Rozprawy doktorskie na temat „Human cell types”
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Yeudall, W. Andrew. "Human papillomavirus types in oral squamous cell carcinogenesis". Thesis, University of Glasgow, 1991. http://theses.gla.ac.uk/40921/.
Pełny tekst źródłaBjörklund, Frida. "Subcellular mapping of cell types in healthy human pancreatic islets". Thesis, KTH, Proteinvetenskap, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-302215.
Pełny tekst źródłaLangerhanska öar består av endokrina celler som utsöndrar hormoner nödvändiga för reglering av blodsockernivåerna. Tidigare forskning har visat att genuttrycket och funktionaliteten är heterogen i de celler som utgör mänskliga Langerhanska öar. Dock är förståelsen för hur heterogeniteten korrelerar till normal cellfunktion och dysfunktion i diabetespatogenes fortfarande ofullständig. Följaktligen har ett internationellt samarbete inletts i syfte att undersöka vad som utgör heterogenitet i Langerhanska öar ur ett transkriptionellt, proteomiskt och funktionellt perspektiv i såväl friska som sjuka individer. I denna studie utvecklades en metod för multiplex mikroskopisk avbildning av vävnad för att möjliggöra undersökningen av hur proteiner som tidigare korrelerats med endokrin cellspecifik aktivitet och heterogenitet i Langerhanska öar var lokaliserade med hjälp av plattformen för Co-Detection by indEXing (CODEX). Totalt undersöktes 22 proteiner samtidigt varav 10 var specifikt uttryckta i celler som utgör Langerhanska öar. Bland dessa proteiner fanns generella markörer för vanligt förekommande celltyper i Langerhanska öar såsom C-peptid (C-pep) som markör för insulinsekreterande β-celler, glukagon (GCG) och somatostatin (SST) såväl som proteiner med färre kända funktioner såsom Shisa like B (FAM159B) och Neural proliferation, differentiation and control 1 (NPDC1). Med hjälp av multiplex mikroskopisk avbildning av vävnad kunde uttrycket av proteiner specifikt uttryckta i celler som utgör Langerhanska öar analyseras för enskilda celler i vävnaden. Denna analys visade att de flesta proteiner specifikt uttryckta i celler som Langerhanska öar består av var heterogent uttrycka. Resultaten från denna studie validerar att mikromiljön i Langerhanska öar är mycket komplex på grund av cellernas heterogenitet. Vidare visade denna studie att multiplex mikroskopisk avbildning av vävnad har potentialen att identifiera nya celltyper och interaktioner.
Butterworth, B. H. "Immunocytochemical characterization of the cell populations of the human placenta". Thesis, University of Cambridge, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.372864.
Pełny tekst źródłaReid, Fiona Jane. "Plasminogen activators and their inhibitor synthesized by human mesangial cells and other cell types". Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU539471.
Pełny tekst źródłaSchnyder-Candrian, Silvia. "Gene expression of neutrophil-activating peptides in various human cell types /". [S.l.] : [s.n.], 1994. http://www.ub.unibe.ch/content/bibliotheken_sammlungen/sondersammlungen/dissen_bestellformular/index_ger.html.
Pełny tekst źródłaGibson, Douglas Alistair. "Role for oestrogen in dynamic interactions between cell types within the human endometrium". Thesis, University of Edinburgh, 2012. http://hdl.handle.net/1842/9890.
Pełny tekst źródłaWATANABE, KAZUYOSHI, MITSUO MAEHARA i MASAO KITO. "THREE TYPES OF VOLTAGE-DEPENDENT CALCIUM CURRENTS IN CULTURED HUMAN NEUROBLASTOMA CELLS". Nagoya University School of Medicine, 1995. http://hdl.handle.net/2237/16080.
Pełny tekst źródłaIto, Akiko. "Histamine modulates three types of K^+ current in a human intestinal epithelial cell line". Kyoto University, 1997. http://hdl.handle.net/2433/202235.
Pełny tekst źródłaDimas, Antigone. "The role of regulatory variation in sculpting gene expression across human populations and cell types". Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608695.
Pełny tekst źródłaJohnson, Travis Steele. "Estimation of Neural Cell types in the Allen Human Brain Atlas using Murine-derived Expression Profiles". The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1461243036.
Pełny tekst źródłaPeters, Andrew. "Clinical, molecular, and phylogenetic characterisations of human T-cell lymphotropic virus types I and II in Canada". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0020/MQ58073.pdf.
Pełny tekst źródłaOrdway, Gregory A., Attila Szebeni, Michelle M. Duffourc i Katalin Szebeni. "Laser Capture Microdissection and RT- PCR Analyses of Specific Cell Types in Locus Coeruleus From Postmortem Human Brain". Digital Commons @ East Tennessee State University, 2007. https://dc.etsu.edu/etsu-works/8624.
Pełny tekst źródłaKelsey, William Patrick V. "Proteomic Analysis of the Nuclear Membranes of Human Periodontal Ligament Fibroblast and Gingival Fibroblast Cell Types: A Comparison Study". Columbus, Ohio : Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1243618431.
Pełny tekst źródłaRose, Stephanie Leigh. "Human immunodeficiency virus type 1 (HIV-1) gag-pro genetic variability is related to therapy response and impacts viral fitness in specific cell types". [Gainesville, Fla.] : University of Florida, 2002. http://purl.fcla.edu/fcla/etd/UFE1001177.
Pełny tekst źródłaBoytard, Ludovic. "Analyse moléculaire des types cellulaires impliqués dans l'anévrysme de l'aorte abdominale". Phd thesis, Université du Droit et de la Santé - Lille II, 2012. http://tel.archives-ouvertes.fr/tel-00825204.
Pełny tekst źródłaBailer, Robert T. "Human T-lymphotrophic virus types I/II in autoimmune diseases, growth characteristics and cytokine expression in AIDS-related Kaposi's sarcoma derived cell strains and patients, and constitutive cytokine expression in HTLV and STLV.. /". The Ohio State University, 1994. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487856076415404.
Pełny tekst źródłaBain, Peter A., i n/a. "Gene Expression Profiling of Cylindrospermopsin Toxicity". Griffith University. School of Biomolecular and Physical Sciences, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20080404.145834.
Pełny tekst źródłaBain, Peter A. "Gene Expression Profiling of Cylindrospermopsin Toxicity". Thesis, Griffith University, 2007. http://hdl.handle.net/10072/367068.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Physical Sciences
Faculty of Science, Environment, Engineering and Technology
Full Text
Furuta, Rie. "Human T-cell leukemia virus type 1 infects multiple lineage hematopoietic cells in vivo". Kyoto University, 2018. http://hdl.handle.net/2433/232110.
Pełny tekst źródłaBayraktutan, Ulvi. "Studies on human urokinase-type plasminogen activator receptor". Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.262679.
Pełny tekst źródłaMulgrew, Christopher James. "T-type calcium channels and human mesangial cell proliferation". Thesis, King's College London (University of London), 2012. https://kclpure.kcl.ac.uk/portal/en/theses/ttype-calcium-channels-and-human-mesangial-cell-proliferation(8d963ed0-7b21-4f73-bc94-ec5a76205bdd).html.
Pełny tekst źródłaSasada, Amane. "APOBEC3G targets human T-cell leukemia virus type 1". Kyoto University, 2006. http://hdl.handle.net/2433/143870.
Pełny tekst źródłaPise-Masison, Cynthia Ann. "Human Immunodeficiency Virus Type-1 Infection of Human Myeloid Cells". eScholarship@UMMS, 1994. https://escholarship.umassmed.edu/gsbs_diss/87.
Pełny tekst źródłaMoad, Mohammad. "Influence of cell type of origin to the differentiation potential of induced pluripotent stem cells derived from human urinary tract cells". Thesis, University of Newcastle upon Tyne, 2015. http://hdl.handle.net/10443/2803.
Pełny tekst źródłaHelt, Anna-Marija. "Multiple biological activities of the human papillomavirus type 16 E7 oncoprotein contribute to the abrogation of human epithelial cell cycle control /". Thesis, Connect to this title online; UW restricted, 2002. http://hdl.handle.net/1773/11514.
Pełny tekst źródłaDavis, Adam James. "Transcriptional analysis of human immunodeficiency virus type 1 infection following cell-to-cell transmission /". Title page, contents and abstract only, 1997. http://web4.library.adelaide.edu.au/theses/09PH/09phd2609.pdf.
Pełny tekst źródłaParish, Joanna L. "The induction of apoptosis by the human papillomavirus type 16 E2 protein". Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391157.
Pełny tekst źródłaLeeuwen, Ester Marga Maria van. "Induction and maintenance of human virus-specific T cells". [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2005. http://dare.uva.nl/document/78986.
Pełny tekst źródłaJong, Annemieke de. "T cell immunity against early antigens of human papillomavirus type 16 /". Leiden : Nautilus, 2005. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=014895978&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.
Pełny tekst źródłaChang, Miao. "Cell type specific regulation of human placenta growth factor gene transcription /". Available to subscribers only, 2008. http://proquest.umi.com/pqdweb?did=1597612421&sid=3&Fmt=2&clientId=1509&RQT=309&VName=PQD.
Pełny tekst źródła"Department of Molecular Biology, Microbiology and Biochemisty." Includes bibliographical references (p. 123-150). Also available online.
Heminger, Katherine Ann. "LOSS OF HDMX LEADS TO ALTERATIONS IN GENE EXPRESSION AND INHIBITION OF CELL GROWTH IN TUMOR CELLS WITH WILD-TYPE p53". Wright State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=wright1175282827.
Pełny tekst źródłaKunnari, A. (Anne). "Genetic, epidemiological and cell culture studies on human resistin". Doctoral thesis, University of Oulu, 2008. http://urn.fi/urn:isbn:9789514289477.
Pełny tekst źródłaTiivistelmä Vereen erittyvä uusi hormoni, resistiini, löydettiin vuonna 2000. Hiirellä resistiinin on havaittu erittyvän rasvasoluista ja sen on arveltu toimivan linkkinä lihavuuden ja insuliiniresistenssin välillä. Ihmisellä resistiinin tehtävä on toistaiseksi huomattavasti epäselvempi ja toisin kuin hiirellä ihmisen resistiinin korkein ilmentymistaso on valkosoluissa. Tämän väitöstutkimuksen tarkoituksena oli selvittää ihmisen resistiinin toimintaa ja erityisesti sen liittymäkohtia tyypin 2 diabetekseen ja ateroskleroosiin. Ensimmäisessä osatyössä on selvitetty resistiini-geenin nukleotidimuuntelun yhteyttä tyypin 2 diabetekseen ja siihen liittyviin tekijöihin diabetespotilasaineistossa. Resistiinin geenimuuntelu ei tulosten perusteella ole yhteydessä tyypin 2 diabetekseen, vaikka sillä näyttääkin olevan vaikutusta plasman resistiini-pitoisuuteen, mikä havaittiin toisessa osatyössä. Geenimuuntelulla oli havaittavissa yhteyttä aivovaltimosairauteen. Kolmannessa osatyössä plasman resistiinipitoisuuden yhteyttä valtimonkovettumatautiin ja sen riskitekijöihin tutkittiin Pohjois-Pohjanmaalta kerätyssä aineistossa (n = 525). Plasman resistiinipitoisuudella ei havaittu itsenäistä yhteyttä kaulavaltimonseinämänpaksuuteen, joka kuvastaa alkuvaiheen valtimokovettumataudin tasoa. Tulehdukselliset merkit kuten veren valkosolujen määrä ja plasman CRP-pitoisuus liittyivät suurentuneeseen plasman resistiinipitoisuuteen mutta insuliiniresistenssimuuttujat eivät. Neljännessä osatyössä tutkittiin resistiinin ilmentymistä. Resistiinin havaittiin ilmentyvän kaikissa keskeisissä valkosolutyypeissä ja lisäksi tulehdustekijät lisäsivät sen tuottoa. Erityisesti neutrofiileissä ja monosyyteissä resistiinin ilmentymistasot olivat korkeita. Endoteelisoluilla selvitettiin resistiinin vaikutuksia ateroskleroosiin liittyviin muutoksiin. Resistiini lisäsi monosyyttien kiinnittymistä endoteelisoluihin, mikä on tyypillinen ilmiö varhaiselle ateroskleroosille. Tämän työn tulosten perusteella ihmisen resistiinillä ei ole merkittävää yhteyttä insuliiniresistenssiin ja tyypin 2 diabetekseen. Sen sijaan havainto resistiinin ilmentymisestä useammissa valkosolutyypeissä, kuin mitä aikaisemmin on raportoitu, ja yhteys tulehdustekijöihin osoittaa, että ihmisen resistiinin toiminta liittyy tulehdustiloihin. Resistiini aiheuttaa myös endoteelisoluissa samanlaisia ateroskleroosille altistavia muutoksia kuin muutkin tulehdustekijät. Tulevaisuudessa plasman resistiini-pitoisuutta voidaan mahdollisesti käyttää tulehdustilojen arvioinnissa
Ramos, Rodríguez Mireia. "β-cells cis-regulatory networks and type 1 diabetes". Doctoral thesis, Universitat de Barcelona, 2020. http://hdl.handle.net/10803/672192.
Pełny tekst źródłaFerguson, Gayle Christy. "The Human Cell as an Environment for Horizontal Gene Transfer". Thesis, University of Canterbury. Biological Sciences, 2002. http://hdl.handle.net/10092/1374.
Pełny tekst źródłaPatel, Amar. "The effects of human heme oxygenase-1 (hHO-1) on wild type and mutant (A30P) alpha-synuclein expression in human neuroblastoma cells /". Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=98762.
Pełny tekst źródłaKito, Masao, Mitsuo Maehara i Kazuyoshi Watanabe. "Three Types of Voltage-Dependent Calcium Currents Developing inCultured Human Neuroblastoma Cells". 名古屋大学医学部, 1999. http://hdl.handle.net/2237/6205.
Pełny tekst źródłaHalsey, Richard James. "Construction and characterization of chimaeric human immunodefiency virus type 1 subtype C Gag virus-like particles". Master's thesis, University of Cape Town, 2006. http://hdl.handle.net/11427/4269.
Pełny tekst źródłaIn this study I explored the possibility of making HIV-1 subtype C Pr55gag-based chimaeric virus-like particles (VLPs) as a boost to the HIV-IC multigene DNA vaccine pTHr.grttnC, which encodes a modified Gag-RT-Tat-Nef fusion protein (GRTTN). Furthermore, an attempt was made to produce VLP analogues to the HIV-IA polyepitope DNA vaccine pTHr.HIVA. A range of in-frame fusions with the C-termini of myristylation-competent p6-truncated Gag and native Pr55gag were made to test how the length of polypeptide and its sequence might affect VLP formation and structure.
Dinh, Louie. "Estimating cell type proportions in human cord blood samples from DNAm arrays". Thesis, University of British Columbia, 2017. http://hdl.handle.net/2429/63224.
Pełny tekst źródłaScience, Faculty of
Computer Science, Department of
Graduate
Li, Min. "Kinetic analysis of Human T-cell leukemia virus type 1 gene expression". The Ohio State University, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=osu1228156327.
Pełny tekst źródłaNakahara, Tomomi. "Modulation of the cell division cycle by human papillomavirus type 18 E4". Kyoto University, 2003. http://hdl.handle.net/2433/148728.
Pełny tekst źródłaNasu, Akira. "Genetically Matched Human iPS Cells Reveal that Propensity for Cartilage and Bone Differentiation Differs with Clones, not Cell Type of Origin". Kyoto University, 2014. http://hdl.handle.net/2433/189661.
Pełny tekst źródłaPeat, D. S. "The effect of herpes simplex virus type 1 on chromosomes of human cells". Thesis, University of Cambridge, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383841.
Pełny tekst źródłaDo, Rosario Yanez Romana de Jesus. "Expression optimization of a human papillomavirus type 16 therapeutic vaccine candidate in Nicotiana benthamiana leaves". Master's thesis, University of Cape Town, 2016. http://hdl.handle.net/11427/23410.
Pełny tekst źródłaPais, Correia Ana Monica. "Biofilm-like extracellular viral assemblies mediate HTLV-1 (human T cell leukemia virus type-1) cell-to-cell transmission at virological synapses". Paris 7, 2009. http://www.theses.fr/2009PA077233.
Pełny tekst źródłaApproximately 20 million people are infected by HTLV-1 (human T cell leukemia virus type-1). Although the majority of infected individuals remain asymptomatic, around 10% will develop HTLV-1-associated disease. HTLV-1 has been described to efficiently propagate through cell-cell contacts. Designated as virological synapses, these cellular contacts exhibit some of the characteristics of immunological synapses. This project has allowed a better comprehension of how HTLV-1 propagates from cell-to-cell and proposes a completely novel concept of virus transmission through 'viral biofilms'. Contrary to what was previously suggested we have shown that HTLV-1 is accumulated at the surface of infected cells, in extracellular viral assemblies. Viral assemblies are composed of extracellular matrix (HSPG agrin, collagen) and linker molecules (galectin, tetherin) that provide the adhesion and cohesion forces needed to maintain viruses at the cell surface. More importantly, we have shown that HTLV- 1 viral assemblies contribute to the majority of virus cell-cell transmission since their removal significantly inhibits infection (« 80%). Viral assemblies, store, concentrate, disseminate and protect the virus. These characteristics recapitulate most of the features of bacterial or fungal biofilms. Therefore, we propose the use of the term 'viral biofilm' to designate this new mode of cell-to-cell virus spread
Kohl, Thomas Oliver. "An investigation into the development of plant-derived vaccines against human papillomavirus type 11 and Cottontail rabbit papillomavirus". Doctoral thesis, University of Cape Town, 2004. http://hdl.handle.net/11427/7433.
Pełny tekst źródłaThe principal object of this thesis was to investigate the feasibility of developing a novel plant-derived vaccine against Human papillomavirus type 11 (HPV -11), the causal agent of genital warts and laryngeal condylomas. A secondary objective was a proof-of-concept study using Cottontail rabbit papillomavirus (CRPV), as this is a viable animal model for human papillomavirus vaccines. Accordingly, I investigated and compared the potential of two different plant expression systems.
Lambeth, Cassandra Rashida De Silva Aravinda Manu. "Interactions between dengue type 3 viruses and human dendritic cells". Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1238.
Pełny tekst źródłaTitle from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Microbiology and Immunology in the School of Medicine." Discipline: Microbiology and Immunology; Department/School: Medicine.
Sayers, Charlotte. "Herpes simplex virus type 1 infection of human keratinocyte cells". Thesis, Imperial College London, 2013. http://hdl.handle.net/10044/1/11112.
Pełny tekst źródłaGreatorex, Jane. "Studies of the dimer linkage of human T-cell leukaemia virus type 1". Thesis, Open University, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298172.
Pełny tekst źródłaYamamoto, Brenda Michiyo. "Molecular Analysis of Human T-cell Leukemia Virus Type 2 Accessory Protein p28". The Ohio State University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=osu1241708950.
Pełny tekst źródłaDoueiri, Rami. "CHARACTERIZATION OF THE HUMAN T-CELL LEUKEMIA VIRUS TYPE-2 P28 ACCESSORY PROTEIN". The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1343453789.
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