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Rozprawy doktorskie na temat „Germ cells”

Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 25 lipca 2025

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1

Hajkova, Petra. "Epigenetic reprogramming in mouse germ cells." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=970526938.

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2

Hajkova, Petra. "Epigenetic reprogramming in mouse germ cells." Doctoral thesis, Humboldt-Universität zu Berlin, Mathematisch-Naturwissenschaftliche Fakultät I, 2004. http://dx.doi.org/10.18452/15020.

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Bei Säugerkeimzellen, Zygoten und Embryos in frühen Stadien kommt der epigenetischen Neuprogammierung eine außergewöhnlich wichtige Rolle in der Regulation der Genomfunktionen in entscheidenden Entwicklungsstadien zu. Die epigenetische Neuprogrammierung in Keimzellen löscht zuerst die Imprinting-Markierungen und Epi-Mutationen und stellt dann geschlechtsspezifische Markierungen (genomische Prägung) wieder her. Die vorliegende Arbeit bezieht sich auf das Löschen epigenetischer Modifikationen in primordialen Mauskeimzellen (primordial germ cells (PGCs)) zwischen dem 10.5 bis 13.5 Tag nach der

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3

Ono, Tetsuo. "Novel preservation method of germ cells and somatic cells." Kyoto University, 2010. http://hdl.handle.net/2433/120542.

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4

Camacho, Moll Maria Elena. "Germ cell neoplasia in situ (GCNIS) and the pathogenesis of testicular germ cell cancer." Thesis, University of Edinburgh, 2017. http://hdl.handle.net/1842/28807.

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Testicular germ cell cancer (TGCC) has been increasing in incidence over recent decades, and is currently the most common malignancy amongst young men resulting in significant morbidity. These tumours are believed to arise from premalignant germ cell neoplasia in situ (GCNIS) cells, which originate from the aberrant germ cell differentiation from gonocyte to spermatogonia during fetal/early postnatal life. GCNIS cells remain dormant in the testis until puberty when they are activated to become tumours. Therefore, GCNIS cells remain in a pre-invasive stage during early childhood and early adult

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5

Cowan, Gillian. "Fetal germ cell differentiation and the impact of the somatic cells." Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4164.

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Specification of a germ cell lineage and appropriate maturation are essential for the transfer of genetic information from one generation to the next. Germ cells form from pluripotent precursor cells that migrate into the gonadal ridge and undergo commitment to either the female or male lineage. In the fetal ovary, germ cells enter meiotic prophase I, then arrest at the diplotene stage; in the testis germ cells do not begin meiosis until puberty. Abnormal differentiation of germ cells can result in malignant transformation. Somatic cells play a key role in modulating the developmental fate of

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6

Al-Thani, Rawda. "Primordial germ cells of the chick embryo." Thesis, University of Reading, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315524.

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7

Li, Ying. "Transgenic birds from transformed primordial germ cells." Thesis, University of Reading, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.385118.

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8

Yoon, Christina Migyung 1970. "Idenficiation of the zebrafish primordial germ cells." Thesis, Massachusetts Institute of Technology, 1997. http://hdl.handle.net/1721.1/43551.

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9

Somers, Christopher Michael Quinn James S. "Germline mutations at expanded simple tandem repeat DNA loci in sentinel mice /." *McMaster only, 2004.

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10

Leitch, Harry Gordon. "Pluripotency and the germline." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610336.

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11

Grabole, Nils. "Functional analysis of Prdm14 in primordial germ cells and stem cells." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608092.

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12

Mruk, Dolores Dorothy. "A study on the dynamics of sertoli-germ cell interactions : new perspectives on male fertility control /." Thesis, Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B22079002.

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13

Okumura, Leah M. "Germ cell nuclear factor is not required for the down-regulation of pluripotency markers in fetal ovarian germ cells." Thesis, Massachusetts Institute of Technology, 2012. http://hdl.handle.net/1721.1/77781.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Biology, 2012.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>In mouse, germ cells retain expression of the pluripotency markers Oct4 and Nanog longer than any other cells in the body. While somatic cells repress these markers during gastrulation, female germ cells continue to express them until around the time of meiotic initiation. It is not yet clear why pluripotency markers are downregulated with this particular timing, nor is it understood what factors are involved in their repression. I

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14

Wang, Qiufan Claire, and 王秋帆. "Mechanisms of junctional restructuring at the sertoli-sertoli and sertoli-germ cell interfaces during spermatogenesis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40887686.

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15

Wang, Qiufan Claire. "Mechanisms of junctional restructuring at the sertoli-sertoli and sertoli-germ cell interfaces during spermatogenesis." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40887686.

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16

Wigmore, Kip. "The primordial germ cells of the goat fetus." Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp01/MQ43237.pdf.

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17

Seisenberger, Stefanie. "Reprogramming the epigenome of mouse primordial germ cells." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610019.

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18

Vick, Lorraine Mary. "Genetic manipulation of fowl via primordial germ cells." Thesis, University of Reading, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.317960.

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19

Matias, Neuza. "Regulation of Abscission in Female Drosophila Germ Cells." Thesis, Paris 11, 2015. http://www.theses.fr/2015PA112211/document.

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En fin de cytocinèse, le fin pont cytoplasmique qui relie les deux cellules filles est clivé au niveau d’une structure dense en microtubules, le midbody, et permet ainsi la séparation physique de leurs deux cytoplasmes. Les mécanismes cellulaires et moléculaires de ce processus, appelé abscission, sont très étudiés dans des modèles de cellules en culture. Cependant, ils restent encore mal connus dans le contexte d’un organisme en développement. L’ovogenèse de drosophile est un modèle de choix pour l’étude de la régulation développementale de l’abscission. En effet, des cellules à abscission co

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20

Pogool, Satian. "Factors controlling migration of avian primordial germ cells." Thesis, University of Manchester, 2002. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531435.

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Avian embryos have played an important role in the study of vertebrate development but further understanding of their development may also benefit the commercial poultry industry. Manipulation and use of primordial germ cells (PGCs) as a vehicle for constructed genotypes will be increasingly important for future improvement of commercial poultry including the turkey. However, the manipulation and use of PGCs will depend on a basic understanding of PGC migration. PGCs are known to migrate considerable distances before colonising the gonad. Previous work in the chick and quail have suggested tha

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21

Mifsud, William. "Studies on the ontogeny of the mammalian germ line." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609789.

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22

Hamaguchi, Satoshi. "Sex differentiation of germ cells and their supporting cells in Oryzias latipes." Laboratory of Freshwater Fish Stocks, Nagoya University, 1992. http://hdl.handle.net/2237/13766.

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23

Sneddon, Sharon F. "Oestrogen regulation of gene expression in male germ cells and Sertoli cells." Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/29373.

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The aims of this study were to investigate the role of steroid hormones, in particular oestrogens, in murine spermatogenesis. A major focus of these investigations was the role played by ERβ in the modulation of germ cell and somatic cell function. Studies were conducted both using a transformed murine Sertoli cell line (SK11), which has maintained a differentiated Sertoli cell phenotype and spermatogonial stem cells, which were successfully isolated and characterised. ERβ mRNA and protein were shown to be expressed in the SK11 cells both in the undifferentiated and differentiated states. Tran

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24

Tee, Wee Wei. "Functional analysis of PRMT5 in mouse pluripotent stem cells and germ cells." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608638.

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25

STALLOCK, JAMES PATRICK. "THE ROLE OF BAX IN APOPTOSIS OF ECTOPIC PRIMORDIAL GERM CELLS IN THE MOUSE." University of Cincinnati / OhioLINK, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1046891667.

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26

Xia, Weiliang, and 夏偉梁. "Role of cytokines in junction restructuring and germ cell migration inmammalian testes." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37101134.

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27

Petyim, Somsim. "Gene regulation during development of human primordial germ cells." Thesis, University of Nottingham, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.665476.

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A critical event during embryonic development is the segregation of the germ line from the soma. The germ line founders, or primordial germ cells (PO C), are the precursors of the gametes, which enable the transmission of the genetic material to future generations. In rodents, the PGC precursors are segregated from somatic lineages before the start of gastrulation. In several model organisms segregation of the germ line is accomplished by maternally inherited transcriptional repressors contained in the egg's germ plasm. In mammals, PGC specification is regulated by epigenesis, a mechanism by w

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28

Adhikari, Deepak. "Signaling pathways in the development of female germ cells." Doctoral thesis, Umeå universitet, Institutionen för medicinsk kemi och biofysik, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-88309.

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Primordial follicles are the first small follicles to appear in the mammalian ovary. Women are born with a fixed number of primordial follicles in the ovaries. Once formed, the pool of primordial follicles serves as a source of developing follicles and oocytes. The first aim of this thesis was to investigate the functional role of the intra-oocyte signaling pathways, especially the phosphatidylinositol-3 kinase (PI3K) and mammalian target of rapamycin complex 1 (mTORC1) pathways in the regulation of primordial follicle activation and survival. We found that a primordial follicle remains dorman

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29

Intarapat, S. "Isolation and characterisation of chick embryonic primordial germ cells." Thesis, University College London (University of London), 2012. http://discovery.ucl.ac.uk/1344049/.

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Embryonic stem cells (cESCs) can be isolated from chick embryos, with the ability to contribute to all somatic lineages in chimaeras, but not to the germ line. However, lines of chicken embryonic germ cells (cEGCs), which are able to contribute to the germ line, can be established from chicken primordial germ cells (cPGCs). However very little is known about these cells, or about the changes that accompany the establishment of gonadal cells as self-renewing cell lines. This thesis presents a detailed study of the properties of cPGCs and the parent tissue from which they are derived. Gene expre

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30

Xia, Weiliang. "Role of cytokines in junction restructuring and germ cell migration in mammalian testes." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B37101134.

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31

Jiang, Shan. "Establishing genomic imprinting by cell differentiation a model system using embryonic germ cells /." Available to US Hopkins community, 2000. http://wwwlib.umi.com/dissertations/dlnow/3099377.

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32

Lokman, Muhammad. "Development of post-meiotic germ cells from human embryonic stem cells in vitro." Thesis, University of Sheffield, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531176.

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33

Wong, Ching-hang. "Cell-cell interactions and cell junction dynamics in the mammalian testis." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31993084.

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34

Kasai, Shinya. "Haploinsufficiency of Bcl-x leads to male specific defects in fetal germ cells : differential regulation of germ cell apoptosis between the sexes." Kyoto University, 2004. http://hdl.handle.net/2433/148262.

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35

Ewen-Campen, Benjamin Scott. "An evolutionary perspective on germ cell specification genes in insects." Thesis, Harvard University, 2014. http://dissertations.umi.com/gsas.harvard:11549.

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This dissertation investigates the embryonic specification of a specific group of cells: the germ cells. Germ cells, which give rise to sperm and egg, are the only cells in sexually-reproducing animals that directly contribute hereditary information to the next generation. Germ cells are therefore a universal cell type across animals, and represent a profound novelty that likely arose near the base of the animal phylogeny. Yet despite their conserved, essential function in all animals, there is surprising diversity in the mechanisms that specify these cells during embryonic development. In thi

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36

McCormick, Rachel Jacqueline. "Investigations into Xpat, a novel gene expressed in the germ plasm and primordial germ cells of Xenopus laevis." Thesis, University of Warwick, 2001. http://wrap.warwick.ac.uk/3093/.

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To determine the expression pattern of XPAT (Xenopus primordial germ cell associated transcript) protein in Xenopus oocytes, XPAT-GFP fusion proteins were generated. When XPAT was amino-terminally tagged with GFP it became localised to the nuclei of stage VI Xenopus oocytes. However, when carboxy-terminally tagged with GFP, XPAT also translocated to the vegetal pole of stage VI oocytes. XPAT-GFP formed particles (1 to 2.5mm in diameter) which aggregated into large (10 to 50mm) granular structures at the vegetal pole. These particles looked exactly like those seen after in situ hybridisation to

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37

Angeles, Vanessa Therese. "Characterization of NANOS expression and function in human germ cells." Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3390030.

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38

Severino, Jacqueline 1990. "X chromosome status : a gatekeeper of germ cells meiotic entry." Doctoral thesis, TDX (Tesis Doctorals en Xarxa), 2021. http://hdl.handle.net/10803/671536.

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X chromosome reactivation in female mouse germ cells is essential for the transmission of one active X chromosome to the progeny. However, despite its key role in development, the mechanistic details and kinetics still remain elusive, as previous studies were restricted by a scarcity of cells in vivo and a lack of adequate in vitro systems. Here, I present the characterization of X-chromosome dynamics during germ cell formation, which was possible thanks to the development of a tailor-made in vitro system which allows the accurate profiling of X-chromosome activity. We recapitulate X-inac

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39

Molaro, Antoine. "Inheritance and evolution of epigenetic reprogramming in Mammalian germ cells." Phd thesis, Université Pierre et Marie Curie - Paris VI, 2012. http://tel.archives-ouvertes.fr/tel-00833274.

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During mammalian post-implantation development, germ cells are induced from the somatic tissues of the embryo. Following their induction, primordial germ cells undergo a genome-wide erasure and de novo re-establishment of DNA methylation marks. This epigenetic reprogramming re-instates pluripotency and allows parental imprints to be deposited. In the male germ line, a unique RNAi pathway involving PIWI proteins and their associated small RNAs (piRNAs) is necessary for proper de novo methylation. PIWI mutant mice are infertile and display methylation defects over transposon sequences. Using a t

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40

Hurtado, Gonzalez Pablo Ignacio. "The consequences of fetal exposure to analgesics for germ cells." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/29631.

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Despite the general advice of avoiding medication during pregnancy, the majority of pregnant woman use one or more ‘over the counter’ analgesics. During the last few years there has been growing evidence that analgesic exposure, such as paracetamol, ibuprofen or indomethacin, during pregnancy can have detrimental effects on rodent and human fetal gonads. The majority of previous studies have focused in alterations in testosterone production and male reproductive disorders. However, few studies have analysed the effect of these analgesics on fetal germ cells and possible consequences on fertili

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41

LOLICATO, FRANCESCA. "Molecular mechanisms involved in spermatogonial germ cells proliferation and differentiation." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2008. http://hdl.handle.net/2108/514.

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Lo scopo del seguente lavoro, è comprendere alcuni dei meccanismi molecolari coinvolti nella regolazione della proliferazione e del differenziamento degli spermatogoni nel testicolo prepuberale di topo. Lo studio ha riguardato la caratterizzazione della RNA-binding-protein Nanos 3 e il suo coinvolgimento nella progressione del ciclo cellulare degli spermatogoni e l’analisi dell’espressione genica negli spermatogoni in seguito a trattamento con i fattori Kit ligand e acido retinico, coinvolti rispettivamente nella proliferazione e nel differenziamento in questo tipo cellulare. Nel topo sono s

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42

El, Sharnouby Sherif Maher. "Methodology for genome-wide epigenetic profiling of the Drosophila male germline." Thesis, University of Cambridge, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.609941.

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43

Cassidy, Liam David. "The evolution of cancer in germline BRCA2 mutation carriers." Thesis, University of Cambridge, 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648683.

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Chung, Shui-wah. "Cell-cell interactions in the rat testis : biology and future perspectives /." Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B2056692X.

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45

Roewer, Jesse F. "CONSEQUENCE OF PREMATURE AND CHRONIC LUTEINIZING HORMONE RECEPTOR ACTIVATION ON TESTICULAR SPERMATOGENIC CELL DEVELOPMENT." OpenSIUC, 2010. https://opensiuc.lib.siu.edu/theses/253.

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Luteinizing hormone (LH), one of the two gonadotropin hormones released from the anterior pituitary gland, binds to its receptor (LHR) in the gonads to stimulate steroid hormone production, in addition to ovulation and gametogenesis. Mutations of the receptors amino acid sequence have the ability to either constitutively activate or inactivate it. All activating mutations result in male-limited precocious puberty. Males with this condition undergo puberty around 4 years of age, and have a premature elevation in testosterone levels and premature skeletal development. In order to understand how

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46

Wong, Ching-hang, and 黃政珩. "Cell-cell interactions and cell junction dynamics in the mammalian testis." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31993084.

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47

Yamaguchi, Shinpei. "Conditional Knockdown of Nanog Induces Apoptotic Cell Death in Mouse Migrating Primordial Germ Cells." Kyoto University, 2010. http://hdl.handle.net/2433/97931.

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48

Murase, Yusuke. "Long-term expansion with germline potential of human primordial germ cell-like cells in vitro." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/261607.

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京都大学<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第22880号<br>医博第4674号<br>新制||医||1047(附属図書館)<br>京都大学大学院医学研究科医学専攻<br>(主査)教授篠原隆司, 教授近藤玄, 教授万代昌紀<br>学位規則第4条第1項該当<br>Doctor of Medical Science<br>Kyoto University<br>DFAM

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49

Nakaki, Fumio. "Induction of mouse germ-cell fate by transcription factors in vitro." Kyoto University, 2014. http://hdl.handle.net/2433/188684.

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50

Yamada, Yukiko. "Deciphering molecular mechanisms that regulate programmed cell death of primordial germ cells in Drosophila melanogaster." [Ames, Iowa : Iowa State University], 2007. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3337369.

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