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Hussein, Mohamed Osman. "Hormonal modulation of Leydig cell membrane luteinizing hormone receptors /". The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487267024995937.
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Kirkpatrick, Bridgette Lee 1966. "Hormonal regulation of gonadotropin releasing hormone receptor expression in the ewe". Diss., The University of Arizona, 1998. http://hdl.handle.net/10150/282660.
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Endocrine regulation of expression of GnRH receptors is an important step in the control of reproduction. During the early follicular phase of the estrous cycle in the ewe, GnRH receptor expression increases in preparation for the preovulatory surge of LH. The studies described herein were designed to further elucidate the hormonal interactions controlling GnRH receptor expression. In long-term ovariectomized ewes, neither removal of progesterone, nor the presence of estradiol affected the expression of GnRH receptors. However, in ewes ovariectomized during the luteal phase of the estrous cycle and immediately implanted with progesterone and estradiol for 48 hours, low levels of estradiol for 24 hours were required to increase GnRH receptor mRNA following the removal of progesterone. In ovariectomized ewes following hypothalamic-pituitary disconnection, low levels of estradiol and pulsatile GnRH were required to increase GnRH receptor expression within 24 hours of treatment initiation. These results suggest an interaction between estradiol and GnRH is involved in increasing GnRH receptor expression during the periovulatory period. How progesterone, estradiol and, GnRH interact to increase GnRH receptors is unknown, but a possible candidate involved in mediating these interactions may be the cell specific transcription factor, steroidogenic factor-1 (SF-1). SF-1 mRNA increased within 24 hours of treatment of ewes with prostaglandin F₂(α) compared to ewes in the luteal phase of the estrous cycle. This suggests that progesterone may have an inhibitory effect on SF-1 mRNA. SF-1 mRNA was similar between ovariectomized ewes and ovariectomized ewes following hypothalamic-pituitary disconnection treated with estradiol and GnRH. Treatment with estradiol or GnRH alone did not increase SF-1 mRNA. The results of these experiments suggest that progesterone removal as well as the presence of estradiol and GnRH are required to increase GnRH receptor expression during the early follicular phase in the ewe. Further, the transcription factor, SF-1 may be involved in mediating the effects of these hormones on GnRH receptor expression.
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Rodrigues, Mark. "Hormonal and non-hormonal factors associated with cognition in post-menopausal women". University of Western Australia. School of Psychiatry and Clinical Neurosciences, 2004. http://theses.library.uwa.edu.au/adt-WU2004.0075.
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[Truncated abstract.] Alzheimer’s disease (AD) is the most common form of dementia world-wide accounting for more than two thirds of all dementia cases. AD is characterised by the presence of extracellular amyloid plaques, neurofibrillary tangles and congophillic amyloid angiopathy in the brain tissue of affected individuals. Of these neuropathological features the extracellular amyloid plaques are the most characteristic containing a peptide termed amyloid- beta (Aβ); the major protein component of these structures. In addition a number of genetic risk factors for AD have been identified. Of these the ε4 allele of the apolipoprotein E (APOE) gene found on chromosome 19 is considered to be the main genetic risk factor attributing to about 40-60% of all AD cases in most populations. Although there is strong evidence that genetic risk factors play an important role in AD they do not actually trigger the disease process. Deficits in memory and learning are the most common clinical signs of AD in the initial stages of the disease. Neuropsychological tests such as the CAMCOG and California Verbal Learning Test (CVLT) are important diagnostic tools used for the assessment of cognition. The CAMCOG is an accurate and efficient measure of global cognitive ability, while the CVLT is more specific to areas of cognition influenced in the early stages of the disease such as verbal memory. Substantial evidence indicates that changes in sex hormones following menopause in women are important factors in AD. Specifically, the reduced levels of oestrogen in post-menopausal women have been linked to cognitive decline and an increased risk of dementia. In addition the elevated level of the gonadotropins, a characteristic of the post-menopausal period, have been implicated with the disease. Numerous nonhormonal factors such as age and education may also be associated with the development and progression of cognitive decline.
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Nyeko, Moini Brian Anyau. "Hormonal Contraceptives for men". Thesis, Uppsala universitet, Institutionen för farmaceutisk biovetenskap, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-422360.
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Background: Contraceptives for men has existed for centuries. However, the only contraceptives available for men are condoms, withdrawal during sexual intercourse or undergoing Vas occlusion. The issues currently with these methods are that many couples are not comfortable with using condoms and vasectomy is a non-reversible contraceptive as it requires surgery. Currently, only research has been made with regards to hormonal contraceptives for men. The basis for hormonal contraceptives for men is that it disturbs hypothalamic-pituitary–gonadal axis, by suppressing GnRH, LH and FSH in order to suppress spermatogenesis. The substances that have been clinically tested as a potential hormonal contraceptive for men are androgens, androgens together progestins and synthetic androgens. Aim: The aim of this thesis was to examine the effectiveness of the substances that have been used in past and recent clinical trials and the adverse drug reactions/effects. Method: Results from the clinical trials were collected through PubMed with regards to preordained criteria, which resulted in 18 scientific articles being used in the results. Results: Overall, the results showed that the majority of substances used in previous and recent clinical trials are effective in suppressing spermatogenesis. The results also showed that a majority of substances used in previous and recent clinical trials had severe adverse drug effects severe amongst the participants. Discussion and Conclusion: In summary, the research shows that amongst the substances used in recent and current clinical trials, that synthetic androgens have the best potential as a hormonal contraceptive for men with regards to effectiveness and adverse drug effects.
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GUENEAU, SYLVIE. "Le cancer du sein chez l'homme : approche hormonale a propos de 20 cas". Aix-Marseille 2, 1990. http://www.theses.fr/1990AIX20151.
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Ligerot, Yasmine. "Rôle des strigolactones dans le développement de l’architecture aérienne de la plante en interaction avec les autres hormones végétales". Thesis, Université Paris-Saclay (ComUE), 2015. http://www.theses.fr/2015SACLS118/document.
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La croissance et le développement des plantes sont sous l’influence de nombreux facteurs génétiques et environnementaux. Parmi eux les hormones végétales participent aux multiples processus qui conduisent à la formation d’une plante via la mise en place d’un réseau complexe d’interactions et de rétro-contrôles. Le contrôle de la ramification implique trois d’entre-elles : l’auxine et les strigolactones (SLs) qui inhibent le démarrage des bourgeons et les cytokinines (CKs) qui le stimulent. Différents mécanismes d’interactions entre ces signaux dans le contrôle de la ramification sont connus. L’auxine contrôle les niveaux de SLs et de CKs, et les voies SLs et CKs convergent vers la même cible, le facteur de transcription BRC1.Chez le pois, les mutants hyper-ramifiés ramosus (rms) sont affectés dans la voie SLs. Les gènes RMS1 (PsMAX4) et RMS5 (PsMAX3) contrôlent la biosynthèse des SLs alors que RMS3 (PsD14) (récepteur) et RMS4 (PsMAX2) sont impliqués dans la perception des SLs. En plus de partager un phénotype hyper-ramifié, les mutants rms présentent un phénotype de nanisme. Cependant le rôle des SLs dans le contrôle de la taille des plantes n’était pas encore connu. Nous avons montré que les SLs contrôlent la taille des plantes en jouant sur le processus de division cellulaire indépendamment de la voie gibbérelline.Les mutants rms montrent des caractéristiques physiologiques similaires : un haut niveau d’expression des gènes de biosynthèse des SL et une faible teneur en CKs dans la sève xylémienne (X-CKs). En revanche, le mutant hyper-ramifié rms2 présente une faible expression des gènes de biosynthèse des SLs et une forte teneur en X-CKs. De précédentes études suggèrent que rms2 est affecté dans un signal tige-racine de rétro-contrôle régulant la biosynthèse des SLs et le niveau de X-CKs. La nature biochimique de ce signal est inconnue et il a été proposé que ce signal soit auxine-indépendant.Nous avons montré que le gène RMS2 est l’homologue chez le pois des gènes AFB4/5 d’Arabidopsis codant pour une protéine à boîte-F de la famille des récepteurs de l’auxine TIR1/AFBs (Auxin signaling F-Box). Ce qui suggère que le signal de rétro-contrôle RMS2-dépendant est l’auxine. De plus nos résultats montrent que les SLs jouent un rôle de répresseur du niveau d’auxine dans la tige via la régulation de l’expression des gènes du métabolisme de l’auxine.L’ensemble de ces résultats montrent que dans le processus de contrôle de la ramification les interactions entre auxine et SLs sont complexes. Les multiples mécanismes en jeux aboutissent à la formation d’une boucle de régulation dans laquelle chaque hormone est capable de contrôler la biosynthèse de l’autreThe different processes of plant growth and development are under the influence of growth regulators which interact in complex hormonal networks and feedback mechanisms. The control of shoot branching involves 3 key plant hormones, auxin, cytokinins (CKs) and strigolactones (SLs). Auxin and SLs repress axillary bud outgrowth whereas CKs stimulate it. Different mechanisms of interactions between these signals have already been suggested in controlling shoot branching. Auxin controls SLs and CKs levels, and SLs and CKs pathways converge on the same target, the TCP transcription factor BRC1 in the axillary bud. In pea, the high shoot branching of ramosus (rms) mutants are known for being impaired in the SLs pathway. RMS1 (PsMAX4) and RMS5 (PsMAX3) genes are involved in SL biosynthesis while RMS3 (PsD14) (receptor) and RMS4 (PsMAX2) are involved in SL perception. In addition to sharing their high branching phenotype, the rms mutants display a dwarf phenotype. However the role of SLs in controlling plant height was unknown. Here we show that SLs control internode length by acting on cell division in a Gibberellin-independent way.The rms mutants show similar physiological characteristics: high expression of the SL-biosynthesis genes and very low xylem-sap CKs (X-CKs) content. In contrast, the rms2 mutant with similar shoot phenotype shows very low expression of SL-biosynthesis genes and high X-CKs content. Previous studies suggested that rms2 was affected in a shoot-to-root feedback signal controlling both SL biosynthesis and X-CKs level. Whether this feedback signal was auxin or not was highly discussed. Here we demonstrated that the RMS2 gene is the pea homologue of the Arabidopsis AFB4/5 gene, encoding an F-box protein which belongs to the TIR1/AFB (Auxin signaling F-Box) auxin receptor family. This suggests that the RMS2-dependent feedback signal is very likely auxin. Moreover our results suggest a role for SLs in the repression of auxin content in pea stem via the regulation of auxin metabolism gene expression. These results highlighted that for the control of shoot branching, interactions between auxin and strigolactones involve multiple mechanisms leading to regulation loop where both hormones are able to regulate the biosynthesis of each other
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Isaksson, Friman Erika. "Hormonal treatments and the breast : effects on sex steroid receptor expression and proliferation /". Stockholm : [Karolinska institutets bibl.], 2002. http://diss.kib.ki.se/2002/91-7349-182-9/.
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Hair, W. Morton. "Studies in male hormonal contraception". Thesis, University of Edinburgh, 2004. http://hdl.handle.net/1842/24662.
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To date androgens remain a central part of any hormonal contraceptive for men although understanding the heterogeneity of the suppression response within populations may require consideration of less orthodox hormonal regulatory systems. Development of minimally invasive, long acting androgen formulations is also necessary to provide an acceptable, convenient and reliable form of androgen delivery which men themselves can administer. Experimental studies in animals have established prolactin as a progonadal hormone in the testis and accessory glands. To explore the role of prolactin in men we investigated the localization and functional activation of the prolactin receptor in the human testis and accessory tissues by immunohistochemistry, RT-PCR and activation of the Janus Kinase/Signal Transducer and Activator of Transcription and Mitogen Activated Protein kinase and Extracellular signal-Regulated Kinase signalling pathways. Expression of prolactin receptor was localized to the Leydig cells and differentiating cells of the testis, the epithelium of vas deferens, epididymis, prostate and seminal vesicles. Functional activation of prolactin receptor was demonstrated in fresh samples of vas deferens. The second study investigated whether concomitant suppression of PRL with the dopamine receptor agonist quinagolide (Q), would enhance the efficacy of testosterone (T) as a contraceptive in men. Volunteers were treated orally with Q, to chronically suppress PRL secretion. A high and an intermediate dose of T was selected to establish whether PRL inhibition would allow use of a lower dose of androgen to induce azoospermia in men. Q did not seem to confer additional efficacy but difficulties in chronic suppression of PRL precludes definitive assessment. The final study describes a clinical trial employing a subject administered, non-invasive hormonal contraceptive regime. Men received transdermal T patches and the synthetic progestagen desogestrel orally in a down ward dose finding study. Transdermal T was less effective than injectable androgen formulations and the minimally effective dose of DSG is 150 mg/day.
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Naguib, Raouf Edouard. "Hormonal modulation of renal autoregulation". Thesis, McGill University, 1995. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=22864.
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Autoregulation of renal blood flow is mediated by two mechanisms. The myogenic response operates at $ approx$0.1-0.2 Hz and tubuloglomerular feedback (TGF) operates at $ approx$0.03-0.05 Hz. Atrial natriuretic factor (ANF) dilates pre-glomerular resistance vessels, in which autoregulation occurs, and has been reported to inhibit TGF. We tested the potential actions of ANF on TGF-mediated autoregulation using Sprague-Dawley rats anesthetized with isoflurane. Renal perfusion pressure (RPP) was manipulated by a servo-controlled clamp placed on the aorta between the renal arteries. Time constants for constriction and dilatation were consistent with operation of TGF. ANF did not affect either the magnitude or the time constants of the response.To test the contribution of TGF resetting to the wide dynamic range of steady state autoregulation experiments, the autoregulatory range was first defined by conventional stepwise reduction of RPP. As ANG II is necessary for TGF resetting, the experiment was repeated in the presence of Losartan, a competitive ANG Il-AT$ sb1$ receptor antagonist. The results do not support the hypothesis that TGF resetting contributes to the wide dynamic range of steady state autoregulation. In fact, the lower limit of autoregulation was extended to a lower RPP. In the Losartan experiment, this shift was not apparent, suggesting that it was ANG II-dependent. (Abstract shortened by UMI.)
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Kunovac, Kallak Theodora. "Hormonal Regulation of Vaginal Mucosa". Doctoral thesis, Uppsala universitet, Institutionen för kvinnors och barns hälsa, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-246215.
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Vaginal atrophy symptoms such as dryness, irritation, and itching, are common after menopause. Vaginal estrogen therapy is the most effective treatment but not appropriate for all women. Women with estrogen-responsive breast cancer treated with aromatase inhibitor (AI) treatment, suppressing estrogen levels, often suffer from more pronounced vaginal atrophy symptoms. However, vaginal estrogen treatment is not recommended, leaving them without effective treatment options. The aim of this thesis was to study the effect of long-term anti-estrogen therapy on circulating estrogen levels and biochemical factors in vaginal mucosa in relation to morphological changes and clinical signs of vaginal atrophy. Circulating estrogen levels were analyzed by use of mass spectrometry and radioimmunoassay. Immunohistochemistry was used to study vaginal proliferation and steroid hormone receptors in vaginal mucosa. Vaginal gene expression was studied by use of microarray technology and bioinformatic tools, and validated by use of quantitative real-time PCR and immunohistochemistry. An estrogenic regulation of aquaporins and a possible role in vaginal dryness was investigated in vaginal mucosa and in Vk2E6E7 cells. Aromatase inhibitor-treated women had higher than expected estradiol and estrone levels but still significantly lower than other postmenopausal women. Aromatase was detected in vaginal tissue, the slightly stronger staining in vaginal mucosa from AI-treated women, suggest a local inhibition of vaginal aromatase in addition to the systemic suppression. Vaginal mucosa from AI-treated women had weak progesterone receptor, and strong androgen receptor staining intensity. Low estrogen levels lead to low expression of genes involved in cell adhesion, proliferation, and differentiation as well as weak aquaporin 3 protein immunostaining. The higher than expected estrogen levels in AI-treated women suggest that estrogen levels might previously have been underestimated. Systemic estrogen suppression by treatment with AIs, and possibly also by local inhibition of vaginal aromatase, results in reduced cell adhesion, proliferation, differentiation, and weak aquaporin 3 protein staining. Low proliferation and poor differentiation leads to fewer and less differentiated superficial cells affecting epithelial function and possibly also causing vaginal symptoms. Aquaporin 3 with a possible role in vaginal dryness, cell proliferation, and differentiation should be further explored for the development of non-hormonal treatment options for vaginal symptoms.
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Smith, Pauline Anne. "Hormonal regulation of barnacle development". Thesis, Royal Holloway, University of London, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.300467.
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Thompson, Melissa Marie. "Males and Male Hormonal Contraception". Kent State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=kent1196792820.
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Oliveira, Sergio Marcelino de. "Controle hormonal da próstata feminina do gerbilo sob influência de múltiplas prenhezes e reposição hormonal". [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317936.
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Orientadores: Sebastião Roberto Taboga, Patrícia Simone Leite VilamaiorTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-18T04:20:43Z (GMT). No. of bitstreams: 1 Oliveira_SergioMarcelinode_D.pdf: 4535012 bytes, checksum: 94d22a407f286cbbf5f47c367a330c46 (MD5) Previous issue date: 2011
Resumo: A próstata feminina (glândula parauretral de Skene) está localizada na parede da uretra feminina e histologicamente possui as mesmas partes da próstata masculina, apresentando um epitélio colunar pseudoestratificado e componentes celulares, enzimáticos e estromais necessários para sua função exócrina e neuroendócrina. O tecido prostático possui uma alta dependência em relação aos andrógenos, e a ação destes hormônios sobre as células prostáticas é mediada via receptor nuclear. Nem todos os tipos celulares prostáticos possuem receptor para andrógenos, sugerindo que somente certos tipos celulares podem ser considerados alvos diretos da ação de andrógenos. A próstata feminina também é alvo da testosterona, pois estudos recentemente publicados demonstram que a reposição hormonal com este hormônio promove o desenvolvimento morfofuncional da próstata feminina em gerbilos. Mesmo sendo a próstata um tecido andrógeno dependente, os estrógenos são necessários para manutenção do seu funcionamento, o que se explica devido a presença dos dois tipos de receptores de estrógeno (ER- alfa e ER-?). Dados recentes da literatura propõem que os hormônios relacionados com a gravidez e ciclo ovariano promovem certo grau de proteção para o tecido da mama contra o câncer e que a aplicação de estradiol e progesterona previne a carcinogênese de mama em ratas nulíparas, mimetizando o efeito da gravidez, e ainda, que tanto o câncer de próstata quanto o câncer de mama, além de serem os principais tumores que incidem em homens e mulheres, respectivamente, e possuírem associações epidemiológicas e etiológicas, apresentam várias anormalidades genéticas em comum. O presente trabalho teve como objetivo avaliar as modificações morfo-funcionais na próstata feminina do gerbilo da Mongólia sob a influência da prenhez e avaliar a influencia desse estágio do ciclo reprodutivo na homeostase dos compartimentos prostáticos das fêmeas velhas. Para tanto, foram utilizados 50 animais, sendo: 5 fêmeas adultas nulíparas (AN); 5 fêmeas adultas multíparas (AM); 5 fêmeas velhas nulíparas (VN); 5 fêmeas velhas multíparas (VM); 5 fêmeas velhas nulíparas (VNT) e 5 velhas multíparas (VMT), as quais receberam suplementação de 0,25ml de testosterona em dias alternados (1mg/kg/dia de cipionato de testosterona em óleo vegetal) por 21 dias; 5 fêmeas velhas nulíparas (VND) e 5 velhas multíparas (VMD) as quais receberam suplementação diária de 0,1ml DHEA (5mg/kg diluída em solução salina) por 21 dias; 5 fêmeas velhas nulíparas (VNE2) e 5 velhas multíparas (VME2), as quais receberam suplementação de 0,1ml de estradiol (10mg/ml de óleo vegetal), em dias alternados, por 21 dias. O grupo VM apresentou uma maior incidência de lesões proliferativas, o que nos leva a concluir que o tecido prostático de fêmeas que passam por sucessivas gravidezes possuem maior probabilidade de serem acometidas por tais lesões. Além disso, a reposição hormonal seja com testosterona, estrógeno ou dihidrotestosterona se mostrou mais agressivo no caso de fêmeas multíparas, pois a incidência de lesões proliferativas foi maior neste grupo
Abstract: The gerbil female prostate is located paraurethrally and has all the main histological components of the male prostate, like secretor epithelium and fibromuscular stroma. This gland, like the prostate in males, is targeted by testosterone action, which promotes morphofunctional development. Furthermore, estrogens are required to maintain the male and female prostate and this gland presents both estrogen receptors (ER-alfa and ER-?). In the present work the structural and morphometric-stereological and serological aspects, as well as the quantification of the incidence, multiplicity and percentage of acini affected by different lesions were analyzed. Fifty senile female gerbils were divided into ten groups (five animals each): Adult nulliparous gerbils (AN) and adult multiparous gerbils (AM); senile nulliparous (SN) and senile multiparous (SM) female gerbils; senile nulliparous gerbils (SND) and senile multiparous gerbils (SMD) that received daily 0,1 ml of DHEA during 21 days; senile nulliparous gerbils (SNE) and senile multiparous gerbils (SME) that received 0,1 ml of ?-estradiol on alternate days during 21 days; senile nulliparous gerbils (SNT) and senile multiparous gerbils (SMT) that received 0,2ml of T (1mg/kg/day) for 21 days. This work was performed to quantify the incidence, multiplicity and percentage of acini affected by different lesions in prostate of nulliparous and multiparous senile female gerbils under different types of hormonal replacement using morphometric, stereological and immunohistochemical techniques and to try to establish a relationship between hormonal serum levels in these groups. The proliferative ratio (PCNA/TUNEL) were higher in al multiparous groups when compared with nulliparous groups, mainly in SMT, the same group where were found higher multiplicity of proliferative lesions
Doutorado
Biologia Celular
Doutor em Biologia Celular e Estrutural
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Meyer, Marc-Étienne. "Les récepteurs des hormones stéroïdes entrent en compétition pour des facteurs intervenant dans leur activité transcriptionnelle". Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR1M199.
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Parini, Paolo. "Hormonal regulation of hepatic cholesterol and lipoprotein metabolism : effects of estrogen and growth hormone /". Stockholm, 1999. http://diss.kib.ki.se/1999/91-628-3372-3/.
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Ildgruben, Anna. "Human vaginal epithelial immunity and influences of hormonal contraceptive usage". Doctoral thesis, Umeå : Klinisk mikrobiologi, enh. för Immunologi och Klin. vetenskap, obstetrik och gynekologi, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-595.
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Li, Yue-Xian. "Pulsatile hormonal signaling: a theoretical approach". Doctoral thesis, Universite Libre de Bruxelles, 1992. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/212925.
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Walton, Melanie Jane. "Novel approaches to male hormonal contraception". Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/29411.
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The principal of male hormonal contraception has been investigated for the past 20 years. This thesis reviews what is known already from the literature and presents the results of three new clinical trials investigating different aspects of this approach. These trials were undertaken by myself as a member of the Contraceptive Development Network research groups at the University of Edinburgh. 1. A randomised single centre study comparing the effects of MENT Ac implants or testosterone pellets in combination with etonogestrel implants on spermatogenesis and androgen dependent tissues. 2. Investigation of the effects of gonadotrophin withdrawal and progesterone on hormone production, metabolism and action in the human testis- a randomised, controlled trial. 3. A single centre study comparing the 24 hour testosterone concentration in two groups of men: men receiving a hormonal contraceptive regime and a control group.
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Erdstein, Julius. "Hormonal regulation of experimental hepatoma growth". Thesis, McGill University, 1985. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=65351.
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Sherazi, Aisha. "Multiple hormonal activities of industrial chemicals". Thesis, Brunel University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324553.
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Riddoch, C. J. "Exercise-induced gastrointestinal symptoms : hormonal involvement". Thesis, Queen's University Belfast, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.335621.
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Tigue, P. J. "Hormonal regulation of mammary gene expression". Thesis, University of Nottingham, 1987. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381461.
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Thomas, Charles Abidemi Adewale. "Synthetic approaches to anti-hormonal steroids". Thesis, City University London, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.316056.
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Sagor, Geoffrey Roland. "The hormonal mechanism of intestinal adaptation". Master's thesis, University of Cape Town, 1985. http://hdl.handle.net/11427/27274.
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The gastrointestinal tract has a large functional reserve. This is particularly true of the small intestine, and early studies by Flint in 1912, showed that dogs could withstand 50%-70% small intestinal resection, returning to normal health after an initial period of weight loss and malabsorption. No doubt, this reserve is in part due to the very high rate of epithelial proliferation in small bowel mucosa. Intestinal adaptation is the result of morphological and functional changes, and while these parameters can be accurately appreciated, the mechanisms by which these changes take place, are still under active investigation. This section summarises the changes, both structural and functional, in the adaptive process, and this is followed by a review of the background work done on the possible mechanism of adaptation. The normal anatomy of intestinal mucosa is however, considered first. Most of the work done to date in the field of intestinal adaptation, involves the small bowel, and this part of the gut will be discussed predominantly, but data available on colonic growth will be mentioned.
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Guinn, G., i D. L. Brummett. "Hormonal Changes in Relation to Cutout". College of Agriculture, University of Arizona (Tucson, AZ), 1989. http://hdl.handle.net/10150/204827.
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Experiments were conducted in 1987 and 1988 to determine whether hormonal changes may be involved in the decreases in growth and boll retention commonly referred to as cutout. Nitrogen deficiency decreased the auxin content and growth of fruiting branches. The auxin contents of fruiting branches, squares, and bolls decreased during the season as the plants entered cutout. ABA in bolls increased slightly, but the ABA content of squares and fruiting branches showed no consistent changes. The results indicate that decreases in auxin (IAA) may be involved in cutout.
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Sakimin, Siti Zaharah. "Hormonal regulation of mango fruit ripening". Thesis, Curtin University, 2011. http://hdl.handle.net/20.500.11937/2008.
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Mango fruit ripen quickly. It is highly perishable. Short shelf life of mango fruit limits its transportation to distant domestic and international markets. The objective of my research was to elucidate the role of changes in endogenous levels of brassinosteroids (BRs), ethylene, abscisic acid (ABA) and/or indole-3-acetic acid (IAA) in modulating the ripening processes of 'Kensington Pride' mango fruit. The endogenous levels of these regulators were regulated using inhibitors of their biosynthesis and/or action to unfold their mechanism in delaying/hastening mango fruit ripening, extending storage life and improving fruit quality as well as to underpin the mode of action of ABA and NO in modulating ethylene biosynthesis and activities of fruit softening enzymes in the pulp during ripening and/or alleviating chilling injury (CI) during cool storage.Higher endogenous level of ABA at the climacteric-rise stage triggered the climacteric peak of ethylene production coupled with a significant quadratic relationship between both of them; suggest that ABA play a key role in modulating mango fruit ripening. The exogenous application of ABA (1.0 - 2.0 mM) promoted skin colour development and fruit softening during ripening, and the trend was reversed with its inhibitor of biosynthesis - nordihydroguaiaretic acid (0.1 - 0.2 mM NDGA). The endogenous level of IAA was higher at the initial stage of ripening and decline over ripening period. The exogenous application of 45 - 60 ng g-1 FW Epi- BL increased the climacteric peak of ethylene and respiration, promoted skin colour, but the changes in the endogenous level of BRs (castasterone and brassinolide) are unlikely to modulate mango fruit ripening as it is present in a trace amounts in mango pulp tissues throughout the ripening period.Exogenous postharvest application of ABA (1.0 mM) increased the climacteric peak of ethylene production through promoting the activities of 1- aminocyclopropane-1-carboxylic acid (ACC) synthase (ACS), ACC oxidase (ACO) enzymes, and ACC content, decreased the fruit firmness with increased exopolygalacturonase (exo-PG), endo-PG and endo-1,4-_-D-glucanase (EGase) activities, decreased pectinesterase (PE) activity in the pulp, higher total sugars and sucrose, advanced degradation of total organic acids, citric and fumaric acid. The application of 0.2 mM NDGA showed reverse trends for these ripening indicator parameters.NO fumigation (20 μL L-1 or 40 μL L-1) was more effective in delaying fruit ripening when applied at the pre-climacteric (PC) stage, than at the climacteric-rise (CR) stage. NO (20 μL L-1) fumigation delayed and suppressed the endogenous ethylene production, activities of ACS and ACO enzymes, and ACC content, rate of respiration, higher pulp rheological properties (firmness, springiness, cohesiveness, chewiness, adhesiveness, and stiffness) with lower activities of exo-, endo-PG, EGase, but maintained higher PE activity in pulp tissues during ripening at 21°C and cool storage (13°C). NO treatments (20 and 40 μL L-1) significantly alleviated CI index during ripening at ambient temperature following 2- or 4-week of cold-stored (5°C) period. All NO fumigation treatments significantly suppressed ethylene production and respiration rates irrespective of cold storage period. NO–fumigated with above 5 μL L-1 significantly delayed fruit softening up to 2 days and retarded colour development, reduced total sugar and fructose concentrations, increased tartaric and shikimic acid at fully ripe stage during ripening period irrespective of cold-stored fruit.In conclusion, the higher levels of endogenous IAA in fruit pulp during the PC stage and the accumulation of ABA prior to the climacteric stage might switch on ethylene production that triggers fruit ripening. There is a significant quadratic relationship between endogenous level of ABA in the pulp and ethylene production during fruit ripening period. Exogenous Epi-BL promoted fruit ripening, whilst, the changes in endogenous levels of BRs are unlikely to modulate mango fruit ripening. Moreover, the exogenous application of ABA (1.0 mM) promoted the activities of ethylene biosynthesis enzymes (ACS and ACO) and ACC content and ethylene biosynthesis as well as endo-PG activity in the pulp, whilst, the NDGA-treated fruit showed the reverse trends. The application of NO fumigation (20 L L-1) at PC stage can be effectively used to delay the fruit ripening up to 2 days at ambient temperature (21°C) and cool-storage (13°C) through suppression the activity of ethylene biosynthesis and softening enzymes and alleviate CI following 2- and 4-week cold storage (5°C) without any adverse effects on fruit quality.
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Castelo-Branco, Flores Camil. "Efectes de la castració i del tractament hormonal sobre el perfil lipídic i hormonal de dones menopàusiques". Doctoral thesis, Universitat de Barcelona, 1992. http://hdl.handle.net/10803/2488.
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Amb l'objectiu de valorar els efectes de la castració quirúrgica i del tractament hormonal substitutiu sobre els lipids plasmàtics i les hormones del feix hipòfisi-gonadal s'estudien 185 dones de raça blanca, sense patologies conegudes i que mai no han rebut medicació estrogènica des de l'inici de llur menopausa. Aquestes 185 dones es distribueixen en 2 subpoblacions:a) MENOPAUSA QUIRURGICA INICIAL (MQI): Les 95 primeres formen part d'un estudi prospectiu on es valora l'evolució dels perfils hormonal i lipidic al llarg dels primers mesos després d'una menopausa quirúrgica. Són doncs dones amb cicles regulars fins la cirurgia i varen controlar-se des del moment 0 de la menopausa.
b) MENOPAUSA ESPONTÀNIA (ME): Aquest grup està format per 90 dones menopàusiques amb ovaris integres. D'aquest mode es pot valorar l'efecte dels ovaris restants a la menopausa i llur producció hormonal sobre el perfil lipidic aixi com els canvis que poden induir sobre el mateix els diferents esquemes de tractament.
Aquestes 185 dones varen ser distribuides de mode homogeni i aleatori en els diversos grups de tractament (THS) i control que es descriuen més endavant segons una taula de randomització.
Els cinc regims estudiats comprenen: un grup (n=33 MQI: 18/ME: 15) pren estrògens conjugats equins (ECE) 0.625 mg/dia en cicles de 25 dies cada mes, un altre grup (n=38 MQI: 21/ME: 17) rep 17-B-estradiol transdèrmic 50 micrograms/dia en cicles de 24 dies al mes, un grup (n=32 MQI: 15/ME: 17) rep ECE 0.625 mg/dia cada dia del mes, totes aquestes pacients també reberen 2.5 mg/dia d'acetat de medroxiprogesterona sequencialment els 12 últims dies de cada cicle, el cuart grup va rebre continuadament ECE i MAP a les mateixes dosis cada dia del mes (n=39 MQI: 29/ME: 19) i l'últim grup (n=43 MQI: 21/ME: 22) fou un grup testimoni lliure de tractament.
En el primer grup de pacients (castrades quan encara tenien cicles regulars) es va determinar el perfil lipidic i hormonal previament a la cirurgia (perfil premenopàusic) i als tres mesos l'intervenció (per situar el nou perfil postmenopàusic) abans d'iniciar l'administració del THS. D'aquesta manera es va fer un "wash out" o rentat de l'estat hormonal previ i ens varem assegurar que els lípids a plasma ja no depenien del perfil hormonal anterior eren estables. A continuació es varen tornar a determinar els perfils lipidic i hormonal als 6 i 12 mesos. En l'altra subpoblació, menopausa espontània, com la menopausa és una situació ja establerta amb temps superior als tres mesos no cal fer cap "wash out" i per a iniciar el THS són prou les determinacions basals. Cal fer esment aquí que cap d'aquestes dones no havia mai rebut THS. Igual que en el cas anterior es varen determinar de nou els perfils lipídic i hormonal als 6 mesos i a l'any d'escomençat el THS.
S'ha determinat tant en les pacients tractades com en les que constituien els grups testimoni els següents perfils:
Perfil lipídic: Colesterol, HDL, LDL, Triglicèrids, Apolipoproteïna A(1), Apolipoproteïna B.
Perfil hormonal: FSH, LH, l7-B-Estradiol, Estrona, Prolactina, SHBG, Testosterona, Androstendiona, dehidroepiandrosterona-SO(4).
Els resultats de l'assaig suggereixen:
1) La dosi de 2,5 mg al dia d'acetat de medroxiprogesterona administrada seqüencialment durant 12 dies de cada cicle es insufi cient per a estalviar a l'endometri de creixements proliferatius i d'hiperplàsies (2 pacients en règim transdèrmic i 1 en oral continuat amb gestàgen seqüencial), però probablement aquesta mateixa dosi sigui segura si s'administra continuadament.
2) El THS en les pautes terapèutiques estudiades i amb els fàrmacs i dosis utilitzats no és desencadenant d'hipertensions ni agreuja les ja establertes. Tampoc pot atribuir-se al THS l'increment del pes detectat a les pacients tractades, car presenten augments de pes inferiors als detectats en els controls.
3) Amb la castració paral.lelament al descens de l'estradiol augmenten intensament les gonadotrofines i s'observa un descens dels nivells de la prolactina. També s'observen nivells significativamente més baixos de testosterona i d'androstenediona suggerint doncs un paper important de l'ovari en la síntesi d'aquests esteroïds. També en mancar l'estímul dels estrògens i en ser la relació andrògens/estrògens favorable als primers és lògic el descens de la SHBG. Tanmateix, les modificacions observades a la DHEA-S04 a les pacients després de la castració no són significatives, essent els ovaris poc rellevants a la seva síntesi.
4) Independentment del tipus de menopausa tots els tractaments són igual d'efectius en produir descensos dels nivells de les gonadotrofines i augments de l'estradiol. Paral.lelament es detecta un augment significatiu en l'estrona i SHBG en tots els grups tractats. Aquest augment és molt superior en l'estrogenoteràpia per via oral, tant que les diferències amb la transdèrmica arriben a ser significatives. El THS provoca descensos significatius de la prolactina i escases modificacions en els nivells d'andrògens (testosterona, androstenediona i DHEA-s) tant a les dones amb MQI com a les dones amb ME.
5) Amb l'ooforectomia bilateral no s'observen modificacions del colesterol total. Tanmateix en la fracció RDL hi ha un descens significatiu i en la LDL un augment significatiu en tots els grups als 3 mesos després de la cirurgia situació es manté en el grup control als 6 i 12 mesos del seguiment. Els triglicèrids després de la cirurgia no presenten canvis importants. L'apolipoproteina A-I presenta una tendència al descens que no és significativa i l'Apo B presenta canvis discrets i en sentit contrari. Amb la HQI s'observa un ascens important i significatiu de l'índex aterogènic als 3 mesos de l'ooforectomia que a l'any supera els límits recomenats (IA = 4,24). Aquests resultats indiquen que l 'ooforectomia bilateral comporta una sèrie de canvis metabòlics associats amb el risc cardivascular.
6) En el nostre estudi s'ha detectat poques modificacions amb el THS en el colesterol total però és interesant comentar també que això es degut a que els descensos de la fracció LDL s'han "compensat" amb augments paral.lels de les RDL. El THS no sembla afectar els triglicèrids de les dones de l'assaig en els règims per via oral, mentre que la via transdèrmica va presentar disminucions significatives. Amb el THS s'observa una tendència a l'augment de l'Apo A-I i al descens de l'Apo B. En la nostra sèrie els augments de l'Apo A i de l'HDL, s'observen més intensos en els grups de tractament oral continuat, fet que reforça l'hipòtesi de que sent la menopausa una situació de carència hormonal permanent, la substitució permanent presenta també avantatges a nivell metabòlic. El THS indueix als 12 mesos descensos importants en l'índex aterogènic. L'absència del THS, indueix increments al voltant o superiors al 20%. El grup d'administració continuada d'estrògens i gestàgens és el que presenta a la fi de l'estudi els valors d'índex aterogènic més baixos, donant a aquest règim terapèutic un argument més per a la seva utilització.
7) Les correlacions detectades suggereixen que l'atur del funcionament ovàric o la castració amb l'estat d'hipoestrogenèmia resultant poden ser responsables almenys en part de l'augment del colesterol i sobre tot de les LDL que és típic de les dones postmenopàusiques.
185 postmenopausal women, (95 who had undergone hysterectomy and bilateral oophorectomy -HBO- and 90 who had had natural menopause -NM-) were asked to participate in this study. Patients were allocated at random to one of 5 groups. The five different regimens comprised one group (n=33 HBO:18/NM:15) on conjugated equine estrogens (CEE) 0.625 mg/day over a 25-day cycle each month, one group (n=38 HBO:21/NM:17) on transdermal 17-B-estradiol 50 ~g/day over a 24-day cycle each month, one group (n=32 HBO:15/NM:17) on CEE 0.625 mg/day every day of the month, all these patients also received 2.5 mg/day of medroxiprogesterone acetate sequentially for the last 12 days of each cycle, the fourth group received continuously CEE and MAP at the same doses every day of the month (n=39 HBO:29/NM: 19) and the last group (n=43 HBO:21/NM:22) was a treatment free control group. Hormones (FSH, LH, E(2) , E(1), prolactine, androstendione, testosterone, DHEA-S04 , SHBG) and plasma lipids (Cholesterol, HDL, LDL, triglycerides, Apo A-I, Apo B) were determined before oophorectomy, at 3 months (prior therapy) & repeated after 6 and 12 months. Conclusions: 1) 2.5 mg/day of MAP was clearly an inadequate dose in sequential regimes to protect endometrium against hyperplasic changes, 2) HBO and NM patients showed the same trends with HRT: increases in E(2), E(l), SHBG, HDL, Apo A, decreases in FSH, LH, prolactine, Apo B, LDL, CHOL (NM), triglycerides (transdermal), and no changes in androstendione, testosterone, DHEA-So4' triglycerides (oral) and CHOL (HBO). HBO implies: increases in FSH, LH, LDL, Apo B, decreases in E(2) , E(l), SHBG, prolactine, androstendione, testosterone, HDL, Apo A, and no changes in DHEA-SO(4) triglycerides and CHOL.
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Rice-McDonald, Glenn Gordon. "The hormonal influences on asthma in women /". [St. Lucia, Qld.], 2004. http://www.library.uq.edu.au/pdfserve.php?image=thesisabs/absthe17640.pdf.
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Taher, Mohammed Ahmed A. "Hormonal regulation of ATP binding cassette transporters". [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971837139.
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Hughes, Qunitin William. "Hormonal regulation of the anticoagulant Protein S". University of Western Australia. School of Surgery and Pathology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0247.
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[Truncated abstract] Every year thousands of individuals suffer from thrombotic related complications that in some cases can be fatal and every year millions of women take some form of hormonal contraceptive. In some cases, there is a cause and effect relationship between the two as users of the combined oral contraceptive pill have an increased risk of developing a thrombotic event. Increased circulating levels of oestrogen cause a prothrombotic shift in the coagulation cascade resulting from upregulation of several procoagulant proteins and a decrease of key anticoagulant proteins. One of the most oestrogen sensitive anticoagulants is Protein S (PS), a product of the PROS1 gene. PS acts as a cofactor to activated protein C (aPC) and the PS-aPC complex serves to downregulate clot formation by deactivating the tenase and prothrombinase complexes via proteolytic cleavage of activated factors VIII and V, respectively. As such, low PS levels are associated with an increased risk of developing thrombotic disorders such as pulmonary embolism, stroke or coronary thrombosis and deep vein thrombosis. During pregnancy when oestrogen levels increase, a steady decline in PS is evident in the early weeks of gestation and continues to decrease to below the normal range in the 2nd trimester, remaining there until post-partum. In addition, reduced free and total PS levels are observed in users of the combined oral contraceptive (COC) pill that contains an oestrogen and a progestin. Interestingly, users of 3rd generation COCs have significantly greater reductions of PS than do 2nd generation COC users. The difference between the two forms is the type of progestin, not the oestrogen, which is predominantly ethinyl oestradiol in the majority of commercially available preparations. At present, a mechanism to describe the relationship between oestrogen and/or progesterone associated with the observed in vivo changes in the levels of PS has not been identified. The aim of this thesis was to define the molecular mechanisms involved in the regulation of PS expression by oestrogen and progesterone. In this study, a Combined Single-stranded conformational analysis and Heteroduplex Analysis (CSHA) iv methodology was optimised for screening both PROS1 DNA and mRNA for the detection of mutations. '...' This may explain why users of 3rd generation COCs display a greater reduction in circulating PS levels compared to 2nd generation users. To investigate potential PS interactions with other proteins that could be hormonally regulated, a yeast-2-hybrid (Y-2-H) screen was performed using the PS molecule as a 'bait' against molecules derived from liver and bone marrow cDNA libraries. A clone that contained a portion of another haemostatic protein, Protein Z (PZ) was isolated and confirmed via sequencing. As no full length PZ clones were identified, a second Y-2-H screen was performed once again using the PS molecule as bait and the PZ molecule as the fish. Interaction between the two proteins was shown to be possible via the successful growth of colonies on triple knock out selective media and by positive ß-galactosidase activity.
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Ngo, Phuong. "Hormonal regulation in early pea fruit development". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0009/MQ60160.pdf.
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Young, A. H. "Hormonal effects on brain 5-HT function". Thesis, University of Edinburgh, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.664142.
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The purpose of the work carried out in this thesis was to examine hormonal effects on central nervous system serotonergic (5-hydroxtryptamine; 5-HT) receptor function. Experiments were carried out using established rodent (mouse and rat) models of central 5-HT receptor function. Corticosteroids were administered, both acutely and chronically, and the effects on these models assessed. Corticosteroids were found to have relatively selective effects: in the mouse and rat certain models of 5-HT1A receptor function were attenuated and in the mouse corticosteroids enhanced behavioural models of 5-HT release. No effects were found on models of other central 5-HT receptor functions. These effects were found to be both time and dose dependent and to reverse after the administration of corticosteroids ceased. Removal of endogenous corticosteroids, by adrenalectomy, was found to cause an enhancement of 5-HT1A receptor function. A sex difference, in rodents, in 5-HT1A receptor function was found which was abolished by ovariectomy. The action of corticosterone in producing these effects could not be replicated by selective corticosteroid receptor antagonists. Further experiments were carried out in healthy human male volunteers. Buspirone was shown to induce a hypothermic response significantly greater than placebo. The effects of hydrocortisone administration (20mg, orally, twice daily) on the sensitivity of brain 5-HT1A receptors in healthy volunteers were then studied using a buspirone challenge paradigm. These experiments show that the effects of corticosteroids are relatively selective to 5-HT1A receptors. The effect of corticosteroids on 5-HT1A receptors may be the mechanism whereby exogenous corticosteroids affect mood. Furthermore, the effects of endogenous corticosteroids on 5-HT receptor function may be important in the pathophysiology of mood disorders.
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Blostein, Ashley C. "Effects of running on hormonal growth factors". Virtual Press, 1993. http://liblink.bsu.edu/uhtbin/catkey/865946.
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To determine the influence of running on certain blood-born parameters that are involved in bone metabolism, serum levels of calcium, alkaline phosphatase (ALP, a marker of bone formation), growth hormone (hGH), and parathyroid hormone (PTH), were analyzed in 10 male subjects following a 40 min. run at 70% VO2max. Each trial was preceeded by 1 day of inactivity, a 8-12 hr. fast, and drawing of a baseline blood sample by venipuncture. All other blood samples were taken via an indwelling catheter which was inserted in an antecubital vein immediately following the completion of the exercise bout. When the catheter was in place, an "immediate post" sample was drawn. Subsequent samples were taken at 1, 2, 3, 4, 5, 10, 15, 20, 30, 45, and 60 min. after the immediate post sample. Analysis of serum calcium concentrations demonstrated that levels were significantly elevated by 12% following exercise, going from a fasted level of 9.7 ± .53 mg/dl to post-exercise levels of 11.8 ± .73 mg/dl. Serum calcium remained elevated during the first 4 min. following exercise. By 5 min. post-exercise, calcium levels dropped to levels that were significantly lower than the post-exercise sample. However, serum alkaline phosphatase did not change significantly following exercise, as the values remained within normal range throughout the experimental period. Concentrations tended to decrease over time but were not significantly lower than the preor post-exercise levels by the end of the sampling period. Serum concentrations of hGH were more than doubled following a single bout of exercise, going from 4.0 ± 0.98 ng/ml before exercise to 8.8 ± 1.6 ng/ml immediately post-exercise. Following this initial rise, hGH progressively declined and returned to baseline values by 30 min. post-exercise. The concentrations of PTH did not change significantly following exercise. The postexercise sample tended to be higher than baseline values but were not significantly different. The results presented here indicate that an exercise bout 40 min. at 70% V02max results in an elevation of serum calcium and hGH, but does not alter PTH secretion or ALP activity. The data presented in this study indicate that the temporary rise in calcium following exercise is unrelated to PTH. It is hypothesized that the increase in calcium that we observed is attributable to lactate accumulation that would result from an exercise bout of this nature. The buildup of lactic acid and drop in pH causes a dissolution of the crystaline calcium hydroxyapatite compartment of the skeleton, thus causing an increase in ionized calcium. It is not known whether a single bout of exercise can influence hormonal secretion to a sufficient degree to affect bone density, but the hormonal changes demonstrated here could be involved in long-term effects of training.School of Physical Education
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Federici, Fernán. "Hormonal regulation of cell division in roots". Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608578.
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Batarda, Marisa Alexandra Rodrigues Soares. "Tromboembolismo venoso associado à contracepção hormonal combinada". Master's thesis, Universidade da Beira Interior, 2010. http://hdl.handle.net/10400.6/751.
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Introdução: A contracepção hormonal combinada (CHC) foi introduzida no fim da década de 50 e ainda no início da década de 60 foram descritos casos de tromboembolismo venoso (TEV) associados ao uso de CHC. Em 2003 a Organização Mundial de Saúde (OMS) desenvolveu uma lista de recomendações para a adequação da prescrição de CHC ao perfil individual de risco de TEV, com vista a diminuir a sua ocorrência e consequências.
Objectivo: Avaliar a adequação da prescrição da CHC ao perfil individual de risco de TEV.
Métodos: Realizaram-se dois estudos descritivos em paralelo. Um estudo incluiu 50 mulheres em idade fértil que faziam terapêutica de CHC, entrevistadas para avaliação do seu perfil de risco de TEV, de acordo com a OMS. O outro estudo, do tipo “série de casos”, incluiu todas as doentes do sexo feminino internadas no Centro Hospitalar da Cova da Beira (CHCB) entre 01 de Julho de 2008 a 30 de Junho de 2009, com o diagnóstico clínico de TEV, para avaliar a história de exposição a factores de risco de TEV, nomeadamente CHC.
Resultados: Das 50 entrevistadas que faziam CHC, 35 (70,0%) apresentavam factores de risco de TEV. Destas, 10 (20,0%) possuíam um perfil de risco de TEV classificado nas categorias 3 ou 4 da OMS. Quando questionadas sobre o conhecimento dos diversos factores de risco de TEV associados ao uso de CHC, 27 mulheres (54,0%) sabiam que as veias varicosas aumentavam o risco de TEV. As inquiridas com factores de risco identificados, tinham conhecimento dos mesmos em 33 casos. As 25 mulheres (50,0%) classificadas nas categorias 1 e 2 da OMS apresentavam “prescrição de CHC adequada ao perfil individual de risco de TEV”. Das pertencentes às categorias 3 e 4 da OMS, 9 mulheres (18,0%) apresentavam “prescrição de CHC não adequada ao perfil individual de risco de TEV”.
Conclusões: A prescrição de CHC nem sempre é adequada ao perfil individual de risco de TEV. As mulheres não são convenientemente informadas desse risco e as que são nem sempre se encontram receptivas a métodos alternativos de contracepção. Os clínicos deverão ter em atenção à necessidade de maior cuidado na adequação da prescrição de CHC ao perfil individual de risco de TEV, apesar de, em termos absolutos, o impacto do uso de CHC na ocorrência de episódios de TEV ser pequeno.Background: Combined hormonal contraception (CHC) was introduced in the late 50s and in the early 60s episodes of venous thromboembolism (VTE) were reported in women using this method for contraceptive purposes. In 2003 World Health Organization (WHO) developed a graded list of recommendations according to individual risk profile of VTE, for clinicians to consider when prescribing the CHC, in order to reduce its incidence and consequences. Objectives: To assess the appropriateness of CHC prescribing according to individual risk profile of VTE. Methods: We conducted two descriptive studies in parallel. One study included 50 women using CHC, interviewed to assess their individual risk profile of VTE, according to WHO criteria. The other study, a “case series”, included all female patients hospitalized in “Centro Hospitalar da Cova da Beira (CHCB)” between 1 st July 2008 and 30th June 2009, with clinical diagnosis of VTE, to assess their history of exposure to VTE risk factors, particularly CHC. Results: Of the 50 interviewed women using CHC, 35 (70.0%) had risk factors for VTE. Of these, 10 (20.0%) had a risk profile for VTE classified in WHO category 3 or 4. When asked about their knowledge of different risk factors of VTE associated with CHC use, 27 women (54.0%) knew that varicose veins increase the risk of VTE. Respondents with identified risk factors knew it in 33 cases. The 25 women (50.0%) in WHO categories 1 and 2 had a “CHC prescription adjusted to individual risk profile of VTE”. From those belonging to WHO categories 3 and 4, 9 women (18.0%) had a “CHC prescription not adjusted to individual risk profile of VTE”. Conclusions: The prescription of CHC is not always appropriated to the individual risk profile of VTE. Women are not properly informed of this risk, and those who are sometimes are not receptive to alternative methods of contraception. Clinicians should be aware of the need for improving care and adjust CHC prescribing to individual risk profile of VTE, although in absolute terms the impact of the use of CHC in VTE episodes is small.
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CLAVEAU, CHRISTOPHE. "Metastases surrenaliennes des carcinomes et retentissement hormonal". Angers, 1990. http://www.theses.fr/1990ANGE1022.
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Janssens, Markus Peter-Erik. "Hormonal control of flight metabolism in Odonata?" Master's thesis, University of Cape Town, 1995. http://hdl.handle.net/11427/21424.
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Members of the AKHIRPCH family of peptides were identified in corpora cardiaca of the dragonfly Anax imperator (Anisoptera: Aeshnidae), Orthetrumjuliajalsum (Anisoptera: Libellulidae) and the damselflies Pseudagrion inconspicuum and Ischnura senegalensis (Zygoptera: Coenagrionidae). After isolation ofthe peptides by reversed phase high performance liquid chromatography, the primary structures were established by Edman sequencing and mass spectrometry (Ani-AKH: pGlu-Val-Asn-Phe-Ser-Pro-Ser-TrpNH 2 ), (Lia-AKH: pGlu-Val-Asn-Phe¬ Thr-Pro-Ser- TrpNH 2 ) and (Psi-AKH: pGlu- Val-Asn-Phe- Thr-Pro-Gly- TrpNH 2 ). One corpus cardiac of A. imperator contains about 40 pmol Ani-AKH, O. julia 19-24 pmol Lia¬ AKH and P. inconspicuum about 2.4 pmol Psi-AKH. Injection of Ani-AKH (3.4 pmol) increased the concentration of haemolymph lipids in A. imperator. Lia-AKH (l pmol) similarly had an adipokinetic effect in 0. julia. Psi-AKH (I pmol) had an adipokinetic effect, as well as a small hyperglycaemic effect in P. inconspicuum. The AKH peptides of other Odonata were investigated. In the suborder Anisoptera, Ani-AKH was identified in representatives of the Aeshnidae, Cordulegasteridae, and possibly the Corduliidae. Lia¬ AKH was identified in representatives of the Libellulidae and Gomphidae. In the suborder Zygoptera, Psi-AKH was identified in representatives of the families Chlorolestidae, Lestidae and Chlorocyphidae, and possibly the Calopterygidae and Protoneuridae. Classification of Odonata according to their flight behaviour as "perchers" or "fliers" is supported by parameters of energy metabolism. Lipid metabolism seems to have a greater importance in fliers than perchers. The lipid concentration in the haemolymph is highest in the flier A. imperator, intermediate in the percher 0. julia and lowest in the percher P. inconspicuum. There are indications that mitochondria isolated from flight muscles of A. imperator may have a higher capacity for lipid oxidation than 0. julia. The contribution of carbohydrates to flight metabolism seems to be more important in perchers than in fliers. The concentration of carbohydrates in the haemolymph is highest in P. inconspicuum, intermediate in O. julia and lowest inA. imperator. The maximal activity of phosphofructokinase (a rate-limiting enzyme of glycolysis) is higher in the percher, O. julia, than in the flier, A. imperator. The lipid concentration in the haemolymph is higher than that of the carbohydrates in O. julia, A. imperator and P. inconspicuum. Palmitoyl-carnitine is oxidised at high rates by isolated mitochondria from flight muscles of O. julia andA. imperator, similar to Locusta migratoria. Lipid is the major fuel utilised during flight in O. julia. Carbohydrates (in the haemolymph) and proline (in the haemolymph and flight muscles) are utilised as minor fuels. It is concluded that the processes of lipid metabolism provide the major source of energy during flight in Odonata. The AKH peptides seem to play a role in regulating lipid mobilisation during flight in Odonata.
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BAUMANN, BILLMANN VALERIE. "Traitement hormonal substitutif lors de la menopause". Université Louis Pasteur (Strasbourg) (1971-2008), 1989. http://www.theses.fr/1989STR15002.
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Charles, Nora. "Hormonal influences on sex-linked sexual attitudes". [College Station, Tex. : Texas A&M University, 2008. http://hdl.handle.net/1969.1/ETD-TAMU-2820.
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Sukiran, Nur Afiqah Binti. "Exploring plant hormonal signalling through chemical perturbation". Thesis, Durham University, 2018. http://etheses.dur.ac.uk/12625/.
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Plant growth and development is tightly regulated by a set of plant hormones that includes abscisic acid (ABA) and gibberellic acid (GA). Understanding how this is achieved is challenging due to a complex interplay between the various signalling pathways involved. A chemical genetics approach was used in this study to explore this hormonal crosstalk with a focus on plant growth. A small library of analogues, modified from the calmodulin inhibitor W7, was generated and the effect of these compounds was tested in root growth assays. One particular compound, eW5, was identified as providing enhanced and prolonged root growth even when plants were subsequently removed from the compound. Further analysis suggested that the phenotype induced upon eW5 application was due to modification of DNA methylation. Therefore it was hypothesized that eW5 might affect gene expression, which was tested using a RNA-seq experiment. Results from this suggested that eW5 regulates hormone signalling pathways, with a particular positive correlation to the GA signalling pathway observed. Interestingly, eW5 binds to the ABA receptor PYR1, thus potentially functioning as an ABA antagonist and also promotes DELLA (a negative regulator of plant growth) degradation, in a similar fashion to that observed with GA. Further work was performed to investigate the effect of eW5 on ABA and GA independent pathways. In ABA signalling, eW5 showed inhibition of some ABA responses such as stomatal opening, however no recovery in PP2C phosphatase activity suggests that it does not promote growth by inhibiting ABA perception. In addition, due to the specific GA-mediated response in hypocotyl growth, the eW5 effect was further explored in this particular process. With regard to eW5’s potential role in GA signalling, it was found to enhance sensitivity to GA that leads to DELLA protein degradation and growth promotion. Moreover, it was suggested that the promotion of eW5 in stomatal opening occurs through GA signalling. Having established the positive effect of eW5 on root and hypocotyl growth and stomatal opening, a further small library of analogues of eW5 was generated to further explore its mode-of-action. The position of sulfonamide was identified as a potential site that is responsible for hypocotyl growth promotion.
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Halson, Shona L. "Performance, metabolic and hormonal alterations during overreaching". Thesis, Queensland University of Technology, 2003. https://eprints.qut.edu.au/15790/1/Shona_Halson_Thesis.pdf.
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Many athletes incorporate high training volumes and limited recovery periods into their training regimes. This may disrupt the fragile balance and the accumulation of exercise stress may exceed an athlete's finite capacity of resistance. A state of elevated fatigue, increased mood disturbance and decreased exercise performance can result. This is commonly known as overreaching and if increased training and limited recovery is continued, it is believed that the more serious state of overtraining may develop. This is relatively commonly experienced in athletes, however little scientific investigation has been conducted to determine the characteristics and underlying mechanisms. The overall aim of this thesis was to gain a greater understanding of the state of overreaching and to specifically provide new information on potential markers of this state as well as possible mechanisms. To study the cumulative effects of exercise stress and subsequent recovery on performance changes, fatigue indicators and possible mechanisms, the training of endurance cyclists was systematically controlled and monitored in two separate investigations. A number of variables were assessed including performance, physiological, biochemical, psychological, immunological and hormonal variables. In addition heart rate variability and serotonergic responsiveness were also assessed. Some of the more pertinent effects of overreaching included an increase in heart rate variability, a reduction in carbohydrate oxidation, an increase in serotonergic responsiveness and a reduction in stress hormone concentrations. These results suggest that autonomic imbalance in combination with decreased hormonal release appears to be related to the decline in performance and elevated fatigue apparent in overreached athletes. Additionally it also appears that alterations in the hypothalamic-pituitary adrenal axis may occur in overreached athletes.
42
Halson, Shona L. "Performance, metabolic and hormonal alterations during overreaching". Queensland University of Technology, 2003. http://eprints.qut.edu.au/15790/.
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Many athletes incorporate high training volumes and limited recovery periods into their training regimes. This may disrupt the fragile balance and the accumulation of exercise stress may exceed an athlete's finite capacity of resistance. A state of elevated fatigue, increased mood disturbance and decreased exercise performance can result. This is commonly known as overreaching and if increased training and limited recovery is continued, it is believed that the more serious state of overtraining may develop. This is relatively commonly experienced in athletes, however little scientific investigation has been conducted to determine the characteristics and underlying mechanisms. The overall aim of this thesis was to gain a greater understanding of the state of overreaching and to specifically provide new information on potential markers of this state as well as possible mechanisms. To study the cumulative effects of exercise stress and subsequent recovery on performance changes, fatigue indicators and possible mechanisms, the training of endurance cyclists was systematically controlled and monitored in two separate investigations. A number of variables were assessed including performance, physiological, biochemical, psychological, immunological and hormonal variables. In addition heart rate variability and serotonergic responsiveness were also assessed. Some of the more pertinent effects of overreaching included an increase in heart rate variability, a reduction in carbohydrate oxidation, an increase in serotonergic responsiveness and a reduction in stress hormone concentrations. These results suggest that autonomic imbalance in combination with decreased hormonal release appears to be related to the decline in performance and elevated fatigue apparent in overreached athletes. Additionally it also appears that alterations in the hypothalamic-pituitary adrenal axis may occur in overreached athletes.
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Kido, Larissa Akemi 1988. "Terapias antiangiogênicas, uso de Finasterida e resposta hormonal na próstata de camundongos senis". [s.n.], 2013. http://repositorio.unicamp.br/jspui/handle/REPOSIP/318025.
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Orientador: Valéria Helena Alves Cagnon QuiteteDissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-23T04:47:08Z (GMT). No. of bitstreams: 1 Kido_LarissaAkemi_M.pdf: 14026607 bytes, checksum: 4b5dcdcd04b3cf312f7b62cb4cf2ac2b (MD5) Previous issue date: 2013
Resumo: A senescência está associada a mudanças significativas no ambiente hormonal, sendo fator causador de alterações morfofuncionais na próstata. Os diferentes processos biológicos que ocorrem na próstata são regulados por polipeptídeos, dentre esses os fatores de crescimento do endotélio vascular (VEGF) e Endostatina, relacionados à angiogênese. Além disso, inibidores da enzima 5_ redutase-II, como a finasterida, tem papel importante no combate às doenças prostáticas. Assim, os principais objetivos desse estudo foram avaliar os efeitos estruturais e moleculares das terapias antiangiogênicas e da finasterida sobre a próstata ventral de camundongos durante a senescência. Noventa camundongos machos FVB de 18 e 52 semanas de idade foram divididos nos seguintes grupos: Jovem (JV) e Senil (SEN), os quais receberam injeções de Solução Fisiológica 0,9% (5 mL/Kg/dia s.c.); Finasterida (FIN): injeções de Finasterida (20 mg/Kg, s.c.); SU5416 (SU): SU5416 (6 mg/Kg, i.p.); TNP-470 (TNP): injeções de TNP-470 (15 mg/Kg, s.c.), e SU5416 + TNP-470 (SU+TNP): os mesmos tratamentos dos grupos SU e TNP. Após 21 dias de tratamento, amostras do lobo ventral da próstata foram coletadas e submetidas às análises morfológicas, imunohistoquímicas e Western Blotting. Os resultados demonstraram alterações moleculares e estruturais no microambiente prostático durante a senescência, como atrofia presença de células inflamatórias, e lesões proliferativas, as quais foram interrompidas e ou bloqueadas através dos tratamentos com as drogas antiangiogênicas e pela finasterida. Os resultados moleculares revelaram no grupo senil a diminuição das reatividades para AR e Endostatina, e aumento para ER-_, ER-_ e VEGF, quando comparados aos camundongos jovens. Os camundongos dos grupos tratados com finasterida, SU5416 e SU5416+TNP-470, quando comparados aos do grupo senil, demonstraram de forma geral diminuição das reatividades de VEGF e ER-_ e aumento de ER-_. Já o tratamento com TNP-470 foi marcado principalmente pela redução da reatividade e dos níveis protéicos de AR e ER-_, quando comparado aos grupos jovem e senil. Desta maneira, conclui-se que a senescência favoreceu a ocorrência de alterações estruturais e/ ou funcionais que sugerem o aparecimento de lesões malignas, em virtude do desequilíbrio na sinalização entre epitélio e estroma. O tratamento com finasterida, SU5416 e SU5416+TNP- 470 mostraram-se mais ativos na regulação dos processos proliferativos através da via estrogênica
Abstract: Senescence is associated with significant changes in the hormonal environment and is a cause of morphological and functional changes in the prostate. The different biological processes that occur in the prostate are influenced by different factors such as vascular endothelial growth factor (VEGF) and Endostatin, related to angiogenesis. Also, 5_-reductase inhibitors, such as finasteride, play an important role in treatment of prostatic diseases. Thus, the aims of this study were to evaluate the structural and molecular effects of antiangiogenic therapies and finasteride on the ventral prostate of mice during senescence. Ninety 52 and 18 week old male FVB mice, were divided into groups: Young (YNG) and Senile (SEN) groups, which received 0.9% saline (5 mL/kg/day sc) injections; Finasteride (FIN) group: Finasteride (20 mg/kg, sc); SU5416 (SU) group: SU5416 (6 mg/kg, ip) injections; TNP-470 (TNP) group: TNP-470 (15 mg/kg, sc) injections and SU5416+TNP-470 (SU+TNP470) group: The same treatment as the SU and TNP-470 groups. After 21 days of treatment, samples of the ventral lobe of the prostate were collected and analyzed for morphological, immunohistochemical and Western Blotting analyses. The results demonstrated structural and molecular changes in the prostatic microenvironment during senescence, such as atrophy, inflammatory cells, and proliferative lesions, which were interrupted and/or blocked by treatment with antiangiogenic drugs and finasteride. The molecular results revealed decreased reactivity for AR and Endostatin, and an increase for ER-_, ER-_ and VEGF in the senile group, when compared to young mice. The mice in the groups treated with finasteride, SU5416 and SU5416 + TNP-470, when compared to the senile group, showed in general decreased VEGF and ER-_ reactivities and increased ER-_ reactivity. The treatment with TNP-470 however, was marked mainly by reduced AR and ER-_ reactivity and protein levels, when compared to young and senile groups. Thus, it can be concluded that senescence contributed to the occurrence of structural and/or molecular alterations that suggest the onset of malignant lesions, due to the imbalance in the signaling between the epithelium and stroma. Treatments with finasteride, SU5416 and SU5416+TNP-470, were active in the regulation of proliferative processes by means of the estrogen pathways
Mestrado
Anatomia
Mestra em Biologia Celular e Estrutural
44
Villar, David. "Hormonal regulation of the fibre growth and moult cycle in cashmere goats". Thesis, University of Aberdeen, 1998. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU106170.
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The role of selected hormones in the control of hair follicle activity, fibre growth and moult in cashmere goats was investigated by manipulation of prolactin (PRL), thyroid hormones, and growth hormone (GH) individually or in combination. In experiment 1, the effect of different doses of the anti-thyroid drug "propylthiouracil" (PTU), on thyroxine (T4) and triiodothyronine (T3) profiles and deiodinase enzyme activities in liver, kidney and skin tissues was determined. Types II and III deiodinase enzymes were found to be present in goat skin but not type I. It was concluded that the supply of T3 within the skin was partly independent of circulating hormone profiles. In experiment 2, goats were treated with PTU, triiodothyronine (T3) and bromocriptine (Br) to decrease T3 availability to tissues and circulating PRL concentrations, respectively. Treatment with Br delayed the spring rise in plasma PRL concentrations (P=0.06) and primary (P<0.05) hair follicle activity, and delayed moult onset (P<0.01). PTU treatment did not significantly affect hair follicle activity but generally delayed the time of moult onset (P<0.05). The effects of the treatments were not additive, indicating that the actions of the two hormones were not independent. The effects of PTU and Br treatments were not exerted through changes in IGF-I binding activity in the skin, but binding was greater (P<0.01) in April than November. In experiment 3, treatment with bovine somatotropin (bST), T4 or metoclopramide to increase circulating concentrations of GH, T4 or PRL, failed to prolong the period of anagen in hair follicles, but bST increased fibre growth rate (P<0.05) and this was associated with higher circulating IGF-I concentrations. It is concluded that manipulation of the cycle of the cashmere-producing hair follicle is unlikely to be achieved through manipulation of circulating hormone concentrations alone and that much regulation of hair follicle activity occurs within the skin itself, possibly through changes in enzymes that control the supply of T3 to the follicles, in hormone receptor activity, and in the rate of synthesis of IGF-I and other growth factors within the skin.
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Maciel, Luciana França Smith. "Expressão dos receptores endometriais de estrógeno e progesterona em éguas acíclicas após administração de progesterona". Botucatu, 2017. http://hdl.handle.net/11449/151275.
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Orientador: Cezinande de MeiraResumo: Progesterone (P4) is frequently used after the administration of estradiol, to prepare seasonal non-cyclic mares as embryo recipients, however previous studies have reported gestation of seasonal non-cyclic mares treated only with P4. The objective of the present study was to evaluate the gene and protein expression of estrogen receptor alpha (ERα), estrogen beta (ERβ) and progesterone (PR) in the endometrium of seasonal non-cyclic mares treated with long acting progesterone (LAP4). Eight mares were used during the seasonal anoestrus phase, uterine biopsies were performed immediately before and five days after administration of 1,5 g of LA P4. Blood samples were taken daily for the determination of plasma P4 concentration. The protein expression of the receptors was evaluated by the immunohistochemistry and the immunostaining area percentage was determined by the ImageJ software. Transcripts abundance for ERα (ESR1), ERβ (ESR2) and PR (PGR) were determined by RT-qPCR. ERα showed higher protein expression (p <0.05) after administration of P4LA, but there was no change in mRNA abundance encoding this gene (p> 0,05). Tendency to lower protein expression was observed (p=0,07) and gene expression inhibition (p <0,05) for ERβ, PR did not changes (p>0,05). The plasma concentration of P4 presented a higher concentration 24 hours after the application of LA P4 (D1), with subsequent decline in these values (p<0,05). The 1.5 g dose of LA P4 reached the minimum concentrations of P4 requi... (Resumo completo, clicar acesso eletrônico abaixo)
Mestre
46
Mohammad, Helai P. "CHARACTERIZATION OF THE HORMONAL REQUIREMENTS AND MOLECULAR MECHANISMS THAT UNDERLIE PITUITARY TUMORIGENESIS IN MICE OVEREXPRESSING LUTEINIZING HORMONE". Case Western Reserve University School of Graduate Studies / OhioLINK, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=case1080073606.
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Scarano, Wellerson Rodrigo. "Repercussões histopatologicas na prostata ventral do gerbilo da Mongolia (Merinones unguiculatus) apos suplementação por hormonios esteroides". [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317918.
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Orientador: Sebastião Roberto TabogaTese (doutorado) - Universidade Estadual de Campinas, Instituto de Biologia
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Resumo: O tecido prostático é susceptível aos desníveis hormonais provocados, principalmente pelo processo de envelhecimento. A hiperplasia benigna prostática e o câncer de próstata são doenças que acometem uma grande parcela da população masculina, e parecem estar envolvidas com alterações hormonais. Por isso, o esclarecimento dos processos celulares e teciduais envolvendo os hormônios sexuais: testosterona e estradiol são, sem dúvida, importantes para o entendimento da etiologia desses processos patológicos. O gerbilo (Meriones unguiculatus) foi utilizado como modelo experimental pois, segundo a literatura, é susceptível ao aparecimento de lesões autóctones e responde bem à carcinogênese experimental, mostrando-se um bom modelo experimental. Numa primeira etapa, foram utilizados animais de três idades diferentes: púbere, adulta e senil. Esses animais foram submetidos à suplementação androgênica e as próstatas ventrais foram destinadas a análises histopatológicas, quantitativas, imunocitoquímicas e ultraestruturais. Foi observado aumento no peso da glândula e também na altura das células epiteliais em todas as idades. Tal aumento reflete o aumento da capacidade sintética observada pela dilatação das organelas de síntese, às vezes de aspecto vesiculoso, ocupando toda a região supranuclear. Nos animais adultos e velhos foram notadas regiões hiperplásicas e displásicas freqüentemente associadas a Neoplasias Intraepiteliais de diferentes graus e a adenocarcinomas. Houve aumento na espessura da camada de células musculares lisas (CML) ao redor dos ácinos nos animais púberes e adultos, enquanto nos animais velhos houve diminuição dessa camada. Além disso, as CML se mostraram aparentemente hipertróficas e com maior atividade sintética nos animais púberes e adultos. Foi notado aparente aumento da vascularização periacinar, onde se observou a presença de freqüentes vasos sanguíneos em todas as idades após o tratamento. Ademais, em todas as idades foi observado aumento da densidade de marcação de receptores androgênicos após o tratamento, evidenciando a possível relação desses receptores com os efeitos observados. Em uma segunda etapa experimental, avaliou-se o efeito do estradiol sobre o tecido prostático intacto e hipoandrogênico em animais adultos, tentando com isso simular situações de descompensação hormonal, típicas da senilidade. As alterações epiteliais foram freqüentes nos animais tratados com estradiol onde se observou aumento na altura das células epiteliais, aparecimento de regiões de intensa displasia e hiperplasia, e a formação de PINs. Outro aspecto que independe da presença da testosterona é o arranjo dos elementos fibrilares e não fibrilares da matriz extracelular entre as CML, apontando para um possível papel dessas células no rearranjo e na síntese desses componentes após os tratamentos estrogênicos. Nos animais castrados observou-se acúmulo de elementos da matriz extracelular sob o epitélio e em animais intactos presença desses elementos dispersos e escassos. Em ambos os grupos: intactos e castrados, notou-se que as CML e os fibroblastos apresentam fenótipo secretor acentuado após o tratamento com estradiol. Houve aumento na densidade de marcação ERa e AR positivos em regiões de hiperplasia apontando para um possível papel desses receptores na formação de lesões pré-malígnas e malignas. Portando, conclui-se que o gerbilo é susceptível a ação da testosterona e do estradiol, os quais provocam desarranjos estruturais e ultraestruturais de cunho patológico e funcional, mostrando-se um ótimo modelo para o estudo das doenças prostáticas de etiologia hormonal
Abstract: Not informed.
Doutorado
Biologia Celular
Doutor em Biologia Celular e Estrutural
48
Welsh, Shayne. "Hormonal control of wood formation in radiata pine". Thesis, University of Canterbury. Biological Sciences, 2006. http://hdl.handle.net/10092/968.
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Pinus radiata is by far the dominant species grown in New Zealand plantations as a renewable source of wood. Several wood quality issues have been identified in the material produced, including the high incidence of compression wood, which is undesirable for end users. At present our understanding of the complex array of developmental processes involved in wood formation (which has a direct bearing on wood quality) is limited. Hence, the forest industry is interested in attaining a better understanding of the processes involved. Towards this goal, and for reasons of biological curiosity, the experiments described in this thesis were carried out to investigate several aspects of xylem cell development. In an in arbor study, changes in the orientation of cortical microtubules and cellulose microfibrils were observed in developing tracheids. Results obtained provide evidence that cortical microtubules act to guide cellulose synthase complexes during secondary wall formation in tracheids. The mechanisms involved in controlling cell wall deposition in wood cells are poorly understood, and are difficult to study, especially in arbor. A major part of this thesis involved the development of an in vitro method for culturing radiata pine wood in which hormone levels, nutrients, sugars and other factors, could be controlled without confounding influences from other parts of the tree. The method developed was used in subsequent parts of this thesis to study compression wood development, and the influence of the hormone gibberellin on cellulose microfibril organisation in the cell wall. Results from the in vitro compression wood experiments suggested that: 1. when a tree is growing at a lean, the developing cell wall was able to perceive compressive forces generated by the weight of the rest of the tree, rather than perceive the lean per se. 2. ethylene, rather than auxin, was involved in the induction of compression wood. Culture of stem explants with gibberellin resulted in wider cells, with steeper cortical microtubules, and correspondingly steeper cellulose microfibrils in the S2 layer of developing wood cells. This observation provides further evidence that the orientation of microtubules guides the orientation of cellulose microfibrils. Overall, the work described in this thesis furthers our knowledge in the field of xylem cell development. The stem culture protocol developed will undoubtedly provide a valuable tool for future studies to be carried out.
49
Renlund, Nina. "Hormonal and paracrine influences on Leydig cell steroidogenesis /". Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-842-8/.
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Schoneveld, Jan Leonard Martin. "The hormonal regulation of carbamoylphosphate synthetase I expression". [S.l. : Amsterdam : s.n.] ; Universiteit van Amsterdam [Host], 2004. http://dare.uva.nl/document/76536.
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