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Harley-McClaskey, Deborah. "Leadership Impact on Human Resources". Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etsu-works/4714.
Pełny tekst źródłaGomes, Mariana Lourenço Mocho Fernandes. "Lifestyle impact on human sperm function". Master's thesis, Universidade de Aveiro, 2015. http://hdl.handle.net/10773/14848.
Pełny tekst źródłaOxidative stress (OS) is believed to be an important cause of male infertility, which accounts for about half of all infertility cases. Reactive species (RS)- induced OS is detrimental to spermatozoa, leading to the damage of many biomolecules, such as lipids, proteins and DNA. Several lifestyle factors, such as alcohol and tobacco consumption, are known to induce OS and have been studied for their negative effects on male reproductive system. The aim of this study was to evaluate the impact of acute lifestyle changes, namely alcohol and tobacco consumption, on semen quality, accessory glands function and oxidative balance of sperm cells. Furthermore, the correlation between the OS parameters analyzed and the basic semen parameters was also assessed. Male students, in reproductive age, who participated in the academic festivities, donated a semen sample at three time points: before and one week and three months after the academic festivities. Basic semen analysis was performed and, subsequently, semen samples were processed. Acessory glands function was evaluated and OS was analyzed through measurement of the total antioxidant capacity of the sperm cells and through determination of the expression of antioxidant enzymes glutathione peroxidase 4 and superoxide dismutase 1. The impact of ROS in spermatozoa was also assessed through the determination of the protein carbonyl and 3-nitrotyrosine groups. The results indicate that a decrease in semen quality, demonstrated by a decrease in progressive motility and neutral α-glucosidase concentration and an increase in tail defects, occurs due to lifestyle alterations. The total antioxidant status of sperm cells and variations in protein oxidation levels are dependent on the alcohol and tobacco consumption. Moreover, some correlations were observed between the studied parameters, which may be useful in a clinical perspective. In conclusion, the lifestyle alterations are responsible for a decrease in semen quality and by an increase in protein modifications, which may consequently lead to a decrease in fertilizing potential.
O stress oxidativo (OS) tem sido considerado uma causa importante da infertilidade masculina, que está envolvida em cerca de metade dos casos de infertilidade. O OS induzido pelas espécies reativas (RS) é prejudicial para os espermatozoides, levando a lesões em várias biomoléculas, como os lípidos, proteínas e DNA. Alterações no estilo de vida, como o consumo excessivo de álcool e tabaco, induzem o OS e têm sido extensivamente estudadas devido aos seus efeitos negativos ao nível do sistema reprodutor masculino. O objetivo deste estudo foi analisar o impacto de alterações agudas no estilo de vida, nomeadamente o consumo de álcool e tabaco, na qualidade seminal, na função das glândulas acessórias e no equilibrio oxidativo dos espermatozoides. Para além disso, outro objetivo deste trabalho foi avaliar a possível relação entre os parâmetros de OS e os parâmetros seminais analisados. Estudantes masculinos, em idade fértil, que participaram nas festividades académicas, doaram uma amostra de sémen em três períodos de tempo: antes e uma semana e três meses após as festividades académicas. A análise básica ao sémen foi realizada e, posteriormente, as amostras foram processadas. A função das glândulas acessórias foi avaliada, assim como determinada a capacidade antioxidante total das células, a expressão das enzimas antioxidantes superóxido dismutase 1 e glutationa peroxidase 4 e a presença de grupos carbonilo e 3-nitrotirosina. Os resultados indicam que uma diminuição na qualidade seminal, demostrada por um decréscimo na motilidade progressiva dos espermatozoides e na concentração de α-glucosidase neutra e um aumento nos defeitos da cauda, ocorre devido a alterações no estilo de vida. A capacidade antioxidante total das células e as variações ao nível da oxidação proteica demonstram também ser dependentes do consumo de alcool e tabaco. Foram também verificadas algumas correlações entre os parâmetros analisados que poderão ser importantes numa perspetiva clínica. Concluindo, alterações no estilo de vida são responsáveis pela diminuição da qualidade seminal e pelo aumento de modificações proteicas, o que pode levar consequentemente a um decréscimo do potencial de fertilização.
Cruz, Daniel Filipe Soares Pereira da. "Lifestyle impact on human sperm oxidative balance". Master's thesis, Universidade de Aveiro, 2014. http://hdl.handle.net/10773/13262.
Pełny tekst źródłaInfertility is a clinical condition that affects about 15% of reproductive-aged couples worldwide. Half of these cases are due to male factors. A large percentage of male infertility cases are idiopathic, however, in the last years the influence of oxidative stress in decreased semen quality has been discussed. The lifestyle, including consumption of alcohol, tobacco, drugs and the alteration in circadian cycle, has been proposed as responsible for the increase of reactive oxygen species (ROS). This increase leads to an alteration of the balance between oxidants and antioxidant defenses present in the organism, causing oxidative stress. High levels of ROS damage biomolecules – DNA, proteins or lipids – present in sperm cells and may lead to the loss of membrane integrity, DNA fragmentation or even to death by apoptosis. The aims of the thesis was to evaluate the influence of acute lifestyle changes on oxidative balance of sperm cells. Therefore, we analyzed the antioxidant capacity of the sperm, as well as the presence of certain antioxidant proteins, by colorimetric techniques and immunoblotting. We also evaluated the effect of ROS by measuring the protein oxidation. The seminal quality was evaluated by performing a routine semen analysis. The results indicate that there is a relationship between the changes in lifestyle and the amount of antioxidants in sperm, and the most reported change involved the protein superoxide dismutase (SOD). It was also demonstrated that the variation in protein oxidation levels is dependent on the consumption of alcohol and nicotine. In this study it was concluded that oxidative balance of sperm cells is affected by lifestyle changes; in turn, oxidative balance changes is then reflected in semen quality.
A infertilidade é um problema clínico que afeta cerca de 15% dos casais em idade fértil. Metade dos casos de infertilidade deve-se a fatores masculinos, sendo que uma grande percentagem tem origem idiopática. Nos últimos anos tem-se discutido a influência do stress oxidativo na diminuição da qualidade seminal. O estilo de vida, nomeadamente o consumo de álcool e tabaco têm sido fatores propostos como responsáveis pelo aumento de espécies reativas de oxigénio (ROS), levando a uma alteração do equilíbrio entre os oxidantes e as defesas antioxidantes presentes no organismo, causando stress oxidativo. Níveis aumentados de ROS danificam as biomoléculas – DNA, proteínas ou lípidos – presentes nos espermatozoides, podendo levar à perda da integridade da membrana, à fragmentação de DNA ou até mesmo à morte por apoptose. Este estudo tem como objetivo avaliar a influência da alteração aguda do estilo de vida no equilíbrio oxidativo dos espermatozoides. Desta forma, foi analisada a capacidade antioxidante dos espermatozoides, bem como a presença de certas proteínas antioxidantes, através de técnicas colorimétricas e de immunoblotting. Foi também avaliado o efeito das ROS através da medição de oxidação proteica. A qualidade seminal foi avaliada através da realização de espermogramas. Os resultados obtidos indicam que existe uma relação entre as alterações do estilo de vida e a quantidade de antioxidantes no espermatozoide, sendo que a alteração mais marcada envolveu a proteína superóxido dismutase (SOD). Foi também detetado uma variação dos níveis de oxidação proteica, dependente da alteração dos consumos de álcool e nicotina. Com este trabalho concluiu-se que o equilíbrio oxidativo dos espermatozoides é afetado pelas alterações no estilo de vida, sendo que a alteração deste equilíbrio reflete-se posteriormente na qualidade seminal.
Richards, Joseph B. "Impact of the Internet on consumer human capital". Related electronic resource: Current Research at SU : database of SU dissertations, recent titles available full text, 2002. http://wwwlib.umi.com/cr/syr/main.
Pełny tekst źródłaChu, Suk-ling, i 朱淑玲. "Impact of indoor air pathogens on human health". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1996. http://hub.hku.hk/bib/B31253362.
Pełny tekst źródłaDede, Eric O. "The impact of land contamination on human health". Thesis, University of Reading, 2018. http://centaur.reading.ac.uk/76618/.
Pełny tekst źródłaMartins, Amadeu Manuel Quelhas. "The impact of cardiac feedback on human cognition". Thesis, University of Birmingham, 2011. http://etheses.bham.ac.uk//id/eprint/1308/.
Pełny tekst źródłaBunting, M. J. "Environmental history and human impact in Orkney, Scotland". Thesis, University of Cambridge, 1993. https://www.repository.cam.ac.uk/handle/1810/271916.
Pełny tekst źródłaKhoruzhii, V. V., Марина Миколаївна Дунаєва, Марина Николаевна Дунаева i Maryna Mykolaivna Dunaieva. "The impact of chronic stress on human health". Thesis, Sumy State University, 2020. https://essuir.sumdu.edu.ua/handle/123456789/77970.
Pełny tekst źródłaMelnik, Y., i T. Linnik. "Chemtrails impact on the environment and human brains". Thesis, Сумський державний університет, 2013. http://essuir.sumdu.edu.ua/handle/123456789/30866.
Pełny tekst źródłaRentzsch, Viola. "Human trafficking 2.0 the impact of new technologies". University of the Western Cape, 2021. http://hdl.handle.net/11394/8353.
Pełny tekst źródłaHuman history is traversed by migration. This manifold global phenomenon has shaped the world to its current state, moving people from one place to another in reaction to the changing world. The autonomous decision to permanently move locations represents only a segment of what is considered to be migration. Routes can be dangerous, reasons can be without any alternative, displacements forced, and journeys deadly. Arguably the most fatal of all long-distance global migration flows, the transatlantic slave trade has left an enduring legacy of economic patterns and persistent pain. Whilst the trade in human beings originated centuries before, with Europe’s long history of slavery, this event represents an atrocious milestone in history. In a nutshell, European colonialists traded slaves for goods from African kings, who had captured them as war prisoners.
Chu, Suk-ling. "Impact of indoor air pathogens on human health /". Hong Kong : University of Hong Kong, 1996. http://sunzi.lib.hku.hk/hkuto/record.jsp?B17457798.
Pełny tekst źródłaAtomsa, Nebiyu Tariku <1993>. "The Impact of Climate Change on Human Health". Master's Degree Thesis, Università Ca' Foscari Venezia, 2022. http://hdl.handle.net/10579/21902.
Pełny tekst źródłaOliva, Pavia Meritxell. "Functional impact of polymorphic inversions in the human genome". Doctoral thesis, Universitat Autònoma de Barcelona, 2014. http://hdl.handle.net/10803/286269.
Pełny tekst źródłaAn inversion is a balanced genomic rearrangement that alters the orientation of a specific genomic sequence. Despite not usually causing gain or loss of DNA, inversions can alter the original genetic background and produce mutational and positional effects on genes. In addition, inversions can alter recombination patterns both on the DNA sequences encompassed by them and in their vicinity. Therefore, inversions may associate with certain phenotypes or diseases, shape the evolutionary fate of the carriers by adaptive processes or even play a role in the origin of new species. For all that, increasing our knowledge of inversions constitutes a key issue for in-depth understanding of genome variation and its consequences. However, little is known about the prevalence and functional impact of inversions in the human genome, and in particular of their association with gene expression changes in humans. For the last 10 years, the advent of novel genomic technologies has enabled the study of SVs, including inversions, in a high-throughput fashion within and across species. State of the art genomic research provides the means and tools to explore the human genome in detail and expand our knowledge of inversions. Against this backdrop, the INVFEST project has devoted efforts to build the most accurate and exhaustive catalogue of human polymorphic inversions to date. For that, we have benchmarked GRIAL, currently the only paired-end mapping (PEM) based algorithm specifically designed to predict inversions, and demonstrated that performs with more accuracy and efficiency compared to other PEM based SV-detection methods, particularly in refining inversion BPs. In addition, we have curated GRIAL inversion predictions by using several pre and post PEM mapping filters coupled with manual inspection of complex cases and minimized the rate of false positive predictions. Next, to gain further insight on the functional impact of polymorphic inversions in the human genome, we examined the overlap of 44 different inversions with genes. Overall, our results show that inversions tend to be located in intergenic regions but in 13.6% of the cases gene exons are affected. We performed two complementary approaches to identify inversion associations with gene expression. First, we performed a linear regression analysis in three different expression datasets derived from 527 lymphoblastoid cell lines (LCLs) of European, Asian and African HapMap individuals. Second, we interrogated blood and non-blood tissues by contrasting expression quantitative trait loci (eQTL) data with inversion tag-SNPs. We report 19 inversion rearrangements that modulate gene expression of 43 genes in several tissues. These results seem consistent as a subset (N = 11) of the associations found in LCLs has been identified by both approaches. Interestingly, we have identified an inversion that affects the expression of paralogous protein-coding genes (IFITM2/IFITM3) in lymphocyte-derived cells. We have also validated the methodology used for differential expression analysis by reproducing known effects of two well-studied inversions (17q21.31, 8p23.1) and identified novel associations of both inversion haplotypes with the expression of 6 genes. Moreover, we observe that at least 2 of these genes are associated to 17q21.31 structural rearrangements. Finally, we have looked for possible associations of inversions with disease and found one inversion that seems to be associated with amyotrophic lateral sclerosis in two different GWAS studies. Insight gained in this study could therefore contribute to a better understanding of the role of polymorphic inversions in the regulation of gene expression and the consequences of this understudied type of genetic variants in humans.
Hughes, Timothy A. "Biomechanical model of the human thorax for impact analysis". Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1999. http://handle.dtic.mil/100.2/ADA370880.
Pełny tekst źródła"September 1999". Thesis advisor(s): Young W. Kwon. Includes bibliographical references (p. 49-50). Also available online.
HASSAN, ABDULLAHI NUR, i JAMES RAD ANAMAN. "THE IMPACT OF HUMAN RESOURCES MANAGEMENT ON CUSTOMER SATISFACTION". Thesis, Mälardalen University, School of Business, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-6404.
Pełny tekst źródłaGrant, Michael James. "The palaeoecology of human impact in the New Forest". Thesis, University of Southampton, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.427406.
Pełny tekst źródłaDodd, R. H. "Examining the psychosocial impact of human papillomavirus oropharyngeal cancer". Thesis, University College London (University of London), 2016. http://discovery.ucl.ac.uk/1522414/.
Pełny tekst źródłaBankole, Felix Olubisi. "Investigating the impact of ICT investments on human development". Master's thesis, University of Cape Town, 2009. http://hdl.handle.net/11427/11873.
Pełny tekst źródłaIncludes bibliographical rereneces (leaves 114-128).
In the last two decades, the worldwide information and communication technology (ICT) market has been growing at a rapid rate. This has led to the global net increase in ICT usage and investments. International organizations, ICT vendors, policy makers have been trying to determine if such huge investments are worthwhile. However, the result regarding this issue is inconclusive, for this research area is fraught with complexity and existing empirical study is limited. Investigating the impact of ICT investments on human development requires appropriate methods that can provide a deeper understanding and which are based on IS perspective theory. Of particular importance are different aspects of ICT investments and the components of human development. For example, ICT investments consist of four aspects namely hardware, software, internal spending and telecommunication investments while human development components are GOP, literacy rates and life expectancy rates. If these variables are not modelled correctly, their effect on each other can be either under- or overestimated and the appropriate level of impact is therefore required.
Zhang, Feng. "Cyanobacterial blooms: causes, innovative monitoring and human health impact". The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1405800137.
Pełny tekst źródłaGodwin, Donna D. "The Impact of Gender on Domestic Human Rights Abuse". Thesis, University of North Texas, 2004. https://digital.library.unt.edu/ark:/67531/metadc4515/.
Pełny tekst źródłaKanda, Tomo. "The Impact of Environmental Factors on Human Physiological Functions". Kyoto University, 2000. http://hdl.handle.net/2433/181025.
Pełny tekst źródła0048
新制・課程博士
博士(人間・環境学)
甲第8460号
人博第90号
11||158(吉田南総合図書館)
新制||人||22(附属図書館)
UT51-2000-F364
京都大学大学院人間・環境学研究科文化・地域環境学専攻
(主査)教授 家森 幸男, 教授 津田 謹輔, 助教授 森谷 敏夫
学位規則第4条第1項該当
Shorthouse, Edward. "Climate change and buildings : the impact on human health". Thesis, University of Exeter, 2015. http://hdl.handle.net/10871/21077.
Pełny tekst źródłaAida, Toru. "Study of human head impact brain tissue constitutive models /". Morgantown, W. Va. : [West Virginia University Libraries], 2000. http://etd.wvu.edu/templates/showETD.cfm?recnum=1402.
Pełny tekst źródłaTitle from document title page. Document formatted into pages; contains x, 133 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 122-130).
Jackson, Anita Estell. "The Impact of Human Resources on Nurses' Turnover Intention". ScholarWorks, 2020. https://scholarworks.waldenu.edu/dissertations/7932.
Pełny tekst źródłaGrudina, Clara. "The impact of FOXG1 on human cortico-cerebral astrogenesis". Doctoral thesis, SISSA, 2015. http://hdl.handle.net/20.500.11767/4856.
Pełny tekst źródłaVerma, Khyati. "Characterization of human heart and lung under dynamic impact". Thesis, IIT Delhi, 2018. http://eprint.iitd.ac.in:80//handle/2074/8035.
Pełny tekst źródłaPanzer, Matthew. "Numerical Modelling of the Human Cervical Spine in Frontal Impact". Thesis, University of Waterloo, 2006. http://hdl.handle.net/10012/2865.
Pełny tekst źródłaA biofidelic model of the human cervical spine was developed with a focus on accurate representation of the cervical spine at the local tissue level. These tissues were assembled to create a single segment model that was representative of in vitro spine in quasi-static loading. Finally, the single segment models were assembled to create a full cervical spine model that was simulated in dynamic loading and compared to human volunteer response.
Models of each segment were constructed from the basic building blocks of the cervical spine: the intervertebral disc, the vertebrae, the ligaments, and the facet joints. Each model was simulated in all modes of loading and at different levels of load. The results of the study indicate that the cervical spine segments performed very well in flexion, compression, and tension. Segment response to lateral bending and axial rotation was also good, while response in extension often proved too compliant compared to the experimental data. Furthermore, the single segment models did not fully agree with the experimental shear response, again being more compliant.
The full cervical spine model was assembled from the single segment models incorporating neck musculature. The model was simulated dynamically using a 15 G frontal impact test. Active muscles were used to simulate the response of the human volunteers used in the study. The response of the model was in reasonable agreement with the experimental data, and compared better than current finite element cervical spine models. Higher frequency oscillation caused most of the disagreement between the model and the experimental data, which was attributed to a lack of appropriate dynamic material properties of the soft tissues of the spine. In addition, a study into the active properties of muscle indicated that muscle response has a significant influence on the response of the head.
A number of recommendations were proposed that would improve the biofidelity of the model. Furthermore, it was recommended that the future goal of this model would be to implement injury-predicting capabilities through the development of advance material models.
Afshan, Sheeva. "Search-based generation of human readable test data and its impact on human oracle costs". Thesis, University of Sheffield, 2013. http://etheses.whiterose.ac.uk/4337/.
Pełny tekst źródłaSingh, Neelam. "A Study of Human Impact on Sacred Groves in India". Ohio University / OhioLINK, 2006. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1153856401.
Pełny tekst źródłaRobinette, Paul. "Developing robots that impact human-robot trust in emergency evacuations". Diss., Georgia Institute of Technology, 2015. http://hdl.handle.net/1853/54415.
Pełny tekst źródłaKim, Hyeon Jin. "The impact of learning on low-skilled workers' skill-improvement". Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1243956905.
Pełny tekst źródłaAlabdullatif, Abdulrahman M. "Impact of Lighting on Human Biomechanical Response During Lifting in Confined Spaces". University of Cincinnati / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1479809352830833.
Pełny tekst źródłaEscarré, Urueña Roberto. "The higher education role in building human capital. Impact evaluation of higher education capacity building interventions in developing countries". Doctoral thesis, Universidad de Alicante, 2015. http://hdl.handle.net/10045/54051.
Pełny tekst źródłaJolly, Johannes E. "Impact analysis of a biomechanical model of the human thorax". Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 2000. http://handle.dtic.mil/100.2/ADA379713.
Pełny tekst źródłaThesis advisor(s): Kwon, Young W. ; Baker, Steven R. "June 2000." Includes bibliographical references (p. 89-90). Also available online.
El-Sayed, Moustafa Julia Sarah. "Genomic structural variation and its impact on the human phenotype". Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/39129.
Pełny tekst źródłaSieswerda, Lee Edward. "Towards measuring the impact of ecological desintegrity on human health". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape9/PQDD_0025/MQ40111.pdf.
Pełny tekst źródłaBenz, Susanne [Verfasser], i Patrick [Akademischer Betreuer] Blum. "Human Impact on Groundwater Temperatures / Susanne Benz ; Betreuer: P. Blum". Karlsruhe : KIT-Bibliothek, 2016. http://d-nb.info/1124903003/34.
Pełny tekst źródłaThalmann, Vanessa. "Prison labour for private corporations : the impact of human rights". Thesis, McGill University, 2004. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=82672.
Pełny tekst źródłaThe question of private sector involvement in prison facilities raises significant concerns as regards to international labour standards. Opponents of private sector involvement argue that private hiring of prison labour can involve exploitation. They also argue that the authority for punishment is a core governmental function that cannot be delegated to the private sector. Furthermore, in most cases, labour and social security laws are not applied to inmates. Therefore, prison labour can constitute unfair competition with free labour or even go as far as to replace free labour.
Andric, Maja. "Transition to farming and human impact on the Slovenian landscape". Thesis, University of Oxford, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365514.
Pełny tekst źródłaLomax, Tim Matthew. "Holocene vegetation history and human impact in Western Lewis, Scotland". Thesis, University of Birmingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529393.
Pełny tekst źródłaCouey, James S., i Randal Alan Dragon. "The impact of human factors on decision making in combat". Thesis, Monterey, California: Naval Postgraduate School, 1990. http://hdl.handle.net/10945/27733.
Pełny tekst źródłaThis thesis identifies those human factors which impact on a commander's decision in a tactical combat environment. Various models for categorization are discussed. The study argues that in order to establish clear causaleffect relationships between human factors and battle outcome, concentration of analytical research must focus on first order effects. Two categorical judgment surveys in the form of questionnaires are developed. Results from the surveys are transformed to interval scales. The first survey is exploratory in nature and allows respondents to apply 27 endogenous factors within a generic tactical context. The second survey presents four specific tactical scenarios in which the top seven factors identified in the first survey can be applied. Respondent selection for the first survey represented the four military services while respondent selection for the second survey was limited to Army officers. The study concludes that the top seven factors are: Leadership, TrainingExperience, Initiative, Discipline, Cohesion, Morale, and WillMotivation. The rank order and scaled magnitudes of these factors are found to be scenario dependent.
Coombes, Paul Melor Vernon. "The palaeoecology of recent human impact in the Lake District". Thesis, University of Southampton, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.396760.
Pełny tekst źródłaSinilkina, А., i L. Royenko. "The unpredictable impact of human behavior on the economic processes". Thesis, КНУТД, 2016. https://er.knutd.edu.ua/handle/123456789/5027.
Pełny tekst źródłaShvachko, D. "Hardness of water and its impact on the human body". Thesis, Sumy State University, 2017. http://essuir.sumdu.edu.ua/handle/123456789/62813.
Pełny tekst źródłaVan, Herwerden L. "Human recreational activity and its impact on a metropolitan coastline". Master's thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/14356.
Pełny tekst źródłaRecreation has an important social function in modern societies, with ever-increasing pressures in the day-to-day life being felt by most people. This study addresses the impact of recreational activity on metropolitan shorelines, with particular reference to the False Bay shoreline. During summer holiday periods shoreline utilization in the Western Cape peaks on the public holidays of 26 December, 1 and 2 January, beach attendances reaching levels of 2 to 10 times higher than attendances on other days during the summer holidays. The greatest proportion of visitors to the beach (94%) engage in non-exploitative activities, such as sunbathing and swimming. Most visitors occur on the beaches between 12h00 and 16h00, week-ends being most popular during out-of-season periods, but in-season week day attendances exceed those of weekends. Only 6% of visitors surveyed were engaged in exploitative activities such as angling and bait- or food-gathering. Conservation awareness of visitors to the shore is related to the place of residence of the person, as well as activity engaged in by the person. Fish numbers and their size frequency distributions in protected areas differs to those of unprotected areas. If boulders on a sheltered shore are over-turned during bait gathering it has an adverse effect on the boulder communities, whether the boulders are replaced or left over-turned. When bait gatherers target on mussel-worms as bait, they may cause inadvertent damage to the primary matrix of mussel bed or tube-worm reef in the process, thereby affecting ecological succession processes in the intertidal environment. Management of metropolitan shorelines must therefore provide for quality recreational experiences, while applying conservation measures to selected areas that are susceptible to over-exploitation under the onslaught of ever-increasing numbers of recreationists. For such measures to be of any benefit to the marine environment, it is essential that people are not only informed, but that the regulations are also properly enforced.
Benz, Susanne Amelie [Verfasser], i Patrick [Akademischer Betreuer] Blum. "Human Impact on Groundwater Temperatures / Susanne Benz ; Betreuer: P. Blum". Karlsruhe : KIT-Bibliothek, 2016. http://d-nb.info/1124903003/34.
Pełny tekst źródłaCunha, Virgínia Filipa Pereira Monteiro da. "Human adipose tissue primary cultures and impact in prostate cancer". Master's thesis, Universidade de Aveiro, 2009. http://hdl.handle.net/10773/8985.
Pełny tekst źródłaProstate cancer (Pca) is one of the most frequent diagnosed neoplasies and the second cause of cancer-related death in the world, in men. Between others risk factors, obesity has been associated to Pca although the innerent mechanisms to this association remain to be clear. With this work, throuhg in vitro studies, we wish to contribute to the understanding of the impact of white adipose tissue and its sub-fractions (adipocytes and stromal vascular fraction), from visceral and periprostatic anatomic regions, in celular proliferation, apoptosis and invasion of castration sensitivity (LNCaP) and castration resistant (PC-3) prostate cells. With the purpose of obtaining answers directly from humam studies, were performed visceral and periprostatic adipose tissue primary cultures obtained during urologic surgeries (radical prostatectomy and prostatic adenomectomy) (n=16). Adipose tissue was used to make primary organotipical cultures (WAT) and after collagenase digestion adipocytes and SVF primary cultures. Sobrenatants and infranatants of each culture were collect and used as conditioned medium representing adipokines production. LNCaP and PC-3 cell lines were stimulated with these mediums and apoptosis, proliferation and invasion were evaluated, in vitro. This study model represent a potential form for analyze the impact of adipose tissue in tumor cells, allowing to evaluate adipose tissue-tumor interactions. The results show that adipose tissue promotes tumor cells proliferation, that periprostatic adipose tissue increase apoptosis in obese individuals and that SVF subfraction suppresses invasion of PC-3 cells through a direct effect in tumor cells.
O Cancro da próstata (CaP) é uma das neoplasias mais frequentemente diagnosticadas e a segunda causa de morte por cancro no mundo nos homens. Entre outros factores de risco, a obesidade tem sido frequentemente associada a CaP, embora permaneçam por esclarecer os mecanismos subjacentes a esta associação. Com o presente trabalho pretendeu-se através de estudos in vitro, contribuir para a compreensão do impacto do tecido adiposo branco e suas sub-fracções (adipócitos e fracção vascular estromal), com origens anatómicas periprostática e viceral, na proliferação, apoptose, e invasão celular de células de cancro da próstata sensíveis à castração (LNCaP) e resistentes à castração (PC-3). Com o propósito de obter respostas directamente através de estudos em humanos, foram efectuadas culturas primárias de tecido adiposo periprostático e visceral obtido durante cirurgias urológicas (prostatectomia radical e adenomectomia prostática) (n=16). O tecido adiposo foi utilizado para realizar culturas primárias organotípicas (tecido adiposo total fraccionado) e após digestão com colagenase culturas primárias de adipócitos e de células da fracção vascular estromal do tecido adiposo. Foram colhidos sobrenadantes e infranadantes destas culturas de tecido adiposo e utilizados como meios condicionados representativos da produção de adipocinas. As linhas celulares LNCaP e PC-3 foram estimuladas com estes meios e avaliados a apoptose, proliferação celular e invasividade tumoral in vitro. Este modelo de estudo representa um potencial meio para análise do impacto do tecido adiposo nas células tumorais, permitindo avaliar as interacções tecido adiposo-tumor. Os resultados evidenciam que o tecido adiposo promove a proliferação das células tumorais, que o tecido adiposo periprostático aumenta a apoptose em indivíduos obesos e que os SVF suprimem a invasão das PC-3 através de um efeito directo nas células tumorais.
Juarez, Jessica K. "Validation study of blunt force impact to the human cranium". Cincinnati, Ohio : University of Cincinnati, 2009. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1242834279.
Pełny tekst źródłaAdvisor: Alan P. Sullivan, III. Title from electronic thesis title page (viewed Aug. 11, 2009). Includes abstract. Keywords: blunt force; cranium. Includes bibliographical references.
Couey, James S. Dragon Randal Alan. "The impact of human factors on decision making in combat /". Monterey, California : Naval Postgraduate School, 1990. http://handle.dtic.mil/100.2/ADA232760.
Pełny tekst źródłaThesis Advisor(s): Parry, Samuel H. Second Reader: Hoffman, James C. "June 1990." Description based on signature page as viewed on October 21, 2009. DTIC Identifier(s): Human factors engineering, decision making, combat forces, surveys, theses, environmental factors, MANPRINT, combat modeling, command and control, mathematical analysis. Author(s) subject terms: Combat modeling, combat performance, command and control, decision-making, environmental factors, human factors, MANPRINT. Includes bibliographical references (p. 209-213). Also available online.