Rozprawy doktorskie na temat „Hormones, Sex – Receptors”
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ElBaradie, Khairat Bahgat. "Membrane effects of sex hormones on growth plate chondrocytes". Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/45956.
Pełny tekst źródłaIsaksson, Friman Erika. "Hormonal treatments and the breast : effects on sex steroid receptor expression and proliferation /". Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-182-9/.
Pełny tekst źródłaCluning, Carmel. "Steroid receptor-associated immunophilins : influence of targeted knockdown and altered expression on receptor signalling". University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0215.
Pełny tekst źródłaGoold, Richard David. "Influence of endogenous female sex-steroids on mutagen metabolism". Thesis, Rhodes University, 1985. http://hdl.handle.net/10962/d1004919.
Pełny tekst źródłaKMBT_363
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Trout, Amanda L. "SEX DIFFERENCES IN CELL DEATH AND STEROID HORMONE RECEPTORS IN CORTICAL EXPLANTS". UKnowledge, 2013. http://uknowledge.uky.edu/physiology_etds/6.
Pełny tekst źródłaWilliams, Maro R. I. 1974. "Dehydroepiandrosterone action in the cardiovascular system". Monash University, Dept. of Medicine, 2002. http://arrow.monash.edu.au/hdl/1959.1/7927.
Pełny tekst źródłaTasende, Celia. "Pituitary and uterine sex steriod receptors in ewes : seasonal and postpartum anoestrus, oestrous cycle and experimentally induced subnormal luteal phases /". Uppsala : Dept. of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2005. http://epsilon.slu.se/200597.pdf.
Pełny tekst źródłaMeikle, Ana. "Reproductive endocrinology of prepubertal and anestrous ewes : regulation of uterine sex steroid receptors by ovarian hormones and effects of estradiol on gonadotropin secretion and follicular growth /". Uppsala : Swedish Univ. of Agricultural Sciences (Sveriges lantbruksuniv.), 2001. http://epsilon.slu.se/avh/2001/91-576-5915-X.pdf.
Pełny tekst źródłaCoulombe, Marie-andree. "Implication du sexe, des hormones gonadiques et de leurs métabolites dans la réponse nociceptive et la perception de la douleur". Thesis, Strasbourg, 2013. http://www.theses.fr/2013STRAJ099/document.
Pełny tekst źródłaSeveral biological, psychological, and cultural differences can explain the difference in pain perception between men and women. It is known that gonadal hormones influence the nociceptive response in animals and humans. The brain also has the ability to synthesize its own "sex hormones", also named neurosteroids. The aims of this thesis were: 1) to assess the physiological and psychological factors influencing the difference in pain perception between men and women, 2) to relate the levels of androgens and cortisol with clinical symptoms and pain perception in healthy volunteers and patients with fibromyalgia, and 3) to evaluate the involvement of gonadal hormones and of their 3α5α-reduced metabolites in the transmission of pain and the effectiveness of descending pain modulation systems (DPMS) in males and females using behavioral pain model in rats and mice
Pedroso, Luciana de Britto. "Avaliação da possível diferença na sensibilidade dolorosa de ratos machos e fêmeas e da resposta de cada sexo a crotalfina, um analgésico tipo opióide". Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42136/tde-23012012-114018/.
Pełny tekst źródłaSeveral clinical and experimental evidence have suggested the existence of sex differences in pain sensation and in the analgesic effect of opioid drugs in human and rodents. Crotalphine (CRP), a peptide first characterized in the venom of the South American rattlesnake Crotalus durissus terrificus, displays potent and long-lasting opioid (peripheral k and d opioid receptors) analgesic activity in experimental models of acute and chronic pain. Due to its potent and long-lasting analgesic effect, pre-clinical trials with the synthetic peptide and analogues are now in progress. However, the experimental studies with CRP have always been developed in male animals. This study aims to evaluate the differences in pain sensation and in the analgesic response to CRP between male and female Wistar rats. Sex differences could be observed between male and female rats in relation to pain threshold. However, despite displaying opioid activity, the new analgesic peptide CRP is more effective in females than males. These differences could be related with sex hormones.
Roche, Jennifer. "Implication des récepteurs de la dopamine dans la régulation de l’axe gonadotrope lors de la période pré-ovulatoire chez le sandre, Sander lucioperca". Thesis, Université de Lorraine, 2018. http://www.theses.fr/2018LORR0234.
Pełny tekst źródłaPikeperch, Sander lucioperca, is a potential valuable economic fish, making it a species of interest for aquaculture diversification. In the domestication process, controlling and understanding the reproductive cycle is a crucial step in order to produce viable offspring in a synchronous and predictable way. In many teleosts including some perciforms, dopamine inhibits the ovulatory pulse of LH and the ovulation step through D2 dopamine receptors family. In pikeperch, the roles of dopamine and its receptors, especially those belonging to the D1 receptors family, are unknown. For the purpose of the optimization of pikeperch reproduction, we investigated the role of the dopaminergic system during the final stages of oogenesis in this species: (1) by determining the effects of D1 or D2 receptor antagonists alone or in association with sGnRHa on the regulation of the reproductive axis and on the induction of ovulation, (2) by determining the repertoire and the expression profile of the dopamine receptors using a brain transcriptome analysis during the pre-ovulatory period and (3) by evaluating the role of dopamine and its receptors (D1 and D2 families) in the direct and local regulation of the gonadotropic axis at the brain and ovarian levels. For the first time, we showed that the dopamine/D1 receptors complex regulates the sex-steroids release during the pre-ovulatory period, suggesting that dopamine is involved in pikeperch reproduction. Also, we support its involvement thanks to the identification of the dopamine receptors gene expression at the brain, pituitary and ovarian levels. Finally, we showed that the dopaminergic system directly regulates the ovarian testosterone production, through both D1 and D2 receptor families. The involvement of both dopamine receptor families was also highlighted on ovarian 17β-estradiol production. Only the D2 receptor family was shown to be involved on the brain GnRH-3 gene expression. In conclusion, we point out a dopamine receptors implication on the gonadotropic axis regulation during the final stages of oogenesis in pikeperch. However, further studies should be performed to pinpoint the physiological mechanisms behind this phenomenon. From an aquaculture point of view, hormonal treatments with dopamine receptor antagonists appear to be ineffective to improve pikeperch reproductive performances. Therefore, their use to induce pikeperch ovulation should be put into question and the development of alternative methods is necessary to further promote pikeperch production
Sheppard, Ashley Brianna. "Sex Differences in Nicotine-Conditioned Hyperactivity in a Model of Dopamine D2 Receptor Priming: Roles of Dopamine D2 and D3 Receptor Subtypes". Digital Commons @ East Tennessee State University, 2008. https://dc.etsu.edu/etd/1978.
Pełny tekst źródłaEnglund, Katarina. "Hormonal regulation of sex steroid receptors and growth related genes in human myometrium and leiomyomas /". Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4706-6/.
Pełny tekst źródłaRosenberg, Rachel Stacey. "The effects of plant-derived compounds on sex hormone receptors, implications for hormone-dependent cancer development and treatment". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ29298.pdf.
Pełny tekst źródłaLundqvist, Johan. "Enzymatic Regulation of Steroidogenesis and Nuclear Receptor Activation : Special Focus on Vitamin D and Sex Hormones". Doctoral thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-151740.
Pełny tekst źródłaSabbaghian, Nelly. "Structure-function analysis of three widely dispersed point mutations in the hormone-binding domain of the androgen receptor". Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=68254.
Pełny tekst źródłaPettersson, Hanna. "Steroid-Metabolizing Cytochrome P450 (CYP) Enzymes in the Maintenance of Cholesterol and Sex Hormone Levels". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-100787.
Pełny tekst źródłaDisputationsordförande;Professor Eva Brittebo, Inst. för Biovetenskap, Avd. för Toxikologi, Uppsala Universitet, UppsalaBetygsnämndens ledamöten; Docent Lena Ekström, Inst. för Laboratoriemedicin, Avd. för Klinisk Kemi, Karolinska Universitetssjukhuset, HuddingeDocent Ulf Diczfaluzy, Inst. för Laboratoriemedicin, Avd. för Klinisk Kemi, Karolinska Universitetssjukhuset, HuddingeProfessor Agneta Oskarsson, Inst. BVF, Avd. för farmakologi och toxikologi, SLU, Uppsala. Härtill 4 uppsatser.
Kruijver, Franciscus Petrus Maria. "Sex in the brain gender differences in the human hypothalamus and adjacent areas : relationship to transsexualism, sexual orientation, sex hormone receptors and endocrine status /". [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/75961.
Pełny tekst źródłaHébert-Losier, Andréa 1983. "Structural and functional characterization of a novel endogenous steroid, estradienolone (ED), in human pregnancy". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=116111.
Pełny tekst źródłaYlikomi, Timo. "Sex-steroid-sensitive stromal cells in the chick oviduct and the bursa of Fabricius estrogen-induced and sexual maturation-associated progesterone receptor expression /". Tampere : University of Tampere, 1987. http://catalog.hathitrust.org/api/volumes/oclc/213858363.html.
Pełny tekst źródłaRoseau, Audrey. "Etude de la dynamique des interactions fonctionnelles entre le récepteur de la progestérone et ses corégulateurs transcriptionnels". Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T037.
Pełny tekst źródłaThe progesterone receptor (PR) is a ligand-activated transcription factor playing a crucial role in female reproduction. To regulate gene expression, PR recruits several coregulators to target gene promoters, in a cyclic and combinatorial manner. Among these coregulators, PR recruits most notably members of the p160 family coactivators (Steroid Receptor Coactivators SRC-1, -2 and -3) which have recently been implicated in several hormono-dependent cancers.Here, we studied the mechanisms of interaction between PR and its coregulators as well as their functional consequences on PR transcriptional activity. We have demonstrated that PR activity is paradoxically coupled to the agonist ligand-dependent down-regulation of PR/SRC-1 complexes. Two degradation motifs found in SRC-1 were identified as signals involved in this proteasome- and ubiquitin-mediated process. We also identified a putative candidate implicated in the degradation of these complexes, namely the transcriptional coregulator Jab1. Indeed, Jab1 has previously been described in our laboratory as a coactivator of PR/SRC-1 complexes. We observed that it can specifically regulate SRC-1 and SRC-2 expression in absence of hormone. Finally, we optimized the experimental conditions of FRET experiments to get new insights on the dynamic interactions between PR and its coregulators. Collectively our findings are consistent with the emerging role of proteasome-mediated proteolysis in the gene-regulating process. Understanding PR mechanisms of action is an important step in the development of new therapies, due to growing evidences of PR and its coregulators implication in breast carcinogenesis and metastasis. Deciphering precisely the role of PR coregulators in these processes will permit to define new pharmacological targets for the treatment of these diseases, which represent a serious public health problem
Martínez, Leandro 1979. "Estudo computacional dos mecanismos de dissociação do hormonio tireoidiano de seu receptor nuclear". [s.n.], 2003. http://repositorio.unicamp.br/jspui/handle/REPOSIP/248871.
Pełny tekst źródłaDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Quimica
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Mestrado
Bertrand, Philippe. "Couplages des recepteurs adenohypophysaires a l'adenylate cyclase : caracteristiques, localisation cellulaire et modulation par l'oestradiol". Paris 6, 1987. http://www.theses.fr/1987PA066264.
Pełny tekst źródłaDavid, Daniela Dantas. "Presença do sistema melatoninégico e seu papel no ciclo de muda do siri-azul Callinectes sapidus (Crustacea Brachyura)". Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/41/41135/tde-20092018-111822/.
Pełny tekst źródłaOne of the remarkable morphological and functional features of crustaceans and other arthropods is the presence of an exoskeleton that creates a physical barrier for the animal growth. In crustaceans, molting is a cyclic event usually divided into five stages, one of them comprising the exoskeleton exchange what thus allows the increase in size. The onset, period, and frequency of the molt cycle depend on the animal age and sex, as well as on environmental and physiological factors. Hormones such as ecdysteroids and the molt-inhibiting hormone produced and secreted by the Y- and X- organ, respectively, exert direct effects on the molt cycle. Nevertheless, other hormones are known to positively or negatively regulate this process, such as melatonin. Melatonin is a hormone widely found in the animal kingdom, but in crustaceans, differently from what happens in vertebrates, its synthesis and secretion are not regulated by the presence or absence of light. In fact, its role in the molting process has been poorly investigated. The animals were acclimated in the laboratory at 22±2 °C and light-dark cycle 12h:12h LD, and the experiments were performed under the same condition. Considering the above, the objectives of this study were to: 1) verify the production of melatonin in the blue crab Callinectes sapidus, through the evaluation of the expression of key enzymes involved in the synthesis of melatonin, AANAT and ASMT, in the eyestalk and hepatopancreas, as well as melatonin levels in the hemolymph; 2) evaluate whether there exists a daily oscillatory profile in gene expression of the related molt factors, CasMIH and CasEcR1; (3) whether the exogenous melatonin influences the expression of the latter genes. To achieve these goals, immunohistochemistry, flow cytometry, immunoenzymatic assay, and quantitative PCR techniques were used. Our results demonstrated an oscillation of the hemolymphatic levels of melatonin in premolt crabs, peaking at 8 AM; however, in the intermolt stage, the levels of this hormone were smaller and constant along 24 hours. We were not able to show the presence of the enzymes involved in melatonin synthesis, since the antibodies used had no homology with C. sapidus proteins. We also demonstrated a daily oscillatory profile of CasMIH and CasEcR1 transcripts in hepatopancreas independently of the molt stage. In the eyestalk the oscillatory profile of both genes was also similar, but only in the premolt stage; in intermolt, an antiphase relationship between both genes was found. The exogenous administration of melatonin (10-7 mol/crab) inhibited the expression of CasMIH by 99.7 and 100% in eyestalk and hepatopancreas, respectively, whereas CasEcR1 was inhibited by 77% and 99%, in the eyestalk and hepatopancreas, respectively, compared to saline-treated animals. The presence of melatonin in the hemolymph is a reliable indicator that the animal synthesizes the hormone, and thus melatonin may influence the molt cycle since it inhibited the expression of molt-related genes. Therefore, the relevance of understanding the oscillation of hormones that are not classically involved in the molt cycle - essential for crustacean growth - but which can regulate the process, becomes evident. From an economic standpoint, melatonin may be a useful tool in culturing blue crab, which ultimately can shorten the intermolt stage period leading to an early ecdysis
Schontz, Didier. "Melanome malin : hormonodependance ou independance : differences selon le sexe : recepteurs et traitements hormonaux". Bordeaux 2, 1988. http://www.theses.fr/1988BOR25066.
Pełny tekst źródłaVoorhees, Grace Kathryn. "Understanding the Role of Androgen Receptor Signaling in Modulating p38-alpha Mitogen-Activated Protein Kinase in Experimental Autoimmune Encephalomyelitis". ScholarWorks @ UVM, 2019. https://scholarworks.uvm.edu/graddis/1144.
Pełny tekst źródłaMasseoud, Feda N. "Estrogen-Induced Modulation of Innate and Adaptive Immune Function". Digital Archive @ GSU, 2009. http://digitalarchive.gsu.edu/biology_diss/62.
Pełny tekst źródłaSafi, Rémi. "Etude de la férutinine et de ses analogues : hémisynthèse et activité anticancéreuse vis-à-vis des lignées cellulaires hormono-dépendantes". Thesis, Toulouse 3, 2015. http://www.theses.fr/2015TOU30357/document.
Pełny tekst źródłaEstrogens are key regulators of cell growth in hormone-dependent cancers such as breast, prostate and ovarian. Phyto-estrogens are a diverse group of plant-derived compounds, exhibiting potential benefits for chemoprevention by antagonizing the function of estrogens. Ferutinin (FRT) is the main active phyto-chemical extracted from the endemic plant of Lebanon, Ferula hermonis. Several studies were conducted on the estrogenic and anti-proliferative activities of FRT; nevertheless, its cytotoxic activity against estrogen-dependent cancers is not yet elucidated. FRT has been reported as agonist to estrogen receptor a (ERa) and agonist/antagonist to ERß. FRT production was first optimized by hemi-synthesis from basic hydrolysate of crude root extract. The anticancer properties of FRT was assessed against breast (MCF-7, MDA-MB-231), prostate (PC-3, DU 145, 22Rv1) and ovarian (OVCAR-3, SKOV-3, and IGROV-1) cancer cell lines. A biphasic effect was observed on the proliferation of mammary MCF-7 cell line, where the proliferative activity was correlated to ER stimulation. FRT inhibited the proliferation of all studied cell lines at high concentrations and induced a pre G0/G1 cell cycle arrest via a pro-apoptotic mechanism of action. FRT targeted the enriched population of cancer stem cells/progenitors which is responsible for tumor reemission. However, its antiproliferative activity is considered weak since it cannot trigger at low concentrations pure estrogen antagonistic activity. This project emphasizes next on the synthesis of FRT analogues by preserving its active structure. We have created an in silico filter of chemical compounds that might act as potential antagonists to ERs. This novel molecular docking tool was used to design FRT derivatives by enhancing their antagonist position inside the binding cavity of ERs. Docking results of FRT in the binding site of ERs confirmed structurally the dual potency that exerts this molecule (agonist/antagonist) in vitro. A list of FRT analogues were synthesized and tested for their anti-proliferative activity against the studied cell lines. Promising results were obtained with three ferutinin analogues on the proliferation of breast (3c' and 2c'), prostate (2c') and ovarian (3b) cancer cell lines. These compounds were also shown to be more selective to cancer cell lines. The cytotoxic properties of these analogues suggest that they could be promoted as potential candidates for useful anticancer therapy
Dalmazzo, Andressa. "Imunolocalização e expressão do receptor de ocitocina (OTR) e da globulina ligadora de hormônios sexuais (SHBG) em testículo e epidídimo de cães e suas correlações com a qualidade espermática". Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-30092016-122716/.
Pełny tekst źródłaOxytocin (OT) is a hypothalamic neuropeptide that plays important and well known roles in the female such as uterine contraction during childbirth and milk ejection. Notwithstanding, studies have shown important endocrine and paracrine functions also in the male reproductive tract, highlighted by the possible joint action between OT and sex hormone-binding globulin (SHBG). In dogs, however, there is no information available with regards to the role of these hormones in the reproductive function. Thus, studies directed to oxytocin (OTR) and SHBG receptors and their functions in the male reproductive system, specifically with regards to sperm physiology. Such knowledge is essential to understand the reproductive physiology for the subsequent use in reproductive biotechnologies in small animals and humans, especially by providing new perspectives for the therapeutic use of oxytocin in reproductive disorders. Therefore, the aim of this study is to assess the gene and protein expression of OTR and SHBG in the testis and epididymis of dogs, correlating these data with sperm quality and testosterone dosage. To this end, testis and epididymis were collected from 26 dogs in reproductive age (1 to 5 years). After orchiectomy, collection of sperm from the cauda epididymis was carried out and then the samples were analyzed for computerized motility of semen (CASA), plasma membrane integrity (eosin / nigrosine), acrosome membrane integrity (Fast Green / rose Bengal) and mitochondrial activity (3\'3 Diaminobenzidine). The immunolocalization of OTR and SHBG was performed by immunohistochemistry and immunofluorescence. Gene expression analysis was performed by real time polymerase chain reaction (qRT - PCR). The protein expression was further assessed by Western Blotting. Significant positive correlations were found between the gene expressions of OTR and SHBG in both the testis and epididymis. Furthermore, the OTR expression in testis was positively correlated to sperm with intact acrosome membrane and negatively to the percentage of cells with low mitochondrial activity. On the other hand, testicular SHBG was positively correlated with sperm concentration, percentage of sperm with intact plasma membrane and acrosome, motility, progressive motility and the percentage of RAPID sperm. Also, negative correlation was found between testicular SHBG and the percentage of cells with low mitochondrial activity. Furthermore, in the epididymis, SHBG gene expression was positively correlated to the percentage of cells with intact plasma membrane and protein expression of SHBG in the testis. In relation to the protein expression, the OTR in the testis correlated positively with blood plasma testosterone and negatively with sperm with no mitochondrial activity. In the epididymis, OTR protein expression correlated positively with sperm showing intact acrosome and negatively with cells with no mitochondrial activity. With regards to SHBG proteins expression, there was a positive correlation to SHBG gene expression in the epididymis, normal cells and some patterns of sperm velocity. In the immunohistochemistry, we observed the OTR and SHBG immunostainings in the smooth muscle and Leydig cells of the testis while, in the epididymis, the OTR immunostaining could be observed only in the smooth muscle. Interestingly, there was no immunostaining or protein expression of SHBG in the epididymis. Our results demonstrated that OTR and SHBG are expressed in the testis and epididymis of dogs and are related to important sperm functions, essential for reproductive success
GRIZARD, DELORME GENEVIEVE. "Fonction leydigienne et cryptorchidie experimentale chez le rat". Clermont-Ferrand 2, 1988. http://www.theses.fr/1988CLF2E408.
Pełny tekst źródłaRodrigues, Natália Martins Bittar. "Distribuição da ghrelina e de seu receptor na mucosa gástrica de ratos submetidos ao desmame precoce: efeitos sobre a proliferação celular epitelial". Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-13112012-094406/.
Pełny tekst źródłaIn the present study, we investigated the distribution of ghrelin and growth hormone secretagogue receptor (GHS-R) in the rat gastric mucosa during the third postnatal week, and evaluated the effects of early weaning on these molecules. In addition, we studied whether ghrelin is part of cell proliferation control in gastric epithelium, and to that we used an antagonist. We detected an increase of ghrelin immunolabelled cells in animals submitted to early weaning and observed that GHS-R expression and protein levels of this receptor were not altered by dietary change. The antagonist [D-Lys-3]-GHRP-6 reduced DNA synthesis index. We concluded that ghrelin and GHS-R are distributed in the gastric mucosa during the third postnatal week and that early weaning increases hormone levels in the gastric epithelium, without changing its receptor. We can suggest that such modulation might be involved in the control of cell proliferation, which is essential for stomach development.
Bailleul, Serge. "Heterogeneite des recepteurs aux oestrogenes et a la progesterone dans les tumeurs mammaires humaines : relation avec l'hormonodependance". Caen, 1988. http://www.theses.fr/1988CAEN2026.
Pełny tekst źródłaAmet, Yolande. "Stéroi͏̈des sexuels et glandes à sécrétion externe de la peau : Interactions stéroi͏̈des-récepteurs et répercussions physiologiques". Brest, 1986. http://www.theses.fr/1986BRES2019.
Pełny tekst źródłaLegendre, Marie. "Implication du récepteur de la ghréline en pathologie humaine : caractérisation d’une nouvelle étiologie des maladies de la croissance et de ses mécanismes moléculaires". Paris 6, 2010. http://www.theses.fr/2010PA066297.
Pełny tekst źródłaBreuiller, Michelle. "Les recepteurs adrenergiques dans le myometre humain gravide : implication des recepteurs beta-adrenergiques chez la rate au moment de la parturition". Paris 7, 1988. http://www.theses.fr/1988PA077019.
Pełny tekst źródłaCayrol, Christian. "Recherches sur l'expression fonctionnelle de genomes diploides et polyploides chez l'amphibien urodele, pleurodeles waltl". Toulouse 3, 1986. http://www.theses.fr/1986TOU30020.
Pełny tekst źródłaTusset, Cíntia. "Pesquisa de mutações na neurocinina B e no seu receptor em pacientes com distúrbios puberais centrais idiopáticos". Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/5/5135/tde-03092012-090655/.
Pełny tekst źródłaInactivating mutations of the TAC3 and TACR3 genes, which encode the neurokinin B (NKB) and its receptor, NK3R, respectively, were described in patients with normosmic isolated hypogonadotropic hypogonadism (IHH). Based on these observations, we hypothesized that gain-of-function mutations in the NKB and/or NK3R might be associated with premature activation of GnRH release, leading to gonadotropin-dependent precocious puberty (GDPP). In this study, we investigated the presence of activating mutations and/or polymorphisms in the TAC3 and TACR3 genes in patients with GDPP, and inactivating mutations and/or polymorphisms in these genes in patients with constitutional delay of growth and puberty (CDGP) and normosmic IHH. It was selected 237 patients with idiopathic central pubertal disorders: 114 with GDPP, 50 with CDGP, and 73 with normosmic IHH. Indeed, a group 150 individuals who had puberty at adequate age was used as controls. The coding regions of TAC3 and TACR3 genes were amplified by polymerase chain reaction followed by enzymatic purification and direct automatic sequencing. In silico and in vitro analyses were performed. A new heterozygous variant in the TAC3 gene, p.A63P, was identified in a Brazilian girl with GDPP who had puberty onset at seven years of age. The p.A63P variant was located in the proneurokinin B and in silico analysis suggested that this variant does not alter constitutive splice sites, and it was benign to the protein. The segregation analysis revealed that her mother was heterozygous for the p.A63P variant (who had a normal pubertal development), suggesting that this variant does not play a role in the GDPP phenotype. It was identified a new heterozygous variant, p.A449S, in the TACR3 gene in a Brazilian girl with CDGP, who had puberty onset at thirteen years of age. Conservation degree analysis of alanine at position 449 showed that this amino acid is not a conserved residue among different species. In silico analyses suggested that this new variant does not alter splice sites or affects the structure of NK3R. Indeed, it was identified three new distinct variants in the TACR3 gene, p.G18D, p.L58L (c.172C>T) and p.W275*, in three unrelated males with normosmic IHH. Both p.G18D and p.L58L (c.172C>T) were identified in heterozygous state, and the p.W275* variant was identified in two of these males, since one in homozygous and in another in heterozygous state in association with the silent variant p.L58L (c.172C>T). In silico analyses suggested that p.G18D might be damaging to the NK3R. In vitro studies of this variant (p.G18D) showed that the amount of inositol phosphate (IP) was not significantly different in cells transfected with the p.G18D mutant receptor than in cells transfected with the wild type receptor, indicating that this variant did not alter the function of the neurokinin B receptor. All new variants identified in the TAC3 and TACR3 genes were absent in 300 control alleles. In conclusion, we identified new variants in the TAC3 and TACR3 genes in Brazilian patients with idiopathic central pubertal disorders. We confirm the key role of the NKB/NK3R complex in the etiology of normosmic IHH
Ninov, Kerli. "Identificação de polimorfismos no gene da leptina e de seu receptor em duas linhagens de aves e associação com características de desempenho e carcaça". Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/11/11139/tde-05032007-162413/.
Pełny tekst źródłaThe trend of industry in producing healthier nourishment, with less fat has raised sensibly. The challenge of animal breeding in the current days is to improve carcass quality of chickens with concomitant reduction in the fat content, witch is a consumer\'s demand. Leptin is a polypeptide hormone secreted mainly by adipocytes with an important role in the regulation of food ingestion, energy metabolism energy and reproduction. The leptin (LEP) and its receptor (LEPR) genes are being subject of intense investigation representing excellent candidate genes for fat deposition in the carcass in marker assisted selection programs. The function of those genes has been intensely studied in mammals, however, in birds few studies were accomplished. The present work aimed to investigate the occurrence of polymorphisms in the LEP and LEPR genes in Chickens, and also evaluate the effects of those polymorphisms on performance and carcass traits. Two chicken lines, a broiler (TT) and a layer line (CC) were used to develop an F2 reference population used in the present study. The reference population was developed in the Poultry Genetic Breeding System at Embrapa Suínos e Aves, in Concórdia/SC. Primers were designed for the PCR amplification of the LEP gene leptina and introns 8 and 19 of the LEPR gene. However, after several attempts it was not possible to amplify the genomic DNA or cDNA of the leptin gene. In the intron 8 of the LEPR gene, SNP C352T was genotyped by DNA sequencing of 247 animals of the F2 population. The T allele was associated with greater carcass yield (P=0,0165), breast yield (P=0,0137), grams of crude protein (P=0,0112) and ashes in the carcass (P=0,0150), while the C allele was associated only to liver yield (0,0102). The SNP G915A in the intron 19 was genotyped by PCR-RFLP of 137 animals from the F2 population, the allele A was associated to the feed intake (P=0,0339), the allele G to the lung yield (P=0,287), and the alleles A and G, when in homozigose, were associated with drumstick and thigh yield (0,0302). Because these SNP are located within an intron area, they are not likely directly involved with the associated characteristics, but they can be linked the other mutation located in the regulatory area of the LEPR gene. In the future other polymorphisms should be explored, in the coding regions of this gene, so they can be used as markers associated to performance and carcass characteristics in poultry. In addition, the LEPR gene was located in the ligation map of the chromosome 8 for the Embrapa population. The next step will be to accomplish the analysis of QTL including the SNPs studied as markers.
Roques, Beatrice. "Bases mécanistiques des effets d'un insecticide agrovétérinaire, le fiproni, et/ou de ses métabolites sur la fonction thyroïdienne chez le rat". Thesis, Toulouse, INSA, 2012. http://www.theses.fr/2012ISAT0029/document.
Pełny tekst źródłaThe widely used insecticide fipronil is a thyroid disruptor in rat acting on thyroid hormone hepatic metabolism. In sheep, a more relevant species for the human thyroid regulation, fipronil-induced thyroid-disruption is much more limited. The goal of this thesis was to characterize the mode of action of fipronil on thyroid function at the hepatic level focusing on 1) the potential role of fipronil sulfone, the main fipronil metabolite formed in vivo, and on 2) interspecific differences in terms of fipronil metabolism and/or sensitivity to thyroid disruption that can prejudge of the relevance of the different animal models for the risk assessment of fipronil for human health. Fipronil sulfone was as efficient as fipronil to induce the expression and/or activity of enzymes involved in thyroid hormone or fipronil hepatic metabolism both in vivo in rat and in vitro on hepatocytes. The use of knock-out mice for xenosensors nuclear receptors strongly suggested an implication of the nuclear receptor Constitutive Androstane Receptor and/or Pregnane X Receptor on fipronil-induced thyroid disruption
Walter, Philippe. "Le recepteur de l'oestradiol humain : isolement, sequence et expression de l'adnc et homologie avec l'oncogene erb-a". Université Louis Pasteur (Strasbourg) (1971-2008), 1986. http://www.theses.fr/1986STR13003.
Pełny tekst źródłaCassanelli, Sylvie. "Analyse in situ de l'hétérogénéité d'expression des récepteurs de la progesterone dans les cellules tumorales mammaires". Université Joseph Fourier (Grenoble), 1995. http://www.theses.fr/1995GRE10118.
Pełny tekst źródłaAvet, Charlotte. "Étude des mécanismes contrôlant l'efficacité et la spécificité de la signalisation du récepteur de la GnRH : identification et rôle de la protéine partenaire SET". Thesis, Paris 11, 2013. http://www.theses.fr/2013PA11T091.
Pełny tekst źródłaReproductive function is under the control of the hypothalamic neurohormone GnRH, which regulates the synthesis and the release of pituitary gonadotropins. GnRH acts on a G-protein coupled receptor expressed at the surface of pituitary gonadotrope cells, the GnRH receptor (GnRHR). This receptor, in mammals, is unique because it is devoided of the C terminal tail, which makes it insensitive to classical desensitization processes. Therefore, the mechanisms that regulate the efficacy and the specificity of its signaling are still poorly known. We searched for interacting partners of GnRHR with the idea that these proteins by interacting with the intracellular domains of the receptor could influence receptor coupling to its signaling pathways. Our work identified the first interacting partner of GnRHR: the protein SET. By GST pull down assays, we showed that SET interacts directly with GnRHR through the first intracellular loop of the receptor. This interaction involves sequences enriched in basic amino acids in the receptor and both N- and C terminal domains of SET. We also showed, by co-immunoprecipitation, that GnRHR in its native conformation interacts with the endogenous SET protein in gonadotrope alphaT3-1 cells and, by immunocytochemistry that the two proteins colocalize at the plasma membrane. By developing in the laboratory biosensors tools that allow to measure with high sensitivity and in real-time intracellular variations in calcium and cAMP concentrations, we demonstrated that GnRHR couples not only to the calcium pathway but also to the cAMP pathway in alphaT3-1 cell line, providing for cAMP the first demonstration of such coupling. Using several experimental strategies to reduce or increase receptor interaction with SET (small interfering RNA, peptide corresponding to the first intracellular loop of the receptor, overexpression of SET), we have shown that SET induces a switch of GnRHR signaling from calcium to cAMP pathway. Our results concerning the activity of the Gnrhr gene promoter led us to postulate that SET could favor the induction by GnRH of genes regulated through the cAMP pathway, notably those encoding the GnRHR. Our study also showed that GnRH regulates not only SET protein expression in gonadotropes, but also its phosphorylation level leading to its relocation in the cytoplasm of alphaT3-1 cells. This suggests that GnRH induces a regulatory loop to amplify SET action on signaling of its own receptor. Finally, we demonstrated that SET expression is markedly increased in the pituitary gland at prœstrus in female rats, providing the first demonstration of a variation of SET expression in a physiological context. Given that GnRHR coupling to the cAMP pathway is increased at prœstrus, our results suggest that SET may play an important role in vivo by promoting such coupling at this particular stage of the estrus cycle
Brannan, Katla Jorundsdottir. "Telomerase and its reverse transcriptase subunit TERT : identification and oestrogenic modulation of telomerase transcription in two aquatic test species - European Purple Sea Urchin (Paracentrotus Lividus) and Rainbow Trout (Oncorhynchus Mykiss)". Thesis, University of Exeter, 2012. http://hdl.handle.net/10871/16556.
Pełny tekst źródłaPeycelon, Matthieu. "Mécanismes physiopathologiques impliqués dans la différenciation du tractus génital masculin". Electronic Thesis or Diss., Sorbonne université, 2019. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2019SORUS461.pdf.
Pełny tekst źródłaBackground. Hypospadias is the most common malformation affecting the male genitalia. Although the causes remain often unknown, endocrine, vascular and environmental factors have been implicated. However, the genetic basis is probably underestimated. Objectives. To study the genetic factors implicated in sexual differentiation. Methods. A cohort of 284 children born with hypospadias has been established since 2011. DNA was extracted from blood lymphocytes and fibroblasts obtained after a foreskin biopsy. Sanger sequencing of AR, MAMLD1 and NR5A1, SNP-array analysis, and Whole Exome Sequencing (WES) were performed. A second cohort of 1,311 pregnant women was established to evaluate an association between maternal fhCGb and hypospadias. Results. No mutation in AR and MAMLD1 was found. Non-described variations of AR, MAMLD1 and NR5A1 were identified without any splicing activity. Some polymorphisms in AR gene had a MAF significantly higher (p<0.01). A heterozygous intragenic duplication of NR5A1 was found. Pangenomic analysis included 35 anomalies (15.7%) that could be a potential cause of isolated, distal, non-hereditary hypospadias encompassing 25 candidate genes. 22 variants was classified as pathogenic on WES. Finally, a significant difference of fhCGb for severe types was identified even after adjustment for placenta dysfunction (p<0.03). Conclusion. Our hypothesis about “somatic” mutations in 3 candidate genes was not ascertained. However, pangenomic analysis found 15.7% anomalies which could be likely linked to hypospadias. The use of WES could be an attractive method for exploring further these results as we identified 22 variants in 30 cases of familial hypospadias
Kouidhi-Lamloum, Wided. "Effets de deux xénohormones, la génistéine et la vinclozoline, sur le développement et les fonctions exocrines et endocrines des glandes salivaires submandibulaires de rats Wistar Han : influence de la période d'exposition en fonction de l'âge et du sexe". Phd thesis, Université de Bourgogne, 2012. http://tel.archives-ouvertes.fr/tel-00935290.
Pełny tekst źródłaTomás, Joana Filipa Melfe. "Taste receptors in the Choroid Plexus are functional and regulated by sex hormones". Doctoral thesis, 2020. http://hdl.handle.net/10400.6/11162.
Pełny tekst źródłaOs plexos coróides (PCs) são estruturas altamente vascularizadas localizadas nos ventrículos cerebrais. São constituídos por uma monocamada de células epiteliais cuboides assentes numa membrana basal que está em contacto direto com um estroma altamente vascularizado, com tecido conjuntivo rico em fibroblastos e com células do sistema imunitário. O lado apical destas estruturas está em contacto direto com o líquido cefalorraquidiano e apresenta microvilosidades e alguns cílios. O lado oposto, o lado basal, está em contacto com vasos sanguíneos altamente fenestrados. Os PCs formam vilosidades de modo a aumentar as superfícies de contacto entre as células epiteliais do lado apical com o líquido cefalorraquidiano, e com o fluído intersticial do lado basal. Os PCs são o principal local de síntese de líquido cefalorraquidiano, estão envolvidos na vigilância imunológica do sistema nervoso central, são estruturas ativas na neurogénese e são ainda responsáveis pela remoção de compostos tóxicos e metabolitos do líquido cefalorraquidiano resultantes de processos metabólicos do sistema nervoso central. A sua ultra estrutura é composta por células unidas através de junções de oclusão que permite que este órgão forme uma barreira entre o sangue e o líquido cefalorraquidiano, a barreira sanguelíquido cefalorraquidiano, que previne o movimento de substâncias para dentro e fora do cérebro pelos espaços intercelulares. Tendo em conta a sua estrutura e localização, os PCs têm um papel crucial na monotorização da composição química do líquido cefalorraquidiano e do sangue, contribuindo para a síntese e/ou transporte de compostos essenciais para um normal funcionamento e proteção do sistema nervoso central contra agentes neurotóxicos. A expressão de genes relacionados com a via de transdução de sinal do paladar no PC foi detetada num estudo de microarrays de DNA complementar, realizado previamente pelo nosso grupo de trabalho, em PCs de ratos castrados Wistar Han. Nesse estudo, verificou-se ainda que a via de sinalização do paladar foi uma das cinco vias mais afetadas pelas hormonas sexuais femininas, estando sobre expressa em ratos fêmea ovariectomizados. A expressão da via do paladar tem sido amplamente estudada, fora da cavidade oral, em órgãos como o estômago, intestino, pulmões, coração, testículos, artérias, entre outros. Nestes órgãos, os recetores do paladar parecem funcionar como sensores que monitorizam a composição química dos fluidos biológicos circundantes que, quando ativados, desencadeiam respostas metabólicas defensivas. A via de transdução de sinal do paladar, descrita originalmente nas células sensoriais nos botões gustativos, inicia-se com a ligação das moléculas do sabor ao respetivo recetor do paladar (Tas1r2/Tas1r3 e Tas1r1/Tas1r3, respetivamente para o doce e umami, e Tas2r para o amargo) ativando uma via de transdução de sinal que resulta na despolarização da célula. Os ensaios experimentais apresentados nesta tese tiveram como objetivo geral investigar o papel da via do paladar na capacidade de monitorização da composição química do líquido cefalorraquidiano e/ou sangue por parte dos PCs. Deste modo, o presente estudo teve como objetivos específicos a análise da expressão dos diferentes componentes da via de sinalização do paladar e o estudo da sua funcionalidade no PC de rato, bem como a avaliação da sua regulação pelas hormonas sexuais. No primeiro trabalho desenvolvido, avaliou-se a expressão e a funcionalidade da via do paladar no PC de rato, por RT-PCR e singel cell calcium imagingI, respectivamente. Identificaram-se transcritos de genes da via de sinalização do paladar tais como os recetores do paladar Tas1r1, Tas1r2, Tas1r3, que formam os recetores do doce e umami, os recetores Tas2r109 e Tas2r144 que detetam compostos amargos, e moléculas da maquinaria da via de sinalização (Gustducina, fosfolipase beta 2, inositol tri-fosfato e o membro 5 da subfamília M do canal recetor de catiões com potencial transitório). A expressão das respetivas proteínas foi confirmada por Western blot, imunofluorescência, imunohistoquímica e imunocitoquímica. Uma análise imunocitoquímica de explantes de PC com marcação dupla da proteína alvo (Tas1r3 e Tas2r144) e do marcador de células epiteliais de PC, a transtirretina, revelou que os recetores do paladar estão localizados nas células epiteliais de PC. Uma vez confirmada a expressão de toda a maquinaria da via de transdução de sinal do paladar no PC, procedemos aos estudos funcionais. Sabendo que a maioria dos compostos tóxicos e/ou nocivos correspondem a compostos amargos, selecionámos como alvo do nosso estudo os recetores do amargo, dado que a sua presença no PC poderá estar associada à deteção de compostos neurotóxicos. De modo a avaliar a sua funcionalidade, utilizámos culturas primárias de células epiteliais de PC onde realizámos a técnica de single cell calcium imaging utilizando a D-Salicina como composto amargo. O estímulo com D-Salicina provocou um aumento nos níveis intracelulares do ião cálcio que na presença de um bloqueador de recetores do amargo, o Probenecid, diminuíram de intensidade. Uma vez que a presença de um bloqueador dos recetores do amargo diminui a resposta observada, é muito provável que esta se deva à ativação dos recetores do amargo. Deste modo, podemos afirmar que os recetores do amargo presentes no PC são funcionais, podendo detetar compostos amargos presentes no líquido cefalorraquidiano e/ou no sangue. O segundo estudo desenvolvido, teve por base uma análise de dados de microarrays de DNA complementar de PC de ratos castrados, realizado previamente pelo nosso grupo. A análise in silico destes dados mostrou que o declínio das hormonas sexuais femininas aumentava significativamente os níveis de expressão dos recetores do amargo Tas2r109, Tas2r124, Tas2r134 e Tas2r144, e as moléculas da via de sinalização do paladar Plcb2 e Trpm5. Mostrou também que os recetores do amargo Tas2r109 e Tas2r144 são diferencialmente expressos entre machos e fêmeas, apresentando uma expressão mais elevada nos machos. Deste modo, no segundo estudo apresentado nesta tese, analisámos a regulação da via de transdução do paladar pelas hormonas sexuais femininas. Assim, estudámos a expressão dos genes Tas2r109, Tas2r144, Plcb2 e Trpm5 no PC de ratos fêmea castrados e não castrados e em explantes de PC de ratos recém-nascidos (5-6 dias de idade) incubados com diferentes concentrações de estradiol e progesterona. Os resultados obtidos, in vivo e ex vivo, corroboram os resultados dos microarrays de DNA complementar comprovando a regulação hormonal dos genes da via de transdução de sinal do paladar no PC. O efeito das hormonas sexuais na resposta das células do PC a um estímulo amargo foi avaliado por single cell calcium imaging com o composto Benzoato de Denatónio, um ligando do recetor do amargo Tas2r144, numa linha celular imortalizada de células epiteliais de PC (Z310) em presença de estradiol e/ou progesterona e também na presença dos bloqueadores dos recetores nucleares das hormonas. Observámos que a presença de estradiol e/ou progesterona diminuiu a amplitude de resposta das células Z310. O estudo com os bloqueadores hormonais permitiu-nos concluir que o efeito do estradiol parece ocorrer via recetor nuclear, e os resultados com progesterona sugerem o envolvimento dos recetores membranares da progesterona. Com o objetivo de analisar se as respostas observadas por single cell calcium imaging ocorrem via recetor Tas2r144, realizaram-se ainda ensaios de cálcio com o recetor Tas2r144 silenciado com um RNAi específico. Os ensaios de cálcio após silenciamento do Tas2r144 mostraram uma redução significativa da resposta ao Benzoato de Denatónio, de maneira semelhante aos efeitos do estradiol e progesterona, sugerindo que as hormonas sexuais femininas regulam negativamente as respostas do PC a estímulos químicos, reduzindo a Tas2r144. A regulação exercida pelas hormonas sexuais na resposta a compostos amargos no PC, eventualmente neurotóxicos, poderá estar envolvida na diferença no aparecimento e progressão de doenças do sistema nervoso central entre géneros. Em suma, os nossos resultados confirmam a presença da maquinaria molecular da via de transdução de sinal do paladar no PC de rato, mostrando que a via do amargo está funcional, e revelam a sua regulação pelas hormonas sexuais femininas. Os resultados obtidos neste trabalho suportam a hipótese de que a via de transdução do paladar poderá ser um dos mecanismos utilizado pelo PC para monitorizar o conteúdo químico do líquido cefalorraquidiano e/ou sangue e responder de modo a modular e manter a homeostasia do sistema nervoso central. No futuro, os resultados apresentados poderão contribuir para uma melhor compreensão dos mecanismos por detrás da função do PC em monitorizar/proteger o sistema nervoso central.
Rudolph, Sara. "A review of genetic polymorphisms in the receptors for gonadotropic and sex hormones in polycystic ovary syndrome". Thesis, 2017. https://hdl.handle.net/2144/23991.
Pełny tekst źródłaMcCarthy, Anna R. "Biological activity of steroid analogues : synthesis and receptor/enzyme interactions : a thesis submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Chemistry at the University of Canterbury /". 2006. http://library.canterbury.ac.nz/etd/adt-NZCU20060724.203418.
Pełny tekst źródłaYao, Chun-Lien, i 姚俊蓮. "Mechanism of androgenic inhibition on stress response – the role of sex hormone receptors at the preoptic nucleus". Thesis, 2011. http://ndltd.ncl.edu.tw/handle/63687757940249775385.
Pełny tekst źródła慈濟大學
生理暨解剖醫學碩士班
99
It is well known that there is sexual difference on stress responses. Studies indicate that testosterone (T) has an inhibitory effect on stress-induced hypothalamic-pituitary-adrenal (HPA) activation. Androgen receptor (AR) is found throughout the central nervous system, but the paraventricular nucleus in the hypothalamus (PVH), the integrator of HPA activity, expresses little. Evidence shows that medial preoptic neucleus (MPN), an AR bearing nucleus, may play a critical role on modulating the effects of T on stress-induced HPA axis activation. The mechanism, however, is not clear. Male Spraque-Dawley rats (250-300g) were used in this project. We used 30-min restraint (RST) as the stressor, and the cFos expression by immunohitochemistry (IHC) as the index of neuronal activation. The numbers of cFos-immunoreactivity (-ir) cells at both MPN and PVH in gonadectomized (GDX) and intact rats were similar under non RST condition. But GDX rats showed more cFos-ir cells at both nuclei than intact control after RST challenge. T supplement reversed the promotive effect of GDX on stress-induced neuronal activation. These results indicated that T might tonically inhibit stress-induced HPA activation through inhibiting MPN neurons. Surppissingly, AR blockage did not mimic the phenomena seen in stress suffering GDX rats. It indicated that AR may not be important on T regulating stress response. Moreover, T can be transformed into estradiol (E) by neurons in the MPN. We found that E supplement could reverse the promotive effect of GDX like T supplement. So, T may inhibit stress response, after it is converted into E.
Yeh, Chu-Yin. "Cloning and expression of a corticoid receptor in the sea lamprey (Petromyzon marinus)". Diss., 2008.
Znajdź pełny tekst źródła"Committee members, Weiming Li, Richard Miksicek, and Cheryl Sisk"--Acknowledgments. Title from PDF t.p. (viewed on Aug. 4, 2009) Includes bibliographical references (p. 51-54). Also issued in print.