Rozprawy doktorskie na temat „Hypoglycemia”
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Dodd, Will. "Hypoglycemia". Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etsu-works/8922.
Pełny tekst źródłaSchutz, Peter W. "Neuroprotective effects of ketone bodies during hypoglycemia". Thesis, University of British Columbia, 2011. http://hdl.handle.net/2429/34014.
Pełny tekst źródłaEckert, Bodil. "Hypoglycaemia studies on central and peripheral nerve function /". Lund : Dept. of Internal Medicine, University of Lund, 1998. http://catalog.hathitrust.org/api/volumes/oclc/57426099.html.
Pełny tekst źródłaCiraolo, Susan Taylor. "Model of extreme hypoglycemia in the ketotic dog". Case Western Reserve University School of Graduate Studies / OhioLINK, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=case1057250332.
Pełny tekst źródłaMinić, Marina. "Investigation of a syndrome of non insulin-dependent hypoglycaemia and overgrowth". Thesis, University of Cambridge, 2015. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.708929.
Pełny tekst źródłaSami, Sumrin Ramiza. "Islet Transplantation in Type I Diabetes Patients with Hypoglycemia". Thesis, Umeå universitet, Farmakologi, 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-126081.
Pełny tekst źródłaIsom, Amanda M. "The Cellular Consequences of Combining Antipsychotic Medications and Hypoglycemia". University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1407407111.
Pełny tekst źródłaClark, DessyeDee M. "Computer-aided hypoglycemia detection in adolescents with insulin-dependent diabetes mellitus /". Thesis, Connect to this title online; UW restricted, 2001. http://hdl.handle.net/1773/7368.
Pełny tekst źródłaKalergis, Maria. "Prevention of noctural hypoglycemia in adults with type 1 diabetes undergoing intensive management". Thesis, McGill University, 2002. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=19501.
Pełny tekst źródłaLeelarathna, Lalantha Harendra. "Improving glucose control and reducing the burden of hypoglycaemia : use of novel diabetes technology in type 1 diabetes and critical illness". Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648482.
Pełny tekst źródłaSchenk, Sarah E. "Acute and recurrent hypoglycemia modulates brain glycogen metabolism in the mouse". Muncie, Ind. : Ball State University, 2009. http://cardinalscholar.bsu.edu/618.
Pełny tekst źródłaGuelfi, Kym Janese. "Glucoregulatory responses to intermittent high-intensity exercise in individuals with type 1 diabetes mellitus : insight into the risk of hypoglycaemia". University of Western Australia. School of Human Movement and Exercise Science, 2006. http://theses.library.uwa.edu.au/adt-WU2006.0078.
Pełny tekst źródłaDankwa, Joel. "Role of the mineralocorticoid receptor in hypoglycemia-induced inflammation in humans". Thesis, Boston University, 2012. https://hdl.handle.net/2144/12342.
Pełny tekst źródłaHypoglycemia has been implicated in the pathophysiology of cardiovascular disease. Hypoglycemia is also known to increase both inflammatory factors and counterregulatory hormones. Although the mechanism by which hypoglycemia contributes to cardiovascular injury is unclear, it is suspected that elevation of inflammatory factors and counterregulatory hormones are associated with this injury. Several studies have demonstrated a possible role of the mineralocorticoid receptor in hypoglycemia-associated autonomic failure and thus diminished autonomic control of the heart. Furthermore, activation of the mineralocorticoid receptor is pro-inflammatory. Cortisol and aldosterone, both of which are ligands to the mineralocorticoid receptor, are elevated during hypoglycemia. Our aim in conducting this study was to test the hypothesis that blockade of the mineralocorticoid receptor will reduce the pro- inflammatory effects of hypoglycemia-induced inflammation. In a clinical study of 7 healthy men and women, we found that administration of a mineralocorticoid receptor antagonist blunted the elevation of IL-6 during hypoglycemia. Results in this thesis demonstrate that antagonism at the mineralocorticoid receptor may minimize elevation of inflammation via IL-6, and suggest that activity at the mineralocorticoid receptor may be a means to address the effects of hypoglycemia-induced inflammation.
Rubega, Maria. "Quantitative analysis of hypoglycemia-induced EEG alterations in type 1 diabetes". Doctoral thesis, Università degli studi di Padova, 2017. http://hdl.handle.net/11577/3425362.
Pełny tekst źródłaIl principale rischio per i pazienti colpiti dal diabete di tipo 1 (T1D) è cadere in ipoglicemia, un evento che provoca una nutrita serie di sintomi ed effetti a breve e lungo termine e può essere particolarmente pericoloso quando si verifica durante la notte senza averne coscienza. Inoltre, questi pazienti rischiano di sviluppare una forma di ipoglicemia senza sintomi, riducendo la risposta ormonale controregolatoria innescata dalla diminuzione della concentrazione di glucosio nel sangue. Evitare questo stato patologico, è particolarmente importante sia nei bambini e adolescenti per evitare possibili distorsioni cognitive, sia negli adulti dove test cognitivi hanno dimostrato un’alterata condizione cerebrale durante l’ipoglicemia. Infatti l’ipoglicemia provoca una diminuzione delle funzioni cerebrali e l’organo maggiormente affetto da questo stato patologico è il cervello. Si trovano vari studi in letteratura che provano come la riduzione delle funzioni cognitive si rifletta in cambiamenti della potenza spettrale del segnale elettroencefalografico (EEG). In particolare, la crescita della potenza delle basse frequenza nel segnale EEG è un effetto ben noto in letteratura. Studi pilota hanno dimostrato che potrebbe essere possibile utilizzare il segnale EEG per segnalare l’entrata in ipoglicemia. Il maggiore vantaggio è che se la soglia di concentrazione di glucosio nel sangue è variabile da soggetto a soggetto, l’onset dei cambiamenti del segnale EEG avviene solitamente prima che lo stato di ipoglicemia sia così grave da causare una marcata neuroglicopenia con conseguente disfunzione cerebrale. Il principale scopo di questa tesi è approfondire l’analisi delle alterazioni del segnale EEG nel T1D causate dall’ipoglicemia per identificare potenziali margini di miglioramento nell’analisi del segnale EEG e ulteriori caratteristiche sensibili all’ipoglicemia. In particolare, le analisi sono estese a diversi domini, il dominio del tempo e il dominio della frequenza, per approfondire la conoscenza sugli effetti dell’ipoglicemia sul cervello. Fino ad ora, gli studi in letteratura hanno principalmente valutato questi cambiamenti a livello di singolo canale EEG e nel dominio della frequenza, ma una limitata informazione è disponibile sull’influenza dell’ipoglicemia sulla dinamica della rete cerebrale e sulla connessione tra le diverse aree cerebrali. Per affrontare questi temi, la tesi è strutturata in 7 capitoli, brevemente descritti di seguito. Il Capitolo 1 presenta una panoramica sulle conseguenze e sull’impatto nella vita di tutti i giorni del T1D. Inoltre, si descrivono brevemente i risultati sugli effetti dell’ipoglicemia sull’attività cerebrale riportati in letteratura. Il Capitolo 2 riporta il database su cui sono basate tutte le analisi presentate in questa tesi. Il segnale EEG e la concentrazione di glucosio nel sangue sono state raccolte in parallelo per circa 8 ore in 31 pazienti ospedalizzati affetti da T1D indotti in ipoglicemia attraverso un clamp ipoglicemico iperinsulinemico. Il Capitolo 3 tratta degli effetti dell’ipoglicemia sull’EEG nel dominio della frequenza. Dopo aver confermato la presenza di cambiamenti nel valore della potenza del segnale EEG durante l’ipoglicemia, si riporta un’analisi multivariata basata sulla stima della connettività funzionale del segnale EEG durante questo stato patologico. In particolare, confermeremo il rallentamento del segnale EEG nel dominio della frequenza e dimostreremo come lo stato ipoglicemico influenza la connettività funzionale del segnale EEG. Il Capitolo 4 si concentra sugli effetti dell’ipoglicemia sulla complessità del segnale EEG. In particolare, le analisi sono basate su indicatori frattali e sul confronto dei loro valori con i risultati di indicatori basati sulla definizione di entropia. Riveleremo una decrescita della complessità del segnale EEG durante lo stato di ipoglicemia. Il Capitolo 5 tratta le conseguenze dello stato ipoglicemico sui microstati, definiti anche "atomi del pensiero". Ipotizzeremo che i cambiamenti nel dominio della frequenza e la decrescita della complessità del segnale EEG possano essere originati da una stessa mappa delle ampiezze del potenziale elettrico del segnale EEG. Il Capitolo 6 si focalizza sull’influenza dell’ipoglicemia sui risultati di test cognitivi come lo Stroop test. Inoltre, tratta la relazione tra il calo nella performance in questi test e le misure quantitative del segnale EEG presentate nei capitoli precedenti. Troveremo una correlazione diretta tra i cambiamenti della potenza spettrale, dei test cognitivi e di una mappa EEG. Infine, il Capitolo 7 conclude la tesi cercando di interpretare tutti i risultati nel dominio del tempo e della frequenza sia da un punto di vista clinico sia da un punto di vista ingegneristico e presenta i possibili sviluppi futuri.
Frey, Paul, Yong Gu Lee, Holly Paddock, Brian Erstad i Sid Patanwala. "Continuous Intravenous Insulin Weight Based Dose-Related Hypoglycemia in Critically Ill Patients". The University of Arizona, 2014. http://hdl.handle.net/10150/614183.
Pełny tekst źródłaSpecific Aims: To evaluate the association of weight-based insulin dose with hypoglycemia in critically ill patients receiving continuous intravenous insulin infuions. To determine whether higher weight-based doses of insulin were associated with a higher incidence of hypoglycemia Methods: This was a retrospective, case-control study conducted at a tertiary care, academic medical center. Adult (>18 years) patients admitted to the intensive care unit (ICU) receiving intravenous (IV) regular insulin infusions for the management of hyperglycemia between 1 January 2008 and 30 March 2013 were included. Medical records were retrospectively reviewed. Each patient with hypoglycemia was matched with a non-hypoglycemic control subject, based on age range and sex. Laboratory data, patient demographics, hypoglycemic events, insulin infusion data, SOFA scores, length of hospital and ICU stay, and patient outcomes were collected and evaluated. Main Results: Sixty-one patients experienced a hypoglycemic event and were matched with 61 non-hypoglycemic control subjects for statistical analysis. With the exception of ethnicity (p = 0.041) as a demographic predictor of hypoglycemia; age, sex, weight, height, and BMI were not significant. The starting insulin infusion rate and the total number of insulin units per day administered were not found to be associated with hypoglycemia, p=0.107 and p=0.357, respectively. Conclusion: This study failed to show significance in the total units per day of insulin and the incidence of hypoglycemia. There was no statistical significance in BMI between case and control groups, thus no clear conclusion can be made associating hypoglycemia with weight-based insulin dosing.
Piotrowicz, Agata. "Exploring Exercise In Type 1 Diabetes: Intervention With An On-Line Educational Tool". Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/20244.
Pełny tekst źródłaKesselheim, Anne Lore. "Genetic and molecular studies in hyperinsulinemic hypoglycemia and congenital polycystic kidney disease (HIPKD)". Thesis, University College London (University of London), 2018. http://discovery.ucl.ac.uk/10057201/.
Pełny tekst źródłaMoriconi, Diego. "Efficacy of Lisosan G (fermented wheat) on post-prandial hypoglycemia after bariatric surgery". Doctoral thesis, Università di Siena, 2023. https://hdl.handle.net/11365/1227315.
Pełny tekst źródłaCowan, Simone. "Anti-hypertensive drug use and the risk of serious hypoglycemia in patients with diabetes". Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30840.
Pełny tekst źródłaUtilizing the Saskatchewan Health databases, we conducted a case-control study nested within a cohort of 3639 patients with diabetes, newly prescribed angiotensin converting enzyme inhibitors (ACE-I) or dispensed other anti-hypertensive drugs during 1982 to 1987. There were 162 cases of hypoglycemia identified. All potential controls, matched to the case on entry date and at different eligible at-risk times, were selected (n = 8329).
After adjustment for confounders, current users of ACE-I and non-selective beta-blockers had a clinically important increased risk of hypoglycemia, RR 1.61 (95% CI: 0.99--2.60) and RR 1.81 (0.97--3.40), respectively. Current users of ACE-I for a duration of 120 days or greater had a 2-fold increased hypoglycemic risk, RR 2.06 (1.12--3.82).
The use of ACE-I and non-selective beta-blockers may be associated with serious hypoglycemia.
Lam, Fred, i Ali Bokhari. "New Onset Hypoglycemia in Non-diabetic Adult Patients: Where Do We Go from Here?" Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/asrf/2020/presentations/55.
Pełny tekst źródłaDwyer, Trisha A. "Brain Hypometabolism and Seizures: The Dynamics of Hypoxia and Hypoglycemia in Brain Energy Homeostasis". University of Toledo Health Science Campus / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=mco1313737400.
Pełny tekst źródłaShum, Kar Man Kathy. "Effects of antecedent hypoglycemia, antecedent hyperinsulinemia, and antecedent corticosterone on subsequent counterregulation in normal rats". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0021/MQ54188.pdf.
Pełny tekst źródłaKlöckener, Tim [Verfasser], i Jens [Akademischer Betreuer] Brüning. "Insulin regulates Energy Homeostasis and Hypoglycemia in the Ventromedial Hypothalamus / Tim Klöckener. Gutachter: Jens Brüning". Köln : Universitäts- und Stadtbibliothek Köln, 2012. http://d-nb.info/103837989X/34.
Pełny tekst źródłaLiang, Lei [Verfasser]. "Human KCNQ1 mutations cause neonatal diabetes and hyperinsulinemic hypoglycemia : clinical and functional characterization / Lei Liang". Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2016. http://d-nb.info/1119803284/34.
Pełny tekst źródłaChaverneff, Florence. "CK2 Contributes to the Synergistic Effects of BMP7 and BDNF on Smad 1/5/8 Phosphorylation in Septal Neurons". Scholarly Repository, 2008. http://scholarlyrepository.miami.edu/oa_dissertations/352.
Pełny tekst źródłaOberlin, Douglas J. "Neither recurrent hypoglycemia nor chronic aerobic training alter the content of MCTs in the ventromedial hypothalamus". Thesis, The University of North Carolina at Greensboro, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10154649.
Pełny tekst źródłaMany individuals with diabetes use medications or exercise to control blood glucose concentrations, which can lead to episodes of hypoglycemia. Although chronic hyperglycemia leads to many diabetic complications, hypoglycemia is an acute threat to the health of individuals, and can lead to myocardial ischemia and arrhythmias, as well as increasing inflammation, oxidative stress, and thrombotic and fibrinolytic processes. Either antecedent exercise or antecedent hypoglycemia lead to a blunted counter-regulatory response to a subsequent hypoglycemia episode. Acute exercise has been shown to increase monocarboxylate transport proteins (MCTs) in the ventromedial hypothalamus (VMH) of the brain, which is involved in regulating the counter-regulatory response to restore euglycemia. The MCTs shuttle lactate in and out of cells, however when is lactate infused into the VMH has been shown to interfere with the counter-regulatory response. Additionally, antecedent recurrent hypoglycemia has been shown to increase lactate transport in the brain. Therefore, the current studies investigated what effect exercise training or recurrent antecedent hypoglycemia had on MCT proteins in the VMH. Adult male Sprague-Dawley rats were used for both studies, randomized to receive either 6-7 weeks of aerobic training, sedentary behavior, 3 days of insulin induced hypoglycemia, or 3 days of saline injection. The increases in cytochrome c oxidase activity among the aerobically trained group showed that training adaptations occurred, however, there were no significant differences in MCT proteins within the VMH between the trained versus sedentary rats. While each of the 3 days of hypoglycemia or saline injection showed differences in 30 minute post-injection glucose concentrations, no significant differences in MCTs were observed in the VMH between the 2 groups on day 4.
Dobriansky, V. V. "Risk factors for recurrent hypoglycemia in patients with type II diabetes mellitus in the prehospital stage". Thesis, БДМУ, 2022. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/19824.
Pełny tekst źródłaRitrosky, Zulay. "Prevalence of and Risk Factors for Intraoperative Non-Euglycemia Events in Premature Neonates <2500 Grams". Doctoral diss., University of Central Florida, 2010. http://digital.library.ucf.edu/cdm/ref/collection/ETD/id/2195.
Pełny tekst źródłaD.N.P.
School of Nursing
Other
Nursing Practice DNP
Zuzarte, Ian. "A principal component regression analysis for detection of the onset of nocturnal hypoglycemia in Type I diabetic patients". Akron, OH : University of Akron, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=akron1226955083.
Pełny tekst źródła"December, 2008." Title from electronic thesis title page (viewed 12/12/2009) Advisor, Dale H. Mugler; Committee members, Daniel B. Sheffer, Bruce C. Taylor; Department Chair, Daniel B. Sheffer; Dean of the College, George K. Haritos; Dean of the Graduate School, George R. Newkome. Includes bibliographical references.
McMahon, Sarah Kate. "Glucose requirements to maintain euglycaemia during and following moderate intensity afternoon exercise in adolescents with type 1 diabetes mellitus : an insight to the risk of exercise-associated hypoglycaemia". University of Western Australia. School of Paediatrics and Child Health, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0084.
Pełny tekst źródłaMedford, Cynthia D. "In vitro simulation experiments for the implementation of a nocturnal hypoglycemic alarm based on near-infrared spectroscopy". Ohio : Ohio University, 2004. http://www.ohiolink.edu/etd/view.cgi?ohiou1108144876.
Pełny tekst źródłaZuzarte, Ian Jeromino. "A Principal Component Regression Analysis for Detection of the Onset of Nocturnal Hypoglycemia in Type 1 Diabetic Patients". University of Akron / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=akron1226955083.
Pełny tekst źródłaBouchghoul, Hanane. "Déterminants de l’hypoglycémie néonatale et maternelle chez les femmes ayant un diabète gestationnel traité par glyburide Hypoglycemia and glycemic control with glyburide in women with gestational diabetes and genetic variants of cytochrome P450 2C9 and/or OATP1B3 Transplacental transfer of glyburide in women with gestational diabetes and neonatal hypoglycemia risk Assessment of risk of hypoglycemia by anthropometric measurements in neonates of mothers with treated gestational diabetes". Thesis, université Paris-Saclay, 2021. http://www.theses.fr/2021UPASR008.
Pełny tekst źródłaGestational diabetes (GD), whose prevalence in France was 10.8% in 2016, is associated with maternal and neonatal morbidity. Currently, the reference treatment is insulin therapy. Glyburide is effective, particularly in achieving glycemic control, compared with insulin. However, according to some studies, it is associated with an increased risk of maternal and neonatal hypoglycemia compared to insulin therapy.The main objective of this thesis was to better understand the determinants of maternal hypoglycemia and neonatal hypoglycemia based on ancillary and secondary analyses from the national randomized INDAO trial, published in 2018. The specific objectives were to investigate 1-the transplacental transfer of glyburide at delivery, 2-the association between neonatal anthropometric measures (weight-for-length ratio [WLR] and birth weight) and neonatal hypoglycemia in women receiving drug therapy for GD, 3-the association between maternal hypoglycemia and CYP2C9*2 reduced-function variants and CYP2C9*3 and OATP1B3*4 loss-of-function variants, and then in a second step to investigate the association between daily glyburide dose and carriers of loss-of-function and reduced-function variants.First, we showed that there was a placental transfer of glyburide with a fetal/maternal glyburide concentration ratio of 0.62 (95% CI 0.50-0.74). The risk of neonatal hypoglycemia increased significantly with increasing umbilical cord blood glyburide concentration, regardless of neonatal macrosomia. Second, we showed that the increased risk of neonatal hypoglycemia was independently associated with extreme values of WLR, for a low WLR Z-score (less than -1.28) and a high WLR Z-score (greater than 1.28), regardless of maternal treatment. Finally, we found an increased rate of maternal hypoglycemia at the beginning of glyburide treatment in the variant group including carriers of the CYP2C9*3 and/or OATP1B*4 allele in a homozygous state, associated with a smaller glyburide dose increment and a lower glyburide dose reached at the end of treatment.This thesis work provides new insights into the mechanism of action of glyburide in pregnant women, allowing for better use in the treatment of GD. However, the potential long-term consequences for the child of prolonged in utero exposure to glyburide remain
Kariuki, Anastacia Wanjiku. "The prevalence and nutritional causes of hypoglycaemia in patients with end-stage renal failure (ESRF) on maintenance haemodialysis (MHD) at Kenyatta National Hospital Nairobi, Kenya". Thesis, Link to the online version, 2008. http://hdl.handle.net/10019/1444.
Pełny tekst źródłaEriksson, Björn. "Risker med att patienter som behandlats prehospitalt för hypoglykemi kvarstannar i hemmet". Thesis, Örebro universitet, Institutionen för hälsovetenskap och medicin, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-23851.
Pełny tekst źródłaThat as an ambulance nurse treating patients with hypoglycemia in the home is a common practice, in relation to the increased burden on emergency departments, it is important to identify which patients need to be transported to the hospital. Most patients want to stay at home after treatment, to be aware of the potential risks that exist if the patient stays at home can make it easier to determine which patient should go to the hospital. The purpose of this study is to highlight the risks of patients being treated for hypoglycemia remains in the home. The study was conducted in the form of a literature review. Searches were made in the PubMed and Cinahl. These searches resulted in four articles that were included in the results. During the analysis of the articles revealed two problem areas, the risk of recurrent hypoglycemia and inadequate follow-up. In order to identify those patients who are at increased risk for recurrent hypoglycemia requires an adequate assessment of the nurse and that there are decision supportto help. Lack of follow-up of patients is the second problem area, which require improved cooperation between ambulance, hospital and primary care to improve monitoring, analysis showed that although the risk of recurrent hypoglycemia within 48 hours is low, so many of the patients repeated hypoglycemic episodes from a longer perspective, which emphasizes the importance of follow-up. There, ambulance nurse to be the initiating follow-up, it is important that the decision taken in consultation with the patient.
Metcalf, Kristen Marie. "Effects of moderate to vigorous-intensity physical activity on nocturnal and next day hypoglycemia in adolescents with Type 1 Diabetes". Thesis, University of Iowa, 2013. https://ir.uiowa.edu/etd/2580.
Pełny tekst źródłaMaltez, José Carlos. "Quantitative EEG analysis : temporal variability and clinical applications /". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-522-4/.
Pełny tekst źródłaYngen, Marianne. "Platelet function in diabetes mellitus : relationships to hyperglycaemia, antidiabetic treatment and microangiopathy /". Stockholm, 2005. http://diss.kib.ki.se/2005/91-7140-062-1/.
Pełny tekst źródłaLiu, Xu-Jing. "Effects of maternal dietary carbohydrate on phosphoenolpyruvate carboxykinase development in the fetus and neonate". Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=23282.
Pełny tekst źródłaDahlberg, Råger, i Ewa Spets. "Erfarenheter och upplevelser av hypoglykemi hos vuxna med diabetes mellitus : En kvalitativ intervjustudie". Thesis, Högskolan Dalarna, Omvårdnad, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:du-20858.
Pełny tekst źródłaBackground: Approximately one third of people with diabetes suffer episodes of hypoglycaemia with a loss of consciousness as a result. The incidence of hypoglycaemia is unpleasant and patients attempt to avoid this event, which often results in higher plasmaglucose values. Dedicated nursing care involves helping people to cope with unpleasant experiences of hypoglycaemia in daily life. Aim: To describe adults' experiences of hypoglycaemia in diabetes mellitus, and the consequences hypoglycaemia leads to daily life. Method: This study was conducted with a qualitative content analysis with an inductive approach. The study was conducted as a secondary analysis of semi-structured interwievs. The number of study participants were a total of 29 of which 15 with Type 1 diabetes and 14 with Type 2 diabetes. Results: The theme that emerged was: Hypoglycaemia is an ever present risk and is shaped differently with the following categories. Symptoms of hypoglycaemia could come as a bolt from the blue. Knowledge comes from life experiences. Training and exercise today - often have consequences tomorrow for patients. Self management could be perceived as a feeling of not being free. Family support – could mean security in illness. Conclusion: The incidence of hypoglycaemia is a common event and is perceived as unpleasant and unsafe event and causing fear in people suffering from diabetes. Undertreatment was seen as a consequence. Better support, help and information from the specialist nurses were needed. Knowledge and information, even to family members, was considered important to reduce the fear and discomfort of hypoglycaemia.
Blank, Maja, i Lina Johansson. "Fysisk aktivitet hos personer med diabetes typ 1 : Upplevelser och erfarenheter av information och stöd - en kvalitativ studie". Thesis, Uppsala universitet, Åsenlöf: Fysioterapi, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-411490.
Pełny tekst źródłaBackground: For people diagnosed with type 1 diabetes physical activity is important. It can improve glucose control over time. A need for further research about the support diabetics receive from healthcare professionals regarding physical activity has been expressed. There is also a need for investigating if diabetics experience fear of being physically active due to the risk of hypoglycemia. Purpose: The purpose of this qualitative study is to explore, through interviews, what support individuals with newly diagnosed type 1 diabetes receive from healthcare professionals regarding physical activity, and how they experience this support. The study will also illustrate what experiences people with type 1 diabetes have regarding fear of being physically active as well as what they believe can reduce that potential fear. Method: The study used a qualitative descriptive design, and data collection was conducted through five semi-structured interviews. Qualitative content analysis was used to process the data. Results: The interviewees’ experiences of the advice from healthcare professionals regarding physical activity was inconsistent. For those who have lived with diabetes for a shorter period of time, the advice was considered good but quite general. Those who have lived with their diabetes for a longer period of time thought that the advice was more individualized. More individualised advice was requested. None of the interviewees expressed specific fear of being physically active. Conclusion: The advice diabetics receives from healthcare professionals is considered good but insufficient. In the future more support will be needed regarding physical activity in the form of exercise-specific advice and encouragement.
Campbell, Teresa B. S. "ACACB encoding mitochondrial enzyme for carboxylation of acetyl-CoA is a novel disease-causing gene for congenital hyperinsulinemia". University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1592171025208869.
Pełny tekst źródłaVerdenhalven, Moritz [Verfasser], i Adriana del [Akademischer Betreuer] Rey. "Metabolic changes in the brain as consequence of IL-1-induced hypoglycemia: involvement of MyD88 / Moritz Verdenhalven. Betreuer: Adriana del Rey". Marburg : Philipps-Universität Marburg, 2015. http://d-nb.info/1076865771/34.
Pełny tekst źródłaSarem, Zeinab [Verfasser], i Florian J. [Akademischer Betreuer] Schweigert. "Regulation of IGF-1 bioactivity by dietary hormones, impact of glucagon and insulin-induced hypoglycemia / Zeinab Sarem ; Betreuer: Florian J. Schweigert". Potsdam : Universität Potsdam, 2015. http://d-nb.info/1218399732/34.
Pełny tekst źródłaSaugur, Anusooya. "Management of type 2 diabetes mellitus : a pharmacoepidemiological review". Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/1635.
Pełny tekst źródłaBulsara, Mahesh K. "Epidemiology of severe hypoglycaemia in children and adolescents with type 1 diabetes". Telethon Institute for Child Health Research, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0226.
Pełny tekst źródłaLouey, Samantha 1977. "The effects of intrauterine growth restriction on postnatal growth, arterial pressure and the vasculature". Monash University, Dept. of Physiology, 2003. http://arrow.monash.edu.au/hdl/1959.1/7939.
Pełny tekst źródłaBanin, Marcia Regina. "Caracteristicas clinicas, antropometricas e laboratoriais de pacientes com glicogenose". [s.n.], 2007. http://repositorio.unicamp.br/jspui/handle/REPOSIP/313374.
Pełny tekst źródłaDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Racional - As doenças de depósito de glicogênio compreendem um grupo de doenças geneticamente determinadas e classificadas em 11 tipos, de acordo com as deficiências enzimáticas identificadas. Há pouca informação sobre a evolução dessas doenças. Objetivos - Descrever as características clínicas e laboratoriais, na admissão e evolução, de pacientes com doença de depósito de glicogênio. Pacientes e métodos ¿ Participaram do estudo 22 pacientes com diagnóstico de glicogenose hepática, sendo 11 (50%) do sexo feminino. O estudo foi descritivo e longitudinal. A ficha de coleta de dados constituiu-se de informações iniciais de: quadro clínico, peso, estatura, índice de massa corporal (IMC) e resultados dos exames laboratoriais (hemograma, enzimas hepáticas, colesterol total e frações, triglicérides, glicemia, ácido úrico, uréia e creatinina). Selecionou-se os momentos 1 (admissão), 3 (12 meses de evolução) e 7 (36 meses de evolução) para coleta dos seguintes dados: peso, estatura, IMC, ácido úrico, glicemia, colesterol e triglicérides. Também, foram comparados os resultados de antropometria e exames bioquímicos dos pacientes em dois momentos: admissão e última consulta. Para as variáveis peso e estatura, calculou-se o Z escore sendo considerado déficit quando o valor se situava abaixo do segundo desvio padrão. A velocidade de crescimento foi calculada a partir da 2ª e 1ª consulta (V1) e a partir da última e penúltima consulta (V2). A taxa de aderência foi determinada pela porcentagem de absenteísmo das consultas da seguinte forma: boa: se absenteísmo menor que 20%; regular: se absenteísmo entre 20% e 40% e ruim: se absenteísmo maior que 40%. Utilizou-se como teste estatístico a análise de variância e os testes de Kruskal-Wallis, Mann-Whintney e Wilcoxon, sendo o nível de significância adotado de 5%. Resultados - A média da idade de início dos sintomas foi de 10,7 meses e do diagnóstico de 28,18 meses. O tempo médio de seguimento foi de 105 meses. As manifestações clínicas iniciais mais freqüentes foram: hepatomegalia em 21 (95%), abdômen protuberante em 19 (86%), face de boneca em 14 (64%), diarréia em 10 (45%) e história de hipoglicemia em 8(36%). Nos exames laboratoriais, observou-se, na maioria dos casos, aumento das enzimas hepáticas, hipercolesterolemia, hipertrigliceridemia e hipoglicemia. Na admissão, o déficit de peso/idade foi de 26% (5/19) e de estatura/idade foi de 35% (7/20). Não houve diferença estatística na comparação do Z escore de peso/idade, estatura/idade, índice de massa corporal e exames laboratoriais na admissão, com 12 e 36 meses. Entre a admissão e a última consulta, observou-se diferença significativa no índice de massa corporal, enzimas hepáticas, glicemia e triglicérides, o que não aconteceu com Z escore de peso/idade, estatura/idade e os exames de ácido úrico e colesterol. A taxa de aderência foi considerada boa em 64% dos pacientes. Na comparação da velocidade de crescimento, observou-se tendência de aumento comparando V1 com V2. Conclusões ¿ Houve demora no encaminhamento ao centro de referência para o diagnóstico das glicogenoses. As manifestações clínicas mais freqüentes foram abdômen protuberante e hepatomegalia e as alterações laboratoriais mais significativas foram a elevação dos triglicérides, colesterol e diminuição da glicemia. Na evolução, não houve diferença nos parâmetros antropométricos, mas uma tendência de melhora de velocidade de crescimento. O tratamento melhorou o desarranjo metabólico
Abstract: Background ¿ Glycogen storage diseases comprise a group of genetic diseases determined and classified into 11 types, according to the identified enzymatic deficiency. There is little information regarding the disease evolution. Aim ¿ Describe clinical and laboratorial characteristics in the admission and evolution of patients with glycogen storage disease. Patients and methods ¿ Twenty-two patients with hepatic glycogen diagnosis participated in the study, 11 (50%) of which were female. The study was descriptive and longitudinal. The collected data file consisted of admission information: clinical features, weight, height, body mass index (BMI) and laboratorial exam results: hemogram, hepatic enzymes, total cholesterol and fractions, triglycerides, glycemia, uric acid, urea and creatin. Afterwards, the following phases were selected: 1 (admission), 3 (12 months of evolution) and 7 (36 months of evolution) for the weight, height, BMI and laboratorial tests: uric acid, glycemia, total cholesterol and triglycerides. The antropometric data, hepatic enzymes and mentioned tests were compared during 2 moments: admission and last appointment of each patient. The score Z was utilized to evaluate the weight and height of patients, considered if the standard deviation was under 2. The growth velocity was calculated among the second and first consult and the last and the penultimate consult. The adherence percentage was determined by the appointment absence percentage: Good: absenteeism minor 20%; regular: absenteeism major 20% and minor 40%; bad: absenteeism major 40%. The statistical tests applied were ANOVA, Kruskal-Wallis, Mann-Whintney, and Wilcoxon. The significance level was 5%. Results - The mean time during the first symptoms was 10,73 months and the mean time up to diagnosis was 28,18 months. The mean time of follow-up was 105 months. The most frequent initial clinical manifestations were: hepatomegaly in 21 (95%), protuberant abdomen in 19 (86%), doll face in 14 (64%), diarrhea in 10 (45%) and history hypoglycemia in 8 (36%). In the admission the deficit of the weight to age was 26% (5/19) and height to age was 35% (7/20), In the initial biochemical tests showed elevation of hepatic enzymes, hypercholesterolemia, hypertriglyceridemia, hypoglycemia. There was no statistical difference among the score Z weight to age, score Z height to age, body mass index and laboratorial tests of admission within 12 and 36 months. Significant differences were observed in BMI, hepatic enzymes, glycemia and triglycerides between the first and the last appointments, opposing to the score Z weight to age, score Z height to age, uric acid and cholesterol exam results. In the comparison of the growth velocity there was elevation tendency between the V1 and V2. There was difference significative of the growth velocity among the first and second versus the penultimate and the last consult. The adherence percentage was considered good in 64%. Conclusions - The patients delayed in seeking the reference center for glycogenosis early diagnosis. The most frequent clinical manifestations were protuberant abdomen, hepatomegaly, elevation of triglycerides and cholesterol, and glycemia reduction. In the evolution, there wasn¿t difference statistic in the antropometric parameters, but there was improvement tendency on the growth velocity. The treatment has improved the metabolic derangement
Mestrado
Saude da Criança e do Adolescente
Mestre em Saude da Criança e do Adolescente
ALEIXO, Grazielle Anahy de Sousa. "Comparação da glicemia em cães utilizando o glicosímetro portátil e o método de referência laboratorial". Universidade Federal Rural de Pernambuco, 2006. http://www.tede2.ufrpe.br:8080/tede2/handle/tede2/5673.
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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
The increase or decrease in the glucose concentration in the blood is a common endocrine alteration in human beings and animals that can cause serious consequences to their health condition. Dosing the glucose of patient with hypo or hyperglycemia allows the same ones to receive appropriate treatment, propitiating a better life quality. The present work had as object to determine the glycemic values of dogs using a portable glucometer (Accu-Chek® Advantage / Roche) projected for human patients, and to compare the results obtained with that equipment to those acquired with the enzymatic-colorimeter (GOD-POD) according to Trinder laboratorial method, since it is considered a standard technique. Once proving that exists a good correlation among the results obtained with the two methods, it becomes possible for the Veterinary Doctors to use the glucometer in their routine with the intention of diagnosing alteration in their patients' glycemia and nevertheless, obtain important information that will help to govern the therapeutic conducts in animals with diseases such as Diabetes mellitus. Another purpose of this work was to describe which factors can alter the precision of the results obtained with the portable glucometer. For the development of the research 53 animals of the canine species, of varied age, sex, weight and breed, assisted at the Veterinary Hospital of the Department of Veterinary Medicine (DMV) of the Rural Federal University of Pernambuco (UFRPE) were used). In 17 patients it was observed factors of risks that could alter the precision of the results in the glucometer, such as low hematocrit, inadequate soak of the test strip, a part of the sample was over the reagent strip or still, the accomplishment of the test passed the 15 seconds recommended by the manufacturer of the equipment, and as consequence, only 36 animals were considered eligible for the study of the evaluation of the portable glucometer in relation to the laboratorial method. It was concluded that the glucose dosage in dogs using the portable glucometer Accu-Chek® Advantage can be considered clinically useful, because the differences obtained among the methods are inside of the margin established by the regulators entities of the area.
O aumento ou a diminuição da taxa de glicose no sangue é uma alteração endócrina comum em seres humanos e animais, e que pode ocasionar graves conseqüências ao estado de saúde dos mesmos. Dosar a glicose sangüínea de pacientes portadores de hipo ou hiperglicemia permite que eles recebam adequado tratamento, propiciando uma melhor qualidade de vida. O presente trabalho teve como objetivo determinar os valores glicêmicos em cães utilizando um glicosímetro portátil (Accu-Chek® Advantage / Roche Diagnóstica Brasil Ltda.) projetado para pacientes humanos, e comparar os resultados obtidos com esse equipamento àqueles conseguidos com o método laboratorial enzimático-colorimétrico (GOD-POD) segundo Trinder, que é considerado uma técnica padrão. Uma vez comprovada que existe uma boa correlação entre os dois métodos, torna-se possível para os Médicos Veterinários utilizarem o glicosímetro na sua rotina com o intuito de diagnosticar alterações na glicemia de seus pacientes e, ainda assim, obterem informações importantes que vão ajudar a reger as condutas terapêuticas em animUma outra finalidade deste trabalho foi descrever quais fatores de risco podem alterar a precisão dos resultados obtidos com o glicosímetro portátil. Para o desenvolvimento da pesquisa foram utilizados 53 animais da espécie canina, de idades, sexos, pesos e raças variadas, atendidos no Hospital Veterinário do Departamento de Medicina Veterinária (DMV) da Universidade Federal Rural de Pernambuco (UFRPE). Em 17 pacientes foram observados fatores que poderiam alterar a precisão dos resultados no glicosímetro, como baixo hematócrito, embebição inadequada da tira teste, uma parte da amostra ficou por cima da tira reagente ou ainda, a realização do teste ultrapassou os 15 segundos recomendados pelo fabricante do equipamento e, como conseqüência, apenas 36 animais foram considerados elegíveis para o estudo da avaliação do glicosímetro portátil em relação ao método laboratorial. Concluiu-se que a dosagem de glicose em cães utilizando o glicosímetro portátil Accu-Chek® Advantage pode ser considerada clinicamente útil, pois as diferenças obtidas entre os métodos estão dentro da margem estabelecida pelos órgãos reguladores da área.
Santos, Joana Cuba Macedo dos. "Insulinoma em furões". Master's thesis, Universidade de Lisboa. Faculdade de Medicina Veterinária, 2016. http://hdl.handle.net/10400.5/11732.
Pełny tekst źródłajoana.cmds@gmail.com
Os primeiros casos de insulinoma no furão (Mustela putorius furo) aparecem documentados na literatura nos anos 80, sendo hoje em dia uma das neoplasias mais diagnosticadas nesta espécie. A neoplasia das células Beta dos ilhéus pancreáticos, mais frequentemente designada por insulinoma, produz os seus efeitos através da hipersecreção de insulina e é a hipoglicémia resultante que acaba por se traduzir numa variedade de sinais clínicos. Este estudo descreve a apresentação clínica, o diagnóstico, as opções terapêuticas e o prognóstico do insulinoma, dada a relevância clínica desta patologia no furão doméstico. Foram seguidos 10 casos durante o período de estágio curricular, que pretendem ser um reflexo daquilo que pode ser encontrado na prática clínica. Os sinais clínicos predominantes na amostra foram a perda de peso, apatia, vómito e ptialismo (n=7), sendo a apresentação crónica, com desenvolvimento lento de sinais ao longo de semanas ou meses, a mais observada (n=6). O diagnóstico foi obtido presuntivamente na maior parte dos casos, pois a confirmação histopatológica só foi possível em 3 animais. A determinação da concentração da glucose sanguínea com o glucómetro e a ecografia abdominal foram os exames complementares que se revelaram mais valiosos para o diagnóstico. A maioria dos furões (n=8) recebeu um tratamento combinado, médico e cirúrgico. O tratamento médico consistiu sobretudo na administração de glucocorticoides (prednisona) com adição de diazóxido, e o tratamento cirúrgico baseou-se na execução de pancreatectomia parcial. Quatro animais tornaram-se euglicémicos imediatamente após a pancreatectomia, outros quatro passaram para um estado hiperglicémico com necessidade de insulinoterapia e um permaneceu hipoglicémico. Nos animais que demonstraram recidiva de sinais clínicos durante o período de seguimento (n=7), o tempo até recidiva foi, em média, de 181 dias. A eutanásia foi por duas vezes o último recurso, por agravamento do quadro de insulinoma. Por fim, e uma vez que o comportamento biológico do insulinoma no furão difere do de outras espécies, foram também discutidos alguns aspetos comparativamente ao insulinoma no cão.
ABSTRACT - Insulinoma in ferrets - The first reports of insulinoma in ferrets (Mustela putorius furo) began appearing in the literature in the 1980s, and this is now one of the most common neoplastic disease diagnosed in this species. Pancreatic islet beta cell tumors, more commonly known as insulinomas, oversecrete insulin which results in hypoglycemia, causing the wide variety of clinical signs present in this condition. This study describes the clinical presentation, diagnosis, treatment options and prognosis of insulinoma, given the clinical relevance of this condition in the ferret. Ten cases were observed during the curricular internship, and their purpose is to mirror what can be found in a clinical environment on a daily basis. The most common clinical signs were weight loss, apathy, vomiting and ptyalism (n=7), with a chronic onset over the course of weeks or months (n=6). A tentative diagnosis was made in most cases, because histological confirmation was possible in only 3 cases. Measurement of blood glucose concentration with a portable blood glucose meter and abdominal ultrasonography appeared to be the most valuable diagnostic procedures. Most ferrets (n=8) were treated medically and surgically. Medical management consisted of glucocorticoids administration (prednisone) combined with diazoxide, and partial pancreatectomy was performed as surgical therapy. Four pacients became euglycemic in the immediate postoperative period, four others developed postoperative hyperglycemia and required insulin injections, and one remained hypoglycemic. The mean disease-free interval was 181 days, in those cases where recurrence of clinical signs was observed during the follow-up period (n=7). Two ferrets were euthanized due to worsening of the disease. Finally, and once the biological behavior of insulinoma in ferrets is different than that in other species, some comparative aspects of the canine insulinoma were also briefly discussed.