Artykuły w czasopismach na temat „Fu shu zhong xue”

Use of herbal medicine is popular among cancer patients. This study aimed to explore the coprescription of CHM and WM among prostate cancer patients in Taiwan. This cross-sectional retrospective study used a population-based database containing one million beneficiaries of National Health Insurance. Claims and prescriptions were analyzed. In 2007, 218 (22.4%) prostate cancer patients were CHM users. Among CHM users, 200 (91.7%) patients with 5618 (79.5%) CHM prescriptions were on coprescription of CHM and WM. A total of 484 types of CHM and 930 types of WM were used. The most commonly used CHMs on coprescription were Shu Jing Huo Xue Tang, Ma Zi Ren Wan, and Xue Fu Zhu Yu Tang. The most commonly used WMs on coprescription were magnesium oxide, amlodipine, and aspirin. The average number of prescriptions per user per year was 261.2 versus 151.7 in all (P<0.001), 123.6 versus 76.9 in WM (P=0.033), and 34.8 versus 5.1 in CHM (P<0.001) for patients with and without coprescription, respectively. In conclusion, use of CHM among prostate cancer patients was popular in Taiwan. Most CHMs were used with WM concurrently. The potential drug-herb interactions should be investigated, especially for patients with more prescriptions.

ObjectivesPatients with type 2 diabetes have a higher risk of colorectal cancer (CRC), but whether Chinese herbal medicines (CHMs) can reduce this risk is unknown. This study investigated the effect that CHMs have on CRC risk in patients with type 2 diabetes.Research design and methodsThis cohort study used the Taiwanese National Health Insurance Research Database to identify 54 744 patients, newly diagnosed with type 2 diabetes, aged 20–70 years, who were receiving treatment between 1998 and 2007. From this sample, we randomly selected 14 940 CHMs users and 14 940 non-CHMs users, using propensity scores matching. All were followed through 2012 to record CRC incidence. Cox proportional hazards regression was used to compute the hazard ratio (HR) of CRC by CHMs use.ResultsDuring follow-up, 235 CHMs users and 375 non-CHMs users developed CRC, incidence rates of 1.73% and 2.47% per 1000 person-years, respectively. CHM users had a significantly reduced risk of CRC compared with non-CHM users (adjusted HR=0.71; 95% CI 0.60 to 0.84). The greatest effect was in those receiving CHMs for more than 1 year. Huang-Qin, Xue-Fu-Zhu-Yu-Tang, Shu-Jing-Huo-Xue-Tang, Liu-Wei-Di-Huang-Wan, Ji-Sheng-Shen-Qi-Wan, Gan-Lu-Yin, Shao-Yao-Gan-Cao-Tang and Ban-Xia-Xie-Xin-Tang were significantly associated with lower risk of CRC.ConclusionIntegrating CHMs into the clinical management of patients with type 2 diabetes may be beneficial in reducing the risk of CRC.

There are no completely grammatical studies in Chinese scholarly tradition prior to 1898. Mainly commentary orientation of linguistic works and the general tendency towards the lexicographic form of presentation of philological researches determined function words’ dictionaries to be the leading way of describing linguistic phenomena in the field of grammar. Turning to treatises of this kind contributes to the study of linguistic traditions’ generation and grammatical researches’ formation in China. Special attention is paid to the description of grammatical meanings’ development from lexical one’s and to method of exegesis based on such description, used in《助字辨略》 «Zhu Zi Bian Lüe» (1711) by 刘淇 LiuQi. The structure of the dictionary entries of this work was analyzed, as well as the interpretations in which LiuQi refers to the significant meanings of the described units. Examples of dictionary entries are given, or excerpts from them, provided with translations into Russian. The analysis of the material showed that dictionary entries can vary significantly in length, their internal structure is also not the same, however, in general, it includes an explanation of the meaning of the described unit (from authoritative sources such as 《尔雅》 «Erya», 《广韵》 «Guangyun» and/or a comment made by the author of «Zhu Zi Bian Lüe») and illustrative material from classical works (such as 《论语》 «Lun yu», 《大学》 «Da xue», 《中庸》 «Zhong yong», 《孟子》 «Mencius», 《诗经》 «Shi jing», 《汉书》 «Han shu», etc.). In a number of dictionary entries, LiuQi demonstrates the mechanism of grammatical meanings’ development from the significant one, emphasizing that the grammatical meaning is determined by the significant meaning and is closely connected with it.

Lithium-sulfur (Li-S) batteries feature a high theoretical capacity of 1675 mAh/g and hence is considered as a promising alternative to lithium-ion batteries. However, deployment of Li-S batteries has been hindered by the low practical energy and limited cycle life.1, 2 Reducing cathode porosity is essential to balancing the electrolyte distribution in Li-S cell, conserving more pore-filling electrolyte to extend cell cycle life.3-5 However, low-porosity electrodes built with nanosized sulfur/carbon (S/C) materials suffer from high tortuosity that significantly deteriorates electrode wetting and hence sulfur utilization. Enabling operation of high-loading sulfur electrodes under both low-porosity and lean-electrolyte conditions is still a challenge and is seldom discussed. In this study,6 we demonstrated a novel and facile strategy for constructing low-tortuosity through-pores across both vertical and planar directions of electrodes by casting large particles into single-particle-layer electrodes. Through multi-scale characterizations and simulations, correlations between material/electrode structures, electrolyte permeability, polysulfide migration, and sulfur reactions were elucidated. The high-loading and dense sulfur cathode fabricated by this method delivers a high specific capacity (>1000 mAh g-1) at a very low electrolyte/sulfur (E/S) ratio of 4 μL mg-1. This study provides a novel approach to reducing the tortuosity of dense sulfur electrodes by manipulating the porosity distribution, which would be also applicable to improving the rate capability of other high-energy electrodes. More details of the progress will be discussed at the meeting. Reference. Dörfler, S.; Althues, H.; Härtel, P.; Abendroth, T.; Schumm, B.; Kaskel, S., Challenges and Key Parameters of Lithium-Sulfur Batteries on Pouch Cell Level. Joule 2020, 4 (3), 539-554. Xue, W.; Miao, L.; Qie, L.; Wang, C.; Li, S.; Wang, J.; Li, J., Gravimetric and volumetric energy densities of lithium-sulfur batteries. Current Opinion in Electrochemistry 2017, 6 (1), 92-99. Lu, D.; Li, Q.; Liu, J.; Zheng, J.; Wang, Y.; Ferrara, S.; Xiao, J.; Zhang, J. G.; Liu, J., Enabling High-Energy-Density Cathode for Lithium-Sulfur Batteries. ACS Appl Mater Interfaces 2018, 10 (27), 23094-23102. Kang, N.; Lin, Y.; Yang, L.; Lu, D.; Xiao, J.; Qi, Y.; Cai, M., Cathode porosity is a missing key parameter to optimize lithium-sulfur battery energy density. Nat Commun 2019, 10 (1), 4597. Feng, S.; Liu, J.; Zhang, X.; Shi, L.; Anderson, C.; Lin, Y.; Song, M.-K.; Liu, J.; Xiao, J.; Lu, D., Rationalizing nitrogen-doped secondary carbon particles for practical lithium-sulfur batteries. Nano Energy 2022, 103. Feng, S.; Singh, R. K.; Fu, Y.; Li, Z.; Wang, Y.; Bao, J.; Xu, Z.; Li, G.; Anderson, C.; Shi, L.; Lin, Y.; Khalifah, P. G.; Wang, W.; Liu, J.; Xiao, J.; Lu, D., Low-tortuous and dense single-particle-layer electrode for high-energy lithium-sulfur batteries. Energy & Environ. Sci. 2022.

The integrity of Chinese culture itself has led to Buddhism being predominantly associated with religion, while in terms of aesthetics, there were numerous theoretical works during the Wei, Jin, Southern and Northern Dynasties in China, with highly active thoughts. Works such as Lu Ji's "Wen Fu," Zhong Rong's "Shi Pin," Liu Xie's "Wen Xin Diao Long," and Xie He's "Gu Hua Pin Lu" emerged as a large body of aesthetic and artistic works. Therefore, the influence of Buddhism on Chinese aesthetic consciousness is prominently represented by the Zen thought influenced by native Daoist philosophy, which also reflects a positive aspect in facing real life. It presents an aesthetic taste of "joy" and "carefree." The core of Chinese aesthetics is not limited to the ethical aspect of Confucian aesthetics, but rather stems from the Daoist concept of "harmony between heaven and man" and the perception of nature. Before the introduction of Buddhism, Japan did not form a complete and systematic aesthetic concept. Moreover, the natural environment of the disaster-prone Japanese archipelago was not superior. With the entry of Buddhism into Japan and its dominance in Japanese culture, a pessimistic attitude towards the world quickly permeated the aesthetic consciousness of Japan, which lacked a conscious ideological system. This difference in aesthetic expression is manifested in the characters of "qu" and "ji" .

Abstract Background: Antiangiogenic drugs have demonstrated synergistic effect with anti-PD-1 antibody in advanced triple negative breast cancer (TNBC). Anlotinib is an oral multi-target tyrosine kinase inhibitor (TKI) that strongly inhibits VEGFR, PDGFR, FGFR, and c-kit. Preclinical studies showed that metronomic chemotherapy inhibited angiogenesis and enhanced the efficacy of immunotherapy in TNBC via modulation of the tumor immune microenvironment. We hereby conducted a single-arm, multicenter, phase II trial to investigate the efficacy and safety of sintilimab (anti-PD-1 antibody) plus anlotinib and metronomic chemotherapy as a potential novel therapeutic strategy in advanced TNBC and explore potential biomarkers. Methods: Forty-four cases were planning to be included in this trial. The eligible patients who had received no more than two lines of chemotherapy for metastatic disease were enrolled and received sintilimab (200 mg iv q3w) and anlotinib (12 mg po d1-14 q3w) plus capecitabine (500 mg po, tid) or vinorelbine (40 mg po, tiw) until disease progression or intolerable toxicity. The primary endpoint is objective response rate (ORR) and secondary endpoints are disease control rate (DCR), progression free survival (PFS), and overall survival (OS). The safety profile has also been assessed. Results: As of April 2023, a total of 44 patients were enrolled, and 42 patients were evaluable for efficacy. 3 patients (7.1%) achieved complete response (CR). 6 patients (14.3%) achieved partial response (PR). 25 patients (59.5%) achieved stable disease (SD).The ORR is 21.4% (95%CI 0.103-0.368) and DCR is 81.0% (95%CI 0.810-0.659). The median PFS was 5.06 months (95%CI 2.051-8.069). The most common grade 1 or 2 adverse events (AEs) include elevated thyroid stimulating hormone (52.38%, 22/42), elevated bilirubin (23.81%, 10/42), hand-foot syndrome (22.22%, 8/42), leukopenia (16.67%,7/42), nausea (14.29%, 6/42). Grade 3 AEs include elevated bilirubin (2.38%, 1/42), hypertension (2.38%, 1/42) and herpes zoster (2.38%, 1/42). No grade 4 or 5 AEs occurred. Conclusions: Our date showed that sintilimab in combination with anlotinib plus metronomic chemotherapy have shown favorable efficacy and acceptable safety profile in patients with advanced TNBC. Clinical trial information: ChiCTR2100044725 Citation Format: huihui Li, Dongdong Zhou, Zeshun Yv, Yuqian Liao, Jie Huang, Shujuan Sun, fangchao zheng, Baojiang Li, Shu Fang, Ling Qiang, Guohua Ren, Bing Bu, Pengfei Qiu, Xinzhao Wang, Chao Li, Fangli Cao, Qian Shao, Dali Han, Lihua Song, Baoxuan Zhang, Bingjie Fan, Liang Xu, Xuemei Xie, Xianguang Zhao, Lanping Liu, Wanlong Li, Zhenbo Wang, Changmin Liu, Hui Fu, Xiao Sun, Zhiqiang Shi, Fengxiang Li. Efficacy and safety of sintilimab in combination with anlotinib plus metronomic chemotherapy in advanced triple negative breast cancer (SPACE): preliminary results of a single-arm, multicenter phase II trial [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO3-06-07.

Electric and magnetic energy densities as well as energy flux (Poynting vector) for radial variant vector beam focusing through a dielectric interface is analyzed numerically based on vector diffraction theory. The electric and magnetic energy densities are tailored by properly manipulating the radial as well as initial phases to generates novel focal patterns in the focal area. These peculiar properties may find applications in fields such as optical trapping, optical recording, magnetic recording, and magnetic resonance microscopy and semiconductor inspection. Full Text: PDF References S.N. Khonina, I. Golub, "Optimization of focusing of linearly polarized light ", Opt. Lett. 36 352 (2011). CrossRef V.V. Kotlyar, S.S. Stafeev, Y. Liu, L. O'Faolain, A. A. Kovalev, "Analysis of the shape of a subwavelength focal spot for the linearly polarized light", Appl. Opt. 52 330 (2013). CrossRef S. Sen, M.A. Varshney, D. Varshney, "Relativistic Propagation of Linearly/Circularly Polarized Laser Radiation in Plasmas", ISRN Optics. 2013 1 (2013). CrossRef M. Martínez-Corral, R. Martínez-Cuenca, I. Escobar, G. Saavedra, "Reduction of focus size in tightly focused linearly polarized beams", Appl. Phys. Lett. 85 4319 (2004) . CrossRef J. Lekner, "Polarization of tightly focused laser beams", Opt. A: Pure Appl. Opt. 5, 6 (2003). CrossRef H. Guo, X. Weng, M. Jiang, Y. Zhao, G. Sui, Q. Hu, Y. Wang, S. Zhuang, "Tight focusing of a higher-order radially polarized beam transmitting through multi-zone binary phase pupil filters", Opt.Express 21, 5363 (2013). CrossRef C.-C. Sun, C.-K. Liu, "Ultrasmall focusing spot with a long depth of focus based on polarization and phase modulation", Opt. Lett. 28, 99 (2003). CrossRef G.H. Yuan, S.B. Wei, X.-C. Yuan, "Nondiffracting transversally polarized beam", Opt. Lett. 36, 3479 (2011). CrossRef P. Yu, S. Chen, J. Li, H. Cheng, Z. Li, W. Liu, B. Xie, Z. Liu, J. Tian, "Generation of vector beams with arbitrary spatial variation of phase and linear polarization using plasmonic metasurfaces", Opt. Lett. 40, 3229 (2015). CrossRef Z. Chen, T. Zeng, B. Qian, "Complete shaping of optical vector beams", J. Ding, Opt. Express 23, 17701 (2015). CrossRef Z. Liu, Y. Liu, Y. Ke, Y. Liu, W. Shu, H. Luo, S. Wen, "Generation of arbitrary vector vortex beams on hybrid-order Poincaré sphere", Photon. Res. 5, 15 (2017). CrossRef Z. Man, Z. Bai, S. Zhang, J. Li, X. Li, X. Ge, Y. Zhang, S. Fu, "Focusing properties of arbitrary optical fields combining spiral phase and cylindrically symmetric state of polarization", J. Opt. Soc. Am. A 35, 1014 (2018). CrossRef Z. Man, S. Fu, G. Wei, "Focus engineering based on analytical formulae for tightly focused polarized beams with arbitrary geometric configurations of linear polarization", J. Opt. Soc. Am. A 34, 1384 (2017). CrossRef Z. Man et al, "Optical cage generated by azimuthal- and radial-variant vector beams", Appl. Opt. 57 (2018). CrossRef S.S. Stafeev, V.V Kotlyar, A.G. Nalimov, E.S. Kozlova, "The Non-Vortex Inverse Propagation of Energy in a Tightly Focused High-Order Cylindrical Vector Beam", IEEE Photon. J., 11, 1 (2019). CrossRef S.S. Stafeev, V.V. Kotlyar, "Elongation of the area of energy backflow through the use of ring apertures", Opt. Commun.450 (2019) 67-71. CrossRef S.S. Stafeev, V.V. Kotlyar, A.G. Nalimov, "Energy backflow in in a tightly focused high-order cylindrical vector beam", Proc. SPIE 11025, 1102518 (2019). CrossRef N.G. Orji, M. Badaroglu, B.M. Barnes, "Metrology for the next generation of semiconductor devices", Nat. Electron. 1, 532 (2018). CrossRef P. Torok, P. Varga, G.R. Booker, "Electromagnetic diffraction of light focused through a planar interface between materials of mismatched refractive indices: structure of the electromagnetic field. I", I, J. Opt. Soc. Am. A 12, 2136 (1995). CrossRef P. Torok, P. Varga, Z. Laczik, G.R. Booker, "Electromagnetic diffraction of light focused through a planar interface between materials of mismatched refractive indices: an integral representation", J. Opt. Soc. Am. A., 12, 325 (1995). CrossRef Z. Zhou, L. Zhu, "Tight focusing of high order axially symmetric polarized beams through a dielectric interface", Optik, 124, 2219 (2013). CrossRef J. Shu, Z. Chen, J. Pu, Y. Liu "Tight focusing of a double-ring-shaped, azimuthally polarized beam through a dielectric interface", J. Opt. Soc. Am. A 31, 1180 (2014). CrossRef K. Hu, Z. Chen, J. Pu., "Generation of super-length optical needle by focusing hybridly polarized vector beams through a dielectric interface", Opt. Lett. 37, 3303 (2012). CrossRef B. Richards, E. Wolf, "Electromagnetic diffraction in optical systems, II. Structure of the image field in an aplanatic system", Proc. R. Soc. London A 253, 358 (1959). CrossRef

Parents play an important role in the development of their children. This research reflects the role of parents in developing children. Through four stages of identification, screening, eligibility, and acceptable results, this method uses a systematic literature review using the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-analyses) method. The findings from the fourteen articles examined show that parenting skills play an important role in a child's growth and development from birth to death. The determining factor in the development of physical, motoric, moral, language, social-emotional, and life skills aspects is the role of both parents as important teachers for children from birth to adulthood. Parents can also use a variety of parenting strategies and skills, many of which they have learned throughout their lives and passed on to their children, to help their children grow. 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Background: Based on their anti-oxidative and anti-fibrotic properties, Angelica sinensis (Oliv.) Diels roots [Apiaceae; Radix Angelicae sinensis] (Danggui [abbreviated as S in the context]), Astragalus membranaceus (Fisch.) Bunge [Fabaceae; Astragalus membranaceus] (Huangqi [A]), Rheum palmatum L. [Polygonaceae; Rheum palmatum] (Dahuang [R]), and Salvia miltiorrhiza Bunge [Lamiaceae; Salvia miltiorrhiza Bunge radix et rhizoma] (Danshen [D]) are potential renoprotective Chinese herbal medicines (CHMs). Renoprotection using ARD alone for the treatment of chronic kidney disease (CKD) has been documented in pre-clinical, clinical, and meta-analysis research; however, only pre-clinical data are available for the use of S alone. Moreover, with an increasing number of CKD patients taking prescribed CHMs, hyperkalemia risk remains unclear.Methods: This study retrospectively analyzed national health insurance claims data in 2001–2017. Propensity score matching was used to analyze renal and survival outcomes and the dose-response effects of S without ARD use in 18,348 new S users, 9,174 new ARD users, and 36,696 non-users. Cox proportional hazard regression was used to investigate adjusted hazard ratios (aHRs) for end-stage renal disease (ESRD) in the presence of competing mortality and death. The additive effect of the S herb in single form to compounds was also analyzed. Additionally, to analyze hyperkalemia risk, an exact match on each covariate was used to include 42,265 new CHM users and non-users, while Poisson regression was used to estimate adjusted incidence rate ratios (aIRRs) of hyperkalemia of prescribed CHMs.Results: S users and ARD users were associated with aHRs of 0.77 (95% confidence interval; 0.69–0.86) and 1.04 (0.91–1.19), respectively, for ESRD and 0.55 (0.53–0.57) and 0.71 (0.67–0.75), respectively, for death. The renal and survival benefits of S use were consistent in several sensitivity analyses. The dose- and time-dependent renoprotection and dose-dependent survival benefits were observed for S use. The top two additive renoprotective collocations of the S herb in compounds were Xue-Fu-Zhu-Yu-Tang and Shen-Tong-Zhu-Yu-Tang, followed by Shu-Jing-Huo-Xue-Tang and Shen-Tong-Zhu-Yu-Tang. Moreover, CHM users were associated with aIRRs of 0.34 (0.31–0.37) for hyperkalemia.Conclusion: This study suggests dose- and time-dependent renoprotection and dose-dependent survival benefits of the S herb in compounds and no increased hyperkalemia risk of the prescribed CHMs in CKD patients.

Ethnopharmacology relevance: Yunnan Baiyao (YNBY), a traditional Chinese medicine formulae, has some significant properties including activating blood circulation to dissipate blood stasis (Huo-Xue-Hua-Yu), eliminating swelling and alleviating pain (Xiao-Zhong-Zhi-Tong), and eliminating necrotic tissues and promoting granulation (Qu-Fu-Sheng-Ji).Aim of this study: This paper intends to provide a comprehensive and critical analysis of studies on YNBY, proposing new possible therapeutic directions of this formula.Materials and methods: Relevant data on YNBY were retrieved from available databases and a hand-search by searching the keywords such as “Yunnan Baiyao,” “pharmacology,” “toxicity,” and “clinical applications.”Results: Traditionally, YNBY has been used to cure hemorrhage, bruises, swelling, and pain caused by injuries in the Chinese folk. Modern pharmacological studies show that YNBY possesses pharmacological activities including hemostasis, invigorating the circulation of blood, wound healing, anti-inflammation, analgesia, antibiosis, infection prevention, and other effects. Toxicological studies demonstrate that YNBY has a certain toxicology, which is mainly caused by Aconitum alkaloids from Cao-wu (CW, Aconiti Kusnezoffii Radix). The developmental non-toxic reaction dose (NOAEL) of YNBY for embryos and fetuses is 0.5 g/kg in rats. In addition, the NOAEL for fertility and early embryo development toxicity is 4.0 g/kg in rats. Clinical trials have confirmed the safety of YNBY in a large number of patients, and adverse drug reactions (ADRs) such as abdominal pain, diarrhea, allergy, and others in very few people. YNBY is routinely used in clinic to cure bleeding, pain, swelling, upper digestive tract ulcer, postoperative wound, arthritis, mouth ulcers, ulcerative colitis, etc.Conclusions: Hemostasis is a conspicuous effect of YNBY. Except for this effect, analgesia and anti-infection may be new research directions of this formula. In addition, the in vitro and in vivo pharmacology and mechanisms of action of YNBY are encouraged as well as the pharmacokinetics of this formulae. Furthermore, the material basis of the pharmacological effects of YNBY also needs clear identification.

LANGUAGE NOTE | Document text in Chinese; abstract also in English. 鍾嶸論任昉詩風特點有四：一曰拓體淵雅，二曰善銓事理，三曰競須新事，四曰詞不貴奇。拓體淵雅，即文體和正，聲調雅致。善銓事理，即依事行文，文理相合。任昉將這兩種“筆法”用於寫詩，對南朝詩歌的“筆化”、“文化”起到了推動作用。此外，任昉還將肇於建安，興於晉宋，經傅咸、應璩、顏延之、謝靈運、謝莊、劉駿等人發揚的指事之法引入齊梁詩壇，成任昉詩派。任昉作詩喜引新事，不拘外家内家、正史别史，都拓體淵雅，近於儒家，與追求直致與奇格的道家詩風有别。Zhong Rong (fl. 502-519) summed up four main aspects in his discussion of the characteristics of Ren Fang’s (460-508) poetry: 1) erudition and refinement, 2) clear expression, 3) an effort to use new allusions, and 4) no pursuit for the grotesque. “Erudition and refinement” referred to the elegant style and harmonious sound of Ren’s poetry, while “clear expression” meant Ren’s ability to give a realistic representation of the object. These two aspects were important features of prose writing, yet Ren applied these techniques to poetry composition. As a result, he made a significant contribution to Southern dynasties poetry by initiating a change in style from shi (verse) to bi (essay) and wen (prose). He also founded a Ren Fang “school” by introducing the technique of using allusions in the Qi-Liang poetic arena. The practice of using allusions in poetic works began in the Jian’an era (196-220), and thrived during the Jin and Song dynasties (265-479) in the hands of Fu Xian (239-294), Ying Qu (190-252), Yan Yanzhi (384-456), Xie Lingyun (385-433), Xie Zhuang (421-466), and Liu Jun (430-464). Ren Fang was fond of many different kinds of new allusions to sources by various scholars and historians. His poetic style was profound and refined. It was close to Confucianism but different from Daoism, which pursued straightforwardness and the grotesque.

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Object segmentation is an important task which is widely employed in many computer vision applications such as object detection, tracking, recognition, and retrieval. It can be seen as a two-phase process: object detection and segmentation. Object segmentation becomes more challenging in case there is no prior knowledge about the object in the scene. In such conditions, visual attention analysis via saliency mapping may offer a mean to predict the object location by using visual contrast, local or global, to identify regions that draw strong attention in the image. However, in such situations as clutter background, highly varied object surface, or shadow, regular and salient object segmentation approaches based on a single image feature such as color or brightness have shown to be insufficient for the task. This work proposes a new salient object segmentation method which uses a depth map obtained from the input image for enhancing the accuracy of saliency mapping. A deep learning-based method is employed for depth map estimation. Our experiments showed that the proposed method outperforms other state-of-the-art object segmentation algorithms in terms of recall and precision. KeywordsSaliency map, Depth map, deep learning, object segmentation References[1] Itti, C. Koch, E. Niebur, A model of saliency-based visual attention for rapid scene analysis, IEEE Transactions on pattern analysis and machine intelligence 20(11) (1998) 1254-1259.[2] Goferman, L. Zelnik-Manor, A. Tal, Context-aware saliency detection, IEEE transactions on pattern analysis and machine intelligence 34(10) (2012) 1915-1926.[3] Kanan, M.H. Tong, L. Zhang, G.W. Cottrell, Sun: Top-down saliency using natural statistics, Visual cognition 17(6-7) (2009) 979-1003.[4] Liu, Z. Yuan, J. Sun, J. Wang, N. Zheng, X. Tang, H.-Y. Shum, Learning to detect a salient object, IEEE Transactions on Pattern analysis and machine intelligence 33(2) (2011) 353-367.[5] Perazzi, P. Krähenbühl, Y. 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Jawahar, Depth really matters: Improving visual salient region detection with depth., in: BMVC, 2013.Li, J. Ye, Y. Ji, H. Ling, J. Yu, Saliency detection on light field, in: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition, 2014, pp. 2806-2813.Koch, S. Ullman, Shifts in selective visual attention: towards the underlying neural circuitry, in: Matters of intelligence, Springer, 1987, pp. 115-141.Laina, C. Rupprecht, V. Belagiannis, F. Tombari, N. Navab, Deeper depth prediction with fully convolutional residual networks, in: 3D Vision (3DV), 2016 Fourth International Conference on, IEEE, 2016, pp. 239-248.Bruce, J. Tsotsos, Saliency based on information maximization, in: Advances in neural information processing systems, 2006, pp. 155-162.Ren, X. Gong, L. Yu, W. Zhou, M. Ying Yang, Exploiting global priors for rgb-d saliency detection, in: Proceedings of the IEEE Conference on Computer Vision and Pattern Recognition Workshops, 2015, pp. 25-32.Fang, J. Wang, M. Narwaria, P. Le Callet, W. Lin, Saliency detection for stereoscopic images., IEEE Trans. Image Processing 23(6) (2014) 2625-2636.Hou, L. Zhang, Saliency detection: A spectral residual approach, in: Computer Vision and Pattern Recognition, 2007. CVPR’07. IEEE Conference on, IEEE, 2007, pp. 1-8.Guo, Q. Ma, L. Zhang, Spatio-temporal saliency detection using phase spectrum of quaternion fourier transform, in: Computer vision and pattern recognition, 2008. cvpr 2008. ieee conference on, IEEE, 2008, pp. 1-8.Fang, W. Lin, B.S. Lee, C.T. Lau, Z. Chen, C.W. Lin, Bottom-up saliency detection model based on human visual sensitivity and amplitude spectrum, IEEE Transactions on Multimedia 14(1) (2012) 187-198.Lang, T.V. Nguyen, H. Katti, K. Yadati, M. Kankanhalli, S. Yan, Depth matters: Influence of depth cues on visual saliency, in: Computer vision-ECCV 2012, Springer, 2012, pp. 101-115.Zhang, G. Jiang, M. Yu, K. Chen, Stereoscopic visual attention model for 3d video, in: International Conference on Multimedia Modeling, Springer, 2010, pp. 314-324.Wang, M.P. Da Silva, P. Le Callet, V. Ricordel, Computational model of stereoscopic 3d visual saliency, IEEE Transactions on Image Processing 22(6) (2013) 2151-2165.Peng, B. Li, W. Xiong, W. Hu, R. Ji, Rgbd salient object detection: A benchmark and algorithms, in: European Conference on Computer Vision (ECCV), 2014, pp. 92-109.Wu, L. Duan, L. Kong, Rgb-d salient object detection via feature fusion and multi-scale enhancement, in: CCF Chinese Conference on Computer Vision, Springer, 2015, pp. 359-368.Xue, Y. Gu, Y. Li, J. Yang, Rgb-d saliency detection via mutual guided manifold ranking, in: Image Processing (ICIP), 2015 IEEE International Conference on, IEEE, 2015, pp. 666-670.Katz, A. Adler, Depth camera based on structured light and stereo vision, uS Patent App. 12/877,595 (Mar. 8 2012).Chatterjee, G. Molina, D. Lelescu, Systems and methods for determining depth from multiple views of a scene that include aliasing using hypothesized fusion, uS Patent App. 13/623,091 (Mar. 21 2013).Matthies, T. Kanade, R. Szeliski, Kalman filter-based algorithms for estimating depth from image sequences, International Journal of Computer Vision 3(3) (1989) 209-238.Y. Schechner, N. Kiryati, Depth from defocus vs. stereo: How different really are they?, International Journal of Computer Vision 39(2) (2000) 141-162.Delage, H. Lee, A.Y. Ng, A dynamic bayesian network model for autonomous 3d reconstruction from a single indoor image, in: Computer Vision and Pattern Recognition, 2006 IEEE Computer Society Conference on, Vol. 2, IEEE, 2006, pp. 2418-2428.Saxena, M. Sun, A.Y. Ng, Make3d: Learning 3d scene structure from a single still image, IEEE transactions on pattern analysis and machine intelligence 31(5) (2009) 824-840.Hedau, D. Hoiem, D. 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Vitamin E (VitE) is a potent antioxidant and contributes as an apoptosis inhibitor by preventing apoptotic death by suppressing cell membrane scrambling with phosphatidylserine translocation and caspase activites. Fas ligand (FasL) is well known to induce cell apoptosis. Activation of phosphoinositide 3 kinase (PI3K) signalling is stimulated by VitE. The present study addressed the effects of VitE on survival of mouse dendritic cells (DCs) and signalling molecules underlying. To this end, mouse bone marrow cells were isolated and cultured to attain bone marrow-derived DCs (BMDCs). The cells were treated with FasL in the presence or absence of VitE. Western blotting and FACS analysis were performed to determine expression of signalling molecules and their involvement in DC apoptosis. As a result, FasL treatment resulted in activation of caspase 8 and an increased number of Annexin V+ cells, the effects were significantly suppressed when VitE was present in the cell culture. Importantly, the anti-apoptotic effects of VitE were abolished by using pharmacological inhibition of PI3K signaling with LY294002. Our results showed that VitE inhibited FasL-mediated DC apoptosis through PI3K signalling, the effect is expected to facilitate the survival of DCs and promote the immune response against pathogens. Keywords Caspase, Dendritic cell; Fas ligand; PI3K and vitamin E. References [1] J. Banchereau, R.M. Steinman, Dendritic cells and the control of immunity, Nature 392 (1998) 245-52.[2] E. Ingulli, A. Mondino, A. Khoruts, M.K. Jenkins, In vivo detection of dendritic cell antigen presentation to CD4(+) T cells, J Exp Med 185 (1997) 2133-41.[3] C. Yang, H.Z. Liu, Z.X. Fu, PEG-liposomal oxaliplatin induces apoptosis in human colorectal cancer cells via Fas/FasL and caspase-8, Cell Biol Int 36 (2012) 289-96.[4] Q.G. Yan, J.G. Shi, F. Zhang, Q.T. Zhao, X.W. Pang, R. Chen, P.Z. Hu, Q.L. Li, Z. Wang, G.S. Huang, Overexpression of CYP2E1 enhances sensitivity of hepG2 cells to fas-mediated cytotoxicity, Cancer Biol Ther 7 (2008) 1280-7.[5] A. Hamai, C. Richon, F. Meslin, F. Faure, A. Kauffmann, Y. Lecluse, A. Jalil, L. Larue, M.F. Avril, S. Chouaib, M. Mehrpour, Imatinib enhances human melanoma cell susceptibility to TRAIL-induced cell death: Relationship to Bcl-2 family and caspase activation, Oncogene 25 (2006) 7618-34.[6] S. Lucken-Ardjomande, J.C. Martinou, Regulation of Bcl-2 proteins and of the permeability of the outer mitochondrial membrane, C R Biol 328 (2005) 616-31.[7] M. Rescigno, V. Piguet, B. Valzasina, S. Lens, R. Zubler, L. French, V. Kindler, J. Tschopp, P. Ricciardi-Castagnoli, Fas engagement induces the maturation of dendritic cells (DCs), the release of interleukin (IL)-1beta, and the production of interferon gamma in the absence of IL-12 during DC-T cell cognate interaction: a new role for Fas ligand in inflammatory responses, J Exp Med 192 (2000) 1661-8.[8] C. 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Provinciali, Gamma- and delta-tocotrienols exert a more potent anticancer effect than alpha-tocopheryl succinate on breast cancer cell lines irrespective of HER-2/neu expression, Life Sci 86 (2010) 668-75.[12] A.A. Albahrani, R.F. Greaves, Fat-Soluble Vitamins: Clinical Indications and Current Challenges for Chromatographic Measurement, Clin Biochem Rev 37 (2016) 27-47.[13] E. Shumilina, N. Zahir, N.T. Xuan, F. Lang, Phosphoinositide 3-kinase dependent regulation of Kv channels in dendritic cells, Cell Physiol Biochem 20 (2007) 801-8.[14] X. Jin, L. Song, X. Liu, M. Chen, Z. Li, L. Cheng, H. Ren, Protective efficacy of vitamins C and E on p,p'-DDT-induced cytotoxicity via the ROS-mediated mitochondrial pathway and NF-kappaB/FasL pathway, PLoS One 9 (2014) e113257.[15] B.C. Richardson, N.D. Lalwani, K.J. Johnson, R.M. Marks, Fas ligation triggers apoptosis in macrophages but not endothelial cells, Eur J Immunol 24 (1994) 2640-5.[16] J. Tschopp, M. Irmler, M. Thome, Inhibition of fas death signals by FLIPs, Curr Opin Immunol 10 (1998) 552-8.[17] J. Chung, Y.O. Yoon, J.S. Lee, T.K. Ha, S.M. Ryu, K.H. Kim, M.H. Jeong, T.R. Yoon, H.K. Kim, Inulin induces dendritic cells apoptosis through the caspase-dependent pathway and mitochondrial dysfunction, Biol Pharm Bull 34 (2011) 495-500.[18] S. Kreuz, D. Siegmund, J.J. Rumpf, D. Samel, M. Leverkus, O. Janssen, G. Hacker, O. Dittrich-Breiholz, M. Kracht, P. Scheurich, H. Wajant, NFkappaB activation by Fas is mediated through FADD, caspase-8, and RIP and is inhibited by FLIP, J Cell Biol 166 (2004) 369-80.[19] S. Buonocore, S. Van Meirvenne, F.X. Demoor, F. Paulart, K. Thielemans, M. Goldman, V. Flamand, Dendritic cells transduced with viral interleukin 10 or Fas ligand: no evidence for induction of allotolerance in vivo, Transplantation 73 (2002) S27-30.[20] D. Ashany, A. Savir, N. Bhardwaj, K.B. 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Introdução: A transmissão SARS-CoV-2 de humano para humano pode ocorrer e o risco de propagação no ar durante os procedimentos odontológicos geradores de aerossóis permanece uma preocupação. Acredita-se que um enxaguatório bucal antimicrobiano pré-operacional reduza o número de micróbios orais. No entanto, a eficácia do enxaguatório bucal pré-procedimento na redução do número de microrganismos disseminados por meio do aerossol gerado por procedimentos odontológicos ainda não está clara. Objetivo: avaliar através de uma revisão de literatura o uso de enxaguantes bucais na redução da carga viral do SARS-CoV-2. Materiais e Método: O levantamento literário para esta pesquisa foi realizado no período de dezembro de 2019 a 10 de agosto de 2020 nas bases de dados Scielo e Medline/PubMed. Na estratégia de busca, foram utilizadas as palavras “SARS-CoV-2”, “2019-nCoV”, “COVID-19”, “Dentistry”, “Odontologia”, “Odontología”, “Mouthwashes”, “Antissépticos Bucais” e “Antisépticos Bucales”. Resultados: Uma busca sistematizada foi realizada, foram encontrados 661 artigos, após a realização da leitura criteriosa dos artigos completos foram selecionados 42 artigos. 88% dos estudos indicavam o uso de Peróxido de hidrogênio a 1%, 76% indicavam Povidine 0,2% e apenas 19% o uso da Clorexidina a 0,12%. Conclusão: Os estudos presentes na literatura apresentam divergências nas indicações e porcentagens dos enxaguantes indicados. Os protocolos clínicos devem ser avaliados para reduzir o risco de transmissão e proteger pacientes e profissionais.Descritores: Infecções por Coronavírus; Betacoronavirus; Odontologia; Antissépticos Bucais.ReferênciasGe ZY, Yang LM, Xia JJ, Fu XH, Zhang YZ. Possible aerosol transmission of COVID-19 and special precautions in dentistry. J Zhejiang Univ Sci B. 2020;21(5):361-68. Peng X, Xu X, Li Y, Cheng L, Zhou X, Ren B. Transmission routes of 2019-nCoV and controls in dental practice. 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Знание величины коэффициента теплопроводности полупроводникового материала необходимо для оценки возможности использования его в качестве термоэлектрика. Абсолютным стационарным методом продольного теплового потока в интервале 50–300 K исследована теплопроводность природных минералов галенита (PbS), халькопирита (CuFeS2), а также керамики ZnS.Образцы были однородными, имели малое содержание примесей (химический состав образцов контролировался ренгенофлюоресцентным методом) и характеризовались высокими значениями удельного электрического сопротивления (r > 9·10–2 Ом·м при комнатной температуре). Это соответствует электронной составляющей теплопроводности ke < 1·10–4 Вт/(м·К). Результаты измерений теплопроводности представлены графически и в табулированном виде. Все зависимости являются убывающими. Величины теплопроводности (Вт/(м·К)) при 50 К составляют 10.9 для PbS, 62 для CuFeS2 и 73–98 для ZnS. При 300 К соответствующие величины равны 2.48, 10.5 и 18.6–18.8 Вт/(м·К).Все исследованные материалы значительно хуже проводят тепло, чем пирит FeS2. Проведено сравнение полученных данных с литературными. Температурная зависимость теплопроводности галенита является слабой, его низкая теплопроводность благоприятна для термоэлектрических приложений. Выявленная в настоящей работе теплопроводность халькопирита оказалась наивысшей из соответствующих литературных данных. Высокая теплопроводность сульфида цинка коррелирует с ее широкой вариабельностью в зависимости от структурных особенностей материала. Рассчитаны температурные зависимости средней длины свободного пробега фононов. Оцененные для температуры плавления значения этой характеристики для PbS и особенно для ZnS значительно превосходят размеры элементарной кристаллической ячейки, что необычно. ЛИТЕРАТУРА Самофалова Т. В., Семенов В. Н., Нитута А. Н., Звягина О. В., Проскурина Е. Ю. 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