Rozprawy doktorskie: „Headaches”

1

Rossazza, Michèle. "Approche chronobiologique des cluster headaches". Bordeaux 2, 1989. http://www.theses.fr/1989BOR23090.

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2

Gurr, Birgit. "Psychological characteristics of posttraumatic headaches and the effectiveness of cognitive-behavioural therapy for posttraumatic headaches". Thesis, Bangor University, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.401917.

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3

Munch, Rod J. "Hypnosis : an effective intervention for migraine headaches". Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/28183.

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The general distribution of the headache worldwide, its widespread occurrence, and its frequency of incidence is well documented. It is a disorder that often goes unreported with pharmaceutical intervention being the most commonly applied remedy. The National Migraine Foundation estimates that 42 million Americans suffer from headaches. Of these 8 to 12 million Americans are afflicted by the migraine headache. This study examined the effectiveness of hypnotherapy as an intervention for migraines. It was a single case holistic study in which a 23 year old female migraineur provided the single unit of analysis. Assessments of self concept; stress; headache frequency, duration, and intensity; and consumption of pharmacological substances were made prior to treatment, during treatment, and following treatment. The therapy consisted of eight sessions over 2 1/2 weeks and consisted of a relaxation induction and guided imagery of control of physiological responses. An audiotape of the hypnotherapy intervention was also used on a dally basis by the client. Results from post therapy and follow-up tests confirmed the treatment was effective. This was maintained at the one and two month follow-ups.
Education, Faculty of
Educational and Counselling Psychology, and Special Education (ECPS), Department of
Graduate

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4

Björling, Elin A. "Exploring stress and headaches in adolescent females /". Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/7285.

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5

Lea, Rod A. "An Investigation of Migraine Candidate Genes and Genomic Susceptibility Regions". Thesis, Griffith University, 2003. http://hdl.handle.net/10072/367547.

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Typical migraine, comprised of migraine with aura (MA) and migraine without aura (MO), is a chronic, painful and debilitating neurovascular disease which is generally characterised by recurrent attacks of severe headache usually accompanied by nausea, vomiting, photo and phonophobia. Migraine has been shown to affect a large proportion of Caucasian populations with a recent comprehensive study indicating that around 25% of women and 8% of men suffer from the disease. Strong familial aggregation of typical migraine and an increased concordance for the disease in MZ twins over DZ twins, suggests that it has a significant genetic component. Heritability estimates are calculated to be between 40% and 60%, indicating that disease variation, in part, is explained by environmental determinants. The mode of transmission of typical migraine is not clear but is most likely multifactorial. Although the MA and MO subtypes exhibit some clinical heterogeneity, segregation analysis has suggested that there may be a common genetic aetiology for MA and MO, and a major gene contributing to typical migraine pathogenesis. This idea is substantiated by the fact that both subtypes of migraine can occur within the same family and even within the same individual, with up to 33% of sufferers experiencing both types of the disease. In addition, migraine prophylactics have been shown to result in similar effects in patients treated for both types of migraine. However, whether the two subtypes are truly separate entities or not remains unclear. At present, the type and number of genes involved in typical migraine is not known. Despite this, several studies into Familial Hemiplegic Migraine (FHM), a very severe subtype of MA, have led to the discovery that mutations in a brain specific calcium channel subunit gene (CACNA1A) located on chromosome 19, cause FHM in about 50% of affected families. FHM is a rare disease and is distinguished from typical migraine by its association with hemiparesis and clear autosomal dominant mode of inheritance. However, certain clinical features are common to both FHM and typical migraine including similarities in headache characteristics and triggers. Hence, FHM genetic studies provide a valuable model for investigating the genes involved in the more prevalent types of migraine with and without aura. For this reason the Genomics Research Centre has been conducting linkage studies utilising large Australian migraine pedigrees with a focus on the known FHM (CACNA1A) gene region on chromosome 19p13. Our results to date have indicated suggestive linkage to the FHM region on 19p13 in a large multigenerational pedigree (MF1) affected with typical migraine, with a maximum parametric LOD score of 1.92 (P = 0.001) obtained for a triplet repeat polymorphism situated in exon 47 of the CACNA1A gene. Expansion of this repeat was not observed, but is possible that mutations elsewhere in the CACNA1A gene may be responsible for migraine in this pedigree. To investigate this possibility, the current research involved sequencing two patients carrying the critical susceptibility haplotype surrounding the CACNA1A gene. The results of this mutation screen revealed no disease causing mutations or polymorphisms in any of the 47 exons screened. To determine whether the CACNA1A genomic region was implicated in typical migraine susceptibility in the general Caucasian population, 82 independent pedigrees and a large case-control group were also analysed using highly polymorphic microsatellite markers. There was no linkage or association detected in these groups and thus, it was concluded that if CACNA1A plays a role in typical migraine it does not confer a major effect on the disease. However, subsequent case-control studies of SNPs in the INSR gene, which is located ~15cM telomeric from CACNA1A, provided evidence of association to typical migraine. Thus, the INSR gene may now emerge as the new migraine susceptibility gene in this genomic region on chromosome 19. Family linkage studies conducted by Gardner et al have implicated an additional FHM susceptibility region on chromsome 1q31. Furthermore, independent research carried out by Ducros et al. has indicated a second FHM locus at 1q21-23, which is ~ 30cM centromeric to the region reported by Gardner et al. At this stage it is not clear whether there is a single locus, or two distinct loci, on the chromosome 1q region. This research also involved a family-based linkage and association approach to investigating the FHM susceptibility region on chromosome 1q31 for involvement in typical migraine susceptibility in affected Australian pedigrees. Initial multipoint ALLEGRO analysis provided strong evidence for linkage of Chr1q31 markers to typical migraine in a large multigenerational pedigree. The 1-LOD* unit support interval for suggestive linkage spanned ~18cM with a maximum allele sharing LOD* score of 3.36 obtained for marker D1S2782, P = 0.00004. Subsequent analysis of an independent sample of 82 affected pedigrees added support to the initial findings with a maximum LOD* of 1.24 (P = 0.008). Utilising the independent sample of 82 pedigrees we also performed a family-based association test. Results of this analysis indicated distortion of allele transmission at marker D1S249 (global c2(5) of 15.00, P = 0.010) in these pedigrees. These positive linkage and association results will need further confirmation by independent researchers, but overall they provide good evidence for the existence of a typical migraine locus near these markers on Chr1q31, and reinforce the idea that an FHM gene in this genomic region may also contribute to susceptibility to the more common forms of migraine. The serotonergic system has long been implicated in the pathophysiology of migraine. Researchers have therefore focused on the serotonin receptors and the genes that code for them when investigating this disease. Although serotonin receptor agonists have proven to be effective in the treatment of migraine, there has been little evidence of a serotonin receptor gene being associated with the disorder. However, in 1998, Ogilvie et al reported that a VNTR in the serotonin transporter gene (SERT) showed altered allelic distributions in a Danish migraine population. In addition to serotonin, there has been renewed interest in the involvement of the dopaminergic pathways in migraine. This interest has gained impetus since the study of Peroutka et al who reported an allelic association between the dopamine receptor gene DRD2 and migraine with aura. Another dopamine related gene, the dopamine beta-hydroxylase gene (DBH), has been localised to Chr 9q34 and codes for the enzyme that catalyses the conversion of dopamine to norepinephrine. It therefore plays an important role in dopaminergic and noradrenergic neurotransmission. Serum levels of DbH enzyme have been reported to be elevated in migrainous patients during the headache phase of an attack. Also, significantly increased DbH enzyme activity has been observed in migraine patients during the headache-free interval. Thus, the DBH gene is another good candidate for involvement in migraine pathophysiology and, to our knowledge, has not been previously implicated in this disease. Candidate gene studies may be useful strategies for identifying genes involved in complex diseases such as migraine, especially if the gene being examined contributes only a minor effect to the overall phenotype. This research also involved a linkage and association approach to investigating neurotransmitter related migraine candidate genes. Specifically, polymorphisms within the serotonin transporter gene (SERT), the dopamine receptor gene (DRD2) and the dopamine beta-hydroxylase (DBH) gene were tested in unrelated Caucasian migraineurs and non-migraine control individuals. In addition, an independent sample of 82 families affected with migraine were examined. Unrelated case-control association analysis of a DBH intragenic dinucleotide polymorphism indicated altered allelic distribution between migraine and control groups (c2 = 16.53, P = 0.019). Furthermore, the transmission/disequilibrium test (TDT) which was implemented on the family data also indicated distortion of allele transmission for the same DBH marker (c2 = 4.44, P = 0.035). Together, these results provide evidence for allelic association of the DBH gene with typical migraine susceptibility (Fisher's Combined P-value = 0.006) and indicate that further research into the role of the DBH gene in migraine aetiology is warranted. Nitric oxide (NO) is emerging as a key molecule affecting the pain associated with migraine. Since nitric oxide synthase (NOS) enzymes catalyse the synthesis of NO, the genes that code for these enzymes are good candidates for migraine molecular genetic analysis. This research involved investigating the role of a functionally relevant bi-allelic tetranucleotide polymorphism located in the promoter region of the human inducible nitric oxide synthase (iNOS) gene in migraine aetiology. A large group of migraine affected individuals were genotyped and compared to an age and sex matched group of unaffected controls. Results of a chi-squared analysis indicated that allele distributions for both migraine cases and controls were not significantly different (c2 = 1.93, P = 0.16). These findings offer no evidence for an allelic association of the tested iNOS polymorphism with the common forms of the disease and therefore do not support a role for this gene in migraine pathogenesis. In summary, this research involved linkage and association analysis of migraine candidate genes and genomic susceptibility regions. Whilst, the known FHM gene (CACNA1A) was excluded for significant involvement in typical migraine the adjacent INSR gene has been associated. Migraine is genetically heterogeneous and the results of this research also provide good evidence that the DBH gene is involved in disease predisposition, whilst the DRD2, SERT and INOS gene were not shown to be implicated. An additional susceptibility region for typical migraine is also likely to localise to chromosome 1q31. Overall, the results presented in this thesis have contributed valuable data to the understanding of the molecular genetics of migraine with and without aura. Future research into the molecular pathophysiological mechanisms of migraine will greatly facilitate the development of more effective diagnosis and treatment strategies.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Health Sciences
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6

Svensson, Dan A. "Genetic and environmental influences on major recurrent headaches /". Stockholm, 2004. http://diss.kib.ki.se/2004/91-7349-773-8/.

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7

Lea, Rod A., i n/a. "An Investigation of Migraine Candidate Genes and Genomic Susceptibility Regions". Griffith University. School of Health Science, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030526.153246.

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Typical migraine, comprised of migraine with aura (MA) and migraine without aura (MO), is a chronic, painful and debilitating neurovascular disease which is generally characterised by recurrent attacks of severe headache usually accompanied by nausea, vomiting, photo and phonophobia. Migraine has been shown to affect a large proportion of Caucasian populations with a recent comprehensive study indicating that around 25% of women and 8% of men suffer from the disease. Strong familial aggregation of typical migraine and an increased concordance for the disease in MZ twins over DZ twins, suggests that it has a significant genetic component. Heritability estimates are calculated to be between 40% and 60%, indicating that disease variation, in part, is explained by environmental determinants. The mode of transmission of typical migraine is not clear but is most likely multifactorial. Although the MA and MO subtypes exhibit some clinical heterogeneity, segregation analysis has suggested that there may be a common genetic aetiology for MA and MO, and a major gene contributing to typical migraine pathogenesis. This idea is substantiated by the fact that both subtypes of migraine can occur within the same family and even within the same individual, with up to 33% of sufferers experiencing both types of the disease. In addition, migraine prophylactics have been shown to result in similar effects in patients treated for both types of migraine. However, whether the two subtypes are truly separate entities or not remains unclear. At present, the type and number of genes involved in typical migraine is not known. Despite this, several studies into Familial Hemiplegic Migraine (FHM), a very severe subtype of MA, have led to the discovery that mutations in a brain specific calcium channel subunit gene (CACNA1A) located on chromosome 19, cause FHM in about 50% of affected families. FHM is a rare disease and is distinguished from typical migraine by its association with hemiparesis and clear autosomal dominant mode of inheritance. However, certain clinical features are common to both FHM and typical migraine including similarities in headache characteristics and triggers. Hence, FHM genetic studies provide a valuable model for investigating the genes involved in the more prevalent types of migraine with and without aura. For this reason the Genomics Research Centre has been conducting linkage studies utilising large Australian migraine pedigrees with a focus on the known FHM (CACNA1A) gene region on chromosome 19p13. Our results to date have indicated suggestive linkage to the FHM region on 19p13 in a large multigenerational pedigree (MF1) affected with typical migraine, with a maximum parametric LOD score of 1.92 (P = 0.001) obtained for a triplet repeat polymorphism situated in exon 47 of the CACNA1A gene. Expansion of this repeat was not observed, but is possible that mutations elsewhere in the CACNA1A gene may be responsible for migraine in this pedigree. To investigate this possibility, the current research involved sequencing two patients carrying the critical susceptibility haplotype surrounding the CACNA1A gene. The results of this mutation screen revealed no disease causing mutations or polymorphisms in any of the 47 exons screened. To determine whether the CACNA1A genomic region was implicated in typical migraine susceptibility in the general Caucasian population, 82 independent pedigrees and a large case-control group were also analysed using highly polymorphic microsatellite markers. There was no linkage or association detected in these groups and thus, it was concluded that if CACNA1A plays a role in typical migraine it does not confer a major effect on the disease. However, subsequent case-control studies of SNPs in the INSR gene, which is located ~15cM telomeric from CACNA1A, provided evidence of association to typical migraine. Thus, the INSR gene may now emerge as the new migraine susceptibility gene in this genomic region on chromosome 19. Family linkage studies conducted by Gardner et al have implicated an additional FHM susceptibility region on chromsome 1q31. Furthermore, independent research carried out by Ducros et al. has indicated a second FHM locus at 1q21-23, which is ~ 30cM centromeric to the region reported by Gardner et al. At this stage it is not clear whether there is a single locus, or two distinct loci, on the chromosome 1q region. This research also involved a family-based linkage and association approach to investigating the FHM susceptibility region on chromosome 1q31 for involvement in typical migraine susceptibility in affected Australian pedigrees. Initial multipoint ALLEGRO analysis provided strong evidence for linkage of Chr1q31 markers to typical migraine in a large multigenerational pedigree. The 1-LOD* unit support interval for suggestive linkage spanned ~18cM with a maximum allele sharing LOD* score of 3.36 obtained for marker D1S2782, P = 0.00004. Subsequent analysis of an independent sample of 82 affected pedigrees added support to the initial findings with a maximum LOD* of 1.24 (P = 0.008). Utilising the independent sample of 82 pedigrees we also performed a family-based association test. Results of this analysis indicated distortion of allele transmission at marker D1S249 (global c2(5) of 15.00, P = 0.010) in these pedigrees. These positive linkage and association results will need further confirmation by independent researchers, but overall they provide good evidence for the existence of a typical migraine locus near these markers on Chr1q31, and reinforce the idea that an FHM gene in this genomic region may also contribute to susceptibility to the more common forms of migraine. The serotonergic system has long been implicated in the pathophysiology of migraine. Researchers have therefore focused on the serotonin receptors and the genes that code for them when investigating this disease. Although serotonin receptor agonists have proven to be effective in the treatment of migraine, there has been little evidence of a serotonin receptor gene being associated with the disorder. However, in 1998, Ogilvie et al reported that a VNTR in the serotonin transporter gene (SERT) showed altered allelic distributions in a Danish migraine population. In addition to serotonin, there has been renewed interest in the involvement of the dopaminergic pathways in migraine. This interest has gained impetus since the study of Peroutka et al who reported an allelic association between the dopamine receptor gene DRD2 and migraine with aura. Another dopamine related gene, the dopamine beta-hydroxylase gene (DBH), has been localised to Chr 9q34 and codes for the enzyme that catalyses the conversion of dopamine to norepinephrine. It therefore plays an important role in dopaminergic and noradrenergic neurotransmission. Serum levels of DbH enzyme have been reported to be elevated in migrainous patients during the headache phase of an attack. Also, significantly increased DbH enzyme activity has been observed in migraine patients during the headache-free interval. Thus, the DBH gene is another good candidate for involvement in migraine pathophysiology and, to our knowledge, has not been previously implicated in this disease. Candidate gene studies may be useful strategies for identifying genes involved in complex diseases such as migraine, especially if the gene being examined contributes only a minor effect to the overall phenotype. This research also involved a linkage and association approach to investigating neurotransmitter related migraine candidate genes. Specifically, polymorphisms within the serotonin transporter gene (SERT), the dopamine receptor gene (DRD2) and the dopamine beta-hydroxylase (DBH) gene were tested in unrelated Caucasian migraineurs and non-migraine control individuals. In addition, an independent sample of 82 families affected with migraine were examined. Unrelated case-control association analysis of a DBH intragenic dinucleotide polymorphism indicated altered allelic distribution between migraine and control groups (c2 = 16.53, P = 0.019). Furthermore, the transmission/disequilibrium test (TDT) which was implemented on the family data also indicated distortion of allele transmission for the same DBH marker (c2 = 4.44, P = 0.035). Together, these results provide evidence for allelic association of the DBH gene with typical migraine susceptibility (Fisher's Combined P-value = 0.006) and indicate that further research into the role of the DBH gene in migraine aetiology is warranted. Nitric oxide (NO) is emerging as a key molecule affecting the pain associated with migraine. Since nitric oxide synthase (NOS) enzymes catalyse the synthesis of NO, the genes that code for these enzymes are good candidates for migraine molecular genetic analysis. This research involved investigating the role of a functionally relevant bi-allelic tetranucleotide polymorphism located in the promoter region of the human inducible nitric oxide synthase (iNOS) gene in migraine aetiology. A large group of migraine affected individuals were genotyped and compared to an age and sex matched group of unaffected controls. Results of a chi-squared analysis indicated that allele distributions for both migraine cases and controls were not significantly different (c2 = 1.93, P = 0.16). These findings offer no evidence for an allelic association of the tested iNOS polymorphism with the common forms of the disease and therefore do not support a role for this gene in migraine pathogenesis. In summary, this research involved linkage and association analysis of migraine candidate genes and genomic susceptibility regions. Whilst, the known FHM gene (CACNA1A) was excluded for significant involvement in typical migraine the adjacent INSR gene has been associated. Migraine is genetically heterogeneous and the results of this research also provide good evidence that the DBH gene is involved in disease predisposition, whilst the DRD2, SERT and INOS gene were not shown to be implicated. An additional susceptibility region for typical migraine is also likely to localise to chromosome 1q31. Overall, the results presented in this thesis have contributed valuable data to the understanding of the molecular genetics of migraine with and without aura. Future research into the molecular pathophysiological mechanisms of migraine will greatly facilitate the development of more effective diagnosis and treatment strategies.

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8

Knight, Yolanda Edna. "Midbrain periaqueductal grey modulation trigeminal nociception : relationship to migraine". Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.272390.

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9

Maude, Sophia Karen. "An investigation of genetic risk factors for migraine". Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248576.

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Migraine manifests itself episodically with incidence ranging from one attack in a lifetime to one almost every day. Most migraineurs suffer from typical migraine with or without aura, that is inherited in a complex manner. A small number of migraineurs suffer from FHM, a condition that exhibits Mendelian inheritance. BFNC is another rare episodic disorder that exhibits Mendelian inheritance. In a four generational family the BFNC phenotype was linked to the KCNQ2 gene on chromosome 20q13.3. Blood samples and epidemiological information were collected from 214 migraine probands in the Grampian region. An Access database was created to hold these data which were subsequently input. The database was utilised to extract epidemiological information about the cohort for subsequent analysis. These data were compared to other studies to characterise the severity of the cohort. A total of six polymorphisms were analysed by association analysis for involvement in migraine. The first polymorphism to be analysed was the -141C Ins/Del polymorphism in the DRD2 gene on chromosome 11q22. This polymorphism was analysed by restriction digest. Statistical analysis excluded this polymorphism and the regions encompassed by linkage disequilibrium in the aetiology of migraine. The second and third polymorphisms were located in intron 1 of the ERa gene on chromosome 6q25. These two polymorphisms were identified by restriction digest. Individual and haplotype analysis excluded the involvement of both polymorphisms in the aetiology of migraine. The fourth, fifth and sixth polymorphisms were located in exon 47, exon 23 and exon 8 of the CACNA1A gene on chromosome 19p13. The polymorphisms were analysed by capillary electrophoresis, restriction digest and DASH, respectively. All three polymorphisms were excluded from the aetiology of migraine. A total of 12 hot spot exons were sequenced in the CACNA1A gene in one individual afflicted by FHM and two by HM. No mutations were presented in the exons sequenced.

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10

Hunt, Megan. "Effectiveness of Pharmacological Treatments in Imploding vs. Exploding Headaches". Thesis, The University of Arizona, 2013. http://hdl.handle.net/10150/281156.

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A Thesis submitted to The University of Arizona College of Medicine - Phoenix in partial fulfillment of the requirements for the Degree of Doctor of Medicine.
Recent research shows variability in the effectiveness of botulinum toxin A among patients who experience their headaches as imploding compared with those who experience exploding headache sensations. Further research has not yet examined whether such variability exists among other pharmacological treatments. This study examines the effectiveness of acute and preventative medications in imploding vs. exploding headaches. 201 patients were recruited in the Women’s Health Internal Medicine Program at Mayo Clinic. These patients were given surveys to determine their physician identified headache type (imploding, exploding, or ocular), as well as patient-reported information about the effectiveness of prophylactic medications or triptans. This data was analyzed to determine whether a significant difference existed between medications that were effective for imploding, exploding, or ocular headaches. The study found that no such difference existed. The data was also used to analyze the correlation between physician-identified headache type and the patient-identified headache type. There appears to be only a weak correlation between these assignments, suggesting some room for improvement in the way headache directionality is explored by physician and understood by patients. In the future, research will hopefully uncover additional factors which are useful as predictors for migraine pharmacology.

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11

Anciano, D. "Psychological aspects of headache". Thesis, University of York, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356831.

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12

Sundholm, James, i n/a. "Analysis of Specific Migraine Candidate Genes Mapping to Human Chromosome 1". Griffith University. School of Health Science, 2003. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20030829.153348.

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Migraine, comprised of migraine with aura (MA) and migraine without aura (MO), is a painful neurovascular disease, affecting approximately 16% of the general population. It is characterised by a wide variety of symptoms including headache, nausea and vomiting, and photo- and phonophobia. The disorder is complex involving not only multiple genes, but also specific environmental factors, which can induce attacks in genetically predisposed individuals. Hyperhomocysteinaemia is a known risk factor for cerebrovascular, peripheral vascular and coronary heart disease. The Methylenetetrahydrofolate Reductase (MTHFR) enzyme is involved in homocysteine metabolism. Furthermore, it has been reported that a homozygous mutation (677C to T; Ala to Val) in the 5,10-MTHFR gene is associated with an elevation in plasma homocysteine levels (Frosst et al., 1995). This common mutation in the MTHFR gene has recently been associated with migraine with aura in a Japanese cohort (Kowa et al., 2000). The present study was designed to determine the prevalence of the MTHFR C677T mutation in Australian patients with migraine and to determine whether this mutation is associated with the disease in Caucasians. A large case-control study, consisting of 270 patients with migraine (167 with aura and 103 without aura), and 270 normal matched controls was investigated. Genotypic results indicated that the prevalence of the homozygous (T/T) genotype in migraine sufferers (15%) was higher than that of controls (9%) (P = 0.084). Furthermore, the frequency of the mutant (T/T) genotype in individuals with MA (19%) was significantly higher than in controls (9%) (P = 0.006). Interestingly, the risk of MA was ~2.5-fold higher in suffers possessing the homozygous variant (OR = 2.52, CI: 1.42 - 4.47, P = 0.0012). To confirm the MTHFR allelic association with MA, family-based tests were performed in an independent pedigrees group, where only those with MA were considered affected. Results from both the Pedigree Disequilibrium Test (PDT) and Family-Based Association Test (FBAT) analysis revealed slight, although not significant (PDT test, P = 132; and FBAT test, P = 0.390), over-transmission of the mutant allele (T) from parents to affected offspring. However, despite the MTHFR variant having a high heterozygosity (0.48), there were a limited number of informative transmissions for the MTHFR variant in the pedigree group resulting in reduced power for these tests. In conclusion, our results support the trends reported in the Japanese migraine study and suggest that the homozygous 677T gene variant causing mild hyperhomocysteinaemia, is a genetic risk factor for migraine, and indicate that further studies investigating the role of this gene are warranted. Mutations in various ion channel genes are responsible for neurovascular and other neurological disorders. Inherited ion channel mutations or "channelopathies" are increasingly found to be the cause of various neurological disorders in humans. Wittekindt and colleagues (1998) reported that the calcium-activated potassium channel (hKCa3) gene is a good candidate for schizophrenia and bipolar disorder (BD), as well as for other neurological disorders such as migraine. The hKCa3 gene is a neuronal small conductance calcium-activated potassium channel, which contains a polyglutamine tract, encoded by a polymorphic CAG repeat in the gene. The hKCa3 gene encodes a protein of 731 amino acids containing two adjacent polyglutamine sequences in its N-terminal domain separated by 25 amino acids. The C-terminal polyglutamine sequence is highly polymorphic in length (Austin et al., 1999). hKCa3 plays a critical role in determining the firing pattern of neurons via the generation of slow after-polarization pulses and the regulation of intracellular calcium channels (Kohler et al., 1996). Three distinct mutations in the a1 calcium channel gene have been shown to cause SCA-6, episodic ataxia-2 and familial hemiplegic migraine (FHM) (Ophoff et al., 1996). The hKCa3 gene contains a highly polymorphic CAG repeat that was initially mapped (Chandy et al., 1997) to a schizophrenia locus on chromosome 22 (Pulver et al., 1994). Recently Austin et al (1999) re-mapped hKCa3 and found it to reside on chromosome 1q21, a region that has been linked to FHM (Austin et al., 1999), a rare subtype of MA (Ducros et al., 1997; Gardner et al., 1998), and a region recently showing genetic linkage to typical migraine (Lea et al., 2002). The hKCa3 polymorphism results in small variations in polyglutamine number, similar to those that occur in the calcium channel a1a subunit gene (CACNA1A), which is encoded by CAG expansions and thought to cause Spinocerebellar Ataxia Type 6 via loss of channel function (Austin et al., 1999). Given the recent linkage of FHM to the region of chromosome 1q21, to which hKCa3 resides, and also linkage of typical migraine to this region, a large case-control study investigating this hKCa3 CAG marker and consisting of 270 migraine and 270 stringently matched healthy controls was undertaken. Our results indicated that there was no statistically significant difference in allele distributions for this marker between migraine and non-migraine patients (P >0.05). No significant difference in the allelic distribution was observed in the MA or MO groups when compared to controls (P >0.05) and there was no significant difference in CAG repeat length distribution between the migraine group and controls (P = 0.92), or between the MA and MO groups (P = 0.72) collectively. Hence, the CAG repeat in this gene does not show expansion in migraine. Overall, our results provide no genetic evidence to suggest that the hKCa3 CAG repeat polymorphism is involved in migraine aetiology in Australian Caucasians. Thus the involvement of the hKCa3 gene in migraine is not likely, although the hKCa3 gene remains an important candidate for other neurological disorders that may be linked to the 1q21.3 chromosomal region.

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13

Sundholm, James. "Analysis of Specific Migraine Candidate Genes Mapping to Human Chromosome 1". Thesis, Griffith University, 2003. http://hdl.handle.net/10072/367192.

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Migraine, comprised of migraine with aura (MA) and migraine without aura (MO), is a painful neurovascular disease, affecting approximately 16% of the general population. It is characterised by a wide variety of symptoms including headache, nausea and vomiting, and photo- and phonophobia. The disorder is complex involving not only multiple genes, but also specific environmental factors, which can induce attacks in genetically predisposed individuals. Hyperhomocysteinaemia is a known risk factor for cerebrovascular, peripheral vascular and coronary heart disease. The Methylenetetrahydrofolate Reductase (MTHFR) enzyme is involved in homocysteine metabolism. Furthermore, it has been reported that a homozygous mutation (677C to T; Ala to Val) in the 5,10-MTHFR gene is associated with an elevation in plasma homocysteine levels (Frosst et al., 1995). This common mutation in the MTHFR gene has recently been associated with migraine with aura in a Japanese cohort (Kowa et al., 2000). The present study was designed to determine the prevalence of the MTHFR C677T mutation in Australian patients with migraine and to determine whether this mutation is associated with the disease in Caucasians. A large case-control study, consisting of 270 patients with migraine (167 with aura and 103 without aura), and 270 normal matched controls was investigated. Genotypic results indicated that the prevalence of the homozygous (T/T) genotype in migraine sufferers (15%) was higher than that of controls (9%) (P = 0.084). Furthermore, the frequency of the mutant (T/T) genotype in individuals with MA (19%) was significantly higher than in controls (9%) (P = 0.006). Interestingly, the risk of MA was ~2.5-fold higher in suffers possessing the homozygous variant (OR = 2.52, CI: 1.42 - 4.47, P = 0.0012). To confirm the MTHFR allelic association with MA, family-based tests were performed in an independent pedigrees group, where only those with MA were considered affected. Results from both the Pedigree Disequilibrium Test (PDT) and Family-Based Association Test (FBAT) analysis revealed slight, although not significant (PDT test, P = 132; and FBAT test, P = 0.390), over-transmission of the mutant allele (T) from parents to affected offspring. However, despite the MTHFR variant having a high heterozygosity (0.48), there were a limited number of informative transmissions for the MTHFR variant in the pedigree group resulting in reduced power for these tests. In conclusion, our results support the trends reported in the Japanese migraine study and suggest that the homozygous 677T gene variant causing mild hyperhomocysteinaemia, is a genetic risk factor for migraine, and indicate that further studies investigating the role of this gene are warranted. Mutations in various ion channel genes are responsible for neurovascular and other neurological disorders. Inherited ion channel mutations or "channelopathies" are increasingly found to be the cause of various neurological disorders in humans. Wittekindt and colleagues (1998) reported that the calcium-activated potassium channel (hKCa3) gene is a good candidate for schizophrenia and bipolar disorder (BD), as well as for other neurological disorders such as migraine. The hKCa3 gene is a neuronal small conductance calcium-activated potassium channel, which contains a polyglutamine tract, encoded by a polymorphic CAG repeat in the gene. The hKCa3 gene encodes a protein of 731 amino acids containing two adjacent polyglutamine sequences in its N-terminal domain separated by 25 amino acids. The C-terminal polyglutamine sequence is highly polymorphic in length (Austin et al., 1999). hKCa3 plays a critical role in determining the firing pattern of neurons via the generation of slow after-polarization pulses and the regulation of intracellular calcium channels (Kohler et al., 1996). Three distinct mutations in the a1 calcium channel gene have been shown to cause SCA-6, episodic ataxia-2 and familial hemiplegic migraine (FHM) (Ophoff et al., 1996). The hKCa3 gene contains a highly polymorphic CAG repeat that was initially mapped (Chandy et al., 1997) to a schizophrenia locus on chromosome 22 (Pulver et al., 1994). Recently Austin et al (1999) re-mapped hKCa3 and found it to reside on chromosome 1q21, a region that has been linked to FHM (Austin et al., 1999), a rare subtype of MA (Ducros et al., 1997; Gardner et al., 1998), and a region recently showing genetic linkage to typical migraine (Lea et al., 2002). The hKCa3 polymorphism results in small variations in polyglutamine number, similar to those that occur in the calcium channel a1a subunit gene (CACNA1A), which is encoded by CAG expansions and thought to cause Spinocerebellar Ataxia Type 6 via loss of channel function (Austin et al., 1999). Given the recent linkage of FHM to the region of chromosome 1q21, to which hKCa3 resides, and also linkage of typical migraine to this region, a large case-control study investigating this hKCa3 CAG marker and consisting of 270 migraine and 270 stringently matched healthy controls was undertaken. Our results indicated that there was no statistically significant difference in allele distributions for this marker between migraine and non-migraine patients (P >0.05). No significant difference in the allelic distribution was observed in the MA or MO groups when compared to controls (P >0.05) and there was no significant difference in CAG repeat length distribution between the migraine group and controls (P = 0.92), or between the MA and MO groups (P = 0.72) collectively. Hence, the CAG repeat in this gene does not show expansion in migraine. Overall, our results provide no genetic evidence to suggest that the hKCa3 CAG repeat polymorphism is involved in migraine aetiology in Australian Caucasians. Thus the involvement of the hKCa3 gene in migraine is not likely, although the hKCa3 gene remains an important candidate for other neurological disorders that may be linked to the 1q21.3 chromosomal region.
Thesis (Masters)
Master of Philosophy (MPhil)
School of Health Sciences
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Sullivan, Daniel P. "Psychological Mechanisms, Interventions, and Clinical Outcomes in Sleep-Related Headaches". Thesis, Griffith University, 2022. http://hdl.handle.net/10072/417223.

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Sleep problems are one of the most frequent triggers of primary headaches such as migraine and tension-type headache, second only to stress. Whilst the relationship between various sleep disorders, and poor sleep in general has been well established, to date there has been a paucity of research examining psychological mechanisms of sleep-related headaches. This thesis sought to examine the following research questions about sleep-related headaches, in the context of the discipline of Clinical Psychology: Study One (Chapter Two) – What is causing the problem? What are the psychological mechanisms underpinning sleep-related headaches? Study Two (Chapter Three) – What are the consequences of the problem? Do insomnia, headaches and co-morbid insomnia and headaches predict poor therapeutic response to psychotherapy? Study Three (Chapter Four) – What can we do about the problem? Do psychological sleep interventions help both sleep and headaches? Chapter Five – What does the future hold? Exploring the next directions in sleep and headache research. Study One demonstrated that both maladaptive sleep beliefs and sleep safety behaviours are associated with greater headache frequency, mediated by sleep quality. This study also provided preliminary empirical support for sleep-related triggers in the Trigger Avoidance Model of Headaches. It was found that greater efforts to avoid both inadequate and excessive sleep, and fatigue and tiredness were associated with greater headache frequency, mediated by increased trigger sensitivity. Study Two demonstrated that in adults attending the Griffith University Psychology Clinic, the presence of frequent insomnia or headache symptoms at the initial session was highly predictive of an inadequate response to psychotherapy (remaining clinically symptomatic at the final session of therapy). This effect was found to be even more pronounced in those with both insomnia and headaches. Study Three was a systematic review and meta-analysis, which assessed the literature on the use of psychological sleep interventions for headaches. The review found only four studies which met criteria for inclusion. In pooling the three studies which were suitable for meta-analysis, a random-effects model demonstrated that psychological sleep interventions (such as Cognitive Behaviour Therapy for Insomnia) reduced the frequency, but overall, not the intensity of primary headaches. Given the small number of studies and overall patients included, this should not be considered a conclusive finding. Taken together, the findings of this thesis demonstrate both cognitive and behavioural factors are at play in sleep-related headaches, and that insomnia and headaches may blunt the therapeutic response to psychotherapy. Reassuringly, however, psychological sleep interventions are known to improve sleep, and this thesis found they also reduce headache frequency. This may mitigate some of the negative effects of sleep and headache problems on psychotherapeutic response. Future research directions (discussed in Chapters Five and Six) should examine the role of sleep behaviours in clinical samples of chronic migraine patients, and assess neurophysiologic markers of sleep-related headaches and subsequent response to therapy (such as EEG power spectrum and sleep architecture), and the pursuit of integrative and modular headache treatments tailored to co-occurring conditions/problems. The original contributions to knowledge from this thesis are the implication of maladaptive sleep beliefs in the sleep-headache relationship, that insomnia and headaches impair psychotherapeutic response – an effect which is additive when both occur, and the first systematic review and meta-analysis of psychological sleep interventions for headaches.
Thesis (Professional Doctorate)
Doctor of Philosophy in Clinical Psychology (PhD ClinPsych)
School of Applied Psychology
Griffith Health
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15

Melikian, Ana Rita Almeida. "Brief psychotherapy for management of primary headaches : a clinical grounded approach". Thesis, University of Sunderland, 2007. http://sure.sunderland.ac.uk/3780/.

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This research explores the potentialities of psychotherapy for the management of chronic pain. The model used is brief therapy of systemic orientation and the chronic pain managed is primary headaches (namely, migraines and tension-type headaches). In order to produce clinically relevant material, this research is carried out within an alternative research paradigm. The raw data are the audio-recordings of two cases: one with a man suffering from migraines; the other with a woman suffering from chronic tension-type headaches (aggravated by migraine episodes). These were selected from a pool of cases because they illustrate the phenomena under study and both completed a follow-up which confirmed an acceptable headache management outcome. The recordings were transcribed in order to be studied using discourse analysis of social constructionist orientation (DA hereafter). The research questions explored are: How were the headache problems, the therapeutic aims and the resources for managing them constructed during therapy? What did the participants do with these constructions? How was this particular type of talk interaction helpful in changing the way these two people managed their primary headaches? DA reveals that: (1) the headache problems are entangled in many vicious cycles, Catch-22 situations and even double-binds, and that these patterns have the tendency to perpetuate the problems; (2) the meaning of the headaches vary from one patient to the other, being greatly influenced by their personal experiences, family histories and interaction with health professionals; (3) these meanings influence the co-construction of the therapeutic aims, with management (rather than a cure) emerging as a more achievable goal, with additional auxiliary aims also becoming very important; (4) specific interventions for managing the headaches and for achieving the auxiliary aims lead to concrete changes; (5) these changes are sometimes generalized for other situations, and therapy is seen as a useful resource. Thus, this study shows some of the potentialities of brief therapy of systemic orientation to manage primary headaches, producing concrete suggestions that can be applied in clinical work.

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Clark, Susan Matthews. "Temperature Biofeedback and Visual Imagery in the Treatment of Migraine Headaches". Thesis, North Texas State University, 1985. https://digital.library.unt.edu/ark:/67531/metadc331412/.

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After an initial four week baseline period, during which headache activity and medication consumption were monitored, 28 migraineurs were randomly assigned to one of the following groups: (a) the biofeedback temperature warming group, (b) the visual imagery group, (c) the combined treatment group, or (d) the comparison group. All four groups continued to monitor their headache activity and medication consumption during the eight week treatment period and the eight week follow-up period. A two way analysis of variance computed on groups over time indicated a significant decrease in headache activity and medication consumption. During the follow-up period (a) the combined treatment group had significantly fewer headaches than the biofeedback group or the comparison group and (b) the visual imagery group and the combined treatment group had significantly fewer headache hours than the biofeedback group or the comparison group. These results do not appear to be attributable to differences between groups on the amount of time spent in home practice or subjective ratings of relaxation. There was no consistent relationship between increases in finger temperature and headache activity improvement. Decreases in powerful other scores, as measured by the Health Attribution Test, and increases in subjective ratings of internal control were consistent with a reduction in headache activity and medication consumption.

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Chiros, Christine E. "The Role of Acceptance in Appraisal and Coping with Migraine Headaches". Bowling Green State University / OhioLINK, 2007. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1189641256.

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Stewart, Kristi Lowe. "Pharmacological and Behavioral Treatments for Migraine Headaches: A Meta-Analytic Review". DigitalCommons@USU, 2004. https://digitalcommons.usu.edu/etd/6207.

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Migraine headache is a painful and often serious problem in the United States. There are many prophylactic pharmacological and nonpharmacological treatments available for migraine headaches. However, choosing between them can be difficult for individuals and treatment providers alike. The primary literature regarding the effectiveness of pharmacological and nonpharmacological treatments is quite dense. More than 191 primary studies were identified as providing information about the effectiveness of one or more treatments for migraine headaches. Of these, 82 articles were retained for meta-analyses on six prophylactic treatments for migraine: propranolol, flunarizine, divalproex sodium, thermal biofeedback, relaxation treatments, and combined treatments. These results suggest that all of the treatments examined have very similar treatment effect sizes. Effect sizes for the reduction of migraine were found to be between .60 and .75 for all treatments. Results suggest that selection of treatment for migraine must be based on more than treatment effectiveness rates alone.

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Lewis, Kristin N. "Pain Modulation in Tension-Type and Migraine Headaches: The Offset Analgesia Effect". Ohio University / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1412688879.

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Mahmud, Farina J. "Nitric Oxide and Peroxynitrite Imbalance Triggers Cortical Hyper-Excitability and Migraine Headaches". Ohio University / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1481716721296335.

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Atkinson, Michael Henry 1962. "Immune disease, headaches, and handedness in learning disabled and regular education students". Thesis, The University of Arizona, 1991. http://hdl.handle.net/10150/278020.

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The relationship of immune disease, headaches, and handedness to learning disabilities and attention deficit disorder (ADD) was investigated. Questionnaires were completed by the parents of learning disabled (LD) and regular education students attending public middle school. A measure of ADD was included to separate the sample of LD students into two categories: those with academic and behavior disorders and those with only academic disorders. Discriminant analyses failed to indicate a significant difference between the LD and regular education students on measures of immune disease, headaches, handedness, or attention deficit disorder. Chi-square analyses of the data indicated that the only significant difference between LD and regular education students was on a measure of allergies to food and drink where the LD students reported a higher incidence as compared to regular education students. Implications of these findings are discussed.

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22

Montalva, Roen. "The Effects of Massage Therapy on Tension-Type Headaches: A Placebo Controlled Trial". Ohio : Ohio University, 2006. http://www.ohiolink.edu/etd/view.cgi?ohiou1157734709.

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Wisniewski, Jack J. "Relaxation therapy, treatment compliance, and psychological variables in the treatment of childhood headaches /". The Ohio State University, 1987. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487335992904848.

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Friedman, Lauren E., Bizu Gelaye, Sixto E. Sanchez, B. Lee Peterlin, Michelle A. Williams i Marta B. Rondón. "Association of Migraine Headaches With Suicidal Ideation Among Pregnant Women in Lima, Peru". American Headache Society, 2016. http://hdl.handle.net/10757/609583.

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BACKGROUND: Suicide is a leading cause of maternal death globally, and suicide prevalence rates have been shown to be increased in those with migraine. No previous study has examined the association between migraine and suicidal ideation during pregnancy. OBJECTIVE: To examine the association between migraine and suicidal ideation among a cohort of pregnant women. METHODS: A cross-sectional study was conducted among 3372 pregnant women attending prenatal care clinics in Lima, Peru. Suicidal ideation and depression were assessed using the Patient Health Questionnaire-9 (PHQ-9) scale during early pregnancy. Migraine classification (including migraine and probable migraine) was based on International Classification of Headache Disorders-III beta criteria. Multivariable logistic regression analyses were performed to estimate odds ratios (OR) and 95% confidence intervals (95%CI). RESULTS: Suicidal ideation was more common among those with migraine (25.6%) as compared to those with probable migraine (22.1%, P < .001) or non-migraineurs (12.3%, P < .001). After adjusting for confounders, including depression, those with migraine or probable migraine had a 78% increased odds of suicidal ideation (OR = 1.78; 95% CI: 1.46-2.17), as compared with non-migraineurs. Women with both migraine and depression had a 4.14-fold increased odds of suicidal ideation (OR = 4.14; 95% CI: 3.17-5.42) compared to those with neither condition. CONCLUSION: Migraine is associated with increased odds of suicidal ideation in pregnant women even when controlling for depression. These findings support the consideration of screening women with comorbid migraine and depression for suicidal behavior during pregnancy.
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25

Lima, Marcia Maria Ferreira. "Análise crítica dos critérios diagnósticos da Sociedade Internacional de Cefaléia (SIC - 1988 e SIC - 2003), das cefaléias na infância e na adolescência /". Botucatu : [s.n.], 2003. http://hdl.handle.net/11449/87355.

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Orientador: Marcos Augusto de Moraes Silva
Resumo: Analisar criticamente os critérios de diagnósticos das cefaléias da Sociedade Internacional de Cefaléia (SIC) 1988 e da SIC 2004. Método: Foram analisados retrospectivamente 496 pacientes atendidos no ambulatório de Cefaléia na Infância e Adolescência do HC Unesp Botucatu no período de 1992 à 2002. Empregou-se critério diagnóstico clínico intuitivo (CDI) como padrão "gold standard". A comparação entre CDI, SIC 88 e Proposta SIC 2002 foi realizada utilizando-se as variáveis: Sensibilidade, Especificidade (E), Valor Preditivo, Positivo (VPP), Valor Preditivo Negativo (VPN); segundo as fórmulas/critérios: CLAP - OPS/OMS, 1988 e de Rouquayrol, 1993. Resultado: Observamos que a proposta SIC 2002 demonstrou maior sensibilidade com relação às migrâneas: a) sem aura, b) com aura, c) com aura típica, d) basilar. A proposta SIC 2002 apresenta alta especificidade. Não houve diferença significativa com as outras variáveis. Conclusões: A proposta SIC 2002 mostrou maior sensibilidade para as migrâneas quando comparada com a SIC 88. Possivelmente o fator tempo de duração das crises de cefaléia,diferentes entre ambas poderiam justificar a relativa baixa sensibilidade quando comparadas ao "gold standard".
Abstract: Critically analyse the diagnostic criteria of headaches from International Classification of Headache Disorders Diagnostic Criteria (ICHD) 1988 and from ICHD 2004. Method: Four hundred ninety-six patients who were attended at the Headache Outpatient Ward for Children and Adolescence of the General Hospital, Medical School of the State University from São Paulo - Unesp- of the city Botucatu from 1992 to 2002 were analyzed. Individuals were classified according three diagnostics groups: Intuitive Clinic Diagnostic (ICD-"gold standard"), ICHD I- 1988 and ICHD II-2004. They were statistically compared using the variables: Sensibility (S), Specificity (Sp), Positive Predictive Value (PPV), Negative Predictive Value (NPV), according to formulas/criteria: CLAP - PAHO/WHO (1988) and of Rouquayrol (1993). Result: It was observed that the ICHD II-2004 presented higher sensibility than ICHD I-1988 concerning migraine with and without aura, there was no significant difference concerning other variables. Conclusions: The ICHD II-2004 showed higher sensibility referring to migraine when compared with ICHD I 1988 without affecting specificity and although it improved migraine diagnosis in children and adolescents, the sensitivity remains poor.
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Stinson, Jill D. "Innovations in Integrating DSK: Fewer Courses, Fewer Headaches. Curricular Innovations and Science of Training". Digital Commons @ East Tennessee State University, 2019. https://dc.etsu.edu/etsu-works/7892.

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Rosdahl, Dana Rae Lillestol. "The effect of mindfulness meditation on tension headaches and secretory immunoglobulin A in saliva". Diss., The University of Arizona, 2003. http://hdl.handle.net/10150/290014.

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Chronic stress exerts a damaging influence on the physiology of the body and on a person's well-being. There is growing interest in nonpharmacologic interventions to address stress-related health problems, such as tension headaches, the focus of this research. Four research questions were examined: (1) Are there differences in the six study variables (perceived stress, time pressure, spiritual practices, sIgA, and tension headache intensity and duration) between the intervention and comparison groups? (2) What combination of variables best explains sIgA and tension headache intensity and duration? (3) Do spiritual practices function as a mediator of relationships between the psychological variables, sIgA, and headache intensity and duration? (4) How do group, gender, payment, and religious background affect changes in headache intensity and duration over time? A mixed pre-/post-experimental design with pre-/post-longitudinal measurements was used to examine the questions. The sample consisted of 50 women and 14 men with tension headaches, aged 18-70; 34 were randomly assigned to an intervention group and 30 to a comparison group. Intervention participants received an 8-week mindfulness meditation class, 2 hours a week. Comparison participants received an 8-week educational class in headaches, 1½; hours a week. Pre- and post-testing measurements were obtained on study variables and headache intensity and duration, as noted in diaries. Analysis results, using ANCOVA, multiple regression, and growth curve analysis, indicated that (1) the intervention group had a significantly higher post-treatment sIgA level than the comparison group; (2) in the combined groups, 14% of the total variance in sIgA, and 25% of the total in headache intensity post-test was explained by their pre-test scores; 62% of the explained variance in headache duration post-test was explained by its pre-test, sIgA pre-test, and stress post-test; (3) spiritual practices did not function as a mediator within the proposed model; (4) group, gender, payment, or religious background did not relate to a significant decrease in headache symptoms in either group. The intervention of mindfulness meditation affected an increase in sIgA level, had a near significant effect on spiritual practices over time, and did not cause significant changes in perceived stress or time pressure.

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Spickard, Brad. "Pain-Related Fear and Cognitive Performance in Recurrent Headache". Ohio University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=ohiou1312467205.

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Vernon, Howard. "Manual therapy of headaches of spinal origin : an investigation of etiology, mechanisms, diagnosis and treatment". Thesis, University of South Wales, 2003. https://pure.southwales.ac.uk/en/studentthesis/manual-therapy-of-headaches-of-spinal-origin(62c54f22-8e9d-4e49-b2b1-b2b7193d2223).html.

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This thesis has proposed the following: "that mechanical disorders of the upper cervical spine are an important cause of headaches". Four hypotheses were developed to investigate this thesis. 1. Upper cervical spine dysfunction plays an important role in headache etiology. 2. The importance of this role is more or less, depending on the type of headache. 3. Cervical dysfunction can be assessed and characterized by a range of standard clinical methodologies employed in manual therapy. 4. The cervical dysfunction involved in these types of headaches is treatable by spinal manipulative therapy and this results in clinical benefit for patients with these conditions. Four areas of evidence from my published work have been summarized to support this thesis. A. An anaesthetized animal model of upper cervical deep somatic inflammation has provided pathophysiologic responses which could be the origins of headaches of cervical origin, particularly the type currently known as "cervicogenic headache". B. Clinical descriptions have been redefined to reveal common features which could be grouped together and attributed to pathologies or dysfunctions in the regions investigated in the animal model. C. A new form of questionnaire was developed which produced evidence of an association between headache and neck pathology or dysfunction. D. An extensive literature review revealed reported associations between headache and neck pathology in diverse works, particularly those involving manual assessment and therapeutic procedures in the cervical spine. The evidence from such diverse sources strongly supports the hypotheses developed here and my thesis, that mechanical disorders of the upper cervical spine are an important cause of headache.

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30

Arango, Manuel A. (Manuel Antonio) Carleton University Dissertation Psychology. "The Role of compliance, hypnotic imagery, and nonhypnotic imagery in the treatment of recurrent headaches". Ottawa, 1991.

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Whitney, Patrick F. "Patient Reported Efficacy of Botulinum Toxin Type A in the Treatment of Chronic Migraine Headaches". Scholar Commons, 2010. https://scholarcommons.usf.edu/etd/1806.

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Objective: To assess patient reported efficacy of Botulinum toxin type-A for the prophylaxis of migraine headaches in patients with frequent migraine headaches prior to initiation of treatment with Botulinum toxin type-A compared to post treatment. Questions addressed include is there a difference in frequency of migraine headaches following treatment with Botulinum toxin type-A, is there a difference in cost of conventional treatment versus Botulinum toxin type-A and is there a difference in quality of life. Research Plan: Questions addressed patient status prior to the initiation of treatment as well as post treatment. Patient quality of life change, duration and frequency headache improvement are the primary focus. Other considerations included the cost difference between the previous use of other treatment and the periodic treatment with Botulinum toxin type-A. Methodology: A Cross Sectional study utilizing a questionnaire consisting of a modified Migraine Disability Assessment (MIDAS) questionnaire will be given to patients who had received more than one series of injections. Patients who reported chronic migraine headaches and were refractory to previous treatment methods were screened and placed in programs utilizing intramuscular injection of Botulinum toxin type-A at standard points on the face, Temporalis muscle and paracervical muscles. Clinical Relevance: This assessment is relevant to occupational issues due to the increasing number of patients applying for disability due to uncontrolled migraine headaches as well as lost productivity and reduction in functional capacity for activities of daily living. Impact and Significance: Patients that are debilitated by recurrent chronic migraine headaches suffer loss of productive time at work and home. Treatment with Botulinum toxin type-A may results in significant relief allowing fewer days lost at work and improved quality of life. There may be significant cost saving if treatment results in discontinuation of other medications previously used for treatment of migraine headaches. Findings: According to the patients' responses to this survey, it appears that there was an overall improvement in the patients' ability to do work, for those who were employed, as well as their ability to do activities of daily living post treatment with Botulinum toxin-A. Though there were occasionally conflicting data seen in individual cases regarding responses to some of the answers, there appeared to be an overall statistically significant reduction in the mean of responses to the questions. The general implication is consistent with studies that indicate Botulinum toxin-A may be a useful adjunct in the prophylactic treatment of refractory migraine headaches.

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32

Peden, Andrew David. "Recurrent paediatric headaches : individual and contextual factors, progressive relaxation, and the development of an ecological model". Thesis, Manchester Metropolitan University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.342007.

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33

Lima, Márcia Maria Ferreira [UNESP]. "Análise crítica dos critérios diagnósticos da Sociedade Internacional de Cefaléia (SIC - 1988 e SIC - 2003), das cefaléias na infância e na adolescência". Universidade Estadual Paulista (UNESP), 2003. http://hdl.handle.net/11449/87355.

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Made available in DSpace on 2014-06-11T19:22:50Z (GMT). No. of bitstreams: 0 Previous issue date: 2003Bitstream added on 2014-06-13T18:49:44Z : No. of bitstreams: 1 lima_mmf_me_botfm.pdf: 693398 bytes, checksum: 8736cc7b15cffbd6313959a53f1a78b3 (MD5)
Fundação para o Desenvolvimento Médico e Hospitalar (Famesp)
Analisar criticamente os critérios de diagnósticos das cefaléias da Sociedade Internacional de Cefaléia (SIC) 1988 e da SIC 2004. Método: Foram analisados retrospectivamente 496 pacientes atendidos no ambulatório de Cefaléia na Infância e Adolescência do HC Unesp Botucatu no período de 1992 à 2002. Empregou-se critério diagnóstico clínico intuitivo (CDI) como padrão “gold standard”. A comparação entre CDI, SIC 88 e Proposta SIC 2002 foi realizada utilizando-se as variáveis: Sensibilidade, Especificidade (E), Valor Preditivo, Positivo (VPP), Valor Preditivo Negativo (VPN); segundo as fórmulas/critérios: CLAP – OPS/OMS, 1988 e de Rouquayrol, 1993. Resultado: Observamos que a proposta SIC 2002 demonstrou maior sensibilidade com relação às migrâneas: a) sem aura, b) com aura, c) com aura típica, d) basilar. A proposta SIC 2002 apresenta alta especificidade. Não houve diferença significativa com as outras variáveis. Conclusões: A proposta SIC 2002 mostrou maior sensibilidade para as migrâneas quando comparada com a SIC 88. Possivelmente o fator tempo de duração das crises de cefaléia,diferentes entre ambas poderiam justificar a relativa baixa sensibilidade quando comparadas ao “gold standard”.
Critically analyse the diagnostic criteria of headaches from International Classification of Headache Disorders Diagnostic Criteria (ICHD) 1988 and from ICHD 2004. Method: Four hundred ninety-six patients who were attended at the Headache Outpatient Ward for Children and Adolescence of the General Hospital, Medical School of the State University from São Paulo – Unesp- of the city Botucatu from 1992 to 2002 were analyzed. Individuals were classified according three diagnostics groups: Intuitive Clinic Diagnostic (ICD-“gold standard”), ICHD I- 1988 and ICHD II-2004. They were statistically compared using the variables: Sensibility (S), Specificity (Sp), Positive Predictive Value (PPV), Negative Predictive Value (NPV), according to formulas/criteria: CLAP – PAHO/WHO (1988) and of Rouquayrol (1993). Result: It was observed that the ICHD II-2004 presented higher sensibility than ICHD I-1988 concerning migraine with and without aura, there was no significant difference concerning other variables. Conclusions: The ICHD II-2004 showed higher sensibility referring to migraine when compared with ICHD I 1988 without affecting specificity and although it improved migraine diagnosis in children and adolescents, the sensitivity remains poor.

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Brogley, Webb Jordan. "Concussions and Other Headaches: An Analysis of the Journalistic Coverage of the Concussion Crisis and Football-Related Brain Trauma". Ohio University Honors Tutorial College / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1401454355.

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Gabert-Quillen, Crystal A. "The Efficacy of Written Emotional Expression at Reducing Back and Headache Pain in College Students". Kent State University / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=kent1340909581.

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Hunter, Rebekka, i David Rouff. "A Cost-Effectiveness Analysis of Amitriptyline, Divalproex, Propranolol, and Topiramate in the Prophylaxis of Migraine Headaches Based on Published Clinical Trials". The University of Arizona, 2007. http://hdl.handle.net/10150/624402.

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Class of 2007 Abstract
Objectives: To compare the cost-effectiveness of amitriptyline, divalproex, propranolol, and topiramate in the prophylactic treatment of migraine headaches based on published data. Methods: A MEDLINE search was done to identify all randomized, controlled clinical trials evaluating the efficacy of amitriptyline, divalproex, propranolol, and topiramate in the prophylactic treatment of migraine headaches. Results from these studies were then combined with drug cost and health care service costs related to treatment failure and adverse events to assess the relative cost-effectiveness of each medication. A decision tree model was created and Monte Carlo simulation was done to determine each products cost-effectiveness. Results: Amitriptyline was both most effective and least costly of the four treatment regimens studied. The mean costs for a 90 day treatment of each of the four respective medications were found to be: amitriptyline $62, divalproex $450, propranolol $91, and topiramate $802. An acceptability curve demonstrated that amitriptyline was most cost-effective 90% of the time, propranolol 10% of the time, and divalproex and topiramate were never the most cost-effective treatment. Conclusions: Among the most common medications used for migraine prophylaxis are amitriptyline, divalproex, propranolol, and topiramate. Based upon this analysis, amitriptyline was found to be the most cost-effective medication. Therefore, it is logical from the perspective of a managed-care organization to recommend amitriptyline as a first-line agent for migraine prophylaxis.

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Gonçalves, Daniela Aparecida de Godoi. "Estudos sobre a relação entre disfunção temporomandibular e cefaléia primária: avaliações populacional e clínica /". Araraquara : [s.n.], 2009. http://hdl.handle.net/11449/105481.

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Orientador: Cinara Maria Camparis
Banca: Marcelo Eduardo Bigal
Banca: José Geraldo Speciali
Banca: Mirian Aparecida Onofre
Banca: Francisco de Assis Mollo Júnior
Resumo: Cefaléia é uma experiência humana universal e pode representar a expressão final de uma ampla variedade de agressões ao sistema nervoso humano. Disfunção temporomandibular (DTM) refere-se a um conjunto de condições caracterizadas por dor na articulação temporomandibular (ATM), na área periauricular ou nos músculos da mastigação, sons articulares e desvios ou restrições dos movimentos mandibulares. Sindromicamente representa a consequência de várias disfunções no sistema mastigatório. Cefaleias são sintomas comuns entre indivíduos com DTM. Além de serem prevalentes e potencialmente incapacitantes, evidências limitadas também sugerem que tipos específicos de cefaleias e DTM são condições comórbidas. Os objetivos globais dos estudos aqui apresentados foram testar se há associação entre DTM e cefaléias primárias, se existe especificidade nessa associação e finalmente se há diferença na magnitude da associação de acordo com subtipos de DTM e classificação das cefaléias primárias. Os estudos foram conduzidos em duas amostras distintas, sendo uma populacional e a outra clínica. Os dados do estudo populacional foram coletados por meio de dois questionários aplicados durante ligações telefônicas. Um deles abordava as características das cefaleias e baseava-se nos critérios da Sociedade Internacional de Cefaleias. O outro questionava a existência de sintomas relacionados às DTMs. No estudo clínico, o mesmo questionário foi usado para coletar informações sobre as cefaleias, e as DTMs foram classificadas por meio da aplicação do Critérios Diagnósticos de Pesquisa em Disfunção Temporomandibular (RDC/TMD). Concluiu-se que, em ambas as amostras, as DTMs são mais comuns entre indivíduos... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: Headache is a nearly universal human experience, and may represent the final common expression of a wide variety of assaults upon the human nervous system. TMD refers to a group of conditions characterized by pain in the temporomandibular joint (TMJ), in the preauricular area or muscles of mastication, TMJ sounds, and by deviations or restriction in mandibular range of motion. Syndromically represents the consequences of several disorders into the masticatory system. Headaches have been seen as a common symptom among individuals with TMD. Beyond being prevalent and disabling disorders, limited evidence also suggest that specific headache disorders and TMD are comorbid. Controversies regarding this relation include the specificity of the association and the influence of severity of one on the other. The aims of the studies here presented were explore the relation between primary headaches and TMD focusing on prevalence of both in a populational sample, as well as to clarify the relation between TMD sub-types and TMD chronic pain severity on diagnostic and frequency of primary headaches. Sudies were conducted on two different samples, one of them a populational sample and the other a clinical sample. Data from the populational study was collected using two different questionnaires about TMD symptoms and headache features, based on International Headache Society criterias, applied by means a telephone call. On clinical study data related to headache was collected using the sample questionnaire, and TMD was classified using the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). It was found that TMD symptoms are more common in migraine, episodic tension-type headache (ETTH) and chronic daily headache (CDH) relative to individuals without headache in both samples. Magnitude of association is higher... (Complete abstract click electronic access below)
Doutor

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Richardson, Gwendolen M. "Cognitive-behavioral therapy for the treatment of headaches diagnosed as common migraine a minimal-therapist-contact approach versus a clinic-based approach". Thesis, University of Ottawa (Canada), 1988. http://hdl.handle.net/10393/5115.

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Alva-Urcia, Carlos, Miguel Angel Aguilar-Luis, Carlos Palomares-Reyes, Wilmer Silva-Caso, Luis Suarez-Ognio, Pablo Weilg, Carlos Manrique, Fernando Vasquez-Achaya, Valle Luis J. del i Valle-Mendoza Juana del. "Emerging and reemerging arboviruses: A new threat in Eastern Peru". Public Library of Science (PLoS), 2017. http://hdl.handle.net/10757/622421.

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Background Arboviral diseases are one of the most common causes of acute febrile illness (AFI) and a significant health problem in South America. In Peru, laboratory etiologic identification of these infections occurs in less than 50% of cases, leading to underdiagnoses of important emerging arboviruses. Aim To assess the prevalence of the Dengue (DENV), Oropouche (OROV), Chikungunya (CHIKV), Mayaro (MAYV) and Zika (ZIKV) viruses in patients with acute febrile illness from Puerto Maldonado (Peru). Methodology Serum samples were obtained from patients with AFI during January 2016 to March 2016. A total of 139 specimens were analyzed for the presence of DENV, OROV, CHIKV, MAYV, and ZIKV using polymerase chain reaction (PCR). Results CHIKV in 9.4% and OROV in 8.6% were the most prevalent arboviruses, followed by DENV and ZIKV, with a prevalence of 6.5% and 5%, respectively. Among all patients, the most common symptoms accompanying fever were headaches 79.9%, muscle pain 65.5% and joint pain 63.3%. Conclusions During this short 3-month period, 4 arboviruses were detected by PCR, CHIKV and OROV being the most common arboviruses in Puerto Maldonado (Peru). Thus, it is crucial to include OROV detection in the national health surveillance. Furthermore, the etiologic clinical diagnosis of arboviral infections is not possible due to the low specificity of symptoms; therefore an increase of cases confirmed by molecular diagnostic methods will enhance arboviral surveillance in Peru.

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Sardas, Isabela. "Cultural Differences in Pain Experience and Behavior among Mexican, Mexican American and Anglo American Headache Pain Sufferers". Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc279369/.

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Review of previous research on cultural differences in pain experience and/or pain behavior revealed that cultural affiliation affects pain perception and response. Unfortunately, the many inconsistent findings in the literature on cultural differences in pain experience and behavior have made interpretations and comparisons of results problematic. These inconsistent findings could be attributed to variations in acculturation level among cultural groups. The purpose of this study was to investigate cultural differences in pain experience (assessed by McGill Pain Questionnaire, the Box Scale, the Headache Pain Drawing, and the Headache Questionnaire) and pain behavior (measured by determining medication use and interference of daily functioning due to headaches) among Mexican (n = 43), Mexican American (n = 36), and Anglo American (n = 50) female chronic headache pain sufferers. The contribution of acculturation to differences in pain experience and behavior among cultural groups was measured by the Acculturation Rating Scale for Mexican Americans. The three cultural groups of women significantly differed on pain experience and pain behavior. Specifically, Mexican women experienced their headache pain more intensely, severely, and emotionally than Mexican American and Anglo American women. Furthermore, Mexican women were more willing to verbally express their pain than the other two groups. As for pain behavior, Mexican women took more medication and reported more severe inhibition of daily activities due to headaches than Mexican American and Anglo American women. Ethnic identity, ethnic pride, and language preference were factors in the acculturation process which contributed the most to women's chronic pain experience and behavior. The greatest variability occurred within the Mexican American group of women who perceived themselves as being more Mexican in attitudes and/or behaviors, but more similar to Anglo American in their pain experience and pain behavior. Results are explained using biocultural multidimensional pain theory, social learning theory, and acculturation theory.

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SILVA-NÉTO, Raimundo Pereira da. "Modelo experimental de diferenciação por odores entre migrânea e outras cefaleias primárias". Universidade Federal de Pernambuco, 2016. https://repositorio.ufpe.br/handle/123456789/18022.

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Cefaleias primárias são decorrentes de disfunção cerebral e incluem migrânea, cefaleia do tipo tensional, cefaleias trigêmino-autonômicas e outras. Diversos fatores podem desencadear crises de cefaleia, mas os odores, especialmente o perfume, estão associados à migrânea. Objetivos: Caracterizar a estimulação olfatória como fator desencadeante de crises de cefaleia e de diferenciação entre migrânea e outras cefaleias primárias. Sujeitos e Métodos: O estudo foi prospectivo, experimental, randomizado com comparação de grupos, realizado no período de março a junho de 2015. Foram convidados 158 voluntários (73 homens e 85 mulheres) diagnosticados com cefaleias primárias, de acordo com os critérios da International Classification of Headache Disorders, Third Edition (beta version) (ICHD-3β). O estudo foi realizado por dois examinadores; atribuiu-se ao primeiro, diagnosticar a presença e o tipo de cefaleia primária, enquanto o segundo foi responsável pela exposição dos voluntários ao odor e pelo registro dos efeitos dessa exposição. Resultados: Dos 158 voluntários com cefaleia, houve 72 (45,6%) casos de migrânea e 86 (54,4%) com outras cefaleias primárias. Dos 72 migranosos, 53 (73,6%) eram mulheres e 19 (26,4%), homens e dos 86 casos de outras cefaleias primárias, 32 (37,2%) eram mulheres e 54 (62,8%), homens. A idade dos voluntários com migrânea e com outras cefaleias primárias foi, respectivamente, 22,5±3,10 e 22,9±3,10 anos. Essas diferenças não foram significantes (tmédias=0,666; p=0,566). Nos dois grupos, houve diferença nas características da cefaleia (c2=4,132; p=0,046). O odor desencadeou cefaleia (25/72; 34,7%) e náusea (5/72; 6,9%) apenas nos voluntários com migrânea, correspondendo a 19,0% (30/158) da amostra e em nenhum com outras cefaleias primárias (χ²=43,78; p<0,001). A cefaleia ocorreu mais frequentemente associada à náusea (p=0,146) e de localização bilateral (p=0,002) nos migranosos que apresentaram cefaleia desencadeada por odor. A cefaleia foi desencadeada após 118,0±24,6 min e a náusea após 72,8±84,7 min da exposição ao odor. Conclusões: O odor desencadeou crises de cefaleia ou náusea apenas nos pacientes com migrânea. Portanto, cefaleia desencadeada por odores poderá ser considerada um fator de diferenciação entre migrânea e outras cefaleias primárias e esse gatilho parece muito específico da migrânea.
Primary headaches are due to brain dysfunction and include migraine, tension-type headache, trigeminal autonomic cephalalgias and others. Several factors can trigger headache attacks, but odors, especially perfume, are associated with migraine. Objectives: To characterize the olfactory stimulation as a trigger of headaches and differentiation of crises between migraine and other primary headaches. Subjects and Method: The study was prospective, experimental, randomized with comparison of groups and conducted from March to June 2015. One hundred fifty-eight volunteers (73 men and 85 women) were diagnosed with primary headaches, according to criteria of the International Classification of Headache Disorders, third edition (beta version) (ICHD-3β). The study was conducted by two examiners and assigned to the first to diagnose the presence and type of primary headache, while the second was responsible for exposing the volunteers to odor and the recording the effects of this exposure. Results: Of the 158 volunteers with headache, there were 72 (45.6%) cases of migraine and 86 (54.4%) with other primary headaches. Of the 72 migraineurs, 53 (73.6%) were female and 19 (26.4%) male and 86 cases of other primary headaches, 32 (37.2%) were female and 54 (62.8%) male. The age of subjects with migraine and other primary headache was, respectively, 22.5 ± 3.10 and 22.9 ± 3.10 years. These differences were not significant (tmean=0.666; p=0.566). In both groups, there were differences in headache characteristics (c2=4.132; p=0.046). Headache attacks (25/72; 34.7%) and nausea (5/72; 6.9%) were triggered only in subjects with migraine, corresponding to 19.0% (30/158) of the sample, but in no with other primary headaches (χ²=43.78; p<0.001). Headache occurred more often associated with nausea (p=0.146) and bilateral location (p=0.002) in migraineurs who had headache triggered by odor. Headache was triggered after 118.0±24.6 min and nausea after 72.8±84.7 min of exposure to odor. Conclusions: The odor triggered headache attacks or nausea only in migraineurs. Therefore, headache triggered by odors may be considered a factor of differentiation between migraine and other primary headaches and this trigger seems very specific of migraine.

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Gasparini, Claudia Francesca. "Identification of Migraine Susceptibility Genes: Candidate Gene Studies". Thesis, Griffith University, 2014. http://hdl.handle.net/10072/367879.

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Migraine is a serious neurological disorder that affects the central nervous system causing painful attacks of headache. Attacks of head pain vary widely in intensity, frequency and duration lasting from anywhere between 4-72 hours and are often accompanied by further symptoms of nausea, vomiting, photo- and phonophobia. In 1988, a group of world leaders in the diagnosis of migraine formed the International Headache Society (IHS) and compiled and published a consensus set of diagnostic criteria known as International Classification of Headache Disorders, ICHD-I 1988. This was the first classification system and was subsequently updated in 2004, ICHD-II 2004 and more recently a 3rd Edition beta version has been released (ICHD-3rd Ed Beta Version) and is the gold standard for diagnosing headache disorders. Migraine displays two main subtypes termed migraine with or without aura (MA and MO respectively). The two forms are distinguished from each other based on the development of aura, a period of variable and diverse neurological symptoms that precede the headache phase.
Thesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Medical Science
Science, Environment, Engineering and Technology
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Gonçalves, Daniela Aparecida de Godoi [UNESP]. "Estudos sobre a relação entre disfunção temporomandibular e cefaléia primária: avaliações populacional e clínica". Universidade Estadual Paulista (UNESP), 2009. http://hdl.handle.net/11449/105481.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Cefaléia é uma experiência humana universal e pode representar a expressão final de uma ampla variedade de agressões ao sistema nervoso humano. Disfunção temporomandibular (DTM) refere-se a um conjunto de condições caracterizadas por dor na articulação temporomandibular (ATM), na área periauricular ou nos músculos da mastigação, sons articulares e desvios ou restrições dos movimentos mandibulares. Sindromicamente representa a consequência de várias disfunções no sistema mastigatório. Cefaleias são sintomas comuns entre indivíduos com DTM. Além de serem prevalentes e potencialmente incapacitantes, evidências limitadas também sugerem que tipos específicos de cefaleias e DTM são condições comórbidas. Os objetivos globais dos estudos aqui apresentados foram testar se há associação entre DTM e cefaléias primárias, se existe especificidade nessa associação e finalmente se há diferença na magnitude da associação de acordo com subtipos de DTM e classificação das cefaléias primárias. Os estudos foram conduzidos em duas amostras distintas, sendo uma populacional e a outra clínica. Os dados do estudo populacional foram coletados por meio de dois questionários aplicados durante ligações telefônicas. Um deles abordava as características das cefaleias e baseava-se nos critérios da Sociedade Internacional de Cefaleias. O outro questionava a existência de sintomas relacionados às DTMs. No estudo clínico, o mesmo questionário foi usado para coletar informações sobre as cefaleias, e as DTMs foram classificadas por meio da aplicação do Critérios Diagnósticos de Pesquisa em Disfunção Temporomandibular (RDC/TMD). Concluiu-se que, em ambas as amostras, as DTMs são mais comuns entre indivíduos...
Headache is a nearly universal human experience, and may represent the final common expression of a wide variety of assaults upon the human nervous system. TMD refers to a group of conditions characterized by pain in the temporomandibular joint (TMJ), in the preauricular area or muscles of mastication, TMJ sounds, and by deviations or restriction in mandibular range of motion. Syndromically represents the consequences of several disorders into the masticatory system. Headaches have been seen as a common symptom among individuals with TMD. Beyond being prevalent and disabling disorders, limited evidence also suggest that specific headache disorders and TMD are comorbid. Controversies regarding this relation include the specificity of the association and the influence of severity of one on the other. The aims of the studies here presented were explore the relation between primary headaches and TMD focusing on prevalence of both in a populational sample, as well as to clarify the relation between TMD sub-types and TMD chronic pain severity on diagnostic and frequency of primary headaches. Sudies were conducted on two different samples, one of them a populational sample and the other a clinical sample. Data from the populational study was collected using two different questionnaires about TMD symptoms and headache features, based on International Headache Society criterias, applied by means a telephone call. On clinical study data related to headache was collected using the sample questionnaire, and TMD was classified using the Research Diagnostic Criteria for Temporomandibular Disorders (RDC/TMD). It was found that TMD symptoms are more common in migraine, episodic tension-type headache (ETTH) and chronic daily headache (CDH) relative to individuals without headache in both samples. Magnitude of association is higher... (Complete abstract click electronic access below)

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Galdino, Gilma Serra. "MIGRÂNEAS E CEFALÉIA DO TIPO TENSIONAL CRÔNICA: ABORDAGEM DIAGNÓSTICA POR MÉDICOS NÃO-NEUROLOGISTAS". Universidade Estadual da Paraíba, 2006. http://tede.bc.uepb.edu.br/tede/jspui/handle/tede/1787.

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Doctors belonging to a Medical Services Cooperative in Campina Grande were interviewed with the objective to determine their diagnostic accuracy when faced with clinical cases of primary headache, and also to appreciate the amplitude of their knowledge about headache classification and procedures concerning exams prescriptions and therapeutic indications. Methodology. The method of extensive direct observation through the application of a questionnaire was used. The doctors were presented with three fictitious clinical histories which represented situations of frequent primary migraines such as: migraine with aura (MA), migraine without aura (MO) and chronic tensional-type headache (CTTH) according to criteria established on International Headache Classification, second edition (IHCD-II), 2003, by the Headache Classification Subcommittee as part of the International Headache Society (IHS). 173 out of 462 doctors members of the Cooperative were contacted and 91 of these accepted to take part in the study. Results. In the group of 91 doctors interviewed, 51 (56%) were male, 35 (38,5%) were female and five (5,5%) refused to answer. Their age varied from 27 to 70 years old (44,8 + 09 years old). Their experience as doctors varied from three to 46 years (21,4 + 8,2 years). 67 (73.6%) stated to have been in a medical internship. The doctors interviewed were doctors of several areas. About the accuracy of the diagnostic test, concerning MO, 60 participants (66%) identified the case as migraine, only two (2,2%) identified the MO subtype and two (2,2%) suggested it was a case of mere headache. For the clinical case of MA, 25 doctors (27,5%) said it was a case of migraine and only one (1,1%) identified it as MA. About the diagnostic of CTTH, 12 doctors (13,2%) acknowledged it as tensional headache and there was not any reference to the CTTH subgroup. Among other possibilities of diagnostic, the most mentioned ones were migraine 36 (39,6%), secondary headache to systemic arterial hypertension 12 (13,2%) and headaches caused by brain expansive process 06 (6,6%). For the three clinical cases, most of the doctors researched 79 (86,8%) in the example of MO, 74 (81,3%) in the cases of MA and 71 (78%) in the example of CTTH wouldn´t prescribe complementary exams. Regarding treatment 77 (84,6%) in the case of MO, 80 (87,9%) in the case of MA and 67 (73,6%) in the case of CTTH decided not to treat it. Among those who forwarded the case to a neurologist, we have 67 (73,6%) for MO, 78 (85,7%) for MA and 59 (64,8%) for CTTH. 65 (71,4%) doctors who were interviewed said to be unaware of the IHS diagnostic criteria for primary headaches. Conclusion. Migraine was the most common initial diagnosis for any kind of headache without any identification of the subgroups. The CTTH was subdiagnosed being frequently misidentified as migraine cases despite it is the most prevailing kind of primary headache. Most of the doctors interviewed (p<0,05) does not prescribe complementary exams for headache patients and prefer to forward them to a specialist, choosing not to treat them. These results show the lack of information found in the doctors interviewed about the diagnostic criteria for the several kinds of primary headaches.
Foram entrevistados médicos pertencentes a uma Cooperativa de Serviços Médicos, na cidade de Campina Grande, com o objetivo de investigar a acurácia diagnóstica desses profissionais frente a casos clínicos de cefaléia primária, além de apreciar seus conhecimentos sobre a classificação das cefaléias e condutas quanto à solicitação de exames e indicações terapêuticas. Metodologia: Utilizou-se o método de observação direta extensiva através da aplicação de questionário. Foram apresentadas a todos os médicos entrevistados três histórias clínicas, fictícias, reproduzindo quadros de cefaléias primárias freqüentes, a saber: migrânea com aura (MCA), migrânea sem aura (MSA) e cefaléia do tipo tensional crônica (CTTC), seguindo os critérios da Classificação Internacional das Cefaléias, 2ª. Edição (IHCD-II), em 2003, elaborados pelo Subcomitê de Classificação das Cefaléias da Sociedade Internacional de Cefaléia (IHS). Foram contatados 173 médicos, de um total de 462 cooperados, dos quais 91 aceitaram participar do estudo. Resultados: Eles eram 51 homens (56%) e 35 mulheres (38,5%), cinco (5,5%) não identificaram o gênero. A idade variou entre 27 e 70 anos (44,8 + 09 anos). Eles tinham entre três e 46 anos de formados (21,4 + 8,2 anos). 67 (73,6%) afirmaram ter feito residência médica. Os médicos entrevistados atuavam nas mais diversas especialidades. Em relação ao índice de acerto diagnóstico, no exemplo de MSA, 60 participantes (66,2%) identificaram o quadro como migrânea, enquanto apenas dois (2,2%) identificaram o subtipo MSA e dois (2,2 %) sugeriram tratar-se apenas de cefaléia. No caso clínico de MCA, 25 (27,5%) disseram tratar-se de quadro de migrânea e apenas um (1,1%) respondeu ser MCA. Quanto ao diagnóstico de CTTC, 12 (13,2%) reconheceram tratar-se de cefaléia tensional, não houve acerto diagnóstico no subgrupo CTTC, e dentre outras possibilidades diagnósticas as mais citadas foram: migrânea 36 (39.6%), cefaléia secundária a hipertensão arterial sistêmica 12 (13,2%) e cefaléias ocasionadas por processo expansivo cerebral seis (6,6%). Nos três casos clínicos, a maior parte dos profissionais pesquisados 79 (86,8%) no exemplo de MSA, 74 (81,3%) nos casos de MCA e 71 (78%) no exemplo de CTTC - não solicitaria exames complementares. Quanto ao tratamento: 77 médicos (84,6%) no caso de MSA, 80 (87,9%) no caso de MCA e 67 (73,6%) no caso de CTTC, optaram por não tratar. Preferiram encaminhar ao neurologista: 67 médicos (73,6%) para MSA, 78 (85,7%) para MCA e 59 (64,8%) para CTTC. 65 (71,4%) dos entrevistados afirmaram desconhecer os critérios diagnósticos da IHS para cefaléias primárias. Conclusão: O diagnóstico inicial mais freqüente foi migrânea, comumente usado para identificar qualquer tipo de cefaléia, sem, contudo identificar seus subgrupos. A cefaléia do tipo tensional foi subdiagnosticada, freqüentemente sendo confundida com quadros de migrânea, a despeito de ser o tipo mais prevalente de cefaléia primária. A maioria (p<0,05) dos médicos não solicita exames complementares para portadores de cefaléia e prefere encaminhá-los ao especialista, optando por não tratar. Esses resultados demonstram a falta de informações por parte dos médicos entrevistados sobre os critérios diagnósticos para os diversos tipos de cefaléias primárias.

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Honekamp, Wilfried, i Thomas Giese. "Prävalenz von Kopfschmerzen und die damit verbundene Arztkonsultationsquote". Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2010. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-39536.

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Einleitung: Im Rahmen eines Projekts wird untersucht, ob sich medizinische Laien mit einem neugestalteten internetbasierten Informationssystem besser informieren können, als dieses mit Suchmaschinen und Gesundheitsportalen möglich ist. Die Evaluation eines Systems zur Informationsversorgung von Kopfschmerzpatienten ist nur dann sinnvoll, wenn tatsächlich viele Menschen im deutschsprachigen Raum unter Kopfschmerzen leiden und mit Ihren Beschwerden eher das Internet als einen Arzt konsultieren. Daher wurde in drei Studien die Prävalenz von Kopfschmerzen und die damit verbundene Arztkonsultationsquote untersucht. Methode: Dazu wurden 2000 Versicherte der BARMER Ersatzkasse, ca. 9000 Studenten der Hochschule Bremen und ca. 1000 Studenten der Universität für Gesundheitswissenschaften, Medizinische Informatik und Technik in Tirol, Österreich (UMIT) angeschrieben und gefragt, ob sie unter Kopfschmerzen leiden und wenn ja, ob sie für ihre Kopfschmerzen bereits eine ärztliche Diagnose haben. Insgesamt nahmen 521 Personen an der Untersuchung teil. Ergebnisse: Davon litten 292 Teilnehmer (56 %) unter Kopfschmerzen. Eine ärztliche Diagnose für diese hatten 52 (18 %). Alles in allem zeigt sich damit eine etwas geringere Kopfschmerzprävalenz als in den vorangegangen Studien. Die in der Literatur genannte Arztkonsultationsquote wird bestätigt. Diskussion: Die Auswertung der drei Studien zeigte, dass die Prävalenz von Kopfschmerzen weiterhin hoch und die damit verbundene Arztkonsultationsquote immer noch gering ist
Introduction: In a project, it is investigated whether a newly designed web-information system can better inform medical laymen than traditional search engines and health portals. The evaluation of a system for providing information to headache patients is only useful when in fact many people suffer from headaches in the German speaking area and if these people with their complaints rather consult the Internet than a practitioner. Therefore, in three studies the prevalence of headache and the associated physician consultation rate was examined. Method: About 9000 students of the University of Applied Sciences Bremen, 2000 insurants of the BARMER, and about 1000 students of the University of Health Sciences, Medical Informatics and technology Tyrol, Austria (UMIT) were asked if they suffer from headaches and if so whether they already have a medical diagnosis. A total of 521 persons participated in the investigation. Results: From headaches suffered 292 (56%) participants. A medical diagnosis for these had 52 (18%). All in all, it shows slightly lower headache prevalence than found in previous studies. The medical consultation rate cited in the literature is confirmed. Discussion: The evaluation of the three studies showed that the prevalence of headache remains high and the associated physician consultation rate is still low

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Bahra, Anish. "Cluster headache". Thesis, University College London (University of London), 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.397164.

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Mercante, Juliane Prieto Peres. "Comorbidade entre cefaléias primárias e transtorno de ansiedade generalizada". Universidade de São Paulo, 2008. http://www.teses.usp.br/teses/disponiveis/5/5142/tde-02042008-135616/.

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INTRODUÇÃO. A comorbidade entre cefaléias e transtornos psiquiátricos vem sendo enfatizada como um dos aspectos mais importantes no manejo dos pacientes com cefaléias primárias. Os transtornos de ansiedade, além dos de humor, são um dos diagnósticos de maior importância neste contexto. O transtorno de ansiedade generalizada (TAG) é o transtorno de ansiedade mais associado à enxaqueca. Apesar da relevância do tema, é surpreendente a escassez de estudos sobre o impacto das cefaléias primárias em pacientes com TAG. OBJETIVO. O objetivo deste estudo foi de avaliar a prevalência ao longo da vida e o impacto das cefaléias primárias em pacientes com e sem TAG. MÉTODOS. Sessenta pacientes foram incluídos no estudo: 30 pacientes com diagnóstico de TAG, de acordo com a entrevista estruturada SCID-1/P, e 30 controles saudáveis. Todos os pacientes passaram por entrevista clínica enfocando variáveis demográficas (idade, sexo, escolaridade e estado civil), antropométricas (peso, altura e IMC), relativas às cefaléias (intensidade, duração, freqüência, aura, tempo de história e consumo de analgésicos), gravidade da sintomatologia (ansiosa, depressiva, de fadiga e de sonolência diurna) e conseqüências médico-sociais (incapacidade funcional, utilização de serviços de saúde e qualidade de vida). As cefaléias primárias foram avaliadas através de entrevista estruturada e foram empregados os critérios da Classificação Internacional das Cefaléias (2a edição) para realização de seu diagnóstico. RESULTADOS. 86,6% dos pacientes com TAG receberam algum diagnóstico de cefaléia, sendo a enxaqueca o diagnóstico mais comum. Comparados aos controles, os pacientes com TAG apresentaram odds ratio maior para cefaléias primárias (RC=7,43) e também para enxaqueca (RC=13,00), enxaqueca episódica (RC=6,88) e aura (RC=10,55). Já nos controles, apenas 47% receberam algum diagnóstico de cefaléia, sendo CTT episódica infreqüente o diagnóstico mais comum. DISCUSSÃO/CONCLUSÃO. O diagnóstico de cefaléias primárias é mais comum em pacientes com TAG do que nos controles. A enxaqueca é o diagnóstico mais comum em pacientes com TAG e também mais freqüente em TAG que em controles. A cefaléia do tipo tensional (CTT) freqüente é igualmente comum em ambos os grupos. É importante realizar o diagnóstico de cefaléias primárias em pacientes com transtornos de ansiedade, em especial o TAG, pois a sua correta avaliação deve implicar em um manejo mais preciso dos pacientes com TAG e resultar em desfechos clínicos mais favoráveis.
OBJECTIVES. Anxiety disorders and headaches are comorbid conditions, but no research has been done on the prevalence and impact of primary headaches in generalized anxiety disorder (GAD) patients. The study\'s aim was to analyze lifetime prevalence and impact of primary headaches in patients with and without generalized anxiety disorder. METHODS. Sixty participants were enrolled in the study; 30 GAD patients diagnosed according to the DSM-IV were compared to 30 healthy control subjects. All patients were interviewed for psychiatric assessment using the SCID-I/P. Primary headaches were diagnosed using ICHD-II criteria for structured interview. RESULTS. Migraine was the most common diagnosis in generalized anxiety disorder patients. The prevalence of migraine was highest among GAD patients as opposed to controls (66.7% vs 13.3%; p<0.001; OR=13.00; 95% CI=3.55-47.6), episodic migraine (43.3% vs 10%; p=0.004; OR=6.88; 95% CI=1.71-27.75), chronic daily headache (20% vs 0; p=0.024) and aura (26.6% vs 3.3%; p=0.026; OR=10.55; 95% CI=1.23-90.67). Tension Type Headache (TTH) was equal for controls and the GAD group (20% vs 33.3%; p=0.243).The characteristics of migraines (frequency, intensity, duration, and consumption of analgesics), symptoms such as anxiety, depression, fatigue, and daytime sleepiness, as well as the medical-social consequences (functional incapacity, use of health services and quality of life) were worse in GAD patients than in controls. CONCLUSION. Primary headaches in general, and migraine in particular, are significantly more common in GAD patients than controls. GAD aggravates headaches. Primary headache diagnosis is important for anxiety disorder patients, particularly those with GAD, since correct assessment may lead to better patient management and clinical outcomes.

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Oster, Isabel Maria [Verfasser], i Ludwig [Akademischer Betreuer] Gortner. "Diagnostic approach to children with minor traumatic brain injury and children with headaches in Germany : The role and limitations of the electroencephalogram and imaging studies (MRI) / Isabel Maria Oster ; Betreuer: Ludwig Gortner". Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2016. http://d-nb.info/1114136379/34.

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Marklund, Susanna. "Temporomandibular disorders : incidence, course, and risk factors". Doctoral thesis, Umeå universitet, Klinisk oral fysiologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-25689.

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Temporomandibular disorders (TMD) embrace pain and dysfunction in the temporomandibular joint (TMJ) and jaw muscles. TMD is a prevalent condition in the population and constitutes a significant health problem. Knowledge of factors influencing the onset and course of TMD is important in preventive care and development of treatment strategies as well as in clinical decision making. The aim of this thesis was to gain knowledge of whether variations in dental occlusion, bruxism, spinal pain and gender predicted the development and course of TMD. The study population comprised 371 undergraduate dental students. A questionnaire was used to obtain case histories. Clinical examination included the function of the TMJ, jaw muscles, maximal jaw mobility, the morphological occlusion, and contact patterns in centric and eccentric positions. The examinations were performed at start, and after 12 and 24 months. In total, 280 subjects were examined at all three occasions. The incidence of TMJ pain and dysfunction was high among both males and females. The course composed onset, recovery and maintenance resulting in a fluctuating pattern. Females were more likely to have persistent TMJ pain and dysfunction than males. The incidence and persistence of jaw muscle signs and symptoms was high and significantly more common in females. A similar fluctuating pattern as for TMJ pain and dysfunction was found. Crossbite predicted onset and persistence of TMJ pain and dysfunction; mandibular instability in centric positions predicted persistent TMJ pain and dysfunction, as well as persistent jaw muscle signs or symptoms. Reported bruxism increased the risk for TMJ pain and dysfunction but did not significantly affect the course of jaw muscle signs and symptoms. Spinal pain at baseline predicted the onset of jaw pain, headaches, and TMD pain. Signs of TMD at baseline predicted the onset of non-pain symptoms of TMD, jaw pain, headaches, and spinal pain. In conclusion, the results in this thesis show high incidence rates for TMD, headaches, and spinal pain among dental students. Crossbite, mandibular instability, reported bruxism, as well as female gender were identified as contributing risk factors. Spinal pain and TMD mutually predicted each other, indicating common pathophysiological mechanisms and individual vulnerability. The findings support a multidisciplinary approach, and it is recommended that the status and function of the jaw system be considered in patients with spinal pain.

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Wiesinger, Birgitta. "On the relationship between spinal pain and temporomandibular disorders". Doctoral thesis, Umeå universitet, Klinisk oral fysiologi, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-31240.

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Both spinal pain and temporomandibular disorders (TMD) commonly occur in the general population. Previous studies demonstrate neurophysiologic and biomechanical couplings between the trigeminal and cervical regions. This investigation tested the null hypothesis of no relationship between spinal pain (neck, shoulder and/or low back) and TMD, by using questionnaires and clinical examinations of the jaw function. In an age- and sex-matched case-control study, the specific aim was to compare the prevalence of signs and symptoms of TMD among cases with long-term spinal pain and controls without spinal pain. The results showed that subjects with spinal pain had signs and symptoms of TMD significantly more often than did controls. The associations remained after excluding all participants with jaw pain. Furthermore, the comorbidity pattern was similar, regardless of location of spinal pain. In a cross-sectional study, the specific aim was to test whether there is a reciprocal cross-sectional dose-response-like relationship between spinal pain and TMD. Two different designs were used, one with frequency/severity of spinal pain as independent variable, and the other, with frequency/severity of TMD symptoms as independent variable. The analysis showed increasing odds for presence of TMD symptoms with increasing frequency/severity of spinal pain, and increasing odds for presence of spinal pain with increasing frequency/severity of TMD symptoms. In a case-control study within a 2-year prospective cohort, the specific aim was to test whether there is a reciprocal temporal relationship between signs and symptoms in trigeminally, and symptoms in spinally, innervated areas. Incidence of symptoms in these areas was analyzed in relation to presence of spinal pain, headaches, and signs and symptoms of TMD at baseline. The main findings were that presence of signs of TMD at baseline increased the onset of spinal pain and symptoms in the trigeminal area, and that spinal pain increased the onset of symptoms in the trigeminal area. An augmentation effect between the significant baseline variables was observed for the incidence of headaches and jaw pain. In conclusion, the investigation demonstrated a cross-sectional and temporal relationship between spinal pain and TMD; thus, the null hypothesis was rejected. The results indicate common pathophysiological mechanisms in the development of spinal pain and TMD. The comorbidity and reciprocal influence that were found call for an integrated and multidimensional approach in the management of individuals with long-term spinal pain and TMD.

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