Gotowe bibliografie tematyczne / Hydronephrosis

Gotowa bibliografia na temat „Hydronephrosis”

Autor: Grafiati
Data publikacji: 4 czerwca 2021
Data aktualizacji: 30 lipca 2024

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Artykuły w czasopismach na temat "Hydronephrosis"

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Das, Bhagwan, Kailash Kumar Daseja, Inayatullah ., Muhammad Rashid Rasul, Akhtar Hussain Phul i Imran Khan Memon. "Hydronephrotic Kidney Assessment via Ultrasonography". Pakistan Journal of Medical and Health Sciences 16, nr 6 (29.06.2022): 326–27. http://dx.doi.org/10.53350/pjmhs22166326.

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Objective: To assess hydronephrotic kidney assessment via ultrasonography. Study Design: Prospective study. Place and Duration of Study: Department of Radiology, Chandka Medical College Hospital, Larkana from 1st August 2020 to 31st September/2021. Methodology: Two hundred patients visited for the complaint and suspicion of hydronephrosis and within them 40 patients were diagnosed with hydronephrosis. The both kidneys were examined in the longitudinal as well as transvers planes of scanning using colored Doppler technique in ultrasonography. In older age patients a curved-array transducer having centered frequencies (3-6 MHz) was applied while in case of younger patients’ linear array-transducer was used with high entre frequencies. Results: The age of the patients was between 12-72 years with more elderly patients than youngsters. Most of the patients were males rather than females. Ureteropelvic obstruction in junction, primary megaureter as well as urethral valve involvement was observed in ultrasound imaging of hydronephrotic pediatric kidney. End stage hydronephrosis was presented in adult patients with cortical thining. Conclusion: Ureter and kidney stone appeared to be a common reason of hydronephrosis. Keywords: Hydronephrosis, Ultrasonography, Blockage, Calculi
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Arnold, Amy C., Hossam A. Shaltout, Shea Gilliam-Davis, Nancy D. Kock i Debra I. Diz. "Autonomic control of the heart is altered in Sprague-Dawley rats with spontaneous hydronephrosis". American Journal of Physiology-Heart and Circulatory Physiology 300, nr 6 (czerwiec 2011): H2206—H2213. http://dx.doi.org/10.1152/ajpheart.01263.2010.

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The renal medulla plays an important role in cardiovascular regulation, through interactions with the autonomic nervous system. Hydronephrosis is characterized by substantial loss of renal medullary tissue. However, whether alterations in autonomic control of the heart are observed in this condition is unknown. Thus we assessed resting hemodynamics and baroreflex sensitivity (BRS) for control of heart rate in urethane/chloralose-anesthetized Sprague-Dawley rats with normal or hydronephrotic kidneys. While resting arterial pressure was similar, heart rate was higher in rats with hydronephrosis (290 ± 12 normal vs. 344 ± 11 mild/moderate vs. 355 ± 13 beats/min severe; P < 0.05). The evoked BRS to increases, but not decreases, in pressure was lower in hydronephrotic rats (1.06 ± 0.06 normal vs. 0.72 ± 0.10 mild/moderate vs. 0.63 ± 0.07 ms/mmHg severe; P < 0.05). Spectral analysis methods confirmed reduced parasympathetic function in hydronephrosis, with no differences in measures of indirect sympathetic activity among conditions. As a secondary aim, we investigated whether autonomic dysfunction in hydronephrosis is associated with activation of the renin-angiotensin system (RAS). There were no differences in circulating angiotensin peptides among conditions, suggesting that the impaired autonomic function in hydronephrosis is independent of peripheral RAS activation. A possible site for angiotensin II-mediated BRS impairment is the solitary tract nucleus (NTS). In normal and mild/moderate hydronephrotic rats, NTS administration of the angiotensin II type 1 receptor antagonist candesartan significantly improved the BRS, suggesting that angiotensin II provides tonic suppression to the baroreflex. In contrast, angiotensin II blockade produced no significant effect in severe hydronephrosis, indicating that at least within the NTS baroreflex suppression in these animals is independent of angiotensin II.
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Carlström, Mattias, Russell D. Brown, Jenny Edlund, Johan Sällström, Erik Larsson, Tom Teerlink, Fredrik Palm, Nils Wåhlin i A. Erik G. Persson. "Role of nitric oxide deficiency in the development of hypertension in hydronephrotic animals". American Journal of Physiology-Renal Physiology 294, nr 2 (luty 2008): F362—F370. http://dx.doi.org/10.1152/ajprenal.00410.2007.

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Hydronephrotic animals develop renal injury and hypertension, which is associated with an abnormal tubuloglomerular feedback (TGF). The TGF sensitivity is coupled to nitric oxide (NO) in the macula densa. The involvement of reduced NO availability in the development of hypertension in hydronephrosis was investigated. Hydronephrosis was induced by ureteral obstruction in young rats. Blood pressure and renal excretion were measured in adulthood, under different sodium conditions, and before and after chronic administration of either NG-nitro-l-arginine methyl ester (l-NAME) or l-arginine. Blood samples for ADMA, SDMA, and l-arginine analysis were taken and the renal tissue was used for histology and determination of NO synthase (NOS) proteins. TGF characteristics were determined by stop-flow pressure technique before and after administration of 7-nitroindazole (7-NI) or l-arginine. Hydronephrotic animals developed salt-sensitive hypertension, which was associated with pressure natriuresis and diuresis. The blood pressure response to l-NAME was attenuated and l-arginine supplementation decreased blood pressure in hydronephrotic animals, but not in the controls. Under control conditions, reactivity and sensitivity of the TGF response were greater in the hydronephrotic group. 7-NI administration increased TGF reactivity and sensitivity in control animals, whereas, in hydronephrotic animals, neuronal NOS (nNOS) inhibition had no effect. l-Arginine attenuated TGF response more in hydronephrotic kidneys than in controls. The hydronephrotic animals displayed various degrees of histopathological changes. ADMA and SDMA levels were higher and the renal expressions of nNOS and endothelial NOS proteins were lower in animals with hydronephrosis. Reduced NO availability in the diseased kidney in hydronephrosis, and subsequent resetting of the TGF mechanism, plays an important role in the development of hypertension.
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Carlström, Mattias, Russell D. Brown, Johan Sällström, Erik Larsson, Mihkel Zilmer, Sheller Zabihi, Ulf J. Eriksson i A. Erik G. Persson. "SOD1 deficiency causes salt sensitivity and aggravates hypertension in hydronephrosis". American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 297, nr 1 (lipiec 2009): R82—R92. http://dx.doi.org/10.1152/ajpregu.90843.2008.

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Hydronephrosis causes renal dysfunction and salt-sensitive hypertension, which is associated with nitric oxide deficiency and abnormal tubuloglomerular feedback (TGF) response. We investigated the role of oxidative stress for salt sensitivity and for hypertension in hydronephrosis. Hydronephrosis was induced in superoxide dismutase 1-transgenic (SOD1-tg), SOD1-deficient (SOD1-ko), and wild-type mice and in rats. In mice, telemetric measurements were performed during normal (0.7% NaCl) and high-sodium (4% NaCl) diets and with chronic tempol supplementation. The 8-iso-prostaglandin-F2α (F2-IsoPs) and protein excretion profiles and renal histology were investigated. The acute effects of tempol on blood pressure and TGF were studied in rats. In hydronephrosis, wild-type mice developed salt-sensitive hypertension (114 ± 1 to 120 ± 2 mmHg), which was augmented in SOD1-ko (125 ± 3 to 135 ± 4 mmHg) but abolished in SOD1-tg (109 ± 3 to 108 ± 3 mmHg). SOD1-ko controls displayed salt-sensitive blood pressure (108 ± 1 to 115 ± 2 mmHg), which was not found in wild types or SOD1-tg. Chronic tempol treatment reduced blood pressure in SOD1-ko controls (−7 mmHg) and in hydronephrotic wild-type (−8 mmHg) and SOD1-ko mice (−16 mmHg), but had no effect on blood pressure in wild-type or SOD1-tg controls. SOD1-ko controls and hydronephrotic wild-type and SOD1-ko mice exhibited increased fluid excretion associated with increased F2-IsoPs and protein excretion. The renal histopathological changes found in hydronephrotic wild-type were augmented in SOD1-ko and diminished in SOD-tg mice. Tempol attenuated blood pressure and normalized TGF response in hydronephrosis [ΔPSF: 15.2 ± 1.2 to 9.1 ± 0.6 mmHg, turning point: 14.3 ± 0.8 to 19.7 ± 1.4 nl/min]. Oxidative stress due to SOD1 deficiency causes salt sensitivity and plays a pivotal role for the development of hypertension in hydronephrosis. Increased superoxide formation may enhance TGF response and thereby contribute to hypertension.
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Vari, R. C., F. G. Boineau i J. E. Lewy. "Angiotensin or thromboxane receptor antagonism in rats with congenital hydronephrosis." Journal of the American Society of Nephrology 3, nr 8 (luty 1993): 1522–29. http://dx.doi.org/10.1681/asn.v381522.

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A technique for the measurement of GFR without collection of urine in rats was experimentally validated and applied to experiments designed to: (1) evaluate the degree of reduction of GFR in rats with congenital, unilateral hydronephrosis; and (2) to determine if the reduction in renal function is mediated by angiotensin II and/or thromboxane A2 mechanisms. Simultaneous measurements of GFR by a constant-infusion technique and the traditional inulin clearance technique in rats with either one or two normal kidneys were highly correlated (r = 0.934; P < 0.001; N = 17). GFR was approximately 24% lower (P < 0.001) in rats with congenital unilateral hydronephrosis than in rats with a normal kidney. The GFR in rats with hydronephrosis infused with a receptor blocker for either angiotensin II or thromboxane A2 was greater than the GFR in hydronephrotic kidneys without blockade and was not significantly different (P > 0.05) from that in rats with normal kidneys. These results indicate that a constant inulin infusion technique without urine collections can be used to accurately measure GFR in congenitally hydronephrotic kidneys, rendering values free from possible residual pelvic volume artifact. In addition, these results also indicate that a significant 24% reduction in GFR occurs in congenital unilateral hydronephrosis and is mediated by angiotensin II and thromboxane A2 mechanisms.
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Otero, Hansel J., Juan J. Cerrolaza, Judyta Loomis, Amanda George, Elijah Biggs, James Jago i Marius G. Linguraru. "Feasibility and Quality Determinants of 3D Sonography in Children With Hydronephrosis". Journal of Diagnostic Medical Sonography 34, nr 1 (24.07.2017): 31–36. http://dx.doi.org/10.1177/8756479317717201.

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The objective was to determine the image quality of 3D diagnostic medical sonography (DMS) in children with hydronephrosis. 3D DMS was assessed based on 24 pediatric patients. Image quality was evaluated by two radiologists and a sonographer in terms of rib shadowing, cut-off parenchymal edges, motion artifact, and overall quality. The interreader reliability and relation between image quality and other variables were calculated. The results were based on images of 32 hydronephrotic kidneys. The average quality scoring of the images was quite high. Rib shadowing, cut-off edges, and motion artifact were present in the majority of the cases. The interreader reliability for overall quality, rib shadowing, cut-off, and motion was quite high. There was a correlation between the Society for Fetal and Neonatal Urology’s hydronephrosis grade and higher cut-off edges. Larger kidneys were more likely to show cut-off, motion, and lower quality scores. In this cohort of infants and toddlers with hydronephrotic kidneys, 3D DMS demonstrated good image quality; however, artifacts were attributed to kidney size and severity of hydronephrosis.
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Takeda, M., Y. Katayama, T. Tsutsui, T. Komeyama i T. Mizusawa. "Dynamic Magnetic Resonance Imaging of Hydronephrosis using Low Magnetic Field Apparatus. Comparison with Radionuclide Study". Urologia Journal 60, nr 4 (sierpień 1993): 338–44. http://dx.doi.org/10.1177/039156039306000410.

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We evaluated the value of dynamic magnetic resonance imaging (MRI) under low magnetic field in estimating functional recovery from hydronephrosis by comparing dynamic MRI using a low-magnetic field machine with radioisotope (Rl) renal scintigraphy. 1) Both in normal kidney and hydronephrosis, patterns of dynamic MRI were different from those of 99mTc-diethylene triamine pentaacetic acid renography in most cases. 2) The ratio of signal intensity of renal medulla (or inner parenchyma) and that of renal cortex (or outer parenchyma) at the 3rd image tended to be correlated with the grade of hydronephrosis on intravenous pyelography. 3) When signal intensity of renal cortex (or outer parenchyma) increased from the 1st to the 2nd image more rapidly than that of renal medulla (or inner parenchyma), improvement of function of the hydronephrotic kidney after release of obstruction could be expected according to the change in 99mTc-dimercaptosuccinic acid renal uptake rate. In conclusion, dynamic MRI using a low magnetic field machine may predict functional recovery from hydronephrosis.
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Krivoshei, Lian, Yemi Akin-Olugbade, Glen Mcwilliams, Moshe Halak i Daniel Silverberg. "Endovascular repair of an abdominal aortic aneurysm in the presence of a hydronephrotic horseshoe kidney". Vascular 20, nr 1 (luty 2012): 54–56. http://dx.doi.org/10.1258/vasc.2011.cr0298.

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The aim of this paper is to report an unusual case of a patient with an abdominal aortic aneurysm (AAA) and a hydronephrotic horseshoe kidney (HSK) that was repaired by endovascular means. An 81-year-old male patient with a known HSK was found to have hydronephrosis and an AAA. The patient's aneurysm was treated with an endovascular stent graft which required the covering of accessory renal arteries. He had an uneventful recovery with complete resolution of the hydronephrosis evident on a computed tomography scan performed seven months after the surgery. In conclusion, endovascular aneurysm repair is a feasible therapeutic option for an AAA coexisting with an HSK and may be considered as a valid alternative to open repair when concomitant hydronephrosis is present.
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Venkatesan, Krishnan, Joel Green, Steven R. Shapiro i George F. Steinhardt. "Correlation of Hydronephrosis Index to Society of Fetal Urology Hydronephrosis Scale". Advances in Urology 2009 (2009): 1–4. http://dx.doi.org/10.1155/2009/960490.

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Purpose. We seek to correlate conventional hydronephrosis (HN) grade and hydronephrosis index (HI).Methods. We examined 1207 hydronephrotic kidneys by ultrasound. HN was classified by Society of Fetal Urology guidelines. HN was then gauged using HI, a reproducible, standardized, and dimensionless measurement of renal area. We then calculated average HI for each HN grade.Results. Comparing HI to standard SFU HN grade, average HI is 89.3 for grade I; average HI is 83.9 for grade II; average HI is 73.0 for grade III; average HI is 54.6 for SFU grade IV.Conclusions. HI correlates well with SFU HN grade. The HI serves as a quantitative measure of HN. HI can be used to track HN over time. Versus conventional grading, HI may be more sensitive in defining severe (grades III and IV) HN, and in indicating resolving, stable, or worsening HN, thus providing more information for clinical decision-making and HN management.
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Medjebeur, A. A., L. Bussieres, B. Gasser, V. Gimonet i K. Laborde. "Experimental bilateral urinary obstruction in fetal sheep: transforming growth factor-beta 1 expression". American Journal of Physiology-Renal Physiology 273, nr 3 (1.09.1997): F372—F379. http://dx.doi.org/10.1152/ajprenal.1997.273.3.f372.

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To gain insight into the role of transforming growth factor-beta 1 (TGF-beta 1) in the development of kidney pathology following fetal obstruction, we measured TGF-beta 1 gene expression, the active peptide, and the urinary concentration in a model of fetal bilateral urinary obstruction (BUO) in sheep. Fetal lambs underwent BUO at 60 (FO-60) or 80 days (FO-80) of gestation and were studied at 120 days. Independently of the onset or duration of obstruction, all fetuses developed type IV dysplasia (IV) associated with an arrest in the nephrogenesis or hydronephrosis. Fetal glomerular filtration rate was not significantly modified, whereas sodium tubular reabsorption was significantly decreased, and urinary TGF-beta 1 concentration was elevated in hydronephrosis but not in IV. Levels of TGF-beta 1 mRNA were increased in hydronephrosis compared with normal kidneys, and active TGF-beta 1 immunoreactivity was increased in both hydronephrotic and IV kidneys. In summary, TGF-beta 1 may play a role in the development of hydronephrosis and dysplasia in kidneys following fetal BUO. Its role in the arrest of nephrogenesis observed in the IV kidneys remains to be proved.
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Rozprawy doktorskie na temat "Hydronephrosis"

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Carlström, Mattias. "Development of Salt-Sensitive Hypertension in Hydronephrosis". Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8586.

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Hydronephrosis, due to ureteropelvic junction obstruction, is a common condition in infants with an incidence of approximately 0.5-1%. During the last decade, the surgical management of non-symptomatic hydronephrosis has become more conservative, and the long-term physiological consequences of this new policy are unclear. The overall aim of this thesis was to determine whether there is a link between hydronephrosis and the development of hypertension. Hydronephrosis was induced by partial ureteral obstruction in 3-week old rats or mice. In the adult animals, blood pressure was measured telemetrically during different sodium conditions and the renal function was evaluated. Both species developed salt-sensitive hypertension and histopathological changes (i.e. fibrosis, inflammation, glomerular and tubular changes) that correlated with the degree of hydronephrosis. An abnormal renal excretion pattern with increased diuresis and impaired urine concentrating ability was observed in hydronephrosis. The mechanisms were primarily located to the diseased kidney, as relief of the obstruction attenuated blood pressure and salt-sensitivity. Increased renin angiotensin system activity, due to ureteral obstruction, might be involved in the development but not necessary the maintenance of hypertension. Hydronephrotic animals displayed reduced nitric oxide availability, which might be due to increased oxidative stress in the diseased kidney. Renal nitric oxide deficiency and subsequent resetting of the tubuloglomerular feedback mechanism, appeared to have an important role in the development of hypertension. In conclusion, experimental hydronephrosis, induced by partial ureteral obstruction, provides a new model for studies of salt-sensitive hypertension. Furthermore, the new findings imply that the current conservative treatment strategy in hydronephrosis should be reconsidered in favour of treatment that is more active, in order to prevent the development of renal injury and hypertension in later life.

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Samnakay, Naeem. "Antenatal bladder outflow obstruction : effects of morphology and apoptosis in the fetal kidney, and effects on fetal ACTH and cortisol levels in an ovine model". University of Western Australia. School of Women's and Infants' Health, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0151.

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Posterior urethral valves cause bladder outflow obstruction and damage to the developing fetal kidney. Posterior urethral valves affect 1 in 8000 new-born males. A third of these children develop end stage renal failure by adolescence, despite valve ablation in the early post-natal period, implying that majority of the damage to the kidneys occurs in utero. How does this damage occur, and should we intervene in utero? The answers to these questions require further research, and are the basis to this thesis. This thesis focused on the effect bladder outflow obstruction has on morphology and apoptosis in the fetal kidney in a fetal lamb model. It also looked at the effect of bladder outflow obstruction on fetal stress hormone levels. Bladder outflow obstruction was created surgically in fetal lambs at day 70 of gestation, and fetal kidneys were analysed at day 2, 5, 10, 20 and 30 after creation of obstruction. Controls undergoing sham surgery were used for comparison. Four aspects were investigated: - effects of bladder outflow obstruction on renal histology effects of bladder outflow obstruction on expression of pro-apoptosis gene Bax and anti-apoptosis gene Bcl-X - effects of bladder outflow obstruction on renal regional apoptosis effects of bladder outflow obstruction on serum fetal ACTH and cortisol levels. Bladder outflow obstruction resulted in sequential morphological change in the fetal kidney over time. By 2 days post-obstruction, cystic change was noted. In addition, patchy attenuation of the nephrogenic blastema was evident by 5 days post-obstruction, with more confluent blastemal attenuation as well as generalized renal architectural disorganization by 10 days post-obstruction. By 20 and 30 days post-obstruction, cystic renal dysplasia had developed. Bladder outflow obstruction resulted in an increase in the ratio of renal expression of pro-apoptosis gene Bax to anti-apoptosis gene Bcl-X. Regional apoptosis counts showed increased tubular apoptosis compared to controls at 2 days post-obstruction, and increased blastemal apoptosis compared to controls at 5 days post-obstruction. By 10 days post-obstruction, blastemal apoptosis counts were reduced compared to controls. There were no significant differences in fetal serum ACTH and cortisol levels between fetal lambs with bladder outflow obstruction and controls. In conclusion, the results of this thesis outline the spectrum of morphological change in the fetal kidney over 30 days of bladder outflow obstruction. They show that detectable changes in morphology occur within two days of bladder outflow obstruction. Likewise, detectable changes in gene expression occur within 2 days of bladder outflow obstruction. The increased ratio of expression of Bax to Bcl-X suggests a swing towards increased apoptosis in response to bladder outflow obstruction. Further research is required to ascertain if these changes are reversible. However, the early onset of these changes as shown in this thesis suggests that any fetal intervention to protect the fetal kidney from the effects of bladder outflow obstruction may need to be instituted very early in gestation
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Pegolo, Patrícia Traballi de Carvalho 1978. "Aferição da pressão anterógrada do trato urinário alto em crianças com hidronefrose pós-operatória persistente = Antegrade pressure measurement of the upper urinary tract in children with postoperative persistent hydronephrosis". [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310692.

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Orientadores: Márcio Lopes Miranda, Joaquim Murray Bustorff Silva
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-23T05:54:16Z (GMT). No. of bitstreams: 1 Pegolo_PatriciaTraballideCarvalho_M.pdf: 8691272 bytes, checksum: f031f75f0c905eb91023315f2a724479 (MD5) Previous issue date: 2013
Resumo: Introdução: A dilatação do trato urinário pode existir sem a presença de obstrução. Os métodos diagnósticos dependentes da função renal podem suscitar diagnósticos equivocados. Whitaker (1973) propôs a avaliação da pressão do trato urinário submetida a um fluxo constante. Outros investigadores propuseram a perfusão da pelve renal sob pressão controlada, tornando o método mais fisiológico e reprodutível. Este estudo tem o objetivo de avaliar os resultados da aferição da pressão anterógrada do trato urinário alto (APA) em crianças com hidronefrose persistente pós-operatória e com suspeita de obstrução. Pacientes e Métodos: No período de doze anos, 26 unidades renais com hidronefrose persistente pós-operatória (12 anomalias da junção pieloureteral-JUP e 14 anomalias da junção ureterovesical-JUV), foram submetidas à avaliação da pressão do trato urinário alto para a orientação da conduta. As cintilografias renais dinâmicas (CRD), urografias excretoras (UE) e ultrassonografias (US) prévias, foram consideradas como indeterminadas para obstrução em 10 ocasiões e obstrutivas em 16. A APA foi realizada por punção da pelve renal sob radioscopia ou via estoma confeccionado previamente. Procedeu-se a infusão de solução salina com azul de metileno mais contraste iodado, sob pressão constante de 40cm de água para preenchimento do sistema urinário, aferindo-se a pressão de abertura ureteral a partir da drenagem do sistema e estabilização da coluna d'água. Resultados: Dentre os dez testes com diagnósticos prévios indeterminados, dois foram considerados não obstrutivos após a APA e tratados conservadoramente. Oito foram considerados obstrutivos e reoperados. Dos dezesseis testes classificados como obstrutivos previamente, nove confirmaram obstrução e foram submetidos à cirurgia. Sete foram considerados não obstrutivos, tratados conservadoramente e mantiveram hidronefrose e DMSA estáveis. Conclusão: A APA evitou cirurgia desnecessária em um terço dos casos e orientou o procedimento em 100%. Acreditamos que este teste simplificado é uma opção diagnóstica, quando utilizada seletivamente e principalmente, na presença de déficit funcional
Abstract: Introduction: The dilation of the urinary tract can exist even without obstruction. The diagnostic methods that depend on renal function may give rise to misdiagnosis. Whitaker (1973) proposed the evaluation of the urinary tract pressure subjected to a steady flow. Other researchers have proposed the perfusion of the renal pelvis under controlled pressure, making the method most physiological and reproducible. The aim of this study is evaluate the results of antegrade pressure measurements of the upper urinary tract (APA) in children with persistent hydronephrosis with suspected postoperative obstruction. Patients and Methods: During twelve years, 26 renal units with persistent postoperative hydronephrosis (12 JUP and 14 JUV), underwent pressure evaluation of the urinary tract to guide the patient management. The previous scintigraphy (DTPA), intravenous pyelography and ultrasonography were considered indeterminate for obstruction on 10 times and obstructive in 16. The APA was performed by puncture of the renal pelvis under fluoroscopy or by stoma previously performed. After accessing the renal pelvis, infusion of a mix of saline, methylene blue and contrast medium was performed, under constant pressure of 40cm of water, filling the urinary tract. Measurements of the uretheral opening pressure were taken after the water column was stabilized. Results: Often cases that had a previous undetermined diagnostics, after APA test, two cases were considered non-obstructive and had a conservative treatment. Eight tests were considered obstructive and the patients had a re-do operation. Of sixteen cases previously classified as obstructive, nine units showed obstruction on APA test and these patients underwent to a new operation. The remaining 7 units were considered non-obstructive and treated conservatively, with stable hydronephrosis and DMSA in the follow up. Conclusion: The APA test guided all patient management and avoided unnecessary surgical intervention in one third of these cases. We believe that this simplified test is a diagnostic option when used selectively and mainly in the presence of poor renal function
Mestrado
Fisiopatologia Cirúrgica
Mestra em Ciências
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MIYAKE, KOJI, HATSUKI HIBI i MASANORI YAMAMOTO. "A CASE OF UNILATERAL GIANT HYDRONEPHROSIS WITH RENAL INSUFFICIENCY". Nagoya University School of Medicine, 1995. http://hdl.handle.net/2237/16085.

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Kato, Kazuo, Chiemi Haneda i Mutsushi Matsuyama. "CONGENIC STRAIN DIFFERENCES OF RENAL MALFORMATIONS IN ACI/MNA RATS BY INTROGRESSION OF THE CHROMOSOMAL REGION OF BUF/MNA RATS CONTAINING PUR1". Nagoya University School of Medicine, 2013. http://hdl.handle.net/2237/18474.

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Bernardes, Lisandra Stein. "Análise da vascularização renal ao Power Doppler tridimensional em fetos com dilatação de vias urinárias: correlação com prognóstico renal pós-natal". Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5139/tde-18022011-124911/.

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INTRODUÇÃO: Não há, até o momento, método ideal de avaliação da função renal em fetos com dilatação de vias urinárias. A ultrassonografia é utilizada como um método não invasivo e alguns parâmetros, como o índice de líquido amniótico, foram descritos na predição de insuficiência renal. Entretanto, a sensibilidade é baixa e a detecção de alterações, muitas vezes, ocorre tardiamente na gestação. A avaliação bioquímica da urina ou sangue fetais acrescenta risco à gestação e, apesar de melhorar a detecção de insuficiência renal, tem sensibilidade e especificidade baixas. O Power Doppler tridimensional é um método capaz de quantificar fluxo em órgãos parenquimatosos e tem sido utilizado na quantificação de fluxo sanguíneo de órgãos fetais e placenta. Como fetos com obstrução de vias urinárias e insuficiência renal apresentam diminuição no número de glomérulos, a quantificação do fluxo renal ao Power Doppler tridimensional poderia aprimorar a avaliação da função renal desses fetos. OBJETIVOS: quantificar o fluxo renal ao Power Doppler tridimensional em fetos com suspeita de obstrução de vias urinárias e naqueles com morfologia renal normal, avaliar a influência da profundidade nos índices vasculares e comparar os índices nos fetos que evoluíram com e sem insuficiência renal no período pós-natal. MÉTODOS: fetos com hidronefrose bilateral e/ou dilatação vesical foram prospectivamente comparados com fetos sem malformações em relação à quantificação do fluxo renal ao Power Doppler tridimensional. Os parâmetros avaliados foram IV, IVF, IF e a profundidade. Após o nascimento, as crianças foram seguidas por uma equipe de nefrologia e urologia e, de acordo com a função renal, foram classificadas em 2 grupos: insuficiência renal e função renal normal. A vascularização renal foi avaliada em cada grupo e comparada ao grupo controle. RESULTADOS: vinte e três fetos com dilatação de vias urinárias e setenta e três com morfologia renal normal foram considerados para a análise estatística. Cinco crianças (21,7%) apresentaram insuficiência renal após o nascimento. IV e IVF foram significativamente mais baixos nos casos que apresentaram insuficiência renal do que naqueles com função renal normal (p=0,009 e 0,036, respectivamente). Os três índices corrigidos pela profundidade (IVCP, IFCP e IVFCP) variaram com a idade gestacional e a variação inter-observador melhorou quando eles foram utilizados. A porcentagem do IVCP e do IVFCP em relação à controles de mesma idade gestacional foi menor nos casos que desenvolveram insuficiência renal do que naqueles que evoluíram com função renal normal. CONCLUSÕES: IV e IVF foram significativamente mais baixos em fetos que evoluíram com insuficiência renal pósnatal, porém a profundidade foi um fator interferente importante. Desta forma, IVCP e IVFCP são potencialmente melhores na avaliação de fetos com suspeita de obstrução de vias urinárias. Como os índices corrigidos pela profundidade variam de acordo com a idade gestacional, é necessária a construção de curvas de normalidade por idade gestacional para que os referidos índices possam ser avaliados na prática clínica
INTRODUCTION: There is no ideal method for prenatal evaluation of renal function whether there is a urinary tract dilatation in the fetus. Although ultrasound is a noninvasive method and some parameters have been described to evaluate fetal renal function, as amniotic fluid index, there is a lack of sensitivity to renal failure when ultrasound is used alone. Furthermore, ultrasound changes may appear late in pregnancy. Biochemical evaluation of fetal urine or blood may expose the fetus to some risk, and still lack sensitivity and specificity for renal failure. Threedimensional Power Doppler evaluation has been used to quantify blood flow in fetal organs and placenta. As urinary tract obstruction lead to decrease in renal glomeurli and consequently to a decrease in parenchymal renal flow, three-dimensional quantification of renal flow may improve the evaluation of fetal renal function in fetuses with renal dilatation. OBJECTIVES: To evaluate the ability of threedimensional evaluation of renal vascularization to predict postnatal renal prognosis in fetuses with suspicion of urinary obstruction and to analyze depth influence in vascular indexes. METHODS: Fetuses with bilateral hydronephrosis and/or bladder dilatation had renal vascularization evaluated by three-dimensional ultrasound and VOCAL and were prospectively compared to healthy fetuses. Parameters evaluated were VI, VFI, FI and the distance between the probe and the renal cortex. Follow up by urologists and nephrologists allowed us to allocate these fetuses in two groups: renal impairment and normal renal function. Renal vascularization was evaluated in each group and compared to controls. RESULTS: Twenty-three fetuses with urinary dilatation and seventy-three fetuses with normal renal morphology where considered for statistical analysis. Five fetuses (21,7%) developed renal impairment. VI and VFI where significantly lower in fetuses that developed renal impairment than in those with normal renal function (p=0.009 and 0.036 respectively). Depth-corrected indexes (VIDC, FIDC and VFIDC) varied with gestational age and inter-observer variability was improved when depth was taken into account. The percentage of VIDC and VFIDC of cases in relation to gestational aged matched controls were lower in fetuses that developed post-natal renal impairment than in fetuses with normal renal function. CONCLUSION: Although VI and VFI were significantly lower in fetuses that developed post-natal renal impairment, depth seemed to be an important confounding variable. Thus, VIDC and VFIDC were potentially useful in this context. However, since depth-corrected indexes are related to gestational age, nomograms are needed to further evaluate the role of these parameters in predicting renal impairment
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More, Stuart Setjhaba. "Renal Cortical Transit time as a predictor for pyeloplasty in paediatric patients with unilateral hydronephrosis at the Red Cross War Memorial Children's Hospital". Master's thesis, Faculty of Health Sciences, 2018. http://hdl.handle.net/11427/30166.

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Background: Majority of patients with unilateral hydronephrosis (HN) detected on ultrasound (US) do not require pyeloplasty. Indications for pyeloplasty are in patients with symptomatic obstruction (recurrent flank pain), complications such as urinary tract infection, a drop in differential renal function (DRF) of more than 10% and a progressive increase in the anterior posterior diameter (APD) in subsequent studies. Schlotmann et al, Piepsz et al and Harper et al have demonstrated the measurement of the cortical transit time (CTT) to predict the need for patient who may require pyeloplasty. Objectives: To assess if the CTT would have predicted a drop in DRF in patients with unilateral HN on the affected side. In addition to assess whether the CTT would differ on the first renogram between those patients who had a pyeloplasty and those who did not have a pyeloplasty at the Red Cross War Memorial Children’s Hospital (RCWMCH). Methods: Sixty eight (68) patients with at least two renograms with unilateral HN with a normal contralateral kidney were observed retrospectively between December 2000 and May 2015. The CTT was recorded for the upper, middle and lower third of each kidney and the mean used as the CTT of the kidney. Each renogram was processed three times to measure the DRF using the Rutland Patlak and Integral methods. The mean of the three DRF measurements was used for analysis. Results: The mean CTT of the left and right hydronephrotic kidneys were 6.0minutes and 6.7minutes respectively. A significant relationship was demonstrated in the CTT and DRF as well as CTT and APD in the first renogram of those patients who did not have a pyeloplasty (p < 0.05). There was no difference between the DRF of the first and second renograms in those patients who did not have a pyeloplasty. In the 20 patients who had a pyeloplasty, there was a drop of more than 10% in the DRF of 3 patients. No difference was seen in the DRF or in the CTT between the first and second renogram. The CTT was shorter in the second renogram in 9 of the 20 patients who had a pyeloplasty. No significant difference was found in the CTT or DRF when comparing the group who had surgery against the group who did not have surgery. Conclusion: The current study was unable to demonstrate in our series of patients that CTT can predict those patients who would require pyeloplasty. This may be owing to the retrospective nature of the study and the reliance on the clinical notes for the US data and surgical notes. In future, a prospective study evaluating the relationship between CTT and a drop in the DRF should be undertaken in this unit.
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Bertti, Rodolfo Otávio Tomaz 1974. "Modelo experimental de obstrução ureteral em coelhos". [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310675.

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Orientadores: Marcelo Lopes de Lima, Carlos Arturo Levi D¿Ancona
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-19T16:54:01Z (GMT). No. of bitstreams: 1 Bertti_RodolfoOtavioTomaz_M.pdf: 2337476 bytes, checksum: aee22920cef52ff73befdaef0207e2f7 (MD5) Previous issue date: 2011
Resumo: A estenose da junção pieloureteral (JUP) é uma das anomalias congênitas mais frequentes. Clinicamente, pode se manifestar por infecção do trato urinário, por dor e pela perda da função renal. Portanto, o estudo desta doença é importante para se determinar a melhor forma tratamento. O objetivo deste trabalho foi criar um modelo experimental de estenose ureteral. Dez coelhas da raça New Zealand foram estudadas, com idade de três meses e peso aproximado de 3,5kg. Através de laparotomia e abordagem do retroperitôneo, um segmento do ureter esquerdo foi introduzido no músculo psoas ipsilateral de forma padronizada. O lado direto funcionou como controle. Um mês após a cirurgia, os animais foram submetidos a estudo renal cintilográfico com o ácido dietilenotriaminopentacético marcado com 99mTc (DTPA-99mTc). Em seguida, os animais foram submetidos à eutanásia e as peças (rins e ureteres) retiradas para análise histológica. O estudo cintilográfico demonstrou que sete unidades renais esquerdas apresentaram padrão de obstrução ureteral. A porcentagem de excreção após a administração de furosemida variou de 1 +/- 74% para DTPA-99mTc, apresentando uma diferença estatisticamente significante (p<0,05). No estudo anatomopatológico, concluiu-se que os rins e ureteres mantinham hidronefroses leves em dois e moderadas em sete animais, caracterizando diagnóstico de obstrução em nove coelhas (90%). Houve, também, discreto processo inflamatório e ausência de fibrose no segmento ureteral introduzido no músculo psoas. A técnica experimental de obstrução ureteral criou um modelo de hidronefrose em coelhos
Abstract: The stenosis of the ureteropelvic junction (UPJ) is one of the most frequent congenital anomalies and are clinically important to be treated not only for the quality of life that gets worse, pain and urinary tract infection, but also the loss of the kidney function (1,2,3). So, the study of UPJ model will be used for future treatment. The aim of this study was to create an experimental model of ureteral obstruction in rabbits. The sample of this project was composed by a number of ten female rabbits from New Zealand, three months old, weighing about 3.5kg. An intra-peritoneal medium laparatomy was made, pushing the abdominal organs in order to have a large access to the retroperitoneal. The studies consist of creating an experimental ureteral obstruction model through the introduction of its segment inside the psoas ipsilateral muscle in a standard way. The right side was used as the control. After one month, the rabbits were underwent the intravenous injection of 99mTc-DTPA. After the diuretic renogram analysis was realized, the animal was sacrificed end the removed parts, kidneys and ureters were submited histological analysis. The study showed that seven left kidneys presented obstruction. The excretion after furosemide injection was 1 ± 74% for 99mTc-DTPA, with a statistically significant difference between both renal (p<0.05). In the anatomopathological study, two animals were classified as light and seven as moderate obstruction, characterizing diagnosis of obstruction in nine rabbits (90%). The lack of an inflammatory process and fibrosis in the circumvolution location was observed. The experimental technique of ureteral obstruction created a model of hydronephrosis in rabbits
Mestrado
Cirurgia
Mestre em Cirurgia
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Kostic, Dusan. "Biomarcadores para diagnóstico precoce de injúria renal em uropatias obstrutivas congênitas". Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/5/5141/tde-28092018-101314/.

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Introdução: Os estudos com proteômica especificamente relacionada à nefrologia e urologia pediátrica são limitados. O diagnóstico do comprometimento da função renal e da sua deterioração na presença de uropatias obstrutivas congênitas (UOC) representa o desafio na rotina da nefro-urologia pediátrica. Novos biomarcadores com o potencial para detecção precoce da lesão renal surgiram recentemente, permitindo a escolha da melhor opção terapêutica no tempo hábil, e assim minimizando ou prevenindo o dano renal definitivo. Objetivos: Avaliar o perfil de dois biomarcadores renais séricos: creatinina (CrS) e cistatina C (CyCs); e seis biomaracadores renais urinários: lipocalina associada à gelatinase neutrofílica (NGAL), proteína ligadora de retinol (RBP), molécula de injúria renal 1 (KIM-1), cistatina C na urina (CyCu), fator transformador de crescimento-beta 1 (TGF-beta1) e microalbuminúria (uALB) durante o primeiro ano de vida em lactentes saudáveis; em relação à detecção precoce da lesão renal em lactentes com UOC; em relação à sua capacidade de prever a necessidade de intervenção cirúrgica em lactentes com UOC. Metodologia: 37 lactentes com UOC foram divididos em três subgrupos: 14/37 casos com hidroureteronefrose unilateral (HU), 13/37 com hidroureteronefrose bilateral (HB) e 10/37 com obstrução de vias urinárias baixas (OTUB); e comparados com 24 lactentes saudáveis. No grupo dos pacientes, as amostras de sangue e urina foram obtidas ao nascer e entre o 3º e 7º dia, 1º, 2º, 3º, 6º, 9º e 12º mês de vida. Grupo de controle seguia o mesmo cronograma, com exceção da coleta de sangue que ocorria ao nascer, entre o 3º e 7º dia, no 6º e 12º mês de vida. Todas as amostras foram armazenadas sob - 70 ºC, e analisadas posteriormente através de imunoensaio enzimático quantitativo (ELISA). Resultados: No grupo-controle, CrS, CyCs, CyCu e RBP refletiram a maturação glomerular e tubular. O ritmo de filtração glomerular pela CyCs atingiu os níveis estáveis no 6º mês de vida (93 ± 22 mL/min/1,73 m2). KIM-1 e TGF-beta1 mantiveram os níveis absolutos próximos ao limite de detecção pelo método. Os valores do NGAL no sexo feminino foram significativamente maiores (p=0,005) ao longo do 1º ano, quando comparados aos do sexo masculino. Em comparação aos controles, a coorte dos pacientes apresentou valores mais elevados para todos os biomarcadores urinários no 1º mês de vida (p <= 0,009), sendo que NGAL (p=0,005), TGF-betsa1 (p < 0,001) e ?ALB (p < 0,001) mostraram-se elevados desde o nascimento, em comparação aos controles. O RBP apresentou o melhor desempenho no subgrupo com HB e OTUB (AUC=0,844, sensibilidade >=83,3%, especificidade 94,3%), assim como o KIM-1 no HU (AUC=0,768, sensibilidade 70,7%, especificidade 82,7%). RBP em combinação com TGF-ß1 ou KIM- 1 e NGAL com CyCs e CyCu, atingiram os melhores resultados para detecção da lesão renal (AUC=0,934, sensibilidade 89,4%, especificidade 92,8%; AUC=0,896, sensibilidade 86,8%, especificidade 81,1%; AUC=0,867, sensibilidade 92,4%, especificidade 79,5%, respectivamente). Nos pacientes operados, os níveis elevados de RBP (p <= 0,043), NGAL (p <= 0,043), KIM-1 (p <= 0,03) e TGF-beta1 (p <= 0,034) baixaram significativamente após a cirurgia, no subgrupo com HU e OTUB. NGAL, isolado ou em combinação, com CyCs e CyCu demonstrou o melhor desempenho para determinar a necessidade cirúrgica (AUC=0,801, sensibilidade 63,6%, especificidade 96,7%; AUC=0,881, sensibilidade 87,7%, especificidade 82,2%, respectivamente). A analise do perfil dos biomarcadores indicou a necessidade da intervenção cirúrgica em 55,4% (7/13) dos casos não-operados e antecipou a decisão cirúrgica no mínimo 3 meses, em 58% (14/24) de todos os pacientes operados, baseada nas diretrizes atuais. Conclusão: A evolução dos valores normais dos biomarcadores no primeiro ano de vida, pode servir como a base para os próximos estudos de detecção precoce de afecções uro-nefrologicas. RBP, NGAL, KIM-1, TGF-beta1 e CyC, individualmente ou em combinação, demonstraram um forte potencial para identificar a lesão renal e servir como uma ferramenta de diagnóstico não-invasivo para diferenciar pacientes que necessitam de intervenção cirúrgica precoce daqueles que se beneficiariam de uma conduta conservadora
Introduction: The proteomics studies specifically related to pediatric nephrology and urology are limited. The diagnosis of renal function impairment and deterioration in congenital obstructive uropathies (COU) represents challenge in pediatric nephrourology routine. New renal biomarkers applied in this setting have potential for early renal injury detection, allowing reliable choice of optimal therapeutic options and thus preventing or minimizing definitive renal damage. Objectives: To analyze the first-year profiles of two serum renal biomarkers: Creatinine (CrS) and Cystatin C (CyCs); and six urinary renal biomarkers: Neutrophil Gelatinase-Associated Lipocalin (NGAL), Retinol- Binding Protein (RBP), Kidney Injury Molecule-1 (KIM-1), urine Cystatin C (CyCu), Transforming Growth Factor Beta 1 (TGF-beta1), and microalbuminuria (uALB) in a cohort of healthy infants; in relation to early detection of renal injury capability in a group of infants with COU; in relation to capability of predicting the need for surgery in a group of infants with COU. Methods: 37 infants with COU were divided in 3 subgroups: 14/37 cases with unilateral hydro(uretero)nephrosis (UH), 13/37 with bilateral hydro(uretero)nephrosis (BH) and 10/37 patients with lower urinary tract obstruction (LUTO), compared with 24 healthy infants matched by gestational age and birth weight. In the patient group, blood and urine samples were collected at birth, between 3rd-7th day, at 1st, 2nd, 3rd, 6th, 9th and 12th month of age. In the control group urine sampling followed the same routine with exception that blood sampling was obtained between 3rd-7th day, at 6th and 12th month of age. The samples were stored at -70 ºC, and thereafter analyzed by quantitative enzymatic immunoassay (ELISA). Results: In the group of healthy controls, the values of CrS, CyCs, CyCu and RBP reflected glomerular and tubular maturation. The glomerular filtration rate by CyCs reached steady-state levels at 6th month of life (93 ± 22 mL/min/1,73 m2). KIM-1 and TGF-beta1maintained very low absolute levels, near to the limit of detection by the method. NGAL levels in females were significantly higher (p=0,005) throughout the first year of life, when compared to male gender. In the cohort of patients, all the urinary biomarkers showed significantly higher values at the first month of life (p <= 0,009), while NGAL (p=0,005), TGF-beta1(p < 0,001) e uALB (p < 0,001) were high since birth, compared to control group. The best single biomarker performance was achieved by RBP in BH and LUTO subgroups (AUC=0,844, sensitivity >= 83,3%, specificity 94,3%), and by KIM-1 in UH subgroup (AUC=0,768, sensitivity 70,7%, specificity 82,7%). The best biomarker combination results for all subgroups were obtained by matching RBP with TGF-beta1 or KIM-1 and NGAL with CyC (AUC=0,934, sensitivity 89,4%, specificity 92,8%; AUC=0,896, sensitivity 86,8%, specificity 81,1%; AUC=0,867, sensitivity 92,4%, specificity 79,5%, respectively). In the operated group of patients, the levels of RBP (p <= 0,043), NGAL (p <= 0,043), KIM-1 (p <= 0,03) e TGF-beta1 (p <= 0,034) dropped significantly after surgery, in UH and LUTO subgroups. NGAL alone or in combination with CyCs and CyCu, demonstrated the best performance to determine the need for surgery (AUC=0,801, sensitivity 63,6%, specificity 96,7%; AUC=0,881, sensitivity 87,7%, specificity 82,2%, respectively). Biomarkers\' profile analysis indicated the need for surgical intervention in 55,4% (7/13) of non-operated cases and anticipated clinically based surgical decision for at least 3 months, in 58% (14/24) of all operated patients. Conclusions: The presented biomarkers\' normal values evolution during the first year of life can be of use as a base for future studies that will involve early detection of uronephrological disorders in infants. RBP, NGAL, KIM-1, TGF-beta1 and CyC, alone or in combination, demonstrated strong capability to identify renal injury and serve as a noninvasive diagnostic tool for differentiating between infants that require early surgical intervention from those who would benefit from conservative approach
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Cordeiro, Mauricio Dener. "Fatores prognósticos em pacientes submetidos à desobstrução ureteral secundária a tumores urológicos ou extraurológicos". Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/5/5153/tde-14082014-144337/.

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INTRODUÇÃO E OBJETIVOS: Há controvérsias em relação à indicação e ao momento ideal de realização de derivação urinária em pacientes com obstrução ureteral secundária a neoplasias malignas avançadas. O objetivo do presente estudo foi identificar fatores relacionados ao mau prognóstico de pacientes com nefropatia obstrutiva maligna e criar um modelo de estratificação de risco desses pacientes, a fim de fornecer evidências para uma melhor decisão terapêutica. MÉTODO: Realizou-se estudo prospectivo com pacientes portadores de insuficiência renal obstrutiva por neoplasias pélvicas, acompanhados por um tempo mínimo de seis meses, tratados entre janeiro de 2009 à novembro de 2011. De um total de 340 pacientes submetidos à procedimentos de descompressão ureteral por catéter ureteral (CUR) ou nefrostomia percutânea (NPC), 208 foram incluídos no estudo por serem maiores de 18 anos, apresentarem obstrução ureteral secundária à neoplasias malignas, confirmada por tomografia computadorizada (TC) ou ultrassom (USG) e por terem realizado derivação urinária por catéter ureteral ou nefrostomia percutânea em nossa Instituição. RESULTADOS: A sobrevida média global foi de 144 dias, com mortalidade ao final do estudo de 164 pacientes (78.8%), sendo 44 (21.2%) durante a internação hospitalar. Não houve diferença significativa na sobrevida global entre os dois tipos de derivação urinária realizada (p = 0.216). Após análise univariada, a presença de qualquer sintoma (p = 0.014), derrame pleural (p = 0.015), grau de hidronefrose 1 e 2 (p = 0.001), Índice de Charlson >= 6 (p = 0.003), linfonodos retroperitoneais metastáticos (p = 0.002), linfonodos pélvicos metastáticos (p = 0.024), número de sítios relacionados à disseminação da doença >= 4 (p < 0.001), niveis séricos iniciais de uréia >= 80mg/dl (p = 0.01), sódio <= 138 mEq/L (p = 0.018) e albumina < 3.0 mg/dl (p = 0.035), diálise peri-operatória (p = 0.05) e índice de ECOG PS (Eastern Cooperative Oncology Group Performance Status) >= 2 (p < 0.001), foram associados a menor sobrevida média. A análise multivariada de Cox revelou que apenas o número de sítios relacionados à disseminação maligna (quatro ou mais) e o índice de ECOG PS >= 2 foram significativamente associados à menor sobrevida. A fim de criar um modelo de estratificação de risco, os pacientes foram, posteriormente, divididos em três grupos: nenhum fator de risco - grupo I, um fator de risco - II e dois fatores de risco - III. As taxas de sobrevida mediana de 1,6 e 12 meses nesses grupos foram, respectivamente de 94.4%, 57.3% e 44.9% no grupo I, de 78.0%, 36.3% e 15.5% no grupo II e de 46.4%, 14.3% e 7.1% no grupo III, com diferenças significativas nos perfis de sobrevivência dos três grupos de risco (p < 0.001). CONCLUSÕES: Nosso modelo de estratificação de risco poderá representar uma ferramenta útil na decisão de se instituir procedimentos de desobstrução ureteral em pacientes com neoplasias abdominopélvicas malignas avançadas. Pacientes com mais de quatro sítios de metástases e com índice de performance (ECOG) igual ou superior a 2 apresentam pobre evolução após derivações urinárias realizadas para tratar nefropatia obstrutiva maligna. De acordo com o método de estratificação de risco de óbito por nós descrito, pacientes com um ou mais fatores de risco evoluem com sobrevida mais precária que os casos sem fatores de risco presentes
INTRODUCTION AND OBJECTIVES: There is a controversy regarding the decision to perform diversion procedures in patients with ureteral obstruction secondary to advanced malignancies. The goal of this study was to identify poor prognosis factors and to create a model to stratify patients with malignant obstructive nephropathy in order to provide evidence-based information for better treatment decisions. METHODS: A prospective study was performed from January 2009 to November 2011, with patients followed at least for 6 months. From 340 patients initially submitted to ureteral decompression procedures by ureteral stents or percutaneous nephrostomy, 208 were elected for the study because they were 18 years old or more and presented ureteric obstruction secondary to any type of malignancy, confirmed by computadorized tomography (CT) or ultrasound (US) and were submitted to urinary diversion by ureteral stents or percutaneous nephrostomy at our institution.RESULTS: The median survival for all patients was 144 days, with mortality at the end of study seen in 164 patients (78.8%) including 44 (21.2%) during hospitalization. There was no significant difference in overall survival between the two types of urinary diversion (p = 0.216). After univariated analysis the presence of any symptoms (p = 0.014), pleural effusion (p = 0.015), degree of hydronephrosis 1 and 2 (p = 0.001), Charlson Index >= 6 (p = 0.003), metastatic retroperitoneal lymph nodes (p = 0.002), metastatic pelvic lymph nodes (p = 0.024), number of sites related to dissemination >= 4 (p < 0.001), preoperative serum level urea >= 80mg/dl (p = 0.01), sodium <= 138mEq/L (p = 0.018), albumin < 3.0 mg/dl (p = 0.035), perioperative dyalisis (p = 0.05) and ECOG PS index >= 2 (p < 0.001) were associated to shorter mean survival. The multivariate Cox proportional hazards regression model revelead that only the number of sites related to malignant dissemination (4 or more) and the index of performance status of Eastern Cooperative Oncology Group (ECOG PS >= 2) were significantly associated with short survival. To creat a risk stratification model, the patients were further divided into three risk groups: no risk factor - favorable group, one risk factor - intermediate and two risk factors - unfavorable, to creat a risk stratification model. The median survival rates at 1,6 and 12 months were respectively, 94.4%, 57.3% and 44.9% in the favorable group; 78.0%, 36.3% and 15.5% in the intermediate group and 46.4%, 14.3% and 7.1% in the unfavorable group. There were significant differences in the survival profiles of the three risk groups (p < 0.001). CONCLUSION: Our model of stratification may be a useful tool before deciding on ureteral desobstruction procedures in patients with advanced abdominopelvic malignancies. Patients with more than four sites of metastases and performance index (ECOG) equal to or greater than 2 have a poorer outcome after urinary diversion. According to the method of risk stratification for death from we described, patients with one or more risk factors have significant poorer outcome than cases with no risk factors
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Książki na temat "Hydronephrosis"

1

García, Barbara Marie. The ultrasonographic differentiation of obstructive vs. nonobstructive hydronephrosis in children: A multivariate scoring system. [New Haven, Conn: s.n.], 1995.

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2

C, Anderson James. Hydronephrosis. Elsevier Science & Technology Books, 2017.

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3

Gosling, J. A., P. H. O'Reilly i E. C. Edwards. Idiopathic Hydronephrosis. Springer, 2011.

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4

Gosling, J. A., P. H. O'Reilly i E. C. Edwards. Idiopathic Hydronephrosis. Springer London, Limited, 2012.

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Karanfilovski, Vlatko. Renal Lymphangiectasia: An Unusual Mimicker of Hydronephrosis. BAYSHOP (Generis Publishing), 2022.

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Cure Hydronephrosis: The Complete Guide On Everything You Need To Know About Hydronephrosis Cure, Treatment, Prevention And Diet. Independently published, 2021.

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Onen, Abdurrahman, Ali Avanoglu, Luis Henrique Braga i Venkata R. Jayanthi, red. Hydronephrosis Associated with Ureteropelvic Junction Anomalies: An Ongoing Challenge. Frontiers Media SA, 2022. http://dx.doi.org/10.3389/978-2-88976-184-5.

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Publications, ICON Health. Hydronephrosis - A Medical Dictionary, Bibliography, and Annotated Research Guide to Internet References. ICON Health Publications, 2004.

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Wahlin, Nils. Hydronephrosis in Childhood: An Experimental and Clinical Study (Comprehensive Summaries of Uppsala Dissertations, 934). Uppsala Universitet, 2000.

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Fox, Grenville, Nicholas Hoque i Timothy Watts. Endocrinology. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780198703952.003.0016.

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This chapter provides background information on fetal and neonatal renal development, physiology, and function. Detailed information is given on management of common, antenatally diagnosed, renal anomalies (renal pelvis dilatation/hydronephrosis); post-natal diagnoses (hypospadius, hydrocele); posterior urethral valves; polycystic kidney disease; and rarer diagnoses. There is a guideline on the management of acute renal failure in the newborn, and information on dialysis.
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Części książek na temat "Hydronephrosis"

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Alexander, A., i H. von Bezing. "Hydronephrosis". W ABC of Pediatric Surgical Imaging, 66–67. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-540-89385-1_33.

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Villani, Maria Felicia, Milena Pizzoferro, Simona Nappo i Maria Carmen Garganese. "Hydronephrosis". W Conventional Nuclear Medicine in Pediatrics, 23–40. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-43181-9_4.

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Weill, Francis S., Edmond Bihr, Paul Rohmer i François Zeltner. "Hydronephrosis". W Renal Sonography, 39–57. Berlin, Heidelberg: Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-70417-8_3.

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Choudhury, Subhasis Roy. "Hydronephrosis". W Pediatric Surgery, 289–96. Singapore: Springer Singapore, 2018. http://dx.doi.org/10.1007/978-981-10-6304-6_47.

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Griffin, Ashlee M., i Praise Matemavi. "Hydronephrosis". W Complications in Kidney Transplantation, 119–23. Cham: Springer International Publishing, 2022. http://dx.doi.org/10.1007/978-3-031-13569-9_19.

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Darrad, Maitrey, Ameet Gupta i Nick Rukin. "Hydronephrosis". W Blandy's Urology, 165–88. Chichester, UK: John Wiley & Sons, Ltd, 2019. http://dx.doi.org/10.1002/9781118863343.ch10.

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Corcos, Jacques, i Mikolaj Przydacz. "Hydronephrosis". W Consultation in Neurourology, 213–28. Cham: Springer International Publishing, 2017. http://dx.doi.org/10.1007/978-3-319-63910-9_12.

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Silva, Andres, i Hiep T. Nguyen. "Fetal Hydronephrosis". W Pediatric Urology for the Primary Care Physician, 1–10. New York, NY: Springer New York, 2014. http://dx.doi.org/10.1007/978-1-60327-243-8_1.

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Dason, Shawn, i Luis H. P. Braga. "Prenatal hydronephrosis". W Evidence-Based Urology, 185–96. Chichester, UK: John Wiley & Sons, Ltd, 2018. http://dx.doi.org/10.1002/9781119129875.ch15.

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Ahmad, Ardalan E., i Barry A. Kogan. "Congenital Hydronephrosis". W Congenital Anomalies of the Kidney and Urinary Tract, 77–93. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-29219-9_5.

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Streszczenia konferencji na temat "Hydronephrosis"

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Alsheimer, K., J. W. Burgei, J. Lantry, H. Shah i B. Lamichhane. "Genitourinary Tuberculosis Resulting in Hydronephrosis". W American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a2354.

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Dlewati, M., W. Battle i M. K. Greer. "Respiratory Failure Secondary to Giant Hydronephrosis". W American Thoracic Society 2024 International Conference, May 17-22, 2024 - San Diego, CA. American Thoracic Society, 2024. http://dx.doi.org/10.1164/ajrccm-conference.2024.209.1_meetingabstracts.a4581.

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RODRIGUES, Isabelle Medeiros, João Francisco Bianchini de TOLEDO, Thiago Abreu SAMAN i Mário dos Santos FILHO. "UNILATERAL HYDRONEPHROSIS DUE TO URETER OBSTRUCTION AFTER OVARIO-HYSTERECTOMY IN A FELINE - CASE REPORT". W SOUTHERN BRAZILIAN JOURNAL OF CHEMISTRY 2021 INTERNATIONAL VIRTUAL CONFERENCE. DR. D. SCIENTIFIC CONSULTING, 2022. http://dx.doi.org/10.48141/sbjchem.21scon.34_abstract_rodrigues.pdf.

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Hydronephrosis is characterized by the renal pelvis and calyces distension resulting from total or partial urinary outflow obstruction. Ureter injuries are recognized complications of abdominal surgeries, especially sterilization, due to the frequency which they are performed in cats and dogs and the proximity between the ureter and the uterine stump. Some injuries may be acute or chronic, uni or bilaterally, affecting the urinary tract segment parts. Therefore, diagnosis is very important, especially early on, since it makes immediate management easier and may result in a better prognosis, especially when the disease course gets interrupted or its progression gets slowed. Furthermore, the importance of performing sporadic exams, even without previous clinical history for feline patients, is notorious since the nature of the species to hide clinical signs is well known. To certify the success of the surgery and integrity of the organs, it is very important to perform post sterilization exams. It is also crucial to state the importance of computed tomography for the diagnosis since some obstruction causes, such as blood clot, may not be shown in the ultrasound. Computed tomography is also necessary to differentiate hydronephrosis from many injuries that may affect the kidneys and ureters, like ectopic ureter, obstruction by calculi, and surgical ligature. The present study has the objective of reporting and discussing the laboratory, imaging findings, and clinical state of a patient with unilateral hydronephrosis, with asymptomatic evolution of iatrogenic origin due to obstruction by ureter obliteration after ovariohysterectomy (OVH).
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Cerrolaza, Juan J., Enrico Grisan, Nabile Safdar, Emmarie Myers, James Jago, Craig A. Peters i Marius George Linguraru. "Quantification of kidneys from 3D ultrasound in pediatric hydronephrosis". W 2015 37th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC). IEEE, 2015. http://dx.doi.org/10.1109/embc.2015.7318324.

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Wertaschnigg, D., C. Wohlmuth, C. Schimke i TA Kiener. "Ultrasound markers in fetal hydronephrosis to predict postnatal surgery". W Ultraschall 2017. Georg Thieme Verlag KG, 2017. http://dx.doi.org/10.1055/s-0037-1606902.

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Razanadahy, T., N. Andrianandrasana, M. Razakanaivo, HM Rakotomalala i F. Rafaramino. "193 Hydronephrosis in cervical cancer patients in Antananarivo, Madagascar". W IGCS 2020 Annual Meeting Abstracts. BMJ Publishing Group Ltd, 2020. http://dx.doi.org/10.1136/ijgc-2020-igcs.167.

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Cerrolaza, Juan J., Craig A. Peters, Aaron D. Martin, Emmarie Myers, Nabile Safdar i Marius G. Linguraru. "Ultrasound based computer-aided-diagnosis of kidneys for pediatric hydronephrosis". W SPIE Medical Imaging, redaktorzy Stephen Aylward i Lubomir M. Hadjiiski. SPIE, 2014. http://dx.doi.org/10.1117/12.2043072.

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Cerrolaza, Juan J., Hansel Otero, Peter Yao, Elijah Biggs, Awais Mansoor, Roberto Ardon, James Jago, Craig A. Peters i Marius George Linguraru. "Semi-automatic assessment of pediatric hydronephrosis severity in 3D ultrasound". W SPIE Medical Imaging, redaktorzy Georgia D. Tourassi i Samuel G. Armato. SPIE, 2016. http://dx.doi.org/10.1117/12.2216830.

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Abdullah, N., T. Ameen, R. Albdulwasa'a, GC Alkholidy i M. Shoaib. "An abdonminal cerebrospinal fluid pseudocyst with hydronephrosis post ventriculoperitoneal shunt". W MSF Paediatric Days 2022. NYC: MSF-USA, 2022. http://dx.doi.org/10.57740/ayzy-ej78.

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Dhindsa, Kiret, Lauren C. Smail, Melissa McGrath, Luis H. Braga, Suzanna Becker i Ranil R. Sonnadara. "Grading Prenatal Hydronephrosis from Ultrasound Imaging Using Deep Convolutional Neural Networks". W 2018 15th Conference on Computer and Robot Vision (CRV). IEEE, 2018. http://dx.doi.org/10.1109/crv.2018.00021.

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Raporty organizacyjne na temat "Hydronephrosis"

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Britto, Maneka, Noor Buchholz i Krishanu Das. How to manage hydronephrosis in pregnancy. BJUI Knowledge, marzec 2022. http://dx.doi.org/10.18591/bjuik.0400.v2.

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Kern, Nora, i Anthony Herndon. Antenatal hydronephrosis (2): further imaging, diagnosis and management. BJUI Knowledge, marzec 2022. http://dx.doi.org/10.18591/bjuik.0671.v2.

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Kern, Nora, i Anthony Herndon. Antenatal hydronephrosis (1): postnatal evaluation and initial management. BJUI Knowledge, marzec 2022. http://dx.doi.org/10.18591/bjuik.0278.v2.

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How to manage hydronephrosis in pregnancy. BJUI Knowledge, wrzesień 2018. http://dx.doi.org/10.18591/bjuik.0400.

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Antenatal hydronephrosis - postnatal evaluation and initial management. BJUI Knowledge, styczeń 2017. http://dx.doi.org/10.18591/bjuik.0278.

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Antenatal hydronephrosis - further imaging, diagnosis and management. BJUI Knowledge, styczeń 2017. http://dx.doi.org/10.18591/bjuik.0671.

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