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Rozprawy doktorskie na temat „Immunolog”

Autor: Grafiati

Data publikacji: 29 lipca 2024

Data aktualizacji: 31 lipca 2025

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1

Tjärnlund, Anna. "Mucosal Immunity in Mycobacterial infections." Doctoral thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6782.

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<p>More than a century after the identification of the tubercle bacillus and the first attempts at vaccination, tuberculosis (TB) still remains one of the world’s most serious infectious diseases. TB, caused by the bacterium <i>Mycobacterium tuberculosis</i>, is typically a disease of the lung, which serves both as port of entry and as the major site of disease manifestation. The currently used vaccine, BCG, is administered parenterally and induces a systemic immune response. However, it fails to protect against pulmonary TB, thereby raising the question whether vaccination targeting the mucos

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2

Vafa, Manijeh. "Human genetic factors in relation to Plasmodium falciparum infection." Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7136.

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3

Israelsson, Elisabeth. "The role of antibody mediated parasite neutralization in protective immunity against malaria." Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7137.

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4

Sjögren, Ylva. "Early infant gut flora and neutral oligosaccharides in colostrum in relation to allergy development in children." Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7152.

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<p>Today, atopic allergy is the most common chronic disease among children in the developed world. The increase in allergy prevalence during the past decades in these countries might be associated with lower microbial exposure. The gut flora, consisting of approximately 800 different species of bacteria, has been postulated to be important for the development of a fully functional immune system. Essentially, these bacteria are in constant contact with the gut flora associated lymphoid tissue, the largest lymphoid tissue of the human body. Following birth, the sterile gut of the newborn is imme

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5

Ali, Magdi Mahmoud. "Immunologic aspects of the pathogenesis of human onchocerciasis." Doctoral thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-793.

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<p>Onchocerciasis, or river blindness, is a parasitic disease that affects more than 20 million people globally. The induction of pathology is directly related to the presence and destruction of the microfilarial stages (mf) of this filarial nematode. The disease presents clinically with a wide spectrum of dermal and ocular manifestations, the basis of the variation is believed to involve the immune system. The clinical presentations of infected hosts relate to the intensity of the reactions against the parasite. Anti-microfilarial drugs are also thought to somehow involve the immune system in

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6

Rahman, Muhammad Jubayer. "Diagnostic biomarkers and improved vaccination against mycobacterial infection." Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8238.

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<p>Tuberculosis (TB) remains one of the world’s most serious infectious diseases. It is estimated that a third of the world’s population is latently infected and 8 million new cases are recorded each year. Although BCG vaccination triggers protective immune responses in the neonates, it confers protection against only certain forms of childhood TB. Protection mediated by BCG, against pulmonary TB, is controversial as reported with variable efficacy ranging from 0-80%. In addition to the problems associated with the BCG vaccine, diagnosis of TB cannot be performed readily with the available too

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7

Sundström, Yvonne. "Phenotypic and functional studies of NK cells in neonates and during early childhood." Doctoral thesis, Stockholms universitet, Wenner-Grens institut för experimentell biologi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8258.

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During infancy, before adaptive immunity has matured, innate immunity is thought to be relatively more important. Human natural killer (NK) cells are innate immune cells involved in the control of virus-infected cells and can influence adaptive immunity mainly through cytokine production. This thesis aimed at investigating function and phenotype of NK cells in children from birth and during early childhood and to see if these features are altered in children that develop early allergy, in children latently infected by herpes viruses or born by preeclamptic mothers. Our results suggest that NK-

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8

Walldén, (Fredriksson) Jenny. "Studies of immunological risk factors in type 1 diabetes." Doctoral thesis, Linköpings universitet, Pediatrik, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-12441.

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Background: Type 1 diabetes (T1D) is a chronic, autoimmune disease caused by a T cell mediated destruction of ß-cells in pancreas. The development of T1D is determined by a combination of genetic susceptibility genes and environmental factors involved in the pathogenesis of T1D. This thesis aimed to investigate diverse environmental and immunological risk factors associated with the development of T1D. This was accomplished by comparing autoantibody development, T cell responses and the function of CD4+CD25+ regulatory T cells between healthy children, children at risk of T1D and T1D patients.

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9

Amoudruz, Petra. "Maternal immune characteristics and innate immune responses in the child in relation to allergic disease." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7818.

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The mechanistic factors responsible for the increase in allergic diseases are still not fully understood, but a reduced microbial stimulation seems to be one of the key issues. Research is now aiming at investigating the relationship between the innate immune system, involving the toll-like receptors, and allergy development. Further, the maternal influence on the child, possibly through in utero effects, but also through the breast milk, has shown to be of great importance. This thesis aimed at understanding how the maternal immune system is influenced by early exposures and allergic disease,

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10

Sohlberg, Ebba. "Innate immune responses in cord blood,and the influence of pathological pregnancy." Licentiate thesis, Stockholms universitet, Avdelningen för immunologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-54575.

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11

Balogun, Halima Aramide. "Immunological characteristics of a C-terminal fragment of the Plasmodium falciparum blood-stage antigen Pf332." Licentiate thesis, Stockholms universitet, Wenner-Grens institut, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7143.

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Till date, there are no effective control strategies against the deadly disease of malaria, and millions of children across Africa, Oceania, Asia, and Latin America are at the mercy of this long term enemy of man every second that passes by. Other control measures combined with vaccination might help improve control strategy against malaria, but the development of vaccines face various challenges as well, due to the complexity of the parasites’ life cycle and other host factors. The asexual blood stage antigen Pf332 of Plasmodium falciparum, is expressed during the trophozoite stage, and trans

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12

Awah, Nancy. "Malarial anaemia : the potential involvement of Plasmodium falciparum rhoptry proteins." Licentiate thesis, Stockholms universitet, Wenner-Grens institut, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8460.

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Malaria remains a challenging health problem in malaria endemic regions. Infection with malaria invariably leads to anaemia. The groups at risk of developing malarial anaemia include children below the age of five years and pregnant women, especially primigravidae. Several factors have been suggested to be responsible for its aetiology, including increased destruction of infected and normal red blood cells together with bone marrow suppression. However, until recently, the molecular mechanisms involved have remained elusive. The aim of the work presented herein was to investigate the mechanism

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13

Mangano, Valentina D. "Dissecting the complexity of human susceptibility to Plasmodium falciparum malaria : genetic approaches /." Doctoral thesis, Stockholm : Wenner-Gren Institute for Experimental Biology, Stockholm University, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8310.

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14

Tjärnlund, Anna. "Does IgA play a role in protection against pulmonary tuberculosis?" Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-552.

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<p>More than a century after the identification of the tubercle bacillus and the first attempts at vaccination, tuberculosis (TB) still remains one of the world’s most serious infectious diseases. TB is typically a disease of the lung, which serves both as port of entry and as the major site of disease manifestation. The currently used vaccine, <i>Mycobacterium bovis</i> bacillus Calmette-Guérin (BCG), is administered parentally and induces a systemic immune response. However, it fails to protect against pulmonary TB, thereby raising the question whether vaccination targeting the mucosal immun

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15

Arko-Mensah, John. "Immune evasion and identification of biomarkers associated with mycobacterial infection." Licentiate thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-7253.

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16

Johansson, Alina. "Molecular mechanisms behind TRIM28expression." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-252834.

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17

Andersson, Jonas. "Complement Activation Triggered by Biomaterial Surfaces : Mechanisms and Regulation." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis Univ.-bibl. [distributör], 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-3410.

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18

Mouchtaridi, Elli. "The role of exosomes in sarcoidosis." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-446010.

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Sarcoidosis is a systemic inflammatory disease mostly affecting the lungs, marked by the presence of granulomas and the accumulation of interferon gamma (IFNγ)-producing T cells in the affected organs. Extracellular vesicles (EVs) are membranous vesicles with a size range of 50 nm to 5000 nm, with exosomes ranging from 50 to 150 nm. They are major players in intercellular communication and have been found in all body fluids including plasma. In this study, we wanted to characterize the exosomes from sarcoidosis patients’ plasma and try to detect differences in their surface marker expression.

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19

Mullazehi, Mohammed. "Anti-Collagen Type II Autoantibodies in an Acute Phenotype of Early Rheumatoid Arthritis." Doctoral thesis, Uppsala universitet, Institutionen för onkologi, radiologi och klinisk immunologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100483.

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Rheumatoid arthritis (RA) is an autoimmune disease with systemic inflammatory features that primarily affects small peripheral joints. Type II collagen (CII), is the most abundant collagen type in joint cartilage. Antibodies against CII (anti-CII) are found in a subpopulation of RA patients. Anti-CII can form surface-bound immune complexes (IC) in inflamed joints, which might intensify joint inflammation and destruction. In this thesis I have studied the functional effects of surface-bound anti-CII–containing IC in vitro and correlated the results to clinical parameters. Anti-CII IC induced TN

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20

Åhlin, Erik. "Functional Role of Immune Complexes in Rheumatic and Parasitic Diseases." Doctoral thesis, Uppsala universitet, Klinisk immunologi, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-139529.

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Immune complexes (IC) have key pathological roles in both autoimmune and infectious diseases. In this thesis functional mechanisms behind IC-driven inflammation in rheumatic diseases and tropical infections have been studied, with special focus on the contribution of autoantibodies and cytokine-inducing properties of IC. In the autoimmune disease SLE, increased levels of IC-induced cytokines were associated with both increased classical complement activation and the occurrence of the autoantibodies anti-SSA and anti-SSB, both directed against RNA-associated antigens. In addition, complement ac

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21

Andersson, Josefin. "Utvärdering av Malaria Antigen ELISA kit för diagnostik av malaria vid Christian Medical College and Hospital i Vellore, Indien. : en jämförande studie mellan Quantitative buffy coat och enzyme-linked immunosorbent assays (ELISA) metodik." Thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-4889.

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Malaria är ett globalt hälsoproblem som orsakar många dödsfall runt om i världen varje år och nästan hälften av jordens befolkning ligger i riskzonen att drabbas av sjukdomen. I Indien drabbas mellan 2-3 miljoner människor varje år och det inträffar omkring 900 dödsfall. Malaria orsakas av Plasmodium sp. som är en protozoe, och det finns fyra olika arter som är patogena för människor, P. vivax, P. ovale, P. falciparium samt P. malariae. Vanliga metoder för att diagnostisera malaria är genom tunna och tjocka blodutstryk som färgas till exempel med Giemsa, Fields eller Leishmans färgningsteknik

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22

Martin, Melina Toni Marie. "The effects of probiotic and dietary fiber administration on intestinal physiological markers in pigs." Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-416249.

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23

Kajbaf, Mohammad Javad. "Immunology of trachoma." Thesis, University of Southampton, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.236213.

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24

Veenstra, van Nieuwenhoven Angélique L. "Immunology of pregnancy." [S.l. : [Groningen : s.n.] ; University of Groningen] [Host], 2009. http://irs.ub.rug.nl/ppn/.

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25

Andrén, Maria. "The Role of Fc Gamma Receptors in Experimental Arthritis." Doctoral thesis, Uppsala University, Department of Genetics and Pathology, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-4724.

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<p>Induction of collagen-induced arthritis (CIA), an animal model for human rheumatoid arthritis, is dependent on anti-collagen type II (CII) antibodies. The effector mechanism by which autoantibodies contribute to inflammatory reactions in autoimmune diseases is not well understood. In this thesis I have studied the effector pathways used by IgG anti-CII antibodies to initiate arthritis, namely the IgG Fc receptors (FcγRs) and the complement system. We have found that FcγRIII is crucial for development of CIA, as CII-immunized mice lacking this receptor do not develop arthritis and IgG1 and I

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26

Li, ShuShun. "Thrombospondin 1, an autocrine regulator in T cell adhesion and migration." Doctoral thesis, Umeå : Klinisk mikrobiologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-599.

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27

Douguet, Laetitia. "Conséquences de l’expression de la synthétase de l’oxyde nitrique de type 2 (NOS2) sur les fonctions des lymphocytes T γδ au cours du développement du mélanome". Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015USPCB106/document.

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Au cours du développement d’un cancer, la tumeur se forme dans un environnement adapté à sa croissance appelé microenvironnement tumoral. Celui-ci est constitué d’un réseau complexe qui orchestre la progression tumorale et dans lequel sont présents différents types cellulaires, des facteurs solubles ainsi que des composants de la matrice extracellulaire. Parmi les cellules du microenvironnement tumoral, on trouve les cellules du système immunitaire. Certaines ont la capacité de reconnaître et d’éliminer directement les cellules cancéreuses, tandis que d’autres promeuvent la croissance tumorale

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28

Bachmayer, Nora. "The role of natural killer cells and inflammatory mediators in preeclamptic pregnancies." Doctoral thesis, Stockholm University, Wenner-Gren Institute for Experimental Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-8220.

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<p>The maternal immune system must be able to adjust during pregnancy and accept the foetus that expresses paternal antigens. These changes are found both in placenta and circulation, including a mild inflammatory response. NK cells are abundant during the early part of pregnancy in placenta and are thought to be important for placental development. During preeclampsia the placenta is poorly developed, together with an escalated pro-inflammatory profile noticed in both placenta and circulation. We wanted to study NK cells in placenta and circulation from preeclamptic cases as well as levels of

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29

Šilanskas, Mantas. "Oncolytic viruses armed with immunostimulatory genes for cancer treatment." Thesis, Uppsala universitet, Institutionen för immunologi, genetik och patologi, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-353153.

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Cancer is a major health burden in modern society, costing millions of lives worldwide and negatively impacting many more. With increasing rates of cancer, there is a need for new approaches to its treatment. This is where immunotherapies step in, this a relatively new approach to cancer treatment which caught public’s attention only in recent years. The main goal of these therapies is to enhance and help immune cells to identify and kill tumor cells, thereby initiating the cycle of cancer immunity. In this project LOAd platform viruses were evaluated and compared for their ability to induce o

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30

Hutchings, Nicholas James. "Proteome analysis in immunology." Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.393404.

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31

Venkatesan, Pradhib. "Immunology of murine giardiasis." Thesis, Nottingham Trent University, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281702.

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32

Humphreys, Kenneth Andrew. "Intestinal immunology in man." Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/22330.

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Loss of IgG to the gut in patients with inflammatory bowel disease (IBD) can arise from plasma or by local production from cells in the lamina propria. The source of IgG in WGLF was shown to be predominantly plasma since the relative coefficient of excretion for IgG in WGLF was similar to albumin for all colonic IBD patients with a range of disease activity. As albumin is much mores susceptible to proteolysis than are immunoglobulins, the study was restricted to patients with colonic disease and without extremes of WGLF protease activity. It has been assumed that protein loss occurs from the s

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33

Bui, Naomi Nhu. "Immunology of Tumamoc Hill." Thesis, The University of Arizona, 2014. http://hdl.handle.net/10150/319939.

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34

Lindroth, Karin. "Maturation of humoral immune responses : Studies on the effects of antigen type, apoptosis and age." Doctoral thesis, Stockholm : Wenner-Grens institut, Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-85.

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35

Charbit-Henrion, Fabienne. "Characterization of monogenic enteropathies." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB059/document.

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Pas de résumé<br>Background: Mendelian mutations causing monogenic enteropathies are identified in an increasing number of genes and are responsible for either chronic inflammatory diseases (frequently called VEO-IBD for very early-onset inflammatory bowel diseases) or for congenital diarrheal disorders (CDD). Management of many patients with monogenic enteropathies requires difficult therapeutic decisions and heavy treatments, such as hematopoietic stem cell transplantation for VEO-IBD patients, or total parenteral nutrition and intestinal transplantation for CDD patients. Early molecular dia

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36

Norgren, Niklas. "Neurofilament light as a marker for neurodegenerative diseases." Doctoral thesis, Umeå : Univ, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-357.

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37

Delpoux, Arnaud. "Rôle de l’autoréactivité sur les capacités suppressives des lymphocytes T régulateurs CD4+ Foxp3+." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T052/document.

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La plupart des lymphocytes T régulateurs CD4+ Foxp3+ (Tregs) sont générés dans le thymus. Plusieurs études suggèrent fortement que le développement des Tregs est dû à la forte affinité de leur TCR pour le soi (complexes « peptide du soi-CMH II ») présenté dans le thymus. Après avoir migré à la périphérie, les Tregs continuent d’interagir avec le soi et l’expression de Foxp3 est considérée comme nécessaire et suffisante pour maintenir le programme de transcription nécessaire aux fonctions suppressives de ces cellules en périphérie. En utilisant deux models expérimentaux chez la souris, notre ét

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38

Kroca, Michal. "Expansion of circulatory Vγ9Vδ2 T cells in tularemia and Pontiac fever, two intracellular bacterial diseases with widely different clinical expression". Doctoral thesis, Umeå University, Clinical Microbiology, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-84.

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<p>Although well established that human Vγ9Vδ2 T cells may expand in circulation during intracellular bacterial infections, most underlying studies included only a few cases and only some diseases had been studied so far. In tularemia, a severe invasive disease, only one patient had been described. Legionellosis, including the mild flue-like Pontiac disease caused by Legionella micdadei, had not been studied at all. The aim of the present thesis was to study the circulatory Vγ9Vδ2-T cell response in these two intracellular bacterial diseases. The number of cases included was large enough to dr

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39

Baey, Camille. "Etude de l’efficacité et des mécanismes de la présentation croisée d’antigènes cellulaires tumoraux intacts par les cellules dendritiques." Thesis, Paris 5, 2013. http://www.theses.fr/2013PA05T054/document.

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Les cellules dendritiques (DC) sont spécialisées dans la capture, l’apprêtement et la présentation des antigènes. Elles ont développé une voie spécifique de présentation, la présentation croisée, leur permettant d’internaliser des antigènes exogènes, de les digérer et de les associer aux molécules du CMH de classe I afin de les présenter aux lymphocytes T CD8+. La présentation croisée est essentielle à la présentation d’antigènes qui ne sont pas synthétisés directement dans les DC (antigènes du soi, de tumeurs, de microorganismes n’infectant pas les DC) et donc à l’établissement de réponses T

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40

Becht, Etienne. "Transcriptomic analysis of the immune microenvironment of non-hematopoietic human tumors." Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05T029/document.

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Le microenvironnement des tumeurs est composé de cellules immunitaires, de fibroblastes et de cellules endothéliales, ainsi que d’autres cellules non-malignes. Son étude a permis d’établir des classifications qui ont une valeur pronostique et théranostique, ainsi que de développer des traitements modulant la composition et l’orientation fonctionnelle du microenvironnement. En parallèle, des classifications moléculaires des tumeurs ont proposé des taxonomies stratifiant les cancers humains en sous-groupes associés à des différences de survie des patients et leur réponse aux traitements. Des étu

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41

Awah, Nancy. "Studies on Plasmodium falciparum asexual blood stage antigens : RAP-2/RSP-2 and Pf332 in focus." Doctoral thesis, Stockholms universitet, Wenner-Grens institut, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-57255.

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The life cycle of the malaria parasite is very complex and provides a number of potential targets for vaccination. In this thesis, data on two plasmodial asexual blood stage antigens (RAP-2 and Pf332) are presented. A partial aim of the work presented herein was to investigate the mechanisms responsible for the destruction of erythroid cells in anaemia, and more specifically to define the role of the rhoptry associated protein (RAP)-2 and other members of the RAP complex, RAP-1 and -3 in processes resulting in anaemia. Antibodies to the RAP complex were shown to have the potential to mediate t

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42

Malm, Christer. "Immunological changes in human blood and skeletal muscle in response to physical exercise /." Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-7349-035-0/.

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43

Newsom-Davis, Thomas Edmund. "Fas Ligand and Tumour Immunology." Thesis, Imperial College London, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486884.

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Fas ligand (FasL) is a transmembrane protein which induces apoptosis in cells expressing its receptor, Fas. The FasL/Fas pathway is one ofthe major mediators of cell death in the immune system but more recently an inflammatory role has been suggested. This thesis investigated the finding that when injected into mice, FasL-expressing (FasL+) tumours recruit a massive polymorphonuclear neutrophil (PMN) infiltration and are then rejected, which is followed by the development of antibody mediated tumour immunity. . In this work, eight IgM and one IgG2a monoclonal antibodies (mAbs) were produced fr

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Howes, Moira Ann. "Immunology and the indiscrete self." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0008/NQ42530.pdf.

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Sheu, Eric G. "Immunology of T cell vaccines." Thesis, University of Oxford, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.288552.

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Figueredo, Grazziela P. "Translating simulation approaches for immunology." Thesis, University of Nottingham, 2012. http://eprints.nottingham.ac.uk/12905/.

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This thesis presents a novel set of guidelines to convert between simulation modelling approaches, namely, Ordinary differential Equations (ODEs), System Dynamics (SD) and Agent-based Modelling and Simulation (ABMS). In our literature review we identify a gap in establishing translation techniques between these approaches. We therefore focus our research in developing these techniques and assessing the impact of these conversions in the simulation outcomes. In particular, our interest lies in investigating our techniques applied to simulation problems for the immune system, as we wish to aid i

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Zhao, Yuan. "Immunology of granulomatosis with polyangiitis." Thesis, King's College London (University of London), 2013. https://kclpure.kcl.ac.uk/portal/en/theses/immunology-of-granulomatosis-with-polyangiitis(91230752-735f-41ea-8695-f26f8b2e5c97).html.

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Granulomatosis with polyangiitis (GPA, formerly known as Wegener’s granulomatosis) is a rare and sometimes fatal systemic autoimmune disease. Anti-neutrophil cytoplasmic antibodies (ANCAs) specific for proteinase 3 (PR3) are associated with GPA. However, the pathogenesis of GPA is not yet clear. Our aim was to investigate the local autoimmune response, circulating immune modulatory cells and cells expressing the immune suppressor molecules programmed death 1 (PD-1) and its ligands in GPA. In mucosa from GPA patients, activated B cells were observed located alongside PR3 expressing cells and B

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Thompson, Fiona Mary. "Malaria immunology and vaccine development." Thesis, University of Southampton, 2008. https://eprints.soton.ac.uk/67626/.

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This thesis describes work undertaken by the author at the University of Oxford. It begins by providing an introduction to malaria infection and pathophysiology, and a review of the latest attempts to produce an effective malaria vaccine. It goes on to describe the rationale behind the vaccines developed by the University of Oxford and others. A brief introduction to the process of planning and carrying out clinical trials of vaccines is then provided, and is followed by chapters describing two clinical trials, designed to test the safety, immunogenicity and then efficacy of candidate malaria

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Farouk, Salah Eldin. "T cell and antibody responses in Plasmodium falciparum malaria and their relation to disease susceptibility." Doctoral thesis, Stockholm : Wenner-Grens institut för experimentell biologi, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-320.

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Cerboni, Silvia. "Identification of the activities of the antiviral innate immune sensor STING in CD4+ T lymphocytes." Thesis, Sorbonne Paris Cité, 2016. http://www.theses.fr/2016USPCB091/document.

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Le corps humain est quotidiennement exposé à de nombreux micro-organismes et le système immunitaire est responsable du maintien de son intégrité. Suite à une infection, le système immunitaire inné déclenche une réponse rapide, non spécifique à l’agent pathogène, et amorce le système immunitaire adaptatif qui lui permet de contenir et d’éliminer spécifiquement le pathogène. Tous les virus et de nombreuses bactéries entrent dans le cytosol des cellules hôtes et commencent à se répliquer. Bien que les acides nucléiques possèdent une structure universelle, l’ADN du soi est présent dans les noyaux

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