Rozprawy doktorskie na temat „Genioglossus”
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Moore, Wayne Allen Jr. "Acute and Chronic Effects of Artificial Rearing on Rat Genioglossus Muscle". VCU Scholars Compass, 2005. http://scholarscompass.vcu.edu/etd/885.
Pełny tekst źródłaLaCross, Amy, Peter J. Watson i E. Fiona Bailey. "Association between Laryngeal Airway Aperture and the Discharge Rates of Genioglossus Motor Units". FRONTIERS MEDIA SA, 2017. http://hdl.handle.net/10150/622742.
Pełny tekst źródłaSouza, Jaqueline Freitas de. "Relação entre a força de língua e a posição do hioide em crianças com SAOS". Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17151/tde-25052018-135302/.
Pełny tekst źródłaObjective: The purpose of this study is to assess the relation between Force of the Tongue and measures of hyoid\'s positioning in children diagnosed with OSAS. Casuistry and Method: Were selected children between 07 and 12 years, from both genders, with snoring history, nocturnal apnea and chronic mouth breathing. All the children had OSAS confirmed by the sympton\'s presence and by the polysomnography and were divided into two groups: preoperative and postoperative (pacients that had OSAS diagnosed before the adenotonsillectomy,and were revaluated 12 months after. Both groups were submitted to maximum isometric tongue force, applied in the tip and in the back of the tongue, through the dynamometer and through the lateral radiography was performed a craniofacial evaluation and hyoid positioning. Results: In preoperative patients on linear regression the cephalometric measure D. vert. H presented strong and significant (p= 0,0083) negative relation with the tip of the tongue force. Whereas the back of the tongue before the surgery was not significant, for none of the variables. In postoperative patients the maximum isometric tongue force from the back and from the tip were significantly (p<0,0330 e p<0,0098 respectively) related to the cephalometric measure C3-H. The comparison between the cephalometric measures between the preoperative and postoperative groups and between the residual sub group and the healed ones, did not have difference in the hyoid\'s height (HYS, HYMP, D Vert.H) and on the hyoid\'s anteroposterior relation (D Horiz.H, C3-H). In regards to the maximum isometric tongue force from the extrinsic tongue musculature when compared to the average and standard deviation in patients pre and post surgery, it was noticed that there was difference for the tongue force measures (p= 0,0016 for the back and p=0,0041 for the tip) between them. There was no difference between the sub groups residual and healed. Conclusion: In the present study we can conclude that there is relation between the force of the lingual muscle and hyoid bone\'s position in children with OSAS. In other words, an increase on the pharynx dilator muscles\' strength can influence the hyoid\'s height in children with OSAS.
Laine, Christopher. "Decoding the Language of Hypoglossal Motor Control". Diss., The University of Arizona, 2011. http://hdl.handle.net/10150/203440.
Pełny tekst źródłaSilva, Junior Djalma Carmo Da. "Eficácia do avanço do músculo genioglosso comparado ao avanço maxilo-mandibular no tratamento da síndrome da apneia e hipopneia obstrutiva do sono : uma revisão sistemática com metanálise". Pós-Graduação em Ciências Aplicadas à Saúde, 2016. http://ri.ufs.br/jspui/handle/riufs/7210.
Pełny tekst źródłaA Síndrome da Apneia e Hipopneia Obstrutiva do Sono (SAHOS) caracteriza-se por repetidos episódios de interrupção completa ou parcial do fluxo de ar inspirado durante o sono em função da obstrução das vias aéreas superiores. Os critérios para a indicação de tratamento cirúrgico da SAHOS, bem como as evidências sobre a eficácia e segurança das técnicas cirúrgicas que impactam as vias aéreas superiores ainda merecem exploração científica adicional.Objetivo: Avaliar, por meio de uma revisão sistemática, a eficácia do avanço do músculo genioglosso (AMG) comparado ao avanço maxilo-mandibular (AMM) no tratamento de pacientes com SAHOS.Método:uma busca eletrônica sistemática foi realizada nas bases de dados LILACS, PubMed e SciELO com o intuito de identificar estudos com pacientes submetidos a cirurgia de avanço maxilo-mandibular e avanço do musculo genioglosso para o tratamento da SAHOS. A metodologia seguiu as diretrizes do PRISMA statement.Os artigos elegíveis foram avaliados subjetivamente quanto à qualidade metodológica com baseem um dos questionários do Critical Appraisal Skills Programme(CASP).Uma meta-análise dos artigos incluídos foi realizada com o auxílio do software RevMan.Resultados:A busca sistemática da literatura resultou em889 registros, dos quais 41 artigos foram examinados quanto a seu conteúdo. Depois da análise dos textos completos, seis estudos foram incluídos nesta revisão, permitindo inferências sobre a eficácia dos procedimentos cirúrgicos em questão.Conclusão:O avanço do músculo genioglosso demonstrou eficácia inferior à do avanço do músculo genioglosso, o que foi evidenciado por meio do índice de apneia hipopneia registrados através de polissonografias.Os resultados da meta-análise mostram que o AMM apresenta eficácia superior àquela doAMG no contexto do tratamento cirúrgico da SAHOS.
Lagarto, SE
Saboisky, Julian Peter Clinical School Prince of Wales Hospital Faculty of Medicine UNSW. "Neural drive to human respiratory muscles". Publisher:University of New South Wales. Clinical School - Prince of Wales Hospital, 2008. http://handle.unsw.edu.au/1959.4/42792.
Pełny tekst źródłaCurado, Thomaz Antonio Fleury. "O efeito da modulação quimiogenética de neurônios motores do hipoglosso sobre a atividade do músculo genioglosso". Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/5/5143/tde-13062017-162234/.
Pełny tekst źródłaIntroduction: Sleep Apnea is a prevalent condition and strongly correlates with the major causes of morbidity and mortality in Western Society. The loss of motor input from deeper sleep stages is associated with pharyngeal collapsibility and the pathogenesis of obstructive sleep apnea (OSA). The tongue plays a major role in the pathogenesis of upper airway (UA) obstruction during sleep. There is no pharmacotherapy for OSA. New molecular techniques allow to control neuronal function by inserting a genetically modified membrane receptor termed the Designer Receptor Exclusively Activated by Designer Drugs [DREADDs] which can be activated by a highly specific and otherwise pharmacologically inert drug clozapine-N-oxide (CNO) Objectives: 1) To genetically modify the hypoglossal nucleus motor neurons using DREADDs, which allows to regulate their activity; 2) To analyze the genioglossal activity upon administration of CNO; 3) to develop novel approaches to targeting tongue protruders and retractors by retrograde tracers, cholera toxin subunit B (CTB-AF) and pseudorabies virus (PRV) 267 injection carrying a reporter gene into the effector muscles. Methods: Mutated muscarinic receptors in an adenoviral associated vector (AAV) were delivered to the hypoglossal nucleus via stereotactically bilateral injection. Four weeks after adenoviral delivery (expression period), responses in genioglossal electromyography (EMGGG) activity to intraperitoneal administration of CNO ligand vs. Saline (control) were compared in mice. In a second group, control-virus was infused and genioglossus muscle EMGGG was compared before and after CNO infusion. For neuronal tracing CTB-AF was injected into the protrusor and retractor muscles of the tongue and for Cre induction PRV-267 virus was injected in the genioglossus muscle. Expression of these substances in the hypoglossal nucleus were evaluated by fluorescence histology. Results: Of eighteen DREADDs injected mice, sixteen were transfected with AAV vector. After CNO administration EMGGG activity increased in mice where the hypoglossal motor nucleus was correctly targeted. In contrast, genioglossal activity was not augmented following saline administration. In three mice where transfection surpassed the nucleus limits, breathing arrhythmia was observed following ligand infusion. All animals infused with control virus were adequately transfected but did not present electromyographic change following CNO infusion. The motor neurons of the rectractor and protrusor musculature of the tongue were well differentiated in the hypoglossal nucleus. Intranuclear expression of Cre recombinase enzyme was identified in the hypoglossal nucleus. Conclusion: Utilizing chemogenetic methods to activate motor neuron groups in selected brain areas show promise to UA neuromotor control, and suggest that transgenic therapy may be effective in treating OSA and a wide range of pathologies that result in disturbances of UA neural control. By manipulating the effector muscle fibers of the tongue, it was possible to identify its respective motor neuron in the hypoglossal nucleus and to induce synthesis of a specific enzyme (Cre recombinase)
Foltán, René. "Genioglossus advancement v chirurgické terapii obstrukčního spánkového apnoického syndromu". Doctoral thesis, 2007. http://www.nusl.cz/ntk/nusl-288576.
Pełny tekst źródłaMoore, Wayne Allen. "Acute and chronic effects of artificial rearing on rat genioglossus muscle /". 2005. http://hdl.handle.net/10156/1544.
Pełny tekst źródłaPark, Eileen. "Sedatives may suppress arousal while allowing greater genioglossus activity during sleep". 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=450599&T=F.
Pełny tekst źródłaWilkinson, Vanessa Elizabeth. "Activity of genioglossus motor units over sleep onset and arousal from sleep". 2010. http://repository.unimelb.edu.au/10187/8538.
Pełny tekst źródłaAoki, Cynthia R. A. "Activating the cAMP-PKA pathway modulates genioglossus muscle and responses to excitatory inputs". 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=370387&T=F.
Pełny tekst źródłaSood, Sandeep Kumar. "Serotonergic neuromodulation of hypoglossal motor output to genioglossus muscle studied by in-vivo microdialysis /". 2006. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=442610&T=F.
Pełny tekst źródłaStadler, Daniel Lajos. "Obesity effects on lung volume, transdiaphragmatic pressure, upper airway dilator and inspiratory pump muscle activity in obstructive sleep apnoea". 2010. http://hdl.handle.net/2440/60527.
Pełny tekst źródłaThesis (Ph.D.) -- University of Adelaide, School of Medical Sciences, 2010
Vecchio, Laura Marie. "State-dependent Versus Central Motor Effects of Ethanol on Breathing". Thesis, 2009. http://hdl.handle.net/1807/18948.
Pełny tekst źródłaSteenland, Hendrick William. "Respiratory activation of the genioglossus muscle involves both non-NMDA and NMDA glutamate receptors at the hypoglossal motor nucleus in-vivo". 2005. http://link.library.utoronto.ca/eir/EIRdetail.cfm?Resources__ID=370469&T=F.
Pełny tekst źródłaStanek, IV Edward John. "Premotor Mechanisms for Orofacial Coordination". Diss., 2016. http://hdl.handle.net/10161/12829.
Pełny tekst źródłaThe mouth, throat, and face contain numerous muscles that participate in a large variety of orofacial behaviors. The jaw and tongue can move independently, and thus require a high degree of coordination among the muscles that move them to prevent self-injury. However, different orofacial behaviors require distinct patterns of coordination between these muscles. The method through which motor control circuitry might coordinate this activity has yet to be determined. Electrophysiological, immunohistochemical, and retrograde tracing studies have attempted to identify populations of premotor neurons which directly send information to orofacial motoneurons in an effort to identify sources of coordination. Yet these studies have not provided a complete picture of the population of neurons which monosynaptically connect to jaw and tongue motoneurons. Additionally, while many of these studies have suggested that premotor neurons projecting to multiple motor pools may play a role in coordination of orofacial muscles, no clear functional roles for these neurons in the coordination of natural orofacial movements has been identified.
In this dissertation, I took advantage of the recently developed monosynaptic rabies virus to trace the premotor circuits for the jaw-closing masseter muscle and tongue-protruding genioglossus muscle in the neonatal mouse, uncovering novel premotor inputs in the brainstem. Furthermore, these studies identified a set of neurons which form boutons onto motor neurons in multiple motor pools, providing a premotor substrate for orofacial coordination. I then combined a retrogradely traveling lentivirus with a split-intein mediated split-Cre recombinase system to isolate and manipulate a population of neurons which project to both left and right jaw-closing motor nuclei. I found that these bilaterally projecting neurons also innervate multiple other orofacial motor nuclei, premotor regions, and midbrain regions implicated in motor control. I anatomically and physiologically characterized these neurons and used optogenetic and chemicogenetic approaches to assess their role in natural jaw-closing behavior, specifically with reference to bilateral masseter muscle electromyogram (EMG) activity. These studies identified a population of bilaterally projecting neurons in the supratrigeminal nucleus as essential for maintenance of an appropriate level of masseter activation during natural chewing behavior in the freely moving mouse. Moreover, these studies uncovered two distinct roles of supratrigeminal bilaterally projecting neurons in bilaterally synchronized activation of masseter muscles, and active balancing of bilateral masseter muscle tone against an excitatory input. Together, these studies identify neurons which project to multiple motor nuclei as a mechanism by which the brain coordinates orofacial muscles during natural behavior.
Dissertation