Rozprawy doktorskie: „GO-GO Models”

1

Danielsson, Christian. "Role of the hERG-channel in arrhythmia and teratogenicity studies in animal models and the human embryonic heart /". Stockholm, 2010. http://diss.kib.ki.se/2010/978-91-7409-831-0/.

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Siami, Navid. "An investigation of no-go theorems in hidden variable models of quantum mechanics". Thesis, University of British Columbia, 2016. http://hdl.handle.net/2429/57364.

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Realism defined in EPR paper as “In a complete theory there is an element corresponding to each element of reality.” Bell showed that there is a forbidden triangle (Realism, Quantum Statistics, and Locality), and we are only allowed to pick two out of three. In this thesis, we investigate other inequalities and no-go theorems that we face. We also discuss possible Hidden Variable Models that are tailored to be consistent with Quantum Mechanics and the specific no-go theorems. In the special case of the Leggett Inequality the proposed hidden variable is novel in the sense that the hidden variable is in the measurement device rather than the wave-function.
Science, Faculty of
Physics and Astronomy, Department of
Graduate

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3

Kamenetsky, Dmitry, i dkamen@rsise anu edu au. "Ising Graphical Model". The Australian National University. ANU College of Engineering and Computer Science, 2010. http://thesis.anu.edu.au./public/adt-ANU20100727.221031.

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The Ising model is an important model in statistical physics, with over 10,000 papers published on the topic. This model assumes binary variables and only local pairwise interactions between neighbouring nodes. Inference for the general Ising model is NP-hard; this includes tasks such as calculating the partition function, finding a lowest-energy (ground) state and computing marginal probabilities. Past approaches have proceeded by working with classes of tractable Ising models, such as Ising models defined on a planar graph. For such models, the partition function and ground state can be computed exactly in polynomial time by establishing a correspondence with perfect matchings in a related graph. In this thesis we continue this line of research. In particular we simplify previous inference algorithms for the planar Ising model. The key to our construction is the complementary correspondence between graph cuts of the model graph and perfect matchings of its expanded dual. We show that our exact algorithms are effective and efficient on a number of real-world machine learning problems. We also investigate heuristic methods for approximating ground states of non-planar Ising models. We show that in this setting our approximative algorithms are superior than current state-of-the-art methods.

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4

Huber, Florian, Gregor Kastner i Martin Feldkircher. "Should I stay or should I go? A latent threshold approach to large-scale mixture innovation models". Wiley, 2019. http://dx.doi.org/10.1002/jae.2680.

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We propose a straightforward algorithm to estimate large Bayesian time-varying parameter vector autoregressions with mixture innovation components for each coefficient in the system. The computational burden becomes manageable by approximating the mixture indicators driving the time-variation in the coefficients with a latent threshold process that depends on the absolute size of the shocks. Two applications illustrate the merits of our approach. First, we forecast the US term structure of interest rates and demonstrate forecast gains relative to benchmark models. Second, we apply our approach to US macroeconomic data and find significant evidence for time-varying effects of a monetary policy tightening.

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5

Parikesit, Arli Aditya. "Evolutionary Analysis of the Protein Domain Distribution in Eukaryotes". Doctoral thesis, Universitätsbibliothek Leipzig, 2012. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-100869.

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Investigations into the origin and evolution of regulatory mechanisms require quantitative estimates of the abundance and co-occurrence of functional protein domains among distantly related genomes. The metabolic and regulatory capabilities of an organism are implicit in its protein content. Currently available methods suffer for strong ascertainment biases, requiring methods for unbiased approaches to protein domain contents at genome-wide scales. The discussion will be highlighted on large scale patterns of similarities and differences of domain contains between phylum-level or even higher level taxonomic groups. This provides insights into large-scale evolutionary trends. The complement of recognizable functional protein domains and their combinations convey essentially the same information and at the same time are much more readily accessible, although protein domain models trained for one phylogenetic group frequently fail on distantly related sequences. Transcription factors (TF) typically cooperate to activate or repress the expression of genes. They play a critical role in developmental processes. While Chromatin Regulation (CR) facilitates DNA organization and prevent DNA aggregation and tangling which is important for replication, segregation, and gene expression. To compare the set of TFs and CRs between species, the genome annotation of equal quality was employed. However, the existing annotation suffers from bias in model organism. The similar count of transcripts are expected to be similar in mammals, but model organism such as human has more annotated transcripts than non model such as gorilla. Moreover, closely related species (e.g, dolphin and human) show a dramatically different distribution of TFs and CRs. Within vertebrates, this is unreasonable and contradicts phylogenetic knowledge. To overcome this problem, performing gene prediction followed by the detection of functional domains via HMM-based annotation of SCOP domains were proposed. This methods was demonstrated to lead toward consistent estimates for quantitative comparison. To emphasize the applicability, the protein domain distribution of putative TFs and CRs by quantitative and boolean means were analyzed. In particular, systematic studies of protein domain occurrences and co-occurrences to study avoidance or preferential co-occurrence of certain protein domains within TFs and CRs were utilized. Pooling related domain models based on their GO-annotation in combination with de novo gene prediction methods provides estimates that seem to be less affected by phylogenetic biases. it was shown for 18 diverse representatives from all eukaryotic kingdoms that a pooled analysis of the tendencies for co-occurrence or avoidance of protein domains is indeed feasible. This type of analysis can reveal general large-scale patterns in the domain co-occurrence and helps to identify lineage-specific variations in the evolution of protein domains. Somewhat surprisingly, strong ubiquitous patterns governing the evolutionary behavior of specific functional classes were not found. Instead, there are strong variations between the major groups of Eukaryotes, pointing at systematic differences in their evolutionary constraints. Species-specific training is required, however, to account for the genomic peculiarities in many lineages. In contrast to earlier studies wide-spread statistically significant avoidance of protein domains associated with distinct functional high-level gene-ontology terms were found.

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Wagnberg, Michael, i Peter Danielsson. "Internal Dashboard". Thesis, Linnéuniversitetet, Institutionen för datavetenskap och medieteknik (DM), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-77676.

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This project is about creating a Dashboard with suitable data models containing support ticket statistics for the company Sigma IT Consulting. The work flow used by Sigma today is to manually log in to the system to see the support ticket statistics, which can be a tedious and time consuming process. Furthermore, Sigma do not have any monitoring system for checking the health of their web application services. They have a need for an internal Dashboard containing this information with regularly updates. Our solution is to design suitable data models and implement them within a Dashboard application.

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Castro, Millades de Carvalho. "Risco na variação de preços agropecuários: um estudo para os mercados de soja, milho e boi gordo no município de Rio Verde-GO, 2004 a 2014". Universidade Federal de Goiás, 2016. http://repositorio.bc.ufg.br/tede/handle/tede/6057.

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Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG
Volatility in the prices of commodities and the financial return of agricultural activities affect the choice of what to produce. The present work investigates volatilities in prices of cattle, soybeans, and corn in Rio Verde (GO, Brazil), the choice of this region should be the importance of the city in the state and national agricultural production. For this study, we analyze weekly prices of corn, soybeans and cattle in Rio Verde spot market from 2004 to 2014, using Time Series Analysis and Value at Risk. The examination of the series pointed to the presence of a conditional variance. Therefore the ARCH / GARCH models were applied. The model selected to soybean was the IGARCH (2.1) and to corn and cattle the EGARCH (1.1). Due to disproportion between the traded prices and volumes it was not possible to perform the VAR series comparison. Therefore we used the ratio between the VAR and revenue of each product to compare between markets. Results showed a higher ratio for the cattle series indicating that volatility affects cattle producers’ income more than that of soybean or corn producers in Rio Verde (GO), which resulted in the reduction of this activity in the region.
A volatilidade nos preços das commodities e o retorno financeiro das atividades agropecuárias afetam a escolha do que produzir. O presente trabalho visa investigar as volatilidades nos preços do boi e das culturas de soja e milho para o município de Rio Verde (GO, Brasil), no período de 2004 a 2014, a escolha dessa região deve-se a importância do município na produção agropecuária estadual e nacional. Para tanto, utilizou-se de dados semanais de preços de milho, soja e boi no mercado físico de Rio Verde no período de 2004 a 2014. A metodologia usada foi a usual de análise de séries temporais e cálculo do Value at Risk (VaR). O exame das séries apontou a presença de variância condicional, sendo então aplicados os modelos ARCH/GARCH.O modelo selecionado para soja foi o IGARCH (2,1) e para milho e boi o EGARCH (1,1). Posteriormente, o cômputo do VaR para cada uma das séries não é suficiente para comparação, devido a desproporção entre os preços e os volumes negociados. Logo, para que fosse possível a comparação entre os mercados, utilizou-se da razão entre VaR e a receita de cada produto. Os resultados apontaram que em média, a razão foi maior para a série bovina. Portanto, a volatilidade compromete a receita dos produtores bovinos mais do que os agricultores de milho e soja no município de Rio Verde (GO), o que implicou na redução dessa atividade na região.

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Latvys, Andrius. "Pensijų draudimo modeliai (principai, socialinės pasekmės, ilgalaikės perspektyvos)". Master's thesis, Lithuanian Academic Libraries Network (LABT), 2012. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2012~D_20120703_161004-25589.

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Dauguma išsivysčiusių pasaulio šalių susiduria su senatvės pensijų sistemos mokumo problemomis, todėl senatvės pensijų modelių analizei ir jų tobulinimui pastaraisiais dešimtmečiais skiriama vis daugiau dėmesio. Tyrimo objektu pasirinkti senatvės pensijų draudimo modeliai. Tyrimo problema yra ta, kad nėra vieno ir tobulo senatvės pensijų sistemos modelio, kurį būtų galima efektyviai pritaikyti esant konkrečioms ekonominėms, socialinėms ir demografinėms aplinkybėms. Tyrimo tikslas yra išanalizuoti įvairius senatvės pensijų draudimo modelius, identifikuoti pagrindinius jų parametrus, išskirti pagrindinius finansavimo ir išmokų mokėjimo būdus bei įvertinti priežastis, lemiančias modelių pasirinkimą bei jų tęstinumą užtikrinančius kriterijus, atlikti Lietuvos senatvės pensijų sistemos vertinimą. Darbe atlikta mokslinė užsienio ir lietuvių literatūros bei statistinių duomenų analizė, siekiant atskleisti senatvės pensijų modelius, kitimą, problemas ir svarbiausius teorinius aspektus, taip pat atliktas tyrimas siekiant įvertinti Lietuvos senatvės pensijų sistemą. Darbas susideda iš trijų skyrių. Pirmame skyriuje „Senatvės pensijų draudimo modeliai“ apibrėžiama senatvės pensinio draudimo ir tradicinių pensinių draudimo modelių samprata, susijusios sąvokos, administravimo būdai, analizuojami einamųjų mokėjimų ir kaupimo modeliai, pensijų pakopos. Pateikiami mokslininkų tyrimai ir nuomonės apie skirtingus modelius. Antrame skyriuje „Lietuvos senatvės pensijų draudimo modelis“... [toliau žr. visą tekstą]
Most developed countries faces a pension system solvency problems, that‘s why in recent decades old-age pension models analysis and development has received increasing attention. Object of study is chosen old-age pension models. The research problem is that there is no one perfect model, which can be effectively applied to specific economic, social or demographic circumstances. The aim of study is to analyze variety old-age pension models, identify key parameters, distinguish the main financing and payment methods and assess the reasons which influence the choice of models, evaluate Lithuania old-age pension system. Analysis of scientific foreign and Lithuania literature and statistical data are done in study, on purpose to reveal the problems, dynamics and the most important theoretical aspects, also a research is done to evaluate the Lithuanian old-age pension system. The study consists of three chapters. In the first part “The old-age pension models” are defined the concept of old age pension, related terms, traditional old-age models concepts, pension system administration methods are related, pay-as-you-go and fully funded models and pension pillars are analyzed. Scientific research and opinion are presented about different models. In the second part “Lithuania old-age pension model” Lithuania old age pension model is analyzed: current state, funding, legislative basis, performed a statistical data analysis. In the third part respondent’s systematized survey are... [to full text]

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Dixon, Diane. "Conceptual and measurement models of disability". Thesis, University of Aberdeen, 2006. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU206100.

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Numerous theoretical frameworks have been applied to further our understanding of the correlates, causes and consequences of disability, and each is accompanied by a particular conceptualisation of disability. In this thesis, disability was conceptualised as behaviour. The concept of disability as behaviour is accompanied by psychological theories of behaviour and behaviour change within which behaviour is viewed as a product of motivational factors. A repertory grid study indicated that people with mobility disability use motivational concepts to distinguish between physical activities typically used to index their disability. These data lent support to the suitability of the disability as behaviour concept in this population. Consequently, psychological theory, in the form of the theory of planned behaviour (TPB) and social cognitive theory (SCT), was used to account for walking disability in an orthopaedic sample. The empirical application of psychological theories requires the operationalisation of the constructs within those theories. An investigation of the content validity of existing measures of the perceived control constructs from the TPB and SCT indicated current measurement items do not show discriminant content validity. These data were used to select perceived control items into the study of disability in an orthopaedic sample. The content validity of the perceived control items was investigated using confirmatory factor analyses applied to the responses of the orthopaedic sample. Structural equation modelling indicated that both the TPB and SCT could account for walking disability in the orthopaedic sample. Finally, the ability of the TPB and SCT to mediate between the central constructs of the main medical model of disability, namely the International Classification of Functioning Disability and Health (ICF), was assessed using structural modelling. This integrated model accounted for a greater proportion of the variance in walking disability than did the ICF alone, suggesting psychological theory can be used to improve the ICF model.

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Sims, Michelle. "Applications of mixed models in ecology". Thesis, University of Aberdeen, 2005. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU206519.

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Statistics is a science that deals with variability in data. The presence of variation in natural processes means that statistics has a central role within a discipline such as ecology. Thus, any technique that determines the sources of variability will play a prominent part in the statistical modelling of ecological data. My thesis addresses one popular approach, a mixed model analysis. The practical use of mixed models in ecological research had at one time been limited to occasions in which experiments involved balanced data. Given the infrequent occurrence of such events, there were few practical applications of mixed models in the ecological literature. The development of methods for fitting mixed models to unbalanced data and the wider availability of the software to fit them were the seeds for the now growing trend in mixed model analysis among ecologists. During my PhD I focused on the development and novel application of mixed models in ecology. The work presented in this thesis was motivated by four examples, each involving unbalanced data with complex correlation structures. The intention of each example, motivated by specific questions of interest, was to explore the extent to which mixed model methodology could be practically applied in ecology. Features of a mixed model analysis were manipulated in each example to address a number of general issues in ecological statistics: how to develop efficient sampling designs; the effect of using estimated variances in power calculations; ways to handle correlated explanatory variables in a regression analysis and how to correctly model reproductive success. An additional issue concerned the estimation of a change point location in a simple change point model.

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Bierman, Stijn Martinus. "Spatio-temporal models in animal population dynamics". Thesis, University of Aberdeen, 2004. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU195633.

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Population dynamics is the study of how and why populations of animals change in distribution and abundance. Thus, the aims of the science of population dynamics are twofold: to document the empirical patterns of population distribution and change, and to determine the mechanisms underlying those observed patterns. Population dynamics data typically have rich and complex spatio-temporal patterns. Modern and flexible statistical methods are needed to describe these patterns, and for the sound estimation of parameters in realistic mathematical models of spatio-temporal population dynamics. Of particular importance has been the development over the past decade of modern computational statistical methods, such as Markov chain Monte Carlo (McMC), that enable rigorous parameter estimation for more realistic models. The work as reported in this thesis has evolved around three case studies, each involving a long-term data set of estimated abundance's of a species at different locations over time, and a specific set of questions of interest: 1) Linking the spatio-temporal variation in recruitment of the Atlantic puffin (Fractercula arctica) to the spatio-temporal variation in densities of nesting herring gulls (Larus argentatus ) and lesser black-backed gulls (Larus fuscus) within the Isle of May natural nature reserve. 2) The use of flexible statistical tools to investigate coincident changes in the spatial and temporal dynamics of cyclic populations of field voles (Microtus agrestis). 3) Investigating the metapopulation dynamics of water voles (Arvicola terrestris) in the Scottish uplands using stochastic patch occupancy models. In each case study, the central aim was to formulate mathematical models that describe the spatio-temporal dynamics of the animal populations, and to develop and investigate the uses of flexible statistical methods that can be used to inform these models using the data.

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Martin, Derek D. "Dynamic models of a small ac induction motor". Thesis, University of Aberdeen, 1995. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU068919.

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The Power Electronics Group at Aberdeen University is working towards the provision of a complete time domain model of an electrical drive for marine applications. The model has been developed using the SABER electrical simulation software package and includes a cycloconvertor which supplies an ac induction motor which in turn drives the shaft/propeller assembly. Effects such as vibration, noise and shaft oscillations due to the cycloconvertor will be studied. This thesis reports on the development and investigation of a mathematical model of the ac induction motor which can be incorporated into the existing system model to predict vibration levels at any point on the structure of the motor. The development of the mathematical model was achieved by combining a finite element (FE) representation of the motor structure with the modal parameters of the motor extracted using modal analysis techniques. The main experimental programme on the selected motor was based on a series of parallel tests on two "identical" machines. These machines were broken apart and subjected to a modal analysis at various stages. The vibration properties of a laminated structure, similar to the core of an ac motor, were also investigated. The experimental data was then used to direct the creation of the FE models. The models were created and analysed using SDRC I-DEAS integrated software. The modal analysis results were introduced into test software, where they were "curve-fitted" to extract the modal mass, modal stiffness and modal damping parameters. The FE model, created in the finite element modelling package, was then correlated with the test model and modifications implemented until the FE and test models compared well.

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Wimpenny, Peter. "An examination of nursing models from the practitioner's perspective". Thesis, University of Aberdeen, 1999. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU123926.

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This thesis reports a study that aimed to create a better understanding of nursing models. It set out to explore nursing models from the qualified nurse's perspective. Such perspective is of interest to the debate about nursing models which has often been conducted at the rhetorical rather than evidence based level. The methodological approach is that of grounded theory (Glaser and Strauss, 1967) with a three stage interview process as the data collection method. The sample comprised qualified nurses in Scotland who were undertaking educational programmes which included input on nursing models. The central themes from the interview stages were: first interview: operationalising the model; second interview: contextualising the model; and the third interview: nursing models and the reality of practice. These central themes were the foundation for the development of a three model typology distinguishing between: the theoretical model which is the conceptual model of the theorist, is abstract, general and developed through inductive and deductive approaches and presented as a potential picture of nursing; the mental model which is the personal pattern or schema of the individual nurse and represents the way nursing is described by the individual; and the Surrogate model which is a functional representation used by nurses to collect data, communicate and through which the organisation can standardise and audit practice. It is concluded that nursing models should not be seen as pertaining to a single entity but be described in the typologies described above. In this way some of the confusion about the way nursing models have been introduced and taught can be addressed. This is especially viewed in the context of models as forms of truth, external objects, adaptable, tools for use or tools for thought, as having individual or collective value and requiring evaluation from the individual's perspective.

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Dines, Kevin C. "Essential fatty acid dysmetabolism and models of diabetic peripheral neuropathy". Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU541429.

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Untreated streptozotocin-induced diabetes results in highly significant and reproducible alterations to peripheral nerve function. Thus, motor and sensor nerve conduction velocities (NCV) were decreased by approximately 21% and 14%, respectively whilst parameters of resistance to hypoxic conduction failure (RHCF) were increased by approximately 50%. NCV deficits were established after one month of untreated diabetes whilst increased RHCF continued to develop over at least two months of untreated diabetes. Dietary treatment of diabetic rats with evening primrose oil (EPO), thus overcoming the inhibition of -6 desaturase was able to prevent decreases in motor and sensor NCV whilst partially preventing the development of increased RHCF. Sciatic endoneurial capillary density was also increased. The effects of EPO were seen to be dependent on cyclo-oxygenase mediated metabolism and this, combined with the lack of effects with sunflower oil suggested gamma-linolenic acid (GLA) to be the active component in EPO. Thus, reversal and preventive treatment of diabetic rats with purified GLA, as well as iloprost (a prostacyclin (PGI2) analogue), had very similar effects to EPO. Therefore, it is likely that increased vasodilator PGI2 production underlies the mechanism of action. However, these highly beneficial effects of GLA (-6 essential fatty acid (EFA)) treatment were in contrast to the poor effects of the -3 EFAs found in fish oil. Furthermore, these -3 EFAs attenuated the actions of GLA. Both observations are linked to a possible attenuation of PGI2 synthesis and increased vasoconstrictor thromboxane (Tx) production. Several different GLA containing oils were found to be significantly less effective than EPO in the reversal of diabetic nerve conduction abnormalities.

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Pol, Marjon van der. "Intertemporal preferences for health : a comparison of the discounted utility model and hyperbolic models and of intertemporal preferences across health outcome". Thesis, University of Aberdeen, 2000. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU602020.

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It is standard practice to assume the discounted utility (DU) model on the part of the economic agents. This thesis tests the key axiom of the DU model (stationarity) in the health domain. Intertemporal preferences for health are of interest because of the debate over the appropriate treatment of future health effects in economic evaluation and of the relationship between intertemporal preferences and health-affecting behaviour. Social intertemporal preferences for fatal changes in health and private and social intertemporal preferences for non-fatal changes were elicited from members of the general public. Private intertemporal preferences for non-fatal changes were elicited from university students. Stationarity was violated in all three studies indicating that the DU model does not accurately describe individuals' intertemporal preferences. Psychologists dissatisfied with the DU model have developed hyperbolic models which replace the stationarity axiom by a generalised stationarity axiom. This thesis compared the descriptive properties of the DU model and hyperbolic discounting models in the health domain. The results showed that the hyperbolic discounting models fitted the data better than the DU model. This indicates that hyperbolic models should be preferred in the analyses of health affecting behaviour. Whether they should also be used in economic evaluations is likely to depend on other criteria as well as descriptive superiority. To inform the debate about the appropriate discount rate for health effects in economic evaluations this thesis investigated whether intertemporal preferences differ across outcomes within the health domain. The results showed that private and social intertemporal preferences for non-fatal changes in health are very similar. More differences were found between intertemporal preferences for fatal changes and non-fatal changes. This indicates that the debate over the relationship between individuals' preferences and the social discount rate is less important and that the debate should perhaps focus more on whether the rate should depend on the type of health outcome of the intervention.

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MacFarlane, Robert Hywel. "Integrating behavioural models with GIS for land-use policy impact modelling". Thesis, University of Aberdeen, 1994. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU067330.

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In this project, a range of characteristics describing farmers as decision-makers and details of their land holdings are integrated within a Geographic Information System (GIS) and used to predict overall farm response to defined policy scenarios, for a study area in the upland fringe of Grampian Region. Agriculture has undergone considerable adjustments over the past 40 years, characterised by the processes of intensification and specialisation of farming systems. These changes have been essentially policy-driven, although the precise interaction of policy, technological and macro-economic forces are not entirely understood. Further to this, rural areas are subject to an increasing range of consumption demands which has stimulated a new range of land-use policy schemes, and constraints, on farmers and landowners. From a position of assured government support which was enjoyed by the majority of farmers until the mid-1980s, the policy situation has developed into one of uncertainty and some confusion over the requirements and responsibilities placed on individual farmers. This research links spatial, behavioural and economic elements which combine to condition farm-level response to policy change. The complexity of individuals' decision environments, coupled with the diversity of individuals' values, objectives and resources is immense. The focus is on individual farms, and the implications of change at the individual level in developing a model of farm-level response to policy and market shifts.

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Kettles, Alyson McGregor. "Nurses' Attitudes Towards and Understanding of Nursing Theories, Models and Care Planning". Thesis, University of Aberdeen, 2005. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU200837.

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Aim: The research study sought to examine qualified registered nurses' attitudes towards and understanding of nursing theories, models and care planning in Scotland. Problems have been identified with the attitudes towards and understanding of nursing theories and models as well as the implementation of care planning. This is perceived as affecting the way care is carried out. Method: Qualified registered nurses' attitudes towards, understanding and knowledge of nursing theories, models and care planning in two regions of Scotland were explored. Data were collected through a questionnaire. Findings: The data suggest that there are five factor analysis themes (Enabling Theory; Caring Practice; Negative Doing; the Encompassing Nature of Nursing and Apprenticeship) concerning with nursing theories, models and care planning. These had some similarities and some differences with Benner and Wrubel's (1987) and Glen's (1998) ideas about these areas of nursing. There was a significant level of dissatisfaction with the education around care planning with more than half the respondents indicating that they had received no such training. The qualitative findings provided a more detailed picture of the quantitative results and showed that there are five groups of nurses where caring practice is involved. There was also uncertainty and confusion about whether or not nursing is an art or a science and a lack of knowledge about the issues surrounding models, theories and care planning. There is a negative attitude to care planning that specifically relates to the doing of care planning. Conclusions: There is a need to encourage the development of education about nursing theories, models and care planning for all nurses in all clinical areas because, despite the lack of credible evidence for them, there is an expectation by senior nurses that they should be used in practice.

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Hagala, Jennifer A. "HOW FAR WILL YOU GO WHEN THERE IS AN EMBARGO?A STOCHASTIC ACTOR-ORIENTED MODEL OF THE EFFECTS OF ARMS EMBARGOS ON ILLICIT WEAPONS TRADE". CSUSB ScholarWorks, 2017. https://scholarworks.lib.csusb.edu/etd/538.

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The international community routinely implements embargoes in an effort to restrict the flow of small arms and light weapons into politically unstable regions. The effectiveness of sanctions fall into question when reports indicate that weapons continue to pour into embargoed territories. Using stochastic actor-based modeling, the current study investigates how shipment patterns change over time, and how trade patterns evolve in the presence of endogenous influences, such as embargoes, while controlling for corruption levels and national wealth (e.g., gross domestic product). The analysis here indicated that embargoes did have an effect in diverting illicit weapons trade through indirect ties. This was seen highest during the embargo implementation period and post embargo implementation period. The results stand to improve our understanding of this complex illegal global market and the role national control of corruption and gross domestic product play in the enforceability of these sanctions. In the final analysis what was discovered was that embargoes do effect change in the illegal arms trade network. This effect is seen in the form of indirect ties to end user countries. This suggests that improvements to policies and regulation on transshipment points need to be highly scrutinized.

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19

Dimelow, David J. "Non-linear dynamics of an offshore mooring tower". Thesis, University of Aberdeen, 1997. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU092912.

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Offshore mooring towers are one of a number of single-point mooring (SPM) systems which provide a berthing point for tankers, enabling the transfer of crude oil to or from the moored vessel. The periodic slackening of the mooring hawser between the vessel and the tower gives rise to a discontinuously non-linear restoring function. Hence, the wave-induced motions of the tower can be highly complex, with the possibility of large amplitude, and potentially hazardous motions. A large amount of work has been carried out in studying single-point mooring systems. However, much of this work has focused on mooring forces and tanker motions. Few studies have looked in-depth at the motions of the mooring structure itself. In this thesis, mooring tower motions have been studied in detail using three techniques: numerical analysis, approximate analytical methods, and experimental modelling. Each of these approaches to the problem has demonstrated that large amplitude and hence potentially hazardous motions can occur. Numerical predictions of motion showed very good comparison with measured responses, particularly for synchronous motions. However, for more complex motions, such as subharmonic resonances, the agreement between measured and predicted results was seen to deteriorate. Approximate analytical methods did not perform so well. Useful results were obtained for the simplified single-degree-of-freedom symmetric model only, highlighting the need for a more sophisticated method. This research has been successful in providing insight into the complex non-linear motions of an offshore mooring tower. The fundamental mechanisms and features of the system have been presented. The methodology used in this study has been applied to the specific case of an offshore mooring tower. However, the general approach to investigating the non-linear motions of the structure is widely applicable in the field of offshore engineering.

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20

Vittadello, Sean T. "Mathematical models for cell migration and proliferation informed by visualisation of the cell cycle". Thesis, Queensland University of Technology, 2020. https://eprints.qut.edu.au/204074/1/Sean_Vittadello_Thesis.pdf.

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Cell migration and proliferation are essential for normal physiological processes, however their misregulation contributes to pathologies including cancer. In this thesis we develop and analyse new mathematical models of cell migration and proliferation, based on new experimental studies that provide visualisation of cell cycle progression, to improve understanding of the migration and proliferation of cells. In particular, we investigate cell migration as a function of cell cycle dynamics, normally-hidden cell synchronisation in cellular assays, whether cell migration and proliferation are mutually exclusive processes, and cellular mechanisms that contribute to heterogeneous cell proliferation.

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21

McLaren, John. "Human renal proximal tubular cells, in suspension and primary culture, as in vitro models of drug-induced nephrotoxicity". Thesis, University of Aberdeen, 1992. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU545620.

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The kidney is the target for a wide variety of chemical agents, including heavy metals, haloalkenes, analgesics and antibiotics. The functional and metabolic characteristics of the proximal tubule (PT) predispose it as the primary site for xenobiotic damage. The aim of this study was to isolate and characterise human and rat PT cells in suspension and primary culture for use as defined models to investigate drug-induced PT cell damage in vitro . A second aim was to compare the response of human and rat systems to known nephrotoxins. Human and rat PT cells (90&'37 viable) were isolated from kidney cortex by collagenase digestion followed by isopycnic Percoll density centrifugation. This resulted in the formation of two distinct bands of cell at densities 1.040g/ml (A) and 1.060g/ml (B) for both preparations. Characterisation of human cells in terms of morphology, marker enzymes, retention of active transport systems and responsiveness to parathyroid hormone indicated that &'62 95&'37 of the cells in band B were proximal tubular. Each transport system demonstrated Michaelis-Menten kinetics; kinetic parameters suggested that a higher proportion of PT cells from the S1-S2 segment of the nephron were present in human isolates. Human isolated cells also contained levels of glutathione and cytochrome P450, in particular ethoxyresorufin-O-deethylase activity, a marker for the P4501A family, similar to the intact kidney. Both human and rat cells were successfully cultured in serum-supplemented medium (10&'37 v/v) with human cells reaching confluence by 3-4 days and rat by 5-6. Maximal attachment was seen when cells from both preparations were inoculated onto collagen coated plates with an additional layer of fibronectin. Only human cells were able to reach confluence on porous membranes and demonstated an enhanced morphology when compared to normal cultured cells. Cultured cells from both preparations retained an epithelial morphology and showed minimal secondary cell contamination as shown by light microscopy and in the case of human cultures additionally through immunohistochemical staining. Immunohistochemical staining also demonstrated that human cells in culture were depositing components of the extracellular matrix. The maintenance of PT cell function, throughout the time in culture, was shown following maintenance of active transport systems, in particular the glucose carrier system and on porous membranes the organic anion system. Only rat cells maintained the organic cation system in primary culture. In addition human cells maintained the preferential response to parathyroid hormone. Except for the transport of organic cations, the other carrier systems and responsiveness to hormones were evident at both sub-confluent and confluent stages of cell culture.

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22

Fernando, Susanthi R. "Development of in vitro smooth muscle preparations as suitable models for elucidating the mechanism of action of cannabinoids". Thesis, University of Aberdeen, 1998. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU112393.

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The suitability of the electrically stimulated guinea-pig MP-LM preparation, mouse isolated vas deferens and urinary bladder for the study of cannabinoid receptor ligands was investigated. Cannabinoid receptor agonists produced concentration-related inhibition of the contractile responses in all three tissue preparations, demonstrating high potency, chemical- and stereo-selectivity. The rank order of the inhibitory potency of the cannabinoid agonists in all three tissue preparations correlated with their binding affinity for specific cannabinoid CB1 binding sites in rat brain tissue. These results suggested a receptor-mediated mechanism of action for cannabinoid receptor agonists via prejunctional functional cannabinoid CB1 receptors in these three models, in the absence of an antagonist. The endogenous cannabinoid receptor ligand anandamide, also produced concentration-related inhibitory effects in all three tissue preparations. However, anandamide was found to be metabolically less stable in the guinea-pig MP-LM preparation. SR141716A, a potent, CB1 selective cannabinoid receptor antagonist was found to attenuate the inhibitory effects of cannabinoid receptor agonists investigated in all three tissue preparations. This provided further evidence for a receptor-mediated mechanism of action for cannabinoid receptor ligands in these three tissue preparations. However, further studies with SR141716A suggests that, it may be acting as an inverse agonist rather than a pure antagonist in these three preparations. Finally, this study was further extended to characterise some novel cannabinoid receptor ligands in the guinea-pig ML-LM preparation and mouse isolated vas deferens.

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23

Bellido, Jose M. "Use of geographic information systems, spatial and environment-based models to study ecology and fishery of the veined squid (Loligo forbesi Steenstrup 1856) in Scottish waters". Thesis, University of Aberdeen, 2002. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU153971.

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This PhD studies the ecology and fishery of the veined squid Loligo forbesi in Scottish waters by making use of different spatial and statistics tools, such as Geographic Information System (GIS), Generalised Additive Models (GAMs) and Geostatistics. The PhD thesis is divided in 6 chapters, arranged in a sequential order driven by the hypothesis and question which have arisen throughout the study. Chapter 1 aims to provide a general introduction of the objectives, state of the art and techniques utilised along all this work. Chapter 2 reports the use of Geographical Information Systems (GISs) to study squid resources in the North East Atlantic. Long-term monthly average Landings Per Unit of Effort (LPUE) series are mapped against SST, SBT, SSS, SBS and Depth to reveal plausible spatio-temporal relationships between oceanographic conditions and squid abundance. Hypotheses about the squid distribution and abundance in relation to environment, habitat selection and spatial migration are suggested. Chapter 3 reports a GAM application to describing intra-annual and inter-annual variation in squid abundance in Scottish waters is also reported. Geostatistical tools were applied in chapter 4 to model spatial patterns in squid abundance in Scottish waters to explore spatial heterogeneity and distribution. Spherical and gaussian model variograms and neighbourhood analysis were made. Results provide enough evidence to indicate that there are differences between the east and the west coast of Scotland. Chapter 5 reports a two-stage model to study distribution and abundance by a Binomial and Gamma sequential approach. GAMs and Regression trees on two stages were utilised using all the available environmental variables. These non-parametric modelling was used to forecast probability of presence and abundance of 1994 by a environmental data set. Finally, chapter 6 comprises the conclusions of the work, particularly from a point of view of the ecology of the squid.

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24

Caldas, Ana Luiza Rios. "Método de diagnóstico para gestão participativa de recursos hídricos: estudo de caso e modelagem conceitual com enfoque DPSIR". Universidade Federal de Goiás, 2012. http://repositorio.bc.ufg.br/tede/handle/tede/5413.

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Submitted by Marlene Santos (marlene.bc.ufg@gmail.com) on 2016-03-24T17:15:12Z No. of bitstreams: 2 Tese - Ana Luiza Rios Caldas - 2012.pdf: 4813040 bytes, checksum: 28e7e8b9e97cb686997407a71d9c2876 (MD5) license_rdf: 19874 bytes, checksum: 38cb62ef53e6f513db2fb7e337df6485 (MD5)
Rejected by Luciana Ferreira (lucgeral@gmail.com), reason: - A inicial das palavras-chaves são em maiúsculo, portanto está errado: modelos conceituais; gestão de recursos hídricos. o certo é Modelos ... ; Gestão de ... - A citação está com problemas: use a forma que o nome aparece no campo identificação - Nome em citações bibliográficas- do currículo lattes; use f. e não p. CALDAS, A. L. R. Método de diagnóstico para gestão participativa de recursos hídricos: estudo de caso e modelagem conceitual com enfoque DPSIR. 2012. 179 f. Tese (Doutorado em Ciências Ambientais) - Universidade Federal de Goiás, Goiânia, 2012. - Colocar currículo lattes para os co-orientadores. on 2016-04-04T10:49:09Z (GMT)
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Conselho Nacional de Pesquisa e Desenvolvimento Científico e Tecnológico - CNPq
Several studies emphasize the greater effectiveness of participatory environmental management of water resources. This requires that social actors have the necessary conditions to participate in the debates, evaluate the general demands and make informed and negotiated decisions. Concept maps are adequate tools to formalize relevant knowledge, scientific and popular, facilitate the creation of a common understanding, strengthening negotiations in the processes of decision making and have been used in various ways in the management of water resources. The conceptual framework DPSIR (driving forces, pressures, state, impacts, responses) was used to guide the collection of structured information from the conceptual map, evidencing relations between the state of the environment and the pressures to which it is submitted. The overall objective is to contribute to the participative management of river basins, through the modeling of conceptual maps oriented by the DPSIR conceptual framework, starting from an qualitative environmental diagnostic, and for that it is based on a Case Study in the sub-basin of the Rio das Almas, in Pirenópolis, GO. The qualitative socio-environmental diagnosis followed a Case Study methodology from the Social Sciences. Sought to answer the question: "What are the main uses of the basin and their impacts on the conservation status of the Rio das Almas and how this comes to compromise the multiple use of water"? Three techniques were evaluated as adaptable to environmental research: investigation of environmental change over time, starting from semi-structured interviews; assessment of the current state of conservation through Rapid Assessment Protocols, as part of the technique of systematic observation; quantitative analysis of water quality data. The analysis of the results under the DPSIR focus subsidized thematic maps at the end of each section, which compositionally formed the total conceptual map. The conservation of the Rio das Almas sub-basin is good, but not homogeneous, and has been changing over the decades, as suggests all the evidence. The main impacts in the basin are mischaracterization of margins, siltation and reduction of wells and recreation sites, with lower use value by local population. With regard to water, it has been detected high concentrations of thermo tolerant coliforms, low oxygen concentration and the unviability of fishing. It was concluded that the techniques chosen complemented themselves positively. The complex diagnostic map presented here gathers within itself all the results of the Case Study. The use of concept maps in the process of data reduction allows visual identification of themes and patterns, as observed in the cultural patterns for water use observed in Pirenópolis. It was found that the DPSIR increases the effectiveness in using the concept maps, making them more robust and relevant since: it guides and supports the selection of elements to be included in the conceptual map; directs the map to a wide and complex chain of causality; shows the visualization of where and how the human dimension integrates and interferes on the state of the ecosystem. All in all, it makes the construction of conceptual maps more objective, targeting the direct application in the exercise of participatory management.
Vários estudos vêm enfatizando a maior efetividade da gestão ambiental participativa de recursos hídricos. Para isso é necessário que atores sociais tenham condições de participar dos debates, avaliar as demandas gerais e tomar decisões conscientes e negociadas. Mapas conceituais são ferramentas adequadas para formalizar conhecimentos relevantes, tanto científicos como populares, facilitam a criação de um entendimento comum, fortalecendo as negociações nos processos de tomada de decisão e vem sendo utilizados de várias formas na gestão de recursos hídricos. A estrutura conceitual DPSIR (do inglês driving forces, pressures, state, impacts, responses) foi utilizada para orientar a coleta estruturada de informações do mapa conceitual, evidenciando relações entre o estado do ambiente e as pressões a que está submetido. O objetivo geral é contribuir na gestão participativa de bacias hidrográficas, através da modelagem de mapas conceituais orientados pela estrutura conceitual DPSIR, a partir de um diagnóstico ambiental qualitativo, e que para isso fundamenta-se no delineamento Estudo de Caso, na sub-bacia do Rio das Almas, em Pirenópolis, GO. O diagnóstico socioambiental qualitativo seguiu a metodologia Estudo de Caso, das Ciências Sociais. Buscou responder à pergunta: “Quais os principais usos da bacia e seus impactos no estado de conservação do Rio das Almas e como isto vem comprometendo o uso múltiplo da água”? Três técnicas foram avaliadas como adaptáveis à pesquisa ambiental: investigação das modificações ambientais ao longo do tempo, a partir de entrevistas semi-estruturadas; avaliação do estado atual de conservação através dos Protocolos de Avaliação Rápida, como parte da técnica de observação sistemática; análise de dados quantitativos para a qualidade da água. A análise dos resultados sob o enfoque DPSIR subsidiou os mapas temáticos ao final de cada seção, que composicionalmente formaram o mapa conceitual total. A conservação da sub-bacia do Rio das Almas é boa, mas não homogênea, e vem se modificando ao longo das décadas segundo todas as evidências. Os principais impactos na bacia são descaracterização das margens, assoreamento e redução de poços e locais de recreação, com menor valor de uso pela população local. Com relação à água, foi detectada elevada concentração de Coliformes termotolerantes, baixa concentração de oxigênio e a inviabilização da pesca. Conclui-se que as técnicas escolhidas complementam-se positivamente. O complexo mapa de diagnóstico apresentado aqui reúne dentro de si todos os resultados do Estudo de Caso. Usar mapas conceituais no processo de redução de dados permite a identificação visual dos temas e padrões, conforme observaram-se os padrões culturais para uso da água em Pirenópolis. Constatou-se que o DPSIR aumenta a eficácia de uso dos mapas conceituais, tornando-os mais robustos e relevantes, uma vez que ele orienta e auxilia a escolha dos elementos a serem incluídos no mapa conceitual; direciona o mapa para uma grande e complexa cadeia de causalidade; explicita a visualização de onde e como a dimensão humana se integra e interfere no estado do ecossistema. Somando tudo, torna mais objetiva a construção dos mapas conceituais, visando a aplicação direta no exercício de gestão participativa

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25

Follett, Stephen James. "A computational model of learning in Go". Thesis, University of South Wales, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343412.

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26

Zheng, Lingyu. "Estimation of the linkage matrix in O-GARCH model and GO-GARCH model". Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/102486.

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Statistics
Ph.D.
We propose new estimation methods for the factor loading matrix in modeling multivariate volatility processes. The key step of the methods is based on the weighted scatter estimators, which does not involve optimizing any objective function and was embedded with robust estimation properties. The method can therefore be easily applied to high-dimensional systems without running into computational problems. The estimation is proved to be consistent and the asymptotic distribution is derived. We compare the performance with other estimation methods and demonstrate its superiority when using both simulated data as well as real-world case studies.
Temple University--Theses

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Veiga, Aldrei Marucci. "Calibração do modelo hidrossedimentológico SWAT na bacia hidrográfica do córrego Samambaia, Goiânia - GO". Universidade Federal de Goiás, 2014. http://repositorio.bc.ufg.br/tede/handle/tede/3497.

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Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG
This research paper focus on the analysis of SWAT model calibration in terms of flow and sediment in Samambaia River Basin, a small watershed (32.78 km2) located at Goiânia, Brazil. Streamflow and suspended sediment daily measurements have been carried out by February to December 2013 and climatic data were obtained form a weather station located inside the basin. Terrain data such as Digital Elevation Model (DEM), soil types, and land use were on the SWAT autocalibration too as well as on SWAT-CUP software, which is a specific too for automatic calibration. Initially, the simulation run in SWAT overestimated values of runoff peak and underestimated minimum discharges. However, the peaks were minimized and minimum discharges were adjusted to the observed flows after sensitivity analysis. By using different optimization schemes (GLUE, PARASOL and SUFI-2) in SWAT-CUP, an automatic calibration analysis has been done, which presented a better fit to the observed values (start with streamflow, than move to sediment). Statistical analysis using the coefficient of Nash-Sutcliff efficiency (COE) resulted in 0.80 and 0.88 for runoff and suspended sediment, respectively, which are considered good fits between simulated and observed values. The CN parameter, which is related to soil type, land use, and infiltration, showed the highest sensitivity in the calibration. After that, the alpha factor of base flow was another which showed higher sensitivity. The higher value obtained for the Manning roughness coefficient allows runoff to be damped. With regard to sediment calibration, parameters of sediment from landscape (USLE_P and USLE_C) as well as parameters of sediment from channel (SPCON and SPEXP) have been used in the calibration, once that they have shown higher sensibility.
O objetivo desta pesquisa é fazer a análise da calibração do modelo SWAT em termos de fluxo e sedimentos na bacia do Córrego Samambaia, uma microbacia (32,78km2), localizada em Goiânia, Brasil. Medições diárias de vazões e sedimentos foram realizadas em Fevereiro a Dezembro de 2013, e os dados climáticos foram obtidos a partir de uma estação meteorológica localizada no interior da bacia. Dados do terreno, tais como Elevação Digital do Terreno (MDT), tipos de solos e usos da terra foram obtidos do Sistema de Informação e Estatística de Goiás (SIEG). Análises foram realizadas na ferramenta autocalibração do SWAT, bem como no software SWAT-CUP, que é uma ferramenta específica para a calibração automática. Inicialmente, a execução da simulação no SWAT superestimou os valores de pico do escoamento e subestimou as vazões mínimas. No entanto, os picos foram minimizados e as vazões mínimas foram ajustadas para os fluxos observados após análise de sensibilidade. Ao utilizar diferentes esquemas de otimização (GLUE, ParaSol e Sufi-2) no SWAT-CUP, uma análise de calibração automática foi feito, que apresentou um melhor ajuste aos valores observados (começando pela vazão a qual altera o sedimento). A análise estatística do coeficiente de eficiência de Nach-Sutcliffe (COE) resultou em 0,80 e 0,88 para o escoamento superficial e sedimentos em suspensão, respectivamente, que são considerados bons ajustes entre os valores simulados e observados. O parâmetro CN, que está relacionado com o tipo de solo, uso da terra e infiltração, apresentou maior sensibilidade na calibração. Depois disso, o fator alfa de fluxo de base foi outra que mostrou maior sensibilidade. Quanto maior for o valor obtido para o coeficiente de rugosidade de Manning permite que o escoamento seja amortecido. No que diz respeito a calibração dos sedimentos, os parâmetros de sedimentos de paisagem (USLE_P e USLE_C), bem como os parâmetros de sedimentos a partir do canal (SPCON e SPEXP) tem sido utilizados na calibração, uma vez que eles mostraram maior sensibilidade.

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28

VEIGA, Aldrei Marucci. "Calibração do modelo hidrossedimentológico SWAT na bacia hidrográfica do Córrego Samambaia, Goiânia - GO". reponame:Repositório Institucional da CPRM, 2014. http://rigeo.cprm.gov.br/xmlui/handle/doc/1766.

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A produção de sedimentos caracteriza-se como uma das importantes variáveis que precisam ser determinadas em bacias hidrográficas. Para um efetivo controle de erosão, é necessário avaliar os fatores que interagem na degradação do solo e da água. Na hidrologia, o entendimento do balanço hídrico é de suma importância uma vez que é a força primária que controla a dinâmica do transporte de sedimentos e nutrientes. O objetivo deste trabalho é realizar análises de calibrações do modelo hidrossedimentológico Soil Water Assessment Tool (SWAT) em termos de vazão e sedimento em suspensão na Bacia Hidrográfica do Córrego Samambaia para estimar a produção de sedimento na bacia. Foram realizadas medições de vazões e sedimentos em suspensão durante o período de Fevereiro a Dezembro de 2013 e os dados climáticos foram obtidos da estação meteorológica localizada na Escola de Agronomia da UFG. Os dados do terreno tais como o Modelo Digital de Elevação (MDE), tipos de solo e uso e ocupação do solo foram adquiridos no site do Sistema de Informação e Estatística de Goiás (SIEG). A análise estatística pelo Coeficiente de Eficiência de Nash-Sutcliffe – COE, resultou em 0,80 e 0,88 para o escoamento superficial e sedimento em suspensão, respectivamente, sendo considerados bons ajustes entre os valores medidos e simulados. Após a calibração pode-se verificar que a maior parte da produção de sedimento está nas sub-bacias próximas ao exutório da bacia do Córrego Samambaia, e observa-se que onde há glebas com vegetação remanescente ocorre redução de sedimento, e o contrário acontece nas áreas com predominância de urbanização e pastagem. As análises de calibração foram realizadas no próprio software SWAT (interface ArcSwat) e no software SWAT-CUP, que é uma ferramenta específica para calibração automática. Inicialmente, a simulação no SWAT apresentou valores superestimados nos picos de escoamento superficial e subestimou as vazões mínimas. Entretanto, e após a análise de sensibilidade, os picos foram minimizados e as vazões mínimas apresentaram valores mais ajustados aos valores medidos. No SWAT-CUP foram utilizadas as técnicas de GLUE, PARASOL e SUFI-2, sendo que o último apresentou melhor ajuste aos valores medidos. O parâmetro Cn2 (CN do método de curva número do SCS) foi o que apresentou maior sensibilidade na calibração e está relacionado ao tipo de solo, uso e cobertura do solo de acordo com a taxa de infiltração, textura e estrutura. Posterior ao parâmetro Cn2, o fator alfa do fluxo de base foi outro que apresentou maior sensibilidade. O elevado valor obtido para o coeficiente de Manning permite que o escoamento superficial seja amortecido. Assim, e levando em consideração as três variáveis de decisão mais sensíveis para descarga líquida, os resultados do modelo evidenciaram as características físicas do solo, tanto para o CN quanto para o retorno do fluxo de base, e a cobertura deste pela restrição à velocidade do escoamento através do elevado coeficiente de rugosidade obtido nas simulações.

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Shiburi, Piet Thapedi. "Tshekatsheko ya diteng le poloto ya Go ša Baori ka D.P.S. Monyaise". Diss., University of Pretoria, 2007. http://hdl.handle.net/2263/26561.

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A representative example of Monyaise’s work is his novel Go ša Baori, published in 1970. A survey of the literature reveals that this novel has already been investigated, by Malope R.M and (1986), Shole J. S.S (1988) who analysed only the dream found in this novel. The chief aim of this investigation is thus to critically analyse the structure of the novel Go ša Baori at the level of content and plot, using two research methods, namely definition and interpretation, within the context of an adapted narratological model. This model conceives of a text according to three levels, namely content, plot and style, and focuses on the topic of the content, the theme of the plot and the atmosphere of the style. Thus this research study differs from the two previous investigations of Go ša Baori because it focuses on the content level of the text by examining the topic, and the plot level by analysing the theme. The content of a text is coordinated by the topic to form a unified entity. The topic of the novel we are investigating is reflected in its title, namely Go ša Baori. The topic is thus of vital importance, and determines the arrangement and presentation of four important elements of content, namely character, time, place and events. These four elements are examined in more detail. The characters of the novel can be grouped into two categories, namely kind-hearted person (Olebile) and quarrelsome person (Wapeipi). These two content characters are investigated using the concepts of intention, patronage, resistance, assistance and success. Time and place together fall under setting. Setting can be defined as the natural and artificial environment in which characters in literature live and move (Roberts 1982:1).Time is then the period in which the events of the plot happen, and the order in which they happen. This can be expressed in various units, for example a day, month or year. Place denotes the geographical and topological position in which the characters in the story are situated and the events of the plot take place. Bal (1985: 8) regards the place within which the characters find themselves as the ‘frame’. The last of the four elements, the events, together make up the plot of the drama, which Strachan (1988: 20) and Magapa (1997: 11) describe as the second level of the text. Here theme is the key. The theme of the novel Go ša Baori centres on jealousy and competitive spirit. The plot is examined by focusing on the special functions in the plot of the protagonist Olebile and the antagonist Wapeipi, and the events related to them are classified as representing either good or evil. This study of Go ša Baori not only reveals how Monyaise creates his characters but also how he selects and shapes them for the purpose of dramatizing human life with all its varied manifestations. The actions that take place reveal essential character traits of the various characters, as do the words of the author as he describes Wapeipi as someone who makes up his mind at once and he is prepared to be hurt emotionally. While on the other hand, Olebile is a soft spoken man and very loving who shows his love to his fiancée by buying her a big diamond ring. The plot is then examined according to the conflicts that occur in its various stages, namely the exposition, the development, the climax and the denouement. There are twelve distinct conflicts that can be identified occurring between characters in the events of the plot. Monyaise using three techniques, namely repetition, elision and motif, presents the events of the exposition, which form the first conflict that sets the plot going. In the development, several other techniques are used to show the conflicting forces of character and events and to emphasize the message of the novel. The other conflicts, which are between other characters like the helpers, can be described as medium, and are not examined in great detail, though they are vital for creating suspense. In the climax phase the techniques of focus, idioms and motif are examined, particularly in the conflict between the protagonist and the antagonist, which leads to the death of the protagonist caused by emotions and complications. The conflict in the denouement phase is characterised by a very important technique, shadow to strengthen the theme of Go ša Baori. Here Monyaise uses this important technique, to strengthen the presentation of the theme of Go ša Baori. Overall, the most frequently used techniques are repetition, motif, idioms, elision, focus, rhetorical questions and foreshadowing. This novel can be classified as a tragic novel, because at the end, the antagonist dies. Using this tragic ending, Monyaise tries to caution his audience against jealousy and a competitive spirit. Thus it is the theme that holds the audience to the end of the novel.
Dissertation (MA (African Languages))--University of Pretoria, 2007.
African Languages
MA (African Languages)
unrestricted

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Lima, Ana Paula Gonçalves de. "Patrimônio arqueológico de Serranópolis - GO: reflexões para a busca de uma tutela compartilhada e efetiva". Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/71/71131/tde-29082016-151736/.

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A análise dos mecanismos jurídicos que regem, na atualidade, a arqueologia brasileira norteia este trabalho. No entanto, seu esforço central é a busca de um modelo de tutela efetiva e compartilhada para o patrimônio arqueológico existente no município de Serranópolis, região sudoeste do estado de Goiás, Brasil. Como proposta para a proteção dos sítios arqueológicos do nominado município, foi elaborado um Plano de Medidas a ser implantado pelo governo municipal, com a colaboração efetiva da comunidade e a participação dos entes públicos estadual e federal, cada um no escopo de suas competências. O presente trabalho foi desenvolvido dentro do Programa de Doutorado em Arqueologia do Museu de Arqueologia e Etnologia da Universidade de São Paulo - MAE/USP, na Linha de Pesquisa \"Arqueologia e Ambiente\".
The analysis of legal mechanisms that rule, currently, the Brazilian archeology guides this work. However, its central effort is the searching for an effective and shared guardianship model to the archaeological heritage in Serranópolis city, located in the southwest region of the state of Goiás, Brazil. As a proposal for the protection of archaeological sites in the said city, it was elaborated a Archaeological Cultural Park Project to be implemented by the Serranópolis\' municipal government, with active cooperation of the community and the participation of state and federal governments, each one in their own competences. This thesis was developed in the scope of the Archaeology Doctoral Program of Museum of Archaeology and Ethnology of University of São Paulo - MAE / USP, in the Research Field \"Archaeology and Environment\".

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Silva, Bruna Ferreira da. "Análise dos parâmetros do modelo hidrossedimentológico SWAT na bacia hidrográfica do Córrego Samambaia, Goiânia- GO". Universidade Federal de Goiás, 2015. http://repositorio.bc.ufg.br/tede/handle/tede/5154.

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Hydrological models have been a enough useful tool to management and decision-making support in river basin water resources planning since they are able to reproduce discharges and transport of sediments as well as to simulate different scenarios of land use and water quality. The main objective of this study is to perform the hydrossedimentological modeling of the Samambaia river basin Stream by applying the software SWAT. The study area is located in the north of the city of Goiânia and it has undergone an intense process of urbanization. Daily discharges and suspended sediment concentrations data were collected during 18 months in a specific section of the stream. The monitored data set has been used to analyze the influence of distinct parameters in the SWAT model adjustment. The results of the sensitivity analysis showed the parameters of soil evaporation compensation factor (Esco), threshold depth of water in the shallow aquifer required for return flow to occur (Gwqmn), available water capacity (Sol_Awc) and the depth of the soil layer (Sol_Z) as the most sensitive to simulations in terms of discharge, and the management practices and soil conservation parameter (Usle_P) to simulations in terms of suspended sediment concentrations. Best settings obtained for the precision statistics (Nash-Sutcliffe Coefficient - COE) were of 0.56 to 0.72 for calibration in terms of discharges and of 0.56 to 0.69 for calibration in terms of suspended sediment. The performance showed that the simulation with SWAT was adequate in relation to researches conducted in Brazil, whose values for model indicators are quite similar.
O uso de modelos hidrológicos tem sido uma alternativa bastante explorada para o planejamento e a tomada de decisão relacionados ao gerenciamento de bacias hidrográficas, por possibilitarem a estimativa de vazões, transporte de sedimentos e simulação de cenários sobre o uso do solo e qualidade da água. O principal objetivo deste trabalho é realizar a modelagem hidrossedimentológica da bacia hidrográfica do Córrego Samambaia por meio da aplicação do modelo SWAT. A área de estudo localiza-se na região norte da cidade de Goiânia e vem passando por um processo de urbanização intenso. Foram monitorados, durante 18 meses, vazões e concentração de sedimentos em suspensão diários em uma seção no curso d’água. Tais dados foram utilizados para a análise da influência de distintos parâmetros no ajuste do modelo SWAT. Os resultados da análise de sensibilidade apontaram que parâmetros de fator de compensação da evaporação do solo (Esco), profundidade limite de água no aquífero raso para ocorrer o fluxo de retorno (Gwqmn), capacidade de água disponível (Sol_Awc) e a profundidade da camada do solo (Sol_Z) como os mais sensíveis para as simulações em termos da vazão, e a prática de manejo e conservação do solo (Usle_P) para as simulações com ajuste em termos da concentração de sedimentos em suspensão. Os melhores ajustes obtidos nas estatísticas de precisão (Coeficiente de Nash-Sutcliffe - COE) foram de 0,56 a 0,72 para as simulações em termos da vazão e de 0,56 a 0,69 para as simulações em termos do sedimento em suspensão. O desempenho permitiu concluir que a simulação com o SWAT foi adequada em relação às pesquisas que têm sido realizadas no Brasil, cujos valores obtidos para os indicadores são semelhantes.

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32

Barbosa, Inara Oliveira. "Modelo de depósito do complexo máfico-ultramáfico de Niquelândia, GO, com base em dados multitemáticos". reponame:Repositório Institucional da UnB, 2012. http://repositorio.unb.br/handle/10482/11972.

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Tese (doutorado)—Universidade de Brasília, Instituto de Geociências, 2012.
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A integração de dados multitemáticos por meio de geotecnologias têm sido de fundamental importância no mapeamento geológico e definição de modelos de distribuição de depósitos minerais. No caso específico de ambientes mineralizados, objeto do estudo, que apresentam associação de exposição de rochas com suas coberturas superficiais intempéricas, não existe um modelo padronizado a ser utilizado na distribuição espacial das áreas mineralizadas, em função da grande variabilidade que pode ocorrer na geologia, geomorfologia e nas condições de pedogênese e enriquecimento mineral associado aos processos de alteração. Assim, o objetivo desse trabalho foi à correlação de dados aerogeofísicos (magnetométricos e gamaespectrométricos), com relevo, solos e geologia na individualização do Complexo Máfico-Ultramáfico de Niquelândia, GO e de suas unidades adjacentes, bem como gerar um mapa de favorabilidade do depósito do níquel laterítico na porção ultramáfica desse Complexo. Foi criado um banco de dados georreferenciados com informações disponíveis sobre geologia, geomorfologia, solos, dados aerogeofísico e de imagem do sensor ASTER. As feições do relevo foram geradas por meio do Modelo Digital do Terreno (MDT) extraído dos dados do Shuttle Radar Topography Mission (SRTM), sendo dele derivados os mapas de classes declividade, hipsométrica e curvatura, que constituem as feições do relevo que condicionam a formação da mineralização pedogenética de níquel. Os dados aerogeofísicos de magnetometria e gamaespectrometria foram extraídos do levantamento aerogeofísico de Goiás do Projeto “Paleo-neoproterozóico do Nordeste de Goiás”. Com os dados aerogeofísicos (magnetometria e gamaespectrometria) foram gerados dois Índices Máficos (IM) o primeiro do Complexo Máfico-Ultramáfico de Niquelândia e o segundo do depósito de níquel laterítico no município de Niquelândia. Com a imagem de satélite do sensor ASTER foi realizado a razão de +bandas para destacar as áreas ricas em Fe³ e o emprego Modelo Linear de Mistura Espectral (MLME), na identificação de áreas com concentração de minério de níquel oxidado (goethita e hematita) e minério de níquel silicatado (pimelita), com a utilização da biblioteca espectral criada com as amostras dos minérios oxidado e silicatado e solos. Com esses dados processados foi realizado duas abordagens distintas de análise espacial na área de estudo. A primeira foi à individualização do Complexo Máfico-Ultramáfico de Niquelândia de suas unidades geológicas adjacentes por meio do estabelecimento de domínios gamaespectrométricos e magnetométricos associados aos dados de relevo, geologia e solos. A segunda com a geração do mapa de favorabilidade e definição de um modelo descritivo do depósito de níquel laterítico na porção ultramáfica do Complexo de Niquelândia. Os métodos utilizados para geração dos mapas de favorabilidade foram as lógicas booleana e fuzzy. A definição do primeiro Índice Máfico (IM) permitiu a delimitação dos corpos máficos e ultramáficos, eliminando a influência da cobertura pedológica e o segundo Índice Máfico (IM) possibilitou a individualização do depósito de níquel laterítico nas rochas ultramáficas do Complexo. A utilização de imagem do sensor ASTER possibilitou a delimitação de áreas enriquecidas em níquel no minério oxidado, no minério silicatado e nos solos. A correlação com os dados aerogeofísicos, geológicos, relevo e solo permitiu caracterizar e individualizar o Complexo Máfico-Ultramáfico de Niquelândia das suas unidades geológicas adjacentes, constituídas por litologias distintas. O modelo estabelecido e os mapas de favorabilidade de mineralização de níquel no Complexo de Niquelândia, gerados pelas lógicas booleana e fuzzy apresentaram bons resultados, entretanto o fuzzy mostrou-se no mapeamento resultado superior. ______________________________________________________________________________ ABSTRACT
The integration of data from varied sources has been of fundamental importance for geologic mapping and definition of models for the distribution of mineral deposits. In the specific case of mineralized environments, object of the study, show that the association of exposure with their cover of rocks weathering surface there is no one standard model to be used in the spatial distribution of the mineralized areas, due to the large variability that can occur in geology, geomorphology and conditions of pedogenesis and mineral enrichment processes associated with change. The objective of this study was the correlation of the airborne geophysical data (gammaspectrometry and magnetometric), with relief, soils and geology in the individualization Mafic-Ultramafic Complex Niquelândia, GO, and its adjacent units, as well as generate a favorability of lateritic nickel deposit in portion of ultramafic complex. It created a georeferenced database with information available on geology, geomorphology, soils, airborne geophysical data and ASTER image. The relief features were generated by means of Digital Terrain Model (DTM) extracted data from the Shuttle Radar Topography Mission (SRTM), it being derived from the maps of slope, hypsometric and curvature classes, which constitute the relief features that, influence the formation of nickel mineralization pedogenetic. The airborne geophysical data of magnetometry and gammaspectrometry were extracted from the airborne geophysical survey of Goiás Project "of Northeastern Paleo-Neoproterozoic Goiás". With the airborne geophysical data (magnetometry and gammaspectrometry) were generated two Mafic Indexes (MI) the first Mafic-Ultramafic Complex Niquelândia and the second of nickel laterite of deposit in the city of Niquelândia. With satellite imagery ASTER was carried the reason bands to highlight areas rich in Fe³ + and employment Linear Spectral Unmixing Model (LSUM), to identify areas with concentration of nickel oxides (goethite and hematite) and nickel ore silicate (pimelite), using the spectral library created with the samples of oxidized ores and silicate and soils. With these processed data was performed two distinct approaches to spatial analysis in the study area. The first was the individualization MaficUltramafic Complex Niquelândia its adjacent geological units through the establishment of gammaspectrometric and magnetometric fields associated with data of topography, geology andvi soils. The second generation of the map with the favorability and definition of a descriptive model of nickel laterite deposit in ultramafic portion of the complex Niquelândia. The methods used to generate the maps were the favorability of Boolean and fuzzy logics. The definition of the first Mafic Index (MI) allowed the delineation of mafic and ultramafic, eliminating the influence of pedologic cover and the second Mafic Index (MI) allowed the individualization of lateritic nickel deposit in ultramafic rocks of the Complex. Using ASTER image allowed the delineation of areas enriched in nickel oxide ore, the ore and silicate soils. The correlation with the airborne geophysical data, geology, topography and soil allowed characterizing and individualizing Mafic-Ultramafic Complex Niquelândia its adjacent geologic units, consisting of different lithologies. The established model and favorability maps of nickel mineralization in complex Niquelândia, generated by Boolean logic and fuzzy showed good results, however the fuzzy proved mapping result in higher.

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Boman, Axel, i Erik Nilsson. "Go with the flow : A study exploring public transit performance using a flow network model". Thesis, Uppsala universitet, Avdelningen för systemteknik, 2020. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-415922.

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As opposed to public transit agencies' well-developed data generation capabilities, their utilization of their data is often overlooked. This study will tap into the potential of using the GTFS data format from an agency stakeholder perspective to assess transit performance. This format holds data for scheduled transit services, including real-time updates and network organization. The broad adaptation of GTFS by transit agencies (1240 transit networks in 672 locations worldwide) has made it a de-facto standard, making products built on top of it inherently scalable and could potentially be deployed in networks all over the world. The purpose of this thesis is two-fold; firstly, to explore how specific vulnerability features of nodes in a public transit network can be assessed using graph mining algorithms. Secondly, to develop a pipeline for aggregating GTFS data and fit it into a flow network model. The results include a data-driven framework for vulnerability characterization, a method for fitting GTFS data in a flow network model, and lastly, a definition for reduced flow capacity in a public transit context. Additionally, the results are presented in the setting of Uppsala's network (UL) and visualized with a web-based tool.

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Roeske, Cassandra. "Role of the Heterotrimeric Go Protein Alpha-subunit on the Cardiac Secretory Phenotype". Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/24191.

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Atrial natriuretic factor (ANF) is a polypeptide hormone produced in heart atria, stored in atrial secretory granules and released into the circulation in response to various stimuli. Proper sorting of ANF at the level of the trans-Golgi network (TGN) is required for the storage of ANF in these specific granules, and this sorting of hormones has been found to be associated with G-proteins. Specifically, the Go protein alpha-subunit (Gαo) was established to participate in the stretch-secretion coupling of ANF, but may also be involved in the transporting of ANF from the TGN into atrial granules for storage and maturation. Based on knowledge of Gαo involvement in hormone production in other endocrine tissues, protein-protein interactions of Gαo and proANF and their immunochemical co-localization in granules, the direct involvement of these two proteins in atrial granule biogenesis is probable. In this study, mice were created using the Cre/lox recombination system with a conditional Gαo knockout in cardiocytes to study and characterize ANF production, secretion and granule formation. Deletion of this gene was successful following standard breeding protocols. Characterization and validation of cellular and molecular content of the knockout mice through mRNA levels, protein expression, peptide content, electron microscopy, and electrocardiography determined that a significant phenotypic difference was observed in the abundance of atrial granules. However, Gαo knockout mice did not significantly alter the production and secretion of ANF and only partially prevented granule biogenesis, likely due to incomplete Gαo knockout. These studies demonstrate an involvement of Gαo in specific atrial granule formation.

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Rocha, Nayda. "Planejamento urbano da bacia do córrego Samambaia (Goiânia-GO) utilizando o SWMM - Storm Water Management Model". Universidade Federal de Goiás, 2013. http://repositorio.bc.ufg.br/tede/handle/tde/2927.

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Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - CAPES
The effect of urbanization and insufficient supervision of the use of natural resources by the government has led to increasing degradation of the environment in Brazil. This can be seen by the suppression of riparian vegetation, which is essential for the survival and maintenance of the quality of water sources. In this sense, the actions of development of land, housing provision and sanitation in Brazil must have, among other objectives, to ensure an environment conducive to ecosystems and human life support. This research aimed to identify the characteristics of occupation of Córrego Samambaia Basin in Goiânia, used for public water supply, correlating land use with hydrological processes. The methodology adopted consisted in: identifying the theoretical framework from literature and choose a basin to develop a case study; select and gather information from the object of study contained in published documents, restricted texts, satellite imagery, site visits, to generate the necessary data for modeling, and apply the hydrologic model Storm Water Management Model (SWMM) in three distinct periods and three proposed scenarios to understand the hydrological responses in the study area due to different levels of human occupation. The results obtained with this research indicate that the hydrological watershed responses can vary widely if the waterproofing process continue to increase. Results shown that between 1992 (with impervious area of 7%) and the proposed Scenario 3 (with impervious area of 70%) the increase in runoff is approximately 24 times while the infiltration becomes 70% smaller. If the basin achieves an index greater than 50% of impervious area, it will probably become unviable for public supply purposes. In order to preserve the watershed for its main purpose to continue supplying the municipality this study proposes an appropriated urban planning, with the construction of a Linear Park along the creek and the adoption of new levels of urban occupation. This planning model may be used in other urban basins, taking into account the characteristics of each site.
O efeito da urbanização e a insuficiente fiscalização do uso dos recursos naturais pelo poder público têm provocado crescente degradação do meio ambiente no Brasil. Isto pode ser constatado na supressão da vegetação ciliar, indispensável para a sobrevivência e manutenção da qualidade dos mananciais. Neste sentido, as ações de parcelamento do solo, provisão habitacional e saneamento no país devem ter, entre outros objetivos, o de assegurar um meio ambiente favorável aos ecossistemas e à vida humana. Esta dissertação teve como objetivo principal identificar as características de ocupação da bacia hidrográfica do Córrego Samambaia em Goiânia, utilizada para abastecimento público de água, correlacionando o uso do solo com os processos hidrológicos. A metodologia adotada consistiu em: identificar o referencial teórico a partir de pesquisa bibliográfica e escolher uma bacia para estudo de caso; selecionar e reunir informações do objeto de estudo contidas em documentos publicados, textos restritos, imagens de satélite, visitas in loco, para a geração dos dados necessários para realizar a modelagem; e aplicar o modelo hidrológico Storm Water Management Model (SWMM) em três períodos distintos e outros três cenários propostos para se conhecer as respostas hidrológicas na área de estudo frente a diferentes níveis de intervenção e ocupação urbana. Os resultados obtidos com esta pesquisa indicam que a bacia pode apresentar grandes variações hidrológicas caso o processo de impermeabilização continue aumentando. Com relação ao escoamento superficial na bacia, entre 1992 (com área impermeável de 7%) e o Cenário 3 proposto (com área impermeável de 70%) o aumento é de aproximadamente 24 vezes enquanto no mesmo período a infiltração tornou-se 70% menor. Se a bacia obtiver um índice maior que 50% de área impermeável, provavelmente irá se tornar inviável ao abastecimento público. Para que ela continue abastecendo o município, propõe-se neste estudo um planejamento urbano adequado, com a construção de um Parque Linear ao longo do córrego e a adoção de novos índices de ocupação urbana. Este modelo de planejamento poderá ser utilizado em outras bacias urbanas, levando em consideração as características de cada local.

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van, Roozendaal Lou. "Should We Stay or Should We Go? : The Influence of Rebel Governance on Rebel Fragmentation". Thesis, Uppsala universitet, Institutionen för freds- och konfliktforskning, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-445373.

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The fragmentation of rebel groups has received extensive attention from scholars and policy-makers alike. Fragmentation has been linked to an increase in civilian deaths, prolonged conflicts, and difficult peace negotiations. Despite the deliberation given to this field, this study argues that rebel governance serves as an explanatory variable that has been overlooked in the literature. This study aims to close this research gap by examining the influence of rebel governance on rebel fragmentation. The thesis suggests that rebel governance intervenes with the opportunity for rebel lieutenants to find the support of networks to create a splinter, and is successful in preventing rebel lieutenants from forming potential splinters. Therefore, it is hypothesized that rebel governance reduces the likelihood of rebel fragmentation. Using data on rebel groups active between 1946-2012, this thesis finds quantitative evidence in support of the hypothesis across all models. Furthermore, support is found that suggests that the more rebel institutions are present, the less likely it is that the rebel group fragments. Additionally, this study employs a survival model of which the results suggest that rebel groups who employ governance take longer to fragment compared to rebel groups without governance.

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37

Huber, Florian, Gregor Kastner i Martin Feldkircher. "Should I stay or should I go? Bayesian inference in the threshold time varying parameter (TTVP) model". WU Vienna University of Economics and Business, 2016. http://epub.wu.ac.at/5178/1/wp235.pdf.

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We provide a flexible means of estimating time-varying parameter models in a Bayesian framework. By specifying the state innovations to be characterized trough a threshold process that is driven by the absolute size of parameter changes, our model detects at each point in time whether a given regression coefficient is constant or time-varying. Moreover, our framework accounts for model uncertainty in a data-based fashion through Bayesian shrinkage priors on the initial values of the states. In a simulation, we show that our model reliably identifies regime shifts in cases where the data generating processes display high, moderate, and low numbers of movements in the regression parameters. Finally, we illustrate the merits of our approach by means of two applications. In the first application we forecast the US equity premium and in the second application we investigate the macroeconomic effects of a US monetary policy shock.
Series: Department of Economics Working Paper Series

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Sonntag, Mirko [Verfasser], i Dimka [Akademischer Betreuer] Karastoyanova. "Model-as-you-go - ein Ansatz zur flexiblen Entwicklung von wissenschaftlichen Workflows / Mirko Sonntag ; Betreuer: Dimka Karastoyanova". Stuttgart : Universitätsbibliothek der Universität Stuttgart, 2016. http://d-nb.info/111836967X/34.

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Mörtsell, Lisa. "Should I stay or should I go? : Developing the Narrative model as a tool for game design". Thesis, Umeå universitet, Institutionen för informatik, 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-149243.

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In 2015, the Narrative model was created as a result of a study exploring how episodic games keep player’s interests through combining narrative and gameplay. In this thesis, the Narrative model is used as a framework for designing a language game for children to see whether that makes players more inclined to keep playing than a game not designed based on the model. Two games were created and evaluated in a within subject controlled experiment. Player enjoyment was measured by using GameFlow as a basis for interview questions and Likert scales. The results indicated that the game based on the model more successfully achieved GameFlow than the game that was not. As such, it was concluded that the model can be used as a tool for game design to increase the desire to keep playing a game, but that it needs further study to be validated.

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Chamois, Sébastien. "Etude de la dégradation des ARN messagers aberrants par la voie de surveillance du No-Go Decay chez Saccharomyces cerevisiae". Electronic Thesis or Diss., Sorbonne université, 2020. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2020SORUS023.pdf.

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L’expression des gènes est un mécanisme complexe qui peut conduire à la synthèse d’ARN messagers aberrants, susceptibles de perturber l’homéostasie cellulaire. Il existe ainsi chez les eucaryotes des voies de surveillance chargées d’éliminer de tels ARN, en particulier dans le cytoplasme. Le No-Go Decay (NGD) est l’une d’entre-elles et assure l’élimination des messagers responsables de blocages des ribosomes au cours de l’élongation de la traduction. Ce mécanisme met en jeu des clivages endoribonucléolytiques qui se produisent aux abords des ribosomes bloqués sur l’ARN. La localisation précise de ces clivages, toujours débattue dans la littérature, est un élément essentiel à la compréhension du rôle joué par le NGD dans le cytoplasme. Au cours de ma thèse, j’ai étudié cette voie de surveillance à l’aide d’une construction plasmidique capable d’exprimer un ARN tronqué ciblé par le NGD. Grâce à cette approche, j’ai montré qu’une attaque endoribonucléolytique unique dépendante de Hel2 et Cue2 était responsable d’un clivage de l’ARN au niveau du troisième ribosome bloqué durant l’élongation de la traduction. Nous avons également mis en évidence que cet événement, qui intervient à 8 nucléotides en amont du site P du ribosome, produit un fragment 3’-NGD possédant une extrémité 5’-hydroxylée. Cette extrémité est par la suite phosphorylée par la kinase Trl1. Nous proposons enfin que l’élimination de cet ARN est majoritairement assurée par la voie 5’-3’ de dégradation avec l’action de Xrn1 et alternativement de Dxo1
Gene expression is a complex mechanism that can lead to the production of aberrant messenger RNA that may in turn disrupt cell homeostasis. In eukaryotes, it exists several surveillance pathways in charge of degrading such RNA in the cytoplasm. The No-Go Decay (NGD) is one of those and degrades mRNA containing stacks of stalled ribosomes. This mechanism is characterized by an endoribonuclease that initiates cleavages upstream of the stall sequence. Their precise location, still under debate in the literature, has proven crucial in the understanding of the exact role of the NGD in the cytoplasm. During my thesis, we studied this surveillance pathway, using mRNAs expressing a 3′-ribozyme to produce truncated transcripts in vivo to mimic naturally occurring truncated mRNAs known to trigger NGD. Thanks to this technique, we were able to show that a unique endonucleolytic cleavage, which we find to be Hel2 and Cue2-dependent, occurs eight nucleotides upstream of the first P-site nucleotide within the third stacked ribosome. We demonstrate that this event produces a 3’-NGD RNA, which has a hydroxylated 5’-extremity that is then 5’-phosphorylated by the Trl1 kinase. Ultimately, we suggest that 5’-3’ degradation pathway is then involved in the degradation of this RNA with the action of Xrn1 and Dxo1

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Hu, Junqi. "Estimation of Runway Throughput with Reduced Wake Vortex Separation, Technical Buffer and Runway Occupancy Time Considerations". Thesis, Virginia Tech, 2018. http://hdl.handle.net/10919/85047.

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This thesis evaluates the potential recovery of the runway throughput under Wake Turbulence Re-categorization (RECAT) Phase II and Time-based Separation (TBS) with a Runway Occupancy Time (ROT) constraint comparing with RECAT Phase I. This research uses aircraft performance parameters (runway occupancy time, approach speed, etc.) from the Airport Surface Detection Equipment, Model X (ASDE-X) data set. The analysis uses a modified version of the Quick Response Runway Capacity Model (RUNSIM). The main contributions of the study are: 1) identifying the technical buffer between in-trail arrivals and regenerate them in RUNSIM; 2) estimate the percentage of the arrival pairs that have wake mitigation separation times in excess of ROT; 3) developed an additional in-trail arrival separation rule based on ROT; 4) measure the risk of potential go-arounds with and without the additional 95 ROT separation rules. 5) generate a sample equivalent time-based RECAT II. The study results show that the distributions of technical buffers have significant differences for different in-trail groups and strong connectivity to airport elevations. This is critical to estimate runway capacities and safety issues especially when advanced wake mitigation separation rules are applied. Also, with decreasing of wake separations, ROT will become a limiting factor in runway throughput in the future. This study shows that by considering a 95 percentile ROT constrain, one single runway can still obtain 4 or 5 more arrivals per hour under RECAT II but keep the same level of potential go-arounds compared with current operation rules (RECAT I). TBS rules seem to benefit more under strong wind conditions compared to RECAT I, and RECAT II. TBS rules need to be tailored to every airport.
Master of Science

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Amorim, Mirian Castro Portilho Dias. "Um modelo de avaliação da oolítica nacional de humanização sob o prisma da eficiência: proposta a partir de estudo de caso no Hospital e Maternidade Dona Íris em Goiânia/GO". Universidade Federal de Goiás, 2018. http://repositorio.bc.ufg.br/tede/handle/tede/8557.

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Fundação de Amparo à Pesquisa do Estado de Goiás - FAPEG
The present research focused on answering the following problem question: what are the limitations found in the PNH evaluation model proposed by Santos-Filho (2014) as a starting point for local efficiency and specificities? Thus, the overall objective of the study was to elaborate for the Hospital and Maternity Dona Iris an evaluation model for the HNP, focusing on humanization in the context of the Stork Network, adding participatory elements and starting with the strategic axes of monitoring and evaluation proposed by Santos-Filho (2014), the principle of efficiency and local specificities. The methodology used can be classified as applied, descriptive, with a qualitative approach and with regard to procedures such as case study. Crossing the methodological path of pluralistic perspective, interviews were conducted with 40 pregnant women, 13 health professionals and 2 managers. The main results identified in the diagnosis were: the maternity does not carry out local assessments with a view to measuring the humanization in the context of the Stork Network; the demand for vacancies and services extrapolates the delivery capacity of maternity services, impacting on the quality of care and the humanization both for patients and for health professionals; the waiting time for care is the main negative aspect posed by pregnant women and good care is the main positive aspect mentioned; transparency, one of the values that make up the organizational identity of motherhood, has not been applied to content, since production and financial reports are outdated in electronic websites; and health professionals do not realize that humanization in HMDI applies to them. Based on the diagnosis, a proposal for an evaluation model for HNP was prepared in the context of the Stork Network containing a list of indicators, variables and keywords for each evaluation axis; a technical sheet for describing indicators; a script for interview with users and health professionals; and a list of criteria to be analyzed in the direct observation of the health professionals' performance. The study is limited because it is a case study in which its findings, in principle, can’t be generalized, requiring new studies in other maternities to assertively verify the possibility of replication of the model throughout the network. maternal and child health in the city of Goiânia.
A presente pesquisa dedicou-se a responder a seguinte pergunta-problema: tendo como ponto de partida a eficiência e as especificidades locais, quais as limitações encontradas no modelo de avaliação da PNH proposto por Santos-Filho (2014)? Assim, o objetivo geral do estudo foi elaborar para o Hospital e Maternidade Dona Íris um modelo de avaliação para a PNH, com foco na humanização no contexto da Rede Cegonha, agregando elementos participativos e tendo como ponto de partida os eixos estratégicos de monitoramento e avaliação propostos por Santos-Filho (2014), o princípio da eficiência e as especificidades locais. A metodologia utilizada pode ser classificada como aplicada, descritiva, de abordagem qualitativa e quanto aos procedimentos como estudo de caso. Percorrendo o caminho metodológico de perspectiva pluralista, foram realizadas entrevistas com 40 gestantes, 13 profissionais de saúde e 2 gestores. Os principais resultados identificados no diagnóstico foram: a maternidade não realiza avaliações locais com vistas a aferir a humanização no contexto da Rede Cegonha; a demanda por vagas e atendimentos extrapola a capacidade de entrega de serviços da maternidade, impactando na qualidade da assistência e na humanização tanto voltada aos pacientes quanto aos profissionais de saúde; o tempo de espera por atendimento é o principal aspecto negativo colocado pelas gestantes ouvidas e o bom atendimento é o principal aspecto positivo mencionado; a transparência, um dos valores que compõem a identidade organizacional da maternidade, não vem sendo aplicada a contento, uma vez que os relatórios de produção e financeiros estão desatualizados nos sítios eletrônicos; e os profissionais de saúde não percebem que a humanização no HMDI se aplica a eles. A partir do diagnóstico elaborou-se uma proposta de modelo de avaliação para a PNH no contexto da Rede Cegonha contendo um rol de indicadores, variáveis e palavras-chave para cada eixo de avaliação; uma ficha técnica para descrição dos indicadores; roteiro para entrevista com usuárias e profissionais de saúde; e uma lista de critérios para serem analisados na observação direta da atuação dos profissionais de saúde. O estudo limita-se por se tratar de um estudo de caso em que os seus achados, a princípio, não podem ser generalizados, necessitando de novos estudos em outras maternidades para verificar de forma assertiva a possibilidade de replicação do modelo em toda a rede de saúde materno- infantil do município de Goiânia.

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Börjeson, Mauritz, i Andreas Pettersson. "Moving from Practice toward Science : Defining Go-To-Market model and setting it up to turn potential into profit". Thesis, Umeå University, Umeå School of Business, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-26476.

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Firms are today struggling with setting up successful go-to-market models. Go-to-market (GMT)expenses are reported to be a considerable part of company spending, but in many cases withoutyielding enough return. This case study investigated the concept of go-to-market models and howcompanies successfully can set it up to turn potential into profit. Atea was struggling with setting up their go-to-market model for Midmarket in Stockholm for their Product/volume offering and their dilemma constituted a great opportunity for expanding the relative young field of GTM research.

The problem was approached using an abductive research strategy. The study moved back and forth between theory and empirical data gathered primarily by in-depth and semi-structured interviews with managers at high level in Atea. The nature of the GTM concept was thoroughly examined including its relation to other parts of the organization and the assumptions about underlying economics. Structure throughout the whole research process was achieved by thematization of the problem and methodological adherence.

Merging the empirical findings with existing theory resulted in the first holistic definition of model successfully connects the different components of the GTM-model with each other. Relevant theories are connected to the framework as aid for using the concept as a tool for analysis.

Our findings show that the GTM-model should be an extension of the marketing strategy and the overall business strategy. When setting up a GTM-model it is therefore crucial that the setup has its roots in the overall strategy of the company to ensure a setup that is consistent with the go-tomarketthat relates the concept to overall strategy and marketing strategy. Itcompany’s brand promise. The GTM-model itself is constructed from four main areas; GTM-strategy, segmentation, channel choices and systems and support. GTM-strategy concerns aligning the GTM setup with the overall firm and marketing strategies but also setting priorities based on the underlying economics of target clients as well as priorities based on market data of what are the driving factors of those underlying economics. The segmentation must all available data and should be based on variables of customer needs in terms of problems, buying behavior or desired customer experience. The channels have to reflect the potential of the client and a model has been developed for prioritizing channel choices. The channel choices also depend on the product or service the company is taking to the market. Finally the supporting functions need to have a lean set-up where focus is on cost efficiency while providing the core functions with the support they need. The support function should be responsible for tracking the data required to assess the underlying economics. The four distinct parts are closely integrated and changes in one part will have implications in the other parts.

For Atea a series of actions were developed to improve their performance and profitability of their GTM-model for their Midmarket in Stockholm. The findings of this case study are transferable to the other regions of Atea Sweden but also to other companies within the same industry. The generic concept definition of GTM model is transferable beyond this limit to include all complex business but further research has been suggested to validate these findings. The building blocks and relative importance of the four parts will vary from industry to industry, and from company to company, with regard to the unique capabilities of each specific case.

The model is the first holistic model of the GTM concept that puts the GTM-model in the context of the whole company and provides a definition to avoid concept confusion while being a practical framework to use for analysis. It will therefore be of help to both practitioners setting up successful GTM-models and to researcher of the field of GTM strategy and GTM models.

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Griffin, Graeme. "The mouse vas deferens as an in vitro model for elucidating the modes of action of cannabinoids". Thesis, University of Aberdeen, 1996. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU543696.

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The suitability of the electrically stimulated mouse isolated vas deferens for the study of cannabinoid receptor ligands was investigated. Cannabinoid receptor agonists produced a concentration-related inhibitory effect on the contractile response of the vas deferens, demonstrating high potency, chemical- and stereo-selectivity. An endogenous cannabinoid receptor ligand, anandamide, was also found to share this inhibitory activity. The potency of the agonists correlated positively with binding affinity at CB 1 receptors and with potency in reducing spontaneous activity in the mouse in vivo. This suggested a receptor-based mode of action for the action of cannabinoid receptor agonist in this model. In order to overcome the non-specific nature of this inhibitory effect of cannabinoid receptor agonists, vasa deferentia were made tolerant to the inhibitory effects of Delta9-tetrahydrocannabinol (THC) by in vivo pretreatment with THC. This tolerance extended to other cannabinoid receptor agonists, synthetic and endogenous, but not to a number of non-cannabinoid twitch inhibitors. This tolerance did not involve a change in the sensitivity of the tissue to noradrenaline or a stable ATP analogue, beta-gamma-methylene-L-ATP (L-AMP-PCP) when exogenously applied. The degree of this tolerance was of the order of a 10 - 30 fold rightward shift of dose response curves, and the duration was greater than 10, but less than 30 days. In conclusion, the electrically stimulated mouse isolated vas deferens appears to be a suitable bioassay for the functional study of cannabinoid receptor ligands acting at CB1 receptors. This model may also be applicable to investigations into the mechanisms of action of cannabinoid tolerance. Pilot studies also demonstrated the possible use of this bioassay for the study of CB2-selective cannabinoid receptor ligands.

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Palmieri, Matheus. "Modelo geológico e avaliação de recursos minerais do depósito de nióbio Morro do Padre, complexo alcalino-carbonatítico Catalão II, GO". reponame:Repositório Institucional da UnB, 2011. http://repositorio.unb.br/handle/10482/12432.

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Dissertação (mestrado)—Universidade de Brasília, Instituto de Geociências, Programa de Pós-Graduação em Geociências Aplicadas, 2011.
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O depósito de nióbio do Morro do Padre, no Complexo Alcalino Carbonatítico Catalão II, foi descoberto na década de 80, porém até 2005 nenhum trabalho representativo havia sido feito para melhor caracterizar a mineralização ali presente. Com as campanhas de sondagem de 2005 a 2010, foi possível realizar a modelagem geológica e econômica tanto da porção alterada quanto da primária do depósito. Técnicas de geoestatística foram utilizadas para entender espacialmente as distribuições das diferentes populações presentes na área. Os dados de geoquímica exploratória foram interpolados por krigagem ordinária para obter teores estimados ao longo de todo o volume mineralizado. Análises químicas de rocha total e dados de química mineral de pirocloro, bem como estudos mineralógicos e texturais em testemunhos de sondagem e lâminas delgadas polidas auxiliaram na definição de tipos litológicos e evolução magmática do minério primário. Dados mineralógicos e texturais do solo desenvolvido sobre o minério primário, obtidos por microscopia eletrônica e difratometria de raios-x permitiram compreender a distribuição, estrutura e variações do minério supergênico. A modelagem das diferentes rochas e dos corpos mineralizados apoiada nessas informações permitiu estabelecer a geometria, relações de contato e evolução tanto das rochas quanto dos minérios primário e supergênico do depósito de nióbio do Morro do Padre. O depósito pode ser dividido em três zonas, Superior, Intermediária, e Inferior, sendo que a primeira corresponde ao minério supergênico, coincidente com o manto de intemperismo, e as outras duas a distintos domínios da mineralização em rocha fresca (minério primário). A zona superior, ou manto de intemperismo, foi modelada levando em consideração os diferentes níveis intempéricos, representados por variações mineralógicas, como o minério caulinítico-oxidado, minério do tipo silcrete, e minério micáceo. A relação direta entre o solo e a rocha é evidenciada pelas zonas estéreis intercaladas com zonas mineralizadas no solo tal qual na rocha fresca. O minério supergênico tem um fator de enriquecimento residual de nióbio de cerca de 30% devido à lixiviação principalmente dos carbonatitos.A porosidade dos solos desenvolvidos sobre as rochas intrusivas facilitou a percolação de fluidos durante o intemperismo, o que levou à formação de níveis de silcrete, preferencialmente sobre as regiões de minério mais rico. A profundidade destes níveis é controlada pela interface entre o minério caulinítico-oxidado e o minério micáceo, que representa uma superfície de contraste de permeabilidade. O envelope mineralizado no solo tem orientação principal E-W, possui cerca de 70 metros de profundidade, 475 metros de comprimento na direção leste-oeste, e 100 metros de largura na direção norte-sul e totaliza 2.981.000 toneladas com teor de 1,69 % Nb2O5. A rocha fresca foi dividida em duas zonas. A zona intermediária, sotoposta à zona superior, consite de enxame de diques de apatitanelsonito (N1), calciocarbonatito (C1), pseudonelsonito (N2) e magnesiocarbonatito (C2),encaixados em fraturas nos filitos e anfibolitos fenitizados do Grupo Araxá. Nesta zona predominam rochas das unidades N2 e C2, as quais estão espacial e geneticamente relacionadas, uma vez que os pseudonelsonitos N2 formam-se como cumulados nas paredes dos diques de magnesiocarbonatito C2. A geometria dessa zona varia com a profundidade. Nas porçoes mais profundas, os enxames de diques de nelsonito e carbonatito estão concentrados em uma faixa estreita, que se alarga em direção à superfície. Tal comportamento está provavelmente relacionado com a diminuição da pressão litostática nos níveis superiores, permitindo a ocorrência de um maior número de fraturas abertas por onde os magmas carbonatítico e, em menor intensidade, nelsonítico, puderam percolar. A zona inferior consiste de um sill ou pequena câmara acamadada,onde ciclos sucessivos e rítmicos mostram a evolução dosnelsonitos N1 para os calciocarbonatitos C1 por cristalização fracionada a partir de um magma original nelsonítico. O depósito de nióbio de rocha fresca, isto é zona intermediária somada à zona inferior, possui 11.518.000 toneladas de recursos de nióbio com teor de 1,48 % de Nb2O5. O montante total de recursos de nióbio no depósito Morro do Padre (medido+indicado+inferido em minério primário + minério residual) é de 14.499.000 toneladas, a 1,52 % Nb2O5. _________________________________________________________________________________ ABSTRACT
The Morro do Padre Nb deposit, in the Catalão 2 alkaline-carbonatite complex was discovered in the 80's, but detailed exploration was not undertaken in this deposit until 2005. Extensive drilling campaigns from 2005 to 2010 made it possible to model both the supergene and primary domains of the deposit from the geological and economic point of views. Geostatistics techniques were employed to understand the spatial distribution of the several populations present in the area. Geochemical exploration data were interpolated by ordinary krigging in order to estimate Nb grades throughout the ore. Whole-rock chemistry, pyrochlore mineral chemistry, and mineralogical and textural studies on drill cores and thin sections, helped to define the lithological types and magmatic evolution of the primary (fresh-rock) ore. The mineralogy and textures determined for the soil cover by means of electron microscopy and X-ray diffractometry allowed the understanding of the distribution, structure and variations in the supergene (residual) ore. The modeling of the various rock-types and ore-bodies supported by these data lead to establish the geometry, contact relationships and evolution of the igneous rocks, as well as of the primary and secondary ore. The deposit may be subdivided into an upper, intermediate, and lower zones. The first corresponds to the supergene ore, whilst the two later are represented by distinct domains of the primary ore. The upper zone was modeled taking into account the various levels of weathering intensity, represented by mineralogical changes: kaolinite-oxide ore, silcrete ore, and micaceous ore. A direct relatioship between the soil and the fresh rock is depicted by the intercalations of ore and barren vertical bodies that represent the extension of the fresh rock ore bodies into de soil. The supergene ore shows an Nb enrichment factor of ca. 30% due to the leaching of soluble componentes, especially from the altered carbonatites. The high porosity of the soil over the alkaline intrusive rocks (particularly nelsonites) favored the infiltration of meteoric waters, leading to the formation of silcrete crusts preferably from the higher-grade ore. The depth of such silcrete levels is controlled by the limit between the kaolinite-oxide ore and the micaceous ore, since this represents a permeability contrast limit. The ore envelope within the soil cover is elongated E-W, has 70 meters in depth, 475 meters E-W, 100 meters N-S and contains total resources of 2.981 Mt @ 1.69 % Nb2O5. The fresh rock was subdivided in two separate zones (intermediary and lower). The intermediary zone underlies the soil cover and is characterized by dike swarms of apatite-nelsonite (N1), calciocarbonatite (C1), pseudonelsonite (N2) and magnesiocarbonatite (C2), intruded in fenitized phyllites and amphibolites of the Precambrian Araxá Group. This zone is dominated by N2 and C2 rocks, which are geographically and genetically associated, since N2 pseudonelsonites precipitate as cumulates on the walls of the C2 magnesiocarbonatites. The geometry of the intermediary zone varies from a narrow zone with nelsonite and carbonatite dike swarms in deeper levels to a wider zone towards the surface, probably due to the decrease in lithostatic pressure, thus leading to a larger number of open fractures through which the magmas (particularly carbonatite, less so nelsonite) were able to percolate. The lower zone consists of a rhythmically layered sill or small magma chamber, where successive cycles of differentiation and magma replenishment show that the N1 nelsonites evolved to the C1 calciocarbonatites by fractional crystallization. The Nb resources in fresh rock (i.e. Intermediate Zone + Lower Zone) amount to 11.518 Mt @ 1,48 % Nb2O5. The total Nb resources of the deposit (measured + indicated + inferred; primary + secondary ore) is 14.499 Mt @ 1,52 % Nb2O5.

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Banks, Russell K. "Annotation Tools for Multivariate Gene Set Testing of Non-Model Organisms". DigitalCommons@USU, 2015. https://digitalcommons.usu.edu/etd/4515.

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Many researchers across a wide range of disciplines have turned to gene expression anal- ysis to aid in predicting and understanding biological outcomes and mechanisms. Because genes are known to work in a dependent manner, it’s common for researchers to first group genes in biologically meaningful sets and then test each gene set for differential expression. Comparisons are made across different treatment/condition groups. The meta-analytic method for testing differential activity of gene sets, termed multi-variate gene set testing (mvGST), will be used to provide context for two persistent and problematic issues in gene set testing. These are: 1) gathering organism specific annotation for non-model organisms and 2) handling gene annotation ambiguities. The primary purpose of this thesis is to explore different gene annotation gathering methods in the building of gene set lists and to address the problem of gene annotation ambiguity. Using an example study, three different annotation gathering methods are proposed to construct GO gene set lists. These lists are directly compared, as are the subsequent results from mvGST analysis. In a separate study, an optimization algorithm is proposed as a solution for handling gene annotation ambiguities.

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Coral, Gustavo. "Utilização de modelo agrometeorologico na estimativa de produtividade da cultura da soja, nos estados de GO, MT, PR, RS e SP". [s.n.], 2004. http://repositorio.unicamp.br/jspui/handle/REPOSIP/257142.

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Orientadores: Hilton Silveira Pinto, Maria Angela Fagnani
Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Engenharia Agricola
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Resumo: A agricultura é a atividade econômica mais afetada pelo clima. Os fenômenos meteorológicos como a temperatura, precipitação, umidade relativa, velocidade do vento, influenciam tanto na produtividade e qualidade dos produtos agrícolas, quanto nos custos de produção. Uma das ferramentas mais utilizadas para quantificar os efeitos causados pelos fenômenos meteorológicos na produtividade agrícola são os modelos agrometeorológicos. No presente trabalho foi utilizado um modelo agrometeorológico multiplicativo, que se baseia na penalização da produtividade agrícola, em decorrência de fenômenos meteorológicos desfavoráveis ao desenvolvimento da cultura, para a estimativa de safra da soja. O estudo abrangeu um total de 66 municípios nos estados de Goiás, Mato Grosso, Paraná, Rio Grande do Sul e São Paulo. Foram relacionados os municípios que possuíam área plantada de soja superior à 2000 ha, com os municípios que possuíam estações pluviométricas operando entre os anos de 1994à 2000. Utilizou-se mapas pedológicos para diferenciação dos tipos de solos predominantes em cada município, com a finalidade de se obterem informações sobre a capacidade de água disponível no solo (CAD), bem como a média histórica da evapotranspiração potencial (ETP) para o cálculo do balanço hídrico decendial e da evapotranpiração real (ETR). As épocas de semeadura selecionadas foram baseadas no Zoneamento Agroclimático da cultura da soja, elaborado pela Coordenação Nacional do Zoneamento Agrícola. As produtividades estimadas foram comparados com as produtividades reais obtidas através de dados do IBGE. O modelo apresentou correlações significativas entre as produtividades reais e as estimadas,a nível estadual. Os coeficientes de determinação para os estados de Goiás, Mato Grosso, Paraná, Rio Grande do Sul a São Paulo foram respectivamente, 0,5831; 0,6933;0,9162; 0,8504; 0,6426
Abstract: Agriculture is the economic activity more affected by the climate. The meteorologicalphenomena like temperature, precipitation, relative humidity or wind speed have influence in the productivity and agricultural product quality, as well as in the productioncosts.One of the tools more used to quantify the effect caused for the meteorological phenomenain the agricultural productivity is the agrometeorologicalmodel. In the present work an agrometeorologicalmodel for estimate the productivity of the soybean was studied using a total of 66 cities in the states of Goiás, Mato Grosso, Paraná, Rio Grande do Sul and São Paulo. Productivity data of soybean was crossed with rainfall data of pluviometric stations observedbetweenthe years of 1994to the 2000. It was also used pedological maps for differentiation of the types of predominant soil in each city for estimating available water hold capacity of the soil. Historical data was used for estimasting the average of the potential evapotranspiration (ETP) for decendial hidric . balance and evapotranpiration reference (ETR). The selected times for seeding were based on the Agroclimatic Risc Zoning for soybean, elaborated for the National Coordination of the Agricultural Zoning. The calculated produtivities were compared with the data of produtivitiesused by IBGE. The model presented significant correlations between the real produtivities at the leveI of states. The coefficients of determination for the states of Goiás, Mato Grosso, Paraná, Rio Grande do Sul and São Paulo were respectively, 0,5831; 0,6933; 0,9162; 0,8504; 0,6426
Mestrado
Agua e Solo
Mestre em Engenharia Agrícola

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Tice, Meghan A. "A Spoonful of Salt Helps the Vegetables Go Down: Exploring the Processing of Health and Nutrition-related Claims in Advertising". Thesis, Virginia Tech, 2011. http://hdl.handle.net/10919/32671.

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In light of recent persuasive appeals which promote a food productâ s health or nutritional benefits in advertisements, this exploratory study investigates the ways in which individuals read and understand health and nutrition-related claims in advertising and make subsequent judgments about the product, brand, and purchase intentions. Using the Elaboration-Likelihood model of persuasion, this study looks at how motivational (e.g., health consciousness, need for cognition) and ability (nutrition knowledge) factors influence attitudes toward three food products following exposure to manipulated advertisements containing a nutrition-related claim. Although the results do not demonstrate much support for the predicted relationships, the findings nonetheless provide researchers useful information that may benefit future studies.
Master of Arts

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SILVA, Karla Alcione da. "Análise da eficiência de métodos de controle de Enchentes na atenuação de picos de cheias utilizando o modelo computacional SWMM Storm Water managemente model". Universidade Federal de Goiás, 2007. http://repositorio.bc.ufg.br/tede/handle/tde/645.

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This research presents an evaluation of the eficiency of four flood control measures applied to an urban basin in the city of Goiânia, State of Goiás, Brazil. Goiânia shows frequent flooding problems. The following factors have been identified as causes of the floodings: (1) significant number of impervious areas (2) lack of green areas, (3) insuficient capacity of the pipe network to convey the produced water volume. Small detention basins, infiltration trenches and the increase of permeable areas (30-50%) within parcels have been evaluated as flood control measures as well as the use of the Lago do Bosque dos Buritis as a detention basin. For this purpose, the Stormwater Management Model SWMM has been applied for evaluating 11 hypothetic management measures in the water basin. The later control measures were evaluated individually as combined. In determining the impervious area index of the studied area, field visits have been carried out, which showed high imperviousness. (86.16%). A synthetic rainfall time series, derived from the equation proposed by Costa e Brito (1999) with recurrence of 2 years, has been used in the simulations. Horton`s equation was applied to represent infiltration with parameters presented in Moura (2005). The scenario which combines the use of infiltration trenches and the increase of pervious areas to 50% has shown to be the best solution in reducing peak flow with 43% eficiency. On the other hand, the scenario using detention basins presented the smallest efficiency (3%).
O presente trabalho apresenta a avaliação da eficiência de quatro métodos de controle de enchentes em uma bacia urbana localizada na cidade de Goiânia, que apresenta graves problemas de inundação. Estes alagamentos devem-se a alguns fatores que foram levantados, tais como: muitas áreas impermeabilizadas, poucas áreas verdes e rede com dimensões pequenas e insuficientes para o escoamento de todo o volume produzido. Foram analisadas a implantação de microservatórios de detenção, trincheira de infiltração, o aumento da área permeável no interior do lotes (de 30% e 50%) e o uso dos lagos do Bosque dos Buritis como dispositivo de controle. Para tanto, procederam-se simulações no modelo computacional SWMM Storm Water Management Model em que foram avaliados 11 cenários hipotéticos na bacia, que consistiram na aplicação dos dispositivos de forma individual e em conjunto. Para a determinação do índice de impermeabilização da área estudada foi necessário realizar um levantamento em uma área amostra, o qual demonstrou uma média de 86.16% de impermeabilização em cada lote. A precipitação utilizada foi uma série sintética, determinada por meio da equação de chuva desenvolvida por Costa e Brito (1999) com tempo de recorrência adotado de 2 anos. Para representar a infiltração, optou-se por trabalhar com a equação de infiltração de Horton, segundo os parâmetros de Moura (2005). O cenário simulado com a implantação de trincheira de infiltração e o aumento da área permeável em 50% apresentou aproximadamente 43% de eficiência na redução da vazão de pico, indicando que essa poderia ser a melhor solução para o problema analisado, enquanto que o cenário com microreservatórios apresentou a menor eficiência, aproximadamente 3%.

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Azevedo, Lícia Maria Nunes de. "Calibração, validação e aplicação do modelo invest para a estimativa de benefícios aos serviços ecossistêmico na bacia do Ribeirão Pipiripau (DF/GO)". reponame:Repositório Institucional da UnB, 2017. http://repositorio.unb.br/handle/10482/31495.

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Dissertação (mestrado)—Universidade de Brasília, Faculdade de Tecnologia, Departamento de Engenharia Florestal, Programa de Pós-Graduação em Ciências Florestais, 2017.
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Os serviços ecossistêmicos têm recebido especial atenção por parte de gestores ambientais. Assim, é de fundamental importância entender quais são os benefícios da alteração do uso do solo a partir da adoção de técnicas para a restauração florestal como também da adoção de práticas de conservação do solo no comportamento e na capacidade de geração dos serviços ecossistêmicos. Para compreender a importância da adoção de práticas conservacionistas para a gestão dos recursos hídricos, este estudo teve como objetivo calibrar, validar e aplicar o modelo InVEST para estimar os benefícios aos serviços ecossistêmicos, em termos de redução do aporte de sedimentos e incremento no provimento de água na bacia hidrográfica do ribeirão Pipiripau. A bacia do Ribeirão Pipiripau está localizada no nordeste do Distrito Federal, na divisa com o município de Formosa/GO, ocupa uma área total de 23.527 hectares e faz parte do projeto Programa Produtor de Água (PdA) no Distrito Federal. Foram simulados a situação atual da bacia e 2 cenários de ações de passivo ambiental em 3 cenários climáticos. Na calibração e validação do modelo de exportação de sedimentos e do modelo de produção de água sazonal, os dados gerados apresentaram resultados que acompanham os dados hidrossedimentologicos da bacia. O aporte de sedimento médio na bacia foi de 1.555 t/ano e a vazão liquida foi 2,49 m³/s. Nos cenários futuros, as simulações geraram uma redução de até 44% do aporte de sedimento na bacia, uma redução de até 69 mm na produção superficial de água e um aumento de até 46 mm na produção de escoamento de base. Conclui-se que o uso dessa ferramenta pode auxiliar na predição de consequências hidrológicas a partir de mudanças de uso do solo, tais como as alterações promovidas pelo Programa Produtor de Água que visam reduzir o aporte de sedimentos e aumentar a infiltração de água no solo.
Ecosystem services have received special attention from environmental managers. Therefore, it is of fundamental importance to understand the benefits of altering land use through the techniques adoption for forest restoration as well as the adoption of soil conservation practices in the behavior and capacity to generate ecosystem services. In order to understand the importance of the adoption of conservation practices for the management of water resources, this study aimed to calibrate, validate and apply the InVEST model to estimate the benefits to ecosystem services in terms of reduction of sediment supply and increment in water supply in the watershed of the Pipiripau stream. The Pipiripau stream basin is located in the northeast of the Distrito Federal on the border with the municipality of Formosa / GO, occupies an area of 23,527 hectares and it is part of the Water Producer Program (PdA) in the Distrito Federal. The simulation was performed for current situation of the basin and for 2 scenarios of actions of environmental liabilities in 3 climatic scenarios. In the calibration and validation of the sediment export model and the seasonal water production model the data generated presented results that accompany the hydrosedimentological data of the basin. The mean sediment yield in the basin was 1,555 t/year and the net flow was 2.49 m³/s. In the future scenarios, the simulations generated a reduction of up to 44% in the sediment load in the basin, a reduction of up to 69 mm of quickflow and an increase of up to 46 mm of base flow. It is concluded that the use of this tool can help in the prediction of hydrological consequences from changes in land use, such as the changes promoted by the Water Producer Program, which aim to reduce the contribution of sediments and increase the infiltration of water in the soil.

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