis pengaruh intrumen readiness terhadap intensi berwirausaha mahasiswa. Penelitian ini dilakukan pada mahasiswa Program Studi Manajemen Fakultas Ekonomika dan Bisnis Universitas Wijayakusuma Purwokerto. Adapun jumlah sampel yang digunakan sebanyak 65 responden, dan teknik pengambilan sampelnya dengan menggunakan metode simple random sampling. Untuk menentukan ukuran sampel menggunakan metode yang dikembangkan oleh Isaac dan Michael. Alat analisis yang digunakan Regresi Linear Berganda (Multiple Regression).
Hasil analisis dengan regresi liner berganda diperoleh nilai koefisien dari variabel Capital Through (b1= 0,284), Ketersediaan Information (b2= 0,642), dan Networking (b3= 0,371) dan dengan menggunakan level of Confidence 95% (α=0,05) dan degree of freedom (df)= (n-k) = (65-4)= 61 maka diperoleh t tabel sebesar 1,999. Sedangkan t hitung untuk masing-masing variabel independen adalah Capital Through (th1=3,251), Ketersediaan Information (th2= 7,672), dan Networking (th3= 6,715). Karena th1, th2, th3 > t tabel, maka Ho ditolak. Hal ini dapat artikan bahwa Capital Through, Ketersediaan Information, dan Networking berpengaruh positif dan signifikan terhadap Entrepreneurial Intention Mahasiswa Fakultas Ekonomika dan Bisnis Unwiku. Hal ini menunjukkan bahwa semakin baiknya Dimensi Instrument Readiness yang terdiri dari Capital Through, Ketersediaan Information, dan Networking yang dimiliki, maka semakin meningkatkan intensi mahasiswa Fakultas Ekonomika dan Bisnis untuk berwirausaha
Kata kunci: Akses Modal, Informasi, Jaringan Sosial, dan Intensi Berwirausaha
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Charalampous, Charis. "Isaac Watts: Reason, Passion, and the Revival of Religion, GrahamBeynon, Bloomsbury T&T Clark, 2016 (ISBN 978-0-5676-7013-7), viii + 220 pp., hb £95". Reviews in Religion & Theology 25, nr 4 (październik 2018): 632–34. http://dx.doi.org/10.1111/rirt.13361.
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Lestari, Yenni, Endang Kusdiah Ningsih i Saskia Jamilah Khairany. "PENGARUH PENGHARGAAN FINANSIAL DAN TIPE KEPRIBADIAN TERHADAP MINAT MAHASISWA AKUNTANSI MENJADI AKUNTAN PUBLIK PADA PERGURUAN TINGGI SWASTA DI PALEMBANG". Surplus: Jurnal Riset Mahasiswa Ekonomi, Manajemen, dan Akuntansi 2, nr 1 (2.07.2022): 46–55. http://dx.doi.org/10.35449/surplus.v2i1.504.
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Tujuan penelitian ini adalah untuk mengetahui pengaruh penghargaan finansial dan tipe kepribadian yang mempengaruhi minat mahasiswa akuntansi menjadi akuntan publik pada perguruan tinngi swasta di kota Palembang. Data diambil dengan cara menyebarkan kuesioner secara online kepada 8 Universitas Swasta di Kota Palembang. Pemilihan sampel dengan menggunakan quota sampling menggunakan tabel isaac dan michael. Jumlah sampel yang digunakan adalah 251 responden. Penelitian ini menggunakan SPSS versi 25 untuk menganalisis data. Metode analisis yang digunakan adalah regresi linier berganda dan metode deskriptif komparatif. Hasil penelitian ini adalah secara parsial hanya penghargaan finansial saja yang mempunyai pengaruh signifikan terhadap minat mahasiswa akuntansi menjadi akuntan publik, sementara faktor tipe kepribadian tidak berpengaruh signifikan. Variabel dalam penelitian ini terdiri dari Penghargaan Finansial (X1), Tipe Kepribadian (X2). Berdasarkan hasil uji t, menunjukkan signifikansi penghargaan finansial 0.000 < 0.05 , tipe kepribadian 0.384 > 0.05. Hasil dari penelitian ini adalah penghargaan finansial berpengaruh terhadap minat mahasiswa akuntansi menjadi akuntan publik, sedangkan tipe kepribadian tidak berpengaruh terhadap minat mahasiswa menjadi akuntan publik.
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Permata, Adisetia, Sri Zulaihati i Achmad Fauzi. "PERSEPSI GURU TENTANG SUPERVISI KEPALA SEKOLAH, MOTIVASI KERJA DAN KINERJA GURU: STUDI DI SMK NEGERI 26 JAKARTA". Jurnal Pendidikan Ekonomi dan Bisnis (JPEB) 4, nr 2 (20.05.2017): 65. http://dx.doi.org/10.21009/jpeb.004.2.4.
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This study aims to determine the relationship between the perception of the Supervision Principal and Work Motivation on Teacher Performace in SMK Negeri 26 Jakarta. The sampling technique was conducted by random samplimg. The attainable population in this research were all teacher in status PNS is 67 teachers. The sample used by the tabel Isaac and Michael is 58 teachers. The simple linier regression and resulted Ŷ = 0,048X1 + 0,074X2 + 69,062. Relationship between the teacher perception of supervision principal with teacher performance, and work motivation with teacher performance are significantly positive. In simultan, relationhip between teacher perception of supervision principal, work motivation with teacher performance are significantly positively correlated. Normality test result were calculate with SPSS shows that all the variables above 0,05, inicated normally distributed. In partial test, significance t hitung teacher perception of supervision principal and work motivation size is 5,405 with significance 0,000 so, it indicated possitive significantly related between them.
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Sukemi, Ganda Yulida, i Zuraidah. "Effect Of Consumer Knowledge On Decisions To Invest Share In The Investment Gallery Of The Indonesia Stock Exchange UNISKA Kediri". Maro: Jurnal Ekonomi Syariah dan Bisnis 6, nr 2 (13.11.2023): 356–68. http://dx.doi.org/10.31949/maro.v6i2.3462.
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Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh pengetahuan konsumen terhadap keputusan berinvestasi saham di Galeri Investasi Bursa Efek Indonesia UNISKA Kediri. Peneliti dalam penelitian ini menggunakan pendekatan kuantitatif. Jenis penelitian yang digunakan adalah asosiatif atau hubungan, dengan bentuk hubungan kausalitas. Teknik pengambilan sampel adalah menggunakan teknik simple random sampling. Dengan bantuan tabel dari Isaac dan Michael pada tingkat kesalahan 5% dan populasi sebesar 150 maka diperoleh sampel penelitian sebanyak 105 investor. Berdasarkan hasil penelitian yang dilakukan dapat ketahui bahwa pengetahuan konsumen mengenai Galeri Investasi Bursa Efek Indonesia UNISKA Kediri termasuk kategori sangat mengetahui. Sedangkan keputusan berinvestasi saham di Galeri Investasi Bursa Efek Indonesia UNISKA Kediri termasuk kategori sangat setuju. Uji t memiliki nilai thitung (14,633) ≥ ttabel (1,98326), maka berarti H0 ditolak dan H1 diterima. Hal ini menunjukkan bahwa ada pengaruh yang signifikan antara variabel pengetahuan konsumen terhadap variabel keputusan berinvestasi. Serta nilai R square sebesar 0,675 menunjukkan besarnya pengaruh variabel pengetahuan konsumen terhadap variabel keputusan berinvestasi yaitu sebesar 67,5%.
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Bailhache, Patrice. "Isaac Beeckman a-t-il démontré la loi des cordes vibrantes selon laquelle la fréquence est inversement proportionnelle à la longueur ?" Revue d'histoire des sciences 45, nr 2 (1992): 337–44. http://dx.doi.org/10.3406/rhs.1992.4634.
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Garber, Zev. "Bridging between Sister Religions: Studies of Jewish and Christian Scriptures Offered in Honor of Prof. John T. Townsend by Isaac Kalimi". Catholic Biblical Quarterly 81, nr 3 (2019): 571–74. http://dx.doi.org/10.1353/cbq.2019.0177.
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Indratno, Indratno. "Pengaruh Kebiasaan Belajar Daring terhadap Hasil Belajar Kognitif Siswa pada Mata Pelajaran Bahasa Indonesia Kelas XII IPA di SMA N Kerinci". Jurnal Ilmiah Dikdaya 11, nr 2 (29.09.2021): 215. http://dx.doi.org/10.33087/dikdaya.v11i2.217.
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Tujuan penelitian ini adalah untuk mengetahui pengaruh kebiasaan belajar daring dengan hasil belajar kognitif siswa pada mata pelajaran bahasa Indonesia kelas XII IPA di SMA Negeri 7 Kerinci. Penelitian ini ini menggunakan metode penelitian kuantitatif dengan pendekatan asosiatif. . Populasi dalam penelitian ini sebanyak 97 siswa dan diambil beberapa sampel melalui teknik pengambilan sampel dengan menggunakan simple random sampling, dimana pengambilan sampel tiap kelas ditentukan seimbang atau sebanding dengan banyaknya subjek dari setiap kelas. Untuk menghitung sampel penelitian dari populasi tersebut, peneliti menggunakan pedoman penentuan sampel yang dikembangkan dari Isaac dan Michael dengan taraf tingkat kesalahan 5% sehingga sampel dalam penelitian ini sebanyak 32 siswa. Instrumen angket kebiasaan belajar daring (X) penelitian ini menggunakan skala likert untuk mengukurnya, dan hasil belajar kognitif beardasarkan hasil belajar ujian berupa pengetahuan pembelajaran pada pembelajaran bahasa Indonesia. Selanjutnya dilakukan uji validitas dan reliabilitas dari angket tersebut untuk mengumpulkan data. Setelah data terkumpul dilakukan uji analisis deskriptif, uji normalitas, uji homogenitas, uji hipotesis dengan menggunakan uji regresi sederhana dan uji t. Hasil penelitian ini bahwa terdapat pengaruh kebiasaan belajar daring terhadap hasil belajar kognitif siswa kelas XII IPA SMA Negeri 7 Kerinci ditandai dengan nilai t hitung > t tabel dan siginifikansi 0,040 < 0,05. Besarnya pengaruh kebiasaan belajar daring terhadap hasil belajar bahasa Indonesia siswa kelas XII IPA SMA Negeri 7 Kerinci tergolong kuat yaitu sejumlah 51% dengan sisa 49% dipengaruhi oleh faktor lain di luar penelitian.
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Noll, Thomas. "Consistent Pitch Height Forms: A commentary on Daniel Muzzulini's contribution Isaac Newton's Microtonal Approach to Just Intonation". Empirical Musicology Review 15, nr 3-4 (28.06.2021): 268–72. http://dx.doi.org/10.18061/emr.v15i3-4.8243.
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This text revisits selected aspects of Muzzulini's article and reformulates them on the basis of a three-dimensional interval space E and its dual E*. The pitch height of just intonation is conceived as an element h of the dual space. From octave-fifth-third coordinates it becomes transformed into chromatic coordinates. The dual chromatic basis is spanned by the duals a* of a minor second a and the duals b* and c* of two kinds of augmented primes b and c. Then for every natural number n a modified pitch height form hn is derived from h by augmenting its coordinates with the factor n, followed by rounding to nearest integers. Of particular interest are the octave-consitent forms hn mapping the octave to the value n. The three forms hn for n = 612, 118, 53 (yielding smallest deviations from the respective values of n h) form the Muzzulini basis of E*. The respective transformation matrix T* between the coordinate representations of linear forms in the Muzzulini basis and the dual chromatic basis is unimodular and a Pisot matrix with the dominant eigen-co-vector very close to h. Certain selections of the linear forms hn are displayed in Muzzuli coordinates as ball-like point clouds within a suitable cuboid containing the origin. As an open problem remains the estimation of the musical relevance of Newton's chromatic mode, and chromatic modes in general. As a possible direction of further investigation it is proposed to study the exo-mode of Newton's chromatic mode
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Selatang, Fabianus. "ASRAMA DAN PRESTASI AKADEMIK". SAPA - Jurnal Kateketik dan Pastoral 4, nr 1 (31.05.2019): 71–85. http://dx.doi.org/10.53544/sapa.v4i1.70.
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Mahasiswi Program Studi Pelayanan Pastoral STP-IPI Malang bermukim di asrama; dalam satu lingkungan yang nyaman dan terlindung. Keadaan tersebut mendorong tim peneliti untuk melakukan penelitian atas situasi mereka sebagai warga asrama dan sebagai mahasiswa. Penelitian ini bertujuan mendeskripsikan pengaruh hidup berasrama terhadap prestasi akademik mahasiswa. Metode yang dipakai ialah metode kuesioner. Instrumen yang dipakai terkait metode kuisioner ini ialah angket dengan skala bertingkat. Variabel bebasnya ada lima antara lain lokasi (X1), pelayanan (X2), kapasitas (X3), dan pengelolaan (X4), sedangkan variabel terikatnya ialah prestasi akademik (Y). Sampel yang dipakai ialah simple random sampling. Jenis penelitiannya ialah penelitian kuantitatif. Desain penelitiannya ialah studi korelasional. Jumlah populasinya 45 orang, sedangkan sampelnya berjumlah 42 orang. Penentuan sampel menggunakan Rumus Isaac dan Michael dengan tingkat kesalahan 0,05%. Analisa data yang dipakai ialah mengukur korelasi antar variabel dengan menggunakan metode korelasi multi variant dan analisa regresi linier berganda. Hasil pengujian hipotesa dengan uji T antara lain nilai Sig. X1 sebesar 0,946 nilai T hitung -0,068, X2 sebesar 0,311 dan nilai T hitung 0,1028, X3 sebesar 0,070 nilai T hitung 1,867, dan X4 sebesar 0,074 dan nilai T hitung 1.841. Pengujian hipotesa dengan uji F untuk melihat pengaruh secara simultan variabel bebas terhadap variabel terikatnya, diperoleh hasil nilai signifikansinya adalah 0,196 dan nilai F hitung 1,608. Sedangkan, berdasarkan analisa korelasi multi variant diperoleh data: X1= 0,013, X2=13,2; X3= 13,2; dan X4=14,8. Kesimpulannya H1 dan H2 ditolak yang berarti tidak terdapat pengaruh X1 dan X2 terhadap Y, sedangkan H3 dan H4 diterima yang berarti terdapat pengaruh X3 dan X4 terhadap Y. Sedangkan, pengujian hipotesa dengan uji F tidak terdapat pengaruh secara simultan pengaruh variabel bebas terhadap variabel terikat. Berdasarkan hasil analisa korelasi multi variant dan tabel nilai interpretasi nilai r, disimpulkan bahwa korelasi variabel X1 dengan Y “sangat rendah”, X2, X3 dan X4 dengan Y “tinggi”. Lebih lanjut, koefisen determinasi berganda (R2) atau R squared = 0,560 berarti secara bersama-sama 56 % perubahan variabel Y dapat dijelaskan oleh variabel X1, X2 X3, dan X4.
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Monguió, M., I. Negueruela, A. Marco, C. González-Fernández, J. Alonso-Santiago, M. T. Costado, L. Casamiquela i in. "The young open cluster NGC 7067 using Strömgren photometry". Monthly Notices of the Royal Astronomical Society 466, nr 3 (17.12.2016): 3636–47. http://dx.doi.org/10.1093/mnras/stw3302.
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Abstract NGC 7067 is a young open cluster located in the direction between the first and the second Galactic quadrants and close to the Perseus spiral arm. This makes it useful for studies of the nature of the Milky Way spiral arms. Strömgren photometry taken with the Wide Field Camera at the Isaac Newton Telescope allowed us to compute individual physical parameters for the observed stars and hence to derive the cluster's physical parameters. Spectra from the 1.93-m telescope at the Observatoire de Haute-Provence helped to check and improve the results. We obtained photometry for 1233 stars, individual physical parameters for 515 and spectra for 9 of them. The 139 selected cluster members lead to a cluster distance of 4.4 ± 0.4 kpc, with an age below log10(t(yr)) = 7.3 and a present mass of 1260 ± 160 M⊙. The morphology of the data reveals that the centre of the cluster is at (α, δ) = (21: 24: 13.69, +48: 00: 39.2) J2000, with a radius of 6.1 arcmin. Strömgren and spectroscopic data allowed us to improve the previous parameters available for the cluster in the literature.
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Muhtadin, Muhammad Akhsanul, Manal Hendawi, Achmad Patoni i Ahmad Tanzeh. "Students Persistence in The Pondok Lirboyo: A Mixed Methods Study". Nazhruna: Jurnal Pendidikan Islam 6, nr 2 (16.03.2023): 207–25. http://dx.doi.org/10.31538/nzh.v6i2.3019.
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This study seeks to identify the effect of internal components, such as (1) self-efficacy and (2) curriculum perceptions, as well as external factors, such as (3) institutional environment and (4) students' finances. This study employs a sequential model and a mixed-methods, explanatory methodology, namely quantitative research followed by qualitative research. Based on Isaac Michael's methodology, this study's respondents were the school (Pondok) and the students (santri) in Pondok Lirboyo with a total sample size of 286 samples. The analysis of this study employs multiple regression using the t-test and F-test, followed by the Determination Test (R2) to demonstrate the null hypothesis. The results of this study's analysis indicate that (1) there is a positive and significant direct effect on student persistence, (2) there is a positive and significant direct effect on curriculum perceptions on student persistence, (3) there is a positive and significant direct effect on the institutional environment on student persistence, (4) there is a positive and significant direct effect on student (santri) finance on student persistence, (5) there is a substantial regressive effect on student persistence, and (6) there is a substantial regressive effect on the student persistence.
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Ekkart, Rudolf E. O. "Jan Cornelisz. van 't Woudt als portretschilder". Oud Holland - Quarterly for Dutch Art History 103, nr 4 (1989): 223–42. http://dx.doi.org/10.1163/187501789x00176.
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AbstractIn 1986 B. W. F. van Riemsdijk published an article on the painter/draughtsman Jan Cornelisz. van't Woudt, better known as Woudanus. As well as providing biographical particulars, the article dwelt on some of the artist's paintings and various copper engravings after his designs. Archive research enables us to supplement these biographical details. Jan Cornelisz. is thought to have been born around 1565-1570 in Het Woudt, a village near Delft. He was probably a pupil of the Delft artist Jacob Willemsz. Delff the Elder, whose influence is most apparent in his work. Shortly after his marriage in 1594, Woudanus moved to Leiden, where his bride came from and where Isaac Claesz. van Swanenburg 1537-1614) was a leading painter of the day. For some tweny years Woudanus worked as a painter and print designer in Leiden, where he died in 1615. Of the engravings after his designs, four depicting university institutions - executed by Willem van Swanenburg - are best known. One signed painting by Woudanus is extant: The Surrender of Weinsberg of 1603, in the Lakenhal Museum in Leiden (fig. 1). This large painting corresponds remarkably with the stage directions for a play on the same subject written by Jacob Duym for the local dramatic society, or rederijkerskamer, published three years previously. Woudanus' painting was undoubtedly influenced by the directions in Duym's play. Among the figures in the foreground (figs. 2 and 3) are several portraits, including likenesses of the painter, Dirck Volckertsz. Coornhert and, presumably, Jacob Duym. The rendering of The Surrender of Weinsberg displays a number of special characteristics, such as the use of light and dark patches and the depiction of the hands. There are strong grounds for attributing the blazon of the Leiden Chamber of Rhetoric, D'Oraigne Lelie, of 1606 (fig.4), to Woudanus. Archivalia (see the Appendix) and prints (figs. 5 and 6) show that the artist also painted portraits. A systematic investigation into Leiden portraiture of the late 16th and early 17th century yielded portraits with the same characteristics as The Surrcnder of Weinsberg and which can duly be attributed to Woudanus. The portraits in question are of the Leiden merchant and regent, Huyg van Nes, and his wife, painted in 1606 (figs. 7 and 8), and of another citizen of Leiden, a dyer and former mayor, Claes Willemsz. van Warmondt, and his wife, painted in 1607 (figs. 9 and 10). In view of the discrepancy in size, the latter two portraits are not companion pieces; each is probably half of another pair painted that year in a different format but otherwise identical. The four portraits bear a strong stylistic resemblance to the work of Woudanus' putative teacher Delff. A fifth portrait of 1596, very likely a female member of the Stalpert van Wiele family (fig. 11), may be added to the group with certainty. Differently set up but technically entirely in keeping with Woudanus' work is the profile portrait of the famous scholar Josephus Justus Scaliger in the Leiden Senate Room, dating from 1608 or 1609 (fig. 12). Although not a particularly important artist, Jan Cornelisz. van 't Woudt played a significant role in Leiden between 1596 and 1615 as a history and portrait painter and as a designer of prints depicting a variety of subjects.
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Uddin, Moh Syafi', Tumini Tumini i Junaidi Junaidi. "Pengaruh Kualitas Produk, Harga Dan Word Of Mouth Terhadap Kepuasan Pembelian Di CV. Pia Manalagi Kota Probolinggo". JUMAD : Journal Management, Accounting, & Digital Business 1, nr 2 (28.04.2023): 251–60. http://dx.doi.org/10.51747/jumad.v1i2.1380.
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Banyak aspek yang menjadi pertimbangan seorang pelanggan untuk memilih suatu produk, misalnya Word Of Mouth yang ada dan kualitas produknya. Setiap membangun sebuah perusahaan pada umumnya semua perusahaan ingin berhasil dalam menjalankan usahanya. Jenis penelitian yang digunakan adalah deskriptiff kuantitatif, dengan variabel independen (bebas) Kualitas Produk (X1), Harga (X2) dan Word Of Mouth (X3) serta variabel dependen (terikat) Keputusan Pembelian(Y). Populasi dalam penelitian ini yang digunakan adalah para Pelanggan. penentuan pengambilan jumlah responden (sampel) yang digunakan adalah tabel Isaac dan Michael sedangkan Teknik sampling yang digunakan adalah Non probability sampling. Sumber data meliputi : (1) data primer, (2) data Sekunder. Metode analisis data yang digunakan meliputi : statistik deskriptif, uji validitas dan reabilitas, uji asumsi klasik, regresi linier berganda, koefisien determinasi (R Square), pengujian hipotesis yang terdiri dari uji t dan uji F. Hasil penelitian dari uji simultan kuliatas produk (X1), harga (X2) dan word of mouth (X3) berpengaruh signifikan terhadap kepuasan konsumen (Y) dari perhtungan uji F peroleh nilai Fhitung = 24,931. Selain itu dariuji parsial menunjukan bahwa kualitas produk (X1) berpengaruh signifikan terhadap Keputusan pembelian (Y) dengan nilai thitung = 2,584, harga (X2) berpengaruh signifikan terhadap Keputusan pembelian (Y) dengan nilai thitung = 4,381 dan word of mouth (X3) berpengaruh signifikan terhadap Keputusan pembelian (Y) dengan nilai thitung = 3,672.
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McKim, Donald K. "Isaac Watts. Reason, passion and the revival of religion. By Graham Beynon . (Studies in English Theology.) Pp. viii + 220. London–New York: Bloomsbury T&T Clark, 2016. £95. 978 0 5676 7013 7". Journal of Ecclesiastical History 68, nr 4 (11.09.2017): 886–88. http://dx.doi.org/10.1017/s0022046917000902.
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Wistiani, W., Dewi Ratih, M. Mulyono i Saekhol Bakri. "The Effects of Zinc Supplementation on Immune Response of Obese Children With Family History of Atopy". Journal of Biomedicine and Translational Research 4, nr 2 (31.12.2018): 27. http://dx.doi.org/10.14710/jbtr.v4i2.3520.
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Introduction: Obesity is associated with low-grade chronic inflammation and disbalance between cytokine production of T helper1 and T helper2 cells. Zinc plays role in balancing immune response, has anti-oxidant and anti-inflammation activities; its deficiency also common in obesity. The role of zinc supplementation in children with obesity with risk of atopy needs to be elucidated.Materials and Method: We performed randomized controlled trial double-blind to investigate the effect of daily 15 mg zinc supplementation for 6 weeks in children aged 13 to 14 years old with obese who has family history of atopy. Subjects were divided into group of zinc supplementation and placebo, recruited from junior high schools from Semarang municipality, performed during periods from January to December 2013. Plasma zinc concentration, leptin, immunoglobulin-E (Ig-E), interferon-γ (IFN-γ), interleukin-4 (IL-4) were measured, also body weight, height and ISAAC questionnaire to recruit subjects with family history of atopy.Result: There were 36 subjects. The concentration of zinc serum, Ig-E, IFN-γ, and IL-4 of two groups before supplementation were not significantly different (p>0.05). Zinc supplementation increase the mean level of zinc concentration on treatment group compare to placebo group (27.74+11.80 vs 3.47+2.55, p=0.000). The concentration of Ig-E, IFN-γ and IL-4 serum were decreased at treatment group (15.5+20.46 vs 20.02+38.02, p=0.613), (1.82+3.59 vs 0.911+3.51, p=0.174), and (4.76+6.49 vs 2.44+4.41, p=0.085) respectively. Conclusion: Zinc supplementation increased the level of zinc serum concentration of obese children and decreased the risk of atopy.
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Brackenridge, J. Bruce. "Isaac Newton. The Preliminary Manuscripts for Isaac Newton's 1687 Principia 1684–1686. Facsimilies of the Original Autographs, now in Cambridge University Library, with an Introduction by D. T. Whiteside. Cambridge: Cambridge University Press, 1989. Pp. xxi + 246. ISBN 0-521-33499-3. £65.00. $115.00." British Journal for the History of Science 25, nr 3 (wrzesień 1992): 364–65. http://dx.doi.org/10.1017/s0007087400029253.
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Rustandi, Bella Melinda, i Candra Vionela Merdiana. "ANALISIS PENGARUH PROMOSI JABATAN, MUTASI, DAN PELATIHAN TERHADAP PENGEMBANGAN KARIR KARYAWAN DISTRIK NAVIGASI KELAS III CILACAP". Jurnal Fokus Manajemen Bisnis 9, nr 1 (15.01.2020): 49. http://dx.doi.org/10.12928/fokus.v9i1.1549.
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This study aims to determine the effect of job promotion, mutation and training on employee career development at “Distrik Navigasi Kelas III Cilacap". This research is a survey research using a questionnaire as an instrument. The population in this study consisted of 146 employees who worked at “Distrik Navigasi Kelas III Cilacap”. The sample in this study amounted to 115 employees “Distrik Navigasi Kelas III Cilacap”. The determination of sample size in this study uses the Isaac and Michael Tables (with an error tolerance of 5%). The sampling technique uses purposive sampling, which is sampling from the population with certain considerations. Test the validity of the instrument using CFA, while the reliability test results using Cronbach Alpha. The analysis technique used is multiple regression analysis techniques, and Hypothesis Test using F Test and t Test. The results of this study indicate that the variables of promotion, transfer and training simultaneously or jointly have a significant effect on employee career development in “Distrik Navigasi Kelas III Cilacap”. Job promotion variables have a significant effect on the career development of employees of the “Distrik Navigasi Kelas III Cilacap”. Mutation variables have no significant effect on career development of “Distrik Navigasi Kelas III Cilacap” employees. And the training variables have a significant influence on the career development of the “Distrik Navigasi Kelas III Cilacap”.
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Mokae, Sabata-mpo. "The public and private life of Sol Plaatje". Historia 63, nr 1 (3.11.2021): 1–10. http://dx.doi.org/10.17159/2309-8392/2021/v66n1a6.
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There has been an upswing in attention to South African biography in the past few decades, with a welcome trend towards remaking or revising the canon of important figures from the South African past. This has included edited collections of the works of prominent individuals, and notable among these have been early-twentieth century black African politicians and writers. Historical Publications Southern Africa (renamed from its previous moniker, the Van Riebeeck Society) has published four edited collections of the writings of such individuals since 2008, including Isaac Williams Wauchope, Richard Victor Solope Thema, and A.B. Xuma. A Life in Letters, a collection of Solomon T. Plaatje's correspondence, is the fourth such volume in just over a decade. There are 260 letters, written from 1896 to 1932, included in the book. Most are in English, but some are in Setswana, Dutch/Afrikaans, and a few are in German. Although a number of the letters are from the collections of the Cullen Library at the University of the Witwatersrand, the reviewer counted twenty-seven different collections across three continents. The book is thus an excellent resource not only for historians, but also for students and the general public who now have access to a wide range of Plaatje's thoughts, opinions, and emotions that are evident in his letters.
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Setyawati, Aswanti, i Husni Hasan. "EFFECT OF SERVICE QUALITY AND FACILITIES ON COMMUTERLINE TRAIN USER SATISFACTION: A CASE OF INDONESIA". Journal of Economics, Management, Entrepreneurship, and Business (JEMEB) 1, nr 2 (26.11.2021): 187–200. http://dx.doi.org/10.52909/jemeb.v1i2.48.
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The effect of service quality and facilities on user satisfaction of JABODETABEK Commuter Line Train. The purpose of this study was to see how the influence of service quality and facilities on user satisfaction of Jabodetabek commuter line trains. The method used in this research is quantitative research which is descriptive and verification in nature. Data collection techniques using questionnaires, observation and literature study. While the data analysis method used in this research is validity test, reliability test, path analysis, t test and F test using SPSS.23.0. The sampling technique used was non-probability sampling, purposive sampling type. The number of users sampled is a population of 336,045 passengers with a 5% MOE at a 95% confidence level based on the Isaac & Michael formula is S = 348 samples. According to analysis carried out it can be concluded quality of service effect amounted to 38.00% on user satisfaction Commuter Line, influential facilities for 40.30% of the Commuter Line user satisfaction and jointly quality of service and facility has an influence of 78.30% on Commuter Line Train user satisfaction. Based on the results of this study, the steps that need to be taken by the management of PT. KAI is to make efforts to further improve the quality of Commuter Line Train user satisfaction through improving the quality of service (Service Quality) and facilities (Facility / infrastructure).
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Shait, Heddy. "Horizontal or Vertical: Rereading the Space Scheme in Only Yesterday by S. Y. Agnon". AJS Review 39, nr 2 (listopad 2015): 393–406. http://dx.doi.org/10.1017/s0364009415000100.
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Since its publication in 1945, scholarly works on S. Y. Agnon's Only Yesterday(Temol shilshom) have focused on various thematic and poetic aspects of the novel, such as the structure of the plot, the protagonist Isaac Kumer, and the moral and poetic meanings of the novel's ending. Inter alia, scholars have been interested in the geographical spaces presented in the plot, and the protagonist's indecision of whether to settle in Jaffa or Jerusalem, two cities that offer contrasting ways of living. This article offers a new reading of the novel's space scheme in tandem with an analysis of the short story, “The Mines of Falun,” by E. T. A. Hoffman, with which Agnon was familiar, and thus sheds a different light on Kumer's unexpected death at the novel's end. A comparative study of Agnon's and Hoffman's works reveals a similar space scheme that does not emphasize the contrast between two different cities—Jerusalem and Jaffa—but focuses on a single highly significant urban setting—Jerusalem. In Only Yesterday the main conflict is actually between a heavenly Jerusalem and an earthly Jerusalem (Jerusalem of above and below), and not between Jerusalem and Jaffa. Concentrating interest on Jerusalem itself turns the discussion of the novel to the nature of Jewish life in the Land of Israel, an issue that was of great concern to Agnon.
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Walton, N. A., S. R. Pottasch, N. K. Reay i T. Spoelstra. "The Central Star of NGC 7027". Symposium - International Astronomical Union 131 (1989): 301. http://dx.doi.org/10.1017/s0074180900138483.
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We have detected the central star of NGC 7027 by imaging the nebula through a narrow band ‘continuum’ filter onto the IPCS detector at the 2.5m Isaac Newton Telscope. We obtain an apparent visual magnitude for the central star of mv = 17.7 ± 0.5 mags.Assuming that the central star radiates approximately as a blackbody, which is reasonable for the case of a hot star, then Zanstra temperatures for the central star can be calculated. We find TZ(H) = 3.9 × 105K and Tz(HeII) = 2.6 × 105K. Using the correction due to Stasinska & Tylenda (1986) we estimate the central star of NGC 7027 to have a temperature, Teff = 3.1 × 105K.The luminosity and radii are found assuming a distance of d=1.2 kpc., giving L = 12,600 L⊙ and R = 0.039 R⊙. Placing the central star on the Log L - Log T diagram and comparing with evolutionary tracks for central stars with various masses from Wood & Faulkner (1986), indicates that the central star of NGC 7027 must have a mass, M ≥ 0.8 M⊙.Radio observations of NGC 7027 have been taken using the Westerbork Radio Synthesis Telesocpe at 21cm. Self calibration techniques have been employed to give a radio continuum map of high dynamic range. These observations are being compared with a deep optical Hβ map to study the nature of the faint halo seen around NGC 7027 (Atherton et al. 1979)
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González González, Valeria, Sandra Nora González Díaz, Carlos Macouzet Sánchez, Laura Abigail Martínez Manzano, Rosa Ivett Guzmán Avilán i Daniel Verduzco Félix. "Asociación de exposición a humo de camiones con asma en adolescentes de un centro de referencia del noreste de México". Revista Alergia México 70, nr 3 (21.08.2023): 193. http://dx.doi.org/10.29262/ram.v70i3.1290.
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Objetivo: Comparar si los adolescentes que están expuestos a humo de camiones tienen mayor prevalencia de sintomatología de asma contra quienes no están expuestos.
Métodos: Estudio transversal, descriptivo y comparativo. Se incluyeron adolescentes de 13 y 14 años de edad quienes completaron un cuestionario autoinformado. Los sujetos se seleccionaron siguiendo la misma metodología que en la fase III de ISAAC. Se les realizó una encuesta epidemiológica para la presencia de síntomas. Exposición al humo de camiones se definió como el paso de camiones la mayoría del día a percepción del paciente. La distribución fue evaluada con la prueba de Kolmogórov-Smirnov. Comparaciones con prueba de Chi-cuadrada o T de Student, según corresponda. Un valor de p £ 0.05 fue considerado estadísticamente significativo.
Resultados: Se incluyeron un total de 492 pacientes. Las variables demográficas se pueden observar en la Tabla 1. Al realizar la asociación entre los grupos de adolescentes con asma que se encuentran expuestos a humo de camiones se encontró una diferencia significativa en la prevalencia de sintomatología respiratoria y asma (26.0% vs 9.6%, p = 0.000).
Conclusión: Los pacientes adolescentes con asma que se encuentran expuestos al humo de camiones demostraron tener diferencia significativa en la presencia de sintomatología respiratoria y asma en comparación con los pacientes sin exposición.
Palabras clave: Asma, camión, adolescentes, contaminación, humo.
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Mcshane, Joseph. "Isaac T. Hecker: The Diary: Romantic Religion in Ante-Bellum America. Edited by John Farina. Sources of American Spirituality. New York: Paulist Press, 1988. v + 456 pp. $14.95." Church History 59, nr 4 (grudzień 1990): 574–76. http://dx.doi.org/10.2307/3169175.
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Bertolace, Maria do Pilar Carneiro, Eliana Toledo, Patrícia Polis de Oliveira Jorge i Raphael Del Roio Liberatore Junior. "Association between obesity and asthma among teenagers". Sao Paulo Medical Journal 126, nr 5 (wrzesień 2008): 285–87. http://dx.doi.org/10.1590/s1516-31802008000500008.
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CONTEXT AND OBJECTIVE: Obesity and asthma are serious and growing problems. Since adipose tissue produces inflammatory substances, the aim of this study was to estimate the prevalence of asthma among students at schools in São José do Rio Preto (Phase 1), and to corroborate the hypothesis for an association between obesity and asthma among these students (Phase 2). DESIGN AND SETTING: Cross-sectional study at Faculdade de Medicina de São José do Rio Preto (Famerp). METHODS: The study consisted of two successive and dependent stages. Phase I was a cross-sectional study on 4103 randomly selected students (13-14 years old), to determine the prevalence and severity of asthma. Phase II was an analytical cross-sectional study on 431 students (190 asthmatics and 231 non-asthmatics) from Phase I, to evaluate the hypothesis of an association between obesity measured by the body mass index (BMI) and asthma. To diagnose asthma and obesity, the criteria of the International Study of Asthma and Allergies in Childhood (ISAAC) and the chart from the Centers for Disease Control (CDC; 2000) were used. The data were analyzed using Student's t test. RESULTS: We found that 5.6% of the students analyzed in Phase I were asthmatic. The BMI among the asthmatic students (21.84 kg/m²) was higher than the BMI among the non-asthmatics (21.73 kg/m²), although the p value was 0.766. CONCLUSION: In our study group, we did not find any association between increased BMI and the prevalence of asthma.
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Sugandi, Evelyne Austine, Sabilla Saberina i Aggi Panigoro Sarifiyono. "The Role of Perceived Ease of Use and Customer Engagement In Influencing Behavioural Intention to Use Traveloka Paylater". International Journal of Business, Economics, and Social Development 4, nr 1 (2.02.2023): 38–44. http://dx.doi.org/10.46336/ijbesd.v4i1.367.
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The objective of this study were to find out the role of perceived ease of use and customer engagement in influencing behavioural intention to use Traveloka Paylater. Based on the increasing number of paylater services users in Indonesia, as well as the lack of behavioural intention to use Traveloka Paylater as the service from Traveloka, which incidentally is the number one online travel and lifestyle superapp in Indonesia. In this study, data were collected through the online questionnaire distribution to the respondents. The population in this study were users of Traveloka as seen from the number of users who gave ratings on PlayStore. The number of sampels taken based on calculations using Isaac and Michael formulas with a total sample are 271 (two hundred seventy one) respondents. The research method that used in this study is an associative quantitative method with a descriptive and verification approach. The result of the questionnaire distribution were analyzed by multiple regression analysis, coefficient of determination, t-test and F-test. The result of this study showed that: (1) perceived ease of use has a partial influence on behavioural intention to use Traveloka Paylate by 0,536 or 53%r. (2) customer engagement has a partial influence on behavioural intention to use Traveloka Paylater by 0,573 or 57,3%. (3) perceived ease of use and customer engagement has a stimultaneous on behavioural intention to use Traveloka Paylater by 0,680 or 68%.
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Karlina, Cici, i Muhammad Dani Harba. "PENGARUH BAURAN PEMASARAN TERHADAP PEMBELIAN ULANG PRODUK ORIFLAME STUDI PADA JARINGAN YOUNG ENERGETIC SUCCES BUSINESS NETWORK (YESBN) MEMBER ORIFLAME CABANG MEDAN". JURNAL ILMU MANAJEMEN DAN KEWIRAUSAHAAN (JIMK) 2, nr 1 (31.12.2021): 126–32. http://dx.doi.org/10.32696/jimk.v1i2.1003.
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This study aims to determine the effect of the marketing mix on the repurchase of Oriflame products on the Young Energetic Success network The Business Network (YESBN) is a member of the Medan branch of Oriflame. Population in This research is a member of the Young Energetic Success Busines network Network (YESBN), consists of 500 women with a tolerance limit of 10% calculated by Isaac and Michael's calculation formula according to Sugiyono then obtained a sample of 176 respondents with the determination of sample using the Random Sampling technique. The author's data analysis technique used in this research is descriptive quantitative. Data collection in This research was obtained by distributing questionnaires and statistically processed by using the SPSS Version 25 program. From the results of data processing and data analysis with a simple linear regression coefficient that is known as Y =19.226 + 0.441 X, which means, the marketing mix has a significant effect significant to the repurchase variable and from the results of the t-test, count (6.079) > table (1.973); therefore, if the value of count is greater than thetable, then the hypothesis is accepted. So, it can be concluded that the hypothesis that statesvariable (X) has been proven, or in other words, there is a significant effect between thevariable (X) to the variable (Y). Moreover, based on the coefficient test determination of0.419 or with a percentage of 41.9%, the mix marketing effect on repurchase. While othervariables outside this study influenced the remaining 58.1%.
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Lau, S. L., P. W. V. Chan, I. T. Cheng, C. C. Mok, C. Ho, T. T. Cheung, V. W. Lao i in. "POS0488 THE IMPACT OF ACHIEVING EARLY-SUSTAINED REMISSION USING BOOLEAN 2.0 CRITERIA ON PREVENTING FUNCTIONAL IMPAIRMENT IN RHEUMATOID ARTHRITIS". Annals of the Rheumatic Diseases 82, Suppl 1 (30.05.2023): 505.1–506. http://dx.doi.org/10.1136/annrheumdis-2023-eular.6025.
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BackgroundRheumatoid Arthritis (RA) is associated with functional impairment and disability. With the 2022 revision of the Boolean remission criteria, more patients can classified as achieving remission and the revised version also increases the agreement with index-based remission criteria without jeopardising predictive value for radiographic or functional outcomes. Whether achieving sustained Boolean 2.0 remission using a treat-to-target strategy aiming can prevent functional impairment in the long-term measured using the Health Assessment Questionnaires Disability Index (HAQ-DI) would need to be addressed.ObjectivesThis retrospective study aims to explore the impact of sustained remission classified under the revised Boolean 2.0 criteria on HAQ-DI score.MethodsThe data was retrieved from the Clinical Rheumatology Systematic Treat-to-target (T2T) in Asia Leadership (CRYSTAL) registry. Early RA patients with symptoms onset less than 2 years were recruited between 2012-2018. All patients received a treat-to-target treatment strategy aiming at remission and had been followed for 5 years. Swollen joint count (SJC), tender joint count (TJC), Patient global assessment (PtGA), CRP levels, and HAQ-DI were recorded. Patients were classified into two groups: patients achieved Boolean 2.0 remission in both the first and second year (Early-Sustained Remission (ESR) Group), and patients who did not (Non-ESR group).ResultsThe data of 236 patients were retrieved. 57 (24.2%) of them were classified as ESR group and 166 (70.3%) were in Non-ESR group (Table 1). The average HAQ-DI score was lower in the ESR group in the second, third, fourth and fifth year compared to the Non-ESR group withp ≤0.001 [year 1: 0.097 ± 0.218 vs 0.403 ± 0.465; year 2: 0.143 ± 0.267 vs 0.421 ± 0.452; year 3: 0.212 ± 0.339 vs 0.476 ± 0.59; year 4: 0.232 ± 0.358 vs 0.457 ± 0.566] (Figure 1).ConclusionT2T aiming at achieving Boolean 2.0 remission in the first two years could be considered in clinical use for maintaining a lower functional impairment in the long term.References[1]Studenic P, Aletaha D, de Wit M,et al. American College of Rheumatology/EULAR remission criteria for rheumatoid arthritis: 2022 revision.Annals of the Rheumatic Diseases2023;82:74-80.[2]Chow E, Cheng I, Tam L, Hong Kong C. Impact of Achieving Early-sustained Remission on Preventing Long-term Functional Loss in Patients with Early Rheumatoid Arthritis [abstract]. Arthritis Rheumatol. 2019; 71 (suppl 10).Table 1.Baseline demographicsESR group (N=57)Non-ESR group (N=166)pAge51 ± 1354 ± 110.125Sex, male16 (28.1%)34 (20.5%)0.236Disease activity/ disability indexVAS pain score, 0-10042.9 ± 22.749.38 ± 23.30.072VAS patients’ global score, 0-10049.5 ± 24.955.5 ± 22.90.097VAS physicians’ global score48.8 ± 26.155.2 ± 25.50.103Tender joint count, 0-286 ± 58 ± 60.009Swollen joint count, 0-284 ± 35 ± 40.350CRP, mg/L17.1 ± 25.624.1 ± 38.10.201HAQ-DI, 0-30.75 ± 0.620.90 ± 0.650.1211Visual analog scale, range 0-100;2Health Assessment Questionnaire Disability Index, range 0-3Figure 1.The impact of early-sustained Boolean 2.0 remission on HAQ-DI scoreAcknowledgements:NIL.Disclosure of InterestsSze-Lok Lau: None declared, Pui Wing, Vivien CHAN: None declared, Isaac T. Cheng: None declared, Chi Chiu Mok Speakers bureau: GSK and Pfizer, Carmen Ho: None declared, Tommy T Cheung: None declared, Virginia W Lao: None declared, Hin Ting Pang: None declared, Chi Hung To: None declared, Isaac C Yim: None declared, Hoi Yan Ng: None declared, Kitty Yan Kwok: None declared, Ka Lai Lee: None declared, King Yee Shirley Ying: None declared, Man Choi Wan: None declared, Jolly M Lee: None declared, Lai-Shan Tam Consultant of: AbbVie, AstraZenaca, Boehringer Ingelheim, Eli Lilly, Janssen, Pfizer, and Sanofi, Grant/research support from: Amgen, Boehringer Ingelheim, GSK, Janssen, Novartis and Pfizer.
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Xu, Lily, Kaitlyn Saunders, Hildur Knutsdottir, Kenian Chen, Julia Maues, Christine Hodgdon, Evanthia T. Roussos Torres, Sangeetha Reddy, Lin Xu i Isaac Chan. "Abstract GS5-06: InteractPrint predicts clinically meaningful interactions between cancer epithelial cells and immune cells: Lessons from a single-cell breast cancer atlas". Cancer Research 83, nr 5_Supplement (1.03.2023): GS5–06—GS5–06. http://dx.doi.org/10.1158/1538-7445.sabcs22-gs5-06.
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Abstract BACKGROUND: While immunotherapy has revolutionized the treatment of many solid tumors, the efficacy of immunotherapy regimens is comparatively lower in breast cancer. Immunotherapy efficacy is often negatively correlated with intratumor heterogeneity. Novel immunotherapy approaches in breast cancer should leverage how cancer epithelial cell heterogeneity affects immune cells in the tumor microenvironment. However, current definitions of cancer epithelial cell heterogeneity in breast cancer have limited resolution. Single cell RNA-seq (scRNA-seq) provides an unprecedented opportunity to further define cancer epithelial cell heterogeneity and identify how heterogeneity influences interactions with immune cells. METHODS: We generated a novel scRNA-seq dataset of 236,363 cells from 119 primary breast tumors biopsied from 88 patients taken from 8 publicly available datasets, currently the largest published scRNA-seq dataset in breast cancer. To define cancer epithelial cell heterogeneity, we performed unsupervised clustering and supervised clustering based on molecular subtype and expression of clinical target genes on all cancer epithelial cells. This identified 11 gene elements (GEs), which reflect key molecular features that vary between cancer epithelial cells. Receptor-ligand pairing analysis allowed us to determine how cells that highly express each GE interact with various immune cells. We developed InteractPrint, a score to predict the predominant tumor-interacting immune cells, based on the GE composition of an individual patient tumor. RESULTS: In our dataset, 17% of samples were HER2+, 41% were HR+, and 42% were TNBC. This dataset was statistically powered to characterize cancer epithelial cell heterogeneity. For each of the 11 GEs, we predicted interactions with immune cells. Experimentally, GEs with predicted NK cell interactions showed sensitivity to NK cell cytotoxicity. In a spatially resolved transcriptomics dataset, GEs with predicted T cell interactions demonstrated colocalization with CD8+ T cells, while those with limited predicted T cell interactions did not. To infer GE-immune interactions at the patient level (GEs define cell-level interactions), we developed InteractPrint. To validate InteractPrint, we assessed the accuracy of the T cell InteractPrint in predicting response to anti-PD-1 therapy. Across two trials and all breast cancer subtypes, T cell InteractPrint demonstrated significant improvement over PD-L1 in predicting response to anti-PD-1 therapy. In an scRNA-seq dataset of samples from patients treated with pembrolizumab, we observed AUC of 85% (p < 0.005) for T cell InteractPrint vs. 61% (p > 0.05) for PD-L1 in predicting response to anti-PD-1 therapy. In patients treated with paclitaxel + pembrolizumab in the I-SPY 2 trial, we observed AUC of 81% (p < 0.00001) for T cell InteractPrint versus 72% (p = 0.001) for PD-L1. CONCLUSIONS: Our results demonstrate considerable cancer epithelial cell heterogeneity across primary breast tumor samples and clinical subtypes. We defined this heterogeneity and leveraged it to predict immune cell interactions within a patient’s tumor. We developed T cell InteractPrint to capture heterogeneous interactions between cancer epithelial cells and CD8+ T cells. T cell InteractPrint is predictive of response to anti-PD-1 immune checkpoint inhibition at higher AUC than PD-L1. This provides a path forward for the interpretation of cancer epithelial cell heterogeneity in a clinically meaningful way. Citation Format: Lily Xu, Kaitlyn Saunders, Hildur Knutsdottir, Kenian Chen, Julia Maues, Christine Hodgdon, Evanthia T. Roussos Torres, Sangeetha Reddy, Lin Xu, Isaac Chan. InteractPrint predicts clinically meaningful interactions between cancer epithelial cells and immune cells: Lessons from a single-cell breast cancer atlas [abstract]. In: Proceedings of the 2022 San Antonio Breast Cancer Symposium; 2022 Dec 6-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2023;83(5 Suppl):Abstract nr GS5-06.
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Smith, Stephen C. "T. M. Thomas Isaac, Richard W. Franke, and Pyaralal Raghavan, Democracy at Work in an Indian Industrial Cooperative. The Story of Kerala Dinesh Beedi. Ithaca, NY: ILR Press, 1998". Journal of Comparative Economics 27, nr 3 (wrzesień 1999): 576–79. http://dx.doi.org/10.1006/jcec.1999.1584.
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Cieslak, Fabrício, Wendell Arthur Lopes, Antonio José Grande, Paulo Cesar Kussek, Nelson Augusto Rosário Filho i Neiva Leite. "Respostas fisiológicas em adolescentes obesos submetidos à broncoprovocação com solução salina hipertônica". Fisioterapia em Movimento 26, nr 2 (czerwiec 2013): 259–69. http://dx.doi.org/10.1590/s0103-51502013000200003.
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INTRODUÇÃO: A hiper-responsividade brônquica é a resposta do aumento dos mecanismos fisiológicos protetores das vias aéreas em indivíduos atópicos e não atópicos. Além disso, a magnitude da hiperresponsividade aérea apresenta influência conforme o grau de obesidade. OBJETIVO: Avaliar as respostas fisiológicas em adolescentes obesos submetidos a hiper-responsividade brônquica a solução salina hipertônica. MATERIAIS E MÉTODOS: Estudo descritivo, transversal e correlacional composto por 15 adolescentes obesos, de ambos os gêneros. O diagnóstico de asma foi realizado por meio de histórico clínico e questionário ISAAC, e a obesidade pelo IMC acima do percentil 95. Utilizou-se o teste de broncoprovocação por solução salina hipertônica para avaliação da hiper-responsividade brônquica, considerando positiva uma diminuição do volume expiratório forçado no primeiro segundo (VEF1) > 15% do valor pré-solução salina e a intensidade da hiper-responsividade brônquica foi calculada pela queda percentual máxima do VEF1 (% Queda máxVEF1). Foram utilizados o teste t independente ou U de Mann-Whitney e a correlação de Spearman rho (p < 0,05). RESULTADOS: Não foram encontradas diferenças significativas entre os asmáticos e não asmáticos para as variáveis antropométricas, espirométricas, lipídicas e hemodinâmicas. Verificaram-se moderadas correlações positivas e diferenças significativas entre o % Queda máxVEF1 com o IMC (p = 0,040) e IMC escore-Z (p = 0,028). Foram detectadas correlações negativas e diferenças significativas para a Queda máxVEF1 e leucócitos (p = 0,005) e para o % Queda máxVEF1 com o sulfato de dehidropiandrosterona (p = 0,032). CONCLUSÃO: Pode-se concluir que os adolescentes obesos submetidos a hiper-responsividade brônquica apresentam alterações espirométricas que estão associadas às inflamações sistêmicas da obesidade.
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Mylabathula, Preteesh L., Shruthi Nooka, Anas Alkhani, James Zhu, Ashley Vu, Riyasat Ali, Varshini Ramasamy Balasubramanian, Isaac Chan i Sangeetha M. Reddy. "Abstract 5314: Improved breast cancer tumor control with addition of CD40 agonist and Flt3 ligand to pegylated liposomal doxorubicin is only partially mediated by CD8 T cells". Cancer Research 84, nr 6_Supplement (22.03.2024): 5314. http://dx.doi.org/10.1158/1538-7445.am2024-5314.
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Abstract Background: There is a need for improved immunotherapy strategies beyond current FDA approved treatments for triple negative breast cancer. Defective antigen presentation has been shown to play a contributory role in deficient anti-tumor immunity in breast cancers. Flt3 ligand (Flt3L) is a growth factor that increases differentiation into DC1 dendritic cells. CD40 agonist (CD40a) activates all 3 classes of antigen presenting cells - DCs, B cells, and macrophages. Synergy with chemotherapy and CD40a has been seen in other cancers but not explored in breast cancers. Methods: C57BL/6 mice (aged 6-8 weeks) were injected with 150,000 E0771 breast cancer cells within the mammary fat pad. Tumors were allowed to grow to a volume of ~50 mm3 before randomization into treatment groups. Mice were treated with triplet therapy of pegylated liposomal doxorubicin (PLD) via tail vein followed by Flt3L intraperitoneal (IP) daily for 5 days and CD40a IP 1 week later as well as monotherapy and doublet therapy controls. Tumor growth and survival were monitored throughout the experiment. Tumors were harvested for single cell RNA sequencing (scRNAseq) and immunohistochemistry. To further study subset specific effects on efficacy of the immunotherapy, CD8 and CD4 T-cells were systemically depleted with anti-CD8 and anti-CD4 antibodies administered IP every 4 days starting 2 days before PLD treatment. Results: Triplet therapy led to improved tumor control compared to no treatment, monotherapy, and doublet controls (p<0.0001). Increased tumor infiltration with CD8 T cells was observed with triplet therapy via immunohistochemistry. scRNAseq showed increased cDC1 subset with Flt3L treatment. Contrastingly, CD40a decreased DC subsets likely due to activation and emigration out of the tumor, remodeled macrophage populations, and decreased T regulatory cells. CD8 depletion led to faster tumor growth whereas CD4 depletion reduced tumor growth. Triplet therapy maintained efficacy over PLD with both CD8 and CD4 depletion but showed reduced magnitude of benefit with CD8 T cell depletion suggesting a partial CD8 mediated process. CD4 T cell depletion did not hinder triplet therapy efficacy compared to PLD but depletion further enhanced tumor control in combination with triplet therapy, with 20% (2/10) of animals achieving complete regression. Conclusion: Triplet therapy with PLD, Flt3L, and CD40a improved tumor control and survival in syngeneic E0771 breast cancer mouse model. Added benefit of immunotherapy to PLD is partially CD8 T cell mediated. CD4 depletion further enhances tumor control in combination with triplet therapy. Experiments to explore the interactive effect of triplet therapy with other pertinent immune subsets are ongoing. A clinical trial with this combination in metastatic triple negative breast cancer patients is open and recruiting (NCT05029999). Citation Format: Preteesh L. Mylabathula, Shruthi Nooka, Anas Alkhani, James Zhu, Ashley Vu, Riyasat Ali, Varshini Ramasamy Balasubramanian, Isaac Chan, Sangeetha M. Reddy. Improved breast cancer tumor control with addition of CD40 agonist and Flt3 ligand to pegylated liposomal doxorubicin is only partially mediated by CD8 T cells [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2024; Part 1 (Regular Abstracts); 2024 Apr 5-10; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2024;84(6_Suppl):Abstract nr 5314.
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Chen, Shuming, Seoho Lee, Tracee L. McMiller, Isaac Morales, Preethi Sankaran, Brian Francica, Robert D. Leone, Tom W. Dubensky i Suzanne L. Topalian. "Abstract 4159: The COX-2/PGE2 pathway as a mediator of resistance to anti-PD-1 therapy". Cancer Research 83, nr 7_Supplement (4.04.2023): 4159. http://dx.doi.org/10.1158/1538-7445.am2023-4159.
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Abstract Background: We previously found upregulation of the cyclooxygenase-2/prostaglandin E2 (COX-2/PGE2) pathway in the tumor microenvironment (TME) of cancer types that respond poorly to anti-PD-1 therapy, and showed that TME-resident cytokines such as IL-1B induce COX-2 expression in human tumor and myeloid cells. To investigate a potential role for COX-2/PGE2 in anti-PD-1 resistance, we studied PGE2-mediated effects on human myeloid and T cells and their dependence on prostaglandin (EP) receptor signaling. Methods: Monocytes (Monos) and T cells were enriched from normal donor peripheral blood by negative selection. PGE2 effects were tested on Monos activated with IFN-g (PD-L1 expression; FACS) or LPS (cytokine secretion; ELISA). PGE2 effects on monocytic dendritic cells (DCs) generated with GM-CSF+IL-4 and matured with CD40L were assessed by phenotyping for costimulatory molecules (CD80, CD86) and subpopulation markers (CD14, CD16, CD83). T cells activated with anti-CD3/CD28 +/- PGE2 for 2-6 days were assessed for expression of CD25, CD69, CD107a, CD137, OX40, GITR, LAG-3, PD-1, PD-1, PD-L1 and TIM3 (FACS); proliferation markers (Ki67, CFSE; FACS); cytokine secretion (IFN-g, IL-2, IL-10, TGF-b; ELISA); and metabolic function (Seahorse assay). In some experiments, cells were pre-incubated with inhibitors of EP2 (PF-04418948), EP4 (ONO-AE3-208), or the dual inhibitor TPST-1495 (Tempest Therapeutics). Results: Myeloid cell functions were suppressed by PGE2, which reduced IFNg-induced PD-L1 expression and modulated LPS-induced cytokine secretion. Furthermore, PGE2 inhibited DC maturation, evidenced by persistent CD14 and CD16 expression and a decreased CD83+ subset. In CD4 and CD8 T cells activated with anti-CD3/CD28, PGE2 reduced expression of CD25 and CD69 (early activation markers), CD107a (cytolytic potential), Ki67 (cell proliferation), co-stimulatory molecules (CD137, OX40, GITR) and checkpoint molecules (LAG-3, PD-1, PD-L1, TIM3) in a dose-dependent manner. PGE2 also reduced the CFSE-low (proliferating) population in activated CD4, CD8 and Treg cells. Secretion of proinflammatory cytokines IFN-g and IL-2, and inhibitory cytokines IL-10 and TGF-b from activated T cells was also suppressed by PGE2. These effects were specifically reversed by chemical inhibitors of EP2 and/or EP4. PGE2 exposure at the time of T cell activation was associated with depressed mitochondrial oxidation and cellular glycolysis, suggesting global effects on T cell metabolism. Conclusion: Understanding and preventing anti-PD-1 resistance is a critical goal in oncology. Our results suggest that the COX-2/PGE2 pathway exerts immunosuppressive effects on myeloid and T cells via the EP2 and EP4 receptors. COX-2 and PD-L1 are distinct immune checkpoints, providing a rationale to test anti-PD-1 in conjunction with COX-2 pathway inhibitors such as IL-1B antagonists and highly specific EP2 and EP4 inhibitors in patients with cancer. Citation Format: Shuming Chen, Seoho Lee, Tracee L. McMiller, Isaac Morales, Preethi Sankaran, Brian Francica, Robert D. Leone, Tom W. Dubensky, Suzanne L. Topalian. The COX-2/PGE2 pathway as a mediator of resistance to anti-PD-1 therapy. [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 4159.
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Ogbolosingha, Samuel Joseph, i Emmanuel Olorunleke Eseyin. "Educational Resource Needs and Access to Tertiary Education among People with Disability in Bayelsa State". British Journal of Education 12, nr 1 (15.01.2024): 18–40. http://dx.doi.org/10.37745/bje.2013/vol12n11840.
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The paper investigated educational resource needs and access to tertiary education among people with disability in Bayelsa State. Three research questions were raised and three hypotheses tested in the study. Mixed method approach was adopted in the study while 165 respondents consisting 160 persons with disability, four Deans of Student Affairs and an executive of Joint National Association of Persons with Disabilities (JONAPWD) in Bayelsa State were sampled for the study using multistage sampling technique. Respondents were selected from within and outside four randomly selected tertiary institutions namely; Bayelsa Medical University (Yenagoa LGA), Federal University Otuoke (Ogbia LGA), Niger Delta University (Southern Ijaw LGA) and Isaac Jasper Boro College of Education (Sagbama LGA). Instruments used for data collection were questionnaire for the persons with disability as well as Focus Group Discussion while five Key Informant Interviews (KIIs)was conducted with the other respondents. Data collected quantitatively were analyzed using descriptive statistics such as mean, standard deviation and t-test while the qualitative data was analyzed using content and thematic analysis. The finding of the study indicated that financial resource, policy intervention and assistive technology were the priority educational resource need of the respondents. Inaccessibility to tertiary education has implication on the employment prospects and human rights of the respondents and this can only be corrected through appropriate policies, better infrastructure among other strategies. There were differences between the opinion of students and non-students on the issues interrogated. It was recommended that the government should collaborate with school administrators to create a fund for persons with disability who wish to acquire tertiary education across all spheres.