Gotowe bibliografie tematyczne / Gbp2

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Gotowa bibliografia na temat „Gbp2”

Autor: Grafiati

Data publikacji: 6 września 2023

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Artykuły w czasopismach na temat "Gbp2"

Clough, Barbara, Ryan Finethy, Rabia T. Khan, Daniel Fisch, Sarah Jordan, Harshil Patel, Jörn Coers i Eva-Maria Frickel. "C57BL/6 and 129 inbred mouse strains differ in Gbp2 and Gbp2b expression in response to inflammatory stimuli in vivo". Wellcome Open Research 4 (20.08.2019): 124. http://dx.doi.org/10.12688/wellcomeopenres.15329.1.

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Background: Infections cause the production of inflammatory cytokines such as Interferon gamma (IFNγ). IFNγ in turn prompts the upregulation of a range of host defence proteins including members of the family of guanylate binding proteins (Gbps). In humans and mice alike, GBPs restrict the intracellular replication of invasive microbes and promote inflammation. To study the physiological functions of Gbp family members, the most commonly chosen in vivo models are mice harbouring loss-of-function mutations in either individual Gbp genes or the entire Gbp gene cluster on mouse chromosome 3. Individual Gbp deletion strains differ in their design, as some strains exist on a pure C57BL/6 genetic background, while other strains contain a 129-derived genetic interval encompassing the Gbp gene cluster on an otherwise C57BL/6 genetic background. Methods: To determine whether the presence of 129 alleles of paralogous Gbps could influence the phenotypes of 129-congenic Gbp-deficient strains, we studied the expression of Gbps in both C57BL/6J and 129/Sv mice following in vivo stimulation with adjuvants and after infection with either Toxoplasma gondii or Shigella flexneri. Results: We show that C57BL/6J relative to 129/Sv mice display moderately elevated expression of Gbp2, but more prominently, are also defective for Gbp2b (formerly Gbp1) mRNA induction upon immune priming. Notably, Toxoplasma infections induce robust Gbp2b protein expression in both strains of mice, suggestive of a Toxoplasma-activated mechanism driving Gbp2b protein translation. We further find that the higher expression of Gbp2b mRNA in 129/Sv mice correlates with a gene duplication event at the Gbp2b locus resulting in two copies of the Gbp2b gene on the haploid genome of the 129/Sv strain. Conclusions: Our findings demonstrate functional differences between 129 and C57BL/6 Gbp alleles which need to be considered in the design and interpretation of studies utilizing mouse models, particularly for phenotypes influenced by Gbp2 or Gbp2b expression.

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Feeley, Eric M., Danielle M. Pilla-Moffett, Erin E. Zwack, Anthony S. Piro, Ryan Finethy, Joseph P. Kolb, Jennifer Martinez, Igor E. Brodsky i Jörn Coers. "Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems". Proceedings of the National Academy of Sciences 114, nr 9 (13.02.2017): E1698—E1706. http://dx.doi.org/10.1073/pnas.1615771114.

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Many invasive bacteria establish pathogen-containing vacuoles (PVs) as intracellular niches for microbial growth. Immunity to these infections is dependent on the ability of host cells to recognize PVs as targets for host defense. The delivery of several host defense proteins to PVs is controlled by IFN-inducible guanylate binding proteins (GBPs), which themselves dock to PVs through poorly characterized mechanisms. Here, we demonstrate that GBPs detect the presence of bacterial protein secretion systems as “patterns of pathogenesis” associated with PVs. We report that the delivery of GBP2 to Legionella-containing vacuoles is dependent on the bacterial Dot/Icm secretion system, whereas the delivery of GBP2 to Yersinia-containing vacuoles (YCVs) requires hypersecretion of Yersinia translocon proteins. We show that the presence of bacterial secretion systems directs cytosolic carbohydrate-binding protein Galectin-3 to PVs and that the delivery of GBP1 and GBP2 to Legionella-containing vacuoles or YCVs is substantially diminished in Galectin-3–deficient cells. Our results illustrate that insertion of bacterial secretion systems into PV membranes stimulates Galectin-3–dependent recruitment of antimicrobial GBPs to PVs as part of a coordinated host defense program.

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Legewie, Larissa, Jennifer Loschwitz, Nora Steffens, Martin Prescher, Xue Wang, Sander H. J. Smits, Lutz Schmitt, Birgit Strodel, Daniel Degrandi i Klaus Pfeffer. "Biochemical and structural characterization of murine GBP7, a guanylate binding protein with an elongated C-terminal tail". Biochemical Journal 476, nr 21 (5.11.2019): 3161–82. http://dx.doi.org/10.1042/bcj20190364.

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Abstract Guanylate-binding proteins (GBPs) constitute a family of interferon-inducible guanosine triphosphatases (GTPases) that are key players in host defense against intracellular pathogens ranging from protozoa to bacteria and viruses. So far, human GBP1 and GBP5 as well as murine GBP2 (mGBP2) have been biochemically characterized in detail. Here, with murine GBP7 (mGBP7), a GBP family member with an unconventional and elongated C-terminus is analyzed. The present study demonstrates that mGBP7 exhibits a concentration-dependent GTPase activity and an apparent GTP turnover number of 20 min−1. In addition, fluorescence spectroscopy analyses reveal that mGBP7 binds GTP with high affinity (KD = 0.22 µM) and GTPase activity assays indicate that mGBP7 hydrolyzes GTP to GDP and GMP. The mGBP7 GTPase activity is inhibited by incubation with γ-phosphate analogs and a K51A mutation interfering with GTP binding. SEC-MALS analyses give evidence that mGBP7 forms transient dimers and that this oligomerization pattern is not influenced by the presence of nucleotides. Moreover, a structural model for mGBP7 is provided by homology modeling, which shows that the GTPase possesses an elongated C-terminal (CT) tail compared with the CaaX motif-containing mGBP2 and human GBP1. Molecular dynamics simulations indicate that this tail has transmembrane characteristics and, interestingly, confocal microscopy analyses reveal that the CT tail is required for recruitment of mGBP7 to the parasitophorous vacuole of Toxoplasma gondii.

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Srinivasachar Badarinarayan, Smitha, Irina Shcherbakova, Simon Langer, Lennart Koepke, Andrea Preising, Dominik Hotter, Frank Kirchhoff, Konstantin M. J. Sparrer, Gunnar Schotta i Daniel Sauter. "HIV-1 infection activates endogenous retroviral promoters regulating antiviral gene expression". Nucleic Acids Research 48, nr 19 (6.10.2020): 10890–908. http://dx.doi.org/10.1093/nar/gkaa832.

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Abstract Although endogenous retroviruses (ERVs) are known to harbor cis-regulatory elements, their role in modulating cellular immune responses remains poorly understood. Using an RNA-seq approach, we show that several members of the ERV9 lineage, particularly LTR12C elements, are activated upon HIV-1 infection of primary CD4+ T cells. Intriguingly, HIV-1-induced ERVs harboring transcription start sites are primarily found in the vicinity of immunity genes. For example, HIV-1 infection activates LTR12C elements upstream of the interferon-inducible genes GBP2 and GBP5 that encode for broad-spectrum antiviral factors. Reporter assays demonstrated that these LTR12C elements drive gene expression in primary CD4+ T cells. In line with this, HIV-1 infection triggered the expression of a unique GBP2 transcript variant by activating a cryptic transcription start site within LTR12C. Furthermore, stimulation with HIV-1-induced cytokines increased GBP2 and GBP5 expression in human cells, but not in macaque cells that naturally lack the GBP5 gene and the LTR12C element upstream of GBP2. Finally, our findings suggest that GBP2 and GBP5 have already been active against ancient viral pathogens as they suppress the maturation of the extinct retrovirus HERV-K (HML-2). In summary, our findings uncover how human cells can exploit remnants of once-infectious retroviruses to regulate antiviral gene expression.

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Yu, Peifa, Yang Li, Yunlong Li, Zhijiang Miao, Maikel P. Peppelenbosch i Qiuwei Pan. "Guanylate-binding protein 2 orchestrates innate immune responses against murine norovirus and is antagonized by the viral protein NS7". Journal of Biological Chemistry 295, nr 23 (30.04.2020): 8036–47. http://dx.doi.org/10.1074/jbc.ra120.013544.

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Noroviruses are the main causative agents of acute viral gastroenteritis, but the host factors that restrict their replication remain poorly identified. Guanylate-binding proteins (GBPs) are interferon (IFN)-inducible GTPases that exert broad antiviral activity and are important mediators of host defenses against viral infections. Here, we show that both IFN-γ stimulation and murine norovirus (MNV) infection induce GBP2 expression in murine macrophages. Results from loss- and gain-of-function assays indicated that GBP2 is important for IFN-γ–dependent anti-MNV activity in murine macrophages. Ectopic expression of MNV receptor (CD300lf) in human HEK293T epithelial cells conferred susceptibility to MNV infection. Importantly, GBP2 potently inhibited MNV in these human epithelial cells. Results from mechanistic dissection experiments revealed that the N-terminal G domain of GBP2 mediates these anti-MNV effects. R48A and K51A substitutions in GBP2, associated with loss of GBP2 GTPase activity, attenuated the anti-MNV effects of GBP2. Finally, we found that nonstructural protein 7 (NS7) of MNV co-localizes with GBP2 and antagonizes the anti-MNV activity of GBP2. These findings reveal that GBP2 is an important mediator of host defenses against murine norovirus.

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Liu, Bo, Rongfei Huang, Tingting Fu, Ping He, Chengyou Du, Wei Zhou, Ke Xu i Tao Ren. "GBP2 as a potential prognostic biomarker in pancreatic adenocarcinoma". PeerJ 9 (11.05.2021): e11423. http://dx.doi.org/10.7717/peerj.11423.

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Background Pancreatic adenocarcinoma (PAAD) is a disease with atypical symptoms, an unfavorable response to therapy, and a poor outcome. Abnormal guanylate-binding proteins (GBPs) play an important role in the host’s defense against viral infection and may be related to carcinogenesis. In this study, we sought to determine the relationship between GBP2 expression and phenotype in patients with PAAD and explored the possible underlying biological mechanism. Method We analyzed the expression of GBP2 in PAAD tissues using a multiple gene expression database and a cohort of 42 PAAD patients. We evaluated GBP2’s prognostic value using Kaplan–Meier analysis and the Cox regression model. GO and KEGG enrichment analysis, co-expression analysis, and GSEA were performed to illustrate the possible underlying biological mechanism. CIBERSORT and the relative expression of immune checkpoints were used to estimate the relationship between GBP2 expression and tumor immunology. Result GBP2 was remarkably overexpressed in PAAD tissue. The overexpression of GBP2 was correlated with an advanced T stage and poor overall survival (OS) and GBP2 expression was an independent risk factor for OS in PAAD patients. Functional analysis demonstrated that positively co-expressed genes of GBP2 were closely associated with pathways in cancer and the NOD-like receptor signaling pathway. Most of the characteristic immune checkpoints, including PDCD1, PDCDL1, CTLA4, CD80, TIGIT, LAG3, IDO2, and VISTA, were significantly expressed in the high-GBP2 expression group compared with the low-GBP2 expression group. Conclusion GBP2 acted as a potential prognostic biomarker and was associated with immune infiltration and the expression of immune checkpoints in PAAD.

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Ohshima, Jun, Miwa Sasai, Jianfa Liu, Kazuo Yamashita, Ji Su Ma, Youngae Lee, Hironori Bando i in. "RabGDIα is a negative regulator of interferon-γ–inducible GTPase-dependent cell-autonomous immunity to Toxoplasma gondii". Proceedings of the National Academy of Sciences 112, nr 33 (3.08.2015): E4581—E4590. http://dx.doi.org/10.1073/pnas.1510031112.

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IFN-γ orchestrates cell-autonomous host defense against various intracellular vacuolar pathogens. IFN-γ–inducible GTPases, such as p47 immunity-related GTPases (IRGs) and p65 guanylate-binding proteins (GBPs), are recruited to pathogen-containing vacuoles, which is important for disruption of the vacuoles, culminating in the cell-autonomous clearance. Although the positive regulation for the proper recruitment of IRGs and GBPs to the vacuoles has been elucidated, the suppressive mechanism is unclear. Here, we show that Rab GDP dissociation inhibitor α (RabGDIα), originally identified as a Rab small GTPase inhibitor, is a negative regulator of IFN-γ–inducible GTPases in cell-autonomous immunity to the intracellular pathogen Toxoplasma gondii. Overexpression of RabGDIα, but not of RabGDIβ, impaired IFN-γ–dependent reduction of T. gondii numbers. Conversely, RabGDIα deletion in macrophages and fibroblasts enhanced the IFN-γ–induced clearance of T. gondii. Furthermore, upon a high dose of infection by T. gondii, RabGDIα-deficient mice exhibited a decreased parasite burden in the brain and increased resistance in the chronic phase than did control mice. Among members of IRGs and GBPs important for the parasite clearance, Irga6 and Gbp2 alone were more frequently recruited to T. gondii-forming parasitophorous vacuoles in RabGDIα-deficient cells. Notably, Gbp2 positively controlled Irga6 recruitment that was inhibited by direct and specific interactions of RabGDIα with Gbp2 through the lipid-binding pocket. Taken together, our results suggest that RabGDIα inhibits host defense against T. gondii by negatively regulating the Gbp2–Irga6 axis of IFN-γ–dependent cell-autonomous immunity.

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Zhang, Juan, Yu Zhang, Wenshuang Wu, Fang Wang, Xinyu Liu, Guanghou Shui i Chunlai Nie. "Guanylate-binding protein 2 regulates Drp1-mediated mitochondrial fission to suppress breast cancer cell invasion". Cell Death & Disease 8, nr 10 (październik 2017): e3151-e3151. http://dx.doi.org/10.1038/cddis.2017.559.

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Abstract Guanylate-binding protein 2 (GBP2) is a member of the large GTPase superfamily that is strongly induced by interferon-γ (IFN-γ). Although the biochemical characteristics of GBP2 have been reported in detail, its biological function has not been thoroughly elucidated to date. To the best of our knowledge, this study presents the first demonstration that GBP2 inhibits mitochondrial fission and cell metastasis in breast cancer cells both in vitro and in vivo. Our previous work demonstrated that dynamin-related protein 1 (Drp1)-dependent mitochondrial fission has a key role in breast cancer cell invasion. In this study, we demonstrate that GBP2 binds directly to Drp1. Elimination of Drp1 by shRNA or Mdivi-1 (a Drp1-specific inhibitor) suppressed GBP2’s regulatory function. Furthermore, GBP2 blocks Drp1 translocation from the cytosol to mitochondria, thereby attenuating Drp1-dependent mitochondrial fission and breast cancer cell invasion. In summary, our data provide new insights into the function and molecular mechanisms underlying GBP2’s regulation of breast cancer cell invasion.

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Ma, Guojian, Jing Huang, Nunu Sun, Xiangdong Liu, Mengjin Zhu, Zhenfang Wu i Shuhong Zhao. "Molecular characterization of the porcine GBP1 and GBP2 genes". Molecular Immunology 45, nr 10 (maj 2008): 2797–807. http://dx.doi.org/10.1016/j.molimm.2008.02.007.

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Wang, Haizhou, Yabo Zhou, Yangyang Zhang, Shilin Fang, Meng Zhang, Haiou Li, Fei Xu i in. "Subtyping of microsatellite stability colorectal cancer reveals guanylate binding protein 2 (GBP2) as a potential immunotherapeutic target". Journal for ImmunoTherapy of Cancer 10, nr 4 (kwiecień 2022): e004302. http://dx.doi.org/10.1136/jitc-2021-004302.

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BackgroundsProficient-mismatch-repair or microsatellite stability (pMMR/MSS) colorectal cancer (CRC) has limited efficacy for immune checkpoint blockade (ICB) therapy and its underlying mechanism remains unclear. Guanylate binding protein 2 (GBP2) is a member of the GTPase family and is crucial to host immunity against pathogens. However, the correlations between GBP2 and immunosurveillance and immunotherapy for pMMR/MSS CRC have not been reported.MethodsUnsupervised clustering was employed to classify immune class and non-immune class in 1424 pMMR/MSS patients from six independent public datasets. This binary classification was validated using immune cells or response related signatures. The correlation between GBP2 and immune microenvironment was explored using well-established biological algorithms, multiplex immunohistochemistry (mIHC), in vitro and in vivo experiments.ResultsWe classified 1424 pMMR/MSS CRC patients into two classes, ‘immune’ and ‘non-immune’, and GBP2 was identified as a gene of interest. We found that lower GBP2 expression was correlated with poor prognosis and metastasis. GBP2 expression was also upregulated in the immune class and highly associated with interferon-γ (IFN-γ) signaling pathway and CD8 +T cell infiltration using gene set enrichment analysis, gene ontology analysis, single-cell sequencing and mIHC. Moreover, reduced GBP2 expression inhibited the antigen processing and presentation machinery and CXCL10/11 expression in MSS CRC cells on IFN-γ stimulation. A Transwell assay revealed that deletion of GBP2 in murine MSS CRC cells reduced CD8 +T cell migration. Mechanistically, GBP2 promoted signal transducer and transcription activator 1 (STAT1) phosphorylation by competing with SHP1 for binding to STAT1 in MSS CRC cells. Finally, an unsupervised subclass mapping (SubMap) algorithm showed that pMMR/MSS patients with high GBP2 expression may correlate with a favorable response to anti-PD-1 therapy. We further confirmed that GBP2 knockout reduced CD8 +T cell infiltration and blunted the efficacy of PD-1 blockade in tumor-bearing mice.ConclusionsOur study reveals that pMMR/MSS CRC is immunogenically heterogeneous and that GBP2 is a promising target for combinatorial therapy with ICB.

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Rozprawy doktorskie na temat "Gbp2"

Grosse, Sebastian [Verfasser]. "Gbp2 and Hrb1 continue their mRNA quality control in the cytoplasm and take part in Nonsense Mediated Decay / Sebastian Grosse". Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2019. http://d-nb.info/1216703647/34.

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Janning, Melanie Christiane [Verfasser], i Heike [Akademischer Betreuer] Krebber. "Identifizierung von neuen Faktoren des Gbp2-assoziierten mRNA-Exportes und den Untersuchungen an mRNA-bindenden Proteinen im Modellorganismus Saccharomyces cerevisiae. / Melanie Christiane Janning ; Betreuer: Heike Krebber". Marburg : Philipps-Universität Marburg, 2017. http://d-nb.info/1133261795/34.

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Karaki, Julie. "100 Gbps coherent MB-OFDM for long-haul WDM optical transmission". Thesis, Paris, ENST, 2013. http://www.theses.fr/2013ENST0019/document.

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Aujourd'hui, le format « Quadrature Phase Shift Keying » avec multiplexage de polarisation (DP-QPSK) opérant à 100 Gbps est devenue un standard pour la transmission WDM longue distance. Une alternative au format DP-QPSK permettant d’atteindre des débits de 100 Gbps et plus (400 G & 1Tbps) est l’ « Orthogonal Frequency Division Multiplexing » (OFDM). Mais, des interrogations subsistent quant à sa robustesse aux effets non linéaires. Dans cette thèse nous avons étudié le potentiel de la technologie OFDM pour la transmission WDM longue distance à 100 Gbps. Le traitement du signal est détaillé ainsi que la mise en œuvre du transmetteur et récepteur OFDM cohérent. Nous présentons aussi les résultats expérimentaux de la transmission obtenus dans plusieurs configurations. Dans l’une de ces configurations, le canal modulé avec le format DP-OFDM coherent (Co-DP-OFDM) est multiplexé avec 40 canaux modulés en DP-QPSK à 100 Gbps. Les canaux ont ensuite été transmis sur 1000 km de fibre G.652 sans gestion de dispersion chromatique. Dans une autre configuration, les canaux Co-DP-OFDM et Co-DP-QPSK sont combinés avec 78 canaux 10 Gbps NRZ-OOK et transmis sur 1000 km de fibre G.652 avec gestion de dispersion. Nous avons montré que le Co-DP-OFDM et Co-DP-QPSK ont des performances similaires après une transmission de 1000 km sur une ligne sans gestion de dispersion, et nous avons aussi montré que la transmission de ces formats sur une infrastructure de fibre deployée est possible à condition de réduire de 5 dB la puissance des canaux 10 Gbps NRZ-OOK par rapport aux canaux à100 Gbps. Ces résultats sont précieux pour la prochaine génération de systèmes WDM à 400 Gbps ou 1 Tbps
Today the 100 Gbps coherent dual polarization quadrature phase shift keying (Co-DP-QPSK) is standardized as the industrial solution for long-haul WDM transmission. Another alternative format to DP-QPSK that permits also to reach a data rate of 100 Gbps and beyond is the coherent orthogonal frequency division multiplexing (OFDM) format. However a doubt exists over the ability of OFDM to be as efficient as QPSK for long-haul WDM transmission due to its supposed higher sensitivity to nonlinear effects . In this thesis, we have investigated the potential of Co-DP-OFDM for 100 Gbps WDM transport. The digital signal processing algorithms are detailed as well as the various experimental set-ups required to carry out and validate the 100 Gbps transceiver. We also present the transmission results obtained with several configurations. In one of these configurations, the 100 Gbps Co-DP-OFDM channel is multiplexed with forty 100 Gbps DP-QPSK channels and all these channels are transmitted over 1000 km of DCF-free G.652 fiber, while in another configuration, the Co-DP-OFDM and Co-DP-QPSK channels are combined with seventy eight 10 Gbps NRZ-OOK channels and transmitted over 1000 km of dispersion managed G.652 fiber line. We have demonstrated that OFDM and QPSK have nearly the same performance after a transmission over 1000 km, and also we have demonstrated that the transmission of these two formats over legacy fiber infrastructure is possible under the condition of decreasing by 5 dB the 10 Gbps NRZ-OOK channel power with respect to the 100 Gbps channels. The results presented in this thesis are very valuable when considering the next generation of 400 Gbps or 1 Tbps for WDM systems

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Gray, Andrew, Parminder Ghuman i Scott Hoy. "Multi-Gbps 16-QAM All-Digital Parallel Receiver". International Foundation for Telemetering, 2001. http://hdl.handle.net/10150/607665.

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International Telemetering Conference Proceedings / October 22-25, 2001 / Riviera Hotel and Convention Center, Las Vegas, Nevada
Due to rapidly increasing downlink data rates between spacecraft and ground stations, the National Aeronautics and Space Administration (NASA) has developed an all-digital variable data rate receiver. The majority of the receiver is implemented on a single complementary metal oxide semiconductor (CMOS) application specific integrated circuit (ASIC) that is capable of processing data rates in excess of 300 mega-symbols per second or 600 mega-bits per second (Mbps) using quadrature phase-shift keyed (QPSK) modulation [1-5]. Developed jointly by the Goddard Space Flight Center and the Jet Propulsion Laboratory, the high rate digital demodulator (HRDD) ASIC uses parallel processing algorithms, which combined we call the advanced parallel receiver architecture (APRX), to perform the necessary functions of a satellite communications receiver. An overview of the next generation of the advanced parallel receiver architecture (APRX) is presented here, including a new parallel adaptive equalizer currently being implemented. The next generation receiver implementing this architecture will process in excess of 600 Megasymbols per second; the ASIC will process in excess of 1.2 Gbps using quadrature amplitude modulation (QPSK) and 2.4 Gbps using 16-quadrature amplitude modulation (QAM). The majority of the functions of the receiver are performed in the next generation high rate digital demodulator ASIC. A key property of such high data rate wireless communications systems is the use bandwidth efficient modulations often achieved through the use of sophisticated pulseshaping. The next generation ASIC, like the current generation ASIC, is designed to have programmable matched filters. The detection/matched filter bank in the ASIC should be programmed to “match” the received pulse-shape. This is particularly important for good biterror- rate performance in systems employing higher order modulations, such as 16-QAM employing partial-response pulse-shaping spanning many symbols. Such bandwidth efficient pulse-shaping methods require many coefficients in the matched filter; this creates increased computation and complexity in the receiver. Often such ideal receivers are not practical or possible to implement, and sub-optimal detection filtering techniques must be used. We will demonstrate that the use of a sub-optimum or truncated matched filter in some systems introduces severe intersymbol interference (ISI) distortion that results in poor BER results. However, we demonstrate for a specific pulse-shaped 16-QAM that if the demodulated baseband symbols are processed with a relatively simple equalizer very good performance may be achieved. The overall system complexity of such a system may be much lower than implementing the true matched filter [6]. Finally we present an overview of the next generation advanced parallel receiver (APRX) capable of demodulating such pulse-shaped 16-QAM that includes a novel parallel adaptive equalizer.

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Rice, Abigail C. "Design and simulation of a 20 Gbps communication channel". Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/115463.

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Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, June 2015.
"May 2015." Page 113 missing. Cataloged from PDF version of thesis.
Includes bibliographical references (pages 106-107).
Digital wire-line communication speeds are increasing rapidly to achieve ever higher data rates. Speeds beyond 20Gpbs are desirable for the next generation of protocols. However, higher frequency signals experience more loss due to the physical channel and are more sensitive to small imperfections in the channel, such as vias. In this work, an existing communication channel between two controller boards across a midplane was improved to allow for operation at a higher frequency. Mentor Graphics HyperLynx was used to simulate the channel and display S-parameter models and eye diagrams to demonstrate the impact of various designs. The effects of the material properties, impedance of the traces, and vias were simulated and the results combined to determine what physical layer improvements must be made to reduce loss and reflections at this high frequency.
by Abigail C. Rice.
M. Eng.

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Mandhanya, Saurabh. "Single-ended 16x8 Gbps data bus in 90nm CMOS". Pullman, Wash. : Washington State University, 2009. http://www.dissertations.wsu.edu/Thesis/Fall2009/s_mandhanya_081909.pdf.

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Thesis (M.S. in electrical engineering)--Washington State University, December 2009.
Title from PDF title page (viewed on Jan. 21, 2010). "School of Electrical Engineering and Computer Science ." Includes bibliographical references (p. 73-75).

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Ansari, Ashlaghi Aria. "100 GBPS Orthogonal Frequency Division Multiplexing optical fiber communication network". Thesis, California State University, Long Beach, 2015. http://pqdtopen.proquest.com/#viewpdf?dispub=1604879.

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Optical fiber communication has emerged as a high potential substitute for communication methods such as twisted pair and coaxial wire. The main advantage of optical fiber over previous methods is to have higher capacity of data rate transmission. The conventional types of modulation and demodulation technique, which have been used through optical fiber communication system are Wavelength Division Multiplexing (WDM) technique and Dense Wavelength Division Multiplexing (DWDM) technique so far.

In this thesis, the Orthogonal Frequency Division Multiplexing (OFDM) is applied through the modulation and demodulation parts due to some advantages over WDM and DWDM to reach to 100 Gbps data transmission. The main advantage of OFDM-optical fiber is that it only needs one optical source to modulate and one optical source to demodulate the signals at transmitter side and receiver side, which results in a reduction of the cost of the system. Also, by using the OFDM, the chromatic dispersion can be eliminated or decreased.

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Blanár, Josef. "Technická analýza vývoje měnového páru GBP/USD". Master's thesis, Česká zemědělská univerzita v Praze, 2016. http://www.nusl.cz/ntk/nusl-259199.

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This diploma thesis deals with the technical analysis of the development of the currency pair GBP/USD. It is divided into theoretical and analytical part. The theoretical part is used to define the concepts of Forex market and the issue of exchange rates along with the trading terminology according to the relevant specialized literature and internet resources. There is characterized Forex and its subjects, described the main representatives of the kinds of technical indicators and basic graphic formations that can be commonly found in the charts. Analytical part focuses on the formulation of a business plan before the start of trading, as well as the detailed analysis of selected representatives of profitable and unprofitable transactions realized during the simulated trading on a demo account by Bossa FX for the period from October to December 2015. Afterwards there is tested the relation between the success of the realized transactions and used technical analysis tools. The result of the diploma thesis is the total retrospective evaluation of the simulated trading success rate. The output is the formulation of propositions and recommendations to help especially novice traders to make their trading as successful as possible.

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Tyrkalska, Sylwia Dominika. "Caracterizació molecular y funcional de Gbp4 de pez cebra : un nuevo componente del inflamasoma= Molecular and functional chraterization of zebrafish Gbp4: a new inflammasome component". Doctoral thesis, TDR (Tesis Doctorales en Red), 2015. http://hdl.handle.net/10803/310950.

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INTRODUCCIÓN: La señalización a través de los NOD-like receptors (NLRs), que son una familia de receptores citosólicos de reconocimiento de patrones (PRRs), da lugar al procesamiento y activación de las citoquinas pro-inflamatorias IL-1 β e IL-18 mediados por caspasa-1, así como de la inducción de una forma de muerte celular recientemente descrita llamada piroptosis. Para ello, los NLRs median la formación de plataformas multiproteicas de señalización llamadas inflamasomas, que alertan al sistema inmune de la presencia de infección o daño tisular. OBJETIVOS: (1) Establecimiento de un modelo de infección de Salmonella Typhimurium en pez cebra para estudiar la activación, el ensamblaje y el funcionamiento del inflamasoma; (2) Caracterización del papel de la flagelina de S. Typhimurium en el mecanismo de infección en pez cebra; (3) Caracterización del papel de Gbp4 de pez cebra en la activación y ensamblaje del inflamasoma, así como en la eliminación de S. Typhimurium; (4) Caracterización del papel de los neutrófilos en la eliminación de S. Typhimurium dependiente de Gbp4 en pez cebra; (5) Caracterización del papel de Gbp4 en la producción de prostaglandinas dependiente del inflamasoma, y del de las prostaglandinas en la eliminación de S. Typhimurium. METODOLOGÍA: Los métodos utilizados en la tesis doctoral son: Ensayos de infección con S. Typhimurium, ensayos de actividad caspasa-1, toma de imágenes de larvas de pez cebra, reclutamiento de neutrófilos y análisis de la muerte celular, ensayos de luminescencia, citometría de flujo, análisis de expresión génica, Western blot, ensayo de reconstitución del inflamasoma en células HEK293. RESULTADOS: Aquí demostramos que la proteína Gbp4 de pez cebra, una enzima GTPasa inducible por IFNγ que alberga un dominio C-terminal CARD, se expresa en los neutrófilos y es necesaria para la eliminación de Salmonella Typhimurium in vivo dependiente del inflamasoma. A pesar de la presencia del dominio CARD, Gbp4 requiere la presencia de la proteína adaptadora Asc para desempeñar su función antibacteriana. Además, la actividad GTPasa de Gbp4 es indispensable para la activación del inflamasoma, el reclutamiento de neutrófilos al lugar de la infección, y la eliminación de S. Typhimurium. La reconstitución de los complejos Gbp4-Asc en células embrionarias humanas de riñón (HEK293) en cultivo, nos mostró que forman complejos macromoleculares con un anillo exterior de Asc y un núcleo de Gbp4. Mecanísticamente, Gbp4 es esencial para la liberación de prostaglandinas dependiente del inflamasoma, de las cuales PGD2 se asocia con la eliminación de bacterias mediada por Gbp4. Por tanto, nuestros resultados señalan a las proteínas de unión con GTPasa como los adaptadores clave del inflamasoma necesarios para la biosíntesis de prostaglandinas y la eliminación de bacterias intracelulares por los neutrófilos in vivo. CONCLUSIONES: (1) El pez cebra es un excelente modelo para estudiar la activación y la función del inflamasoma en respuesta a una infección por S. Typhimurium; (2) El reconocimiento intracelular de S. Typhimurium en pez cebra depende altamente de la producción de flagelina; (3) La activación del inflamasoma dependiente de Gbp4 mejora la resistencia de las larvas de pez cebra e incrementa la actividad caspasa-1 después de la infección con S. Typhimurium; (4) Tanto Gbp4 mutante que carece de la actividad GTPasa, como el doble mutante al que también le falta el dominio CARD, se comportan como dominantes negativos, incrementando la susceptibilidad a S. Typhimurium y, en paralelo, reduciendo la actividad caspasa-1; (5) El mutante de Gbp4 sin el dominio CARD actúa, al igual que GBP5 de mamíferos, rescatando la elevada susceptibilidad de las larvas deficientes en Gbp4, pero no aumenta la actividad caspasa-1 después de la infección con S. Typhimurium en pez cebra; (6) Gbp4 regula el reclutamiento de neutrófilos al lugar de infección y, además, la eliminación de S. Typhimurium dependiente de Gbp4 esta mediada por los neutrófilos; (7) El inflamasoma dependiente de Gbp4 activa la biosíntesis de las prostaglandinas, que a su vez fomentan la eliminación de S. Typhimurium.
NTRODUCTION: The nucleotide-binding domain leucine-rich repeats (NLRs) constitute a family of cytosolic pattern recognition receptors (PRRs), which are the responsible for the caspase-1-mediated processing and activation of pro-inflammatory cytokines, such us IL-1 β and IL-18, and the induction of a recently described form of cell death called pyroptosis. NLRs achieve these functions by forming multiprotein signaling platforms, called inflammasomes, which alert the immune system about the presence of infection or tissue damage. OBJECTIVES: Taking that into consideration, the objectives of the present work are: (1) Establishment of a zebrafish – Salmonella Typhimurium infection model to study inflammasome activation, assembly and function; (2) Characterization of the role of flagellin of S. Typhimurium in the infection mechanism in zebrafish; (3) Characterization of the role of zebrafish Gbp4 in inflammasome activation, assembly and clearance of S. Typhimurium; (4) Characterization of the role of neutrophils in the Gbp4-dependent clearance of S. Typhimurium in zebrafish; (5) Characterization of the role played by the Gbp4 inflammasome in prostaglandin production and S. Typhimurium clearance. METHODOLOGY: The following methods were used in this doctoral thesis: yolk sac or ear infection assays with S. Typhimurium, caspase-1 activity assays of infected larvae, counting of neutrophils using different zebrafish transgenic lines with fluorescent neutrophils using live imaging, neutrophil recruitment assays, cell death analysis, luminescence assays for the measurement of Il1-β contents, flow cytometry and FACS-sorting of fluorescent cells, gene expression analysis, western blot, inflammasome reconstitution assays in HEK293 cells. RESULTS: Here we report that zebrafish Gbp4, an IFNγ-inducible GTPase harboring a C-terminal CARD domain, is expressed in neutrophils and is required for the inflammasome-dependent clearance of Salmonella Typhimurium in vivo. Despite the presence of the CARD domain, Gbp4 requires the universal inflammasome adaptor protein Asc for mediating its antibacterial function. In addition, the GTPase activity of Gbp4 is indispensable for the inflammasome activation, the neutrophil recruitment and the clearance of S. Typhimurium. Reconstitution of Gbp4-Asc complexes in human embryonic kidney cells (HEK293) revealed a macromolecular complex with an outer ring of Asc and an core of Gbp4. Mechanistically, Gbp4 is essential for the inflammasome-dependent release of prostaglandins, of which PGD2 is associated with the Gbp4-mediated bacterial clearance. Our results, therefore, point to GTPase-binding proteins as the key inflammasome adaptors required for prostaglandin biosynthesis and intracellular bacterial clearance by neutrophils in vivo. CONCLUSIONS: The above results suggest that: (1) Zebrafish is an excellent model to study inflammasome activation and function upon S. Typhimurium infection; (2) Intracellular recognition of S. Typhimurium in zebrafish highly depends on flagellin production; (3) Gbp4-dependent inflammasome activation improves zebrafish larvae resistance and increases caspase-1 activity upon S. Typhimurium infection; (4) A Gbp4 mutant lacking GTPase activity, as well as a double GTPase and CARD mutant, behave as dominant negatives by increasing the susceptibility to S. Typhimurium and, in parallel, decreasing caspase-1 activity; (5) A Gbp4 mutant lacking the CARD domain acts as mammalian GBP5; that is, rescues the higher susceptibility of Gbp4-deficient larvae but fails to increase caspase-1 activity upon S. Typhimurium infection in zebrafish; (6) Gbp4 regulates neutrophil recruitment to the site of the infection. In addition, the Gbp4-dependent clearance of S. Typhimurium is mediated by neutrophils; (7) The Gbp4-dependent inflammasome activates prostaglandin biosynthesis, which in turn promotes S. Typhimurium clearance.

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Katsikas, Georgios P. "Realizing High Performance NFV Service Chains". Licentiate thesis, KTH, Network Systems Laboratory (NS Lab), 2016. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-195352.

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Network functions (NFs) hold a key role in networks, offering in-network services, such as enhanced performance, policy enforcement, and security. Traditionally, NFs have been implemented in specialized, thus expensive hardware. To lower the costs of deploying NFs, network operators have adopted network functions virtualization (NFV), by migrating NFs from hardware to software running in commodity servers. Several approaches to NFV have shown that commodity network stacks and drivers (e.g., Linux-based) struggle to keep up with increasing hardware speed. Despite this, popular networking services still rely on these commodity components. Moreover, chaining NFs (also known as service chaining) is challenging due to redundancy in the elements of the chain. This licentiate thesis addresses the performance problems of NFV service chains.The first contribution is a framework that (i) profiles NFV service chains to uncover performance degradation reasons and (ii) leverages the profiler’s data to accelerate these chains, by combining multiplexing of system calls with scheduling strategies. These accelerations improve the cache utilization and thereby the end-to-end latency of chained NFs is reduced by a factor of three. Moreover, the same chains experience a multi-fold latency variance reduction; this result improves the quality of highly-interactive services.The second contribution of this thesis substantially revises the way NFV service chains are realized. NFV service chains are synthesized while eliminating redundant input/output and repeated elements, providing consolidated stateful cross layer packet operations across the chain. This software-based synthesis achieves line-rate 40 Gbps throughput for stateful and long service chains. This performance is 8.5x higher than the performance achieved by the software-based state of the art FastClick framework. Experiments with three example Internet Service Provider-level service chains show that this synthesis approach operates at 40 Gbps, when the classification of these chains is offloaded to an OpenFlow switch.
Nätverksfunktioner (NF) har en nyckelroll i nätverk. De erbjuder tjänster i nätverken som förbättrad prestanda, policy övervakning och säkerhetsfunktioner. Vanligtvis så har NF implementerats med hjälp av specialiserad, och därmed kostsam, hårdvara. Detta har lett till att nätverksoperatörer har börjat använda nätverksfunktionsvirtualisering (NFV) för att minska kostnaden. NFV implementeras genom att NF flyttas från specialiserad hårdvara till mjukvara som kör på vanliga servrar. Flera försök med NFV har visat att vanliga nätverksstackar och drivrutiner (exempelvis Linux baserade) har svårt att erbjuda samma prestanda som hårdvaran gör. Trots detta bygger flera populära nätverkstjänster på NFV. Dessutom är det en utmaning att koppla samman NFV i kedjor, då redundanta operationer utförs. I den här avhandlingen försöker vi lösa prestanda problem kopplade till kedjor av NFV. Det första bidraget i den här avhandlingen är ett ramverk som (i) profilerar NFV kedjor för att hitta orsaker till prestanda problem samt (ii) använder profileringsdata för att förbättra prestandan i kedjorna. Detta görs genom att kombinera multiplexing av systemanrop med planläggningsstrategier. Tillsammans förbättrar dessa lösningar cache användningen och minskar därmed end-to-end latensen i kedjade NFV med en faktor tre. Dessutom minskar vår metod variansen i latens, något som är viktigt för tjänstekvalitén i interaktiva tjänster.Det andra bidraget i den här avhandlingen är en omarbetning av hur kedjade NFV konstrueras. Vi syntetiserar NFV service kedjor genom att ta bort redundanta element och konsoliderar paketoperationer som sträcker sig över flera lager i nätverksstacken. Vår mjukvarubaserade lösning klarar av 40 Gbps genomströmning i en lång kedja. Detta är 8.5 ggr mer än vad som uppnåtts med den tidigare standard lösningen för mjukvara, ramverket FastClick. Vi presenterar experiment med tre servicekedjor för nätverksleverantörer där vår syntetiserade lösning klarar 40 Gbps, när klassificeringen av kedjan görs med hjälp av en OpenFlow switch.

QC 20161103

European Union Horizon 2020 BEhavioural BAsed forwarding (BEBA)
European Research Council (ERC) PROPHET

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Książki na temat "Gbp2"

Yong, Su-Khiong SK, Pengfei Xia i Alberto Valdes-Garcia, red. 60 GHz Technology for Gbps WLAN and WPAN. Chichester, UK: John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470972946.

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Bangsa, Partai Kebangkitan. GBPP: Garis-garis besar program perjuangan Partai Kebangkitan Bangsa. Jakarta: Dewan Pengurus Pusat, Partai Kebangkitan Bangsa, 2000.

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Agama, Indonesia Departemen, red. Kurikulum madrasah aliyah: Garis-garis besar program pengajaran (GBPP). Jakarta: Departemen Agama, Republik Indonesia, 1993.

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Iskandar, Dodi R. Pegangan sejarah nasional Indonesia dan dunia: Kurikulum 1984/GBPP 1987. Bandung: Armico, 1987.

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Peng, Li Mike, red. Design and test for multiple GBPS communication devices and systems. Chicago, Ill: International Engineering Consortium, 2005.

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Indonesia. Departemen Pendidikan dan Kebudayaan., red. Kurikulum sekolah dasar (SD): Garis-garis besar program pengajaran (GBPP). [Jakarta]: Departemen Pendidikan dan Kebudayaan, 1990.

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Kansil, C. S. T. Pendidikan sejarah perjuangan bangsa: Kurikulum 1984, GBPP 1987, pola pendekatan CBSA. Jakarta: Erlangga, 1991.

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International Business Machines Corporation. International Technical Support Organization, red. IBM b-type Gen 5 16 gbps switches and network advisor. Poughkeepsie, NY: IBM Corp., International Technical Support Organization, 2014.

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International Business Machines Corporation. International Technical Support Organization, red. Implementing an IBM/Brocade SAN with 8 Gbps directors and switches. Wyd. 9. [Poughkeepsi, NY?]: International Business Machines Corp., 2009.

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International Business Machines Corporation. International Technical Support Organization, red. Implementing an IBM/Brocade SAN with 8 Gbps directors and switches. [Poughkeepsi, NY?]: International Business Machines Corp., 2009.

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Części książek na temat "Gbp2"

Sundberg, Simon, Anna Brunstrom, Simone Ferlin-Reiter, Toke Høiland-Jørgensen i Jesper Dangaard Brouer. "Efficient Continuous Latency Monitoring with eBPF". W Passive and Active Measurement, 191–208. Cham: Springer Nature Switzerland, 2023. http://dx.doi.org/10.1007/978-3-031-28486-1_9.

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AbstractNetwork latency is a critical factor for the perceived quality of experience for many applications. With an increasing focus on interactive and real-time applications, which require reliable and low latency, the ability to continuously and efficiently monitor latency is becoming more important than ever. Always-on passive monitoring of latency can provide continuous latency metrics without injecting any traffic into the network. However, software-based monitoring tools often struggle to keep up with traffic as packet rates increase, especially on contemporary multi-Gbps interfaces. We investigate the feasibility of using eBPF to enable efficient passive network latency monitoring by implementing an evolved Passive Ping (ePPing). Our evaluation shows that ePPing delivers accurate RTT measurements and can handle over 1 Mpps, or correspondingly over 10 Gbps, on a single core, greatly improving on state-of-the-art software based solutions, such as PPing.

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Wolf, Mike, Jianhui Li, Liane Grobe, Dominic O’Brien, Hoa Le Minh i Olivier Bouchet. "Challenges in Gbps Wireless Optical Transmission". W Lecture Notes of the Institute for Computer Sciences, Social Informatics and Telecommunications Engineering, 484–95. Berlin, Heidelberg: Springer Berlin Heidelberg, 2010. http://dx.doi.org/10.1007/978-3-642-16644-0_42.

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Yokoyama, H., Y. Nambu i T. Shimizu. "100-Gbps Response of Microcavity Lasers". W Ultrafast Phenomena VIII, 220–21. Berlin, Heidelberg: Springer Berlin Heidelberg, 1993. http://dx.doi.org/10.1007/978-3-642-84910-7_64.

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Gupta, S. C. "100 Gbps High-Speed Broadband Networks". W Advances in Intelligent Systems and Computing, 1–7. Singapore: Springer Singapore, 2017. http://dx.doi.org/10.1007/978-981-10-6005-2_1.

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de Carvalho, J. A. R. Pacheco, N. Marques, H. Veiga, C. F. Ribeiro Pacheco i A. D. Reis. "A Medium Range Gbps FSO Link". W Electrical Engineering and Applied Computing, 125–33. Dordrecht: Springer Netherlands, 2011. http://dx.doi.org/10.1007/978-94-007-1192-1_11.

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Alexander, Khary, Ramesh Karri, Igor Minkin, Kaijie Wu, Piyush Mishra i Xuan Li. "Towards 10-100 Gbps Cryptographic Architectures1". W Proceedings of The 17th International Symposium on Computer and Information Sciences, 25–30. Boca Raton: CRC Press, 2022. http://dx.doi.org/10.1201/9780429332821-7.

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Yong, Su-khiong sk. "Introduction to 60GHz". W 60 GHz Technology for Gbps WLAN and WPAN, 1–16. Chichester, UK: John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470972946.ch1.

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Valdes-Garcia, Alberto, Pengfei Xia, Su-Khiong Yong i Harkirat Singh. "Remaining Challenges and Future Directions". W 60 GHz Technology for Gbps WLAN and WPAN, 267–71. Chichester, UK: John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470972946.ch10.

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Yong, Su-khiong sk. "60GHz Channel Characterizations and Modeling". W 60 GHz Technology for Gbps WLAN and WPAN, 17–61. Chichester, UK: John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470972946.ch2.

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Choi, Chang-Soon, Maxim Piz i Eckhard Grass. "Non-Ideal Radio Frequency Front-End Models in 60GHz Systems". W 60 GHz Technology for Gbps WLAN and WPAN, 63–87. Chichester, UK: John Wiley & Sons, Ltd, 2010. http://dx.doi.org/10.1002/9780470972946.ch3.

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Streszczenia konferencji na temat "Gbp2"

Wenhui, H., H. wenhui i M. Ying. "Exosomes Containing GBP2 in Macrophage Induced by Lipopolysaccharide Activate NLRP3 Inflammasome to Mediate the Pyroptosis of Alveolar Type II Cell: A New Mechanism of ALI". W American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA. American Thoracic Society, 2020. http://dx.doi.org/10.1164/ajrccm-conference.2020.201.1_meetingabstracts.a5563.

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Naoe, Kazuhiko. "Ultrahigh Speed EA-DFB Lasers beyond 200 Gbps per Lane". W Optical Fiber Communication Conference. Washington, D.C.: Optica Publishing Group, 2023. http://dx.doi.org/10.1364/ofc.2023.m2d.1.

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We describe 224 Gbps-PAM4 uncooled operation by EA-DFB. Moreover, 330.8-Gbps PAM6 (128-Gbaud PAM6), 384 Gbps PAM8 (128-Gbaud PAM8) and 420 Gbps PAM8 (140-Gbaud PAM8) operations by ultrahigh speed EA-DFB are reviewed.

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Wei, Zixian, Jinsong Zhang, Weijia Li i David V. Plant. "TDMA Frame Design and Demonstration of Encrypted Coherent Fronthaul with Flexible and Monitored Rate". W CLEO: Science and Innovations. Washington, D.C.: Optica Publishing Group, 2023. http://dx.doi.org/10.1364/cleo_si.2023.sf2m.4.

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We introduce a TDMA frame design scheme considering the flexible rate and physical layer security. A 225.39-Gbps to 281.62-Gbps net rate tuning with a step of 3.124 Gbps/pol./λ is achieved on a coherent optical transmission system.

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Kishi, Toshiki, Munehiko Nagatani, Shigeru Kanazawa, Kota Shikama, Takuro Fujii, Hidetaka Nishi, Tadashi Minotani, Norio Sato, Toru Segawa i Shinji Matsuo. "30-Gbps/ch x 4 ch Simultaneous Error-Free Transmission with A Low-Power Transmitter Flip-Chip-Bonded 1.3-µm LD-Array-on-Si". W Optical Fiber Communication Conference. Washington, D.C.: Optica Publishing Group, 2023. http://dx.doi.org/10.1364/ofc.2023.m4e.2.

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30-Gbps/ch NRZ PRBS-31 x 4 ch simultaneous error-free 1.6-km transmission was achieved with a low-power 4-ch transmitter consisting of 65-nm CMOS cascode shunt LD drivers and flip-chip-bonded LD-array-on-Si, resulting in power efficiency of 1.2 mW/Gbps.

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Yuan, Yuan, Yiwei Peng, Zhihong Huang, Jared Hulme, Stanley Cheung, Wayne V. Sorin, Di Liang, Marco Fiorentino i Raymond G. Beausoleil. "A 4 × 100 Gbps DWDM Receiver using All-Si Microring Avalanche Photodiodes". W Optical Fiber Communication Conference. Washington, D.C.: Optica Publishing Group, 2023. http://dx.doi.org/10.1364/ofc.2023.w1a.5.

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We demonstrate an O-band 4-channel DWDM receiver using all-Si microring APDs. Each all-Si APD exhibits a low dark current at nA level before the breakdown, a responsivity of ~ 0.5 A/W, and a 3-dB bandwidth of ~ 44 GHz. All 4 channels are capable of open eye diagrams at 50 Gbps NRZ and 100 Gbps PAM4 operations.

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Logan, Ronald T., Sean Zargari, Einar Chua, Arturo Chua, Rolf Wyss, Justin J. Schaefer, Ian A. Troxel i Matthew Gruber. "Radiation Test Results for Glenair 5 Gbps and 40 Gbps (4x10 Gbps) Optical Transceivers". W 2019 IEEE Radiation Effects Data Workshop (IEEE) (in conjunction with NSREC 2019). IEEE, 2019. http://dx.doi.org/10.1109/redw.2019.8906588.

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Maliszewski, Anderson, Eduardo Roloff, Dalvan Griebler i Philippe Olivier Navaux. "O Impacto da Interconexão de Rede no Desempenho de Programas Paralelos". W XX Simpósio em Sistemas Computacionais de Alto Desempenho. Sociedade Brasileira de Computação, 2019. http://dx.doi.org/10.5753/wscad.2019.8658.

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O desempenho de aplicações paralelas depende de dois componentes principais do ambiente; o poder de processamento e a interconexão de rede. Neste trabalho, foi avaliado o impacto de uma interconexão de alto desempenho em programas paralelos em um cluster homogêneo de servidores interconectados por Gigabit Ethernet 1 Gbps e InfiniBand FDR 56 Gbps. Foi realizada uma caracterização do NAS Parallel Benchmarks em relação à computação, comunicação e custo de execução em instâncias da Microsoft Azure. Os resultados mostraram que, em aplicações altamente dependentes de rede, o desempenho pode ser significativamente melhorado ao utilizar InfiniBand a um custo de execução melhor, mesmo com o preço superior da instância.

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Tsang, Dean Z. "High-Density 300-Gbps/cm2 Parallel Free-Space Optical Interconnection Design Considerations". W Optical Computing. Washington, D.C.: Optica Publishing Group, 1995. http://dx.doi.org/10.1364/optcomp.1995.othb2.

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A high-density, high-throughput 300-Gbps/cm2 parallel free-space optical interconnection has been designed and demonstrated. The impact of component technology choices and optical, electrical, and mechanical issues will be discussed within the context of this prototype system with implications for future systems. Many of the design considerations for this prototype are common to other optical interconnection and processing systems based on arrays of components. The prototype, a linear array parallel free-space optical interconnection with up to twenty optical data paths, operated at a rate of up to 2.8 Gbps per optical data path with a delay or latency of 200 ps.

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Ponchet, A. F., E. M. Bastida, R. R. Panepucci i J. W. Swart. "Low noise Si based monolithic transimpedance amplifiers for 10 Gbps, 40 Gbps and 100 Gbps applications". W 2014 International Caribbean Conference on Devices, Circuits and Systems (ICCDCS). IEEE, 2014. http://dx.doi.org/10.1109/iccdcs.2014.7016156.

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Rajan, Alpana, i Brijendra Kumar Joshi. "Performance comparison of 20 Gbps and 40 Gbps InfiniBand interconnect". W 2014 International Conference on Computing for Sustainable Global Development (INDIACom). IEEE, 2014. http://dx.doi.org/10.1109/indiacom.2014.6828138.

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Raporty organizacyjne na temat "Gbp2"

Chakraborty, Sanchita, Vignesh Mariappan, Shalinda Adikari, Lokesh Shanmugam, Joshy M. Easow i Agieshkumar Balakrishna Pillai. Differential expression of interferon inducible protein: guanylate binding protein (GBP1 & GBP2) in severe dengue. Peeref, czerwiec 2023. http://dx.doi.org/10.54985/peeref.2306p1644622.

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Kuznia, Charlie. Embedded 100 Gbps Photonic Components. Office of Scientific and Technical Information (OSTI), kwiecień 2018. http://dx.doi.org/10.2172/1434711.

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Bischof, Jannis, Philipp Dörrenberg, Davud Rostam-Afschar, Dirk Simons i Johannes Voget. GBP-Monitor: Unternehmenstrends im Oktober 2021. TRR 266 Accounting for Transparency, 2021. http://dx.doi.org/10.52569/zcya6673.

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Bischof, Jannis, Philipp Dörrenberg, Davud Rostam-Afschar, Dirk Simons i Johannes Voget. GBP-Monitor: Unternehmenstrends im September 2021. TRR 266 Accounting for Transparency, 2021. http://dx.doi.org/10.52569/qrpq4370.

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Bischof, Jannis, Philip Dörrenberg, Davud Rostam-Afschar, Dirk Simons i Johannes Voget. GBP-Monitor: Unternehmenstrends im November 2021. TRR 266 Accounting for Transparency, listopad 2021. http://dx.doi.org/10.52569/krax2859.

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Bischof, Jannis, Philipp Dörrenberg, Davud Rostam-Afschar, Dirk Simons i Johannes Voget. GBP-Monitor: Unternehmenstrends im Januar 2021. TRR 266 Accounting for Transparency, 2022. http://dx.doi.org/10.52569/jrkm2116.

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Bischof, Jannis, Philipp Dörrenberg, Davud Rostam-Afschar, Dirk Simons i Johannes Voget. GBP-Monitor: Unternehmenstrends im März 2022. TRR 266 Accounting for Transparency, marzec 2022. http://dx.doi.org/10.52569/esos1377.

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Bischof, Jannis, Philipp Dörrenberg, Davud Rostam-Afschar, Dirk Simons i Johannes Voget. GBP-Monitor: Unternehmenstrends im April 2022. TRR 266 Accounting for Transparency, kwiecień 2022. http://dx.doi.org/10.52569/dtwt9240.

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Bischof, Jannis, Philipp Dörrenberg, Davud Rostam-Afschar, Dirk Simons i Johannes Voget. GBP-Monitor: Unternehmenstrends im Mai 2022. TRR 266 Accounting for Transparency, maj 2022. http://dx.doi.org/10.52569/marv8105.

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Bischof, Jannis, Philipp Dörrenberg, Davud Rostam-Afschar, Dirk Simons i Johannes Voget. GBP-Monitor Unternehmenstrends im Juni 2022. TRR 266 Accounting for Transparency, 2022. http://dx.doi.org/10.52569/clrj1409.

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