Zaloguj się

Gotowe bibliografie tematyczne / Human-relevant / Artykuły w czasopismach

Artykuły w czasopismach na temat „Human-relevant”

Kliknij ten link, aby zobaczyć inne rodzaje publikacji na ten temat: Human-relevant.

Autor: Grafiati

Data publikacji: 26 lipca 2024

Data aktualizacji: 27 lipca 2024

Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych

Wybierz rodzaj źródła:

Sprawdź 50 najlepszych artykułów w czasopismach naukowych na temat „Human-relevant”.

Przycisk „Dodaj do bibliografii” jest dostępny obok każdej pracy w bibliografii. Użyj go – a my automatycznie utworzymy odniesienie bibliograficzne do wybranej pracy w stylu cytowania, którego potrzebujesz: APA, MLA, Harvard, Chicago, Vancouver itp.

Możesz również pobrać pełny tekst publikacji naukowej w formacie „.pdf” i przeczytać adnotację do pracy online, jeśli odpowiednie parametry są dostępne w metadanych.

Przeglądaj artykuły w czasopismach z różnych dziedzin i twórz odpowiednie bibliografie.

1

Nasimi Chingizzadeh, Chingiz. "HUMAN RIGHTS RELEVANT TO TRADEMARKS". ANCIENT LAND 03, nr 04 (30.06.2021): 19–21. http://dx.doi.org/10.36719/2706-6185/03/19-21.

Pełny tekst źródła

Streszczenie:

Human rights and trademark laws do not go well together. This is partly the result of an educational tradition and the division of legal research into private and commercial law on the one hand and public law, international law and human rights law on the other. This division is also reinforced by the historical judiciary in many countries. However, human rights concerns are becoming more and more relevant in trademark law. Keywords: Intellectual property, trademark, human rights, freedom of expression, privacy, property

Style APA, Harvard, Vancouver, ISO itp.

2

Boring, Ronald L., Emilie Roth, Oliver Straeter, Karin Laumann, Harold S. Blackman, Johanna Oxstrand i Julius J. Persensky. "Is Human Reliability Relevant to Human Factors?" Proceedings of the Human Factors and Ergonomics Society Annual Meeting 53, nr 10 (październik 2009): 610–14. http://dx.doi.org/10.1177/154193120905301006.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

3

Bresciani, Katia Denise S., André Luiz B. Galvão, Amanda L. de Vasconcellos, José Antonio Soares, Lucas Vinicius Shigaki de Matos, Julia Cestari Pierucci, Luiz da Silveira Neto i in. "Relevant aspects of human toxoplasmosis". Research Journal of Infectious Diseases 1, nr 1 (2013): 7. http://dx.doi.org/10.7243/2052-5958-1-7.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

4

Chingizzadeh, Chingiz. "HUMAN RIGHTS RELEVANT TO TRADEMARKS". ANCIENT LAND 3, nr 4 (19.04.2021): 21–24. http://dx.doi.org/10.36719/2706-6185/06/21-24.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

5

Dhobale, Manisha Randhir, Nitin Radhakishan Mudiraj i Medha Girish Puranik. "CLINICALLY RELEVANT MORPHOMETRIC STUDY OF LEFT CORONARY ARTERY IN ADULT HUMAN CADAVERS". International Journal of Anatomy and Research 6, nr 3.3 (5.09.2018): 5605–12. http://dx.doi.org/10.16965/ijar.2018.290.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

6

Speers, Marjorie A. "Human Research Accreditation Relevant to Anthropology". Anthropology News 45, nr 6 (wrzesień 2004): 27. http://dx.doi.org/10.1111/an.2004.45.6.27.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

7

Avanzini, G. "Animal models relevant to human epilepsies". Italian Journal of Neurological Sciences 16, nr 1-2 (marzec 1995): 5–8. http://dx.doi.org/10.1007/bf02229068.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

8

Rizzo, Carmen, Giuseppa Genovese, Marina Morabito, Caterina Faggio, Maria Pagano, Antonio Spanò, Vincenzo Zammuto i in. "Potential Antibacterial Activity of Marine Macroalgae against Pathogens Relevant for Aquaculture and Human Health". Journal of Pure and Applied Microbiology 11, nr 4 (30.12.2017): 1695–706. http://dx.doi.org/10.22207/jpam.11.4.07.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

9

Carpenter, Richard, i Hui-Wen Lo. "STAT3 Target Genes Relevant to Human Cancers". Cancers 6, nr 2 (16.04.2014): 897–925. http://dx.doi.org/10.3390/cancers6020897.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

10

Hall, Judith G. "How imprinting is relevant to human disease". Development 108, Supplement (1.04.1990): 141–48. http://dx.doi.org/10.1242/dev.108.supplement.141.

Pełny tekst źródła

Streszczenie:

Genomic imprinting appears to be a ubiquitous process in mammals involving many chromosome segments whose affects are dependent on their parental origin. One of the challenges for clinical geneticists is to determine which disorders are manifesting imprinting effects and which families are affected. Re-evaluation of cases of chromosomal abnormalities and family histories of disease manifestations should give important clues. Examination of the regions of human chromosomes homologous to mouse imprinted chromosomal regions may yield useful information. Cases of discordance in monozygous twins may also provide important insights into imprinted modification of diseases.

Style APA, Harvard, Vancouver, ISO itp.

11

Martin, Paul J. "Animal experimentation relevant to human marrow transplantation". Current Opinion in Oncology 4, nr 2 (kwiecień 1992): 239–46. http://dx.doi.org/10.1097/00001622-199204000-00002.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

12

Gao, Xiao, Jie Ling, Xiaohui Xiao i Miao Li. "Learning Force-Relevant Skills from Human Demonstration". Complexity 2019 (3.02.2019): 1–11. http://dx.doi.org/10.1155/2019/5262859.

Pełny tekst źródła

Streszczenie:

Many human manipulation skills are force relevant, such as opening a bottle cap and assembling furniture. However, it is still a difficult task to endow a robot with these skills, which largely is due to the complexity of the representation and planning of these skills. This paper presents a learning-based approach of transferring force-relevant skills from human demonstration to a robot. First, the force-relevant skill is encapsulated as a statistical model where the key parameters are learned from the demonstrated data (motion, force). Second, based on the learned skill model, a task planner is devised which specifies the motion and/or the force profile for a given manipulation task. Finally, the learned skill model is further integrated with an adaptive controller that offers task-consistent force adaptation during online executions. The effectiveness of the proposed approach is validated with two experiments, i.e., an object polishing task and a peg-in-hole assembly.

Style APA, Harvard, Vancouver, ISO itp.

13

Wardle, E. N. "Endothelial cell antibodies: relevant in human disease?" Nephrology Dialysis Transplantation 10, nr 4 (kwiecień 1995): 577–78. http://dx.doi.org/10.1093/ndt/10.4.577b.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

14

Spencer, Sean P., Gabriela K. Fragiadakis i Justin L. Sonnenburg. "Pursuing Human-Relevant Gut Microbiota-Immune Interactions". Immunity 51, nr 2 (sierpień 2019): 225–39. http://dx.doi.org/10.1016/j.immuni.2019.08.002.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

15

Savalli, Carine, Maria M. Brandão, Thais S. Domingues, Maria A. Honório i César Ades. "Dog-Human communication through a keyboard: Is human attentional state relevant?" Journal of Veterinary Behavior 4, nr 2 (marzec 2009): 55. http://dx.doi.org/10.1016/j.jveb.2008.09.054.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

16

Grohsjean, Thorsten, i David Kryscynski. "Origins of strategically relevant firm-specific human capital". Academy of Management Proceedings 2018, nr 1 (sierpień 2018): 11692. http://dx.doi.org/10.5465/ambpp.2018.11692abstract.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

17

Nikas, G. "Cell-surface morphological events relevant to human implantation". Human Reproduction 14, suppl 2 (1.12.1999): 37–44. http://dx.doi.org/10.1093/humrep/14.suppl_2.37.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

18

Ram, Rebecca. "Launch of the Alliance for Human Relevant Science". Alternatives to Laboratory Animals 45, nr 1 (marzec 2017): 49–53. http://dx.doi.org/10.1177/026119291704500109.

Pełny tekst źródła

Streszczenie:

The Alliance is an exciting new collaboration, founded to address an urgent need to drive research and development, policymaking, awareness, outreach, and education into human-based methods of safety testing and biomedical research

Style APA, Harvard, Vancouver, ISO itp.

19

SANZ, INAKI, LARN-YUAN HWANG, CHARLES HASEMANN, JAMES THOMAS, RICHARD WASSERMAN, PHILIP TUCKER i J. DONALD CAPRA. "Polymorphisms of Immunologically Relevant Loci in Human Disease." Annals of the New York Academy of Sciences 546, nr 1 Molecular Bas (grudzień 1988): 133–42. http://dx.doi.org/10.1111/j.1749-6632.1988.tb21628.x.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

20

Battino, Maurizio, Jules Beekwilder, Beatrice Denoyes-Rothan, Margit Laimer, Gordon J. McDougall i Bruno Mezzetti. "Bioactive compounds in berries relevant to human health". Nutrition Reviews 67 (maj 2009): S145—S150. http://dx.doi.org/10.1111/j.1753-4887.2009.00178.x.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

21

Emery Thompson, Melissa, Alexandra G. Rosati i Noah Snyder-Mackler. "Insights from evolutionarily relevant models for human ageing". Philosophical Transactions of the Royal Society B: Biological Sciences 375, nr 1811 (21.09.2020): 20190605. http://dx.doi.org/10.1098/rstb.2019.0605.

Pełny tekst źródła

Streszczenie:

As the world confronts the health challenges of an ageing population, there has been dramatically increased interest in the science of ageing. This research has overwhelmingly focused on age-related disease, particularly in industrialized human populations and short-lived laboratory animal models. However, it has become clear that humans and long-lived primates age differently than many typical model organisms, and that many of the diseases causing death and disability in the developed world are greatly exacerbated by modern lifestyles. As such, research on how the human ageing process evolved is vital to understanding the origins of prolonged human lifespan and factors increasing vulnerability to degenerative disease. In this issue, we highlight emerging comparative research on primates, highlighting the physical, physiological, behavioural and cognitive processes of ageing. This work comprises data and theory on non-human primates, as well as under-represented data on humans living in small-scale societies, which help elucidate how environment shapes senescence. Component papers address (i) the critical processes that comprise senescence in long-lived primates; (ii) the social, ecological or individual characteristics that predict variation in the pace of ageing; and (iii) the complicated relationship between ageing trajectories and disease outcomes. Collectively, this work provides essential comparative, evolutionary data on ageing and demonstrates its unique potential to inform our understanding of the human ageing process. This article is part of the theme issue ‘Evolution of the primate ageing process’.

Style APA, Harvard, Vancouver, ISO itp.

22

Blendy, Julie A. "Modeling Neuropsychiatric Disease-Relevant Human SNPs in Mice". Neuropsychopharmacology 36, nr 1 (30.11.2010): 364–65. http://dx.doi.org/10.1038/npp.2010.143.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

23

Borgert, Christopher J., John C. Matthews i Stephen P. Baker. "Human-relevant potency threshold (HRPT) for ERα agonism". Archives of Toxicology 92, nr 5 (9.04.2018): 1685–702. http://dx.doi.org/10.1007/s00204-018-2186-z.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

24

Lavery, W. Lindsay. "How relevant are animal models to human ageing?" Journal of the Royal Society of Medicine 93, nr 6 (czerwiec 2000): 296–98. http://dx.doi.org/10.1177/014107680009300605.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

25

Jacobs, Gordon B., Tetsuzo Agishi, Robert Ecker, Thomas Meaney, Raymond J. Kiraly i Yukihiko Nosé. "Human Thoracic Anatomy Relevant to Implantable Artificial Hearts". Artificial Organs 2, nr 1 (12.11.2008): 64–82. http://dx.doi.org/10.1111/j.1525-1594.1978.tb01005.x.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

26

Mooney, S. D., i R. B. Altman. "MutDB: annotating human variation with functionally relevant data". Bioinformatics 19, nr 14 (22.09.2003): 1858–60. http://dx.doi.org/10.1093/bioinformatics/btg241.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

27

Mills, Melody, i Mary K. Estes. "Physiologically relevant human tissue models for infectious diseases". Drug Discovery Today 21, nr 9 (wrzesień 2016): 1540–52. http://dx.doi.org/10.1016/j.drudis.2016.06.020.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

28

Wrobel, Sonja. "222b - Relevant information and challenges for human biomonitoring". Annals of Work Exposures and Health 68, Supplement_1 (1.06.2024): 1. http://dx.doi.org/10.1093/annweh/wxae035.159.

Pełny tekst źródła

Streszczenie:

Abstract Human biomonitoring (HBM) has proven to be a useful tool to perform risk assessment of chemicals. Nevertheless, certain criteria for a reliable HBM should be taken into account. Knowledge regarding the suitability of the chosen biological matrix, as well as the specificity and sensitivity of biomarkers is essential. For a specific HBM, the biomarker must not be formed from other substances with expected exposures. The sensitivity of the biomarker depends on the aim of the study with higher sensitivities needed for the investigation of background exposures in the general population, compared to verifying the adherence to health-based guidance values (e.g., in an occupational context). Furthermore, aspects of analytical ruggedness of the biomarkers need to be considered, such as susceptibility to pre-analytical contamination. To obtain valid HBM results, analytical methods for these biomarkers need to be sufficiently sensitive, selective, and rugged and need to be applied under quality-assured conditions. In this presentation, the choice of a reliable biomarker will be discussed using practical examples.

Style APA, Harvard, Vancouver, ISO itp.

29

Doyle, Brian. "Book Review: Human Rights and Disabled Persons: Essays and Relevant Human Rights Instruments". International Journal of Discrimination and the Law 1, nr 3 (marzec 1996): 295–99. http://dx.doi.org/10.1177/135822919600100308.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

30

Hoogensen, GunhildBazely,. "Human Security in the Arctic - Yes, It Is Relevant!" Journal of Human Security 5, nr 2 (2009): 1–10. http://dx.doi.org/10.3316/jhs0502001.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

31

Jung, Hee-Won. "Frailty as a Clinically Relevant Measure of Human Aging". Annals of Geriatric Medicine and Research 25, nr 3 (30.09.2021): 139–40. http://dx.doi.org/10.4235/agmr.21.0106.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

32

Somepalli, Gowthami, Sarthak Sahoo, Arashdeep Singh i Sridhar Hannenhalli. "Prioritizing and characterizing functionally relevant genes across human tissues". PLOS Computational Biology 17, nr 7 (16.07.2021): e1009194. http://dx.doi.org/10.1371/journal.pcbi.1009194.

Pełny tekst źródła

Streszczenie:

Knowledge of genes that are critical to a tissue’s function remains difficult to ascertain and presents a major bottleneck toward a mechanistic understanding of genotype-phenotype links. Here, we present the first machine learning model–FUGUE–combining transcriptional and network features, to predict tissue-relevant genes across 30 human tissues. FUGUE achieves an average cross-validation auROC of 0.86 and auPRC of 0.50 (expected 0.09). In independent datasets, FUGUE accurately distinguishes tissue or cell type-specific genes, significantly outperforming the conventional metric based on tissue-specific expression alone. Comparison of tissue-relevant transcription factors across tissue recapitulate their developmental relationships. Interestingly, the tissue-relevant genes cluster on the genome within topologically associated domains and furthermore, are highly enriched for differentially expressed genes in the corresponding cancer type. We provide the prioritized gene lists in 30 human tissues and an open-source software to prioritize genes in a novel context given multi-sample transcriptomic data.

Style APA, Harvard, Vancouver, ISO itp.

33

Ryu, Hyun-Wook, Dong Hoon Lee, Hye-Rim Won, Kyeong Hwan Kim, Yun Jeong Seong i So Hee Kwon. "Influence of Toxicologically Relevant Metals on Human Epigenetic Regulation". Toxicological Research 31, nr 1 (31.03.2015): 1–9. http://dx.doi.org/10.5487/tr.2015.31.1.001.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

34

Pacione, Michael. "The relevance of religion for a relevant human geography". Scottish Geographical Journal 115, nr 2 (styczeń 1999): 117–31. http://dx.doi.org/10.1080/14702549908553821.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

35

Kryscynski, David, i Dave Ulrich. "Making Strategic Human Capital Relevant: A Time-Sensitive Opportunity". Academy of Management Perspectives 29, nr 3 (sierpień 2015): 357–69. http://dx.doi.org/10.5465/amp.2014.0127.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

36

Chin, Benjamin M., i Johannes Burge. "Human sensitivity to task-relevant features in speed discrimination". Journal of Vision 19, nr 10 (6.09.2019): 168b. http://dx.doi.org/10.1167/19.10.168b.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

37

Tully, C. J. "Information, Human Activity and the Nature of Relevant Theories". Computer Journal 28, nr 3 (1.03.1985): 206–10. http://dx.doi.org/10.1093/comjnl/28.3.206.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

38

Ferrone, Soldano, i Giuseppe Sconocchia. "A clinically relevant mouse model of human multiple myeloma?" Blood 106, nr 2 (15.07.2005): 388–89. http://dx.doi.org/10.1182/blood-2005-04-1676.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

39

Zivin, J. A., i J. C. Grotta. "Animal stroke models. They are relevant to human disease." Stroke 21, nr 7 (lipiec 1990): 981–83. http://dx.doi.org/10.1161/01.str.21.7.981.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

40

Fussell, Karma C., Steffen Schneider, Stephanie Melching-Kollmuss, Sibylle Groeters, Volker Strauss, Benazir Siddeek, Mohamed Benahmed, Markus Frericks i Bennard van Ravenzwaay. "Testing mixtures in vivo at human-relevant exposure levels". Toxicology Letters 221 (sierpień 2013): S25. http://dx.doi.org/10.1016/j.toxlet.2013.06.088.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

41

Hanington, Bruce M. "Relevant and Rigorous: Human-Centered Research and Design Education". Design Issues 26, nr 3 (lipiec 2010): 18–26. http://dx.doi.org/10.1162/desi_a_00026.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

42

van Thriel, Christoph. "Aluminium affects neurospheres at human in vivo relevant concentrations". Archives of Toxicology 94, nr 10 (25.08.2020): 3601–2. http://dx.doi.org/10.1007/s00204-020-02889-x.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

43

Snyder, Jason S., i Heather A. Cameron. "Could adult hippocampal neurogenesis be relevant for human behavior?" Behavioural Brain Research 227, nr 2 (luty 2012): 384–90. http://dx.doi.org/10.1016/j.bbr.2011.06.024.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

44

Yadav, Pramod Kumar, Victor Vitvitsky, Sebastián Carballal, Javier Seravalli i Ruma Banerjee. "Thioredoxin regulates human mercaptopyruvate sulfurtransferase at physiologically-relevant concentrations". Journal of Biological Chemistry 295, nr 19 (16.03.2020): 6299–311. http://dx.doi.org/10.1074/jbc.ra120.012616.

Pełny tekst źródła

Streszczenie:

3-Mercaptopyruvate sulfur transferase (MPST) catalyzes the desulfuration of 3-mercaptopyruvate (3-MP) and transfers sulfane sulfur from an enzyme-bound persulfide intermediate to thiophilic acceptors such as thioredoxin and cysteine. Hydrogen sulfide (H2S), a signaling molecule implicated in many physiological processes, can be released from the persulfide product of the MPST reaction. Two splice variants of MPST, differing by 20 amino acids at the N terminus, give rise to the cytosolic MPST1 and mitochondrial MPST2 isoforms. Here, we characterized the poorly-studied MPST1 variant and demonstrated that substitutions in its Ser–His–Asp triad, proposed to serve a general acid–base role, minimally affect catalytic activity. We estimated the 3-MP concentration in murine liver, kidney, and brain tissues, finding that it ranges from 0.4 μmol·kg−1 in brain to 1.4 μmol·kg−1 in kidney. We also show that N-acetylcysteine, a widely-used antioxidant, is a poor substrate for MPST and is unlikely to function as a thiophilic acceptor. Thioredoxin exhibits substrate inhibition, increasing the KM for 3-MP ∼15-fold compared with other sulfur acceptors. Kinetic simulations at physiologically-relevant substrate concentrations predicted that the proportion of sulfur transfer to thioredoxin increases ∼3.5-fold as its concentration decreases from 10 to 1 μm, whereas the total MPST reaction rate increases ∼7-fold. The simulations also predicted that cysteine is a quantitatively-significant sulfane sulfur acceptor, revealing MPST's potential to generate low-molecular-weight persulfides. We conclude that the MPST1 and MPST2 isoforms are kinetically indistinguishable and that thioredoxin modulates the MPST-catalyzed reaction in a physiologically-relevant concentration range.

Style APA, Harvard, Vancouver, ISO itp.

45

Su, Mack Y., Laurie A. Steiner, Hannah Bogardus, Tejaswini Mishra, Vincent P. Schulz, Ross C. Hardison i Patrick G. Gallagher. "Identification of Biologically Relevant Enhancers in Human Erythroid Cells". Journal of Biological Chemistry 288, nr 12 (22.01.2013): 8433–44. http://dx.doi.org/10.1074/jbc.m112.413260.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

46

Su, Mack, Laurie A. Steiner, Hannah Bogardus, Vincent P. Schulz, Ross C. Hardison i Patrick G. Gallagher. "Identification of Biologicaly Relevant Enhancers in Human Erythroid Cells". Blood 120, nr 21 (16.11.2012): 368. http://dx.doi.org/10.1182/blood.v120.21.368.368.

Pełny tekst źródła

Streszczenie:

Abstract Abstract 368 Identification of cell-type specific enhancers is important for understanding the regulation of programs controlling cellular development and differentiation. Recent studies utilizing genomic methodologies have shown that enhancers are frequently associated with biologically relevant and disease-associated genetic variants. Enhancers are typically marked by the co-transcriptional activator protein p300 or by groups of cell-expressed transcription factors. We hypothesized that a unique set of enhancers regulate gene expression in human erythroid cells, a highly specialized cell type evolved to provide adequate amounts of oxygen throughout the body. Using chromatin immunoprecipitation followed by massively parallel sequencing, genome-wide maps of candidate enhancers were constructed for p300 and four transcription factors, GATA1, NF-E2, KLF1, and SCL, in primary human erythroid cells. These data were combined with parallel gene expression analyses and candidate enhancers identified. Cell and tissue-type specific enhancers act over distances of tens to hundreds of kilobases, thus bona fide erythroid enhancers are expected to be enriched in the genomic vicinity of genes expressed and functional in erythroid cells. Sites of occupancy were correlated with levels of gene expression. Promoter sites within 2kb of annotated transcriptional start sites (TSS) were excluded. Consistent with their predicted function, there was significant enrichment of p300 peaks within 2–50kb of the TSS of genes highly expressed in erythroid cells c.f. peaks >100kb of a TSS. There was also significant enrichment of combinations of 2, 3, and 4 co-localizing erythroid transcription factor peaks within 2–50kb of the TSS of genes highly expressed in erythroid cells. In contrast, similar to other cell type-specific enhancers, there was no enrichment of p300 or erythroid transcription factor sites within 2–50kb of genes highly expressed in nonerythroid cells. When analyses were performed comparing a set of erythroid-specific genes vs. a random set of genes, there was significant enrichment of combinations of 2, 3, and 4 co-localizing erythroid transcription factor binding sites, but not p300, within 2–50kb of the TSS of erythroid-specific genes. Evolutionary analyses revealed high conservation between man and chimp for p300 and erythroid transcription factors. However, there was a very large falloff between human and mouse, with. Disclosures: No relevant conflicts of interest to declare.

Style APA, Harvard, Vancouver, ISO itp.

47

Steinberg, Daniel, i Joseph L. Witztum. "Is the Oxidative Modification Hypothesis Relevant to Human Atherosclerosis?" Circulation 105, nr 17 (30.04.2002): 2107–11. http://dx.doi.org/10.1161/01.cir.0000014762.06201.06.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

48

Opelz, Gerhard, i Frans H. J. Claas. "Which human leukocyte antigen antibodies are really clinically relevant?" Human Immunology 70, nr 8 (sierpień 2009): 561–62. http://dx.doi.org/10.1016/j.humimm.2009.06.019.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

49

Atanasova, Srebrena, Markus Hirschburger, Danny Jonigk, Martin Obert, Kathrin Petri, Alena Evers, Andreas Hecker i in. "A relevant experimental model for human bronchiolitis obliterans syndrome". Journal of Heart and Lung Transplantation 32, nr 11 (listopad 2013): 1131–39. http://dx.doi.org/10.1016/j.healun.2013.07.016.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

50

Khabieva, Zaira Dokuevna, Leyla Alievna Gadzhialieva i Magomedrasul Magomediminovich Alibekov. "IMPROVING HUMAN RESOURCE MANAGEMENT BASED ON RELEVANT HR REFORMS". Industrial Economics 7, nr 5 (2022): 659–63. http://dx.doi.org/10.47576/2712-7559_2022_5_7_659.

Pełny tekst źródła

Style APA, Harvard, Vancouver, ISO itp.

Oferujemy zniżki na wszystkie plany premium dla autorów, których prace zostały uwzględnione w tematycznych zestawieniach literatury. Skontaktuj się z nami, aby uzyskać unikalny kod promocyjny!