Rozprawy doktorskie: „Integrated Magnetic Actuation System”

1

Leuschke, Rainer. "Motor integrated actuation for a flywheel energy storage system /". Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/7113.

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Linda, Quazi Tanzil Afroze. "Developing Magnetic resonance elastography (MRE) breast actuation system for detecting breast cancer". Thesis, University of Canterbury. Mechanical Engineering, 2012. http://hdl.handle.net/10092/6575.

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It is well known in medicine that changes in tissue elasticity may be related to pathological phenomena such as cancer and other disease. Physicians routinely use palpation as means of inspecting the thyroid, prostate, and breast, where a palpably hard mass can often indicate the presence of a malignant lesion. Magnetic Resonance Elastography (MRE) has emerged as a relatively new elasticity imaging technique which can be used to spatially map and measure displacement patterns resulting from harmonic shear-wave propagation in soft tissue. Displacement fields are then used in reconstructing the tissue’s elastic property distributions. The feasibility of using MRE as a noninvasive means of characterizing the mechanical properties of silicone phantom mimicking human breast, was investigated though experiments involving MRE acquisitions of four phantoms. To achieve sufficient excitation of the phantom tissue, an acoustic actuator was developed. The results of these studies have shown the MRE acquisition to be successful in capturing sufficient data for elastic parameter reconstruction. Another different type of actuator has been developed and tested in the laboratory. The results show the potential for future use of this actuator in MRE experiments.

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3

CHOI, JIN-WOO. "MAGNETIC PARTICLE SEPARATORS AND INTEGRATED BIOFILTERS FOR MAGNETIC BEAD-BASED BIOCHEMICAL DETECTION SYSTEM". University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin990796344.

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Kiermaier, Josef [Verfasser]. "Integrated Nanomagnetic Logic System in Perpendicular Magnetic Media / Josef Kiermaier". Aachen : Shaker, 2014. http://d-nb.info/1049380894/34.

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Stegen, Sascha. "Development of an Integrated Magnetic System Assisted by Electromagnetic Simulation". Thesis, Griffith University, 2012. http://hdl.handle.net/10072/365703.

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In DC/DC converter systems, power electronic circuits are reaching switching efficiencies close to 100 percent nowadays. Thus, most of the energy loss appears inside the passive magnetic circuit of the converter, which at the same time is the component that requires most space in the system. In order to battle this issue, research during the last century has been focused on planarization, hybridization and integration techniques with the goal to achieve higher efficiencies and decrease the profile and volume of the devices. In addition, higher frequencies have been applied to achieve a higher power density of the magnetic systems, but with the negative consequence of stronger parasitic effects such as proximity and skin effects inside the magnetic circuit. This thesis deals with the development of an integrated magnetic system in a L-C-T (Inductor-Capacitor-Transformer) configuration, with the assistance of Finite Element Method (FEM) computer modeling, which is supportively used to accelerate the development process. Computational simulation method is used to indicate and address the physical issues, which cannot be identified with conventional measurement methods.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Griffith School of Engineering
Science, Environment, Engineering and Technology
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6

Bowers, Brian J. (Brian Jeffrey). "Integrated cryogenic refrigeration system design for superconducting magnetic energy storage systems". Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/42681.

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Munir, Ahsan. "Magnetic Nanoparticle Enhanced Actuation Strategy for mixing, separation, and detection of biomolecules in a Microfluidic Lab-on-a-Chip System". Digital WPI, 2012. https://digitalcommons.wpi.edu/etd-dissertations/289.

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Magnetic nanoparticle (MNP) combined with biomolecules in a microfluidic system can be efficiently used in various applications such as mixing, pre-concentration, separation and detection. They can be either integrated for point-of care applications or used individually in the area of bio-defense, drug delivery, medical diagnostics, and pharmaceutical development. The interaction of magnetic fields with magnetic nanoparticles in microfluidic flows will allow simplifying the complexity of the present generation separation and detection systems. The ability to understand the dynamics of these interactions is a prerequisite for designing and developing more efficient systems. Therefore, in this work proof-of-concept experiments are combined with advanced numerical simulation to design, develop and optimize the magnetic microfluidic systems for mixing, separation and detection. Different strategies to combine magnetism with microfluidic technology are explored; a time-dependent magnetic actuation is used for efficiently mixing low volume of samples whereas tangential microfluidic channels were fabricated to demonstrate a simple low cost magnetic switching for continuous separation of biomolecules. A simple low cost generic microfluidic platform is developed using assembly of readily available permanent magnets and electromagnets. Microfluidic channels were fabricated at much lower cost and with a faster construction time using our in-house developed micromolding technique that does not require a clean room. Residence-time distribution (RTD) analysis obtained using dynamic light scattering data from samples was successfully used for the first time in microfluidic system to characterize the performance. Both advanced multiphysics finite element models and proof of concept experimentation demonstrates that MNPs when tagged with biomolecules can be easily manipulated within the microchannel. They can be precisely captured, separated or detected with high efficiency and ease of operation. Presence of MNPs together with time-dependent magnetic actuation also helps in mixing as well as tagging biomolecules on chip, which is useful for point-of-care applications. The advanced mathematical model that takes into account mass and momentum transport, convection & diffusion, magnetic body forces acting on magnetic nanoparticles further demonstrates that the performance of microfluidic surface-based bio-assay can be increased by incorporating the idea of magnetic actuation. The numerical simulations were helpful in testing and optimizing key design parameters and demonstrated that fluid flow rate, magnetic field strength, and magnetic nanoparticle size had dramatic impact on the performance of microfluidic systems studied. This work will also emphasize the importance of considering magnetic nanoparticles interactions for a complete design of magnetic nanoparticle-based Lab-on-a-chip system where all the laboratory unit operations can be easily integrated. The strategy demonstrated in this work will not only be easy to implement but also allows for versatile biochip design rules and provides a simple approach to integrate external elements for enhancing mixing, separation and detection of biomolecules. The vast applications of this novel concept studied in this work demonstrate its potential of to be applied to other kinds of on-chip immunoassays in future. We think that the possibility of integrating magnetism with microfluidic-based bioassay on a disposable chip is a very promising and versatile approach for point-of care diagnostics especially in resource-limited settings.

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Shihadeh, Fadi Easa. "Optimized and integrated alignment system for functional proton radiosurgery". CSUSB ScholarWorks, 2007. https://scholarworks.lib.csusb.edu/etd-project/3258.

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In this thesis work, a system for proton beam alignment was studied and optimized in many of its functional areas. The resulting system was named Positioning Alignment Control System (PACS). The PACS system is an integrated and efficient system as a result of the work done on it in the course of this thesis work.

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9

Van, Rensburg Jacques Jansen. "An integrated controller for an active magnetic bearing system / by Jacques Jansen van Rensburg". Thesis, North-West University, 2007. http://hdl.handle.net/10394/2306.

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Zheng, Yi. "Biological Agent Sensing Integrated Circuit (BASIC): A New Complementary Metal-oxide-semiconductor (CMOS) Magnetic Biosensor System". Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/48892.

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Fast and accurate diagnosis is always in demand by modern medical professionals and in the area of national defense. At present, limitations of testing speed, sample conditions, and levels of precision exist under current technologies, which are usually slow and involve testing the specimen under laboratory conditions. Typically, these methods also involve several biochemical processing steps and subsequent detection of low energy luminescence or electrical changes, all of which reduce the speed of the test as well as limit the precision. In order to solve these problems and improve the sensing performance, this project proposes an innovative CMOS magnetic biological sensor system for rapidly testing the presence of potential pathogens and bioterrorism agents (zoonotic microorganisms) both in specimens and especially in the environment. The sensor uses an electromagnetic detection mechanism to measure changes in the number of microorganisms--tagged by iron nanoparticles--that are placed on the surface of an integrated circuit (IC) chip. Measured magnetic effects are transformed into electronic signals that count the number and type of organisms present. This biosensor introduces a novel design of a conical-shaped inductor, which achieves ultra-accuracy of sensing biological pathogens. The whole system is integrated on a single chip based on the fabrication process of IBM 180 nm (CMOS_IBM_7RF), which makes the sensor small-sized, portable, high speed, and low cost. The results of designing, simulating, and fabricating the sensor are reported in this dissertation.
Ph. D.

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11

Majid, Mamun Sirajul. "An Integrated Point of Sales System with Magnetic Stripe Card Reader for Binary-based Multi-level Marketing (MLM) Business System". Thesis, Uppsala University, Department of Information Technology, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-129456.

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Destiny-2000 (Pvt.) Ltd. is a Multi-Level Marketing (MLM) company operating in Bangladesh which has adopted the Binary System of MLM. Binary systems are a multilevel marketing compensation plan which allows distributors to have only two front-line distributors. Everyone else goes beneath those people. The thing that determines whether one can get a commission from a person is not what level he is on, but rather how much purchase volume is generated in the levels between one and that person. Destiny-2000 has more than 130 Net offices (so called Net office which is bigger than Branch office) / Branch offices. As of 4th October 2007, the total number of distributors/ members is 1,322,361.

To make certain level of profit to keep the sales commission and incentive amount attractive for current and prospective distributors the minimum purchase volume for joining the sales network is moderately high by Bangladesh standard.

Destiny-2000 (Pvt.) Ltd. is exploring several options to attract their prospective and current members/ distributors. To this extend, the IPOS developed in this project reduces the one-time purchase burden for prospective members and allows current members to utilize their accumulated points by conveniently purchasing products from a shopping mall.

An Integrated Point of Sales (IPOS) System with Magnetic Stripe Card Reader application has developed based on shopping mall, which will be demonstrated using screen shots.

The complete system in this project, consist of several programs using Visual Studio.Net, C#, Visual Fox Pro, an SQL Database like MS SQL Server 2000, One GUI application, a set of reports using Crystal Report and magnetic stripe card reader, Point Privilege Card(PPC), Barcode Scanner etc.

Keywords: PPC, MLM, IPOS, Software, Development, Magnetic Stripe Card Reader, Barcode Scanner, Visual Studio.Net, C#, Visual Fox Pro, Crystal Report, MS SQL Server 2000, Binary System, Database, Point Privilege Card, Destiny Point, Distributor, Member

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12

Howes, Stuart C. "Design of a noninvasive system for the evaluation of collagen scaffolds using MRI". Link to electronic thesis, 2007. http://www.wpi.edu/Pubs/ETD/Available/etd-052507-131736/.

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13

Gobbalipur, Ranganath Jayanth. "Multi-axis probing system for nano-metrology". The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1229908979.

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14

Yang, Bo. "Topology investigation of front end DC/DC converter for distributed power system". Diss., Virginia Tech, 2003. http://hdl.handle.net/10919/28982.

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With the fast advance in VLSI technology, smaller, more powerful digital system is available. It requires power supply with higher power density, lower profile and higher efficiency. PWM topologies have been widely used for this application. Unfortunately, hold up time requirement put huge penalties on the performance of these topologies. Also, high switching loss limited the power density achievable for these topologies. Two techniques to deal with hold up time issue are discussed in this dissertation: range winding solution and asymmetric winding solution, the efficiency at normal operation point could be improved with these methods. To reduce secondary rectifier conduction loss, QSW synchronous rectifier is developed, which also helps to achieve ZVS for symmetrical half bridge converter. Although with these methods, the efficiency of front end DC/DC converter could be improved, the excessive switching loss prohibited higher switching frequency. To achieve the targets, topologies with high switching frequency and high efficiency must be developed. Three resonant topologies: SRC, PRC and SPRC, are been investigated for this application because of their fame of low switching loss. Unfortunately, to design with hold up requirement, none of them could provide significant improvements over PWM converter. Although the negative outcome, the desired characteristic for front end application could be derived. Base on the desired characteristic, a thorough search is performed for three elements resonant tanks. LLC resonant topology is found to posses the desired characteristic. From comparison, LLC resonant converter could reduce the total loss by 40% at same switching frequency. With doubled switching frequency, efficiency of LLC resonant converter is still far better than PWM converters. To design the power stage of LLC resonant converter, DC analysis is performed with two methods: simulation and fundamental component simplification. Magnetic design is also discussed. The proposed integrated magnetic structure could achieve smaller volume, higher efficiency and easy manufacture. To make practical use of the topology, over load protection is a critical issue. Three methods to limit the stress under over load situation are discussed. With these methods, the converter could not only survive the over load condition, but also operate for long time under over load condition. Next small signal characteristic of the converter is investigated in order to design the feedback control. For resonant converter, state space average method is no longer valid. Two methods are used to investigate the small signal characteristic of LLC resonant converter: simulation and extended describing function method. Compare with test results, both methods could provide satisfactory results. To achieve both breadth and depth, two methods are both used to reveal the myth. With this information, compensator for feedback control could be designed. Test circuit of LLC resonant converter was developed for front end DC/DC application. With LLC topology, power density of 48W/in3 could be achieved compare with 13W/in3 for PWM converter.
Ph. D.

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15

Clarke, Brandon William. "Development and Optimization of an Integrated Faraday Modulator and Compensator Design for Continuous Polarimetric Glucose Monitoring". University of Toledo / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1364578141.

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16

Sri, Ram Shankar R. "A Probing System for Dynamic Mode Atomic Force Microscopy Based on Specialized Probes". Thesis, 2017. http://etd.iisc.ac.in/handle/2005/4292.

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The dynamic mode atomic force microscope (AFM) is a versatile tool that uses a resonantly excited micro-cantilever probe to obtain a sample’s topography and to characterize its material properties. While a number of useful techniques have been developed for interacting with the sample, conventional AFM probes and AFM systems do not facilitate their effective implementation. This thesis investigates the design of specialized AFM probes and the development of a novel probing system that improves the speed of imaging and enhances the sensitivity to material properties in dynamic mode AFM. In order to perform high speed imaging, an integrated high-bandwidth magnetic actuation system, comprising a special probe and an actuator, is designed and developed. Subsequently, the actuation system is fabricated and evaluated using an in-house developed measurement system to possess an eigen-frequency of 104 kHz and a range of 225 nm. In aqueous medium, the probe is shown to suffer 3 times lesser reduction in eigen-frequency compared to a conventional probe of similar eigen-frequency in air. In order to achieve enhanced sensitivity to material properties, a systematic approach is proposed to design and fabricate probes with specified eigen-frequencies. The proposed approach is employed to design and develop a flexural harmonic probe with eigen-frequencies in the ratio 1:2 and a torsional harmonic probe with eigen-frequencies in the ratio 1:2:3. The experimentally evaluated eigen-frequency ratios are shown to match the specifications to within 0.4% and 2% respectively. Further, harmonic probes with exchangeable tips are proposed and a prototype probe is fabricated and evaluated. The developed harmonic probes are shown to be significantly more sensitive to tip-sample forces. To effectively exploit the high speed and sensitivity of the developed probes, a custom AFM system is designed and developed in-house. The AFM includes a novel Z-magnetic actuation system having bandwidth in excess of 3 MHz and an XY nano-positioning system suitable for video-rate imaging. A novel measurement system based on optical beam deflection is developed and evaluated to measure XY-motion of the positioner. High speed control hardware based on Field Programmable Gate Array (FPGA) has been used for data acquisition and real-time control, with update rates of more than 5 MHz. The developed system is demonstrated to enhance the positioning bandwidth of the high-speed AFM probe, and subsequently employed in high-speed dynamic mode AFM imaging at rates upto 1.25 frames/second. Finally, the potential of the developed system for video-rate dynamic mode AFM imaging, and in-situ material characterization is discussed.

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17

Lin, Kuo Chang, i 林國章. "Implementation and Control of the Magnetic Linear Actuation System". Thesis, 1999. http://ndltd.ncl.edu.tw/handle/60581405252414555761.

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碩士
國立成功大學
航空太空工程學系
87
A passive vibration isolator, which is simple and easy to manipulate, has some shortages such as incapability of dealing with large-amplitude, low-frequency vibration and physical limitations under specific structure. Hence, an active isolator is introduced to overcome the insufficiency of the passive isolators. Several types of active vibration isolators are available for industrial usage, for instance, hydraulic and electromagnetic ones. The objective of this thesis is to construct a magnetic actuation system which can be used to support a platform in which accurate positioning control and vibration isolation are required. To achieve the goal, three tasks are conducted sequentially: (1) hardware implementation, (2) dynamic model development and (3) performance tests. In the system configuration, the actuator drives a permanent magnet by generating magnetic force on it via two current-carrying coils. The exact magnetic force acting on the permanent magnet is obtained by practically measuring the magnetic field inside the actuator instead of applying the idealized formula. The dynamic model is also built up by analyzing the total force acting on the permanent magnet. The feedback control system is constructed by combing the actuator, an eddy current sensor, a PID controller and a PWM type power amplifier. Finally, a series of tests, which includes positioning control and vibration suppression, is conducted to examine the performance of the actuation system.

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Chen, Bo-Wen, i 陳鉑文. "Particles Sorting Utilizing Integrated Optical and Magnetic Tweezers in Micro-channel System". Thesis, 2010. http://ndltd.ncl.edu.tw/handle/76135947622538916881.

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碩士
明志科技大學
機電工程研究所
98
This is a research on classifying magnetic micro-particles in a micro flow tunnel, using an embedded inverted-laser tweezers system, a micro-flow pump and a micro-magnet. Manipulation of the particles in the micro-flow tunnel was achieved. An image recognition system integrated in the micro-flow tunnel was used to identify, count and separate different particles precisely using the laser and magnetic tweezers. In addition, the polystyrene particle classification experiment showed that the good separating result when the continuous flow and magnetic tweezers were used as manipulating forces. The higher the flow velocities were, the larger the separating rate would be, and thus, the largest separating rate was 80% in the study. When the continuous flow and laser tweezers were used as manipulating forces, the polystyrene particle separating rate could be 90%. When the laser tweezers and magnetic tweezers were used, it showed that laser tweezers was the most effective in trapping polystyrene particles when flow velocity were 0.08 to 0.25μm/s. The separating rate of the polystyrene particles could be as high as 95%, and the separating rate of the magnetic particles could also be as high as 85% when the flow rate is around 0.08 to 0.17μm/s.

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Chen, Brian, i 陳柏安. "Design and Development of Integrated Roller Leveling System for Magnetic Encoder Medium Manufacturing". Thesis, 2015. http://ndltd.ncl.edu.tw/handle/15845244988900001077.

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碩士
國立清華大學
動力機械工程學系
103
Magnetic linear encoder has been increasingly integrated in various position control application while demands for high precision machine tool to produce high precision products increase. Due to its advantage in withstanding unclean environment such as oil, grease, and dust over an optical encoder, a magnetic encoder has become a desirable choice for machine tools. During the manufacture of magnetic encoding medium, the medium is not expected to be flat due to packaging induced plastic deformation and residual stress. Medium deformation will result in damaging the performance of the medium such as the accuracy and magnetic flux density distribution. In this paper, the research efforts are devoted to develop a roller leveling system to flatten the curved magnetic medium. Variable roller leveling system is designed and manufactured to perform parameter studies such as number of leveling and the indentation, diameter, and spacing of leveling rollers. Parameter studies are carried out to investigate how roller leveling can be integrated into the manufacture of magnetic encoding medium to improve mechanical deflection and residual stress. Optimal performance of the roller leveling system under specific parameter has been determined. Furthermore, experimental results demonstrate that roller leveling can significantly improve mechanical deflection of pre-stressed curve magnetic medium up to almost 60%. Residual deflection and residual stress of the deformed medium are validated through analytical studies using theory of Euler-Bernoulli beam and Elastica.

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20

Wu, Jia-Han, i 吳佳翰. "An Integrated Paper-Based Microfluidic System for Bacterial Detection Utilizing Magnetic-composite-membrane devices". Thesis, 2017. http://ndltd.ncl.edu.tw/handle/z38d4x.

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Kumar, Kuppa Sampath. "Multiple Fault Parameters Estimation of an Active Magnetic Bearing Integrated Coupled–Rotor–Bearing System". Thesis, 2021. http://ethesis.nitrkl.ac.in/10241/2/2021_PhD_KSKumar_515ID1003_Multiple.pdf.

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Condition monitoring techniques have an important role in continuously running high-speed machines including jet engines, ship propellers, compressors, steam turbines and generators. Early detection and diagnosis of faults such as inherent unbalance, shaft bow/bent, misalignment, bearing, gear, rotor cracks and motor faults associated with these machines are the primary concern of researchers in the field. The excessive vibration generated at higher operating speeds due to these faults can be suppressed and controlled with the help of Active Magnetic Bearings (AMBs). AMB is a mechatronic product used in industries due to its excellent features such as no wear and tear, lubrication-free and frictionless operation due to the absence of mechanical loading. The present work mainly concentrates on the development of an identification algorithm to estimate fault parameters (inherent unbalance and misalignment) along with AMB parameters in an AMB integrated rotor-bearing-coupling system. First, an identification methodology is proposed to quantify fault parameters along with AMB characteristic parameters of a coupled turbine generator system. A simplest possible turbo-generator system is modelled to analyze coupling misalignment and inherent unbalance. Conventional methodology to estimate dynamic system parameters based on forced response information is not enough for an AMB-integrated rotor system because it requires additional current information along with displacement information. The controlling current of AMB is tuned and controlled with the help of a proportional–integral–derivative (PID) type controller. Lagrange’s equation is used to obtain equations of motion (EOMs). Accordingly, a SIMULINKTM model is developed and solved using Runge–Kutta technique to acquire the time domain responses (current and displacement). The fast Fourier transformation (FFT) is applied on obtained responses to acquire responses in frequency domain. A methodology based on the least-squares regression approach is proposed to evaluate the multi-fault parameters of AMB integrated rotor system. The robustness of the algorithm is checked against various levels of noise and modelling error and observed efficient. An appreciable reduction in misalignment forces and moments is observed by using AMBs. Next, a finite element method (FEM) is implemented on the proposed model to overcome the limitations of the numerical model. The purpose of the FEM model is to represent the complex physical system more accurately. A quantification technique is suggested to evaluate the tuned AMB characteristics along with imbalance and coupling misalignment dynamic parameters. A FEM modelling with a high-frequency reduction scheme is utilized to acquire reduced system equations of motion. The advantage of employing a condensation scheme is twofold; first, it reduces the number of sensors required and second, only linear (practically measurable) degrees of freedom present in equations of motion. A SIMULINKTM code is prepared to solve a reduced linear differential equation. The time series signals (current and displacement) obtained are transformed into a frequency series utilizing Fast Fourier Transformation (FFT) and utilized in proposed algorithm. To establish the accuracy and effectiveness of the methodology, the estimated parameters are evaluated under two different frequency bands against measurement noise and modelling error (5% variation in mass of the disc and bearing characteristic parameters). The proposed FEM model is then extended to estimate the speed-dependent fault and AMB characteristic parameters along with speed independent unbalance parameters. Here, a novel gyroscopic high-frequency condensation (GHFC) scheme is proposed to obtain reduced EOMs for the system. The transformation matrix obtained in standard high-frequency condensation (SHFC) is modified by adding a gyroscopic effect into the transformation matrix to achieve the novel GHFC. The estimated parameters are compared for SHFC and GHFC. The GHFC is found effective over SHFC techniques. The effect of noisy response and modelling error on the estimation algorithm is analyzed and found competent. The work carried out in this thesis mainly focuses on the modelling, analysis and estimation of fault parameters of an AMB integrated coupled rotor-bearing system. AMB is used as an agent to suppress the excessive vibration generated due to various faults present in the system. The faults considered in this analysis are coupling misalignment and inherent unbalance. The identification methodology developed has scope in the online condition monitoring of rotating machines.

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Panda, Punyabrahma. "A Microrobotic System with Integrated Force Sensing Capability for Manipulation of Magnetic Particles in Three Dimensions". Thesis, 2019. https://etd.iisc.ac.in/handle/2005/4341.

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Micro-robotic systems are used in various fields of science and technology for the manipulation of objects of size less than a millimeter. Magnetic tweezers can be considered as micro-robotic systems due to their ability to manipulate samples of size in the range of few micrometers. In magnetic tweezers, a magnetic microparticle is manipulated by applying magnetic fields near the particle. Magnetic tweezers are popular for manipulating biological samples due to their high specificity, bio-compatibility and having an untethered end effector that enables them to manipulate inside the samples. Despite these benefits, magnetic tweezers suffer from limitations such as non-linearity in actuation, poor actuation bandwidth, the measurement strategy demanding the particle to be clearly visible and finally, the necessity of sophisticated control strategies for controlling the position of magnetic particles. This thesis investigates the design and development of a micro-robotic system with force sensing capability that addresses the actuation, measurement and control limitations of magnetic tweezers system. In order to address the actuation and measurement limitations of the magnetic tweezers, a current carrying micro-actuator is proposed to apply magnetic forces to the magnetic particles while an integrated force sensor measures the applied force. A simple analytical model for the force of interaction between the micro-actuator and magnetic particle is proposed and employed to show that force is proportional to the actuation current and position of the magnetic particle in three-dimensions (3-D). Further, simple models for mechanical stiffness and rise in temperature due to ohmic heating of the micro-actuator with force sensing capability are proposed. Subsequently, systematic guidelines are proposed for the design of the micro-actuator with force sensing capability. The designed micro-actuator with force sensing capability is fabricated and evaluated. The micro-actuator has an electrical bandwidth of about 1 MHz. The ability of the micro-actuator to apply 3-D forces to a magnetic particle is demonstrated by actuating permanent-magnet microparticles attached to micro-cantilever beams. The force sensing capability of micro-actuator is demonstrated by measuring the deflection of the micro-actuator while it is actuating a permanent-magnet microparticle. The applicability of the micro-actuator with force sensing capability is shown by employing it for the development of a magnetometer to estimate the magnetic moment of micrometer-scale magnetic particles in 3-D. The developed magnetometer is evaluated by measuring magnetic moments of both hard and soft ferromagnetic particles and untethered magnetic particles. The measured magnetic moments agree well with their theoretical counterpart with an average error of 18%. Finally, an open loop control strategy is proposed for controlling the position of magnetic particles in 2-D and 3-D respectively by applying appropriate actuation currents to the micro-actuator. Also, the force sensing capability is utilized to estimate the position of the magnetic particle along the out-of-plane axis of the micro-actuator. The estimated position of the magnetic particle is used to develop a novel scanning probe microscope (SPM) with an untethered probe. The motion of the magnetic particle in 3-D due to actuation current to the micro-actuator is estimated numerically and analyzed by using Mathieu’s equation with Dehmelt’s approximation. The control of the position of magnetic particle is demonstrated by moving the magnetic particles in pre-defined trajectories along 2-D and 3-D respectively. Further, a new strategy is developed to push samples of dimensions much smaller than the size of the magnetic particle. Finally, the imaging capability of the developed SPM is shown by imaging artificially generated topographies using a tethered probe.

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23

Shen, Kao-Mai, i 沈高勱. "An Integrated Microfluidic System for Rapid Detection and Multiple Subtyping of Influenza A Viruses by Using Pentasaccharide-Coated Magnetic Beads and RT-PCR". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/xk5h6r.

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碩士
國立清華大學
動力機械工程學系
106
Influenza A virus (InfA) is one of the global public health threats that causes serious concern in human society every year. Currently, InfA is further classified into many subtypes based on 18 different hemagglutinin (HA) subtypes and 11 different neuraminidase (NA) subtypes. Because of the diversity of viral subtypes, it is difficult to prevent a novel influenza outbreak, especially for cross-species virus transmission. Early diagnosis and accurate subtyping of InfA can help clinical judgment and guide treatment of viral infections and effective flu outbreak management. Moreover, identification of viral subtypes can also offer a lot of valuable information such as origin, infectivity and antiviral resistance of the influenza virus. However, accurate diagnostic methods such as nucleic acid-based approaches are relatively time-consuming and labor-intensive. Furthermore, it requires expensive apparatus and well-trained personnel. Alternatively, rapid influenza diagnostic tests using immunoassays exhibit relatively low sensitivity and specificity and cannot differentiate subtypes of the InfA even though they can be performed in less than 30 minutes. Therefore, there is a crucial need for development of a highly sensitive, highly specific, rapid, easy-to-use and fully automated device for detection and subtyping of influenza viruses. Recently, polysaccharides, which were widely known as targets of viral HA, have been reported as probes to capture influenza viruses. In this work, a new array-type microfluidic chip was therefore developed and integrated into an automatic control system for multiple typing and subtyping of influenza viruses from virus-containing samples by using polysaccharide-coated magnetic beads and one-step reverse-transcription polymerase chain reaction (RT-PCR) processes targeting specific HA and NA. It is the first time that multiple viral subtyping (up to 12 InfA subtypes) could be automated starting from virus pretreatment to optical detection on an integrated microfluidic system. The entire virus detection process was shortened to less than 2 hours which was faster than conventional on-bench RT-PCR method and chip-based microarray systems. Under optimal operating conditions, the limits of detection of the specific primers were experimentally found to be from 2973 to 38 copy numbers for different influenza viruses via on-chip RT-PCR. The results showed significant improvement (around two orders of magnitude) when compared to our previous studies. The subtyping results also demonstrated that this integrated microfluidic system could identify 5 subtypes of InfA and 2 strains of influenza B viruses. In summary, the array-type microfluidic chip system provides a rapid, sensitive, and fully automated approach for the rapid detection and multiple subtyping of InfA.

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Moore, Nina Zobenica. "Meningiomas Assessed with In Vivo 3D 1H-Magnetic Resonance Spectroscopy Integrated Into a Standard Neurosurgical Image Guidance System: Determining Biochemical Markers of Clinically Aggressive Behavior and Providing a Resection Advantage". Thesis, 2011. http://hdl.handle.net/10150/170535.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.
15 usable patients with recurrent or newly diagnosed meningiomas using a 3T GE Signa scanner. Quantified spectral metabolite peaks were used to select voxels that had high or low alanine for tissue sampling. 3D 1H-MRSI was integrated into a standard image guided surgery (IGS) system; a mask of the voxel was loaded onto the IGS system allowing surgeons to precisely extract tissue intraoperatively according to biochemical mapping. Ex vivo NMR and conventional histological grading were performed on the extracted tissue. Results: Tumor spectra showed biochemically heterogeneous regions, especially for choline, lactate and alanine. Mean alanine concentrations were lower in more aggressive--histologically and immunohistochemically--regions of the meningiomas in the study. In addition, lower grade meningiomas showed high alanine at the tumor periphery with decreased central alanine. Ex vivo NMR was well-correlated with in vivo 3D 1H-MRSI. Conclusions: Non-invasive detection of various intratumoral biochemical markers using 3D 1H-MRSI can distinguish areas within meningiomas that express more aggressive features. There is regional heterogeneity in the concentrations of these markers within individual tumors. Furthermore, 3D 1H-MRSI may be able to exploit these regional differences to separate more aggressive from less aggressive areas within a given meningioma. Such knowledge may be useful to 5 the neurosurgeon faced with the task of meningioma resection, and in the planning adjuvant therapy for residual meningioma

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LIN, YU-JEN, i 林俞任. "Investigation on Equivalent Circuit Analysis of Large-area Arrayed TiO2/ZnO Dye-sensitized Solar Cell Modified by Graphene Integrated with Magnetic Beads and Study on Wireless-based Remote Real-time Monitoring System". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/rsa2ju.

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26

Alibakhshikenari, M., B. S. Virdee, C. H. See, Raed A. Abd-Alhameed, F. Falcone i E. Limiti. "High-gain metasurface in polyimide on-chip antenna based on CRLH-TL for sub-terahertz integrated circuits". 2020. http://hdl.handle.net/10454/17985.

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Yes
This paper presents a novel on-chip antenna using standard CMOS-technology based on metasurface implemented on two-layers polyimide substrates with a thickness of 500 μm. The aluminium ground-plane with thickness of 3 μm is sandwiched between the two-layers. Concentric dielectric-rings are etched in the ground-plane under the radiation patches implemented on the top-layer. The radiation patches comprise concentric metal-rings that are arranged in a 3 × 3 matrix. The antennas are excited by coupling electromagnetic energy through the gaps of the concentric dielectric-rings in the ground-plane using a microstrip feedline created on the bottom polyimide-layer. The open-ended feedline is split in three-branches that are aligned under the radiation elements to couple the maximum energy. In this structure, the concentric metal-rings essentially act as series left-handed capacitances CL that extend the effective aperture area of the antenna without affecting its dimensions, and the concentric dielectric rings etched in the ground-plane act as shunt left-handed inductors LL, which suppress the surface-waves and reduce the substrates losses that leads to improved bandwidth and radiation properties. The overall structure behaves like a metasurface that is shown to exhibit a very large bandwidth of 0.350–0.385 THz with an average radiation gain and efficiency of 8.15dBi and 65.71%, respectively. It has dimensions of 6 × 6 × 1 mm3 that makes it suitable for on-chip implementation.
This work is partially supported by RTI2018-095499-B-C31, Funded by Ministerio de Ciencia, Innovación y Universidades, Gobierno de España (MCIU/AEI/FEDER,UE), and innovation programme under grant agreement H2020-MSCA-ITN-2016 SECRET-722424 and the fnancial support from the UK Engineering and Physical Sciences Research Council (EPSRC) under grant EP/E022936/1.
Research Development Fund Publication Prize Award winner, March 2020

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WU, CIAN-YI, i 吳芊嬑. "Investigation on Sensing Characteristics and Stability of Arrayed Flexible Glucose and Urea Biosensor Based on TiO2 and NiO Films Modified by Magnetic Beads and Graphene Oxide, and Integrated with Microfluidic Framework and Real-Time Sensing System". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/3v4kj4.

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碩士
國立雲林科技大學
電子工程系
106
In this thesis, two kinds of metal oxide were proposed as martrix for flexible arrayed urea biosensor. The metal oxide films were Nickel Oxide (NiO) and Titanium dioxide (TiO2), respectively. The radio frequency sputtering system deposits the sensing film, and the screen printing technology were used to prepare the conductive arrayed wires and the reference electrode, and the epoxy is to encapsulate flexible arrayed urea biosensor. However, the covalent binding method is used to immobilize the enzyme between the matrix of the urea biosensor, and the preparation of the urea biosensors were completed. Afterwards, the sensing films of nickel oxide and titanium dioxide were modified by using graphene oxide and magnetic beads to improve its properties. The basically sensing properties of the two kinds of matrix biosensors were measured, and response time, interference and detection limit were also measured. However, the urea biosenosrs were integrated into the microfluidic measurement system and wireless real-time sensing system to measure the sensing properties of the urea biosensor under dynamic conditions, and it achieved remote monitoring. In addition, the feasibility of TiO2 matrix for the development of glucose sensors were discussed. Finally, we compared the literatures with the urea biosensors and glucose sensor in this thesis.

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Wu, You-Xiang, i 吳友祥. "The Research of Differential Reference Electrode Integrated with Magnetic Beads and Graphene Oxide Modified Arrayed Flexible IGZO/Al Ascorbic Acid Biosensor Based on Microfluidic Framework as well as Measurements for Sensing Characteristics, Equivalent Circuit and Real-time Sensing System". Thesis, 2018. http://ndltd.ncl.edu.tw/handle/ktdemv.

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碩士
國立雲林科技大學
電子工程系
106
In this thesis, the screen-printed technology, radio frequency sputtering system and thermal evaporation system were used to integrate indium gallium zinc oxide (IGZO) membrane, Al electrode and silver paste onto the PET (polyethylene terephthalate) substrate. Next, the covalent bonding was used to immobilize ascorbate oxidase (AOX) onto the IGZO sensing membrane, and the flexible arrayed enzymatic L-ascorbic acid (L-AA) biosensor was completed. Besides, the graphene oxide (GO) and magnetic beads (MBs) were used to modify IGZO sensing membrane, and the electrochemical impedance spectroscopy (EIS) was used to confirm whether the GO and MBs were modified onto the sensing membrane successfully. According to the experimental results, the average sensitivity and linearity of MBs-AOX/GO/IGZO/Al L-AA biosensor were 78.9 mV/decade and 0.997, respectively. In this thesis, the response time, drift effect, hysteresis effect, anti-interfering effect and life time were investigated. Moreover, the sensing characteristic of L-AA biosensor which was integrated with microfluidic framework was detected under the different flow rates. Finally, in order to achieve remote monitoring, the L-AA biosensor was integrated with wireless real-time sensing system based on XBee module.

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(11191896), Chamika M. Liyanagedera. "Intelligent Sensing and Energy Efficient Neuromorphic Computing using Magneto-Resistive Devices". Thesis, 2021.

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With the Moore’s Law era coming to an end, much attention has been given to novel nanoelectronic devices as a key driving force behind technological innovation. Utilizing the inherent device physics of nanoelectronic components, for sensory and computational tasks have proven to be useful in reducing the area and energy requirements of the underlying hardware fabrics. In this work we demonstrate how the intrinsic noise present in nano magnetic devices can pave the pathway for energy efficient neuromorphic hardware. Furthermore, we illustrate how the unique magnetic properties of such devices can be leveraged for accurate estimation of environmental magnetic fields. We focus on spintronic technologies in particular, due to the low current and energy requirements in contrast to traditional CMOS technologies.

Image segmentation is a crucial pre-processing stage used in many object identification tasks that involves simplifying the representation of an image so it can be conveniently analyzed in the later stages of a problem. This is achieved through partitioning a complicated image into specific groups based on color, intensity or texture of the pixels of that image. Locally Excitatory Globally Inhibitory Oscillator Network or LEGION is one such segmentation algorithm, where synchronization and desynchronization between coupled oscillators are used for segmenting an image. In this work we present an energy efficient and scalable hardware implementation of LEGION using stochastic Magnetic Tunnel Junctions that leverage the fast parallel

nature of the algorithm. We demonstrate that the proposed hardware is capable of segmenting binary and gray-scale images with multiple objects more efficiently than
existing hardware implementations.

It is understood that the underlying device physics of spin devices can be used for emulating the functionality of a spiking neuron. Stochastic spiking neural networks based on nanoelectronic spin devices can be a possible pathway of achieving brain-like compact and energy-efficient cognitive intelligence. Current computational models attempt to exploit the intrinsic device stochasticity of nanoelectronic synaptic or neural components to perform learning and inference. However, there has been limited analysis on the scaling effect of stochastic spin devices and its impact on the operation of such stochastic networks at the system level. Our work attempts to explore the design space and analyze the performance of nanomagnet based stochastic neuromorphic computing architectures, for magnets with different barrier heights. We illustrate how the underlying network architecture must be modified to account for the random telegraphic switching behavior displayed by magnets as they are scaled into the superparamagnetic regime.

Next we investigate how the magnetic properties of spin devices can be utilized for real world sensory applications. Magnetic Tunnel Junctions can efficiently translate variations in external magnetic fields into variations in electrical resistance. We couple this property of Magnetic Tunnel Junctions with Amperes law to design a non-invasive sensor to measure the current flowing through a wire. We demonstrate how undesirable effects of thermal noise and process variations can be suppressed through novel analog and digital signal conditioning techniques to obtain reliable and accurate current measurements. Our results substantiate that the proposed noninvasive current sensor surpass other state-of-the-art technologies in terms of noise and accuracy.

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