Gotowa bibliografia na temat „G-908”

ABSTRACT Live oral Ty21a and parenteral Vi polysaccharide vaccines provide significant protection against typhoid fever, albeit by distinct immune mechanisms. Vi stimulates serum immunoglobulin G Vi antibodies, whereas Ty21a, which does not express Vi, elicits humoral and cell-mediated immune responses other than Vi antibodies. Protection may be enhanced if serum Vi antibody as well as cell-mediated and humoral responses can be stimulated. Disappointingly, several new attenuated Salmonella enterica serovar Typhi oral vaccines (e.g., CVD 908-htrA and Ty800) that elicit serum O and H antibody and cell-mediated responses following a single dose do not stimulate serum Vi antibody. Vi expression is regulated in response to environmental signals such as osmolarity by controlling the transcription oftviA in the viaB locus. To investigate if Vi antibodies can be stimulated if Vi expression is rendered constitutive, we replaced P tviA in serovar Typhi vaccine CVD 908-htrA with the constitutive promoter P tac , resulting in CVD 909. CVD 909 expresses Vi even under high-osmolarity conditions and is less invasive for Henle 407 cells. In mice immunized with a single intranasal dose, CVD 909 was more immunogenic than CVD 908-htrA in eliciting serum Vi antibodies (geometric mean titer of 160 versus 49, P = 0.0007), whereas O antibody responses were virtually identical (geometric mean titer of 87 versus 80). In mice challenged intraperitoneally with wild-type serovar Typhi 4 weeks after a single intranasal immunization, the mortality of those immunized with CVD 909 (3 of 8) was significantly lower than that of control mice (10 of 10,P = 0.043) or mice given CVD 908-htrA (9 of 10, P = 0.0065).

This study investigated the single nucleotide polymorphisms (SNPs) of Fatty acid desaturase 2 (FADS2) gene and further explored their genetic effects on conventionally collected milk production traits in Chinese Holstein cows using 18,264 test-day records of 841 cows. One missense mutation c. 908 C > T (SNP site in the complementary DNA sequence), which caused an amino acid change from alanine to valine (294Ala > Val), and two 3’ untranslated region (UTR) SNPs, c.1571 G > A and c.2776 A > G were finally identified. The SNP c.908 C > T was significantly associated with test-day milk yield, fat percentage and 305-day milk, fat and protein yield. In particular, the T allele of the SNP c.908 C > T showed a significant association with decreased somatic cell score (SCS) in the investigated population. Significant relationship between the SNP c.1571 G > A and 305-day milk yield showed that genotype GG was linked to the highest milk yield. Substituting the allele G for A at the c.2776 A > G locus resulted in a decrease of protein percentage. Our results demonstrated that FADS2 was an interesting candidate for selection to increase milk production and improve resistance against mastitis.

A H-transfer process for oligomerized imide and thioimide is proposed offering ultra-high theoretical capacities of 1246 and 908 mA h g−1 and practical capacities of 464.6 and 820.6 mA h g−1. This work provides a new energy storage mechanism for organic electrode materials.

ABSTRACTLive attenuated bacterial strains expressing heterologous antigens represent an attractive vaccine development strategy. However, the use of drug resistance genes for the selection of expression plasmids introduced into live vectors poses theoretical health risks. Therefore, we developed a novel approach for plasmid selection based on immunity to the antimicrobial peptide microcin H47 (MccH47). Two expression plasmids encoding the reporter green fluorescent protein (GFPuv) were constructed; selection markers comprised eithermchI, conferring immunity to MccH47 (pGEN222I), orbla(encoding β-lactamase), conferring conventional resistance to ampicillin (pGEN222). GFPuv-specific serum immunoglobulin G (IgG) antibody responses were analyzed in mice immunized intranasally either withSalmonella entericaserovar Typhi CVD 908-htrAorShigella flexneri2a CVD 1208S live vector and were boosted parenterally with purified GFPuv. Similar IgG antibody responses were observed for both pGEN222 and pGEN222I when either CVD 1208S or CVD 908-htrA(pGEN222I) was used as the carrier. Interestingly, CVD 908-htrA(pGEN222I) elicited a significantly higher IgG response than CVD 908-htrA(pGEN222). We also compared the priming potential of homologous priming either with CVD 908-htrA(pGEN222I) or CVD 1208S(pGEN222I) to heterologous priming first with CVD 908-htrA(pGEN222I) and then with CVD 1208S(pGEN222I) and vice versa. Immunization with two unrelated live vectors significantly enhanced the IgG responses compared to responses engendered by homologous CVD 908-htrA(pGEN222I) but not to those of CVD 1208S(pGEN222I). MccH47 offers an alternate system for plasmid selection in bacterial live vectors that greatly improves their clinical acceptability. Furthermore, the success of the heterologous priming strategy supports the feasibility of the future development of multivalent live vector-based immunization strategies against multiple human pathogens.

Schriftkundliche Untersuchungen haben zur Klärung verschiedener Fragen geführt. J. L. Krebs kann als Komponist der BWV 567 und BWV Anh. 27 identifiziert werden. Wahrscheinlich haben folgende Komponisten die mit ihrem jeweiligen Namen aufgeführten und bisher zu Unrecht Bach zugeschriebenen Werke geschrieben: C. P. E. Bach (BWV 1020), J. E. Bach (Bach-Inc. 47), G. Kirchhoff (BWV 907, 908), B. Pasquini (BWV 833). BWV 525 existiert wahrscheinlich in einer früheren B-Dur Version. Neben einigen weiteren Schriftidentifikationen aus dem Kreis der Bachschüler kann nachgewiesen werden, dass Bach Werke von F. Conti, B. Pasquini und D. Buxtehude aufgeführt hat. (Übertragung des englischen Resümees am Ende des Bandes)

We studied the effect of the organic chicken manure on the growth and development of cocoa trees (Theobroma cacao L.), during their juvenile stage. The experiment was initiated in February, 1993, in three commercial plantations, 20 months old, located in the county of El Rama, Region V. During the following 14 months we carried out three application , comparing, the three levels of chicken manure (454 , 908 . and 1,362 g per tree and application) with mineral fertilizer (three applications , of 15-15-15fertilizers100 g per tree, plus one application of, urea 100 g per tree), and a check without any applications. A random complete bolck design was utilized and means were compared by, Duncan’s test and regression and correlation analyses were also made. The results showed that with the application of 1,362 g of chicken manure, a significatively higher effect over the initial production of cocoa, and an increase of the stalk diameter were observed. The applications of 454 and 908, of chicken manure resulted in production levels equal to those of the treatment with mineral fertilizers. In relation to plant height, we did not find statistical differences among treatments. The treatment without fertilizer , showed the smallest growth and lower production.

The reactivity of single-stranded thymidines with osmium tetraoxide was used to demonstrate the existence of a terminal overhang of the G-rich strand of telomeres from two distantly related eucaryotes, the ciliated protozoan Tetrahymena spp. and the acellular slime mold Didymium spp. Conservation of a G-strand overhang at the molecular terminus of telomeres is consistent with our suggestion that an unusual DNA structure formed by the G-strand overhang is important for telomere function (E. Henderson, C. C. Hardin, S. K. Wolk, I. Tinoco Jr., and E. H. Blackburn, Cell 51:899-908, 1987).

The reactivity of single-stranded thymidines with osmium tetraoxide was used to demonstrate the existence of a terminal overhang of the G-rich strand of telomeres from two distantly related eucaryotes, the ciliated protozoan Tetrahymena spp. and the acellular slime mold Didymium spp. Conservation of a G-strand overhang at the molecular terminus of telomeres is consistent with our suggestion that an unusual DNA structure formed by the G-strand overhang is important for telomere function (E. Henderson, C. C. Hardin, S. K. Wolk, I. Tinoco Jr., and E. H. Blackburn, Cell 51:899-908, 1987).

Abstract The paper aimed at the experimental manufacture of a foam glass gravel type by sintering at over 900 ºC a powder mixture composed of recycled glass waste (92%), sodium borate (6%), kaolin (0.3%), silicon carbide (1.7%) and water addition (12%). The originality of the work was the application of the unconventional technique of microwave heating through a predominantly direct heating procedure. The product foamed at 908 ºC had a very fine porous structure (pore size between 0.05-0.20 mm) and a compressive strength above the usual level of foam glass gravels (7.8 MPa). The apparent density of 0.28 g/cm3 corresponding to a bulk density of 0.20 g/cm3 and the thermal conductivity of 0.075 W/m·K ensures the thermal insulating character of the material required for use in the specific field of applications of foam glass gravel. The manufacturing process had an excellent energy efficiency, the specific energy consumption decreasing up to 0.70 kWh/kg.

Abstract This study evaluated the effect of replacing soybean meal (SBM) with DDGS and crystalline amino acids on growth and carcass lean. Pigs (n = 512; 38.51±0.13 kg BW) were blocked by BW and sex and placed in 64 pens (4 gilts and barrows per pen). Treatments were arranged as a 2×4 factorial with DDGS included at 0 or 25% and L-lysine-HCl (LYS) added at 0, 0.2, 0.4, and 0.6%. Dietary SBM inclusion declined as LYS increased from 32.06 to 13.14% (Phase 1) and 28.25 to 9.40% (Phase 2) for control diets. It declined from 27.85 to 8.89% (Phase 1) and 24.05 to 5.10% (Phase 2) for DDGS diets. Diets contained 1.00 (Phase 1, 21 days) and 0.90% (Phase 2, 18 days) SID lysine and were balanced for ideal protein and net energy. During Phase 1, DDGS decreased ADG (P = 0.06; 786 vs. 821 g/d). Increasing LYS increased (quadratic, P ≤ 0.05) ADG and ADFI with the greatest response at 0.4% LYS. G:F decreased (linear, P = 0.035) with increasing LYS. During Phase 2, increasing LYS in control, but not DDGS diets, decreased (linear, P < 0.005) ADG and ADFI. G:F declined (P = 0.054) with DDGS inclusion (370 vs. 383 g/kg). Overall, ADG decreased (linear, P = 0.005) as LYS increased in control (959, 929, 908, 860 g/d), but not DDGS diets (863, 908, 931, 832 g/d). ADFI decreased (linear, P = 0.014) with increasing LYS in control (2270, 2198, 2186, 2130 g/d), but increased (quadratic, P = 0.039) in DDGS diets (2112, 2207, 2324, 2103 g/d). DDGS reduced (P≤0.03) ADG (883 vs. 914 g/d), G:F (405 vs. 417 g/kg) and LEA (34.5 vs. 35.3 cm2), while increasing LYS decreased (linear, P < 0.005) G:F (417, 419, 409, 401 g/kg) and LEA (35.34, 35.17, 35.46, 33.64 cm2). Displacement of SBM with DDGS reduced growth and LYS addition negatively affected growth and G:F for diets with SBM, but not DDGS.

Submitted by SBI Biblioteca Digital (sbi.bibliotecadigital@puc-campinas.edu.br) on 2017-02-15T12:32:08Z No. of bitstreams: 1 DANIELA VICINANSA MONACO FERREIRA.pdf: 2575283 bytes, checksum: e154c9b7ae508a96205c1d597a55aee6 (MD5)
Made available in DSpace on 2017-02-15T12:32:08Z (GMT). No. of bitstreams: 1 DANIELA VICINANSA MONACO FERREIRA.pdf: 2575283 bytes, checksum: e154c9b7ae508a96205c1d597a55aee6 (MD5) Previous issue date: 2016-12-01
Coordena??o de Aperfei?oamento de Pessoal de N?vel Superior - CAPES
Morbid obesity, a chronic and multifactorial disease, causes metabolic disorders and increases the risk of morbidity. Its prevalence has been increasing, with alarming data in Brazil and elsewhere. Globally, Brazil ranks second in number of bariatric surgeries, but surgical treatment is a challenge for the patients and the teams that provide care for these patients. Given the above, the present study aimed to assess changes in nutritional status and identify nutritional deficiencies before and 10 years after Roux-en-Y gastric bypass. This retrospective study lasted two years and included 166 patients submitted to Roux-en-Y gastric bypass at a private clinic. The statistical analyses included the chi-square, Fisher?s, Mann-Whitney, and Wilcoxon tests, analysis of variance (ANOVA), and generalized estimating equations. The significance level was set at 5%. At the ten-year follow-up, the percentage of excess weight loss (%EWL), body mass index (BMI), and weight regain were 51.64?18.03 (p<0.0001), 32.53?4.83 kg/m2 (p<0.0001), and 41% (p<0.0001), respectively, and the lipid and blood glucose profiles had improved (p<0.0001). Iron-deficiency anemia was found in 37.5% and 45.0% of the patients who attended the 10-year follow-up based on ferritin levels <15 ug/L and <30 ug/L, respectively. The effect of time was significant for hemoglobin, ferritin, iron overload (p<0.0001), and hematocrit (p=0.0007). Vitamin D deficiency was found in 29 patients (82.86%), and high parathormone (PTH), in 13 (41.94%). The effect of time was significant for PTH (p=0.0059). In conclusion, gastric bypass was a surgical success and improved the metabolic profile. Weight regain increased over time. The nutritional outcomes were iron-deficiency anemia and vitamin D deficiency associated with secondary hyperparathyroidism. These findings reaffirm the importance of multidisciplinary care and monitoring of nutritional deficiencies for the treatment of morbid obesity.
A obesidade m?rbida considerada uma doen?a cr?nica e multifatorial, que ocasiona desordens metab?licas e aumenta o risco de morbidade, vem crescendo, com dados alarmantes no Brasil e no Mundo. O Brasil ? o segundo Pa?s que mais realiza cirurgia bari?trica, sendo o tratamento cir?rgico, um desafio para os pacientes e para as equipes envolvidas no cuidado destes pacientes. Diante do exposto, o presente trabalho teve como objetivo avaliar a evolu??o do estado nutricional e identificar as defici?ncias nutricionais no pr? e no p?s-operat?rio de pacientes submetidos ao bypass g?strico em Y-de-Roux, com 10 anos de seguimento. O estudo realizado em dois anos, com delineamento retrospectivo longitudinal, envolveu 166 pacientes submetidos ao bypass g?strico em Y-de-Roux, em uma cl?nica privada. Na an?lise estat?stica, utilizou-se os testes Qui-Quadrado, Fisher, Mann-Whitney, Anova, Wilcoxon e Equa??es de Estimativas Generalizadas. O n?vel de signific?ncia adotado foi de 5%. Os resultados deste estudo, ap?s 10 anos de seguimento, demostraram percentual de perda do excesso de peso (%PEP) de 51,64?18,03 (p<0,0001); Indice de Massa Corporal (IMC) de 32,53?4,83 kg/m2 (p<0,0001); reganho de peso de 41% (p<0,0001). O perfil lip?dico e glic?mico diminuiu ao longo de 10 anos de seguimento (p<0,0001). Dos pacientes que permaneceram no estudo at? o final de 120 meses, 37,5% e 45,0%, apresentaram diagn?stico de anemia ferropriva, considerando-se os crit?rios utilizados de ferritina <15 ug/L e ferritina <30 ug/L, respectivamente. O efeito do tempo foi significativo para a hemoglobina, ferritina e sobrecarga de ferro, (p<0,0001) e hemat?crito (p=0,0007). Em rela??o ao metabolismo do c?lcio, 82,86% (29), apresentaram n?veis de defici?ncia de vitamina D e 41,94% (13) apresentaram PTH elevado. O efeito do tempo foi significativo para o PTH (p=0,0059). Em conclus?o, pacientes submetidos ao bypass g?strico, apresentaram sucesso cir?rgico e melhora do perfil metab?lico. O reganho de peso aumentou com o tempo de seguimento. A anemia ferropriva e a defici?ncia de vitamina D, associada ao hiperparatireoidismo secund?rio, foram desfechos nutricionais encontrados Tais achados reafirmam a import?ncia do cuidado multidisciplinar e ? aten??o ?s defici?ncias nutricionais para o tratamento da obesidade m?rbida.

Made available in DSpace on 2015-04-14T13:22:31Z (GMT). No. of bitstreams: 1 465805.pdf: 388574 bytes, checksum: 9850bdab8a5139b1add07d2f62d993b2 (MD5) Previous issue date: 2015-01-08
The main objective of this dissertation is to understand, from the point of view of women, the meaning of having a loving relationship and conceiving a child from an incarcerated man. We carried out semi-structured interviews at the prison called Pres?dio Central de Porto Alegre (PCPA) with women who have children with incarcerated partners in that prison. To analyze the data we used Critical Discourse Analysis (CDA). This kind of discursive investigation focuses especially on social problems, explaining them by means of structure and social interaction. The dissertation is composed of two articles, both arising from empirical studies. In the first study, based on interviews with three women whose partners are serving time at PCPA, we sought to understand their motivations for maintaining this relationship, as well as to know the roles played and the violence they notice in prison. The analyzed data confirm the social expectation that women care for their partners. The sacrifice arising from the non-abandonment is followed by the desire to be rewarded by their partners after the latter's serving time. The submission of these women, who perceive themselves obliged to maintain their relationships, to visit, to provide their partners materially and emotionally and to endure the violence imposed by the prison is resignified from the leadership they assume. This role is expressed through their power of decision to go to the prison, take their children to the visits and provide inputs to their partners. The second article consists of interviews with two women whose lives are marked by great familiarity with prison and who became pregnant at PCPA when visiting their partners. In this study we sought to understand what meanings they attribute to conceiving their children in prison. Therefore, we investigated the participants' conceptions of maternity, paternity and family. In the analyzed data we see the appropriation of hegemonic models of maternity and paternity based on the ideal of a nuclear family. On the other hand, the non-normative character of their life stories marked by familiarity with the prison outlines other possible discourses that question this hegemonic model. Thus, we can see in the discourse of the participants several and contradictory references in their attempts to build places of mothers and fathers. Such a contradiction resulting from simultaneous movements of appropriation and resistance to normative discourses draws our attention to the dialectical process of subjective construction. In other words, these women signify parental roles from family/community and social/cultural references.
A presente disserta??o tem como objetivo geral compreender, do ponto de vista das mulheres, os significados de ter um relacionamento afetivo e de conceber um filho com um homem encarcerado. Foram realizadas entrevistas semiestruturadas no Pres?dio Central de Porto Alegre (PCPA) com mulheres que t?m filhos com parceiros encarcerados nesta pris?o. Para a an?lise dos dados coletados foi usada a abordagem da An?lise Cr?tica do Discurso (ACD). Este tipo de investiga??o discursiva concentra-se, em especial, nos problemas sociais, explicando-os por meio da estrutura e intera??o social. A disserta??o ? composta por dois artigos, ambos resultantes de estudos emp?ricos. No primeiro estudo, a partir de entrevistas com tr?s mulheres cujos companheiros cumprem pena no PCPA, buscamos compreender as suas motiva??es para manter este relacionamento, bem como conhecer os pap?is desempenhados e as viol?ncias percebidas por elas na pris?o. Os dados analisados atestam a expectativa social de que as mulheres exer?am o cuidado de seus parceiros. O sacrif?cio advindo do n?o-abandono ? acompanhado pelo desejo de serem recompensadas pelos companheiros ap?s o per?odo de cumprimento de suas penas. A submiss?o destas mulheres, que se percebem obrigadas a manter seus relacionamentos, a visitar, a prover seus companheiros material e emocionalmente e a suportar as viol?ncias impostas pela pris?o, ? ressignificada a partir do protagonismo expresso por elas. Tal protagonismo se expressa atrav?s do poder de decis?o das entrevistadas de ir ? pris?o, de levar seus filhos ?s visitas e de fornecer insumos aos seus companheiros. O segundo artigo ? composto por entrevistas com duas mulheres que possuem trajet?rias marcadas pela grande familiaridade com a pris?o e que engravidaram no PCPA em dias de visita a seus parceiros. Neste estudo procuramos compreender quais s?o os significados atribu?dos por elas ? concep??o de um filho dentro do c?rcere. Neste sentido, investigamos as concep??es de maternidade, de paternidade e de fam?lia das participantes. Na an?lise dos dados vemos a apropria??o de modelos hegem?nicos de maternidade e paternidade, fundamentados no ideal da fam?lia nuclear. Por outro lado, a n?o normatividade de suas hist?rias de vida marcadas pela familiaridade com a pris?o delineia outras possibilidades de discurso que colocam em xeque este modelo hegem?nico. Desse modo, convivem no discurso das participantes refer?ncias diversas e contradit?rias em suas tentativas de construir os lugares de pais e m?es. Tal contradi??o, resultante de simult?neos movimentos de apropria??o e resist?ncia a discursos normativos, nos chama a aten??o para o processo dial?tico de constru??o subjetiva. Em outras palavras, ? a partir de referenciais familiares/comunit?rios e sociais/culturais que estas mulheres significam as fun??es paternas e maternas.

Alek Fraser spent most of his adult life in the world of education in the British colonies. His tenure of office as Principal of Trinity College, Kandy, one of Ceylon's most prestigious schools for boys, ran from 1904 to 1924 and covered a period of immense educational, societal and political change. Fraser's own vision of his task was to create an environment in which indigenous Christianity would develop within the island. For Fraser the whole future of the colony depended upon the success of this venture, the creation of a truly Eastern nation rooted in an indigenous leadership committed to Christianity.

Ida v. Lüttichau hatte eine sehr eigene und kaum eindeutig zu bestimmende Bedeutung in den literarischen und musikalischen Kreisen Dresdens. Bekanntgeworden ist ihr Austausch mit dem Naturforscher, Arzt und Maler C. G. Carus, dem Dichter Ludwig Tieck und mit Richard Wagner. Diese Dokumentation sammelt nahezu sämtliche zu früheren Zeiten an unterschiedlichen Stellen veröffentlichten Aufzeichnungen und Briefe von Ida sowie Erinnerungen an sie. Einige Originaldokumente/Autographen Ida v. Lüttichaus erscheinen hier erstmalig. - Ergänzt wird dies durch Exzerpte aus zumeist zeitgenössischen Büchern, die etwas von der kulturellen und politischen Situation im Dresden ihrer Zeit verdeutlichen.

Theresienstadt gehört zu den bekanntesten Haftstätten des „Dritten Reiches“. Der Name steht als Chiffre für die nationalsozialistische Segregation, Verfolgung und Ermordung der Juden. Doch hinter dem plakativ gebrauchten Terminus verschwinden vielfach die Geschichte und der historische Ort. Bis heute existiert keine den neuesten Forschungsstand rezipierende Gesamtdarstellung. Nicht zuletzt aus diesem Grund wurde 2012 die umfangreiche Arbeit von H.G. Adler aus dem Jahr 1955 noch einmal aufgelegt. Adler gehörte als ehemaliger Insasse zu den direkt Betroffenen. Von dessen Studie setzt sich Wolfgang Benz verständnisvoll, doch pointiert ab. Unter Berücksichtigung der aktuellen Literatur gelingt ihm ein ausgewogener Blick auf die Gemeinschaft der Inhaftierten, die als „Zwangsgemeinschaft“ auch im Mittelpunkt der Untersuchung Adlers gestanden hatte. Benz’ Darstellung erweist sich so auch als Zwiegespräch mit dem wirkmächtigen Vorläufer.

The Social Geography of Britain's 19th century towns and cities has tended to find its focus, with a few notable exceptions, in the larger English industrial towns. Residential differentiation and population mobility have been favourite them In contrast, this study is a broad based one highlighting smaller Scottish settlements over the 1861 to 1891 period. Residential differentiation and population mobility, at the mezo - rather than the micro-scale, are considered but so are the Dumbarton and the Vale of Leven were chosen as subjects, being spatially close and yet historically and industrially very different. Dumbarton, a Royal Burgh since 1222, industrialized very rapidly in the period considered here, in the second an The main primary source for this study has been the census enumerators books for the years 1861, 1871, 1881 and 1891. The total sample consisting of 3,800 census families (400 from Dumbarton, 400 from the Vale of Leven for 1861; 500 from either After a consideration of previous work on 19th century towns, particularly that on residential differentiation and on migration (Chapters 2 and 3) local context is provided through use of the printed census reports for Dumbarton and the Vale of L Industrial and occupational structures are the subjects of Chapters 8, 9 and 10. A major contrast being the differing role of the sexes in the employed sector of each community. The changing social structure, through time and at either locationn In the industrializing West of Scotland population was very mobile. Migration was vital to the growth of industrial towns and it is a major theme here. Net inflows and outflows of `local' and `non-local' born adults are discussed in paral The Irish were the most distinct ethnic group from outwith the study area and its regional setting. Their reception, assimilation, migrational trends and their occupational and social structures are contrasted with those of the `nearby Scot Finally Chapters 16 and 17 examine residential differentiation by occupation, social status and ethnic group. Both within these chapters and in the concluding chapter (Chapter 18) attempts are made to separate the particular from the general

Στην παρούσα μεταπτυχιακή εργασία καταβάλλεται μια προσπάθεια αξιολόγησης δύο σύγχρονων ηλεκτρονικών λεξικών της αγγλικής γλώσσας. Πρόκειται για τα λεξικά διπλής κατεύθυνσης "Χρυσή Έκδοση 2002" Αγγλικό-Ελληνικό Ελληνικό-Αγγλικό Λεξικό της Ματζέντα Ε.Π.Ε. και "G-Word for Windows 1993, Version 1.04" της Singular A.E. Ειδικότερα, έχοντας τρία διαφορετικά σημεία αναφοράς, τη δομική σύγκριση ανάμεσα στα προαναφερόμενα λεξικά, την εξέταση του βαθμού ισοδυναμίας που επιτυγχάνεται σε καθένα από αυτά μεταξύ της γλώσσας-προέλευσης και της γλώσσας-στόχου, καθώς και τη γενικότερη εκτίμηση της χρηστικότητάς τους, η παρούσα μεταπτυχιακή εργασία κινείται πάνω σε τρεις διαφορετικούς άξονες. Ωστόσο, δομικά αποτελείται από πέντε κύρια κεφάλαια. Το πρώτο είναι καθαρά θεωρητικό, με τις πρώτες υποενότητες να αναφέρονται στις γενικές αρχές που διέπουν τις λέξεις. Όμως, γρήγορα το βάρος στρέφεται στο ζήτημα της ορθής δόμησης των δίγλωσσων λεξικών. Στο σημείο αυτό τίθενται αναλυτικά όλα τα είδη, καθώς και οι προϋποθέσεις που πρέπει να τηρούνται κατά τη δημιουργία και το σχεδιασμό τους. Επίσης, θίγονται σοβαρά ζητήματα, όπως σε ποιους απευθύνονται τελικά τα δίγλωσσα λεξικά, ποιες οι προσδοκίες των χρηστών τους, κτλ. Τα θέματα που μας απασχολούν στο δεύτερο κεφάλαιο είναι κατά πόσο τελικά μπορεί να ισχύει η έννοια της ισοδυναμίας, κατά πόσο επηρεάζει η δήλωση και η συνδήλωση τα δίγλωσσα λεξικά και, τέλος, κατά πόσο περιπλέκουν την ήδη δυσχερή κατάσταση οι συμφράσεις και οι ιδιωτισμοί. Το τρίτο κεφάλαιο επικεντρώνεται στην αντιπαραβολή των τεχνικών χαρακτηριστικών που έχουν να επιδείξουν τα προαναφερόμενα λεξικά διπλής κατεύθυνσης, ενώ στο τέταρτο κεφάλαιο αναλύονται όλα τα επιμέρους θέματα της αξιολόγησης λεξικών. Ζητήματα όπως οι μέθοδοι που χρησιμοποιούνται, τα κριτήρια που τίθενται, σε συνδυασμό με τις πραγματικές ανάγκες των χρηστών, εξετάζονται αρχικά μόνο θεωρητικά, ενώ στη συνέχεια καθορίζονται με απόλυτη ακρίβεια και σαφήνεια τα ειδικά μεθοδολογικά εργαλεία που θα τεθούν σε εφαρμογή για την αξιολόγηση της Χρυσής Έκδοσης 2002 και του G-Word 1993. Η εμπεριστατωμένη αξιολόγηση που ακολουθεί στο πέμπτο κεφάλαιο και η οποία βασίζεται στα δείγματα του προσαρτήματος, αποκαλύπτει άμεσα τις αδυναμίες των δύο υπό αξιολόγηση λεξικών. Σημειώνεται ότι η αξία της εν λόγω κριτικής αποτίμησης δεν αποβλέπει στο να προσφέρει γρήγορες και αβασάνιστες συνταγές για την ορθή δόμηση δίγλωσσων λεξικών, αλλά κυρίως να πραγματευθεί τα διάφορα προβλήματα που ανακύπτουν από τη χρήση τους και να εξηγήσει, μέσα στο πλαίσιο του δυνατού, τους λόγους για τους οποίους τα συγκεκριμένα λεξικά οργανώθηκαν όπως οργανώθηκαν, δηλαδή τις βάσεις πάνω στις οποίες στηρίχθηκαν.
-

AbstractThe concentrations of a number of polybrominated substances were determined in pooled human milk samples collected from up to 80 countries from all the United Nations Regional Groups. The samples were taken from one or more of the five exposure studies on persistent organic pollutants coordinated by the World Health Organization and the United Nations Environment Programme between 2000 and 2019.Large differences in levels were found for polybrominated diphenyl ethers (PBDE). The concentration of the sum of 6 PBDE congeners (∑PBDE6: BDE-47, BDE-99, BDE-100, BDE-153, BDE-154, BDE-183) of 135 pooled samples from 80 countries was in the range between 0.3 and 352 ng/g lipid (median 1.6 ng/g lipid). The highest concentrations were detected in the Western European and Others Group (including Australia, Israel, New Zealand, and the USA) in 2003. Time trends were assessed for 36 countries with repeated participation. Rates of decrease tend to fluctuate at near background levels; but at higher levels, a decreasing trend was observed for nearly all countries. Deca-BDE (BDE-209) contributed on average about 13% to ∑PBDE7 (sum of ∑PBDE6 plus BDE-209). The contribution of the octa-brominated diphenyl ether (octa-BDE) BDE-197 and nona-BDEs-206, -207, and -208 to the sum of 25 PBDE was in the range of the six recommended analytes and BDE-209. Therefore, their addition to the list of recommended analytes should be considered.The α-HBCDD levels of 102 pooled samples from 72 countries collected between 2006 and 2019 ranged between <0.1 and 15 ng/g lipid (median: 0.5 ng/g lipid). β-HBCDD and γ-HBCDD were in nearly all samples below the limit of quantification (LOQ for 90% of the samples: <0.1 ng/g lipid) or around the LOQ (max: 0.8 ng/g lipid). Thus, it can be concluded that α-HBCD is the predominant stereoisomer in human milk.Hexabromobiphenyl (PBB 153) was below the limit of quantification (0.5 ng/g lipid) in 106 of 110 pooled samples from 69 countries. In four samples, low concentrations of between 1.0 and 1.7 ng/g lipid were found.In addition to these chemicals listed by the Stockholm Convention on Persistent Organic Pollutants, in 38 pooled samples from 28 countries concentrations of polybrominated dibenzodioxins and -furans (PBDD/PBDF) were determined to assess their contribution to the overall sum of WHO2005 toxic equivalents (TEQ) with polychlorinated dibenzo-p-dioxins (PCDD) and polychlorinated dibenzofurans (PCDF). PBDD and PBDF provided on average about 10% to the overall TEQ calculated as sum of WHO-PCDD/PCDF-TEQ and WHO-PBDD/PBDF-TEQ, when assuming the same toxic equivalency factors for brominated congeners as assigned to their chlorinated analogs. No correlations between PCDD/PCDF and PBDD/PBDF, or PBDD/PBDF and PBDE were found.

Abstract Indian mustard (Brassica juncea L.) is the most important oilseed crop of the state of Jharkhand in India, where 78% of the cultivable soil is acidic, causing a sizeable yield reduction. Potential seed yield from such soils cannot be realized within existing varieties and therefore a mutation breeding approach has been followed to isolate mutants tolerant to acidic soil. Three doses of gamma-rays (900 Gy, 1000 Gy and 1100 Gy) and a combined treatment of gamma irradiation and 0.3% EMS were used for induction of mutation in the varieties 'Shivani' and 'Pusa Bold'. A total of 139,720 M₂ plants (75,760 of 'Shivani' and 63,960 of 'Pusa Bold') were screened under acidic soil conditions (pH 4.8). A wide spectrum of variability for tolerance to soil acidity, earliness, seed colour, seed yield and yield components, and morphological traits was observed in the M₂ generation. True-breeding mutants for different traits were confirmed in the M₃ generation. Mutations were recorded in 'Shivani' and 'Pusa Bold', respectively, for secondary branch number (38 and 24), siliquae per plant (1223 and 562) and single plant seed yield (45.49 g and 34.84 g). In addition, a large spectrum of variability for morphological characters was identified.

AbstractThe concentrations of polychlorinated naphthalenes (PCN) were determined in 40 pooled human milk samples from 39 countries covering all five of the United Nations regional groups. The samples were collected in the 2016–2019 exposure studies on persistent organic pollutants coordinated by the United Nations Environment Programme (UNEP).The median concentration of the sum of 26 PCN was 55 pg/g lipid (range 27 pg/g to 170 pg/g). Human milk from European countries showed considerably higher levels than those found in milk from countries in the African, Asia-Pacific, and Latin America/Caribbean regions. The most abundant congeners were the congener pairs PCN 52/60 and PCN 66/67 (inseparable by conventional chromatography) and to a lesser extent PCN 28/36, PCN 42, PCN 46, PCN 48, PCN 59, and PCN 69.Among other adverse biological effects, a critical response of many PCN congeners is dioxin-like toxicity. So, in addition to reporting concentrations of individual congeners, the toxic equivalents (TEQ) were also calculated in these samples, using two sets of relative effect potency (REP) values: a set that has been used in a number of human exposure studies and another set reported by Falandysz et al. (J Environ Sci Health, Part C: Environ Carcinogenesis Ecotoxicol Rev 32(3):239–272, 2014). The median PCN-TEQ concentration in human milk was 0.07 pg PCN-TEQ/g lipid (range 0.03 pg/g to 0.23 pg/g), when calculated using the human biomonitoring study REPs, and 0.03 pg PCN-TEQ/g lipid (range 0.01 pg/g to 0.10 pg/g), when calculated with other suggested REPs. The vast majority, about 90%, of this TEQ can be attributed to the PCN 66/67 congener pair. Individual REPs for PCN 66 and 67 from in vivo studies are quite different, but a chromatographic separation of these two congeners is not possible under routine GC conditions. Different approaches to estimate the uncertainties showed that the value of the REPs used is more important than the analytical problem to separate PCN 66 and PCN 67. PCN-TEQ based on the two sets of REPs differ approximately by a factor of 2.2, whereas the congener-specific determination was estimated to result in approximately 30% lower concentrations in comparison with the standard method.The assessment of PCN 66 and PCN 67 in order to obtain confirmed TEF would be most important for calculations of the dioxin-like toxicity of PCN, followed by PCN 69. Minor contributions to PCN-TEQ concentrations in human milk come from PCN 52/60, PCN 64/68, PCN 70, and PCN 73.On average, the contribution of PCN-TEQ to the cumulative TEQ (including the overall sum of toxic equivalents of PCDD, PCDF, and dioxin-like PCB [WHO2005-TEQ]) is between 1% and 2%, with a wider range of up to 5% for the 39 countries of this study. This is about an order of magnitude lower than the contribution of dioxin-like PCB to the cumulative TEQ (median 26%). In line with the observed higher total PCN concentrations, European countries also showed considerably higher levels of PCN-TEQ than found in the other regions. PCN-TEQ calculated with REPs used in human biomonitoring studies add on average about 2% to the cumulative TEQ of dioxin-like contaminants in Africa, the Asia-Pacific region, and Latin American and Caribbean countries and about 4% in European countries. The corresponding contribution of PCN-TEQ calculated using the other set would be 1% in non-European countries and 2% in European countries.

AbstractThe analytical method used for the determination of polychlorinated biphenyls (PCB), polychlorinated dibenzo-p-dioxins (PCDD), and polychlorinated dibenzofurans (PCDF) in human milk comprised extraction of lipids, the use of 51 13C12-labelled PCB and PCDD/PCDF as internal standards, several chromatographic purification steps, and high resolution gas chromatographic/high resolution mass spectrometric measurement. As an accredited laboratory since 1998, a comprehensive quality control programme has been applied to assure the long-time reliability of results of human milk samples received for WHO/UNEP-coordinated exposure studies between 2000 and 2019. This included procedural blanks, the use of fortified vegetable oil and numerous quality control samples as an in-house reference material, duplicate analyses, and successful participation in 32 proficiency tests (PTs) covering 81 samples of food of animal origin or human milk. Trueness was estimated from the PT samples in the relevant range for human milk above 1 pg WHO-TEQ/g lipid: The deviation was less than 10% from the assigned values for WHO-PCDD/PCDF-PCB-TEQ and WHO-PCDD/PCDF-TEQ and less than about 15% for WHO-PCB-TEQ for about 90% of the results. For the sum of six non-dioxin-like PCB (relevant occurrence range, 1–1000 ng/g lipid), approximately 90% of the results differed by less than 15% from the assigned values. A long-term precision of <15% (coefficient of variation of within-laboratory reproducibility) was achieved, based on quality control samples analysed between 2000 and 2019.The analytical methodology used fulfilled the requirements of the general criteria for the operation of testing laboratories as laid down in EN ISO/IEC 17025, the analytical criteria for PCDD/PCDF and PCB in feed and food specified in EU legislation, and the criterion for monitoring information for Parties to the Stockholm Convention.

This study examined the effects of concentrate supplementation levels on skin quality in crossbred sheep (Awassi X Bonga; AB, Awassi X Washera; AW, and Dorper X Menz; DM). The lambs (44 in total) were randomly assigned to different breed and supplementation groups. They grazed on natural pasture and received 300, 600, or 900 grams of concentrate feed with 21% crude protein and 14 MJ/kg metabolizable energy. After 90 days, the animals were culled, and their skins were assessed. Higher concentrate supplementation (900 g) significantly improved skin weight, size, thickness, and tear load (p < 0.05). Moisture content, fat content, and hide substance percentage were not significantly affected by the supplementation level (p > 0.05). DM breed showed higher thickness, tear load, and moisture content for raw skin compared to AB and AW (p < 0.05). Skins from DM with 900 g supplementation exhibited superior quality. The study concluded that skins from different breeds with concentrate supplementation (300 to 900 g) showed improved leather production within acceptable standards. Further research is recommended for indigenous sheep breeds in different regions, considering crossbreeding levels.

Abstract The V31 containment vessel was procured by the US Army Recovered Chemical Material Directorate (RCMD) as a third-generation EDS containment vessel. It is the fifth EDS vessel to be fabricated under Code Case 2564 of the 2019 ASME Boiler and Pressure Vessel Code, which provides rules for the design of impulsively loaded vessels. The explosive rating for the vessel, based on the code case, is 24 lb (11 kg) TNT-equivalent for up to 1092 detonations. This report documents the results of explosive tests that were performed on the vessel at Sandia National Laboratories in Albuquerque, New Mexico to qualify the vessel for field operations use. There were three design basis configurations for qualification testing. Qualification test (1) consisted of a simulated M55 rocket motor and warhead assembly of 24 lb (11 kg) of Composition C-4 (30 lb [14 kg] TNT equivalent). This test was considered the maximum load case, based on modeling and simulation methods performed by Sandia prior to the vessel design phase. Qualification test (2) consisted of a regular, right circular cylinder, unitary charge, located central to the vessel interior of 19.2 lb (8.72 kg) of Composition C-4 (24 lb [11 kg] TNT equivalent). Qualification test (3) consisted of a 12-pack of regular, right circular cylinders of 2 lb (908 g) each, distributed evenly inside the vessel (totaling 19.2 lb [8.72 kg] of C-4, or 24 lb [11 kg] TNT equivalent). All vessel acceptance criteria were met.

Abstract Lanthanum orthophosphate with the monazite structure was proposed on examinations as a suitable matrix for immobilization of future americium-containing liquid wastes, which could be formed in conversion of metallic plutonium into oxide at PA “Mayak.” Specimens of monazite non-active ceramics were fabricated from LaPO4 powders obtained using a thin-film evaporator by either hot-pressing or cold-pressing and sintering at 900–1300 °C. According to electron microprobe analysis (EMPA), scanning electron microscopy (SEM), and X-ray diffraction (XRD), which were used for characterization of produced samples, all specimens did not contain any phase other than the monoclinic monazite phase. Ceramics having the specific activity of Am-241 2.13×107 Bq/g were prepared by only cold-pressing with subsequent sintering at 1300°C during 1 hour. The normalized leach rates of lanthanum and americium in distilled water at 90°C were less than 1.2×10−4 and 2.3 10−4 g/m2×day, respectively.

Šio darbo tikslas yra ištirti vario jonų koncentracijos įtaką sintetinio majenito adsorbcinei gebai. Nustatyta, kad CaO-Al2O3-H2O sistemoje hidroterminės sintezės metu susidaro majenito prekursorius – katoitas bei lieka nedidelis kiekis portlandito. Antrajame sintezės etape katoitas buvo išdegtas 1 h 900 °C temperatūroje, kurioje jis visiškai suskyla ir susidaro majenitas, šio proceso metu identifikuotas ir portlandito skilimo produktas CaO. Nustatyta, kad 900 °C tem-peratūroje degto produkto paviršiaus plotas lygus 24,55 m2/g. Ištirta, kad bandinio porų paviršiuje susidaro stabilus ad-sorbuoto N2 vienmolekulis sluoksnis, esant santykiniams slėgiams 0,05 < p/p0 < 0,35 ir apskaičiuota CBET konstantos vertė patvirtina, kad SBET skaičiavimai yra patikimi. Tyrimo rezultatai parodė, kad bandiniui yra būdingas histerezės reiškinys ir kad bandinyje vyrauja cilindrinės formos poros. Ištirta, kad didėjant vario jonų koncentracijai tirpale, maksimalus įsiterpusių vario jonų į sintetinio majenito struktūrą, taip pat didėjo nuo 50,5 mg/g iki 167 mg/g. Šio proceso metu efektyvumas pagal pradinio tirpalo koncentraciją yra toks: 1 g/l – 50 %; 2,5 g/l – 36 %; 5 g/l – 33 %. Nustatyta, kad vario jonai adsorbcijos procesai Cu(NO3)2 sistemoje vyksta gerokai efektyviau nei CuSO4 sistemoje. Ištirta, kad po 1 h proceso, naudojant mažiausios koncentracijos Cu(NO3)2 tirpalą, visi skystoje terpėje esantys vario jonai įsiterpę į majenito struktūrą, o CuSO4 sistemoje – tik 167 mg/g. Nustatyta, kad į sintetinio majenito struktūrą sorbcijos metu terpi-asi ne tik vario jonai bet ir sulfato bei nitrato anijonai, kurie proceso metu visiškai persikristalizuoja į kitus giminingus junginius.

Natural declining of oil and gas fields are inherent. It also occurs in the Banyu Urip field. Banyu Urip has been producing since 2009. The field has produced more than 540 million barrel oil (MMBO) with peak production around 220,000 barrel oil per day (BOPD) in 2021, currently producing about 170,000 BOPD. The field’s decline is observed from increasing gas to oil ratio (GOR) and water cut in almost all of the producer wells. The aim of this paper is to describe our efforts to offset Banyu Urip’s production decline by developing a new infill drilling program which has been characterized through an integrated approach by incorporating available static and updated dynamic data. Banyu Urip has a luxury set of subsurface data which we use to support the reservoir characterization and field performance analysis. Static and dynamic data, including production data and hydrocarbon contact monitoring are acquired regularly. In 2017, seismic data reprocessing was conducted with recent technology to improve data quality for better structural and stratigraphic interpretation. Integrating all of the available data with new interpretations and insights provided a better understanding of gross rock volume, reservoir characterization, fluid contact movement, subsurface risks uncertainties, and hydrocarbon volumes. Ultimately, improved geologic and reservoir simulation models were constructed that lead to identification of potential un-swept oil in the Banyu Urip carbonate reservoir area. Mining the existing data and applying new insights regarding subsurface evaluation and reservoir performance analysis resulted in new opportunity identification. The un-swept oil potential is identified mainly in the eastern and western areas. Several infill wells are planned to be drilled in late 2024 onwards which could generate incremental oil production to offset current decline and support national oil production.

Abstract This paper describes a CMOS implementation of novel accelerometers that operate based on heat convection, requiring no solid proof mass. The devices consist of microheaters and thermocouple or thermistor temperature sensors separated by a gap and placed in differential or bridge configurations. Temperature sensors measure the temperature difference between the two sides of the microheater caused by the effect of acceleration on free convection in the surrounding gas. The devices show a small linearity error of &lt; 0.5% under tilt conditions from −90 to 90 degrees, and &lt; 2% under acceleration from 0 g to 7 g. Sensitivity of the devices is also a nearly linear function of heater power (temperature). Sensitivity of up to 115 μV/g was measured for thermopile configuration, and up to 185 μV/g for thermistor configuration. Both types of devices are operable up to frequencies of several hundred hertz.

Abstract An experimental investigation was carried out to analyze the thermal performance of a thermosyphon that recovers waste heat from automobile exhaust using a limited fluid charge in this study. The thermosyphon was constructed from Inconel alloy 625. The outer diameter of the thermosyphon measures 27 mm, with a thickness of 2.6 mm, and an overall length of 483 mm, which includes a 180-mm evaporator, a 70-mm adiabatic section, a 223-mm condenser, and a 97-mm finned exchanger. The study involved directing exhaust gas onto the evaporator end cap at a flow rate ranging from 0–10 g/sec, with temperatures varying from 300–900°C. The impact of three parameters, namely the inclination angle (ranging from 5°–45°), water mass (ranging from 2 g–5.3 g), and the amount of non-condensable gas Argon (ranging from 0 g–0.6 g), were analyzed to determine their effects on the thermal performance of the thermosyphon. Based on the experimental results, it was observed that when the thermosyphon contained 3 g of water and 0.0564g of argon, the condenser achieved a maximum temperature of approximately 200°C. The optimal fuel loading rate for the thermosyphon lies within the range of 0.2 g/s to 0.7 g/s. Furthermore, outer wall temperatures of the thermosyphon increase as inclination angles increase due to the explicit expansion of the actual heating area within the evaporation section of the thermosyphon, accompanied by an augmented gravitational component of the water flux. An increase in the quantity of non-condensable gas (NCG) can diminish temperature gradients on the outer wall of the thermosyphon, leading to a reduction in the thermosyphon’s performance. The insulation applied at the adiabatic section proved effective in increasing temperature gradients on the outer wall of the thermosyphon and thereby enhancing the performance of the thermosyphon. With an increase in the water charge within the thermosyphon, heat transfer rates from the exhaust to the thermosyphon and from the thermosyphon to the fuel increase.

The paper presents the results of scientific research related to the study of adsorption processes of Bacillus subtilis bacteria on activated carbon obtained from apple wood. The activated carbons used have a specific BET area of about 2018 m2/g and a total sorption volume of the pores equal to 1,573 cm3/g. The study of the kinetics of the adsorption processes of the Bacillus subtilis bacteria showed that the value of the maximum adsorption for the fraction 630-800 μm is established within 90 min. The maximum adsorption capacity is 0,54-0,55 McF*108/g, higher than activated charcoal obtained from apricot stones that has the values of 0,375-0,385 at 27oC. The peak of the adsorption is noticed after 90 minutes of the contact and is presented in the figure bellow: Figure 1. Adsorption isotherm of B. subtilis bacterium on AC-apple, fraction 630-800 μm at 27oC The kinetics of the adsorption processes of activated carbon obtained from apple wood (fraction 8002000 μm) for the same bacteria were evaluated at 27oC. The main sorptive properties were attested after 90 to 120 minutes of contact. The adsorption values are in the range of 0,21-0,25 McF*108/g depending on the contact time, lower than in the case of the fraction 630-800 μm and are approximately at the level of activated carbons obtained from apricot stones tested at 37oC. The peak of the adsorption is noticed after 120 minutes of contact. We can conclude that the sorption capacity of the activated carbon of the fraction 630800 μm obtained from apple wood is 2 times higher than in the case of the 800-2000 μm fraction of the same carbons for the B. subtilis bacterial species.

Abstract During the August 2018 ASME Committee Week, a Code Change Inquiry was presented to the Working Group on Operating Plant Criteria (WGOPC): Question 1: Is it the intent of G-2110 to limit RTT0 use to ferritic materials with specified minimum room temperature yield strengths 50 ksi or less? Question 2: If the reply to Question 1 is “No”, is it the intent of G-2110 that G-2110(b) requirement must be met before RTT0 may be used for ferritic materials above 50 ksi but not exceeding 90 ksi? During that meeting the WGOPC replied “no” to both questions. This paper provides an evaluation of available fracture toughness data augmented by an understanding of the underlying mechanisms of cleavage fracture to demonstrate the veracity of the WGOPC’s answer with regards to RTT0 and, more generally, with respect to the Master Curve.

1.1 Resumen macroeconómico En el segundo trimestre la economía enfrentó varios choques, principalmente de oferta y de costos, la mayoría de los cuales no fueron anticipados, o los previstos fueron más persistentes de lo esperado, y que en conjunto interrumpieron la recuperación de la actividad económica observada a comienzos de año y llevaron la inflación total a niveles superiores a la meta. La inflación básica (sin alimentos ni regulados: SAR) aumentó, pero se mantuvo baja y acorde con lo esperado por el equipo técnico. A comienzos de abril se inició una tercera ola de pandemia, más acentuada y prolongada que la anterior, con un elevado costo en vidas humanas y algún impacto negativo en la recuperación económica. Entre mayo y mediados de junio los bloqueos de las carreteras y los problemas de orden público tuvieron un fuerte efecto negativo sobre la actividad económica y la inflación. Se estima que la magnitud de estos dos choques combinados habría generado una caída en niveles en el producto interno bruto (PIB) con respecto al primer trimestre del año. Adicionalmente, los bloqueos causaron un aumento significativo de los precios de los alimentos. A estos choques se sumaron los efectos acumulados de la disrupción global en algunas cadenas de valor y el incremento en los fletes internacionales que desde finales de 2020 vienen generando restricciones de oferta y aumentos de costos. Todos estos factores, que afectaron principalmente el índice de precios al consumidor (IPC) de bienes y de alimentos, explicaron la mayor parte del error de pronóstico del equipo técnico y el aumento de la inflación total a niveles superiores a la meta del 3 %. El incremento en la inflación básica y de los precios de los regulados fue acorde con lo esperado por el equipo técnico, y se explica principalmente por la eliminación de varios alivios de precios otorgados un año atrás. A todo esto se suma la mayor percepción de riesgo soberano y las presiones al alza que esto implica sobre el costo de financiamiento externo y la tasa de cambio. A pesar de los fuertes choques negativos, el crecimiento económico esperado para la primera mitad del año (9,1%), es significativamente mayor que lo proyectado en el informe de abril (7,1%), signo de una economía más dinámica que se recuperaría más rápido de lo previsto. Desde finales de 2020 las diferentes cifras de actividad económica han mostrado un crecimiento mayor que el esperado. Esto sugiere que los efectos negativos sobre el producto de las recurrentes olas de contagio estarían siendo cada vez menos fuertes y duraderos. No obstante, la tercera ola de contagio del Covid-19, y en mayor medida los bloqueos a las vías y los problemas de orden público, habrían generado una caída del PIB durante el segundo trimestre, frente al primero. Pese a lo anterior, los datos del índice de seguimiento a la economía (ISE) de abril y mayo han resultado mayores que lo esperado, y las nuevas cifras de actividad económica sectoriales sugieren que el impacto negativo de la pandemia sobre el producto se sigue moderando, en un entorno de menores restricciones a la movilidad y de mayor avance en el ritmo de vacunación. Los registros de transporte de carga (junio) y la demanda de energía no regulada (julio), entre otros, indican una recuperación importante después de los bloqueos en mayo. Con todo lo anterior, el incremento anual del PIB del segundo trimestre se habría situado alrededor del 17,3 % (antes 15,8 %), explicado en gran parte por una base baja de comparación. Para todo 2021 el equipo técnico incrementó su proyección de crecimiento desde un 6 % hasta el 7,5 %. Este pronóstico, que está rodeado de una incertidumbre inusualmente elevada, supone que no se presentarán problemas de orden público y que posibles nuevas olas de contagio del Covid-19 no tendrán efectos negativos adicionales sobre la actividad económica. Frente al pronóstico del informe pasado, la recuperación de la demanda externa, los niveles de precios de algunos bienes básicos que exporta el país y la dinámica de las remesas de trabajadores han sido mejores que las esperadas y seguirían impulsando la recuperación del ingreso nacional en lo que resta del año. A esto se sumaría la aún amplia liquidez internacional, la aceleración en el proceso de vacunación y las bajas tasas de interés, factores que continuarían favoreciendo la actividad económica. La mejor dinámica del primer semestre, que llevó a una revisión al alza en el crecimiento de todos los componentes del gasto, continuaría hacia adelante y, antes de lo esperado en abril, la economía recuperaría los niveles de producción de 2019 a finales de 2021. El pronóstico continúa incluyendo efectos de corto plazo sobre la demanda agregada de una reforma tributaria de magnitud similar a la proyectada por el Gobierno. Con todo eso, en el escenario central de este informe, el pronóstico de crecimiento para 2021 es del 7,5 % y para 2022 del 3,1 %. A pesar de esto, el nivel de la actividad económica seguiría siendo inferior a su potencial. La mejora en estas proyecciones, sin embargo, está rodeada de una alta incertidumbre. En junio la inflación anual (3,63 %) aumentó más de lo esperado debido al comportamiento del grupo de alimentos, mientras que la inflación básica (1,87 %) fue similar a la proyectada. En lo que resta del año el mayor nivel del IPC de alimentos persistiría y contribuiría a mantener la inflación por encima de la meta. A finales de 2022 la inflación total y básica retornarían a tasas cercanas al 3 %, en un entorno de desaceleración del IPC de alimentos y de menores excesos de capacidad productiva. En los meses recientes el aumento en los precios internacionales de los fletes y de los bienes agrícolas, y las mayores exportaciones de carne y el ciclo ganadero han ejercido presiones al alza sobre el precio de los alimentos, principalmente de los procesados. A estas fuerzas persistentes se sumaron los bloqueos de las vías nacionales y los problemas de orden público en varias ciudades registrados en mayo y parte de junio, los cuales se reflejaron en una fuerte restricción en la oferta y en un aumento anual no esperado del IPC de alimentos (8,52 %). El grupo de regulados (5,93 %) también se aceleró, debido a la baja base de comparación en los precios de la gasolina y a la disolución de parte de los alivios a las tarifas de servicios públicos otorgados en 2020. Como se proyectaba, la inflación SAR repuntó al 1,87 %, debido a la reactivación de los impuestos indirectos de algunos bienes y servicios eliminados un año atrás, y por las presiones al alza que ejercieron los alimentos sobre las comidas fuera del hogar (CFH), entre otros. En lo que resta del año se espera que el aumento en los alimentos perecederos se revierta, siempre y cuando no se registren nuevos bloqueos duraderos a las vías nacionales. El mayor nivel de precios de los alimentos procesados persistiría y contribuiría a mantener la inflación por encima de la meta a finales de año. La inflación SAR continuaría con una tendencia creciente, en la medida en que los excesos de capacidad productiva se sigan cerrando y registraría un aumento transitorio en marzo de 2022, debido principalmente al restablecimiento del impuesto al consumo en las CFH. Con todo esto, para finales de 2021 y 2022 se estima una inflación total del 4,1 % y 3,1 %, y una inflación básica del 2,6 % y 3,2 %, respectivamente. El comportamiento conjunto de los precios del IPC SAR, junto con continuas sorpresas al alza en la actividad económica, son interpretados por el equipo técnico como señales de amplios excesos de capacidad productiva de la economía. Estos persistirían en los siguientes dos años, al final de los cuales la brecha del producto se cerraría. El mayor crecimiento económico sugiere una brecha del producto menos negativa que la estimada hace un trimestre. Sin embargo, el comportamiento de la inflación básica, especialmente en servicios, indica que el PIB potencial se ha recuperado de forma sorpresiva y que los excesos de capacidad siguen siendo amplios, con una demanda agregada afectada de forma persistente. Esta interpretación encuentra soporte en el mercado laboral, en donde persiste un desempleo alto y la recuperación de los empleos perdidos se estancó. Adicionalmente, los aumentos en la inflación en buena medida están explicados por choques de oferta y de costos y por la disolución de algunos alivios de precios otorgados un año atrás. Los pronósticos de crecimiento y de inflación descritos son coherentes con una brecha del producto que se cierra más rápido y es menos negativa en todo el horizonte de pronóstico con respecto al informe de abril. No obstante, la incertidumbre sobre los excesos de capacidad es muy alta y es un riesgo sobre el pronóstico. Las perspectivas de las cuentas fiscales de Colombia se deterioraron, Standard & Poor’s Global Ratings (S&P) y Fitch Ratings (Fitch) redujeron su calificación crediticia, los bloqueos y problemas de orden público afectaron el producto y el país enfrentó una nueva ola de contagios de Covid-19 más acentuada y prolongada que las pasadas. Todo lo anterior se ha reflejado en un aumento de las primas de riesgo y en una depreciación del peso frente al dólar. Esto ha ocurrido en un entorno favorable de ingresos externos. Los precios internacionales del petróleo, del café y de otros bienes básicos que exporta el país aumentaron y han contribuido a la recuperación de los términos de intercambio y del ingreso nacional, y han mitigado las presiones al alza sobre las primas de riesgo y la tasa de cambio. En el presente informe se incrementó el precio esperado del petróleo para 2021 a USD 68 por barril (antes USD 61 bl) y para 2022 a USD 66 bl (antes USD 60 bl). Esta mayor senda presenta una convergencia hacia precios menores que los observados recientemente, como resultado de una mayor oferta mundial esperada de petróleo, la cual más que compensaría el incremento en la demanda de este bien básico. Por ende, se supone que el aumento reciente de los precios tiene un carácter transitorio. En el escenario macroeconómico actual se espera que las condiciones financieras internacionales sean algo menos favorables, a pesar de la mejora en los ingresos externos por cuenta de una mayor demanda y unos precios del petróleo y de otros productos de exportación más altos. Frente al informe de abril el crecimiento de la demanda externa fue mejor que el esperado, y las proyecciones para 2021 y 2022 aumentaron del 5,2 % al 6,0 % y del 3,4 % al 3,5 %, respectivamente. En lo corrido del año las cifras de actividad económica muestran una demanda externa más dinámica de la esperada. En los Estados Unidos y China la recuperación del producto ha sido más rápida que la registrada en los países de la región. En estos últimos la reactivación económica ha estado limitada por los rebrotes del Covid-19, las limitaciones en la oferta de vacunas y el poco espacio fiscal para enfrentar la pandemia, entre otros factores. La buena dinámica en el comercio externo de bienes se ha dado en un entorno de deterioro en las cadenas de valor y de un aumento importante en los precios de las materias primas y en el costo de los fletes. En los Estados Unidos la inflación sorprendió al alza y su valor observado y esperado se mantiene por encima de la meta, al tiempo que se incrementó la proyección de crecimiento económico. Con esto, el inicio de la normalización de la política monetaria en ese país se daría antes de lo proyectado. En este informe se estima que el primer incremento en la tasa de interés de la Reserva Federal de los Estados Unidos se dé a finales de 2022 (antes del primer trimestre de 2023). Para Colombia se supone una mayor prima de riesgo frente al informe de abril y se sigue esperando que presente una tendencia creciente, dada la acumulación de deuda pública y externa del país. Todo esto contribuiría a un incremento en el costo del financiamiento externo en el horizonte de pronóstico. La postura expansiva de la política monetaria sigue soportando unas condiciones financieras internas favorables. En el segundo trimestre la tasa de interés interbancaria y el índice bancario de referencia (IBR) se han mantenido acordes con la tasa de interés de política. Las tasas de interés promedio de captación y crédito continuaron históricamente bajas, a pesar de algunos incrementos observados a finales de junio. La cartera en moneda nacional detuvo su desaceleración anual y, entre marzo y junio, el crédito a los hogares se aceleró, principalmente para compra de vivienda. La recuperación de la cartera comercial y de los desembolsos a ese sector fue importante, y se alcanzó de nuevo el elevado saldo observado un año atrás, cuando las empresas requirieron niveles significativos de liquidez para enfrentar los efectos económicos de la pandemia. El riesgo de crédito aumentó, las provisiones se mantienes altas y algunos bancos han retirado de su balance una parte de su cartera vencida. No obstante, las utilidades del sistema financiero se han recuperado y sus niveles de liquidez y solvencia se mantienen por encima del mínimo regulatorio. A partir de este informe se implementará una nueva metodología para cuantificar y comunicar la incertidumbre que rodea los pronósticos del escenario macroeconómico central, en un entorno de política monetaria activa. Esta metodología se conoce como densidades predictivas (DP) y se explica en detalle en el Recuadro 1. Partiendo del balance de riesgos que contiene los principales factores que, de acuerdo con el juicio del equipo técnico, podrían afectar a la economía en el horizonte de pronóstico, la metodología DP produce distribuciones de probabilidad sobre el pronóstico de las principales variables (v. g.: crecimiento, inflación). Estas distribuciones reflejan el resultado de los posibles choques (a variables externas, precios y actividad económica) que podría recibir la economía y su transmisión, considerando la estructura económica y la respuesta de política monetaria en el futuro. En este sentido, permiten cuantificar la incertidumbre alrededor del pronóstico y su sesgo. El ejercicio DP muestra un sesgo a la baja en el crecimiento económico y en la brecha del producto, y al alza en la inflación. El balance de riesgos indica que las disyuntivas para la política monetaria serán potencialmente más complejas que lo contemplado en el pasado. Por el lado de las condiciones de financiamiento externo, se considera que el mayor riesgo es que se tornen un poco menos favorables, en un escenario en el cual la Reserva Federal de los Estados Unidos incremente con mayor prontitud su tasa de interés. Esto último, ante un crecimiento económico y del empleo mayor que el esperado en los Estados Unidos que genere presiones significativas sobre la inflación de ese país. A esto se suma la incertidumbre sobre el panorama fiscal en Colombia y sus efectos sobre la prima de riesgo y el costo del financiamiento externo. En el caso del crecimiento, la mayoría de los riesgos son a la baja, destacándose los efectos de la incertidumbre política y fiscal sobre las decisiones de consumo e inversión, la aparición de nuevas olas de contagio de la pandemia del Covid-19 y sus impactos sobre la actividad económica. En el caso de la inflación, se incorporó el riesgo de una mayor persistencia de los choques asociados con la disrupción de las cadenas de valor, mayores precios internacionales de las materias primas y de los alimentos, y una recuperación más lenta que la esperada de la cadena agrícola nacional afectada por los pasados bloqueos a las vías. Estos riesgos presionarían al alza principalmente los precios de los alimentos y de los bienes. Como principal riesgo a la baja se incluyó un alza de los arriendos menor que el esperado en el escenario central, explicada por una demanda débil y por una mayor oferta en 2022 dadas las altas ventas de vivienda observadas en el presente año. Con todo, el crecimiento económico presenta un sesgo a la baja y, con el 90 % de confianza, se encontraría entre un 6,1 % y 9,1 % para 2021 y entre el 0,5 % y 4,1 % para 2022. La brecha del producto tendría un sesgo a la baja, principalmente en 2022. El sesgo de la inflación es al alza, y se encontraría entre el 3,7 % y 4,9 % en 2021, y el 2,2 % y 4,7 % en 2022, con un 90 % de probabilidad. 1.2 Decisión de política monetaria En las reuniones de junio y julio la JDBR decidió mantener la tasa de política monetaria inalterada en 1,75 %.

This is a two-part study. See report L51712 for part two. The integrity of girth weld defects in gas transmission pipelines is ensured by non-destructive inspection procedures. The acceptance level of pipeline girth weld defects revealed by non-destructive testing is commonly based on workmanship quality control. Workmanship defect acceptance levels, however, are based on experience and are, by necessity, both arbitrary and often conservative. An alternative approach of defect acceptance in pipeline girth welds is based on the concept of fitness-for-purpose. This report describes the results of an experimental investigation into the failure behavior of defected girth welds in large diameter line pipes. The focal point of the evaluations was the study of the weld metal yield strength matching effects on weld metal root crack tolerance. The objectives were achieved by testing six girth welds in API5LX65 pipe sections of 916 mm (36 in.) in diameter with a 25,4 mm(1 in.) wall thickness. The girth welds were made with 90 ksi (E9010-G) tensile strength -low toughness- cellulosic electrodes. This electrode was chosen to obtain weld deposit yield strength overmatching.