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Artykuły w czasopismach na temat "Guieranone A"
Moreira, Rute, Federico Ferreres, Ángel Gil-Izquierdo, Nelson G. M. Gomes, Luísa Araújo, Eugénia Pinto, Paula B. Andrade i Romeu A. Videira. "Antifungal Activity of Guiera senegalensis: From the Chemical Composition to the Mitochondrial Toxic Effects and Tyrosinase Inhibition". Antibiotics 12, nr 5 (8.05.2023): 869. http://dx.doi.org/10.3390/antibiotics12050869.
Pełny tekst źródłaSilva, Olga, i Elsa T. Gomes. "Guieranone A, a Naphthyl Butenone from the Leaves ofGuiera senegalensiswith Antifungal Activity". Journal of Natural Products 66, nr 3 (marzec 2003): 447–49. http://dx.doi.org/10.1021/np0204904.
Pełny tekst źródłaMcCulloch, Malcolm W. B., i Russell A. Barrow. "A metalation strategy for the construction of functionalized naphthalenes: the first synthesis of guieranone A". Tetrahedron Letters 46, nr 44 (październik 2005): 7619–21. http://dx.doi.org/10.1016/j.tetlet.2005.08.127.
Pełny tekst źródłaKuete, Victor, Tolga Eichhorn, Benjamin Wiench, Benjamin Krusche i Thomas Efferth. "Cytotoxicity, anti-angiogenic, apoptotic effects and transcript profiling of a naturally occurring naphthyl butenone, guieranone A". Cell Division 7, nr 1 (2012): 16. http://dx.doi.org/10.1186/1747-1028-7-16.
Pełny tekst źródłaMcCulloch, Malcolm W. B., i Russell A. Barrow. "A Metalation Strategy for the Construction of Functionalized Naphthalenes: The First Synthesis of Guieranone A." ChemInform 37, nr 7 (14.02.2006). http://dx.doi.org/10.1002/chin.200607220.
Pełny tekst źródłaRozprawy doktorskie na temat "Guieranone A"
Ourhzif, El-Mahdi. "Synthèse et évaluation pharmacologique de composés originaux de la famille des méthoxynaphtalènes et lignanes arylnaphtalènes à visée antitumorale". Electronic Thesis or Diss., Université Clermont Auvergne (2021-...), 2022. http://www.theses.fr/2022UCFAC016.
Pełny tekst źródłaBreast cancer is the most common malignant tumor in women, and the first in terms of incidence (2.1 million new cases worldwide in 2018). An increasing problem is the resistance of some cancer cells to different treatments. Due to its major impact on the population, this disease represents a critical public health problem that requires additional research at the molecular level in order to define specific therapies. The plant kingdom remains an essential source for many researchers in order to find new biologically active molecules, which can lead to the discovery of active ingredients. It is in this approach that the work carried out by our research group, in the field of the extraction and synthesis of analgesic and anticancer substances from plants used in traditional pharmacopoeia, led us to consider serial pharmacomodulations on analogues of « Guieranone A », a natural molecule isolated from the leaves of the Guiera senegalensis plant which is widely used in traditional African medicine for its therapeutic properties and which has remarkable antiproliferative activities on various tumor lines and in particular on breast cancer (MCF-7 hormone-dependent line, IC50 = 3.42 ± 0.090 µM). We have therefore developed a synthetic approach using 3,4-dimethoxy benzaldehyde as a starting material and involving Stobbe and Wittig-Horner-Emmons reactions. The synthetic reactions developed on this basis, as well as the molecules prepared, have opened a synthetic route to lignans and aza-lignans, compounds of biological and / or pharmacological interest well represented in many aromatic and medicinal plants (AMP), of the genus Justicia and Vitex. By this way, Justicidin C, Cilinaphthalide B, and Methoxy-vitedoamine A were prepared via a chloroformylation reaction followed by a Suzuki-Miyaura coupling reaction