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Artykuły w czasopismach na temat "ICOLL"

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Gale, Emma, Charitha Pattiaratchi i Roshanka Ranasinghe. "Processes driving circulation, exchange and flushing within intermittently closing and opening lakes and lagoons". Marine and Freshwater Research 58, nr 8 (2007): 709. http://dx.doi.org/10.1071/mf06121.

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The circulation and exchange between two intermittently closing and opening lakes and lagoons (ICOLLs) and the ocean were analysed using salinity and current meter data. Wamberal Lagoon was shallow (~2.5 m maximum depth) with a small (<1 km2) waterway area and a short opening duration (2 weeks), and Smiths Lake was deeper (~5 m maximum depth) with a larger (~11 km2) waterway area and a longer opening duration (4 months). An absence of river inflow and a restricted sill type inlet channel characterised both systems. The results showed that the smaller ICOLL exhibited a salinity structure similar to a partially or well-mixed estuary, whereas the larger ICOLL exhibited stronger separation of flow with a salt wedge-type structure. Both ICOLLs had strong current velocities in the surface water during ebb tide. The results also demonstrated that tidal effects controlled the circulation and exchange in the smaller ICOLL, whilst the wind also had a significant influence. In the larger ICOLL, subtidal effects over the fortnightly tidal cycle significantly influenced the circulation and exchange, but the influence of tide and wind effects was weaker. An analysis of the flushing for the two ICOLLs illustrated that the timescales were an order of magnitude different but comparable to the duration of opening for each ICOLL, ranging from 4 days in the smaller ICOLL (Wamberal Lagoon) to 113 days in the larger ICOLL (Smiths Lake). This research suggests that intermittent estuarine systems may be quite complex and variable within the same regional area, and consequently throughout the world.
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Suara, Kabir, Neda Mardani, Helen Fairweather, Adrian McCallum, Chris Allan, Roy Sidle i Richard Brown. "Observation of the Dynamics and Horizontal Dispersion in a Shallow Intermittently Closed and Open Lake and Lagoon (ICOLL)". Water 10, nr 6 (13.06.2018): 776. http://dx.doi.org/10.3390/w10060776.

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Souza, Luiz A. de, Luiz A. F. da Silva, Benito J. N. A. de Oliveira, Elisângela de P. S. Lacerda, Marcelo E. Beletti, Aliny P. de Lima, Tais Andrade Dias i Duvaldo Eurides. "Método imunomagnético associado ao meio MesenCult® na obtenção de células mononucleares da medula óssea de coelhos negativas para o anticorpo monoclonal CD45". Pesquisa Veterinária Brasileira 36, nr 4 (kwiecień 2016): 339–44. http://dx.doi.org/10.1590/s0100-736x2016000400014.

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Resumo O objetivo detse artigo é de descrever um protocolo de isolamento das células mononucleares da medula óssea de coelhos, seguido de purificação celular por depleção negativa com o anticorpo monoclonal CD45 e posterior expansão em meio de cultura MesenCult®. Dez coelhos machos adultos, da raça Nova Zelândia, com idade média de 1,0±0,2 anos e peso médio 3,5±0,24kg, foram utilizados para padronização da metodologia. O isolamento das células mononuclares da medula óssea foi realizado pelo gradiente de densidade Ficoll-paque® e a purificação e obtenção das células- pela depleção negativa com o anticorpo monoclonal CD45 em base imunomagnética. A população celular obtida foi expandida posteriormente em meio de cultura MesenCult®. No isolamento pelo gradiente de icoll-Paque® foi obtido um rendimento médio de 7,31x106 células/mL. Após purificação e obtenção das possíveis células-tronco mesenquimais pela base imunomagnética, houve um decréscimo do rendimento para 2,28x106 células/mL, mas o processo de expansão foi incrementado pelo cultivo celular. Os resultados indicaram que as células obtidas da fração mononuclear da medula óssea, cultivadas in vitro foram capazes de gerar células aderentes 24 horas após o cultivo, com predominância de células fibroblastóides sugestivas de células-tronco mesenquimais. Concluiu-se que a obtenção de células-tronco mesenquimais pode ser alcançada após purificação das células mononucleares da medula óssea de coelhos pelo método imunomagético, o meio de cultura MesenCult® proporciona um ambiente adequado para a rápida expansão in vitro e o número de passagens exerce influência negativa sobre as características morfológicas das células.
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tanaka, chichiro, Manabu Fujimoto, Shinichi Sato, Kazuhiko Takehara i Minoru Hasegawa. "Role of inducible costimulator and inducible costimulator ligand in bleomycin-induced lung and skin fibrosis model (94.22)". Journal of Immunology 182, nr 1_Supplement (1.04.2009): 94.22. http://dx.doi.org/10.4049/jimmunol.182.supp.94.22.

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Abstract Inducible costimulator (ICOS) is a CD28 homolog with an expression restricted to T cells, and its only interaction partner, ICOS ligand (ICOSL), is highly expressed on B cells, macrophage, and dendritic cells. To assess the role of ICOS-ICOSL signaling pathway in tissue fibrosis, bleomycin-induced lung and skin fibrosis model was examined in mice deficient for ICOS and/or ICOSL. Daily subcutaneous injection of bleomycin induced fibrosis in the lungs and skin. The loss of ICOS improved the survival rate as a result of ameliorated inflammatory cell infiltration, collagen deposition, and proinflammatory cytokine expression. By contrast, the deficiency of ICOSL or both ICOS and ICOSL reduced the survival rate in consequence of aggravated inflammation and tissue fibrosis. Interestingly, ICOSL expression on macrophage and B cell was ~300% elevated in ICOS-deficient mice compared with wild type mice during this process. Thus, ICOSL expression levels inversely associated with the severity of this mouse model. These findings suggest that ICOSL expression on antigen presenting cells has regulatory roles independent of ICOS-ICOSL pathway for the development of bleomycin-induced tissue fibrosis.
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Bridle, Rodney. "ICOLD Embankment Dams Committee Activities, ICOLD Johannesburg, May 2016". Dams and Reservoirs 27, nr 2 (sierpień 2017): 87–91. http://dx.doi.org/10.1680/jdare.17.00013.

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Raineri, Davide, Giuseppe Cappellano, Beatrice Vilardo, Federica Maione, Nausicaa Clemente, Elena Canciani, Elena Boggio i in. "Inducible T-Cell Costimulator Ligand Plays a Dual Role in Melanoma Metastasis upon Binding to Osteopontin or Inducible T-Cell Costimulator". Biomedicines 10, nr 1 (27.12.2021): 51. http://dx.doi.org/10.3390/biomedicines10010051.

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Recently, we demonstrated that inducible T-cell costimulator (ICOS) shares its unique ligand (ICOSL) with osteopontin (OPN), and OPN/ICOSL binding promotes tumor metastasis and angiogenesis in the 4T1 breast cancer model. Literature showed that OPN promotes melanoma metastasis by suppressing T-cell activation and recruiting myeloid suppressor cells (MDSC). On the opposite, ICOS/ICOSL interaction usually sustains an antitumor response. Here, we engineered murine B16F10 melanoma cells, by transfecting or silencing ICOSL. In vitro data showed that loss of ICOSL favors anchorage-independent growth and induces more metastases in vivo, compared to ICOSL expressing cells. To dissect individual roles of the three molecules, we compared data from C57BL/6 with those from OPN-KO, ICOS-KO, and ICOSL-KO mice, missing one partner at a time. We found that OPN produced by the tumor microenvironment (TME) favors the metastasis by interacting with stromal ICOSL. This activity is dominantly inhibited by ICOS expressed on TME by promoting Treg expansion. Importantly, we also show that OPN and ICOSL highly interact in human melanoma metastases compared to primary tumors. Interfering with this binding may be explored in immunotherapy either for nonresponding or patients resistant to conventional therapies.
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Luker, Andrea, Joseph Cornelius Lownik i Daniel Conrad. "ADAM10 is a novel sheddase of Inducible Costimulatory Ligand (ICOSL)." Journal of Immunology 198, nr 1_Supplement (1.05.2017): 195.18. http://dx.doi.org/10.4049/jimmunol.198.supp.195.18.

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Abstract ICOSL is an important co-stimulatory molecule involved in the development of TH2 responses through germinal center reactions. Although not well defined, the regulation of ICOSL is known to occur through its interaction with ICOS. Evidence suggests surface expression levels are regulated by a catabolic event, and not through internalization. Here we confirm that regulation of ICOSL is mediated by the metalloproteinase ADAM10. Cleavage of recombinant ICOSL results in an amino-terminal fragment of approximately 3kDa, which is blocked by an ADAM10-specific inhibitor. Recombinant and cell-based cleavage assays suggest that ADAM17 can also cleave ICOSL. In vivo, we observed a ten-fold increase in ICOSL expression in ADAM10B−/− mice compared to wildtype, a phenomenon that was absent in ADAM17B−/− mice. This suggests that ADAM10 is the primary physiological sheddase of ICOSL, while ADAM17 may serve as a secondary sheddase. Additionally, ADAM10B−/− mice develop a significantly diminished T follicular helper (TFH) cell population in response to NP-KLH/alum immunization. Together, these data provide insight into the regulatory mechanism between ICOS/ICOSL and suggest ADAM10 may be a potential therapeutic target for attenuating antibody driven diseases.
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Landuyt, Ashley E., Barbara J. Klocke, Lennard W. Duck, Keri M. Kemp, Rachel Q. Muir, Melissa S. Jennings, Samuel I. Blum i in. "ICOS ligand and IL-10 synergize to promote host–microbiota mutualism". Proceedings of the National Academy of Sciences 118, nr 13 (22.03.2021): e2018278118. http://dx.doi.org/10.1073/pnas.2018278118.

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Genome-wide association studies have identified ICOSLG, which encodes the inducible costimulator ligand (ICOSLG or ICOSL) as a susceptibility locus for inflammatory bowel disease. ICOSL has been implicated in the enhancement of pattern recognition receptor signaling in dendritic cells, induction of IL-10 production by CD4 T cells, and the generation of high-affinity antibodies to specific antigens—all of which can potentially explain its involvement in gastrointestinal inflammation. Here, we show that murine ICOSL deficiency results in significant enrichment of IL-10–producing CD4 T cells particularly in the proximal large intestine. Transient depletion of IL-10–producing cells from adult ICOSL-deficient mice induced severe colonic inflammation that was prevented when mice were first treated with metronidazole. ICOSL-deficient mice displayed reduced IgA and IgG antibodies in the colon mucus and impaired serum antibody recognition of microbial antigens, including flagellins derived from mucus-associated bacteria of the Lachnospiraceae family. Confirming the synergy between ICOSL and IL-10, ICOSL deficiency coupled with CD4-specific deletion of the Il10 gene resulted in juvenile onset colitis that was impeded when pups were fostered by ICOSL-sufficient dams. In this setting, we found that both maternally acquired and host-derived antibodies contribute to the life anti-commensal antibody repertoire that mediates this protection in early life. Collectively, our findings reveal a partnership between ICOSL-dependent anti-commensal antibodies and IL-10 in adaptive immune regulation of the microbiota in the large intestine. Furthermore, we identify ICOSL deficiency as an effective platform for exploring the functions of anti-commensal antibodies in host–microbiota mutualism.
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Williamson, Tracey, Andy Hughes, Ian Hope i Rafael Monroy. "ICOLD technical tours". Dams and Reservoirs 27, nr 1 (kwiecień 2017): 2–7. http://dx.doi.org/10.1680/jdare.16.00050.

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Williamson, Tracey. "ICOLD – first impressions". Dams and Reservoirs 19, nr 4 (grudzień 2009): 155. http://dx.doi.org/10.1680/dare.2009.19.4.155.

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Rozprawy doktorskie na temat "ICOLL"

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Spooner, Daniel Ron, i n/a. "Nutrient, organic carbon and suspended solid loadings in two ICOLLs, NSW Australia : biogeochemical responses". University of Canberra. Resource, Environmental & Heritage Sciences, 2005. http://erl.canberra.edu.au./public/adt-AUC20070129.130745.

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Intermittently Closed and Open Lake Lagoons (ICOLLs) are very common along the southern NSW coastline. Expanding urban populations are expanding and these systems are under increasing pressure from anthropogenic activities that change landscape processes and significantly alter the amounts of organic and inorganic constituents entering their waters. Once efficient cycling of nutrients in ICOLLs is overcome, the symptoms of eutrophication establish and the entire ecosystem suffers. These systems have great ecological, social, and economic values that require insightful, well balanced, and educated management to promote sustainable use of these often-sensitive areas. Corunna and Nangudga Lake are ICOLLs in the Eurobodalla Shire on the south coast of NSW. These two ICOLLs receive discharges from catchments covered by native vegetation and grassland. The primary objective of this research component was to quantify catchment exports of total nitrogen (TN), total phosphorus (TP), suspended solids (SS), particulate organic matter (POM) and dissolved organic carbon (DOC) from three small coastal sub catchments that deliver constituents into Corunna and Nangudga Lakes. As part of this investigation the fates of catchment loads in the ICOLLs were established focusing on the lakes water column response to catchment loads and the biogeochemical cycling of nitrogen and phosphorus in sediments.
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Haines, Philip Edward, i n/a. "Physical and Chemical Behaviour and Management of Intermittently Closed and Open Lakes and Lagoons (ICOLLs) in NSW". Griffith University. School of Environmental and Applied Science, 2006. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20070221.132729.

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The term 'Intermittently Closed and Open Lake or Lagoon (ICOLL)' has been adopted in NSW to described wave dominated barrier estuaries with an intermittent connection to the ocean. ICOLLs can also be found in south east Queensland, south-west Western Australia, and some parts of Victoria and Tasmania, although they are not the dominant estuary type as in NSW. From an international perspective, ICOLLs are also found in South Africa, New Zealand, Mexico and the Atlantic coast of Brazil and Uruguay. Within NSW, ICOLLs are mostly located south of Sydney, due to the high wave activity and close proximity of the Great Dividing Range to the coast, which results in small coastal catchments and thus small fluvial and sediment runoff. The distinguishing difference between ICOLLs and other estuary types is the variable condition of their entrances, which also makes them the most sensitive type of estuary to human interference (HRC, 2002; Boyd et al., 1992). The sensitivity of ICOLLs to external inputs has been described in this thesis based on their morphometric characteristics, which includes their size, shape and predominant entrance condition. NSW ICOLLs exhibit a wide range of physical conditions. Some ICOLLs are rarely open to the ocean, while others are rarely closed. Also, some ICOLLs have experienced extensive development within their catchments, while some are located mostly or wholly within National Parks and other protected reserves. When closed, ICOLLs behave like terminal lakes, retaining and assimilating 100% of the external inputs delivered to the system. When open, tidal flushing assists with advection and dispersion of inputs, however, significant tidal attenuation across the entrance still limits opportunities for effective removal of pollutants. The majority of NSW ICOLLs are considered to be mostly closed (i.e., have a closed entrance for more than 60% of the time), while remaining ICOLLs tend to be mostly open (i.e., have a closed entrance for less than 20% of the time). Few ICOLLs have entrances that are open and closed for roughly equal proportions of time, thus resulting in a distinctive bimodal behaviour of entrance condition (i.e., mostly open or mostly closed). NSW ICOLLs tend to be mostly closed unless (i) the catchment is larger than 100km2, and/or (ii) the exposure of the entrance to ocean swell waves is less than 60 degrees and/or (iii) the entrance channel contains geomorphic controls (e.g. shallow bedrock outcrops). Unless opened artificially, ICOLLs will generally remain closed until a sufficient volume of catchment runoff accumulates within the waterway to increase water levels to a level that overtops (breaches) the entrance sand berm. Once breached, high velocity flows over the berm cause scour and the development of a formalised entrance channel, which increases exponentially until an optimum width and depth has been reached (determined by the hydrostatic head, geomorphic controls and tidal conditions at the time). Following entrance breakout and lowering of the lagoon level, sand is reworked back into the entrance under the influence of flood tides and wave processes. The environmental condition of ICOLLs has generally been assumed as being dependent on the state of the catchment and the associated input of nutrients (form and magnitude) to the system. Biogeochemical processes also are reported to influence the condition of ICOLLs, particularly denitrification, which is controlled by the organic load on the bed and the extent of benthic algae and macrophytic productivity. In addition to this, however, it is demonstrated that the predominant and prevailing entrance conditions (i.e. open or closed) also influence the physical, chemical and biological environments. ICOLLs are particularly susceptible to the impacts of future climate change. This thesis provides a description of expected impacts on NSW ICOLLs environments associated in response to future climate changes, based on a detailed appreciation of physical processes and their follow-on consequences. Impacts on ICOLLs are expected as a result of increasing sea level, altered rainfall patterns, and modified offshore wave climate. A survey of relevant government officials has revealed that more than 50% of NSW ICOLLs are artificially opened before water levels reach the height of the natural entrance sand berm. Artificial entrance opening is mostly carried out to mitigate inundation of public and/or private assets around ICOLL foreshores, such as roads, backyards, farming lands and on-site sewage (septic) systems. Truncation of the hydraulic regime of ICOLLs can modify other physical, chemical and biological processes, and can result in deleterious impacts such as the terrestrialisation of estuarine wetlands and foreshores. Few statutory environmental planning mechanisms protect ICOLLs from future degradation. This thesis has identified the key issues that potentially compromise ICOLL integrity and sustainability, which include the expected future population growth in coastal NSW (thus increasing pressure for intensification of development within ICOLL catchments), future climate change (particularly increases in sea level), and the increased demand for amenity, particularly during summer holiday periods (i.e. 'summer impacts'). A series of management models have been developed to address key issues. The models comprise a suite of strategies that target future development and existing management practices, through a range of new or modified planning instruments. Models for the future management of ICOLL entrances aim to prevent artificial openings in the long-term. This requires, however, the systematic relocation, raising or flood-proofing of public and private assets that have been established on land that is potentially subject to inundation. Increasing sea levels in the future will compound the need for improved entrance management. Pro-active, integrated and adaptive management strategies need to be implemented today to minimise the on-going conflict and potential for continued environmental degradation in the future.
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Haines, Philip Edward. "Physical and Chemical Behaviour and Management of Intermittently Closed and Open Lakes and Lagoons (ICOLLs) in NSW". Thesis, Griffith University, 2006. http://hdl.handle.net/10072/367425.

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The term 'Intermittently Closed and Open Lake or Lagoon (ICOLL)' has been adopted in NSW to described wave dominated barrier estuaries with an intermittent connection to the ocean. ICOLLs can also be found in south east Queensland, south-west Western Australia, and some parts of Victoria and Tasmania, although they are not the dominant estuary type as in NSW. From an international perspective, ICOLLs are also found in South Africa, New Zealand, Mexico and the Atlantic coast of Brazil and Uruguay. Within NSW, ICOLLs are mostly located south of Sydney, due to the high wave activity and close proximity of the Great Dividing Range to the coast, which results in small coastal catchments and thus small fluvial and sediment runoff. The distinguishing difference between ICOLLs and other estuary types is the variable condition of their entrances, which also makes them the most sensitive type of estuary to human interference (HRC, 2002; Boyd et al., 1992). The sensitivity of ICOLLs to external inputs has been described in this thesis based on their morphometric characteristics, which includes their size, shape and predominant entrance condition. NSW ICOLLs exhibit a wide range of physical conditions. Some ICOLLs are rarely open to the ocean, while others are rarely closed. Also, some ICOLLs have experienced extensive development within their catchments, while some are located mostly or wholly within National Parks and other protected reserves. When closed, ICOLLs behave like terminal lakes, retaining and assimilating 100% of the external inputs delivered to the system. When open, tidal flushing assists with advection and dispersion of inputs, however, significant tidal attenuation across the entrance still limits opportunities for effective removal of pollutants. The majority of NSW ICOLLs are considered to be mostly closed (i.e., have a closed entrance for more than 60% of the time), while remaining ICOLLs tend to be mostly open (i.e., have a closed entrance for less than 20% of the time). Few ICOLLs have entrances that are open and closed for roughly equal proportions of time, thus resulting in a distinctive bimodal behaviour of entrance condition (i.e., mostly open or mostly closed). NSW ICOLLs tend to be mostly closed unless (i) the catchment is larger than 100km2, and/or (ii) the exposure of the entrance to ocean swell waves is less than 60 degrees and/or (iii) the entrance channel contains geomorphic controls (e.g. shallow bedrock outcrops). Unless opened artificially, ICOLLs will generally remain closed until a sufficient volume of catchment runoff accumulates within the waterway to increase water levels to a level that overtops (breaches) the entrance sand berm. Once breached, high velocity flows over the berm cause scour and the development of a formalised entrance channel, which increases exponentially until an optimum width and depth has been reached (determined by the hydrostatic head, geomorphic controls and tidal conditions at the time). Following entrance breakout and lowering of the lagoon level, sand is reworked back into the entrance under the influence of flood tides and wave processes. The environmental condition of ICOLLs has generally been assumed as being dependent on the state of the catchment and the associated input of nutrients (form and magnitude) to the system. Biogeochemical processes also are reported to influence the condition of ICOLLs, particularly denitrification, which is controlled by the organic load on the bed and the extent of benthic algae and macrophytic productivity. In addition to this, however, it is demonstrated that the predominant and prevailing entrance conditions (i.e. open or closed) also influence the physical, chemical and biological environments. ICOLLs are particularly susceptible to the impacts of future climate change. This thesis provides a description of expected impacts on NSW ICOLLs environments associated in response to future climate changes, based on a detailed appreciation of physical processes and their follow-on consequences. Impacts on ICOLLs are expected as a result of increasing sea level, altered rainfall patterns, and modified offshore wave climate. A survey of relevant government officials has revealed that more than 50% of NSW ICOLLs are artificially opened before water levels reach the height of the natural entrance sand berm. Artificial entrance opening is mostly carried out to mitigate inundation of public and/or private assets around ICOLL foreshores, such as roads, backyards, farming lands and on-site sewage (septic) systems. Truncation of the hydraulic regime of ICOLLs can modify other physical, chemical and biological processes, and can result in deleterious impacts such as the terrestrialisation of estuarine wetlands and foreshores. Few statutory environmental planning mechanisms protect ICOLLs from future degradation. This thesis has identified the key issues that potentially compromise ICOLL integrity and sustainability, which include the expected future population growth in coastal NSW (thus increasing pressure for intensification of development within ICOLL catchments), future climate change (particularly increases in sea level), and the increased demand for amenity, particularly during summer holiday periods (i.e. 'summer impacts'). A series of management models have been developed to address key issues. The models comprise a suite of strategies that target future development and existing management practices, through a range of new or modified planning instruments. Models for the future management of ICOLL entrances aim to prevent artificial openings in the long-term. This requires, however, the systematic relocation, raising or flood-proofing of public and private assets that have been established on land that is potentially subject to inundation. Increasing sea levels in the future will compound the need for improved entrance management. Pro-active, integrated and adaptive management strategies need to be implemented today to minimise the on-going conflict and potential for continued environmental degradation in the future.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Environmental and Applied Science
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Enbom, Anna. "Enklare väg in i ett nytt språk : En webbkurs för nybörjare i arabiska". Thesis, Mittuniversitetet, Institutionen för informationsteknologi och medier, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:miun:diva-18921.

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Detta examensarbete går ut på att utveckla en webbplats som riktar sig till svenskar som vill lära sig arabiska. Syftet med webbplatsen är att minska tröskeln till att lära sig arabiska. En stor del av arbetet har bestått i att ta del av litteratur om språkinlärning, språkutbildning och datorstödd språkinlärning, samt att studera andra webbplatser. Den webbplats jag har skapat bygger till stor del på en MySQL-databas. Webbplatsen är skapad med PHP, HTML, CSS, JavaScript, jQuery och AJAX. Det finns ett gränssnitt där administratörer kan lägga in nya ord och meningar. Orden och meningarna i databasen har lagrats med morfemen åtskilda så långt det är möjligt. En fördel är att det underlättar visualiseringar, utbyggnad av nya funktioner och att det går snabbare för administratörer att lägga in nya ord och meningar. Några av de funktioner som finns på webbplatsen är: Varje ord i ordlistan visas med sina viktigaste böjningsformer. För varje ord kan man se hur det är uppbyggt i bokstäver. För varje ord kan man se vilka meningar det ingår i, för varje mening kan man klicka på valfritt ord för att få mer information om ordet. Varje mening visas både med sin översättning och en ordagrann översättning. Användare kan spara valfria ord och förhöras på dem. För att värdera webbplatsen har jag bland annat genomfört en användarundersökning. Resultatet visar att webbplatsen som helhet är bra och att det finns ett behov av den, samtidigt som utseendet och användarvänligheten kan förbättras.
The aim of this project is to develop a website for swedes that want to learn Arabic. The purpose of the website is to facilitate the learning of Arabic. A large part of the project has been dedicated to study second language acquisition, language education and computer-aided language learning as well as to study other websites. The website I have created is based on a MySQL database. The website is built with PHP, HTML, CSS, JavaScript, jQuery and AJAX. Apart from the website there is an interface for administrators where they can add words and sentences to the website. The words and sentences in the database are stored so that morphemes are separated as far as possible. An advantage with that solution is that it facilitates visualizations, creation of new functions and that administrators can add new words and sentences with less effort. Some of the functions that the website offers are: Each word in the wordlist are represented with its most common inflections. Each word can be broken up into letters. For each word you can click to find sentences where the word is included, for each sentence you can click on a word to find more information about it. Each sentence are represented with both a translation and a word by word translation. Users can save words and be tested on them. To value the website a survey has been done. The survey shows that the website in general is good and that there is a need for it, while the look and the navigation needs to be improved.
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Lun, Suen Caesar, i 藺蓀. "An integrated approach to computer-assisted language learning (ICALL)". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B45014838.

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Norman, Renee Adelle. "House of mirrors, performing autobiograph(icall)y in language/education". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape7/PQDD_0017/NQ46401.pdf.

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Sentance, Susan. "Recognising and responding to English article usage errors : an ICALL based approach". Thesis, University of Edinburgh, 1993. http://hdl.handle.net/1842/20176.

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Artificial Intelligence techniques are increasingly being used to enhance the area of Computer-Aided Instruction. This thesis is concerned with the area of Computer-Aided Language Learning, a subset of Computer-Aided Instruction, and demonstrates how various Artificial Intelligence techniques can be incorporated into a language system to produce an intelligent educational tool. In this thesis, the focus is on the use of English articles, which is a subtle area of the English language with which even advanced students of English have difficulty. This thesis describes Artcheck, an intelligent Computer-Aided Language Learning (ICALL) system which detects, analyses and responds to English article usage errors. This system has three main features: it has knowledge of the article usage domain; it dynamically creates a model of the student; and it adapts to the individual student. The system's knowledge of the domain consists of a set of article usage rules which reflect standard teaching practice. The information necessary to apply the rules is extracted at the natural language processing stage, and includes structural and contextual information. The system models the state of the student's knowledge at all times, in order to give informative explanations to the student about any errors which are made. It is able to generate mal-rules which account for consistent errors made by the student, using version spaces and the candidate elimination algorithm. The student model can be described as dynamic because the generation of mal-rules can create new parts of the student model, in response to student behaviour, which are not pre-determined by the system designer. The system responds to individual students by giving explanations of errors which are tailored to the student's level of ability and preferred learning style.
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McCallum, Roisin. "Organic matter and nitrogen cycling in a heavily modified coastal lagoon". Thesis, Edith Cowan University, Research Online, Perth, Western Australia, 2022. https://ro.ecu.edu.au/theses/2552.

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Coastal waterbodies and their catchments have been highly modified, leading to altered flushing and eutrophication. Strategies to manage water flow to either maintain water levels or reduce salt-water intrusion and mitigate impacts to coastal waterbodies include engineering approaches such as the construction of surge barriers and river diversions and manipulation of sandbars. Climate change is increasingly impacting coastal waterbodies with predictions of increased drying and significant changes to rainfall patterns. Consequently, engineering management strategies are likely to increase, but it is unclear how biogeochemistry and benthic cycling in coastal waterbodies will be affected, and how to manage the likely eutrophication issues that ensue. Therefore, the aim of this project was to determine how organic matter and nutrients are transported and cycled within a heavily modified intermittently closed/open lakes and lagoons (ICOLL). The Vasse Wonnerup Wetland System (VWWS) is a modified eutrophic ICOLL in southwestern Australia. It has been managed for over 100 years and has multiple surge barriers, river diversions, an oxygenation plant, and an artificially managed sandbar. In addition, significant portions of the VWWS seasonally dry out, making it an ideal system to study the effects of climate change to coastal systems which are likely to experience similar modifications as the VWWS. Stable isotope analyses and mixing models showed that the particulate organic matter (POM) in the system is derived mainly from autochthonous sources (fringing vegetation and aquatic macrophytes). Similarly, compound-specific stable isotopes showed that the sources of dissolved organic matter (DOM) are mainly autochthonous and dominated by dissolved organic nitrogen (DON). The extremely low ( < detection limit) concentrations of dissolved inorganic nitrogen (DIN; nitrate and ammonium) in the basin water column suggests that DON is crucial to sustaining a DIN supply in the VWWS through decomposition and tight cycling between DON and DIN. Currently, national and international management guidelines focus on inorganic nutrient concentrations as indicators of unacceptable concentrations (trigger values) and management strategies are generally focused upon reducing allochthonous (external) dissolved inorganic nutrients (i.e., nitrate, ammonium, and phosphate). This study shows that the focus of management on inorganic nutrients may not be well placed in this type of system. Benthic flux experiments demonstrated that water column DO and seasonal drying of the sediment did not affect dissolved organic C, N or P fluxes significantly but did influence benthic metabolism with higher rates occurring in high water column DO conditions. Despite this, benthic metabolism remained anaerobic. Surprisingly, decreasing water column DO did not influence net greenhouse gas (GHG) emissions indicating increasing water column DO will not decrease GHG emissions. Oxygenation of the water column did increase N removal, with higher net N2 effluxes with increasing water column DO. Bioavailable nitrogen pools the water column were supplemented in low DO conditions by N2O, with consumption of N2O occurring during dark hours. The lack of significant effects from DO manipulation treatments on many of the measured nutrient species indicate that maintenance of water column oxic conditions, regardless of the concentrations are unlikely to be effective in promoting removal or storage of nutrients in eutrophic systems. Increasing drying out of coastal waterbodies will have impacts on benthic metabolism, however this issue may become system specific depending on sandbar and surge barrier management strategies influencing water levels. Overall, this study confirmed the importance of autochthonous OM contributions and cycling in an ICOLL, whilst highlighting the impacts of engineered modifications in this type of coastal waterbody and its catchment.
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Briet, Claire. "Déviation de l’auto-immunité chez la souris NOD invalidée pour la voie ICOS/ICOSL". Thesis, Paris 5, 2012. http://www.theses.fr/2012PA05T057/document.

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Le modèle murin le plus utilisé pour le diabète de type 1 est la souris NOD. L’activation des lymphocytes T autoréactifs vis à vis des cellules béta nécessite la reconnaissance par le TCR de l’auto antigène présenté par le CMH ainsi que des signaux de co stimulation. Nous apportons la preuve que la voie de costimulation ICOS/ICOSL est indispensable au développement du diabète chez la souris NOD. En effet, les souris invalidées pour le gène Icos ou IcosL sont protégées du diabète. Nous avons démontré que cette protection est liée à un défaut d’activation des LT diabétogènes. De façon inattendue, nous avons observé chez ces souris ICOS-/- et ICOSL-/- une neuromyopathie. Cette pathologie se développe parallèlement au diabète chez la souris ICOSL+/+. Sur le plan histologique, le muscle strié périphérique et le nerf périphérique est envahi par un infiltrat lymphocytaire et par des cellules présentatrices d’antigène. Nous avons démontré par des expériences de transfert adoptif que la neuromyopathie est une maladie auto-immune données, nous avons étudié les souris NOD ICOSL-/- CIITA-/-. Ces souris sont dépourvues de lymphocytes T -CD4+ et ne développent pas de neuromyopathie ni de diabète. De même, nous avons étudié les souris NOD ICOSL-/- béta2m-/-. Ces souris sont dépourvues de lymphocytes T-CD8+ et développent une neuromyopathie. Cette déviation de l’auto-immunité est liée à l’interaction entre les LT et les lymphocytes B via le signal ICOS/ICOSL. Nous avons prouvé via des expériences de transfert et de chimères que l’absence de signal ICOS/ICOSL entre les lymphocytes T et les lymphocytes B oriente l’auto-immunité vers le système nerveux périphérique et le muscle strié. Enfin, l’analyse du spectre de spécificité des anticorps présent chez la souris ICOSL-/- par western blot puis par spectrométrie de masse a précisé les cibles antigéniques de la myopathie. L’invalidation de la voie ICOS/ICOSL conduit donc à une déviation de l’auto-immunité du pancréas vers le muscle et le système nerveux périphérique. Ces données prouvent que la voie ICOS/ICOSL est indispensable à l’initiation du diabète, mais aussi au contrôle de l’auto-immunité
Costimulation pathways are described as central in T cell activation and the control of autoimmune responses. We previously reported that NOD mice that are deficient for the icosl gene are protected from diabetes, but instead develop a spontaneous autoimmune neuromyopathy. The general phenotype of the neuromyopathy observed in ICOSL-/- NOD mice is globally similar to that observed in ICOS-/- and ICOS-/-ICOSL-/- double knockout NOD mice. The neuromyopathy is observed in 100% of female mice by the age of 35 weeks. The neuropathy remains limited to the peripheral nerve tissue. The disease is characterized by an infiltration of immune cells: CD4+ T cells, CD8+ T cells, dendritic cells and B lymphocytes, but does not extend to the central nervous system. A similar infiltrate is seen in muscles. Autoimmune neuromyopathy can be transfer to naive recipients by T lymphocytes. Transfer is achieved in NOD.scid recipient mice by CD4+ T-cells, although not by CD8+ T-cells, isolated from 35 week old ICOSL-/- NOD. The predominant role of CD4+T-cells is further demonstrated in this model by the observation that CIITA-/-ICOSL-/- NOD mice do not developed the neuromyopathy. By contrast, ȕ2m-/-ICOSL-/- NOD mice develop a neuromyopathy. We obtained evidence (in chimeric mice) that the interaction between antigen-presenting cells (APC) and T lymphocytes via ICOS/ICOSL is a prerequisite to the development of diabetes, while the loss of the interaction between T lymphocytes and APC play a key role in the development of nervous and muscular autoimmunity. Finally, the spectrum analysis of antibodies specificity in mouse ICOSL-/- with Western blot and mass spectrometry indicated the antigenic targets of myopathy. Altogether, our data indicate that the deviation of autoimmunity in NOD mice from the pancreas to muscles and the peripheral nervous system in the absence of ICOS/ICOSL signal is dependent on the loss of the physiological interaction between T cells and APC
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Briet, Claire. "Déviation de l'auto-immunité chez la souris NOD invalidée pour la voie ICOS/ICOSL". Phd thesis, Université René Descartes - Paris V, 2012. http://tel.archives-ouvertes.fr/tel-00849968.

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Le modèle murin le plus utilisé pour le diabète de type 1 est la souris NOD. L'activation des lymphocytes T autoréactifs vis à vis des cellules béta nécessite la reconnaissance par le TCR de l'auto antigène présenté par le CMH ainsi que des signaux de co stimulation. Nous apportons la preuve que la voie de costimulation ICOS/ICOSL est indispensable au développement du diabète chez la souris NOD. En effet, les souris invalidées pour le gène Icos ou IcosL sont protégées du diabète. Nous avons démontré que cette protection est liée à un défaut d'activation des LT diabétogènes. De façon inattendue, nous avons observé chez ces souris ICOS-/- et ICOSL-/- une neuromyopathie. Cette pathologie se développe parallèlement au diabète chez la souris ICOSL+/+. Sur le plan histologique, le muscle strié périphérique et le nerf périphérique est envahi par un infiltrat lymphocytaire et par des cellules présentatrices d'antigène. Nous avons démontré par des expériences de transfert adoptif que la neuromyopathie est une maladie auto-immune données, nous avons étudié les souris NOD ICOSL-/- CIITA-/-. Ces souris sont dépourvues de lymphocytes T -CD4+ et ne développent pas de neuromyopathie ni de diabète. De même, nous avons étudié les souris NOD ICOSL-/- béta2m-/-. Ces souris sont dépourvues de lymphocytes T-CD8+ et développent une neuromyopathie. Cette déviation de l'auto-immunité est liée à l'interaction entre les LT et les lymphocytes B via le signal ICOS/ICOSL. Nous avons prouvé via des expériences de transfert et de chimères que l'absence de signal ICOS/ICOSL entre les lymphocytes T et les lymphocytes B oriente l'auto-immunité vers le système nerveux périphérique et le muscle strié. Enfin, l'analyse du spectre de spécificité des anticorps présent chez la souris ICOSL-/- par western blot puis par spectrométrie de masse a précisé les cibles antigéniques de la myopathie. L'invalidation de la voie ICOS/ICOSL conduit donc à une déviation de l'auto-immunité du pancréas vers le muscle et le système nerveux périphérique. Ces données prouvent que la voie ICOS/ICOSL est indispensable à l'initiation du diabète, mais aussi au contrôle de l'auto-immunité
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Książki na temat "ICOLL"

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Singh, Kehar, A. K. Gupta, Sudhir Khare, Nimish Dixit i Kamal Pant, red. ICOL-2019. Singapore: Springer Singapore, 2021. http://dx.doi.org/10.1007/978-981-15-9259-1.

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UMIST), ICALL Workshop (1991. Proceedings of the ICALL Workshop, UMIST, September 1991. Hull: CTI Centre for Modern Languages, University of Hull, 1992.

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House of mirrors: Performing autobiograph(icall)y in language/education. New York: P. Lang, 2001.

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Kelantan) International Colloquium on Language Teaching (2012 Kota Bharu. International Colloquium on Language Teaching, ICoLT 2012: Enhancing competencies of language practitioners. [Kota Bharu, Kelantan]: Universiti Malaysia Kelantan, 2012.

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Leo, Hollberg, Bergquist James Charles i Kasevich Mark A, red. Proceedings of the XVIII International Conference: ICOLS 2007 : Telluride, Colorado, USA, 24-29 June 2007. Singapore: World Scientific, 2008.

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Germany) International Conference on Laser Spectroscopy (20th 2011 Schlosshotel Münchhausen. Proceedings of the 20th International Conference Laser Spectroscopy: ICOLS 2011, Hannover, Germany, May 30th-June 3rd. Redaktorzy Ertmer Wolfgang i Scholz Rüdiger. Berlin: Logos, 2011.

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Śāstrī, Sītārāma, Jeviyara Kujūra i Jeviyara Hamasāya. Saṃyukta Rāshṭra Ādivāsī Jana Adhikāra Ghoshaṇā kā praśikshaṇa mainyuala: Ādivāsī sāmudāyika saṅgaṭhanakartāoṃ aura netāoṃ ke lie praśikshaṇa (ICOLT). Rān̐cī: Bindarāi Iṃsṭiṭyuṭa phôra Risarca, Ṣṭadī, eṇḍa Ekśana, 2009.

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Rub´en Manzanilla L´opez. Cuetlajuchitlan, sitio preurbano en Guerrero: Un ejemplo de una sociedad jer´arquica agr´icola en la regi´o. M´exico, D.F: Euroamericanas Ediciones, 2006.

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Workshop, Financing and Private Sector Participation in Water Resources Projects (1998 New Delhi, India). Workshop, Financing and Private Sector Participation in Water Resources Projects: Proceedings, 6th November 1998, New Delhi, India : ICOLD 66th annual meeting (part B). Redaktorzy Varma C. V. J, Visvanathan N. hydrologist, Rao A. R. G, Indian Committee on Large Dams. i International Commission on Large Dams. Meeting. Rotterdam: A.A. Balkema, 1999.

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L, Berga, i International Commission on Large Dams. Spanish Committee on Large Dams, red. Dams and reservoirs, societies and environment in the 21st century: Proceedings of the International Symposium on Dams in the Societies of the 21st Century, ICOLD-SPANCOLD, 18 June 2006, Barcelona, Spain. London: Taylor & Francis, 2006.

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Części książek na temat "ICOLL"

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Wu, Ruey-Shyang, Shyan-Ming Yuan, Anderson Liang i Daphne Chyan. "iCell: Integration Unit in Enterprise Cooperative Environment". W Grid and Cooperative Computing, 962–69. Berlin, Heidelberg: Springer Berlin Heidelberg, 2004. http://dx.doi.org/10.1007/978-3-540-24680-0_151.

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Sriram, Sujata, Aparna Joshi i Paras Sharma. "Telephone Counselling in India: Lessons from iCALL". W Counselling in India, 201–16. Singapore: Springer Singapore, 2016. http://dx.doi.org/10.1007/978-981-10-0584-8_11.

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Tournier, Jean-Pierre. "Update on ICOLD Embankment Dam Technical Committee Works". W Dam Breach Modelling and Risk Disposal, 47–55. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-46351-9_5.

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Reuer, Veit, i Kai-Uwe Kühnberger. "Feature Constraint Logic and Error Detection in ICALL Systems". W Logical Aspects of Computational Linguistics, 255–70. Berlin, Heidelberg: Springer Berlin Heidelberg, 2005. http://dx.doi.org/10.1007/11422532_17.

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Heift, Trude. "History and Key Developments in Intelligent Computer-Assisted Language Learning (ICALL)". W Language, Education and Technology, 289–300. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-02237-6_23.

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BRIDLE, RODNEY, JEAN-JACQUES FRY i ALAN J. BROWN JACOBS. "Internal Erosion at Existing Dams: an Outline of a Proposed ICOLD Bulletin". W Managing dams Challenges in a time of change, 100–111. London: Thomas Telford Ltd, 2010. http://dx.doi.org/10.1680/mdctc.40991.0009.

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Simonyi, I., i I. Kékesy. "HPLC of Chloramphen Icol and Some of its Synthetic Intermediates on a Cyclo Dextrin-BonDed Chiral Stationary Phase". W Proceedings of the Fourth International Symposium on Cyclodextrins, 473–77. Dordrecht: Springer Netherlands, 1988. http://dx.doi.org/10.1007/978-94-009-2637-0_66.

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"The Role of ICOLD". W Position Paper Dam Safety and Earthquakes (2017–2020), 8. CRC Press, 2021. http://dx.doi.org/10.1201/9781351035941-8.

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Müller-Wiegand, Matthias, Sven Müller, Sabrina Schmid i Silvia Stiehm. "Quality Function Deployment am Beispiel iCall". W Fallstudien zur Unternehmensführung, 481–97. Vahlen, 2012. http://dx.doi.org/10.15358/9783800645299_481.

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Schauner, Nathalie. "Barrages Voûtes en BCR". W Icold Committee on Concrete Dams, 382–418. CRC Press, 2020. http://dx.doi.org/10.1201/9780429329012-10.

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Streszczenia konferencji na temat "ICOLL"

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Mardani, Neda, Kabir Suara, Mohammadreza Khanarmuei, Richard Brown, Adrian McCallum i Roy Sidle. "A numerical investigation of dynamics of a shallow intermittently closed and open lake and lagoon (ICOLL)". W 22nd Australasian Fluid Mechanics Conference AFMC2020. Brisbane, Australia: The University of Queensland, 2020. http://dx.doi.org/10.14264/7847a45.

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Degraeuwe, Jasper, i Patrick Goethals. "Interactive Word Sense Disambiguation in Foreign Language Learning". W 11th Workshop on Natural Language Processing for Computer-Assisted Language Learning (NLP4CALL 2022). Linköping University Electronic Press, 2022. http://dx.doi.org/10.3384/ecp190005.

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“Word sense awareness” is a feature which is not yet implemented in most corpus query tools, Intelligent Computer-Assisted Language Learning (ICALL) environments or computer-readable didactic resources such as graded word lists (Alfter and Graën, 2019; Pilán et al., 2016; Tack et al., 2018). The present paper aims to contribute to filling this lacuna by presenting a word sense disambiguation (WSD) method for ICALL purposes. The method, which is targeted at Spanish as a foreign language (SFL), takes a few prototypical example sentences as input, converts these sentences into “sense vectors”, and integrates part of the training data collection process into interactive vocabulary exercises. The evaluation of the method is based on a selection of 50 ambiguous items related to the domain of economics and compares different types of input data. With a top weighted F1 score of 0.8836, the present study shows that the currently available NLP tools, resources and methods provide all the necessary building blocks for developing a WSD method which can be integrated into interactive ICALL environments.
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Dickinson, Markus, i Joshua Herring. "Developing online ICALL exercises for Russian". W the Third Workshop. Morristown, NJ, USA: Association for Computational Linguistics, 2008. http://dx.doi.org/10.3115/1631836.1631837.

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Han, Han, Binbin Zhu, Luyao Zhan, Tiantian Yu, Gangwei Shen i Ying Chen. "ICool: One-stop service IoT cloud platform". W 2021 2nd International Conference on Artificial Intelligence and Computer Engineering (ICAICE). IEEE, 2021. http://dx.doi.org/10.1109/icaice54393.2021.00133.

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Demir, S. S. "Simulation-Based Training In Electrophysiology By iCELL". W 2005 IEEE Engineering in Medicine and Biology 27th Annual Conference. IEEE, 2005. http://dx.doi.org/10.1109/iembs.2005.1616549.

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Rickel, E., L. Evans, R. Swanson, SS Levin, M. Rixon, M. Wolfson, J. Bhandari i in. "Abstract P1-09-10: ICOSL anti-HER2 V-mAbs: Localizing engineered ICOSL costimulatory agonists to HER2+ tumors through trastuzumab". W Abstracts: 2017 San Antonio Breast Cancer Symposium; December 5-9, 2017; San Antonio, Texas. American Association for Cancer Research, 2018. http://dx.doi.org/10.1158/1538-7445.sabcs17-p1-09-10.

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Pijetlovic, Dijana, i Elena Volodina. "Developing Swedish Spelling Exercises on the ICALL Platform Lärka". W EUROCALL 2013. Research-publishing.net, 2013. http://dx.doi.org/10.14705/rpnet.2013.000163.

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Bjelkevik, Annika. "ICOLD – sustainable design and post-closure performance of tailings dams". W Sixth International Conference on Mine Closure. Australian Centre for Geomechanics, Perth, 2011. http://dx.doi.org/10.36487/acg_rep/1152_37_bjelkevik.

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Bridle, Rodney. "Internal Erosion Mechanics and Risk Estimation Based on ICOLD Bulletin 164". W Geo-Risk 2017. Reston, VA: American Society of Civil Engineers, 2017. http://dx.doi.org/10.1061/9780784480724.013.

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Frölich, Damian, i L. Thomas van Binsbergen. "iCoLa: A Compositional Meta-language with Support for Incremental Language Development". W SLE '22: 15th ACM SIGPLAN International Conference on Software Language Engineering. New York, NY, USA: ACM, 2022. http://dx.doi.org/10.1145/3567512.3567529.

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