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Vauleon, Elodie. "Implications des gènes immuns et des cellules immunes dans le glioblastome". Thesis, Rennes 1, 2013. http://www.theses.fr/2013REN1B005/document.
Pełny tekst źródłaBackground: Glioblastoma is the most common and lethal primary brain tumor in adults. Epidemiological studies have revealed that a history of allergies is a protective factor, thereby underlining the likely impact of the immune system on GBM. A number of transcriptomic studies have also identified immune signatures more or less associated with patient survival. Methods: In order to clarify and identify which immune-associated (IA) genes were the most involved in GBM, we studied the expression of 791 immune genes in GBM and normal brains samples. Interactions between IA genes were studied through an analysis of co-expression network. We then searched for a link between IA genes and patient survival according to 3 statistical methods, before defining a mathematical risk model based on different data sets. Finally, we studied the infiltrative immune population of 73 GBM by cytometry. Results: A significantly different profile of IA genes expression between healthy brains and GBM was consistently defined, but not among GBM. The analysis of co-expression network revealed 6 modules, 5 of which were enriched by genes associated with patient survival. 108 IA genes have a significant association with patient survival and the 6-IA gene risk predictor allowed us to distinguish two groups of patients according to their survival, including patients whose tumor had a methylated MGMT gene promoter and in the subset of proneural GBM. Finally, in every analyzed GBM sample, we have shown that there was a leukocyte infiltration by macrophages/microglial cells and sometimes by lymphocytes or granulocytes. Only the lymphocytes infiltration was significantly associated with the survival in our group of patients. Conclusion: IA genes that are involved in various immune functions are expressed differentially between healthy brains and GBM and amongst GBM. A robust 6-IA gene risk predictor was defined: it divides patients into two low and high risk groups, including those who have a good prognosis. Finally, we revealed an infiltration of immune cells in a series of GBM, only the lymphocytic infiltration was positively associated with patient survival
Nerurkar, Louis. "Neuro-immune responses to distal immune stimulus". Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/8529/.
Pełny tekst źródłaJohansson, Susanne. "Compartmentmentalized immuno-sequencing (cI-Seq) : identification of immune complex interactions". Thesis, KTH, Genteknologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-196872.
Pełny tekst źródłaProtheroe, Rachel Elizabeth. "Investigation of immune regulation in human alloreactive immune responses". Thesis, University of Bristol, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.520287.
Pełny tekst źródłaRosa, Gustavo Luis Teixeira Lopes. "Studies of MHV-68 immune evasion and immune control". Thesis, University of Cambridge, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.611892.
Pełny tekst źródłaMcIntosh, Alistair James. "The role of adipose tissue immune cells in immune responses". Thesis, University of Birmingham, 2018. http://etheses.bham.ac.uk//id/eprint/8113/.
Pełny tekst źródłaSINGH, REETIKA. "COMPARATIVE ANALYSIS OF DIFFERENT CURCUMIN ANALOGUES TO INHIBIT TLR4 EXPRESSION IN BREAST CANCER- AN IN-SILICO STUDY". Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18459.
Pełny tekst źródłaWassall, Heather Jane Haining. "Dietary influences and immune regulation of neonatal immune responses to allergens". Thesis, University of Aberdeen, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.485812.
Pełny tekst źródłaMacaulay, R. "The role of immune inhibitory receptors in age-associated immune decline". Thesis, University College London (University of London), 2011. http://discovery.ucl.ac.uk/1317772/.
Pełny tekst źródłaDehus, Oliver. "Receptor polymorphisms and non-classical immune stimuli in bacterial immune recognition". [S.l. : s.n.], 2008. http://nbn-resolving.de/urn:nbn:de:bsz:352-opus-61639.
Pełny tekst źródłaMsallam, Rasha. "Intravital imaging and immuno-regulatory functions of mast cells in cutaneous immune responses". Thesis, Sorbonne Paris Cité, 2015. http://www.theses.fr/2015PA05T019.
Pełny tekst źródłaThe skin is a fascinating outpost of the immune system. It performs a barrier function between the outside environment and the inner body and is also a port of entry for pathogens against which the immune system mounts adapted responses. The skin innate immune defenses control pathogen invasion and perceive also direct physical and chemical environmental changes. Several component of the immune system such as dendritic cells (DC), macrophages (MΦ) and mast cells (MC) participate in initial pathogen clearance and in initiating adaptive memory responses, allowing rapid mobilization of effector T cells and secretion of B cellderived antibodies after secondary pathogen challenge. MCs residing in the dermis exert a determinant alert function through the liberation of various factors and are classically considered as effector cells in the IgE-mediated cutaneous allergic reaction. As emerging now, MC are also involved in immunoregulatory processes during the initiation of adaptive immune responses, the maintenance of peripheral tolerance to skin components and skin regeneration during wound healing. Yet, the crosstalks between MCs and other innate and adaptive immune cells recruited during cutaneous inflammatory conditions have not been elucidated in detail. Here, we report the use of a novel Mast cell fluorescent reporter mouse (RMB), in which we tagged FcεRI+ MCs, with red fluorescence marker tomato (Tdt) and with a conditional ablation system based on concurrent diphtheria toxin receptor (DTR) expression. Using these RMB mice, we visualized MC dynamics and monitored MC interactions with regulatory T lymphocytes (Tregs) after IgE-mediated activation of MCs, in a typical passive cutaneous anaphylaxis (PCA) inflammatory reaction. Using another setting, we further assessed the role of MC during experimental ear skin grafting to reveal their potential influence in skin grafting and rejection. We found that 1) the activation and degranulation of MCs induced by FcεRI crosslinking by multivalent IgE is solely responsible for the PCA reaction and induces the recruitment of highly motile regulatory T cells (Tregs) to the site of inflammation. In these conditions, we found that MC remain sessile and Tregs establish dynamic contacts with MC in the dermis. 2) Further we set up a model system to reveal the molecular requirement for MC-Treg interaction and found that antigen complexed with IgE were able to be presented to Treg in association with major histocompatibility complex class II molecules allowing the formation of stable MC-Treg contacts. 3) Using in vivo skin transplantation model, we showed that conditional ablation of MCs leads to an acceleration of skin transplant rejection in sex-mismatched model (male skin transplant to female). We also found an unexpected impact of MC conditional ablation in sex-matched skin graft (female skin transplant to female) leading to rapid rejection, implying that MCs are essential for the wound healing reaction and the regeneration of tissue continuity after grafting. The aforementioned results point out to an important immunoregulatory role of MC beyond their classically described activator functions in inflamed tissues. The fact that MC constantly interact with Treg during inflammatory processes suggest that MCs could participate in skin homeostasis by exerting tolerogenic functions. These functions remain to be elucidated at the molecular level as presented in the discussion
Aryee, Ken-Edwin. "Utilizing Humanized Mice to Study Human Specific Innate Immune Responses in Immuno-Oncology". eScholarship@UMMS, 2019. https://escholarship.umassmed.edu/gsbs_diss/1041.
Pełny tekst źródłaOzanne, Alexandra. "Activation immunitaire, immuno-sénescence et inflammation : Analyses statistiques des liens avec les comorbidités non liées au VIH lors de l’infection par le VIH". Thesis, Bordeaux, 2017. http://www.theses.fr/2017BORD0846/document.
Pełny tekst źródłaAntiretroviral therapies have improved the survival of HIV-infected people. However, many non-HIVrelated comorbidities occur and represent a major concern in patient care. Activation, inflammation and immunosenescence could play a major role in this process. Many markers can measure those dysfunctions and they are often used without accounting for their possible interdependency. The objectives of this thesis were i) proposing a combination of those markers, ii) assessing the association between the combination of markers and the presence of comorbidities and iii) assessing the association between the combination of markers and the risk of occurrence of comorbidities and mortality in HIV-infected patients included in the sub-study CIADIS from cohort ANRS CO3 Aquitaine. We identified two scores: the cellular and the soluble CIADIS scores. The cellular score was mostly to multimorbidity and occurrence of any kind of new comorbidity. The profile of underlying immune dysfunctions was different when looking separately at the comorbidities. These results support the assumption that several underlying profiles of activation, inflammation and senescence could be involved in the development of different comorbidities. Our results show that integrating new biomarkers in analyses could improve the understanding of comorbidities. We will continue to work on the identification of profiles of immune dysfunctions for some specific comorbidity
Thapa, Navin. "Immune parameters in mycobacterioses, other immune disorders and the effects of immunotherapy". Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313617.
Pełny tekst źródłaMarri, Eswari. "Immune surveillance of activated immune and tumour cells by surfactant protein D". Thesis, Brunel University, 2015. http://bura.brunel.ac.uk/handle/2438/13847.
Pełny tekst źródłaWangkahart, Eakapol. "Immune responses of rainbow trout (Oncorhynchus mykiss) to vaccination and immune stimulation". Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=233634.
Pełny tekst źródłaGaken, Johannes Adrianus. "The role of immune costimulators in the immune gene therapy of cancer". Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297556.
Pełny tekst źródłaAhmed, Ejaz. "Immune mechanisms in atherosclerosis /". Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4612-4/.
Pełny tekst źródłaJuffermans, Nicole Petra. "Immune responses to tuberculosis". [Amsterdam] : Amsterdam : Thela Thesis ; Universiteit van Amsterdam [Host], 2000. http://dare.uva.nl/document/82665.
Pełny tekst źródłaChaithong, Udom. "Immune responses in mosquitoes". Thesis, University of Liverpool, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293724.
Pełny tekst źródłaCain, D. J. "Perioperative neutrophil immune function". Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1568022/.
Pełny tekst źródłaErridge, Clett. "Immune responses to lipopolysaccharide". Thesis, University of Edinburgh, 2002. http://hdl.handle.net/1842/23334.
Pełny tekst źródłaClose, Helen Judith. "Immune evasion in glioma". Thesis, University of Leeds, 2016. http://etheses.whiterose.ac.uk/16103/.
Pełny tekst źródłaSteinfelder, Svenja. "Immune modulation by parasites". Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2007. http://dx.doi.org/10.18452/15682.
Pełny tekst źródłaInfection with Schistosoma mansoni results in the induction of a Th2 immune response, eosinophilia and increased levels of IgE. The water-soluble extract of S. mansoni eggs (SEA) is sufficient to promote TH2 polarization in a dendritic cell-dependent manner. In this thesis, it was demonstrated that IL-4+ CD4+ cells emerge in cultures with SEA-conditioned dendritic cells (DCs) in the presence of IFN-gamma and that SEA inhibits selectively the expression of IL-12 and co-stimulatory markers in DCs on the transcriptional and protein level. To identify the putative protein in S. mansoni eggs mediating a Th2 induction, a gel filtration chromatography of the excretory/secretory egg antigens (ES) was conducted and the fractions tested in vitro. Fractions containing a single band of 30 kD were sufficient to promote IL-4 induction in naïve CD4+ cells. Using N-terminal sequencing this ES-protein was identified as the hepatotoxic S. mansoni ribonuclease omega-1 which displayed both biological functions observed with SEA: inhibition of IL-12 in LPS-stimulated DCs and induction of IL-4+ CD4 cells at a 10 fold lower protein concentration than SEA. In order to understand, if the innate immune receptors TLR2, TLR3, TLR4 or the TLR adaptor molecule MyD88 are involved in the generation of the Th2 response against schistosomal antigens, the respective knock out mice were infected and immunological and pathological parameters were analyzed during acute and chronic phase of infection. This study showed that during S. mansoni infection TLR2, TLR3, TLR4 and TLR activation through the MyD88-dependent pathway are neither required for the induction (priming and polarization) nor for the down-regulation of Th2 responses, however, the fibrotic response against S. mansoni eggs was significantly reduced in MyD88-deficient mice suggesting a detrimental role of this pathway in liver pathology.
Moro, Monica. "Manipulation of anti-tumour immune response by tumour targeting with soluble immuno-modulatory molecules". Thesis, Open University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323271.
Pełny tekst źródłaWarnatsch, Annika. "Impact of proteasomal immune adaptation on the early immune response to viral infection". Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2013. http://dx.doi.org/10.18452/16775.
Pełny tekst źródłaAn efficient immune control of virus infection is predominantly mediated by CD8+ T cells which patrol through the body and eliminate infected cells. Infected cells are recognized when they present viral antigenic peptides on their surface via MHC class I molecules. To make antigenic peptides available for loading on MHC class I complexes, the ubiquitin proteasome system plays a crucial role. Moreover, the induction of the i-proteasome is known to support the generation of MHC class I ligands. Recently, new functions of the i-proteasome have been discovered. Evidence is increasing that the i-proteasome is involved in the protection of cells against oxidative stress. Within this thesis the characteristic of the i-proteasome to protect cells against the accumulation of oxidant-damaged proteins could be linked to its role in improving the generation of MHC class I ligands. It could be demonstrated that during a virus infection in non-immune cells the production of reactive oxygen species by the alternative NADPH oxidase Nox4 is of critical importance resulting in the accumulation of potentially toxic oxidant-damaged proteins. Indeed, within two hours of infection structural virus proteins were oxidized and subsequently poly-ubiquitylated. The concomitant formation of i-proteasomes led to a rapid and efficient degradation of ubiquitylated virus antigens thereby improving the liberation of immunodominant viral epitopes. In conclusion, a so far unknown mechanism to fuel proteasomal substrates into the MHC class I antigen presentation pathway has been revealed. A new protein pool consisting of exogenously delivered viral proteins provides proteasomal substrates in the very early phase of a virus infection. Within the scope of this thesis the i-proteasome has been shown to link the protection against oxidative stress, initiated directly by pathogen recognition, with the generation of antigenic peptides. Together, an effective adaptive immune response is triggered.
Mayer, Andreas. "Optimal immune systems : a ressource allocation and information processing view of immune defense". Thesis, Paris Sciences et Lettres (ComUE), 2017. http://www.theses.fr/2017PSLEE026/document.
Pełny tekst źródłaBiological organisms have evolved diverse immune mechanisms to defend themselves against pathogens. Here we build mathematical models of immune systems optimally tuned to the statistics of pathogens. Beyond molecular details, different immune mechanisms differ in how protection is acquired, processed and passed on to subsequent generations -- differences that may be essential to long-term survival. To explain the observed diversity of strategies we compare the long-term adaptation of populations as a function of the pathogen dynamics that they experience and of the immune strategy that they adopt. We find that the two key determinants of an optimal immune strategy are the frequency and the characteristic timescale of the pathogens. Depending on these two parameters, we identify distinct modes of immunity, including adaptive, innate, bet-hedging and CRISPR-like immunities, which recapitulate the diversity of natural immune systems. Our results carry over to the general question of evolution in fluctuating environments, for which we provide novel analytical results in temporally correlated environments. The adaptive immune system provides protection through a broad repertoire of cells specific to different pathogens. To predict statistical features of well-adapted repertoires we analyze which repertoire minimizes cost of infection for a given distribution of pathogens. The theory predicts that the immune system has more receptors for rare antigens than expected from the frequency of encounters; and individuals exposed to the same infections have sparse repertoires that are largely different, but nevertheless exploit cross-reactivity to provide the same coverage of antigens. Our results follow from a tension between the statistics of pathogen detection, which favor a broader receptor distribution, and the effects of cross-reactivity, which tend to concentrate the optimal repertoire onto a few highly abundant clones. These predictions can be tested in high throughput surveys of receptor and pathogen diversity. We then explicitly consider how the adaptive immune system can learn the statistics of the environments from its past infection history in a Bayesian manner. We show that optimal repertoires can be reached by keeping memory of an infection through the selective proliferation of stimulated cells. The Bayesian perspective on repertoire dynamics provides an unifying conceptual framework to explain a number of features of immunological memory and suggests further experiments
Urrutia, Alejandra. "Defining the boundaries of a healthy immune response using standardized immune monitoring tools". Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066004/document.
Pełny tekst źródłaThe project Milieu Intérieur aims to study the genetic and environmental factors that can have a major impact on occurring immunological variance in healthy human population. This characterization requires the use of standardized immunophenotyping technologies for integrating diverse, complex datasets. With this goal in mind, we used an optimized suite of standardized whole-blood stimulation systems to study the human induced immune response in physiological condition and developed a unique standardized protocol to analyze the ARN signatures upon whole-blood stimulation to test the hypothesis that responses to complex stimuli can be defined by the transcriptional signatures of key cytokines. We found 44 genes, identified using Support Vector Machine learning, which captured the diversity of complex innate immune responses with improved segregation between distinct stimuli. This provides new strategies for dimension reduction of large datasets and for deconvolution of innate immune responses, applicable for characterizing novel immunomodulatory molecules.In a second related study, we aimed to identify the environmental and genetic factors driving innate and adaptive immune cell parameters in homeostatic conditions. To do so, we combined semi-automated flow cytometric analysis of blood leukocytes and genome-wide DNA genotyping in the 1,000 healthy donors included in the collection. We show that smoking, age, gender and latent cytomegalovirus infection, are main drivers of human variation (i.e. numbers of Treg and MAIT cells). These results demonstrated that innate cell parameters are strongly controlled by genetic factors, whereas adaptive cells are driven by life-long environmental exposures. In addition, to help on the public data mining, we developed interactive R-Shiny application including healthy donor reference values for both studies.All together, these results indicate that we developed powerful tools for human system biology approaches to support personalized medecine
Shouval, Dror S. "The Role of Innate Immune IL-10 Receptor Signaling in Controlling Intestinal Immune Responses". Thesis, Harvard University, 2015. http://nrs.harvard.edu/urn-3:HUL.InstRepos:17613727.
Pełny tekst źródłaSmith, Alexia Genese Beck Melinda A. "Obesity alters the immune response to influenza virus infection a mechanism for immune modulation /". Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1606.
Pełny tekst źródłaTitle from electronic title page (viewed Sep. 16, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Nutrition, School of Public Health." Discipline: Nutrition; Department/School: Public Health.
Timmis, Jonathan Ian. "Artificial immune systems : a novel data analysis technique inspired by the immune network theory". Thesis, University of Kent, 2000. https://kar.kent.ac.uk/21989/.
Pełny tekst źródłaBARBERAN, ELISABETH. "Formes frontieres des hepatopathies auto-immunes : cholangite primitive auto-immune ? : a propos de 3 cas". Toulouse 3, 1994. http://www.theses.fr/1994TOU31067.
Pełny tekst źródłaLidehäll, Anna Karin. "Cellular Immune Responses to Cytomegalovirus". Doctoral thesis, Uppsala University, Department of Oncology, Radiology and Clinical Immunology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8578.
Pełny tekst źródłaCytomegalovirus (CMV) is a widespread infection affecting 50-90% of the human population. A typical silent primary infection is followed by life-long persistence in the host under control by virus-specific CD8 (“killer”) and CD4 (“helper”) T cells. Although harmless in most people, CMV may cause disease and sequelae in patients with deficient cellular immunity, such as AIDS patients, recipients of organ transplants and children who have acquired the virus before birth. In this thesis we have characterized the cellular immunity to CMV in immunocompetent subjects, in patients receiving transplants and in infants.
In healthy individuals with latent CMV, the frequencies of CMV-specific CD8 T cells varied considerably between the donors. Within the same individual, the changes over time were usually small. In patients with primary, symptomatic CMV infection, the frequencies of CMV-specific CD8 T cells peaked within the first month after the appearance of symptoms. The frequencies then declined to levels similar to those in latently infected CMV carriers. The CD4 T-cell function followed the same pattern, but with lower peak values.
Immunosuppressed renal transplant patients with latent CMV had CMV-specific CD4 cell function similar to healthy controls. The frequencies of CMV-specific CD8 T cells were also comparable, but their function was impaired. When renal transplant recipients were investigated longitudinally, we found that their CMV-specific T cells decreased rapidly after transplantation. Whereas the frequencies and function of CD8 T cells rebounded within 3 months, CD4 T-cell recovery was impaired during the entire first year after transplantation.
Finally, the frequencies and function of CMV-specific T-cells were investigated in children with congenital and postnatal CMV. CMV-specific CD8 T cells could be detected in even the youngest children, suggesting that these cells can develop early in life. In contrast, CMV specific CD4 T cells were low or absent in the youngest children but increased slowly with age.
Nissinen, A. (Antti). "Humoral immune response to phosphatidylethanol". Doctoral thesis, Oulun yliopisto, 2011. http://urn.fi/urn:isbn:9789514295232.
Pełny tekst źródłaTiivistelmä Runsas alkoholinkulutus aiheuttaa maailmanlaajuisesti merkittäviä terveydellisiä haittoja. Alkoholin aineenvaihduntatuotteet muuttavat kudoksien rakenteita ja aiheuttavat kudosvaurioita. Fosfatidyylietanoli on alkoholin aineenvaihdunnan tuloksena solukalvoilla syntyvä fosfolipidi, jota on tutkittu kahdenkymmenen vuoden ajan lupaavana alkoholin suurkulutuksen merkkiaineena. Tutkimuksen tavoitteena oli selvittää fosfatidyylietanolin immunisoinnin aiheuttamaa vasta-aineiden muodostumista koe-eläinmallina käytetyissä hiirissä sekä määrittää ihmisten plasmanäytteistä vasta-aineita, jotka sitoutuvat fosfatidyylietanoliin. Tutkimuksessa havaittiin immuunivasteen muodostuminen hiirissä, jotka immunisoitiin ihmisen LDL hiukkasiin liitetyllä fosfatidyylietanolilla. Hiiren monoklonaalisia fosfatidyylietanoliin sitoutuvia IgM-luokan vasta-aineita tuotettiin tutkimuksessa soluviljelyn avulla. Fosfatidyylietanolin aiheuttama vasta-aineiden muodostuminen hiirillä johdatti mittaamaan fosfatidyylietanoliin sitoutuvia vasta-aineita myös ihmisiltä. Tutkimuksessa havaittiin fosfatidyylietanoliin sitoutuvia IgG-, IgA- ja IgM-luokan vasta-aineita alkoholin suurkuluttajilla, alkoholihaimatulehdusta sairastavilla ja verrokkihenkilöillä. Vasta-aineiden pitoisuudet olivat alkoholia runsaasti käyttävillä koehenkilöillä merkitsevästi pienemmät kuin verrokkiryhmällä. Matalat IgA-vasta-ainepitoisuudet osoittautuivat aineistossa paremmaksi alkoholin suurkulutuksen osoittajiksi kuin eräät tavanomaisesti käytetyt alkoholinkäytön merkkiaineet. Plasman fosfatidyylietanoli-vasta-aineiden ja alkoholin aineenvaihdunnan seurauksena syntyvien malondialdehydi-asetaldehydi-addukteihin sitoutuvien vasta-aineiden määrän välillä havaittiin merkitsevä yhteys, jota ei havaittu rasvojen hapettumisen seurauksena syntyvien fosfokoliini-vasta-aineiden ja fosfatidyylietanoli-vasta-aineiden välillä. Tutkimus osoittaa, että hiirillä voidaan aikaansaada vasta-ainevälitteinen immuunivaste, kun ne rokotetaan ihmisen LDL-hiukkaseen liitetyllä fosfatidyylietanolilla. Fosfatidyylietanoliin spesifisesti sitoutuvien monoklonaalisten vasta-aineiden tuottaminen voi tulevaisuudessa johtaa immunologisen diagnostisen määritysmenetelmän kehittämiseen. Fosfatidyylietanoliin sitoutuvien plasman vasta-aineiden havaitseminen viittaa siihen, että fosfatidyylietanoli on vasta-ainevälitteisen immuunivasteen kohde myös ihmisillä
Lundgren, Christian. "Immune responses in urogenital cancer". Thesis, Uppsala universitet, Institutionen för biologisk grundutbildning, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-269894.
Pełny tekst źródłaDegabriele, Robert, University of Western Sydney i of Informatics Science and Technology Faculty. "Stress and the immune network". THESIS_FIST_XXX_Degabriele_R.xml, 1999. http://handle.uws.edu.au:8081/1959.7/406.
Pełny tekst źródłaDoctor of Philosophy (PhD)
Chan, Erwin Pai Hsiung. "Immune reactivity to metal implants". University of Western Australia. School of Anatomy and Human Biology, 2009. http://theses.library.uwa.edu.au/adt-WU2009.0194.
Pełny tekst źródłaOdeberg, Jenny. "Human cytomegalovirus immune evasion strategies /". Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-126-8.
Pełny tekst źródłaRentenaar, Robert Jan. "Immune responsiveness in immunosuppressed patients". [Amsterdam : Amsterdam : Thela Thesis] ; Universiteit van Amsterdam [Host], 2001. http://dare.uva.nl/document/59814.
Pełny tekst źródłaLidehäll, Anna Karin. "Cellular immune responses to cytomegalovirus /". Uppsala : Acta Universitatis Upsaliensis : Universitetsbiblioteket [distributör], 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8578.
Pełny tekst źródłaShbat, Layla. "Immune modulation in cardiovascular disease". Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103617.
Pełny tekst źródłaLe rôle de la réponse immunitaire adaptative dans l'hypertension et l'athérosclérose commence à être apprécié. Cependant, il n'est pas clair que les lymphocytes T régulateurs (Tregs) jouent un rôle dans ces deux pathologies. Dans le but d'éclaircir le rôle de ces lymphocytes, le contenu en Tregs a été déterminé à l'aide de cytométrie de flux dans la rate et l'aorte de deux modèles murins, l'hypertension induite par l'angiotensine (Ang) II et l'athérosclérose induite par une diète riche en gras (DRG) dans des souris knockout pour l'apolipoprotéine E (apoE-/-) exagérée par la surexpression de l'endothéline (ET)-1. Deux groupes de souris ont été étudiés. Dans le premier groupe, des souris mâles C57BL/6 de 12 semaines ont été infusées ou pas avec de l'Ang II (1 µg/kg/min, s.c.) pendant 2 semaines. Dans le second groupe, des souris mâles C57BL/6 de 8 semaines transgéniques surexprimant l'ET-1 dans les cellules endothéliales (eET-1), apoE-/-, eET-1/apoE-/- et sauvages (WT) ont été nourries avec une DRG ou une diète normale (DN) pendant 8 semaines. Les souris infusées avec l'Ang II présentaient une tendance à l'augmentation de plusieurs sous-populations de lymphocytes T incluant les Tregs naturels (CD4+CD25+Foxp3+) dans la rate. Par contre, au niveau de l'aorte les Tregs naturels tendaient à diminuer. Dans l'étude de l'athérosclérose, une augmentation des Tregs (CD4+CD25+) a été observée dans la rate des souris eET-1. La DRG a réduit le contenu de Tregs dans la rate des souris WT et eET-1 et tendait à accroître les Tregs naturels dans la rate des eET-1/apoE-/-. Au niveau de l'aorte, la DRG a augmenté les Tregs et tendait à accroître les Tregs naturels dans les eET-1 et tendait à diminuer ces lymphocytes dans les eET-1/apoE-/-. Le manque de changements significatifs limite la possibilité de tirer des conclusions. Cependant, les résultats suggèrent que l'ET-1 et la DRG ont un impact sur la population de Tregs dans la rate et l'aorte. Des animaux additionnels et/ou un raffinement des techniques pourraient donner des résultats plus définitifs.
Furze, Rebecca Claire. "Immune responsiveness in Trichinella infection". Thesis, Imperial College London, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.424923.
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