Rozprawy doktorskie na temat „Glycoproteins”
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Jefferies, W. A. "Lymphocyte surface glycoproteins". Thesis, University of Oxford, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355757.
Pełny tekst źródłaClark, R. A. C. "Characterisation of neural glycoproteins". Thesis, University of Cambridge, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363826.
Pełny tekst źródłaPremdjee, B. "Semi-synthesis of glycoproteins". Thesis, University College London (University of London), 2014. http://discovery.ucl.ac.uk/1434897/.
Pełny tekst źródłaCrispin, Matthew D. M. "Manipulation and crystallisation of glycoproteins". Thesis, University of Oxford, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.426374.
Pełny tekst źródłaPriyanka, Pragya. "Chemoenzymatic synthesis of phosphorylated glycoproteins". Thesis, University of Canterbury. Chemistry, 2015. http://hdl.handle.net/10092/10578.
Pełny tekst źródłaDuffy, Iain. "Analysis of measles virus glycoproteins". Thesis, Queen's University Belfast, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.324842.
Pełny tekst źródłaKaye, Jane Frances. "Studies of human cytomegalovirus glycoproteins". Thesis, University of Cambridge, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.259731.
Pełny tekst źródłaBECKMANN, M. PATRICIA. "SYNTHESIS AND OLIGOSACCHARIDE PROCESSING OF NORMAL AND ALTERED IMMUNOGLOBULIN M DURING B-CELL DIFFERENTIATION (GLYCOPROTEIN, GLYCOPEPTIDE, MUTANT, CARBOHYDRATE, ASPARAGINE-LINKED)". Diss., The University of Arizona, 1985. http://hdl.handle.net/10150/187906.
Pełny tekst źródłaChan, Chun-yu. "Mass spectrometric analysis of selected glycoproteins". Thesis, Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B3147942X.
Pełny tekst źródłaPerry, J. Jefferson P. "Structural studies of cell surface glycoproteins". Thesis, University of Cambridge, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368608.
Pełny tekst źródłaEdwards, Cathryn M. "Mucus glycoproteins in the diverted colorectum". Thesis, University of Oxford, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.365830.
Pełny tekst źródłaSage, Karen Anne. "The synthesis of glycopeptides and glycoproteins". Thesis, University of Oxford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.360466.
Pełny tekst źródłaGupta, G. "Artificial lectins : biomimetic ligands for glycoproteins". Thesis, University of Cambridge, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.599789.
Pełny tekst źródłaJuhasz, Katalin. "Major glycoproteins of turkey rhinotracheitis virus". Thesis, University of Warwick, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283496.
Pełny tekst źródłaBristow, Richard G. W. "Antibody recognition of HIV-1 glycoproteins". Thesis, Open University, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315370.
Pełny tekst źródłaStephenson-Brown, Alexander James. "Synthetic sensors for saccharides and glycoproteins". Thesis, University of Birmingham, 2015. http://etheses.bham.ac.uk//id/eprint/5728/.
Pełny tekst źródłaWood, Sarah Louise. "Glycoproteins of the chromaffin granule membrane". Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/19427.
Pełny tekst źródłaDemers, Audrey Gertrude. "Structural studies of glycoproteins in solution". Case Western Reserve University School of Graduate Studies / OhioLINK, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=case1054759177.
Pełny tekst źródłaMacmillan, Derek. "The synthesis of novel homogeneous glycoproteins". Thesis, University of Edinburgh, 1999. http://webex.lib.ed.ac.uk/abstracts/macmil01.pdf.
Pełny tekst źródłaVasiliauskaite, Ieva. "Structural characterization of viral envelope glycoproteins". Thesis, Paris 6, 2014. http://www.theses.fr/2014PA066507/document.
Pełny tekst źródłaViral glycoproteins are responsible for the two major steps in entry into host cells by enveloped viruses: 1) attachment to cellular receptor/s and 2) fusion of the viral and cellular membranes. My thesis concentrated first on the structural analysis of the major envelope glycoprotein E2 of two hepaciviruses: GB virus B (GBV-B) and hepatitis C virus (HCV). Crystallization of the GBV-B E2 ectodomain remained unsuccessful, but the characterization of truncated versions of E2 suggested an important role of its C-terminal moiety in receptor binding. In parallel, I co-crystallized a synthetic peptide mimicking HCV E2 with an antibody fragment directed against the major receptor-binding loop of E2 that is targeted by broadly neutralizing antibodies. The structure unexpectedly revealed an α-helical peptide conformation, which is in stark contrast to the extended conformation of this region observed in the structure of an E2 core fragment. Together with further biochemical evidence this suggests an unanticipated structural flexibility within this region in the context of the soluble E2 ectodomain. Secondly, I focused on the structural analysis of the baculovirus glycoprotein F. I determined the crystal structure of the post-fusion trimer of a trypsin-truncated F fragment. This structure confirmed previous predictions that baculovirus F protein adopts a class I fusion protein fold and is homologous to the paramyxovirus F protein. Baculovirus F is therefore the first class I fusion protein encoded by a DNA virus. My results support the hypothesis that F proteins may have a common ancestor and imply interesting evolutionary links between DNA and RNA viruses and their hosts
Vasiliauskaite, Ieva. "Structural characterization of viral envelope glycoproteins". Electronic Thesis or Diss., Paris 6, 2014. https://accesdistant.sorbonne-universite.fr/login?url=https://theses-intra.sorbonne-universite.fr/2014PA066507.pdf.
Pełny tekst źródłaViral glycoproteins are responsible for the two major steps in entry into host cells by enveloped viruses: 1) attachment to cellular receptor/s and 2) fusion of the viral and cellular membranes. My thesis concentrated first on the structural analysis of the major envelope glycoprotein E2 of two hepaciviruses: GB virus B (GBV-B) and hepatitis C virus (HCV). Crystallization of the GBV-B E2 ectodomain remained unsuccessful, but the characterization of truncated versions of E2 suggested an important role of its C-terminal moiety in receptor binding. In parallel, I co-crystallized a synthetic peptide mimicking HCV E2 with an antibody fragment directed against the major receptor-binding loop of E2 that is targeted by broadly neutralizing antibodies. The structure unexpectedly revealed an α-helical peptide conformation, which is in stark contrast to the extended conformation of this region observed in the structure of an E2 core fragment. Together with further biochemical evidence this suggests an unanticipated structural flexibility within this region in the context of the soluble E2 ectodomain. Secondly, I focused on the structural analysis of the baculovirus glycoprotein F. I determined the crystal structure of the post-fusion trimer of a trypsin-truncated F fragment. This structure confirmed previous predictions that baculovirus F protein adopts a class I fusion protein fold and is homologous to the paramyxovirus F protein. Baculovirus F is therefore the first class I fusion protein encoded by a DNA virus. My results support the hypothesis that F proteins may have a common ancestor and imply interesting evolutionary links between DNA and RNA viruses and their hosts
Ritchie, Gayle E. "The glycosylation of viral envelope glycoproteins and the effect of glycosidase inhibitors on virus replication and glycoprotein properties". Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.442908.
Pełny tekst źródłaFyrner, Timmy. "Synthesis of Structures Related to Antifreeze Glycoproteins". Thesis, Linköping University, The Department of Physics, Chemistry and Biology, 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-11941.
Pełny tekst źródłaIn this thesis, synthesis of structures related to antifreeze glycoproteins (AFGPs) are presented. Synthetic routes to a protected carbohydrate derivative, 2,3,4,6-tetra-O-benzyl-β-galactopyranosyl-(1→3)-2-deoxy-2-azido-4,6-di-O-benzyl-β-D-thio-1-galactopyranoside, and a tBu-Ala-Thr-Ala-Fmoc tripeptide, are described. These compounds are meant to be used in the assembly of AFGPs and analogues thereof. A Gal-GlcN disaccharide was synthesized via glycosylation between the donor, bromo-2-O-benzoyl-3,4,6-tri-O-benzyl-α-Dgalactopyranoside, and acceptor, ethyl 4,6-O-benzylidene-2-deoxy-2-N-phthalimido-β-D-1-thio-glucopyranoside, using silver triflate activation. Subsequent epimerization to a Gal-GalN disaccharide was achieved using Moffatt oxidation followed by L-selectride® reduction. The tripeptide was synthesized in a short and convenient manner using solid phase peptide synthesis with immobilized Fmoc-Ala on Wang® resins as starting point.
Kramer, Holger. "Synthesis of Glycoproteins and C-linked Glycopeptides". Thesis, University of Oxford, 2006. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487272.
Pełny tekst źródłaSpäte, Anne-Katrin [Verfasser]. "Metabolic Engineering of Glycoproteins / Anne-Katrin Späte". Konstanz : Bibliothek der Universität Konstanz, 2016. http://d-nb.info/1114893870/34.
Pełny tekst źródłaHemming, Richard John. "Radioautographical and biochemical studies on nucleoplasmic glycoproteins". Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=41298.
Pełny tekst źródłaKrishna, Sudhir. "T cell recognition of HSV-1 glycoproteins". Thesis, University of Cambridge, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317944.
Pełny tekst źródłaSmyth, Edward. "Raman optical activity of proteins and glycoproteins". Thesis, University of Glasgow, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.312130.
Pełny tekst źródłaField, Mark C. "Structural studies on oligosaccharides from mammalian glycoproteins". Thesis, University of Oxford, 1989. http://ora.ox.ac.uk/objects/uuid:163fb9d7-43b7-4347-ab81-ce3cb87cb3f9.
Pełny tekst źródłaSnowden, B. W. "Structural and functional studies of herpesvirus glycoproteins". Thesis, University of Leeds, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.355709.
Pełny tekst źródłaFielding, Adel Kay. "Targeting fusogenic retroviral glycoproteins by ligand display". Thesis, University of London, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322305.
Pełny tekst źródłaSpring, F. A. "Surface glycoproteins of normal and leukaemic leucocytes". Thesis, University of Bristol, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.370674.
Pełny tekst źródłaZeng, Chenhui. "Structure determination of glycoproteins by mass spectrometry". Thesis, Massachusetts Institute of Technology, 1996. http://hdl.handle.net/1721.1/40167.
Pełny tekst źródłaGraham, Richard Peter. "Purification of glycoproteins from herpes simplex virus". Master's thesis, University of Cape Town, 1985. http://hdl.handle.net/11427/25694.
Pełny tekst źródłaSoby, Lynn Margaret. "Structure and viscoelasticity of proteoglycans and glycoproteins". Case Western Reserve University School of Graduate Studies / OhioLINK, 1990. http://rave.ohiolink.edu/etdc/view?acc_num=case1059058747.
Pełny tekst źródłaWang, Siyao. "Total Synthesis of Homogeneous Glycopeptides and Glycoproteins". Thesis, The University of Sydney, 2018. http://hdl.handle.net/2123/18329.
Pełny tekst źródłaD'Souza, Yvonne. "Glycoproteins of drusen and drusen-like lesions". Thesis, University of Manchester, 2008. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.489005.
Pełny tekst źródłaBill, Roslyn M. "A study towards the chemical glycosylation of recombinant human erythroprotein". Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.240573.
Pełny tekst źródłaByth, Katharine Fiona. "The targeted disruption of the CD45 gene in transgenic mice". Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.336538.
Pełny tekst źródłaTomlinson, Michael Graham. "Structure and function of the leukocyte and surface antigens CD53 and CD37". Thesis, University of Oxford, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308502.
Pełny tekst źródłaLam, Ka-wai, i 林嘉維. "Glycodelin-A as a modulator of trophoblast invasion". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2010. http://hub.hku.hk/bib/B45598964.
Pełny tekst źródłaKemp, Pauline Anne. "The glycosylation of human alpha-1-antitrypsin expressed in transgenic mouse milk". Thesis, University of Kent, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298167.
Pełny tekst źródłaRunswick, Sarah Kay. "Expression of laminin in the developing central nervous system of the chick embryo". Thesis, University of Liverpool, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295823.
Pełny tekst źródłaHaston, Jennifer Louise. "The inhibition of type II collagen fibril formation in rheumatoid arthritis". Thesis, University of Strathclyde, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248329.
Pełny tekst źródłaMalloy, Andrew Robert. "Atomic force microscopy studies of glycophorin A-BRAC 30 antigen-antibody interactions". Thesis, University of Bristol, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.247173.
Pełny tekst źródłaMolesworth, Sara J. I. M. "Expression and assembly of the Epstein-Barr virus (EBV) gp85, gp25 and gp42 fusion complex in the baculovirus system". Thesis, University of Bristol, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361142.
Pełny tekst źródłaDee, Valerie Murielle. "Multiple forms of human complement factor H". Thesis, University of Oxford, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.670272.
Pełny tekst źródłaCheng, Chi-keung. "Structural organization of the mouse testin gene and characterization of its promoter sequence". Hong Kong : University of Hong Kong, 2000. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22424763.
Pełny tekst źródłaPerrine, Cynthia L. "Profiling Glycosyltransferase Peptide Substrate Specificities: Studies on ppGalNAc T1, T2, T10, and T-synthase That Initiate Mucin-Type O-Glycosylation". Cleveland, Ohio : Case Western Reserve University, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=case1253046997.
Pełny tekst źródłaTitle from PDF (viewed on 2009-12-30) Department of Chemistry Includes abstract Includes bibliographical references and appendices Available online via the OhioLINK ETD Center
Sabry, Zaki Tlep Sahar. "Identification of the molecular origins of disease in a cohort of patients with suspected congenital disorders of glycosylation (CDG)". Thesis, Paris 6, 2016. http://www.theses.fr/2016PA066715/document.
Pełny tekst źródłaBackground: Congenital disorders of glycosylation (CDGs) are rare inherited diseases caused by mutations in genes required for glycoconjugate biosynthesis. CDG clinical presentations range from monosystemic to multiorgan failure. Often these diseases are diagnosed biochemically by the presence of hypoglycosylated serum proteins. Molecular diagnosis of CDG is crucial for both antenatal diagnostics and development of treatment strategies. Aims: To determine the molecular origins of disease in suspected CDG patients. Two cases were chosen for more extended biochemical explorations in order to investigate the consequences of the mutations and possible treatment strategies. Subjects/Methods: Biochemical explorations of skin biopsy fibroblasts from a cohort of patients presenting with signs suggestive of CDG, and serum protein hypoglycosylation. Results and conclusions: In the first study, a patient presented with multisystemic disease suggesting CDG. Fibroblasts revealed both truncated dolichol-linked oligosaccharides and polymannose-type N-glycans. Mutations in the dehydrodolichol diphosphate synthase (DHDDS) gene were found as well as low DHDDS activity and dolichol phosphate levels. As previous cases of DHDDS-CDG present with retinitis pigmentosa only, we describe the first case of a CDG syndrome associated with mutations in DHDDS. In the second study, two siblings presented with thrombocytopenia and CNS signs. A biallelic mutation in the CMP-sialic acid transporter gene (SLC35A1) was associated with hyposialylated serum glycoproteins. Altered glycosphingolipid profiles were seen and sialic acid supplementation of patient cells increased the appearance of gangliosides