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Artykuły w czasopismach na temat "Hygromycine"
Hussain, Iqra. "INTRODUCTION OF RICE CHITINASE GENE IN POTATO BY AGROBACTERIUM-MEDIATED TRANSFORMATION". Pakistan Journal of Agricultural Sciences 56, nr 01 (1.01.2019): 7–13. http://dx.doi.org/10.21162/pakjas/19.8154.
Pełny tekst źródłaChen, Grace Q. "Effective Reduction of Chimeric Tissue in Transgenics for the Stable Genetic Transformation of Lesquerella fendleri". HortScience 46, nr 1 (styczeń 2011): 86–90. http://dx.doi.org/10.21273/hortsci.46.1.86.
Pełny tekst źródłaProdhan, Shamsul H., K. Nagamiya, A. Komamine i H. Morishima. "EVALUATION OF TRANSGENIC INDICA RICE (Oryza sativa L.) THROUGH REPORTER AND DESIRED GENE". Bangladesh Journal of Plant Breeding and Genetics 20, nr 2 (31.12.2007): 11–16. http://dx.doi.org/10.3329/bjpbg.v20i2.17029.
Pełny tekst źródłaMcCallum, B. D., C. C. Bernier i L. Lamari. "Generation and utilization of chemical-resistant mutants in Pyrenophora tritici-repentis, the causal agent of tan spot of wheat". Canadian Journal of Botany 72, nr 1 (1.01.1994): 100–105. http://dx.doi.org/10.1139/b94-014.
Pełny tekst źródłaSultana, Shahanaz, Chai Ling Ho, Parameswari Namasivayam i Suhaimi Napis. "Genotypic differences in response to Hygromycin effect on untransformed calli death and rice germination". Bangladesh Rice Journal 18, nr 1-2 (17.04.2015): 38–43. http://dx.doi.org/10.3329/brj.v18i1-2.23001.
Pełny tekst źródłaPfister, P., M. Risch, D. E. Brodersen i E. C. Böttger. "Role of 16S rRNA Helix 44 in Ribosomal Resistance to Hygromycin B". Antimicrobial Agents and Chemotherapy 47, nr 5 (maj 2003): 1496–502. http://dx.doi.org/10.1128/aac.47.5.1496-1502.2003.
Pełny tekst źródłaMercuriani, Ixora Sartika, Aziz Purwantoro, Sukarti Moeljopawiro, Seonghoe Jang i Endang Semiarti. "Selection of Phalaenopsis amabilis L. Blume Orchid Resistance to Hygromycin". Indonesian Journal of Biotechnology 17, nr 2 (9.11.2015): 107. http://dx.doi.org/10.22146/ijbiotech.16000.
Pełny tekst źródłaMiao, V. P., M. R. Rountree i E. U. Selker. "Ectopic integration of transforming DNA is rare among neurospora transformants selected for gene replacement." Genetics 139, nr 4 (1.04.1995): 1533–44. http://dx.doi.org/10.1093/genetics/139.4.1533.
Pełny tekst źródłaDai, Qun, Zhihuan Sun i Guido Schnabel. "Development of Spontaneous Hygromycin B Resistance in Monilinia fructicola and Its Impact on Growth Rate, Morphology, Susceptibility to Demethylation Inhibitor Fungicides, and Sporulation". Phytopathology® 93, nr 11 (listopad 2003): 1354–59. http://dx.doi.org/10.1094/phyto.2003.93.11.1354.
Pełny tekst źródłaKo, Moon Kyung, Hyunchul Soh, Kyung-Moon Kim, Young Soon Kim i Kyunghoan Im. "Stable Production of Transgenic Pepper Plants Mediated by Agrobacterium tumefaciens". HortScience 42, nr 6 (październik 2007): 1425–30. http://dx.doi.org/10.21273/hortsci.42.6.1425.
Pełny tekst źródłaRozprawy doktorskie na temat "Hygromycine"
Ruggieri, Francesca. "Putting nature back into drug discovery : selection, design and synthesis of bioinspired chemical libraries for the discovery of new antibacterials". Electronic Thesis or Diss., Université de Lille (2022-....), 2024. http://www.theses.fr/2024ULILS013.
Pełny tekst źródłaNatural products (NPs) have declined in popularity since the introduction of synthetic small molecules several years ago. Many are the reasons behind this choice, such as difficulties in access and supply, complexities of NP chemistry and the advent of combinatorial chemistry. However, NPs offer many interesting properties compared to conventional synthetic molecules, which confer both advantages and challenges for the drug discovery process. Usually, NPs are characterized by a higher number of sp3 carbons and stereogenic centres, large scaffold diversity and structural complexity. With half of the drugs approved by the FDA since 1994 being NPs or hemisynthetic derivatives and the recent stagnation in new drug research and development, it is becoming more and more evident that NPs should be reintroduced in the drug discovery process as a source of inspiration.Therefore, many strategies are now emerging for the construction of nature-inspired chemical libraries, such as “top-down” and “bottom-up” strategies. In “bottom-up” approaches, complexity is created starting from simple building blocks. On the other hand, “top-down” approaches are assumed to make structural modifications to an already complex NP.Our presented work describes two different approaches to enrich the chemical library of our research unit with NP-derived compounds. A “top-down” semisynthetic strategy was planned to obtain derivatives of lactucin and 11β,13-dihydrolactucin, two sesquiterpene lactones extracted from chicory roots. Thirty-six ester derivatives were synthesized in three steps (classical synthesis), together with two amine derivative libraries (using parallel synthesis). All the compounds were then tested against Mycobacterium tuberculosis and some promising hits were found (MICGFP < 1.2 μM). On the other hand, a “bottom-up” strategy allowed the synthesis of two analogues of the known natural antibiotic hygromycin A. This approach started from simple commercially available building blocks and employed a dearomatization strategy in the synthetic process.Together, we explored a broader chemical space, increased the structural diversity of our chemical library and discovered new potential antibacterial hits. Moreover, this work paves the way for the discovery of new antibacterial targets
Hill, David G. "A stereoselective approach towards hygromycin A". Thesis, Heriot-Watt University, 1994. http://hdl.handle.net/10399/1354.
Pełny tekst źródłaKaminishi, Tatsuya, Andreas Schedlbauer, Attilio Fabbretti, Letizia Brandi, Lizarralde Borja Ochoa, Cheng-Guang He, Pohl Milon, Sean R. Connell, Claudio O. Gualerzi i Paola Fucini. "Crystallographic characterization of the ribosomal binding site and molecular mechanism of action of Hygromycin A". Oxford University Press, 2015. http://hdl.handle.net/10757/608247.
Pełny tekst źródłaBizkaia:Talent and the European Union's Seventh Framework Program (Marie Curie Actions; COFUND; to S.C., A.S., T.K.); Marie Curie Actions Career Integration Grant (PCIG14-GA-2013-632072 to P.F.); Ministerio de Economía Y Competitividad (CTQ2014-55907-R to P.F., S.C.); FIRB Futuro in Ricerca from the Italian Ministero dell'Istruzione, dell'Universitá e della Ricerca (RBFR130VS5_001 to A.F.); Peruvian Programa Nacional de Innovación para la Competitividad y Productividad (382-PNICP-PIBA-2014 (to P.M. and A.F.)). Funding for open access charge: Institutional funding.
Revisión por pares
McGaha, Susan Mabe. "Antibiotics that Inhibit 30S or 50S Ribosomal Subunit Formation: Hygromycin B, Quinupristin-Dalfopristin and XRP 2868". Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etd/2055.
Pełny tekst źródłaCordesman, Alexander. "MECHANICAL ABRASION AND ELECTROPORATION IN THE TRANSFORMATION OF INTACT PLEUROTUS OSTREATUS HYPHÆ and NUTRIENT-DEPENDANT RESISTANCE TO HYGROMYCIN B". VCU Scholars Compass, 2008. http://scholarscompass.vcu.edu/etd/173.
Pełny tekst źródłaChowdhury, Shukti Rani. "Establishment of regeneration and transient transformation systems for Australian native resurrection plant Tripogon loliiformis". Thesis, Queensland University of Technology, 2019. https://eprints.qut.edu.au/132682/1/Shukti%20Rani_Chowdhury_Thesis.pdf.
Pełny tekst źródłaLocken, Kristopher Michael. "Super hypersensitivity to hygromycin B (S-HHY) gene functions converge at the trans-golgi and late endosome interface have a role in tor1p location to the vacuole". Thesis, California State University, Long Beach, 2014. http://pqdtopen.proquest.com/#viewpdf?dispub=1527392.
Pełny tekst źródłaThe vacuole in Saccharomyces cerevisiae serves as a model for the mammalian lysosome. In a genome wide screen for mutants with severe growth hypersensitivity to hygromycin B, our lab identified 14 HHY genes. Each of the hhy mutants is defective in vacuolar trafficking and/or function and also sensitive to rapamycin and caffeine, suggesting a compromised target of rapamycin (TOR) kinase pathway. My research divides the hhy mutants into two groups based on quantitative growth analyses in the presence of hygromycin B. (1) a super affected group (s-hhy's) and (2) a dose-dependent group (d-hhy's). The s-HHY genes include CHC1, DRS2, SAC1, VPS1, VPS34, VPS45, VPS52, and VPS54. Evaluation of the known functions of s-HHY gene products reveals vesicular trafficking function at the trans-Golgi and late endosome interface to be a common factor. In yeast, the TORC1 complex localizes to the vacuole. Because a compromised TORC1 complex signaling is suggested in hhy mutant strains due to their caffeine or rapamycin sensitivity, I hypothesized that compromised TORC1 signaling in HHY's may be due to defects in the vacuolar localization of Tor1 kinase. To assess Tor1 kinase localization, we utilized a strain expressing endogenously tagged Tor1-GFP and assayed localization to the vacuolar membrane in each of the s-hhy mutants using confocal microscopy. In wild-type cells, Tor1-GFP co-localizes with the vacuolar membrane marker FM4-64 while s-hhy deletion strains fail to localize Tor1-GFP to the vacuolar membrane when treated with hygromycin B. Our results implicate that Tor1p is transported to the vacuole membrane via the late endosome (CPY pathway) and not the ALP (Vam3) pathway. Additionally, s-hhy mutants are unable to recover growth after a 4-hour treatment with hygromycin B, similar to EG0 mutants, which fail to exit from G0 after treatment with the TORC1 inhibiting drug rapamycin. Based on our data, we propose a model in which the s-HHY gene functions in vesicular trafficking at the trans-Golgi/late endosome interface are involved in recruitment and subsequent transport of Tor1p to the vacuolar membrane, and that interface is hypersensitive to hygromycin B. We also propose that Tor1 kinase localization at the vacuole is essential for its cell cycle regulatory function.
Dere, Madhavi Suresh. "Genetic Transformation of Switchgrass (Panicum Virgatum L.) with Endoglucanase Gene and Characterization of Plants with Endoglucanase Transgene". Thesis, Virginia Tech, 2012. http://hdl.handle.net/10919/76816.
Pełny tekst źródłaMaster of Science
Oliveira, Jonas Ivan Nobre. "Modelagem molecular na caracteriza??o eletr?nica de oligopept?deos e na descri??o qu?ntica da intera??o f?rmaco-receptor". Universidade Federal do Rio Grande do Norte, 2012. http://repositorio.ufrn.br:8080/jspui/handle/123456789/13075.
Pełny tekst źródłaCoordena??o de Aperfei?oamento de Pessoal de N?vel Superior
In this dissertation, the theoretical principles governing the molecular modeling were applied for electronic characterization of oligopeptide α3 and its variants (5Q, 7Q)-α3, as well as in the quantum description of the interaction of the aminoglycoside hygromycin B and the 30S subunit of bacterial ribosome. In the first study, the linear and neutral dipeptides which make up the mentioned oligopeptides were modeled and then optimized for a structure of lower potential energy and appropriate dihedral angles. In this case, three subsequent geometric optimization processes, based on classical Newtonian theory, the semi-empirical and density functional theory (DFT), explore the energy landscape of each dipeptide during the search of ideal minimum energy structures. Finally, great conformers were described about its electrostatic potential, ionization energy (amino acids), and frontier molecular orbitals and hopping term. From the hopping terms described in this study, it was possible in subsequent studies to characterize the charge transport propertie of these peptides models. It envisioned a new biosensor technology capable of diagnosing amyloid diseases, related to an accumulation of misshapen proteins, based on the conductivity displayed by proteins of the patient. In a second step of this dissertation, a study carried out by quantum molecular modeling of the interaction energy of an antibiotic ribosomal aminoglicos?dico on your receiver. It is known that the hygromycin B (hygB) is an aminoglycoside antibiotic that affects ribosomal translocation by direct interaction with the small subunit of the bacterial ribosome (30S), specifically with nucleotides in helix 44 of the 16S ribosomal RNA (16S rRNA). Due to strong electrostatic character of this connection, it was proposed an energetic investigation of the binding mechanism of this complex using different values of dielectric constants (ε = 0, 4, 10, 20 and 40), which have been widely used to study the electrostatic properties of biomolecules. For this, increasing radii centered on the hygB centroid were measured from the 30S-hygB crystal structure (1HNZ.pdb), and only the individual interaction energy of each enclosed nucleotide was determined for quantum calculations using molecular fractionation with conjugate caps (MFCC) strategy. It was noticed that the dielectric constants underestimated the energies of individual interactions, allowing the convergence state is achieved quickly. But only for ε = 40, the total binding energy of drug-receptor interaction is stabilized at r = 18A, which provided an appropriate binding pocket because it encompassed the main residues that interact more strongly with the hygB - C1403, C1404, G1405, A1493, G1494, U1495, U1498 and C1496. Thus, the dielectric constant ≈ 40 is ideal for the treatment of systems with many electrical charges. By comparing the individual binding energies of 16S rRNA nucleotides with the experimental tests that determine the minimum inhibitory concentration (MIC) of hygB, it is believed that those residues with high binding values generated bacterial resistance to the drug when mutated. With the same reasoning, since those with low interaction energy do not influence effectively the affinity of the hygB in its binding site, there is no loss of effectiveness if they were replaced.
Nessa disserta??o, os princ?pios te?ricos que regem a Modelagem Molecular foram aplicados na caracteriza??o eletr?nica do oligopept?deo α3 e seus variantes (5Q,7Q)-α3, como tamb?m na descri??o qu?ntica da intera??o do aminoglicos?deo higromicina B e a subunidade 30S do ribossomo bacteriano. No primeiro estudo, os dipept?deos lineares e neutros constituintes das biomol?culas mencionados foram modelados e posteriormente otimizados at? uma estrutura de menor energia potencial e ?ngulos diedros adequados. No caso, tr?s processos de otimiza??o geom?trica, baseados subsequentemente na teoria cl?ssica newtoniana, na semi-emp?rica e na teoria do funcional da densidade (DFT), varreram a paisagem de energia de cada dipept?deos na busca de uma estrutura de energia m?nima ideal. Por fim, os conf?rmeros ?timos foram descritos quanto ao potencial eletrost?tico, energia de ioniza??o (amino?cidos), orbitais de fronteira HOMO/HOMO-1 e termo de hopping. A partir dos termos de hopping descritos nesse trabalho, foi poss?vel, em estudos subsequentes, caracterizar as propriedades de transporte de cargas destes modelos pept?dicos. Vislumbra-se uma nova tecnologia de biosensores capaz de diagnosticar doen?as amiloides, relacionadas ao ac?mulo de pept?deos disformes, a partir do perfil de condutividade el?trica apresentado pelas prote?nas do paciente. Em um segundo momento dessa disserta??o, realiza-se um estudo qu?ntico por modelagem molecular da energia de intera??o de um antibi?tico aminoglicos?dico em seu receptor riboss?mico. Sabe-se que a higromicina B (higB) ? um antibi?tico aminoglicos?deo que afeta a transloca??o ribossomal pela intera??o direta com a subunidade menor do ribossomo bacteriano (30S), especificamente com nucleot?deos da h?lice 44 do RNA riboss?mico 16S (rRNA 16S). Devido ao forte car?ter eletrost?tico desta conex?o, foi proposta a investiga??o energ?tica do mecanismo de liga??o da higB no 30S usando diferentes valores de constantes diel?tricas (ε=0, 4, 10, 20 e 40), as quais s?o amplamente utilizadas no estudo das propriedades eletrost?ticas de biomol?culas. Para isso, foram medidos raios crescentes centralizados no centr?ide da higB tendo por base a estrutura cristalina higB-30S (1HNZ.pdb), e apenas a energia de intera??o individual de cada nucleot?deo englobado foi calculada quanticamente utilizando a estrat?gia de fracionamento molecular com capuzes conjugados (MFCC). Percebeu-se que as constantes diel?tricas subestimam as energias de intera??o individuais, permitindo que o estado de converg?ncia energ?tica seja alcan?ado rapidamente. Por?m apenas para ε=40, a energia de intera??o total droga-receptor se estabilizou em r=18?, o que se constituiu como um adequado s?tio de liga??o, pois englobou os res?duos do 16S que interagem mais fortemente com a higB - C1403, C1404, G1405, A1493, G1494, U1495, C1496 e U1498. Assim, a constante diel?trica ≈40 ? ideal para o tratamento de sistemas com muitas cargas. Confrontando as energias de liga??o individuais dos nucleot?deos 16SrRNA com ensaios experimentais para determina??o da concentra??o inibit?ria m?nima (MIC) da higB, acredita-se que esses res?duos com elevados valores de intera??o gerariam resist?ncia bacteriana ? droga quando mutados. Com o mesmo racioc?nio, visto que aqueles com baixa energia n?o influenciariam de forma eficaz a afinidade da higB em seu s?tio de liga??o, n?o ocorreria perda de efic?cia caso fossem substitu?dos.
Chen, Jong-Shenq, i 陳忠勝. "Transformation system of Trichoderma harzianum with the hygromycin B resistance gene, hph". Thesis, 1996. http://ndltd.ncl.edu.tw/handle/49887372835077302152.
Pełny tekst źródła國立中興大學
植物學系
84
Trichoderma harzianum was transformed with two different plasmids: pAN7-1 and pUCH1. Both plasmids carry hph gene ( encoding hygromycin B phosphotransferase) as the selectable marker. Transformation frequency were 124 and 77 transformants per ug DNA for pAN7-1 and pUCH1 respectively. In stability test, 30.3±3.7% conidia of pAN7-1 transformants was HygR and 34.8±3.4% for pUCH1 transformants. All transformants were stable after several subculture without any selective pressure. The stable transformants were analyzed by Southern hybridization, showed several copies of pAN7-1 were integrated into the chromosomes of stable transformants with non-homologous recombination, apparently at the same site in different transformants. There was no correlation between the growth and copy number in the pAN7-1 transformants.
Części książek na temat "Hygromycine"
Palaniappan, Nadaraj, i Kevin A. Reynolds. "Hygromycin A Biosynthesis". W ACS Symposium Series, 16–32. Washington, DC: American Chemical Society, 2007. http://dx.doi.org/10.1021/bk-2007-0955.ch002.
Pełny tekst źródłaSchomburg, Dietmar, i Dörte Stephan. "Hygromycin-B kinase". W Enzyme Handbook, 81–84. Berlin, Heidelberg: Springer Berlin Heidelberg, 1997. http://dx.doi.org/10.1007/978-3-642-59025-2_14.
Pełny tekst źródłaSchomburg, Dietmar, i Ida Schomburg. "hygromycin B 4-O-kinase 2.7.1.163". W Class 2–3.2 Transferases, Hydrolases, 371–80. Berlin, Heidelberg: Springer Berlin Heidelberg, 2013. http://dx.doi.org/10.1007/978-3-642-36240-8_84.
Pełny tekst źródłaHung, Chiung-Yu, Hua Zhang Wise i Garry T. Cole. "Gene Disruption in Coccidioides Using Hygromycin or Phleomycin Resistance Markers". W Host-Fungus Interactions, 131–47. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-539-8_9.
Pełny tekst źródłaZhang, Haiyan, i Jinjin Li. "From Cytosol to the Apoplast: The Hygromycin Phosphotransferase (HYGR) Model in Arabidopsis". W Unconventional Protein Secretion, 81–90. New York, NY: Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3804-9_5.
Pełny tekst źródłaGravelat, Fabrice N., David S. Askew i Donald C. Sheppard. "Targeted Gene Deletion in Aspergillus fumigatus Using the Hygromycin-Resistance Split-Marker Approach". W Host-Fungus Interactions, 119–30. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-539-8_8.
Pełny tekst źródłavan der Straten, A., H. Johansen, R. Sweet i M. Rosenberg. "Efficient Expression of Foreign Genes in Cultured Drosophila Melanogaster Cells Using Hygromycin B Selection". W Invertebrate and Fish Tissue Culture, 131–34. Berlin, Heidelberg: Springer Berlin Heidelberg, 1988. http://dx.doi.org/10.1007/978-3-642-73626-1_32.
Pełny tekst źródłaMajumder, Shuvobrata, Karabi Datta i Swapan Kumar Datta. "Agrobacterium tumefaciens-Mediated Transformation of Rice by Hygromycin Phosphotransferase (hptII) Gene Containing CRISPR/Cas9 Vector". W Methods in Molecular Biology, 69–79. New York, NY: Springer US, 2021. http://dx.doi.org/10.1007/978-1-0716-1068-8_5.
Pełny tekst źródłaNiklitschek, Mauricio, Marcelo Baeza, María Fernández-Lobato i Víctor Cifuentes. "Generation of Astaxanthin Mutants in Xanthophyllomyces dendrorhous Using a Double Recombination Method Based on Hygromycin Resistance". W Microbial Carotenoids From Fungi, 219–34. Totowa, NJ: Humana Press, 2012. http://dx.doi.org/10.1007/978-1-61779-918-1_15.
Pełny tekst źródłaPunt, Peter J., i Cees A. M. J. J. van den Hondel. "[39] Transformation of filamentous fungi based on hygromycin b and phleomycin resistance markers". W Methods in Enzymology, 447–57. Elsevier, 1992. http://dx.doi.org/10.1016/0076-6879(92)16041-h.
Pełny tekst źródłaStreszczenia konferencji na temat "Hygromycine"
Taipova, R. M., i B. R. Kuluev. "Agrobacterium-mediated transformation of Amaranthus cruentus L. epicotyls by the ARGOS-LIKE transgene". W 2nd International Scientific Conference "Plants and Microbes: the Future of Biotechnology". PLAMIC2020 Organizing committee, 2020. http://dx.doi.org/10.28983/plamic2020.244.
Pełny tekst źródłaSusiyanti, Winda Wati, Nurmayulis Nurmayulis, Sulastri Isminingsih i Sjaifuddin Sjaifuddin. "The Influence of Magnetic Fields Supply and Hygromycin Concentration to the Optimization of Folate Gene Putative Transformant Selection in Rice (cv. Fatmawati)". W 2nd and 3rd International Conference on Food Security Innovation (ICFSI 2018-2019). Paris, France: Atlantis Press, 2021. http://dx.doi.org/10.2991/absr.k.210304.046.
Pełny tekst źródłaRaporty organizacyjne na temat "Hygromycine"
Bostock, Richard M., Dov Prusky i Martin Dickman. Redox Climate in Quiescence and Pathogenicity of Postharvest Fungal Pathogens. United States Department of Agriculture, maj 2003. http://dx.doi.org/10.32747/2003.7586466.bard.
Pełny tekst źródłaPrusky, Dov, Noel T. Keen i Stanley Freeman. Elicitation of Preformed Antifungal Compounds by Non-Pathogenic Fungus Mutants and their Use for the Prevention of Postharvest Decay in Avocado Fruits. United States Department of Agriculture, styczeń 1996. http://dx.doi.org/10.32747/1996.7570573.bard.
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