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Rozprawy doktorskie na temat „HYPERTENSIVE DRUGS”

Autor: Grafiati

Data publikacji: 11 września 2023

Data aktualizacji: 25 lipca 2025

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1

Nievelstein, Hubert Nicolas Maria Willem. "Hemodynamic effects of antihypertensive drugs in conscious spontaneously hypertensive rats." Maastricht : Maastricht : Rijksuniversiteit Limburg ; University Library, Maastricht University [Host], 1987. http://arno.unimaas.nl/show.cgi?fid=5367.

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Beaubien, Eliot R. "Non-steroidal anti-inflammatory drugs and the risk of end stage renal disease in hypertensive individuals." Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=81593.

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Objective. To examine the association between non-steroidal anti-inflammatory drug (NSAID) use and end stage renal disease (ESRD) among hypertensive subjects.<br>Study design. We conducted a nested case-control study within a cohort of 77,887 hypertensive adult subjects within the province of Saskatchewan, Canada.<br>Outcome. The primary outcome was ESRD, defined by chronic dialysis or renal transplantation.<br>Exposure. NSAID exposure was determined using prescription records, for various time windows up to 10 years preceding the onset of end stage renal disease.<br>Statistical analysi

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3

Komulainen, S. (Silja). "Effect of antihypertensive drugs on blood pressure during exposure to cold:experimental study in normotensive and hypertensive subjects." Doctoral thesis, University of Oulu, 2007. http://urn.fi/urn:isbn:9789514286131.

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Abstract The aim of the present study was to describe the effects of different types of cold exposures on blood pressure (BP) and heart rate (HR) and to test how these cold-induced effects are modulated by antihypertensive drugs representing different kind of mechanisms of action. The tested drugs represented the following antihypertensive drug subgroups: metoprolol from beta-blocking agents, carvedilol from alfa- and beta-blocking agents, lisinopril from angiotensin converting enzyme inhibitors, eprosartan from angiotensin II antagonists, amlodipine from calcium channel blockers and hydrochlo

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4

Filho, Gilberto Senechal de Goffredo. "Incapacidade temporária para atividades habituais: relação com a pressão arterial e o uso de terapia farmacológica antihipertensiva no Estudo Pró-Saúde." Universidade do Estado do Rio de Janeiro, 2008. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=5021.

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A hipertensão arterial (HA) desempenha papel determinante na ocorrência de eventos clínicos graves, havendo entretanto controvérsia quanto ao seu impacto no cotidiano do portador. A incapacidade temporária para a realização de atividades habituais, definida como uma restrição temporária na capacidade funcional habitual do indivíduo, é um indicador de saúde recomendado pela Organização Mundial da Saúde para uso em estudos populacionais. A partir do objetivo geral de investigar a associação entre hipertensão arterial e incapacidade temporária para atividades habituais, delineamos os seguintes ob

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5

Forino, Andrew Stephen. "Determining Effects of the PAF-R and Anti-Hypertensive Drugs Mediated Microvesicle Particle Release in Modulating Anti-Tumor Response of Lung Cancer." Wright State University / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=wright1590691151424173.

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6

Merlo, Juan. "Pharmacoepidemiologic studies on cardiovascular drugs with special reference to the effectiveness and safety of blood pressure lowering drugs /." Lund : Dept. of Community Medicine, Lund University, and the NEPI Foundation, 1998. http://books.google.com/books?id=c_BsAAAAMAAJ.

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7

Moore, Suzanne P. "Adherence to randomised drug regimens of patients enrolled in the Second Australian National Blood Pressure Study : a description of the patterns of adherence and of factors influencing non-adherence /." [St. Lucia, Qld.], 2001. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe16251.pdf.

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8

Yates, John. "Haemodynamic effects of vasoactive drugs in experimental portal hypertension." Thesis, Liverpool John Moores University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.337787.

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9

Yu, Zhen. "Altered drug responses in diabetic and hypertensive-diabetic cardiomyopathy." Thesis, University of British Columbia, 1990. http://hdl.handle.net/2429/29406.

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Diabetes mellitus has been associated with both clinical and experimental cardiac dysfunction. Diabetic cardiomyopathy which is characterized by depressed cardiac contractility is accompanied by a variety of biochemical changes in Ca⁺⁺ metabolism. This cardiomyopathy may occur in the presence of normal coronary arteries and normal blood pressure. However, some studies have shown that hypertension is more prevalent among diabetics and can aggravate the cardiovascular abnormalities associated with diabetes. To understand the mechanisms of diabetic cardiomyopathy and consequences of combined hype

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10

Greer, I. A. "The effect of anti-hypertensive agents on platelets, prostacylin and thromboxane and observations on prostacyclin and thromboxane in normal and hypertensive pregnancy." Thesis, University of Glasgow, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380334.

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11

Rasmussen, Kelly. "The Impact of JNC-7 and New Clinical Studies on Antihypertensive Drug Prescribing." The University of Arizona, 2005. http://hdl.handle.net/10150/624769.

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Class of 2005 Abstract<br>Objectives: The objectives of this study were to assess the number of antihypertensive prescriptions by therapeutic class including beta-blockers, calcium channel blockers (CCBs), diuretics, angiotensin-converting enzyme inhibitors (ACEIs), and angiotensin receptor blockers (ARBs), dispensed in the fiscal years 2002 through 2004. Methods: The project was a retrospective analysis of pharmacy data for medications used to treat hypertension from October 2002 through December 2004 (FY02 through the first quarter of FY05). Drug classes used to treat hypertension were obta

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12

Yoon, Jean. "Adherence to prescription drugs and adverse health events for patients with hypertension." Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1679722851&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.

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13

Sanders, Gillian. "Therapeutic interventions in the management of hypertension : clinical studies in individuals and the community." Thesis, University of Newcastle Upon Tyne, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329166.

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14

Capewell, Simon. "Studies of the calcium antagonist felodipine in the treatment of hypertension and heart failure." Thesis, University of Newcastle Upon Tyne, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.330281.

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15

Nordmann, Alain Joel. "Cost-effectiveness of routine echocardiography in hypertensive patients starting antihypertensive drug therapy." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2001. http://www.collectionscanada.ca/obj/s4/f2/dsk3/ftp04/MQ58821.pdf.

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16

Persson, Mats. "Bring hypertension guidelines into play : guideline-based decision support system for drug treatment of hypertension and epidemiological aspects of hypertension guidelines." Doctoral thesis, Umeå universitet, Allmänmedicin, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-94105.

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17

Lu, Changwu [Verfasser]. "Antifibrotic drugs: new candidates for the treatment of pulmonary arterial hypertension? / Changwu Lu." Gießen : Universitätsbibliothek, 2018. http://d-nb.info/1163533688/34.

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18

Chellingsworth, Miriam Claire. "Could a calcium antagonist be the ideal drug treatment of elderly hypertensives?" Thesis, University of Southampton, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316397.

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19

Cowan, Simone. "Anti-hypertensive drug use and the risk of serious hypoglycemia in patients with diabetes." Thesis, McGill University, 1999. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=30840.

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Recently, there have been conflicting reports on whether anti-hypertensive medications cause serious hypoglycemia in patients with diabetes. We assessed this association using a population-based approach.<br>Utilizing the Saskatchewan Health databases, we conducted a case-control study nested within a cohort of 3639 patients with diabetes, newly prescribed angiotensin converting enzyme inhibitors (ACE-I) or dispensed other anti-hypertensive drugs during 1982 to 1987. There were 162 cases of hypoglycemia identified. All potential controls, matched to the case on entry date and at different elig

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20

Griffith, D. N. W. "The cerebral circulation in diabetes mellitus and hypertension and its responses to beta adrenergic receptor-blocking drugs." Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599714.

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21

Wathen, Christopher George. "Studies of the cardiovascular effects of inotropic agents and vasodilators on the pulmonary and systemic circulation in man." Thesis, University of Edinburgh, 1988. http://hdl.handle.net/1842/27032.

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22

Lees, K. R. "Studies of the clinical pharmacology of perindopril : A new inhibitor of angiotensin converting enzyme." Thesis, University of Glasgow, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383183.

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23

Mchowat, Jane. "Cardiovascular control by central beta-adrenoceptors in the rat." Thesis, University of Bath, 1987. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.380621.

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24

Kung, Kin-hang. "An audit on anti-hypertensive drug management amongst general out-patient clinics in New Territories West region." Click to view the E-thesis via HKUTO, 2004. http://sunzi.lib.hku.hk/hkuto/record/B31971878.

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25

Kung, Kin-hang, and 龔健恆. "An audit on anti-hypertensive drug management amongst general out-patient clinics in New Territories West region." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31971878.

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26

Chetty, Prakash. "Development and assessment of propranolol sustained release dosage forms separately and in combination with hydrochlorothiazide." Thesis, Rhodes University, 2006. http://eprints.ru.ac.za/1342/.

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27

Chu, Wai-on. "The prevalence of cognitive impairment and dementia among hypertensive elderly as a whole and among different classes of anti-hypertensive drug users in a regional geriatric clinic in Hong Kong /." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38348202.

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28

Kondowe, Greeves Burton Chianira. "An investigation of some of the mechanisms of action of angiotensin converting enzyme inhibitors." Thesis, Queen's University Belfast, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.254326.

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29

Waller, Patrick Charles. "Pharmacokinetics and antihypertensive effect of the serotonin antagonist ketanserin." Thesis, University of Sheffield, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335054.

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30

Hatton, R. "The role of angiotensin in the control of blood pressure : a functional interaction with the autonomic nervous system." Thesis, Open University, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.378202.

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An interaction of the renin-angiotensin system and the autonomic nervous system was demonstrated in vivo during activation of the former by sodium depletion in the dog and the latter during application of lower body negative pressure (LBNP) in the cat. In the dog, inhibitors of angiotensin converting enzyme (ACE), teprotide and captopril, together with an angiotensin II (AII) antagonist, saralasin, and a peptide inhibitor of renin, H77, given intravenously lowered blood pressure (BP) by reducing peripheral resistance in relation to the prevailing level of plasma renin activity (PRA). They did

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31

Girvan, B. G. "The influence of drug dosing interval on patient compliance with antihypertensive agents and the effect of non-compliance on blood pressure control." Thesis, Queen's University Belfast, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.268921.

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32

HAMAJIMA, NOBUYUKI, YOSHITOKU YOSHIDA, AMONOV MALIK, SALIM DAVLATOV, and ERKIN TOIROV. "HYPERTENSION-RELATED KNOWLEDGE, PRACTICE AND DRUG ADHERENCE AMONG INPATIENTS OF A HOSPITAL IN SAMARKAND, UZBEKISTAN." Nagoya University School of Medicine, 2014. http://hdl.handle.net/2237/20544.

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33

Kim, Eunju. "Sequential drug decision problems in long-term medical conditions : a case study of primary hypertension." Thesis, University of Sheffield, 2015. http://etheses.whiterose.ac.uk/10004/.

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Background: Sequential drug decision problems (SDDP) occur when assigning drugs sequentially in long-term medical conditions. SDDPs are important for both clinical decision-making and resource allocation. They can be large and complex because of the considerable number of drug sequences and disease pathways and the interdependence between them over time. Where classic mathematical programming has a limited capacity for dealing with the complexities of a sequential decision problem, approximate optimisation methods have been widely used to solve the problem more efficiently using simulation. Ob

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34

Nikam, Vandana S. "Identification of circulating fibrocytes as a new and specific pharmacological target in a murine model of pulmonary hypertension." Giessen VVB Laufersweiler, 2008. http://d-nb.info/1000204677/04.

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35

Pietras, Kristian. "Inhibition of PDGF receptor signaling in tumor stroma : Effects on interstitial hypertension, drug uptake and therapeutic response." Doctoral thesis, Uppsala University, Ludwig Institute for Cancer Research, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2633.

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<p>The role of platelet-derived growth factor (PDGF) in malignancies involves both autocrine and paracrine stimulation of cells within the tumor. The interstitial fluid pressure (IFP) is one of the forces that govern the transvascular flow of fluids. In both experimental and clinical cancers, the IFP is elevated and is thought to act as a barrier for delivery of drugs. Increasing evidence points to PDGF as a positive regulator of the interstitial fluid pressure in loose connective tissue. In this thesis, the effect of PDGF receptor inhibition on the tumor IFP, transvascular transport and effic

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36

Zarnke, Kelly B. "Hypertension management using home blood pressure monitors and patient-initiated drug dosage adjustments, a randomized equivalence trial." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/tape17/PQDD_0033/MQ30705.pdf.

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37

Sobko, D. I. "Blood pressure changes as a result of taking nonsteroidal anti-inflammatory drugs among the patients who suffer from osteoarthritis with concomitant hypertension." Thesis, БДМУ, 2020. http://dspace.bsmu.edu.ua:8080/xmlui/handle/123456789/18060.

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38

Selvey, Christine Enid. "Comparative effects of calcium channel antagonism and beta-1 selective blockade on exercise performance in physically active hypertensive patients." Master's thesis, University of Cape Town, 1997. http://hdl.handle.net/11427/26736.

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The current recommendations by the American Heart Association for health promotion are that all persons should partake in regular physical activity in order to reduce the risk of cardiovascular disease. Regular physical exercise reduces blood pressure and is an important component of the management of hypertension. It is therefore important that patients with hypertension participate in habitual physical exercise. Many hypertensive patients who exercise will require anti-hypertensive medication. However, some antihypertensive agents cause fatigue during exercise. In order for patients to gain

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39

Lévi, Natacha. "Impact et réversibilité du syndrome métabolique et de ses composantes sur le vieillissement cognitif et le risque de démence." Thesis, Paris Est, 2012. http://www.theses.fr/2012PEST0080.

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L’hypertension artérielle (HTA) est considérée comme un facteur de risque modifiable de démence. Dans ce contexte, nous nous sommes intéressés à différents aspects du traitement de l’HTA indépendamment de la réduction de pression artérielle : d’une part aux effets des différentes classes d’antihypertenseurs sur le déclin cognitif et l’incidence de démence, en réalisant une méta-analyse en réseau ; et, d’autre part, sur la variabilité depression artérielle (PA), qui pourrait être impliquée dans la relation délétère entre l’HTA et la cognition, à partir d’une cohorte de sujets hypertendus traité

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40

Fitton, Catherine Alexandra. "Identifying adverse outcomes in neonates and children following in utero exposure to medication." Thesis, University of Aberdeen, 2019. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=240861.

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Introduction: Many medications have an unproven safety profile for use during pregnancy, leading to issues when chronic diseases, such as hypertension and depression, present during pregnancy. The focus of this research programme is to determine whether in utero exposure to antihypertensive and antidepressant medication is associated with increased risk of adverse events at birth, and up to 27 months of age in the child. Methods: Two systematic reviews were performed to identify current published literature and knowledge gaps. Following this, using Scottish healthcare data, a cohort of 268,711

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41

Sutton, Sandra Cecile. "The development of a method to evaluate the use and medical and socioeconomic implications of antihypertensive drug treatment in the Mamre community." Thesis, University of Cape Town, 1994. http://hdl.handle.net/11427/25756.

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42

Graden, Suzanne. "National Estimate of Cost of Illness for Hypertension and Non-Persistence with Drug Therapy Using the Medical Expenditure Panel Survey." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1046972930.

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43

Ericson, Karin, and Mimmi Moser. "Faktorer som påverkar patienters följsamhet till behandling vid hypertoni." Thesis, Högskolan i Halmstad, Sektionen för hälsa och samhälle (HOS), 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-16899.

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Hypertoni är en folksjukdom och en riskfaktor för hjärt-kärlsjukdom. Effektiva behandlingsmetoder finns men brist på följsamhet till behandlingsregimer vid hypertoni är ett stort problem, som utgör en risk för patienters hälsa. Bättre kunskap om vad som kan påverka patienternas följsamhet till hypertonibehandling är därmed av stor betydelse för sjuksköterskans hälsofrämjande arbete. Syftet med studien var att undersöka faktorer som påverkar patienters följsamhet till behandling vid hypertoni. Studien genomfördes som en litteraturstudie. Data bestod av 16 vetenskapliga artiklar som valdes ut, g

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44

Vieira, Suenimeire. "Estudo das adaptações morfológicas e funcionais cardíacas promovidas pela abordagem farmacológica em associação ao treinamento físico aeróbio em ratos hipertensos." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17152/tde-26042018-120135/.

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O tratamento da hipertensão arterial sistêmica (HAS) mais usual envolve uma abordagem farmacológica baseada, principalmente, na inibição do sistema renina-angiotensinaaldosterona (SRAA). Contudo, outras abordagens têm sido utilizadas com excelentes resultados, como a prescrição de exercícios físicos regulares, principalmente o aeróbio, muitas vezes como terapia coadjuvante ao tratamento farmacológico. No entanto, embora a literatura mostre que a associação dos tratamentos promova maiores reduções da pressão arterial (PA), pouco sabemos sobre os efeitos teciduais e funcionais cardíacos. Portant

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45

Siew, Keith. "Gitelman & Gordon : mirror image syndromes reveal the roles of WNKs in blood pressure homeostasis and novel anti-hypertensive targets." Thesis, University of Cambridge, 2019. https://www.repository.cam.ac.uk/handle/1810/289398.

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Study of Gordon (PHAII) and Gitelman (GS) syndromes revealed the importance of the WNK pathway and thiazide-sensitive Na-Cl Cotransporter (NCC) in the renal control of blood pressure. PHAII mutations lead to WNK accumulation resulting in the hyperphosphorylation of the downstream effector, SPAK, which overactivates NCC causing salt retention and hypertension. Mutations causing deletion of exon-9 in Cullin-3, which normally ubiquitylates WNKs for degradation, were recently discovered to cause the severest subtype of PHAII (PHA2E) with early onset salt-sensitive hypertension and hyperkalaemia. T

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46

Hascoët, Sébastien. "Thérapies avancée de l'hypertension artérielle pulmonaire associée aux cardiopathies congénitales Pumpless Lung Assist as a Bridge to Medical Therapy in a Teenager With Pulmonary Arterial Hypertension and Partial Anomalous Pulmonary Venous Return Transplantation for Pulmonary Arterial Hypertension with Congenital Heart Disease: Impact of Current Therapeutic Approach Including a High-Priority Allocation Programme on Outcomes Outcome of adults with Eisenmenger syndrome treated with drugs specific to pulmonary arterial hypertension: A French multicentre study Long-term outcomesofpulmonaryarterial hypertension underspecific drugtherapyin Eisenmenger syndrome." Thesis, université Paris-Saclay, 2020. http://www.theses.fr/2020UPASQ010.

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Résumé : Les cardiopathies congénitales sont les anomalies congénitales les plus fréquentes. Grâce aux progrès dans la prise en charge chirurgicale, environ 90% des enfants ayant une cardiopathie congénitale vivent désormais jusqu’à l’âge adulte. Néanmoins, l’évolution clinique de ces patients peut être marquée par des complications, dont l’hypertension artérielle pulmonaire. Celle-ci peut se développer secondairement à l’absence ou au retard de prise en charge dans l’enfance ou à des lésions résiduelles. L’hypertension artérielle pulmonaire est associée à un pronostic altéré, essentiellement

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Prestipino, Louise. "Developmental Programming of Cardiovascular Control: How Maternal Factors Influence the Health of the Adult Offspring." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/23005.

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There is accumulating evidence that hypertension is a symptom of underlying autonomic dysfunction, including aberrant stress responses. Before autonomic activity is examined in models of hypertension, the underlying connectivity that drives stress responses under physiological conditions must be further elucidated. In Chapter 3, we examined the afferent connectivity of the dorsomedial hypothalamus (DMH) by combining retrograde tracing and Fos immunohistochemistry following air jet stress. Stress-activated, DMH-projecting neurons were located predominantly in forebrain nuclei. Total numbers of

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48

Penha, Lilliam Rocha. "Mieloperoxidase em síndromes hipertensivas da gestação." Botucatu, 2017. http://hdl.handle.net/11449/149735.

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Orientador: Valéria Cristina Sandrim<br>Resumo: A enzima mieloperoxidase (MPO) é caracterizada por produzir substâncias altamente reativas e é reconhecida por desencadear estresse oxidativo e disfunção endotelial mediada, em parte, pela interferência com o vasodilatador óxido nítrico. Neste estudo, nós investigamos a relação entre o óxido nítrico e a MPO in vitro incubando o plasma de gestantes saudáveis, hipertensas e com pré-eclâmpsia com células endoteliais (HUVEC). Foram observados maiores níveis de MPO no sobrenadante de células incubadas com o plasma de pacientes com pré-eclâmpsia compar

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49

SINGH, BHAWNA. "EXPLORING MOLECULAR TARGETS FOR REPOSITIONING OF HYPERTENSIVE DRUGS." Thesis, 2020. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18299.

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Drug repositioning or drug repurposing or drug profiling is the discovery of new applications for approved or failed drug.. Drug repositioning is the development of new approved drug applications.The cost of bringing a medicine to the market is around one million which include clinical and preclinical trials.Repositioning of drugs help in cutting down costs as well as time involve in intial validation and authorization . The procedure involved in Drug repositioning is generally performed during the drug development phase to modify or extend an active molecule's distribution line. On a fun

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"Haemodynamic effects of different anti-hypertensive drugs." Chinese University of Hong Kong, 1995. http://library.cuhk.edu.hk/record=b5888527.

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Lau Siu Wai Maggie.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1995.<br>Includes bibliographical references (leaves 236-245).<br>List of Figures --- p.i<br>List of Tables --- p.viii<br>List of Abbreviations --- p.x<br>Abstract --- p.xii<br>Chapter Chapter 1 --- Introduction --- p.1<br>Chapter 1.1 --- Postulated Pathophysiology of Essential Hypertension --- p.1<br>Chapter 1.2 --- Measurement of Cardiac Output (CO) by Transthoracic Electrical Bioimpedance (TEB) and Other Methodologies --- p.6<br>Chapter 1.3 --- Measurement of Blood Pressure --- p.10<br>Chapter 1.4 --- Use of A

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