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Ayers, Amy L. "Windows hibernation and memory forensics". Thesis, Utica College, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1586690.
Pełny tekst źródłaABSTRACT The purpose of this capstone project was to research the hibernation file, its role in memory forensics and to explore current technology, techniques and concepts for analysis. This study includes an in-depth look at the Windows hibernation feature, file format, potential evidence saved to the file and its impacts in digital forensic investigations. This research was performed to demonstrate the importance of the hibernation file and to generate awareness for this forensic artifact. The research questions presented were designed to identify the properties of Windows hibernation and its significance in digital forensics. Additionally, these research questions were aimed at identifying the important concepts analysts should understand in selecting forensic software and in hibernation analysis. Through the literature review process, the hibernation file was identified as an essential part of digital forensics which provides analysts with snapshots of system memory from various points in the past. This data includes web, email and chat sessions in addition to running processes, login credentials, encryption keys, program data and much more. Beyond forensics, the hibernation file is useful in the fields of data recovery and incident response. A review of current hibernation file publications revealed incomplete and conflicting works culminating in the acknowledgment that more research is needed in order to close these research gaps. More awareness for hibernation forensics through its inclusion in future published works and in computer forensic educational courses is recommended. These inclusions will assist to arm practitioners with the ability to accurately utilize the hibernation file in order to obtain the highest quality forensic evidence. Keywords: Cybersecurity, hiberfil.sys, hybrid sleep, malware, slack space, Albert Orbinati.
Seger, Rita Logan. "Elucidating the Mechanism for Maintaining Eucalcemia Despite Immobility and Anuria in the Hibernating Black Bear (Ursus americanus)". Fogler Library, University of Maine, 2008. http://www.library.umaine.edu/theses/pdf/SegerRL2008.pdf.
Pełny tekst źródłaAl-Mohammad, Abdallah. "Hibernating myocardium : prevalence and surrogate markers". Thesis, University of Aberdeen, 2017. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=235453.
Pełny tekst źródłaSanders, Colin E. "Quiescent states of sleep, torpor and hibernation in the". Thesis, University of British Columbia, 2008. http://hdl.handle.net/2429/2331.
Pełny tekst źródłaGuillot, Patricia. "La biochimie de l'hibernation chez les mammifères". Paris 5, 1989. http://www.theses.fr/1989PA05P112.
Pełny tekst źródłaValek, Anton. "Hibernation of public space - an investigation of Stockholms water environment". Thesis, KTH, Arkitektur, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-298828.
Pełny tekst źródłaSueldo, Rolando. "Évolution de paramètres caractéristiques de la physiologie de l'eau lors de la dormance et de sa levée dans les tubercules de stachys sieboldi, MIQ. Et de helianthus tuberosus. Relations avec le métabolisme lipidique chez hélianthus". Clermont-Ferrand 2, 1990. http://www.theses.fr/1990CLF21234.
Pełny tekst źródłaMacDonald, Justin Anthony. "Enzyme thermal adaptations and signal transduction involvement in ground squirrel hibernation". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1998. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp02/NQ32342.pdf.
Pełny tekst źródłaCharge, T. Dic, i University of Lethbridge Faculty of Arts and Science. "Hibernation biology of Richardson's ground squirrels : hibernaculum systems and energy utilization". Thesis, Lethbridge, Alta. : University of Lethbridge. Faculty of Arts and Science, 2001, 2001. http://hdl.handle.net/10133/151.
Pełny tekst źródłaxii, 139 leaves : ill. ; 28 cm.
Saitongdee, Porncharn. "Cardiovascular changes during and after arousal from hibernation in golden hamsters". Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.392885.
Pełny tekst źródłaKarels, Timothy J. "Reproduction, hibernation, and population regulation of arctic ground squirrels (Spermophilus parryii plesius)". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0021/NQ53885.pdf.
Pełny tekst źródłaDonohoe, Paul Hugh. "Factors effecting metabolic rate reduction during hibernation in the frog, Rana temporaria". Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.627309.
Pełny tekst źródłaPitre, Marie-Hélène. "Composition lipidique et hibernation chez la petite chauve-souris brune (Myotis lucifugus)". Mémoire, Université de Sherbrooke, 2006. http://savoirs.usherbrooke.ca/handle/11143/4699.
Pełny tekst źródłaPitre, Marie-Hélène. "Composition lipidique et hibernation chez la petite chauve-souris brune (Myotis lucifugus)". [S.l. : s.n.], 2006.
Znajdź pełny tekst źródłaJackson, Diane Margaret. "The links between energetics and over-winter survival in small rodents". Thesis, University of Aberdeen, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327595.
Pełny tekst źródłaMartins, Regina Lucia. "Rôle du tissu adipeux brun dans la thermogenèse sans frisson au cours du réveil d'un rongeur hibernant : le Lérot (Eliomys quercinus L.)". Toulouse 3, 1990. http://www.theses.fr/1990TOU30188.
Pełny tekst źródłaHershey, John Davidson. "Minimal disuse muscle atrophy and seasonal alterations in the calcium handling system in skeletal muscle of hibernating brown bears". Pullman, Wash. : Washington State University, 2008. http://www.dissertations.wsu.edu/Dissertations/Fall2008/J_Hershey_020309.pdf.
Pełny tekst źródłaHumphries, Murray M. "Food hoarding and hibernation in chipmunks and the ecological consequences of energetic flexibility". Thesis, McGill University, 2001. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=38068.
Pełny tekst źródłaBaker, Christopher Stephen Rainald. "A study of nitric oxide metabolism in myocardial stunning, hibernation and coronary atherosclerosis". Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391143.
Pełny tekst źródłaPark, Kirsty Janet. "Roosting ecology and behaviour of four temperate species of bat". Thesis, University of Bristol, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.244877.
Pełny tekst źródłaMountassif, Driss. "Régulation de la D-3-hydroxybutyrate déshydrogénase chez la gerboise (Jaculus orientalis) : étude biochimique, toxicologique et moléculaire". Dijon, 2007. http://www.theses.fr/2007DIJOS063.
Pełny tekst źródłaMitochondria represent the seat of the production of ketone bodies (3-hydroxybutyrate and acetoacetate) which play an important role in the energy metabolism and the cellular biosynthesis. These ketone bodies are the final products of the degradation of fatty acids. Their production is regulated by D-3-hydroxybutyrate dehydrogenase (BDH): oxydo-reductase, situated at the inner mitochondrial membrane. The BDH is used as probe to study the effect of exogenous substances and variations of the physiological states on the cellular energy metabolism. In this work, we isolated and characterized two mitochondrial populations: the heavy and the light mitochondria in the liver of the jerboa (Jaculus orientalis, true hibernator rodent) at active, prehibernating and hibernating states. We also characterized these three states in term of metabolic changes especially at the level of the BDH (change at the level of the expression and the catalytic properties). We also studied the in vivo and in vitro effect on the jerboa and BDH of two hypolipidemic molecules (ciprofibrate and 2,4D). The ciprofibrate is a medicine of the class of fibrates very used in Morocco to cure dyslipidemia, and the 2,4D is used in agriculture to treat parasites to improve the harvests. Finally, we developed a new method for the purification of the BDH from Jaculus orientalis (eucaryote) using polyclonal antibodies against the BDH purified from Pseudomonas aeruginosa (procaryote). We completed this study by the amplification by RT-PCR, cloning and sequencing of the cDNA coding the BDH of the jerboa. The comparison between the obtained sequence and others showed an important conservation of amino acids which play important role in BDH catalysis and subsequently in the energy metabolism
Reidy, Shannon Patricia. "The effects of prolonged fasting, hibernation and leptin on in vivo lipid metabolism in mammals". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0020/NQ57163.pdf.
Pełny tekst źródłaCastaing, Laurent. "Hibernation et reproduction du hérisson (erinaceus europaeus L. ) : interrelations et régulation par les facteurs externes". Tours, 1985. http://www.theses.fr/1985TOUR4008.
Pełny tekst źródłaChazarin, Blandine. "Développements en protéomique pour mieux comprendre la physiologie de l’ours brun hibernant et ouvrir la voie vers de nouvelles thérapies contre l’atrophie musculaire humaine". Thesis, Strasbourg, 2019. http://www.theses.fr/2019STRAF037.
Pełny tekst źródłaTo analyze samples from "exotic" organisms using proteomics, analytical developments are required. Our developments were made to study protein saving mechanisms in hibernating brown bears. The complementarity of proteomics approaches (SDS PaGE-XIC, 2D-DIGE-MS, LC-SRM-MS) and bioinformatics developments (e.g. use of genome assembly data, extraction of functional annotations [Gene Ontology, neXtProt, KEGG]) have led to show that muscle beta-oxidation is preferential, glycolysis being maintained. High levels of omega 3 fatty acids, decreased oxidative stress, and the existence of anti-proteolytic compounds in the serum of hibernating bears contribute to muscle sparing. To identify these compounds, we developed fractionation of the bear serum (chromatography, proteolysis, high abundance protein depletion) and showed that ketone bodies could be involved. These results suggest new therapeutic solutions against muscle atrophy in immobilized people, the elderly or astronauts
Webb, Cheryl Lynn. "Aspects of the control of breathing in the golden-mantled ground squirrel". Thesis, University of British Columbia, 1987. http://hdl.handle.net/2429/26662.
Pełny tekst źródłaScience, Faculty of
Zoology, Department of
Graduate
El, Kebbaj Zakaria. "La β-oxydation peroxysomale des acides gras : rôle de l’acyl-CoA oxydase et régulation par les PPARs chez la gerboise (Jaculus orientalis)". Dijon, 2007. http://www.theses.fr/2007DIJOS064.
Pełny tekst źródłaAs true hibernator, jerboa (Jaculus orientalis) is an excellent animal model to study lipid metabolism adaptation to low body temperature. During hibernation state, jerboa body temperature drops from 37°C to 10°C and its heart frequency decreases from 300 to 10 beat/min. Hibernation, in Jaculus orientalis, is preceded by prehibernating period during which the animal increases its fat content indicating a natural seasonal obesity. In this context, we have studied a peroxisomal fatty acids β-oxidation and its regulation during hibernation by the nuclear receptor PPARalpha (peroxisome-proliferator activated receptor). Our results describe for the first time the occurrence of two PPARalpha isoforms in rodent liver like jerboa (absent in rat and mice): PPARalpha1wt (active) and PPARalpha2tr (playing a dominant negative role on PPARalpha1wt). We have shown the importance of the ratio of PPARalpha1wt / PPARalpha2tr in the control of its target genes (ACOX-1, BFE, catalase, PMP70). Thus, during hibernating state, the increased availability of active PPARa1wt, is a result of a decline in the PPARalpha2 mRNA and its protein expression accompanied by a concomitant induction of PPARalpha thermogenic coactivator PGC-1alpha. Our results strongly suggest that PPARalpha is subject to a hibernation-dependent splicing regulation in response to feeding-fasting conditions, which defines the activity of PPARalpha and the activation of the hepatic peroxisomal β-oxidation pathway. Interestingly, sustained activation of PPARalpha by its hypolipidemic ligand, ciprofibrate, abrogates the adaptive fasting response of PPARalpha during prehibernation and overinduces its target genes, disrupting the prehibernation fattening process. Elsewhere, in heart, such fatty acids peroxisomal degradation system is involved in the energy supply, particularly during hibernation. Indeed, we were able to identify in heart the presence of a hibernation-dependent peroxisomal acyl-CoA oxidase-1 (ACOX-1) isoenzyme. Underlining the remarkable role of peroxisome fatty acid β-oxidation during the critical hibernation period. In addition, we partially purified the liver ACOX-1 and conducted a biochemical study. Hepatic ACOX-1 follows an allosteric kinetic at 37 ° C, whereas at 10 ° C it follows a michaelien kinetic, this makes the temperature an allosteric effector of ACOX-1 activity
Pagès, Marie. "Apport de données d'ADN nucléaire à la phylogénie et à la biologie de la conservation des Ursidae". Montpellier 2, 2007. http://www.theses.fr/2007MON20147.
Pełny tekst źródłaCurrently, the Ursidae family includes eight bear species. They represent an unusual family within the order of the Carnivores because of their peculiar physiological adaptations related to hibernation. These physiological features, unique in the animal kingdom, make bear a unique model for medical research in full expansion because of its putative clinical applications. This point will be developed in introduction of this manuscript. Surprisingly, the phylogenetic relationships within the extant Ursid representatives remain unclear. In order to clarify their phylogeny, we sequenced 12 nuclear genes for all the Ursid species (nearly 8 kilobases corresponding to 6 genes implied in the pathway of the thyroid hormones, 3 genes specific to the sexual chromosomes, and 3 other autosomal genes). By concatenating these new data with those available in the sequence databanks, phylogenetic reconstructions (maximum likelihood and bayesian analyses) were carried out on a nuclear DNA dataset of 10 kilobases. It was then possible to refine the phylogeny of the Ursidae family. In addition, based on the study of the genes SRY (Sex determining region of the Y chromosome), ZFX/ZFY (Zinc Finger protein) and AMLX/AMLY (Amelogenine), we developed a reliable method to determine the sex of Ursidae based on the analysis of DNA extracted from non invasive samples such as hairs or faeces. If this tool has obvious implication for the conservation biology of Ursidae (most of the extant species are threatened with extinction), it also opens new prospects in palaeontology. This kind of analysis was indeed applied to samples of fossils of North African brown bears (Ursus arctos). The last chapter of this manuscript illustrates how the palaeogenetics can help palaeontology interpreting the variability of fossil forms
Bethany, Williams. "Nitric oxide metabolites in hypoxia, freezing, and hibernation of the wood frog, Rana sylvatica". Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami1525202133341325.
Pełny tekst źródłaBaker, Patrick J. III. "Physiology and Ecology of Terrestrially-hibernating Hatchling Turtles". Miami University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=miami1239276024.
Pełny tekst źródłaBae, Jung Yoon. "Reversible Regulation of Cell Cycle-Related Genes by Epigallocatechin Gallate for Hibernation of Neonatal Human Tarsal Fibroblasts". Kyoto University, 2009. http://hdl.handle.net/2433/124083.
Pełny tekst źródłaGiordano, Céline. "Pre-Clinical Evaluation of Biopolymer Delivered Circulating Angiogenic Cells in Hibernating Myocardium". Thèse, Université d'Ottawa / University of Ottawa, 2011. http://hdl.handle.net/10393/20619.
Pełny tekst źródłaAtgié, Claude. "Prise alimentaire et niveau de l'activité adrénergique périphérique chez un rongeur hibernant, le Lérot Eliomys quercinus L". Toulouse 3, 1990. http://www.theses.fr/1990TOU30059.
Pełny tekst źródłaEnglish, Tamara Erica Carleton University Dissertation Biology. "Enzymes of adenylate metabolism from the skeletal muscle of the hibernating prairie dog, Cynomys leucurus". Ottawa, 1995.
Znajdź pełny tekst źródłaCarey, Charleve. "IS DISRUPTION TO PASSIVE GAS-EXCHANGE A MECHANISM OF DEHYDRATION FOR WNS-INFECTED HIBERNATING BATS?" OpenSIUC, 2014. https://opensiuc.lib.siu.edu/theses/1532.
Pełny tekst źródłaWeitten, Mathieu. "Adaptations métaboliques et influence du régime alimentaire chez un hibernant food-storing". Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAJ080/document.
Pełny tekst źródłaThis thesis presents the specific adaptations of food-storing hibernators that feed during hibernation, and the impact of diet quality on their annual cycle. In contrast to the fat-Storing species which fast during hibernation, the food-storing presents metabolic responses to an alternation of short fasting phases and hyperphagia. These responses involve one hand use of fat reserves during hibernation contributing to ketogenesis, which would be induced by adiponectin. On the other hand, maintaining a functional digestive system leading to the secretion of incretins, permits optimal nutrient absorption in the short inter-torpor euthermia. Increased glucose uptake in particular would restore body reserves to spare. Moreover, a lean protein diet enriched in fat and induces increased in body mass in pre-hibernation period causing reduced use of torpor thus an increased loss of mass during hibernation, and decreased reproductive success
Stratton, Kalera. "The Influence of Hibernation Temperature on Deiodinase 2 in Red-Sided Garter Snakes (Thamnophis sirtalis parietalis)". PDXScholar, 2019. https://pdxscholar.library.pdx.edu/open_access_etds/4865.
Pełny tekst źródłaHausmann, Harald. "Myokardrevaskularisation bei hochgradig eingeschränkter linksventrikulärer Funktion". Doctoral thesis, Humboldt-Universität zu Berlin, Medizinische Fakultät - Universitätsklinikum Charité, 2004. http://dx.doi.org/10.18452/13909.
Pełny tekst źródłaObjectives: Factors that influence functional recovery of hibernating myocardium after coronary artery bypass grafting are at present under investigation. Methods: From 3/2000 to 3/2003 we prospectively analyzed 41 patients with ejection fraction (EF) 15% during DE in group I preoperatively; the increase was < 15% in group II. MRI hyperenhancement was measured with a mean of 16,7±11,6% of the left ventricle in group I compared to a mean of 27,4±14,4% in group II (p 19µm) in group I than in group II (< 17µm). Gene expression of pro-apoptotic genes such as BAK and BAX was lowered (0.5±0.1/0.8±0.1) compared to "normal" myocardium (1.0±0.1) (p
Landry-Cuerrier, Manuelle. "From habitat to energetics : eastern chipmunk burrow microhabitat selection and fine-scale variation in winter torpor expression". Thesis, McGill University, 2008. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=112530.
Pełny tekst źródłaMills, Cheryl Anne. "Conservation and ecology of the hazel dormouse, Muscardinus avellanarius". Thesis, University of Exeter, 2012. http://hdl.handle.net/10036/3907.
Pełny tekst źródłaMeyer, Michael. "Die Rolle des Toll-like-Rezeptor 4 bei chronisch-reduzierter Koronardurchblutung ("hibernation") : Beobachtungen an einem murinen In-vitro-Modell /". Bonn, 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000253862.
Pełny tekst źródłaGaglia, Marta Maria. "Dopamine modulation of quiescence in dauer larvae, and other investigations on hibernation and lifespan in the nematode Caenorhabditis elegans". Diss., Search in ProQuest Dissertations & Theses. UC Only, 2008. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3339187.
Pełny tekst źródłaCochet, Nathalie. "Lipolyse et acides gras dans deux dépôts adipeux blancs au cours du cycle saisonnier de la marmotte alpine (Marmota marmota)". Lyon 1, 1996. http://www.theses.fr/1996LYO10193.
Pełny tekst źródłaVignault, Marie-Paule. "Gestion des réserves au cours du cycle annuel chez un animal hibernant, le hérisson (Erinaceus europaeus L. )". Tours, 1994. http://www.theses.fr/1994TOUR4005.
Pełny tekst źródłaFatkhullin, Bulat. "Structural and functional studies of the ribosome silencing factor RsfS from the pathogenic bacteria Staphylococcus aureus". Electronic Thesis or Diss., Strasbourg, 2023. http://www.theses.fr/2023STRAJ018.
Pełny tekst źródłaCurrently, due to the active and sometimes uncontrolled use of antibiotics, the number of S. aureus strains with high resistance to antibacterial drugs increases every year. Persister cells play an important role in this process. Even in the absence of antibiotic resistance, these cells survive, causing recurrent infections, since they have blocked the binding sites of most therapeutic drugs affecting the S. aureus ribosome. Therefore, combating the cellular mechanisms responsible for the transition of cells to a persister state is a priority for research. One such mechanism is related to the functioning of the RsfS factor. In this study, the first 3.2 Å resolution cryo-EM structure of the 50S and RsfS complex and X-ray 2.3 Å resolution structure of the RsfS and uL14 complex were obtained. The RsfS Tyr 98 amino acid region is a critical site for preserving the anti-associative functions of the S. aureus RsfS factor. The obtained in this work results could form the basis for the development of new types of drugs capable of attenuating the pathogenic properties of S. aureus
Nicolai, Annegret. "The impact of diet treatment on reproduction and thermo-physiological processes in the land snails Cornu aspersum and Helix pomatia". Rennes 1, 2010. https://tel.archives-ouvertes.fr/tel-00525296.
Pełny tekst źródłaLes organismes rencontrent souvent de l’hétérogénéité dans l’espace et dans le temps et devront adapter leur traits d’histoire de vie. Chez Cornu aspersum, la stratégie de reproduction dépend des contraintes saisonnières, et l’investissement dans la reproduction est influencé par l’énergie disponible dans l’environnement. Des nutriments déposés dans les oeufs pourraient augmenter la probabilité de survie des juvéniles. Chez Helix pomatia, qui est utilisé dans des élevages biologiques afin de maintenir cette espèce menacée comme spécialité régionale sous le nom Albschneck®, le succès reproducteur est faible même avec une alimentation riche en énergie. Helix pomatia préserve des bactéries nucléantes dans l’intestin et accumule des cryoprotecteurs pour améliorer la résistance au froid pendant l’hiver. La mortalité pourrait être liée à un ajustement perpétuel des processus physiologiques aux importantes variations environnementales ainsi qu’à une allocation limitée vers des processus de survie
Pasniciuc, Silviu Valeriu. "Complex mechanisms of metabolic regulation in nonperfused muscle". The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1049304386.
Pełny tekst źródłaBoyer, Christian. "Identification et caractérisation de composés circulants d’intérêt dans le sérum d’ours brun hibernant – Étude des effets biologiques du sérum d’ours hibernant sur cellules humaines". Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2023. http://www.theses.fr/2023UCFA0012.
Pełny tekst źródłaMuscle atrophy, which is a major public health issue, is a condition that affects the elderly, but also people who are sedentary, immobilized or suffering from chronic inflammation. The use of animal models, in particular laboratory rodents, has made it possible to elucidate the molecular and physiopathological mechanisms at the origin of muscle atrophy. In the search for therapeutic solutions, the exploration of a model of natural resistance to muscle atrophy should open up new and innovative avenues of research. The laboratory is exploring how the hibernating brown bear is able to preserve its muscle tissue during several months of immobility, and how its serum is able to induce changes in the protein balance of human muscle cells. The main objective of my thesis work was to identify compounds or families of compounds circulating in the hibernating bear and responsible for biological effects on human cells. First, I looked for a biological activity that could be easily measured and that could be used to screen the circulating compounds. The measurement of NADH dehydrogenase activity by a colorimetric assay, allows to follow the inhibitory effects of serum and its fractions on human cells in culture, in a robust and reproducible way. Thanks to this tool, we were able to initiate the screening of several fractions from hibernating bear serum, thus starting an unbiased approach in the search for active compounds in hibernating bear serum. This work opens the way to the testing of new fractions, allowing to advance towards the identification of new molecules having a positive effect on the cellular energy balance. According to the same approach, the development of several measurement tools covering other domains of cellular metabolism should allow to complete this approach in the future. In parallel, in the search for active circulating compounds present in the serum of hibernating bears, I focused my research on compounds related to the endocannabinoid system. I was thus able to highlight a global decrease of the endocannabinoid tone, with a decrease of the ligands of the canonical pathway. Surprisingly, the concentration of circulating oleoylethanolamide (OEA) is multiplied by three in winter, suggesting an important role of this compound in the physiology of hibernation in brown bears. The continuation of this work should allow to better identify circulating compounds of interest for human medicine, and to advance towards innovative therapeutic solutions in the fight against certain pathologies, such as muscle atrophy
Doherty, Alison H. "The Skeletal Biology of Hibernating Woodchucks (Marmota monax)". Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1355252380.
Pełny tekst źródłaWiebler, James. "UREA HYDROLYSIS BY GUT BACTERIA: FIRST EVIDENCE FOR UREA-NITROGEN RECYCLING IN AMPHIBIA". Miami University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=miami152535331130121.
Pełny tekst źródłaMesa, Cruz Jose Bernardo. "Assessment of Physiological Challenges in Overwintering Black Bears (Ursus americanus): Active Gestation, Neonatal Growth, and Skeletal Muscle Conservation". Diss., Virginia Tech, 2018. http://hdl.handle.net/10919/96197.
Pełny tekst źródłaPh. D.