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Artykuły w czasopismach na temat „GdCoO3”

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Data publikacji: 6 września 2023

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1

Dudnikov, V. A., D. A. Velikanov, N. V. Kazak, C. R. Michel, J. Bartolome, A. Arauzo, S. G. Ovchinnikov i G. S. Patrin. "Antiferromagnetic ordering in REM cobaltite GdCoO3". Physics of the Solid State 54, nr 1 (styczeń 2012): 79–83. http://dx.doi.org/10.1134/s106378341201009x.

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Duparc, Marion, Henrik Hovde Sønsteby, Ola Nilsen, Anja Olafsen Sjåstad i Helmer Fjellvåg. "Atomic Layer Deposition of GdCoO3 and Gd0.9Ca0.1CoO3". Materials 13, nr 1 (19.12.2019): 24. http://dx.doi.org/10.3390/ma13010024.

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Thin films of the catalytically interesting ternary and quaternary perovskites GdCoO3 and Gd0.9Ca0.1CoO3 are fabricated by atomic layer deposition using metal β-diketonates and ozone as precursors. The resulting thin films are amorphous as deposited and become single-oriented crystalline on LaAlO3(100) and YAlO3(100/010) after post-annealing at 650 °C in air. The crystal orientations of the films are tunable by choice and the orientation of the substrate, mitigated through the interface via solid face epitaxy upon annealing. The films exhibit no sign of Co2+. Additionally, high-aspect-ratio Si(100) substrates were used to document the suitability of the developed process for the preparation of coatings on more complex, high-surface-area structures. We believe that coatings of GdCoO3 and Gd1−xCaxCoO3 may find applications within oxidation catalysis.
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Pillai, C. G. S., i A. M. George. "High-temperature thermal conductivity of NdCoO3 and GdCoO3". International Journal of Thermophysics 12, nr 1 (styczeń 1991): 207–21. http://dx.doi.org/10.1007/bf00506132.

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4

Mahata, Partha, T. Aarthi, Giridhar Madras i Srinivasan Natarajan. "Photocatalytic Degradation of Dyes and Organics with Nanosized GdCoO3". Journal of Physical Chemistry C 111, nr 4 (luty 2007): 1665–74. http://dx.doi.org/10.1021/jp066302q.

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5

ЛОПАТИН, С. И., И. А. ЗВЕРЕВА i И. В. ЧИСЛОВА. "ПАРООБРАЗОВАНИЕ И ТЕРМОДИНАМИЧЕСКИЕ СВОЙСТВА СЛОЖНЫХ ОКСИДОВ GDFEO3 И GDCOO3". Журнал Общей Химии 90, nr 8 (1.08.2020): 1297–303. http://dx.doi.org/10.31857/s0044460x20080181.

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6

Dong, Q. Y., K. Y. Hou, X. Q. Zhang, L. Su, L. C. Wang, Y. J. Ke, H. T. Yan i Z. H. Cheng. "Giant reversible magnetocaloric effect in antiferromagnetic rare-earth cobaltite GdCoO3". Journal of Applied Physics 127, nr 3 (21.01.2020): 033904. http://dx.doi.org/10.1063/1.5132864.

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7

Lopatin, S. I., I. A. Zvereva i I. V. Chislova. "Vaporization and Thermodynamic Properties of GdFeO3 and GdCoO3 Complex Oxides". Russian Journal of General Chemistry 90, nr 8 (sierpień 2020): 1495–500. http://dx.doi.org/10.1134/s1070363220080174.

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8

Bucur, Raul Alin, Iuliana Badea, Alexandra Ioana Bucur i Stefan Novaconi. "Dielectric, ferroelectric and piezoelectric proprieties of GdCoO3 doped (K0.5Na0.5)NbO3". Journal of Alloys and Compounds 630 (maj 2015): 43–47. http://dx.doi.org/10.1016/j.jallcom.2015.01.030.

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9

Zhang, Liqin, Haifeng Chen, Yaohua Xu, Peisong Tang, Yanhua Tong i Yangbin Ding. "Preparation of GdCoO3 by Sol-Gel Method and Its Photocatalytic Activity". Integrated Ferroelectrics 219, nr 1 (2.09.2021): 204–10. http://dx.doi.org/10.1080/10584587.2021.1911367.

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10

Lenka, R. K., T. Mahata, P. K. Patro, A. K. Tyagi i P. K. Sinha. "Synthesis and characterization of GdCoO3 as a potential SOFC cathode material". Journal of Alloys and Compounds 537 (październik 2012): 100–105. http://dx.doi.org/10.1016/j.jallcom.2012.05.061.

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11

Ivanova, N. B., Juan Bartolomé, A. Figueroa, J. Blasco, Ana B. Arauzo, M. S. Platunov, V. V. Rudenko i N. V. Kazak. "The Influence of Ca Substitution on Magnetic and Electric Properties of GdCoO3- δ Cobaltite". Solid State Phenomena 168-169 (grudzień 2010): 501–4. http://dx.doi.org/10.4028/www.scientific.net/ssp.168-169.501.

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The polycrystal samples of Gd1-xCaxCoO3-δ with different content of Ca were synthesized by three different techniques: solution method, solid state reaction and a sol-gel method. A study of magnetic and electric properties have been made. It is shown that the magnetic properties of this compound are in a high degree close to the same of the parent GdCoO3 with Co3+ ions being in a low spin state below the room temperature. The conductivity investigation revealed its increase by alkaline-earth substitution typical in rare-earth cobaltites.
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12

Ivanova, N. B., N. V. Kazak, C. R. Michel, A. D. Balaev i S. G. Ovchinnikov. "Low-temperature magnetic behavior of the rare-earth cobaltites GdCoO3 and SmCoO3". Physics of the Solid State 49, nr 11 (listopad 2007): 2126–31. http://dx.doi.org/10.1134/s1063783407110182.

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13

Dudnikov, Vyacheslav A., Yuri S. Orlov, Leonid A. Solovyov, Sergey N. Vereshchagin, Sergey Yu Gavrilkin, Alexey Yu Tsvetkov, Dmitriy A. Velikanov, Michael V. Gorev, Sergey V. Novikov i Sergey G. Ovchinnikov. "Effect of Multiplicity Fluctuation in Cobalt Ions on Crystal Structure, Magnetic and Electrical Properties of NdCoO3 and SmCoO3". Molecules 25, nr 6 (12.03.2020): 1301. http://dx.doi.org/10.3390/molecules25061301.

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The structural, magnetic, electrical, and dilatation properties of the rare-earth NdCoO3 and SmCoO3 cobaltites were investigated. Their comparative analysis was carried out and the effect of multiplicity fluctuations on physical properties of the studied cobaltites was considered. Correlations between the spin state change of cobalt ions and the temperature dependence anomalies of the lattice parameters, magnetic susceptibility, volume thermal expansion coefficient, and electrical resistance have been revealed. A comparison of the results with well-studied GdCoO3 allows one to single out both the general tendencies inherent in all rare-earth cobaltites taking into account the lanthanide contraction and peculiar properties of the samples containing Nd and Sm.
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14

Orlov, Yuri S., Alexey E. Sokolov, Vyacheslav A. Dudnikov, Karina V. Shulga, Mikhail N. Volochaev, Sergey M. Zharkov, Nikolay P. Shestakov, Maxim A. Vysotin i Sergei G. Ovchinnikov. "Contribution of the Multiplicity Fluctuation in the Temperature Dependence of Phonon Spectra of Rare-Earth Cobaltites". Molecules 25, nr 18 (20.09.2020): 4316. http://dx.doi.org/10.3390/molecules25184316.

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We have studied, both experimentally and theoretically, the unusual temperature dependence of the phonon spectra in NdCoO3, SmCoO3 and GdCoO3, where the Co3+ ion is in the low-spin (LS) ground state, and at the finite temperature, the high-spin (HS) term has a nonzero concentration nHS due to multiplicity fluctuations. We measured the absorption spectra in polycrystalline and nanostructured samples in the temperature range 3–550 K and found a quite strong breathing mode softening that cannot be explained by standard lattice anharmonicity. We showed that the anharmonicity in the electron–phonon interaction is responsible for this red shift proportional to the nHS concentration.
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15

Ovchinnikov, S. G., Yu S. Orlov i V. A. Dudnikov. "Temperature and field dependent electronic structure and magnetic properties of LaCoO3 and GdCoO3". Journal of Magnetism and Magnetic Materials 324, nr 21 (październik 2012): 3584–87. http://dx.doi.org/10.1016/j.jmmm.2012.02.096.

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16

Mochinaga, Ryoichi, i Tsuyoshi Arakawa. "The gas-sensing of GdCoO3/MOx (M = transition metals) element having a heterojunction". Sensors and Actuators B: Chemical 77, nr 1-2 (czerwiec 2001): 196–99. http://dx.doi.org/10.1016/s0925-4005(01)00730-4.

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17

Ovchinnikov, S. G., Yu S. Orlov, A. A. Kuzubov, V. A. Dudnikov, A. E. Sokolov, V. N. Zabluda, S. B. Naumov i N. P. Shestakov. "Giant red shift of the absorption spectra due to nonstoichiometry in GdCoO3–δ". JETP Letters 103, nr 3 (luty 2016): 161–66. http://dx.doi.org/10.1134/s0021364016030115.

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18

Michel, Carlos R., i Alma H. Martínez-Preciado. "New photosensing properties of nanostructured GdCoO3 in the ultraviolet (A)-visible-near infrared range". Optical Materials 124 (luty 2022): 111968. http://dx.doi.org/10.1016/j.optmat.2022.111968.

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19

Dudnikov, V. A., S. G. Ovchinnikov, Yu S. Orlov, N. V. Kazak, C. R. Michel, G. S. Patrin i G. Yu Yurkin. "Contribution of Co3+ ions to the high-temperature magnetic and electrical properties of GdCoO3". Journal of Experimental and Theoretical Physics 114, nr 5 (maj 2012): 841–49. http://dx.doi.org/10.1134/s106377611203003x.

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20

Michel, Carlos R., Alma H. Martínez, Fátima Huerta-Villalpando i Juan P. Morán-Lázaro. "Carbon dioxide gas sensing behavior of nanostructured GdCoO3 prepared by a solution-polymerization method". Journal of Alloys and Compounds 484, nr 1-2 (wrzesień 2009): 605–11. http://dx.doi.org/10.1016/j.jallcom.2009.05.003.

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21

Yulizar, Yoki, Ananda Eprasatya, Dewangga Oky Bagus Apriandanu i Rika Tri Yunarti. "Facile synthesis of ZnO/GdCoO3 nanocomposites, characterization and their photocatalytic activity under visible light illumination". Vacuum 183 (styczeń 2021): 109821. http://dx.doi.org/10.1016/j.vacuum.2020.109821.

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22

Cavalcante, F. H. M., A. W. Carbonari, R. F. L. Malavasi, G. A. Cabrera-Pasca, R. N. Saxena i J. Mestnik-Filho. "Investigation of spin transition in GdCoO3 by measuring the electric field gradient at Co sites". Journal of Magnetism and Magnetic Materials 320, nr 14 (lipiec 2008): e32-e35. http://dx.doi.org/10.1016/j.jmmm.2008.02.033.

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23

Ivanova, N. B., N. V. Kazak, C. R. Michel, A. D. Balaev, S. G. Ovchinnikov, A. D. Vasil’ev, N. V. Bulina i E. B. Panchenko. "Effect of strontium and barium doping on the magnetic state and electrical conductivity of GdCoO3". Physics of the Solid State 49, nr 8 (sierpień 2007): 1498–506. http://dx.doi.org/10.1134/s1063783407080161.

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24

Jia, Jiang-Heng, Ya-Jiao Ke, Xu Li, Hong-Rui Zhang, Zhi-Peng Yu, Zhao-Hua Cheng, Kun Zhai, Zhong-Yuan Liu i Jia-Fu Wang. "A large magnetocaloric effect of GdCoO3−δ epitaxial thin films prepared by a polymer assisted spin-coating method". Journal of Materials Chemistry C 7, nr 47 (2019): 14970–76. http://dx.doi.org/10.1039/c9tc04464g.

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We have investigated the magnetic properties and the magnetocaloric effect of GdCoO3−δ epitaxial thin films which were successfully grown on a (001) LaAlO3 substrate by a simple polymer assisted deposition (PAD) method.
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25

Mohanty, P., B. S. Jacobs, A. R. E. Prinsloo i C. J. Sheppard. "Thermal decomposition of GdCrO4 to GdCrO3: Structure and magnetism". AIP Advances 11, nr 1 (1.01.2021): 015235. http://dx.doi.org/10.1063/9.0000187.

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26

Yafarova, Liliya V., Grigory V. Mamontov, Irina V. Chislova, Oleg I. Silyukov i Irina A. Zvereva. "The Effect of Transition Metal Substitution in the Perovskite-Type Oxides on the Physicochemical Properties and the Catalytic Performance in Diesel Soot Oxidation". Catalysts 11, nr 10 (19.10.2021): 1256. http://dx.doi.org/10.3390/catal11101256.

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The paper is focused on the Fe for Co substitution effect on the redox and catalytic properties in the perovskite structure of GdFeO3. The solid oxides with the composition GdFe1−xCoxO3 (x = 0; 0.2; 0.5; 0.8; 1) were obtained by the sol-gel method and characterized by various methods: X-ray diffraction (XRD), temperature-programmed reduction (H2-TPR), N2 sorption, temperature-programmed desorption of oxygen (TPD-O2), simultaneous thermal analysis (STA), and X-ray photoelectron spectroscopy (XPS). The H2-TPR results showed that an increase in the cobalt content in the GdFe1−xCoxO3 (x = 0; 0.2; 0.5; 0.8; 1) leads to a decrease in the reduction temperature. Using the TPD-O2 and STA methods, the lattice oxygen mobility is increasing in the course of the substitution of Fe for Co. Thus, the Fe substitution in the perovskite leads to an improvement in the oxygen reaction ability. Experiments on the soot oxidation reveal that catalytic oxidation ability increases in the series: GdFe0.5Co0.5O3 ˂ GdFe0.2Co0.8O3 ˂ GdCoO3, which is in good correlation with the increasing oxygen mobility according to H2-TPR, TPD-O2, and STA results. The soot oxidation over GdFeO3 and GdFe0.8Co0.2O3 is not in this range due to the impurities of iron oxides and higher specific surface area.
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27

Gildo-Ortiz, Lorenzo, Verónica M. Rodríguez-Betancourtt, Oscar Blanco-Alonso, Alex Guillén-Bonilla, José T. Guillén-Bonilla, Angel Guillén-Cervantes, J. Santoyo-Salazar i Héctor Guillén-Bonilla. "A simple route for the preparation of nanostructured GdCoO3 via the solution method, as well as its characterization and its response to certain gases". Results in Physics 12 (marzec 2019): 475–83. http://dx.doi.org/10.1016/j.rinp.2018.11.072.

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28

Cordier, Gerhard, Rita Klemens i Barbara Albert. "Das System Gd/Co/B: Darstellung und röntgenographische Charakterisierung von GdCo4B, Gd3Co11B4, GdCoB4 und GdCo12B6". Zeitschrift für anorganische und allgemeine Chemie 633, nr 10 (sierpień 2007): 1603–7. http://dx.doi.org/10.1002/zaac.200700225.

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Stobiecki, T., K. Kowalski i Z. Obuszko. "Charge transfer and Hall effect in amorphous GdCo, GdCoMo and GdFe films". Physica B+C 130, nr 1-3 (maj 1985): 94–96. http://dx.doi.org/10.1016/0378-4363(85)90194-9.

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Lal, H. B., Kanchan Gaur, R. D. Dwivedi i N. Srivastava. "Electrical properties of GdCrO3 ceramic". Journal of Materials Science Letters 8, nr 9 (wrzesień 1989): 1085–86. http://dx.doi.org/10.1007/bf01730495.

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31

Yoshii, K. "Magnetic Properties of Perovskite GdCrO3". Journal of Solid State Chemistry 159, nr 1 (czerwiec 2001): 204–8. http://dx.doi.org/10.1006/jssc.2000.9152.

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32

Yoshie, Hiroshi, i Yoji Nakamura. "Nuclear Magnetic Resonance of GdCo3". Journal of the Physical Society of Japan 57, nr 9 (15.09.1988): 3157–60. http://dx.doi.org/10.1143/jpsj.57.3157.

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33

Jaiswal, Adhish, Raja Das, Suguna Adyanthaya i Pankaj Poddar. "Synthesis and optical studies of GdCrO3 nanoparticles". Journal of Nanoparticle Research 13, nr 3 (25.09.2010): 1019–27. http://dx.doi.org/10.1007/s11051-010-0090-4.

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34

Bibi, Ismat, Sabir Hussain, Farzana Majid, Shagufta Kamal, Sadia Ata, Misbah Sultan, Muhammad Imran Din, Munawar Iqbal i Arif Nazir. "Structural, Dielectric and Magnetic Studies of Perovskite [Gd1−xMxCrO3 (M = La, Co, Bi)] Nanoparticles: Photocatalytic Degradation of Dyes". Zeitschrift für Physikalische Chemie 233, nr 10 (25.10.2019): 1431–45. http://dx.doi.org/10.1515/zpch-2018-1162.

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Abstract Nanoparticles (NPs) of Gd1−xMxCrO3 (M = La, Co, Bi) were synthesized by microemulsion techniques, involving simultaneous single ion substitution philosophy. Structural, magnetic, dielectric properties, morphology, elemental analysis and distribution size of fabricated nano-crystalline were determined. The techniques employed for investigation are X-ray diffraction (XRD), vibrating sample magnetometer (VSM), dielectric measurement and scanning electron microscopy (SEM), energy dispersive X-ray (EDX), photoluminescence (PL) and atomic force microscopy (AFM), respectively. XRD pattern confirm that all the as-synthesized NPs have orthorhombic structure and successfully substituted of different metal ions into the regular crystal structure of GdCrO3. The lattice parameters X-ray density, bulk density, porosity and grain size were calculated from XRD pattern of Gd1−xMxCrO3 (M = La, Co, Bi) substituted and un-substituted GdCrO3. The magnetic hysteresis loop of fabricated product confirmed that the entire sample exhibits ferromagnetic behavior at room temperature. It was also found that the fabricated NPs show excellent photocatalytic activity (PCA) against Congo-red, about 78.24% after 55 min of incubation.
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35

MAJ, Waldemar. "Anomalous magnetoresistivity of amorphous GdCo3 thin films". Journal of Magnetism and Magnetic Materials 89, nr 1-2 (wrzesień 1990): 189–94. http://dx.doi.org/10.1016/0304-8853(90)90725-6.

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36

El-Hagary, M., H. Michor i G. Hilscher. "Magnetic entropy change in GdCo13−xSix intermetallic compounds". Journal of Magnetism and Magnetic Materials 322, nr 19 (październik 2010): 2840–44. http://dx.doi.org/10.1016/j.jmmm.2010.04.039.

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37

Zhang, Xingquan, Yu Sui, Xianjie Wang i Ruishi Xie. "Structure–property relationship of GdCrO3-modified BiFeO3 ceramics". Journal of Alloys and Compounds 610 (październik 2014): 382–87. http://dx.doi.org/10.1016/j.jallcom.2014.05.050.

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38

Cho, Seong Beom. "Set-Wise Differential Interaction between Copy Number Alterations and Gene Expressions of Lower-Grade Glioma Reveals Prognosis-Associated Pathways". Entropy 22, nr 12 (18.12.2020): 1434. http://dx.doi.org/10.3390/e22121434.

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The integrative analysis of copy number alteration (CNA) and gene expression (GE) is an essential part of cancer research considering the impact of CNAs on cancer progression and prognosis. In this research, an integrative analysis was performed with generalized differentially coexpressed gene sets (gdCoxS), which is a modification of dCoxS. In gdCoxS, set-wise interaction is measured using the correlation of sample-wise distances with Renyi’s relative entropy, which requires an estimation of sample density based on omics profiles. To capture correlations between the variables, multivariate density estimation with covariance was applied. In the simulation study, the power of gdCoxS outperformed dCoxS that did not use the correlations in the density estimation explicitly. In the analysis of the lower-grade glioma of the cancer genome atlas program (TCGA-LGG) data, the gdCoxS identified 577 pathway CNAs and GEs pairs that showed significant changes of interaction between the survival and non-survival group, while other benchmark methods detected lower numbers of such pathways. The biological implications of the significant pathways were well consistent with previous reports of the TCGA-LGG. Taken together, the gdCoxS is a useful method for an integrative analysis of CNAs and GEs.
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39

El ganich, H., O. El rhazouani, A. Halimi, M. Mkimel, Y. Ait Ahmed i E. Saad. "Magnetic properties of the perovskite GdCuO3: Monte Carlo simulation". Physics Letters A 412 (październik 2021): 127587. http://dx.doi.org/10.1016/j.physleta.2021.127587.

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40

Dash, Bibhuti B., i S. Ravi. "Structural, magnetic and electrical properties of Fe substituted GdCrO3". Solid State Sciences 83 (wrzesień 2018): 192–200. http://dx.doi.org/10.1016/j.solidstatesciences.2018.07.018.

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41

Akyol, Mustafa. "The role of adding GdCrO3 in multiferroic CoCr2O4 nanoparticles". Journal of Materials Science: Materials in Electronics 30, nr 7 (21.02.2019): 6459–68. http://dx.doi.org/10.1007/s10854-019-00950-9.

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42

Parida, K. M., Amtul Nashim i Saroj Ku Mahanta. "Visible-light driven Gd2Ti2O7/GdCrO3 composite for hydrogen evolution". Dalton Transactions 40, nr 48 (2011): 12839. http://dx.doi.org/10.1039/c1dt11517k.

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43

Mahana, Sudipta, U. Manju i D. Topwal. "GdCrO3: a potential candidate for low temperature magnetic refrigeration". Journal of Physics D: Applied Physics 51, nr 30 (4.07.2018): 305002. http://dx.doi.org/10.1088/1361-6463/aacc98.

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44

Diop, L. V. B., O. Isnard, N. R. Lee-Hone, D. H. Ryan i J. M. Cadogan. "Ferrimagnetism in GdCo12−xFexB6". Journal of Physics: Condensed Matter 25, nr 31 (9.07.2013): 316001. http://dx.doi.org/10.1088/0953-8984/25/31/316001.

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Kishta, Osama A., Peter Goldberg i Sabah N. A. Husain. "Gadolinium Chloride Attenuates Sepsis-Induced Pulmonary Apoptosis and Acute Lung Injury". ISRN Inflammation 2012 (1.11.2012): 1–9. http://dx.doi.org/10.5402/2012/393481.

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Gadolinium chloride (GdCl3), a Kupffer cells inhibitor, attenuates acute lung injury; however, the mechanisms behind this effect are not completely elucidated. We tested the hypothesis that GdCl3 acts through the inhibition of lung parenchymal cellular apoptosis. Two groups of rats were injected intraperitoneally with saline or E. coli lipopolysaccharide. In two additional groups, rats were injected with GdCl3 24 hrs prior to saline or LPS administration. At 12 hrs, lung injury, inflammation, and apoptosis were studied. Lung water content, myeloperoxidase activity, pulmonary apoptosis and mRNA levels of interleukin-1β, -2, -5, -6, -10 and TNF-α rose significantly in LPS-injected animals. Pretreatment with GdCl3 significantly reduced LPS-induced elevation of pulmonary water content, myeloperoxidase activity, cleaved caspase-3 intensity, and attenuated pulmonary TUNEL-positive cells. GdCl3 pre-treatment upregulated IL-1β, -2 and -10 pulmonary gene expression without significantly affecting the others. These results suggest that GdCl3 attenuates acute lung injury through its effects on pulmonary parenchymal apoptosis.
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Jaiswal, Adhish, Raja Das, K. Vivekanand, Tuhin Maity, Priya Mary Abraham, Suguna Adyanthaya i Pankaj Poddar. "Magnetic and dielectric properties and Raman spectroscopy of GdCrO3 nanoparticles". Journal of Applied Physics 107, nr 1 (styczeń 2010): 013912. http://dx.doi.org/10.1063/1.3275926.

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Alqahtani, Aref, Shahid Husain, Anand Somvanshi i Wasi Khan. "Structural, morphological, thermal and optical investigations on Mn doped GdCrO3". Journal of Alloys and Compounds 804 (październik 2019): 401–14. http://dx.doi.org/10.1016/j.jallcom.2019.07.028.

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Tetean, Romulus, Emil Burzo i Liviu Chioncel. "Magnetic properties and electronic structures of GdCo3−xSix compounds". Journal of Alloys and Compounds 430, nr 1-2 (marzec 2007): 19–21. http://dx.doi.org/10.1016/j.jallcom.2006.05.014.

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MATSUOKA, Akiko, Kazuko FUKUSHIMA, Kazuo IGARASHI, Yasuhiko IWADATE i Junichi MOCHINAGA. "Raman Spectra of Molten GdCl3-KCl and GdCl3-NaCl." NIPPON KAGAKU KAISHI, nr 5 (1993): 471–74. http://dx.doi.org/10.1246/nikkashi.1993.471.

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Michels, Monique, Mariane Abatti, Andriele Vieira, Pricila Ávila, Amanda Indalécio Goulart, Heloisa Borges, Emily Córneo, Diogo Dominguini, Tatiana Barichello i Felipe Dal-Pizzol. "Modulation of microglial phenotypes improves sepsis-induced hippocampus-dependent cognitive impairments and decreases brain inflammation in an animal model of sepsis". Clinical Science 134, nr 7 (kwiecień 2020): 765–76. http://dx.doi.org/10.1042/cs20191322.

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Abstract Background: In order to modulate microglial phenotypes in vivo, M1 microglia were depleted by administration of gadolinium chloride and the expression of M2 microglia was induced by IL-4 administration in an animal model of sepsis to better characterize the role of microglial phenotypes in sepsis-induced brain dysfunction. Methods: Wistar rats were submitted to sham or cecal ligation and perforation (CLP) and treated with IL-4 or GdCl3. Animals were submitted to behavioral tests 10 days after surgery. In a separated cohort of animals at 24 h, 3 and 10 days after surgery, hippocampus was removed and cytokine levels, M1/M2 markers and CKIP-1 levels were determined. Results: Modulation of microglia by IL-4 and GdCl3 was associated with an improvement in long-term cognitive impairment. When treated with IL-4 and GdCl3, the reduction of pro-inflammatory cytokines was apparent in almost all analyzed time points. Additionally, CD11b and iNOS were increased after CLP at all time points, and both IL-4 and GdCl3 treatments were able to reverse this. There was a significant decrease in CD11b gene expression in the CLP+GdCl3 group. IL-4 treatment was able to decrease iNOS expression after sepsis. Furthermore, there was an increase of CKIP-1 in the hippocampus of GdCl3 and IL-4 treated animals 10 days after CLP induction. Conclusions: GdCl3 and IL-4 are able to manipulate microglial phenotype in an animal models of sepsis, by increasing the polarization toward an M2 phenotype IL-4 and GdCl3 treatment was associated with decreased brain inflammation and functional recovery.
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