Rozprawy doktorskie na temat „Hypothalamic hormones”
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Tam, Sau-ping. "Gene expression of hypothalamic somatostatin, growth hormone releasing factor, and their pituitary receptors in hypothyroidism /". Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17538865.
Pełny tekst źródła譚秀萍 i Sau-ping Tam. "Gene expression of hypothalamic somatostatin, growth hormone releasingfactor, and their pituitary receptors in hypothyroidism". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31213637.
Pełny tekst źródłaDromey, Jasmin Rachel. "Elucidating novel aspects of hypothalamic releasing hormone receptor regulation". University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0133.
Pełny tekst źródłaLadyman, Sharon Rachel, i n/a. "Characterisation of hypothalamic leptin resistance during pregnancy in the rat". University of Otago. Department of Pharmacology & Toxicology, 2006. http://adt.otago.ac.nz./public/adt-NZDU20070427.154329.
Pełny tekst źródłaInnala, Leyla. "Organizational effects of gonadal hormones on the hypothalamic-pituitary-adrenal axis and glucocorticoid receptor responses in male and female rats". Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/58874.
Pełny tekst źródłaMedicine, Faculty of
Graduate
Solomon, Matia B. "The Effect of Gonadal Hormones on Agonistic Behavior in Previously Defeated Female and Male Syrian Hamsters". Digital Archive @ GSU, 2006. http://digitalarchive.gsu.edu/psych_diss/13.
Pełny tekst źródłaJean, Arnaud. "Plasticité moléculaire de l'aire pré-optique médiane de l'hypothalamus induite par l'expérience sexuelle chez la souris mâle". Thesis, Paris 6, 2017. http://www.theses.fr/2017PA066109/document.
Pełny tekst źródłaSexually experimented males exhibit long term modifications of the dendritic arborization, epigenetic modifications and increased levels of microglia and glutamate associated protein within the hypothalamic medial preoptic area (mPOA). However, hypothalamic and plasmatic concentration of steroid hormones and the nitrergic system are not impacted, contrary to data obtained in rat.The involvement of the ERK1/2 signaling pathway in the induction of sexual experience has also been studied. We showed that ERK1/2 pathway was activated within the mPOA during mating. This activation was increased in sexually experienced males. Furthermore, we showed ex vivo on hypothalamic slices that sex steroids were capable of rapidly (30 min) activate this pathway. Finally, the inhibition of ERK1/2 phosphorylation before the first mating did not disrupt the induction of sexual experience but decreased sexual motivation in a reversible manner.Taken together, these results indicate that long lasting and transitory plasticity mechanisms leading to sexual experience are different between rat and mouse. This indicate the necessity to elaborate a new molecular model associated with the behavioral improvement induced by sexual experience in male mouse
Darzy, Ken H. K. "Pharmacological and physiological studies of anterior·pituitary hormones secretion (GH, ACTH and TSH) in cranially irradiated adult cancer survivors with radiation-induced hypothalamic- pituitary dysfunction". Thesis, University of Manchester, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490184.
Pełny tekst źródłaChristian, Mark. "Investigation of the influence of sex steroid hormones and potential endocrine disrupting chemicals on developing rat hypothalamic dopaminergic neurones in vitro and in vivo". Thesis, Imperial College London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327047.
Pełny tekst źródłaBrischoux, Frédéric. "Etude ontogénétique du système à hormone de mélano-concentration (MCH) chez le rat et régionalisation de l'hypothalamus". Besançon, 2002. http://www.theses.fr/2002BESA0006.
Pełny tekst źródłaKumarnsit, Ekkasit. "Hypothalamic actions of growth hormone secretagogues". Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/24795.
Pełny tekst źródłaOsterstock, Guillaume. "Hypothalamic defaults after traumatic brain injury". Thesis, Montpellier 1, 2012. http://www.theses.fr/2012MON1T017/document.
Pełny tekst źródłaThe works of this thesis were interested in the control of the hypothalamic GHRH neurons in physiological and pathological conditions. The goal was to clarify the molecular and cellular mechanisms involved in the control or impairments of GHR neuronal network functions. These neurons are the main stimulators of the GH release. We first showed that the hypothalamic growth axis could be regulated independently from the feeding network. Indeed, GHRH neurons are directly stimulated by ghrelin, which is the only hormone produced by the gastrointestinal tract known to stimulate the GH release through acting mainly on GHRH neurons. These effects are independent from its orexigenic effects exerted on the neighbourings NPY neurons. In addition, ghrelin and GHS (synthetic ghrelin receptor agonists) don’t change neither the firing rate of GHRH neurons, nor synchronize them. These effects are not gender-dependant; by contrast, Somatostatin, the major GH axis inhibitor, generates a sexual dimorphic and rhythmic inhibition of the GHRH neurons electrical activity mediated by its SST1 and SST2 receptors subtypes. These effects are so time-dependant direct and indirect effects and can probably be involved in the generation of the ultradian rhythm of the GH release. After a traumatic brain injury, we found an early and sustained deficiency of the GH release, like those observed in human. No pathological changes are visible in the pituitary gland. Inflammation occurs at the arcuate nucleus, and mainly at the median eminence levels; it involves a strong astrocyte reaction, tanycytes, and microglial and (or) infiltrated immune cells activations. These changes elicit morpho-functional impairments of the median eminence, permeability and leakage of the tanycyte barrier between the blood, CSF and Arc; at the opposite, nothing occur at the periventricular level, where are located SST neurons. Neither the number of GHRH neurons, neither their passive electrophysiological properties changed. Impairments of the activities of the GHRH nerve terminals, maybe associated to impairments of their regulated activity, must explain a GH deficiency
Danzer, Steven Craig 1970. "Steroid hormone regulation of neurons in the hypothalamic arcuate nucleus". Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282605.
Pełny tekst źródłaMachado, Carla de Moraes. "Alterações na expressão do Hormônio Concentrador de Melanina (MCH) na área hipotalâmica lateral do rato ao longo do desenvolvimento pós-natal e envelhecimento /". Botucatu, 2015. http://hdl.handle.net/11449/128083.
Pełny tekst źródłaCoorientador: Jackson Cioni Bittencourt
Banca: Luiz Fernando Takase
Banca: Luciana Pinato
Resumo: O hormônio concentrador de melanina (MCH) do rato é um nonadecapeptídeo presente em neurônios localizados, principalmente, na área hipotalâmica lateral (LHA) que se projetam para diversas regiões do neuro-eixo. O MCH está envolvido em diversas funções, tais como: reprodução, certos aspectos do comportamento motivado, atividade locomotora, percepção sensorial, controle de temperatura, memória, aprendizagem, ansiedade, ciclo sono-vigília e comportamento alimentar. Nesse, o MCH atua como neuropeptídeo orexígeno. Durante o envelhecimento, ocorre a diminuição no consumo de energia associada à idade. Nesse trabalho, analisamos em diferentes faixas etárias, as variações da expressão do MCH na área hipotalâmica lateral, empregando métodos esterológicos (para estimar o número de neurônios MCH-ir, área, volume e densidade neuronal), reconstrução tridimensional (para estudo da distribuição dos neurônios MCH-ir) e densitometria óptica de tecido hibridizado para reconhecimento do RNAm do ppMCH (para mensuração da área hibridizada, densidade óptica média e densidade óptica integrada [DOI]) na LHA e em suas regiões. Foram utilizados 35 ratos Sprague-Dawley machos, divididos em 7 grupos experimentais de diferentes idades: 14 (lactente), 28 (pré-púbere), 50 (púbere), 90 (adulto jovem), 210 (adulto maduro), 540 (adulto senescente) e 750 (adulto senil) dias pós-natais. Os animais foram submetidos à perfusão transcardíaca, seus encéfalos coletados e processados para análise da expressão do MCH na área hipotalâmica lateral, segundo protocolos de imuno-histoquímica e hibridização in situ. A LHA apresentou um aumento significativo no número de neurônios apenas entre os grupos de 14 e 28 dias e sua área e volume foram significativamente menores apenas no grupo de 14 dias em relação a todos os grupos, com exceção do grupo de 750 dias. No entanto, com relação a densidade neuronal não foram observadas...
Abstract: The Melanin-Concentrating Hormone (MCH) is a nonadecapeptide located mainly in neurons in the lateral hypothalamic area (LHA), which innervate several regions of neuraxis. MCH is involved in many functions as reproduction, aspects of motived behaviors, motor activity, sensorial information, temperature control, memory, learning, anxiety, sleep-wake cycle and feeding behavior in which the MCH plays an orexigenic role. The energy consumption in aging is reduced as well as, the expression of MCH presents alterations associated with age. Therefore, we analyzed the variations in the expression of MCH at different ages in the lateral hypothalamic area, using stereology (to estimate the number of MCH-ir neurons, area, volume and neuronal density), 3D reconstruction (to study the distribution of MCH-ir neurons) and optical density after in situ hybridization protocol for ppMCH RNAm (to measure the hibridizated area, the mean optical density and the integrated optical density [IOD]) in the LHA and its three regions. In this study, 35 animals were divided in 7 experimental groups of 14 (neonate), 28 (prepubescent), 50 (pubescent), 90 (young adult), 210 (middle aged adult), 540 (senescent adult) and 750 (elderly adult) postnatal days. All the animals were perfused via the ascending aorta, the brains were collected and processed by immunohistochemistry and in situ hybridization protocols to analyze the expression of MCH in the lateral hypothalamic area. LHA neurons number increased only between groups of 14 and 28 days, and its area and volume significantly smaller in 14-days group when in respect to all other groups but the 750-days one. However, there weren't differences in neuronal density among groups. MCH-ir neurons distribution in LHA and contiguous regions was similar among all groups as well. Hypothalamic MCH-ir neurons has shown uniform rates in and out of LHA, but after analyzing its distribution in mamillary, tuberal and anterior ...
Mestre
Machado, Carla de Moraes [UNESP]. "Alterações na expressão do Hormônio Concentrador de Melanina (MCH) na área hipotalâmica lateral do rato ao longo do desenvolvimento pós-natal e envelhecimento". Universidade Estadual Paulista (UNESP), 2015. http://hdl.handle.net/11449/128083.
Pełny tekst źródłaFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
O hormônio concentrador de melanina (MCH) do rato é um nonadecapeptídeo presente em neurônios localizados, principalmente, na área hipotalâmica lateral (LHA) que se projetam para diversas regiões do neuro-eixo. O MCH está envolvido em diversas funções, tais como: reprodução, certos aspectos do comportamento motivado, atividade locomotora, percepção sensorial, controle de temperatura, memória, aprendizagem, ansiedade, ciclo sono-vigília e comportamento alimentar. Nesse, o MCH atua como neuropeptídeo orexígeno. Durante o envelhecimento, ocorre a diminuição no consumo de energia associada à idade. Nesse trabalho, analisamos em diferentes faixas etárias, as variações da expressão do MCH na área hipotalâmica lateral, empregando métodos esterológicos (para estimar o número de neurônios MCH-ir, área, volume e densidade neuronal), reconstrução tridimensional (para estudo da distribuição dos neurônios MCH-ir) e densitometria óptica de tecido hibridizado para reconhecimento do RNAm do ppMCH (para mensuração da área hibridizada, densidade óptica média e densidade óptica integrada [DOI]) na LHA e em suas regiões. Foram utilizados 35 ratos Sprague-Dawley machos, divididos em 7 grupos experimentais de diferentes idades: 14 (lactente), 28 (pré-púbere), 50 (púbere), 90 (adulto jovem), 210 (adulto maduro), 540 (adulto senescente) e 750 (adulto senil) dias pós-natais. Os animais foram submetidos à perfusão transcardíaca, seus encéfalos coletados e processados para análise da expressão do MCH na área hipotalâmica lateral, segundo protocolos de imuno-histoquímica e hibridização in situ. A LHA apresentou um aumento significativo no número de neurônios apenas entre os grupos de 14 e 28 dias e sua área e volume foram significativamente menores apenas no grupo de 14 dias em relação a todos os grupos, com exceção do grupo de 750 dias. No entanto, com relação a densidade neuronal não foram observadas...
The Melanin-Concentrating Hormone (MCH) is a nonadecapeptide located mainly in neurons in the lateral hypothalamic area (LHA), which innervate several regions of neuraxis. MCH is involved in many functions as reproduction, aspects of motived behaviors, motor activity, sensorial information, temperature control, memory, learning, anxiety, sleep-wake cycle and feeding behavior in which the MCH plays an orexigenic role. The energy consumption in aging is reduced as well as, the expression of MCH presents alterations associated with age. Therefore, we analyzed the variations in the expression of MCH at different ages in the lateral hypothalamic area, using stereology (to estimate the number of MCH-ir neurons, area, volume and neuronal density), 3D reconstruction (to study the distribution of MCH-ir neurons) and optical density after in situ hybridization protocol for ppMCH RNAm (to measure the hibridizated area, the mean optical density and the integrated optical density [IOD]) in the LHA and its three regions. In this study, 35 animals were divided in 7 experimental groups of 14 (neonate), 28 (prepubescent), 50 (pubescent), 90 (young adult), 210 (middle aged adult), 540 (senescent adult) and 750 (elderly adult) postnatal days. All the animals were perfused via the ascending aorta, the brains were collected and processed by immunohistochemistry and in situ hybridization protocols to analyze the expression of MCH in the lateral hypothalamic area. LHA neurons number increased only between groups of 14 and 28 days, and its area and volume significantly smaller in 14-days group when in respect to all other groups but the 750-days one. However, there weren't differences in neuronal density among groups. MCH-ir neurons distribution in LHA and contiguous regions was similar among all groups as well. Hypothalamic MCH-ir neurons has shown uniform rates in and out of LHA, but after analyzing its distribution in mamillary, tuberal and anterior ...
FAPESP: 2013/08618-3
Miller, Robert. "Approaches to the parametric modeling of hormone concentrations". Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2013. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-118882.
Pełny tekst źródłaBaines, Elizabeth. "Photoperiodic control of hypothalamic gonadotrophin releasing hormone mRNA in Japanese quail". Thesis, University of Edinburgh, 2001. http://hdl.handle.net/1842/10704.
Pełny tekst źródłaBueno, Débora Nunes Martins. "Estudo das conexões da área incerto-hipotalâmica relacionadas ao controle neuroendócrino". Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/42/42131/tde-03062014-164739/.
Pełny tekst źródłaThe incerto-hypothalamic area (IHy) is a diencephalic region poorly studied which is characterized by two non-colocalized neurochemical groups composed by the A13 dopaminergic group intermingled with predominantly GABAergic cells co-expressing melanin-concentrating hormone (MCH) and/or cocaine and amphetamine regulated transcript (CART). Functional studies suggest that IHy is involved in the neuroendocrine control of female reproduction in specific metabolic states mediated by MCH. In this way, our aim is to study the IHy connections in female rats related to neuroendocrine control of female reproduction using neuronal anterograde Biotin Dextran Amine (BDA) and retrograde Flurogold (FG) tracers. As a result, we found that IHy projections are the lateral septal nucleus, bed nucleus of stria terminalis, paraventricular thalamic nucleus, reuniens thalamic nucleus, medial preoptic area, medial and lateral preoptic nucleus, median preoptic nucleus, periventricular hypothalamic nucleus, anteroventral periventricular nucleus, anterior, posterior and lateral hypothalamic area and precommissural nucleus. The main afferents to the IHy, in females, are the lateral septal nucleus, median preoptic nucleus and paraventricular thalamic nucleus. These results suggest sexually dimorphic projections from the IHy, since IHy more densely innervates neuroendocrine regions in female than in male rats.
Pithey, Anne Louise. "Autocrine regulation of gonadotropin-releasing hormone in immortalized hypothalamic GT1-7 neurons". Master's thesis, University of Cape Town, 1994. http://hdl.handle.net/11427/27030.
Pełny tekst źródłaBronner, Sandra. "Le système ocytocinergique hypothalamo-spinal : étude anatomique et fonctionnelle". Université Louis Pasteur (Strasbourg) (1971-2008), 2004. http://www.theses.fr/2004STR13077.
Pełny tekst źródłaBesides its classical hormonal actions, the neurohypophyseal peptide oxytocin (OT) exerts neurotransmitter and/or neuromodulator actions in many regions of the central nervous system, including the spinal cord. Application of autoradiographic techniques either on films (macroscopic detection) or on liquid emulsion covered slides (detection at cellular scale) allows the precise study of OT binding sites localisation in the spinal cord during postnatal development. They are expressed in sensory (laminae I and II, lateral spinal nucleus) and autonomous regions (lamina X, intermediolateral columns, sacral parasympathetic nucleus). OT binding sites in sensory regions are already present at birth, whereas those of autonomous regions appear only during the first postnatal weeks of life. A transient expression of OT binding sites occurs in the dorsal nucleus and on motoneurones of the ventral horns during the first two weeks of life. Density of OT binding sites in the laminae I and II varies significantly during the first three weeks of life, presenting a maximum at day 14. Experimental modifications of the sexual steroids level have no significant effect on OT binding sites expression in the spinal cord. Immunocytochemical detection of oxytocinergic fibres reveals their presence in regions expressing OT binding sites. Anterograde tract tracing after biotin dextran amine injection in the paraventricular nucleus of the hypothalamus (NPV) followed by single fibres reconstruction clearly shows that some parvocellular neurones project at the same time in sensory and autonomous regions of the lumbosacral spinal cord. An electrical stimulation of the NPV leads to an increase in the expression of c-Fos protein in the dorsal horns. The c-Fos expressing neurones after NPV stimulation are in close vicinity with oxytocinergic fibres. These results comfort the existence of an oxytocinergic control of autonomous and nociceptive centres in the spinal cord via the paraventriculospinal tract
Harbuz, M. S. "Hypothalamic catecholamines in the regulation of LH secretion in the domestic fowl (Gallus domesticus)". Thesis, University of Reading, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.382172.
Pełny tekst źródłaMacGregor, Duncan James. "Modelling hypothalamic control of growth hormone release and spike firing in oxytocin cells". Thesis, University of Edinburgh, 2003. http://hdl.handle.net/1842/23104.
Pełny tekst źródłaToppila, Jussi. "Somatostatin, growth hormone-releasing hormone, galanin and their hypothalamic messenger ribonucleic acids in the regulation of sleep in rats". Helsinki : University of Helsinki, 1999. http://ethesis.helsinki.fi/julkaisut/laa/biola/vk/toppila/.
Pełny tekst źródłaGulikers, Keven Peter. "Evaluation of the effects of clomipramine on the canine hypothalamic-pituitary-thyroid axis". Thesis, Virginia Tech, 2002. http://hdl.handle.net/10919/31768.
Pełny tekst źródła
The results of this study indicate that significant and substantial decreases in T4 (35%), fT4 (38%), and rT3 can occur during clomipramine administration. Long-term administration of clomipramine may result in a misdiagnosis of hypothyroidism if a dog is tested while taking this medication and, since decreased serum fT4 occurs, hypothyroidism may result.
Master of Science
DiBenedetto, Lynn M. "An Examination of the Hypothalamo-neurohypophysial System of the Rat: Restoration of the Vasopressinergic System". eScholarship@UMMS, 1997. https://escholarship.umassmed.edu/gsbs_diss/169.
Pełny tekst źródłaAtallah-Ibrahim, Afnan. "Effects of sex steroid hormones on the neurovascular unit in the mouse hypothalamus". Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066199/document.
Pełny tekst źródłaFunctional integrity of the blood-brain barrier (BBB) is compromised in many neurological and metabolic pathologies. Cerebral blood vessels are target tissue for sex steroid hormones but the relative contribution of these endocrine effectors and their receptors in the BBB integrity are still unclear. Effects of gonadal hormones on the mouse neurovascular unit were studied, focusing on the hypothalamic medial preoptic area, a highly sensitive brain area to gonadal steroid hormones. BBB permeability increased in both gonactectomized male and female, is associated with tight junction disorganization and lower expression of tight junction proteins, glial activation, and up-regulation of inflammatory molecules in male. Testosterone supplementation restores the BBB impermeability, tight junction integrity, and almost completely abrogated the inflammatory features. Androgen and estrogen receptor may be involved in testosterone-induced regulation of the formation and maintenance of tight junction in males. Studying the involvement of these receptors using a trans-genic mice line selectively lacking neural AR in the CNS, highlighted the negative effect of this dele-tion on the BBB and TJ integrity. To complete, ex vivo slices of male mouse hypothalamus allowed to assess short-term molecular mechanisms of testosterone on the BBB structure and function.These data raise questions about the potential deleterious effects of endocrine disruptors on the BBB integrity and the occurrence of neurological and metabolic diseases
Nesbitt, Catherine. "Variations in maternal lickinggrooming influences both dam and offspring's hypothalamic-pituitary-adrenal hormone profile". Thesis, McGill University, 2009. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=111562.
Pełny tekst źródłaKey word abbreviation: (1) CORT - CORTicosterone, (2) ACTH - AdrenoCorticoTropin releasing Hormone, (3) CBG - Corticosteroid Binding Globulin, (4) SHRP - Stress Hypo-Responsive Period, (5) P - Post-natal day, (6) HPA - Hypothalamic-Pituitary-Adrenal, (7) LG - Licking/Grooming, (8) ADX/OVX - ADrenalectomized/OVarectomized.
Haynes, Andrea Claire. "Characterisation of orexins and melanin-concentrating hormone in the hypothalamic regulation of food consumption". Thesis, University of Buckingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.250767.
Pełny tekst źródłaBarbotin, Anne-Laure. "Plasticité neuro-structurale de l’hypothalamus dans le syndrome des ovaires polykystiques". Thesis, Lille, 2019. http://www.theses.fr/2019LILUS043.
Pełny tekst źródłaPolycystic ovary syndrome (PCOS) is the most common reproductive disorder (10% of women worldwide). Anti-Müllerian hormone (AMH) levels are found to be 2-3-fold higher in PCOS women than in those with normal ovaries. AMH induces LH secretion by stimulating the activation of GnRH secretion. As recently demonstrated, this increase in GnRH secretion could be related to hyperactivity of GnRH neurons in response to a direct action of AMH but could also be exerted indirectly via an increase in excitatory inputs on GnRH neurons.Our team has previously demonstrated that tanycytes, which unsheathe the terminals of GnRH neurons, regulate GnRH secretion and express AMH receptor. Thus, we aim to determine (1) whether elevated AMH could be responsible for the retraction of the tanycyte coverage leading to increased GnRH/LH secretion in PCOS and (2) whether neuronal hyperactivity in hypothalamus could contribute to higher GnRH activity in PCOS women.Firstly, we have performed ultrastructural studies in rodents’ median eminence (ME) explants challenged with AMH. Then, we compared tanycytic retraction using electron microscopy. We have performed the same experiments in a PCOS mouse model. In humans, we have used metabolic magnetic resonance imaging approaches (i.e. proton magnetic resonance spectra). In order to assess neuronal activity, we have compared N-acetyl-aspartate/creatine ratios in the hypothalamus between PCOS women versus controls.Using electron microscopy, we have shown that tanycytes displayed a significant retraction of their end-feet after AMH treatment ex vivo. This is followed by the sprouting of GnRH terminals towards the pericapillary space. Such processes could significantly favor the sustained delivery of peak levels of GnRH, which could contribute to the rise in LH levels typical of PCOS condition. We have found the same results in PCOS-mouse model with higher GnRH terminals towards the pericapillary space in PCOS mice than in controls. In addition, we found an increase in neuronal activity in the arcuate nucleus of the hypothalamus in PCOS mice. Moreover, this region is particularly involved in the regulation of GnRH secretion. For the first time, we have demonstrated that PCOS women exhibit higher concentrations of GnRH measured by mass spectroscopy than GnRH levels in normo-ovulatory women. Our proton magnetic resonance spectroscopy analysis has revealed that PCOS women exhibit higher N-acetyl aspartate/creatine ratio than controls. These results are predicted to be correlated with increased hypothalamic activity.This translational study suggests that the increase in GnRH / LH secretions found in PCOS could be explained by neurostructural hypothalamic plasticity in link with tanycytes retraction and by an increase of neuronal activity in the hypothalamus
May, Aaron. "Hormonal Influence on Insulin Transport Through the Blood-Brain Barrier and Hypothalamic Inflammation". University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479809275921804.
Pełny tekst źródłaSkorupskaite, Karolina. "Kisspeptin and neurokinin B in the regulation of the human hypothalamic-pituitary-gonadal axis". Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28897.
Pełny tekst źródłaNäsman, Birgitta. "The limbic-hypothalamic-pituitary-adrenal axis in Alzheimer's disease". Doctoral thesis, Umeå universitet, Geriatrik, 1994. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-140822.
Pełny tekst źródładigitalisering@umu
Kennedy, Adam Richard. "The role of melanin-concentrating hormone in the hypothalamus and the pituitary". Thesis, Imperial College London, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.431749.
Pełny tekst źródłaCounsell, John R. "The role of thyroid hormone in the ventromedial nucleus of the hypothalamus". Thesis, Imperial College London, 2011. http://hdl.handle.net/10044/1/9041.
Pełny tekst źródłaBertherat, Jérôme. "Intéractions intrahypothalamiques entre les neurones à somatostatine et à growth hormone-releasing hormone (GHRH) dans le contrôle de l'hormone de croissance (GH) chez le rat". Paris 11, 1992. http://www.theses.fr/1992PA11T011.
Pełny tekst źródłaChu, Yan-shuen Jessica. "Secretin in the rat hypothalamo-pituitary system localization, release mechanisms, and functions /". Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31367781.
Pełny tekst źródłaRichy, Sébastien. "Peptides, hormones et régulation pondérale : impact des conditions nutritionnelles précoces chez le rat". Nancy 1, 2004. http://www.theses.fr/2004NAN10233.
Pełny tekst źródłaWe studied the consequences of nutritional manipulations during gestation on hormones and peptides offsprings status. From half gestation, female rats were fed on an adequate well-balanced diet for two third of their energy needs. They were offered the possibility to complete their energy intake through the ingestion of a diet either rich in carbohydrate (HC group) or in fats (HF) or the well-balanced diet (Cr). A other group (C) was fed ad libitum on the balanced diet. At birth, HC and Cr pups were lighter than C and HF pups. At adult age, Cr rats remained lighter while HC tended to be heavier. HF animals did not have any weight problem. At weaning, NPY and AgRP mRNA expression in the arcuate nucleus was significantly higher in the HC pups. In these rats at adulthood, glucose, insulin and leptin plasma levels were increased. Despite this, NPY and AgRP hypothalamic system was not down-regulated while POMC neurons were. We concluded that a central leptin and insulin resistance could exist in these overweight HC rats
Chautard, Thierry. "Régulation de la fonction corticotrope en période postnatale : effet des glucocorticoi͏̈des et des acides aminés excitateurs". Aix-Marseille 3, 1991. http://www.theses.fr/1991AIX30027.
Pełny tekst źródłaBigeard, Lucienne. "Manifestations bucco-dento-maxillaires des insuffisances staturales d'origine hypothalamo-hypophysaire". Université Louis Pasteur (Strasbourg) (1971-2008), 1990. http://www.theses.fr/1990STR1SO01.
Pełny tekst źródłaChu, Yan-shuen Jessica, i 朱恩璿. "Secretin in the rat hypothalamo-pituitary system: localization, release mechanisms, and functions". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31367781.
Pełny tekst źródłaRossi, Michela. "Investigation of the role of melanin concentrating hormone and the melanocortins in the hypothalamic control of feeding". Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.271074.
Pełny tekst źródłaLESLUYES, MAZZOCCHI LAURENCE. "Controle hypothalamique de la secretion d'hormone de croissance chez le belier". Aix-Marseille 2, 1994. http://www.theses.fr/1994AIX20858.
Pełny tekst źródłaGriffith, Ronald D. "Thyroid hormones are required during long-day photoperiods for the establishment of estradiol-sensitive afferent input to and activation of, dopaminergic neurons in the A15 area of the ovine hypothalamus". Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1580.
Pełny tekst źródłaTitle from document title page. Document formatted into pages; contains viii, 46 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 33-38).
Kelley, Jennifer Caitlin. "Effects of Estrogen and Progesterone on the Sensitivity of the Anterior Pituitary Gland and Hypothalamus in Prepubertal Rats: Role of Nitric Oxide and Dopamine". Miami University Honors Theses / OhioLINK, 2005. http://rave.ohiolink.edu/etdc/view?acc_num=muhonors1114785173.
Pełny tekst źródłaDecherf, Stéphanie. "Répression des gènes hypothalamiques Trh et Mc4r par les hormones thyroïdiennes : << de la régulation transcriptionnelle à l'intégration métabolique >>". Paris 6, 2010. http://www.theses.fr/2010PA066398.
Pełny tekst źródłaKruijver, Franciscus Petrus Maria. "Sex in the brain gender differences in the human hypothalamus and adjacent areas : relationship to transsexualism, sexual orientation, sex hormone receptors and endocrine status /". [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/75961.
Pełny tekst źródłaAllet, Cécile. "Gliogenèse dans l'hypothalamus au cours du développement postnatal : implication dans le contrôle de la maturation sexuelle femelle". Lille 2, 2006. http://www.theses.fr/2006LIL2S051.
Pełny tekst źródłaThe initiation of mammalian puberty requires an increased pulsatile secretion of GnRH from specialized neurons of the hypothalamus controlling sexual development. We have identified newborn cells by injecting BrdU at various intervals thereafter. We report that during sexual maturation a host of new cells is generated in the hypothalamus. This wave of cell neogenesis precedes and accompanies the first gonadal independent GnRH-driven activation of the reproductive axis. By P15 a significant fraction of GnRH neuronal cell bodies is morphologically associated with differentiated cells that were born on P8. Moreover, upto 35% of the cells closely associated with GnRH axon terminals entering cell cycle remain associated with this neurosecretory system once differenciated. These results raise the exciting possibility that birth of new cells is a component of the maturational process required for the activation of GnRH neuronal function at the onset of puberty
Zollner, Ekkehard Werner Arthur. "Hypothalamic-pituitary-adrenal axis suppression in asthmatic children on corticosteroids". Thesis, Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/95468.
Pełny tekst źródłaENGLISH ABSTRACT: Although the effect of inhaled corticosteroids (ICS) on the hypothalamic- pituitary-adrenal axis (HPA) has been regarded as a “benign physiological response”, a survey published in 2002 suggested that adrenal crisis is more common in asthmatic children on ICS than previously thought. Relying on clinical features to detect chronic adrenal insufficiency secondary to corticosteroids may not be wise, as these are non-specific and can therefore easily be missed. Accurate biochemical assessment of the whole axis to detect subclinical HPA suppression (HPAS) is thus desirable. A review of the literature indicates that basal adrenal function tests, including plasma cortisol profiles, do not identify which children can appropriately respond to stress. There is no evidence to suggest that the degree of the physiological adjustment of the HPA to ICS and/or nasal steroids (by reducing basal cortisol production), predicts HPAS. Cortisol profiles should therefore only be used to demonstrate differences in systemic activity of various ICS and delivery devices. Only two tests, considered as gold standard adrenal function tests [the insulin tolerance test (ITT) and the metyrapone test] can assess the integrity of the whole axis.
AFRIKAANSE OPSOMMING: Die outeurs van ´n opname wat in 2002 gepubliseer is stel voor dat ´n bynierkrisis meer algemeen by asmatiese kinders, wat inhalasie kortikosteroïede ontvang, voorkom as wat voorheen gedink is. Dit is strydig met die gevestigde opvatting dat die effek van IKS op die hipotalamiese-hipofise-bynier-as (HHB) ’n “goedaardige fisiologiese reaksie” is. Die kliniese kenmerke van kroniese bynierontoereikendheid sekondêr tot die gebruik van kortikosteroïede (KS) is nie-spesifiek en gevolglik onbetroubaar. ´n Akkurate biochemiese toets van subkliniese HBB onderdrukking (HHBO) sou gevolglik waardevol wees. ´n Literatuur oorsig toon dat toetse van basale bynierfunksie, insluitend plasma kortisol (K) profiele, nie kinders uitken wat toepaslik op stres sal reageer nie. Daar is geen bewyse dat die graad van fisiologiese aanpassing van die HHB, soos aangedui deur laer K-vlakke, na die gebruik van IKS en/of nasale steroïede (NS), HHBO voorspel nie. Serum K profiele is dus slegs van waarde om die sistemiese aktiwiteit van verskillende IKS en toedieningsstelsels te ondersoek. Slegs twee toetse, naamlik die insulien toleransie toets (ITT) en die metyrapone -(MTP)-toets (wat beide as die goue standaard van bynier funksie beskou word), kan die integriteit van die hele as meet.
Stellenbosch University
Medical Research Council
SA Thoracic Society
Harry Crossley Foundation
Red Cross Children’s Hospital.
Jolley, Sandra. "Maternal adaptation from pregnancy to postpartum : focus on the relationship beween the hypothalamic-pituitary-adrenal axis and mood /". Thesis, Connect to this title online; UW restricted, 2004. http://hdl.handle.net/1773/7187.
Pełny tekst źródłaArmstrong, M. E. "Candidate role for nuclear hormone receptors in gene regulation in magnocellular neurones in the hypothalamus". Thesis, University of Cambridge, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.596152.
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