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Talken, Beth L. "Assembly of the Lw¹⁶ and Ld class I MHC molecules". free to MU campus, to others for purchase, 1996. http://wwwlib.umi.com/cr/mo/fullcit?p9720532.
Pełny tekst źródłaPang, Ha Sang. "Identification of CD8+ T cell epitopes from HCA661 presented by HLA-A2 molecules /". View abstract or full-text, 2006. http://library.ust.hk/cgi/db/thesis.pl?BIOL%202006%20PANG.
Pełny tekst źródła葉德俊 i Tak-chun Timothy Yip. "Characterization of a monoclonal antibody reactive against major histocompatibility complex class II antigens". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1992. http://hub.hku.hk/bib/B3123334X.
Pełny tekst źródłaYip, Tak-chun Timothy. "Characterization of a monoclonal antibody reactive against major histocompatibility complex class II antigens /". [Hong Kong] : University of Hong Kong, 1992. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13478771.
Pełny tekst źródłaHume, Clifford Robert. "Regulation of HLA class II expression in class II negative mutant B-cell lines /". Access full-text from WCMC, 1989. http://proquest.umi.com/pqdweb?did=745028251&sid=1&Fmt=2&clientId=8424&RQT=309&VName=PQD.
Pełny tekst źródłaHalley, Lorna Louise. "The investigation of the HLA system and wheat gluten in determining risk of schizophrenia". Thesis, University of the Highlands and Islands, 2015. https://pure.uhi.ac.uk/portal/en/studentthesis/the-investigation-of-the-hla-system-and-wheat-gluten-in-determining-risk-of-schizophrenia(60acd449-c659-4743-9dbd-4392c0fc015a).html.
Pełny tekst źródłaKosmoliaptsis, Vasilis. "Investigation into the immunogenicity of human leukocyte antigen mismatches in kidney transplantation". Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609630.
Pełny tekst źródłaSchulte, Kathleen Q. "Mutagenized HLA DNA Constructs: Tools for Validating Molecular HLA Typing Methodologies". Thesis, University of North Texas, 1999. https://digital.library.unt.edu/ark:/67531/metadc500888/.
Pełny tekst źródłaYamamoto, Masaru. "Synthesis and oxidation studies of sulfur containing inhibitors for human leukocyte elastase : (2) synthesis of cyclic peptide analogs for tissue factor pathway inhibitor (TFPI) : Part 2 synthesis and evaluation of aziridinecarboxylic acid analogs as a new family of cysteine proteinase inhibitors". Diss., Georgia Institute of Technology, 1993. http://hdl.handle.net/1853/25953.
Pełny tekst źródłaChang, Yea-wen. "Application of molecular genetic techniques to the study of major histocompatibility complex class II allelic associations with insulin-dependent diabetes mellitus in Chinese /". Hong Kong : University of Hong Kong, 1997. http://sunzi.lib.hku.hk/hkuto/record.jsp?B18539919.
Pełny tekst źródłaOudshoorn, Machteld. "Investigations into the complexity and polymorphism of HLA-D loci in South Africa". Doctoral thesis, University of Cape Town, 1989. http://hdl.handle.net/11427/26581.
Pełny tekst źródłaBonfiglioli, Rubens. "Frequência dos alelos do HLA-B27 em pacientes brasileiroa com artrite psoriásica". [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310633.
Pełny tekst źródłaTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
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Resumo: Este estudo prospectivo analisou a epidemiologia, clínica e perfil genético de 102 pacientes brasileiros com Artrite Psoriásica. A associação do complexo maior de histocompatibilidade (MHC) de classe I, e os alelos do HLA-B27 com aquelas variáveis foram avaliados e comparados com sadios controles, HLA-B27 positivos, compondo um grupo de 111 indivíduos. A predominância foi do sexo masculino (59,8%), raça caucasóide (89,2%) e HLA-B27 negativos (79,4%). Oligoartrite assimétrica (62,7%) foi o subgrupo de Artrite Psoriásica mais observado, seguido pela forma espondilítica (16,7%) e poliarticular (15,7%). O sexo masculino e o subgrupo dos espondilíticos foram estatisticamente mais associados ao HLA-B27, e o subgrupo oligoarticular ao HLA-B27 negativo. Entre os 21 pacientes com Artrite Psoriásica e HLA-B27 positivos existiu uma significante prevalência do HLA-B*2705 (90,5%), similar ao observado no grupo controle (80,2%); HLA-B*2703 e HLA-B*2707 foram estatisticamente associados ao grupo controle
Abstract: This prospective study analyzed the epidemiologic, clinical and genetic profile of 102 Brazilian patients with psoriatic arthritis (PsA). The association of the major histocompatibility complex (MHC) class I and the HLA-B27 alleles with these variants was outlined, and compared to a control healthy HLA-B27 positive group of 111 individuals. There was a predominance of male gender (59.8%), Caucasian race (89.2%) and negative HLA-B27 (79.4%) patients. Asymmetric oligoarthritis (62.7%) was the most frequently observed clinical PsA subgroup, followed by spondylitis (16.7%) and polyarthritis (15.7%). Male gender and the spondylitis subgroup were statistically associated to the positive HLAB27 and the oligoarthritis subgroup was associated to the negative HLA-B27. Among the 21 HLA-B27 positive PsA patients, there was a significant prevalence of the HLA-B*2705 allele (90.5 %), similar to that observed in the control group (80.2%); HLA-B*2703 and HLA-B*2707 were statistically associated to the control group. Other antigens such as HLA- B07 (14 patients), HLA-B08 (14 patients) and HLA-B44 (13 patients) among others, were found in HLA-B27-negative patients
Doutorado
Clinica Medica
Doutor em Clínica Médica
Odeberg, Jenny. "Human cytomegalovirus immune evasion strategies /". Stockholm, 2002. http://diss.kib.ki.se/2002/91-7349-126-8.
Pełny tekst źródłaPatel, Kantibhai Motiram. "The association of the human leukocyte antigens alleles and type 2 diabetes mellitus among Mexican Americans". To access this resource online via ProQuest Dissertations and Theses @ UTEP, 2009. http://0-proquest.umi.com.lib.utep.edu/login?COPT=REJTPTU0YmImSU5UPTAmVkVSPTI=&clientId=2515.
Pełny tekst źródłaWong, Hoi-hei Vera, i 王愷曦. "Isolation of human leukocyte antigen G/cytokeratin 7 positive fetal cells from transcervical samples for potential use in prenatal genetic diagnosis". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2015. http://hdl.handle.net/10722/208587.
Pełny tekst źródłapublished_or_final_version
Obstetrics and Gynaecology
Master
Master of Philosophy
Rodrigues, N. R. "The human cytochrome P-450 21-hydroxylase genes". Thesis, University of Oxford, 1987. http://ora.ox.ac.uk/objects/uuid:77be8950-4675-4a55-ab4f-27b788082007.
Pełny tekst źródłaSchaffer, Marie. "HLA and KIR gene polymorphism in hematopoietic stem cell transplantation /". Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-836-3/.
Pełny tekst źródłaChiu, Angela Chen-Yen. "DNA Typing of HLA-B by PCR with Primer Mixes Utilizing Sequence-Specific Primers". Thesis, University of North Texas, 1997. https://digital.library.unt.edu/ark:/67531/metadc278947/.
Pełny tekst źródłaMaruya, Etsuko. "Evidence that CD31, CD49b, and CD62L are immunodominant minor histocompatibility antigens in HLA identical sibling bone marrow transplants". Kyoto University, 2001. http://hdl.handle.net/2433/150586.
Pełny tekst źródłaBraga, Mayara Perez. "Alorreatividade dos enxertos ósseos homólogos na reconstrução alveolar em humanos". Universidade do Estado do Rio de Janeiro, 2014. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=8418.
Pełny tekst źródłaBone allografts are used without HLA donor-receptor compatibility or imunosupressor therapy. Taking in consideration the amount of bone graft procedures performed in Brazil and the possible deleterious effect of HLA sensitization in solid organ transplantation, the aim of this study was to evaluate fresh-freeze bone graft alorreactivity used in ridge augmentation surgery before oral rehabilitation with implants supported bridges. Anti-HLA and anti-MICA antibodies were evaluated by Labscreen Mixed test, at 0, 7, 30, 90 e 180 days after bone transplantation in 15 patients (6 men e 9 women, mean age 58,1, SD=10,1) treated at the Dental Institute of the Rio de Janeiro Catholic University. If the mixed test (Normalized Background Ratio, NBG>4,5) was positive, donor specificity was evaluated by Labscreen Single test (Single Antigen Bead Assay technology, SABA). None of patients had previous transplant history, 4 had transfusion history, and all women had pregnancy history. Ten patients did not have positive results at baseline and were considered not sensitized previously; 6 patients of them did not have any sensitization evidence during 6 month follow up, 2 patients had positive reaction for anti-HLA Class I and II; 2 were positive for anti-HLA Class I only; e 2 patients were positive for anti-MICA, and were considered sensitized by oral bone graft. Two patients had increased values of Median Fluorescence Intensity (ΔMFI>1000) of anti-HLA donor specific antibodies Class I and II, 2 for Class II only, showing a donor specific alorreactivity. The results sugest an oscilatory HLA reactivity, confirmed by the donor specific antibodies formation on 4 patients (27%) of this study.
Pecora, Rafael Antonio Arruda. "Associações dos anticorpos anti-HLA pré-formados e da compatibilidade HLA à rejeição celular aguda precoce no transplante hepático". Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/5/5168/tde-09082016-154954/.
Pełny tekst źródłaINTRODUCTION: Human leucocyte antigens (HLA) molecules are the main targets of rejection in solid organ transplantation. Significance of anti-HLA preformed antibodies and HLA compatibility remains unclear in liver transplantation. Majority of liver transplants are performed without assessment of preformed anti-HLA antibodies and HLA-matching. OBJECTIVES: Evaluate associations of preformed anti-HLA antibodies and HLA compatibility with acute cellular rejection (ACR) in the first 90 days after transplantation. METHODS: Prospective cohort of ABO-identical/compatible liver transplants between January 2012 and December 2013. Grafts that survived more than 4 days were included. Anti-HLA class I and II antibodies were determined by solid phase assays (LABScreen® Mixed and LABScreen® ingle Antigen). A mean fluores en e intensity ( I) >= 1.000 was considered as positive for anti-HLA antibodies. Recipients and donors HLA typing for HLA-A, B and DR were performed using polymerase chain reaction (PCR) assays. According to HLA mismatches (MM), transplants were divided in compatible (0-3 MM) and incompatible (4-6 MM). Only biopsy proven ACR episodes, associated with abnormal liver tests, were considered. Banff criteria was used for diagnosis of ACR and episodes were graded as mild, moderate and severe. Cox proportional hazards models were performed and associated hazard ratios (HR) were determined. Free ACR rates were estimated with Kaplan-Meier analysis and were compared between groups with the log-tank test. RESULTS: One hundred twenty nine transplants were analyzed. Overall incidence of ACR was 14.7% in 90 days. Assessment of anti-HLA pre-formed antibodies was considered positive in 35.6% of transplants. Regarding HLA compatibility, 91.5% were considered incompatible. Anti-HLA antibodies sensitization was associated with an increased risk of ACR (HR= 4.3; CI 95%=1,3 - 13,5; p=0.012). According to class of antibody, we could observe that class II was associated with an increased risk of ACR (HR=56.4; CI 95%= 4.5 - 709.6; p=0.002). Class I antibodies were considered tendency to increased risk of ACR (HR=2.7; CI 95%= 0.8 - 8.8; p=0,08). A better HLA compatibility was not associated with a lower risk of ACR (HR=0.9; CI 95%=0.2-3.8 p=0.89). CONCLUSIONS: The present study indicates that preformed anti-HLA antibodies with I >= 1.000 are associated with an increased risk of early ACR rejection in liver transplantation. Class II antibodies were also associated with an increased risk of ACR. Class I antibodies were considered tendency. HLA matching had no influence on early acute cellular rejection on this study. Anti-HLA antibodies sensitization could serve as a marker of increased immunoreactivity to the graft. It would serve for tailored immunosuppression
Pina, Fabiana Pompeo de. "Artrite reumatoide em Afro-brasileiros : "O papel do HLA"". [s.n.], 2009. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310626.
Pełny tekst źródłaDissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas
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Resumo: A associação de antígenos de histocompatibilidade com a Artrite Reumatóide (AR) vem sendo demonstrada em inúmeros estudos. No entanto, a avaliação em populações afro-descendentes ainda foi pouco estudada. Os propósitos deste estudo foram os de determinar a freqüência dos alelos HLA-DRB1 e as contribuições do polimorfismo desses alelos na susceptibilidade da AR na população afrobrasileira. Este estudo avaliou também, se a teoria do epitopo semelhante (SE) e o modelo de proteção da Artrite Reumatóide (RAP Model) se aplicam aos pacientes afro-brasileiros com AR. Os alelos HLA-DRB1 de 72 pacientes afro-brasileiros com AR, diagnosticados pelos critérios do American College of Rheumatology (ACR), e de 75 indivíduos saudáveis foram tipados e subtipados utilizando-se a técnica de reação em cadeia de polimerase de DNA amplificado hibridizado, com seqüência de primers específicos de alta e baixa resolução, e depois comparados. Os alelos HLADRB1 *0404 e *0405 apresentaram freqüência maior nos pacientes do que no grupo controle. Já, alelo HLA-DRB1*0102 apresentou uma freqüência aumentada no grupo controle (9,3%), quando comparada com a freqüência nos pacientes. Os alelos DRB1 considerados como pertencentes ao grupo do epitopo semelhante estavam presentes em 39 pacientes (54,2%) e em 20 controles (26,7%), indicando que teoria do epitopo semelhante se aplica à população afro-brasileira com Artrite Reumatóide. Os alelos HLA-DRB1 que apresentavam a sequência DERAA (alelos protetores) reduziram, de forma independente, o risco de desenvolver AR. Os dados obtidos apontam para uma intensa miscigenação racial presente no Brasil. Assim, como nos faz concluir que a susceptibilidade da Artrite Reumatóide em afro-brasileiros é, provavelmente, mediada pela interação de fatores genéticos e étnicos
Abstract: The association of histocompatibility antigens with Rheumatoid Arthritis (RA) comes being demonstrated in innumerable studies. However, the evaluation in afrodescendents populations still little was studied. The aim of this study has been to determine the frequency of HLA-DRB1 alleles, and the contributions of the polymorphism of these alleles in the susceptibility of RA in the Afro-Brazilian population as well. This study, also evaluated, if the theory of the shared epitope (SE) and the model of protection of the Rheumatoid Arthritis (RAP Model) can also be applied to the Afro-Brazilian patients suffering RA. The HLA-DRB1 alleles in 72 Afro-Brazilian patients suffering RA, diagnosed in accordance to the criteria of the American College of Rheumatology (ACR), and of 75 healthful volunteers had been typed and sub-typed using the technique of the polymerase chain reaction of the amplified hybridized DNA, with specific sequence of primers of high and low resolution, were then compared. The HLA-DRB1 *0404 and *0405 alleles had presented higher frequency in the patients group than in the control group. The HLADRB1 *0102 alleles presented a frequency increased (9,3%) in the control group, when compared with the patients group. The DRB1 alleles considered as pertaining to the group of shared epitope were present in 39 patients (54.2%) and in 20 members of the control group(26.7%), indicating that the theory of the shared epitope it is also applied to the Afro-Brazilian population with Rheumatoid Arthritis. The HLADRB1 alleles that presented DERAA sequence (protectors alleles), had reduced, of independent form, the risk to develop RA. The gotten data point to an intense racial miscegenation in Brazil. Thus, as in it makes them to conclude that the susceptibility of the Rheumatic Arthritis in Afro-Brazilian is, probably, determined by the interaction of genetic and ethnic factors
Mestrado
Clinica Medica
Mestre em Clinica Medica
Yin, Liusong. "Studies of HLA-DM in Antigen Presentation and CD4+ T Cell Epitope Selection: A Dissertation". eScholarship@UMMS, 2014. http://escholarship.umassmed.edu/gsbs_diss/700.
Pełny tekst źródłaScott, Carol Elizabeth DeWeese. "Molecular modeling and experimental characterization of HLA-DQ proteins and protein/peptide complexes : correlation with insulin-dependent diabetes mellitus (IDDM) /". Thesis, Connect to this title online; UW restricted, 1997. http://hdl.handle.net/1773/8089.
Pełny tekst źródłaWavamunno, Moses Dennis. "The role of pre-transplant antibodies in predicting chronic renal allograft injury". Thesis, The University of Sydney, 2009. https://hdl.handle.net/2123/28207.
Pełny tekst źródłaLemy, Anne. "Do MICA antibodies impact on renal graft outcomes?" Doctoral thesis, Universite Libre de Bruxelles, 2012. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209617.
Pełny tekst źródłaNéanmoins, l’accès à la transplantation est limité par la pénurie d’organes et dans certains cas, par la présence d’anticorps anti-HLA avant la greffe.
Bien que la présence d’anticorps anti-HLA spécifiques du donneur avant ou après la greffe ait été associée au rejet aigu et à la perte chronique d’allogreffe, un rejet humoral tant aigu que chronique peut survenir sans que ces anticorps soient détectables dans le sérum, suggérant que des réponses autologues ou allo-immunes contre des antigènes dits « mineurs » pourraient jouer un rôle dans le rejet et la perte de greffe.
MICA, en raison de son polymorphisme important, est considéré aujourd’hui comme un des systèmes antigéniques mineurs les plus robustes par sa capacité à induire des allo-anticorps. Cependant, un effet pathogène des anticorps anti-MICA sur le greffon rénal demeure à ce jour, non formellement établi.
Le but de la présente recherche a été d’étudier l’épidémiologie des anticorps anti-MICA à partir d’une large cohorte de volontaires sains et de patients atteints d’insuffisance rénale chronique terminale, de déterminer les facteurs de risque d’immunisation contre MICA, de spécifier la nature autologue ou allogénique de ces anticorps et d’évaluer au sein des patients ultérieurement transplantés, l’impact de ces anticorps sur le rejet et la survie de greffe.
La méthode utilisée pour l’identification des anticorps anti-MICA est la technique Luminex, consistant à faire réagir du sérum avec des billes de polystyrène tapissées par un seul antigène MICA recombinant, l’intensité de la liaison antigène-anticorps étant révélée par un fluorocytomètre suite à l’adjonction d’un second anticorps anti-IgG couplé à une substance fluorescente.
Nous avons identifié la grossesse, les transfusions sanguines, la greffe préalable et également l’urémie comme étant des facteurs de risque indépendants d’immunisation contre MICA.
Nous n’avons pas observé d’effet délétère des anticorps anti-MICA sur la survie à long terme du greffon rénal alors que les anticorps anti-MICA ont été plus fréquents chez les patients dits «à haut risque immunologique» et en particulier chez les patients immunisés contre le HLA.
Nos résultats suggèrent que plutôt d’être pathogènes, les anticorps anti-MICA pourraient être simplement des marqueurs de haut risque immunologique. Ceci remet donc en question l’utilité d’un monitoring des anticorps anti-MICA par la technologie Luminex.
Renal transplantation represents the treatment of choice of stage V chronic kidney disease by offering a longer life expectancy and a better quality of life than dialysis. Nevertheless, the access to transplantation is limited by the shortage of organs and, in some cases, by the presence of HLA antibodies before transplantation.
While the presence of either preformed or post-transplant donor specific anti-HLA antibodies has been associated with acute rejection or chronic graft loss, acute or chronic antibody-mediated injury may also occur in the absence of detectable anti-HLA antibodies, suggesting that autologuous or allo-immune response to other relevant minor or non-HLA antigenic determinants might play a role in rejection and subsequent graft loss. Especially, MHC class I-related chain A (MICA), a highly polymorphic minor antigenic system, is now considered to be the most robust minor antigenic system capable of inducing allo-antibodies. However, the possible deleterious effect of MICA antibodies has not been formerly established yet.
The goal of the following work was to determine the risk factors for MICA sensitization, to specify the autologuous or allogeneic nature of MICA antibodies and to assess the impact of preformed and 1 yr post-transplant MICA antibodies on defined renal graft outcomes in large cohorts of patients. The method employed for the identification of MICA antibodies was a Luminex single antigen beads assay. We found that pregnancy, previous blood transfusion, previous graft as well as chronic kidney disease were independent risk factors for MICA sensitization.
Even if we had found a higher frequency of MICA antibodies in patients at higher immunological risk and especially, MICA antibodies had been closely associated with HLA sensitization, we showed a lack of a deleterious effect of MICA antibodies on long-term renal graft outcomes.
Our findings suggest that MICA antibodies are merely surrogate markers of high immunological risk and really question the monitoring of MICA antibodies by the presently available MICA single antigen flow beads assays.
Doctorat en Sciences médicales
info:eu-repo/semantics/nonPublished
Chang, Yea-wen, i 張雅雯. "Application of molecular genetic techniques to the study of major histocompatibility complex class II allelic associations with insulin-dependent diabetes mellitus in Chinese". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1997. http://hub.hku.hk/bib/B31213960.
Pełny tekst źródłaFelício, Leandro Prado. "Variabilidade e história evolutiva do gene HLA-E". Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/3597.
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Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
The HLA-E locus is a Human Major Histocompatibility Complex (MHC) gene associated with immune-modulation and suppression of the immune response by the interaction with specific NK and T cell receptors. The HLA-E gene is considered the most conserved locus in the human HLA; however, this low variability might be a consequence of the scarce number of studies focusing this subject. In this mastering thesis we assessed the HLA-E coding and 3’ untranslated region variability in a group of individuals from Brazil and the results were evaluated together with data from the 1000Genomes Consortium. Altogether, only 28 variation sites were found in approximately 2724 bp evaluated. These variation sites were arranged into 33 haplotypes, most of them (98.2%) encoding one of the two HLA-E molecules found worldwide, i.e., the molecules associated with the allele groups E*01:01 and E*01:03. Interestingly, 85% of all haplotypes were represented by only three different sequences, each of them associated with one of the main known HLA-E coding alleles, E*01:01:01, E*01:03:01 and E*01:03:02, all of them found worldwide. This phenomenon, together with the comparisons with other primate sequences, reveals that these two main allele groups (and molecules) arose early before human speciation, and indicates that E*01:03:01 might be the oldest allele. In addition, the low nucleotide diversity found for the HLA-E coding and 3’UTR in worldwide populations suggests that the HLA-E gene is in fact a conserved gene, which might be a consequence of its key role in the modulation of the immune system.
O loco HLA-E é um gene do Complexo Principal de Histocompatibilidade Humano (MHC), cujo produto está relacionado com a modulação e supressão da resposta imunitária por meio da interação com receptores específicos das células NK e linfócitos T. O gene HLA-E é considerado o loco menos polimórfico dos genes do complexo HLA, no entanto, esta baixa variabilidade pode ser uma consequência do pequeno número de estudos realizados sobre esse tema. No presente trabalho, a variabilidade das regiões codificadoras e 3’ não traduzida do gene HLA-E foi analisada em amostras brasileiras e os resultados foram comparados com dados obtidos pelo projeto 1000Genomes. Considerando todas as populações avaliadas, apenas 28 pontos de variação foram encontrados em uma região de aproximadamente 2724-pb. Estes pontos de variação estão arranjados em 33 haplótipos diferentes, a maioria deles (98%) codificando uma das duas moléculas HLA-E frequentemente encontradas, E*01:01 e E*01:03. Ainda, 85% dos haplótipos encontrados foram representados por apenas três sequências diferentes, cada uma deles associada a um dos principais alelos da região codificadora do gene HLA-E, E*01:01:01, E*01:03:01 e E*01:03:02. Todas essas sequências foram encontradas em todas as populações avaliadas. Este fenômeno, em conjunto com as comparações envolvendo sequências de primatas, sugere que estes dois grupos de alelos principais (e moléculas) surgiram antes da especiação e dispersão humana, além de indicar que o alelo E*01:03:01 pode ser o mais antigo dentre os demais. Ainda, a baixa diversidade nucleotídica encontrada para a região codificadora e 3' NT do gene HLA-E em populações de todo o mundo sugere que este gene é, de fato, bastante conservado, provavelmente devido ao seu papel chave na modulação das respostas imunes.
Foley, Bree Amanda. "The immunogenetics of natural killer cell alloreactivity". University of Western Australia. School of Pathology and Laboratory Medicine, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0242.
Pełny tekst źródłaYap, Cheng-Hon. "Factors influencing cryopreserved allograft heart valve degeneration". Connect to thesis, 2006. http://repository.unimelb.edu.au/10187/2120.
Pełny tekst źródłaAly, Theresa Ann. "Novel MHC analyses allow prediction of extreme genetic risk for type 1A diabetes /". Connect to full text via ProQuest. Limited to UCD Anschutz Medical Campus, 2007. http://proquest.umi.com/pqdweb?did=1400957021&sid=1&Fmt=6&clientId=18952&RQT=309&VName=PQD.
Pełny tekst źródłaTypescript. Includes bibliographical references (leaves 94-108). Free to UCD affiliates. Online version available via ProQuest Digital Dissertations;
Lie, Hanne Cathrine. "The role of genetic diversity in human sexual selection : is the MHC special?" University of Western Australia. School of Psychology, 2009. http://theses.library.uwa.edu.au/adt-WU2010.0053.
Pełny tekst źródłaGupta, Manu. "Autoimmune markers in autoimmune diabetes /". Stockholm, 2003. http://diss.kib.ki.se/2004/91-7349-756-8/.
Pełny tekst źródłaSantos, Kaisson Ernane dos. "Avaliação da história evolutiva do gene HLA-G por meio de polimorfismos de base única e da inserção AluyHG". Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tede/6686.
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The Major Histocompatibility Complex is mainly composed by genes of the adaptive immune response. In humans, part of this complex is known as the Human Leukocyte Antigens (HLA), whose genes are responsible for specific antigen presentation to effector immune cells. The classical class I HLA genes (HLA-A, -B and -C) are responsible for antigen presentation to T CD8+ cells and they constitute the most polymorphic genes in the human genome. This variability is maintained by selection mediated by microorganisms. In contrast to their classical counterparts, the non classical class I genes (HLA-G, -E and -F) present low variability and are associated with immune tolerance due to the interaction with NK and T cells inhibitor receptors. HLA-G is the most studied non classical gene, which is associated with immune response modulation, mainly during pregnancy. Considering that natural selection is acting on the HLA-G regulatory regions maintaining high heterozigosity in this region, we evaluated a nearby Alu insertion (AluyHG) correlating this Alu element with coding and 3’UTR HLA-G polymorphisms. The AluyHG insertion was particularly associated with the HLA-G haplotype known as G*01:01:01:01/UTR-1, considered a high-expressing HLA-G haplotype. The G*01:01:01:01/UTR-1/AluyHG haplotype would be the most recent HLA-G haplotypes, in spite of its high frequency in worldwide populations.
O Complexo Principal de Histocompatibilidade (MHC) é formado principalmente por genes que participam da resposta imunológica adaptativa. Entre esses genes encontramos o grupo denominado de Antígenos Leucocitários Humanos (HLA), que são responsáveis pela apresentação de antígenos específicos às células efetoras do sistema imunológico. Os genes HLA de classe I clássicos (HLA-A, -B e -C), responsáveis pela apresentação antigênica aos linfócitos T citotóxicos, são considerado como os mais polimórficos do genoma humano e de outros vertebrados. A variabilidade desses genes e elevada heterozigose é mantida por seleção mediada por microrganismos. Diferentemente dos genes clássicos, os genes HLA de classe I não clássicos (HLA-G, -E e -F) apresentam variabilidade reduzida e como função principal a tolerância imunológica, por meio de sua interação com receptores inibitórios presentes nas células NK e T. O HLA-G é o mais estudado entre esses genes e, devido sua importância como molécula imunomoduladora e sua importância em situações como gestação, e considerando evidências anteriores de seleção natural mantendo uma elevada heterozigose nas regiões regulatórias do HLA-G, avaliamos a presença de uma inserção Alu (AluyHG) próxima a este gene correlacionando os achados com a variabilidade contida nas suas regiões codificadora e 3’ não traduzida. A inserção AluyHG mostrou-se em desequilíbrio de ligação (LD) com os polimorfismos do gene HLA-G. Especificamente, o elemento inserido apresentou-se em LD com um haplótipo denominado G*01:01:01:01/UTR-1, considerado como um haplótipo de alta produção da molécula de HLA-G. Esse haplótipo aparentemente é o mais jovem entre humanos, apesar de sua elevada frequência nas populações estudadas até o momento.
Néel, Dominique. "Caracterisation des oligosaccharides n-lies d'antigenes hla-dr et de leurs cellules vectrices : contribution a l'etude des facteurs influencant la n-glycosylation". Paris 7, 1987. http://www.theses.fr/1987PA077138.
Pełny tekst źródłaLayet, Corine. "Approche des bases structurales de l'antigenicite des antigenes hla de classe i". Aix-Marseille 2, 1986. http://www.theses.fr/1986AIX22046.
Pełny tekst źródłaGarban, Frédéric. "Les molécules HLA de classe II dans les lymphocytes B de sang de cordon : présentation de l'antigène - transmission de signaux". Paris 7, 1997. http://www.theses.fr/1997PA077218.
Pełny tekst źródłaZeliszewski, Dominique. "Etude du polymorphisme et du role des molecules hla de classe 2 a l'aide de clones de lymphocytes t restreints et specifiques d'antigenes viraux". Paris 7, 1987. http://www.theses.fr/1987PA077248.
Pełny tekst źródłaQuillet, Anne. "Role des antigenes hla classe i dans la susceptibilite a la cytotoxine naturelle nk/lak". Paris 7, 1988. http://www.theses.fr/1988PA077142.
Pełny tekst źródłaHeldt, Christian. "Differentielle Expression von HLA-DRB-Genen". Doctoral thesis, [S.l.] : [s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=964994917.
Pełny tekst źródłaAmadou, Claire. "Structure et évolution du bras court du chromosome 6 humain : la région de classe I du complexe majeur d'histocompatibilité et sa partie distale". Toulouse 3, 1996. http://www.theses.fr/1996TOU30039.
Pełny tekst źródłaKrief, Patricia. "Modulation de l'expression des antigenes d'histocompatibilite induite par l'interferon gamma : role d'un inhibiteur endogene et de la differenciation". Paris 6, 1987. http://www.theses.fr/1987PA066459.
Pełny tekst źródłaMeneghini, Maria Antonia Emilia. "Tracking preformed serological and T-cell alloimmune memory together with donor/recipient Molecular Human Leukocyte Antigen (HLA) disparity to improve immune-risk stratification in Kidney Transplantation". Doctoral thesis, Universitat de Barcelona, 2021. http://hdl.handle.net/10803/673464.
Pełny tekst źródłaLas respuestas inmunológicas donante-especificas impactan negativamente en la evolución del aloinjerto renal. Estas pueden ser preformadas o activarse de novo tras el trasplante. Las técnicas inmunológicas disponibles en la clínica presentan limitaciones que no permiten una evaluación completa y precisa de esas respuestas. La hipótesis de esta tesis doctoral es que una evaluación de la memoria inmunológica mediante nuevas herramientas diagnosticas junto con estudios de compatibilidad HLA donante/receptor a nivel molecular para predecir el riesgo de aloinmunidad de novo, mejorarían la estratificación del riesgo inmunológico y permitirían personalizar la terapia inmunosupresora. Se han usado diferentes metódicas de detección de anticuerpos donante-específicos (DSA) pre-trasplante: cross-match por citometría de flujo, técnicas de fase solida y capacidad de los DSA de fijar complemento (C3d) in vitro y se ha medido la presencia de células T aloreactivas in vitro mediante ELISPOT Interferon(IFN)-y antes y después del trasplante. La incompatibilidad molecular HLA se ha valorado mediante algoritmos informáticos: incompatibilidad de aminoácidos, HLAMatchmaker y PIRCHE-II. Por ultimo, en un ensayo clínico prospectivo, guiado por biomarcadores de alorespuesta pre-trasplante (serológica y celular T) se han aleatorizado pacientes de bajo riesgo a recibir monoterapia con tacrolimus o tratamiento inmunosupresor convencional y comparado el riesgo de rechazo. La combinación de DSA (por fase solida) y cross-match por citometría son las técnicas que mejor se asocian el riesgo de pérdida del injerto, mientras que los DSA con elevado índice de fluorescencia y los que fijan complemento se asocian al riesgo de rechazo. Todos los algoritmos de incompatibilidad molecular HLA se asocian al riesgo de aloreactividad humoral primaria post-trasplante. De forma parecida, la incompatibilidad molecular (sobretodo por PIRCHE-II) se relaciona al riesgo de generar respuesta T donante-especifica de novo. En el ensayo CELLIMIN, los pacientes sin aloreactividad pre-trasplante (DSA/aloractividad T) presentaron inferior riesgo de rechazo. Sin embrago, aquellos pacientes que recibieron tacrolimus monoterapia presentaron una mayor incidencia de rechazo, especialmente en presencia de elevada incompatibilidad de epletos HLA-DQ. Un estudio completo de las respuestas de memoria tanto serológica como celular T donante-específica, junto con la evaluación de la incompatibilidad HLA a nivel molecular, podrían estratificar más precisamente el riesgo inmunológico de cada receptor frente a su donante y permitir adaptar el tratamiento inmunosupresor de una forma personalizada.
Cayrol, Corinne. "Les molécules HLA de classe II : production d'anticorps monoclonaux pour la caractérisation de nouveaux épitopes polymorphes et étude du trafic intracellulaire des molécules DR et DQ". Toulouse 3, 1992. http://www.theses.fr/1992TOU30121.
Pełny tekst źródłaSaglibene, Hélène. "Prévention du rejet de greffe de cornée et complexe majeur d'histocompatibilité". Bordeaux 2, 1992. http://www.theses.fr/1992BOR23061.
Pełny tekst źródłaTriebel, Frédéric. "Analyse fonctionnelle et structurale des antigènes membranaires ayant un rôle dans la réponse proliférative de clones lymphocytaires T humains spécifiques de l'anatoxine diphtérique". Paris 6, 1986. http://www.theses.fr/1986PA066147.
Pełny tekst źródłaPoizot-Martin, Isabelle. "Signalisation induite par les molécules HLA de classe II dans les cellules B lymphoïdes normales et malignes folliculaires". Université Joseph Fourier (Grenoble), 2000. http://www.theses.fr/2000GRE10170.
Pełny tekst źródłaJeanmougin, Marc. "Imputation HLA et analyse génomique de la coinfection VIH/VHC". Thesis, Paris, CNAM, 2017. http://www.theses.fr/2017CNAM1164/document.
Pełny tekst źródłaAssociation genomics aims at finding links between the genome and some traits or illnesses. Today, the most frequent studies in this field are genome wide association studies (GWAS), which analyze as many genome variants (mainly Single Nucleotide Polymorphisms) as possible, without any a priori on their biological function. However, genotyping methods used in these studies may be insufficient to get reliable information in higly variable regions such as the HLA which plays a crucial role in immunity, and the genetic variants of such regions are often predicted using bioinformatics approaches. During my PhD, I have created a new tool, HLA-Check, that allows to rate the plausibility of HLA alleles from the genotypes obtained from genotyping chips. I also assesses its performances and showed that it was able to point out individuals with a wrong HLA typing, in order to retype them or remove them from the study. An article documenting this tool was published in BMC Bioinformatics. I have also performed a genome-wide association study on cirrhosis outbreak in individuals coinfected with HIV (human immunodeficiency virus) and HCV (hepatitis C virus). Because of similar infection routes (blood-related), co-infection with those two viruses are frequent, and the infection by HIV enhances HCV activity and increases liver fibrosis leading to cirrhosis and death of co-infected patients. Our study has dealt with 306 co-infected patients from the ANRS CO-13 HEPAVIH cohort. I could point out three statistically significant signals, two of them being highly relevant for their involvement in liver diseases (gene CTNND2 and gene MIR7-3HG). The identification of these new variants should lead to a better understanding of the molecular mechanisms involved in cirrhosis, and should contribute to the rational developement of new diagnostic or therapeutic strategies. A publication is under way
Dilthey, Alexander Tilo. "Statistical HLA type imputation from large and heterogeneous datasets". Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:1bca18bf-b9d5-4777-b58e-a0dca4c9dbea.
Pełny tekst źródłaCiarlariello, Paul David. "IFN-Gamma-Mediated Immunoevasive Strategies in Multiple Myeloma". The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1460656019.
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