Rozprawy doktorskie na temat „Foot and mouth disease”
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Nayak, Arabinda. "Foot and mouth disease virus RNA replication". Thesis, University of Surrey, 2005. http://epubs.surrey.ac.uk/842873/.
Pełny tekst źródłaFoster-Cuevas, Mildred. "Immunodeterminants of foot-and-mouth disease virus". Thesis, University of Hertfordshire, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338562.
Pełny tekst źródłaPuig, Arturo. "Lipopeptide vaccines against foot and mouth disease". Thesis, University College London (University of London), 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.428103.
Pełny tekst źródłaCottam, Eleanor Myfanwy. "Micro-evolution of foot-and-mouth disease virus". Thesis, Connect to e-thesis. Move to record for print version, 2008. http://theses.gla.ac.uk/92/.
Pełny tekst źródłaPh.D. thesis submitted to the Division of Biochemistry and Molecular Biology, Institute of Biomedical and Life Sciences, University of Glasgow, 2008. Includes bibliographical references. Print version also available.
Lea, Susan Mary. "Structural studies on foot-and-mouth disease virus". Thesis, University of Oxford, 1993. http://ora.ox.ac.uk/objects/uuid:438dc0ae-b899-40fd-84dc-03d3fc1a537f.
Pełny tekst źródłaEdacheril, Mathew. "Assessment of herd immunity to foot-and-mouth disease". Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.314315.
Pełny tekst źródłaMahdi, Ali Jafar. "Foot and mouth disease in Iraq: strategy and control". Kansas State University, 2010. http://hdl.handle.net/2097/4620.
Pełny tekst źródłaDepartment of Diagnostic Medicine/Pathobiology
Gary A. Anderson
Foot-and-mouth disease (FMD) is a highly infectious viral disease of cattle, pigs, sheep, goats, buffalo, and artiodactyl wildlife species. Foot-and-mouth disease virus is endemic and periodic devastating epidemics have occurred and caused heavy economic losses in Iraq for a long time. The first official cases of FMD were recorded in 1937, while the first record of a specific FMD serotype in Iraq was serotype A in 1952. Other serotypes have been reported since then; serotypes O, SAT-1 and Asia1 were recorded in 1957, 1962, and 1975, respectively. Veterinary Services in Iraq has been severely weakened over the past two decades, and its infrastructure has been devastated as a consequence of previous political conflicts, wars and international sanctions. The breakdown of Veterinary Services led to the disruption of disease control strategies, collapse of disease surveillance and monitoring, and weakening of response systems. The destruction of the Al-Dora FMD laboratories for diagnosis and vaccine production by the United Nation in 1996, and the restrictions placed on the importation of vaccines have strongly affected the FMD control program. A severe epidemic of FMD occurred in Iraq in 1998, affecting 2.5 million ruminants and causing heavy losses in newly born animals. It is estimated to have killed about 550,000 animals. The outbreak was due to the serotype O1 Middle East strain which has affected large and small ruminants. In 2009, Iraq was severely affected by new serotype A (subtype A Iran 05). The major efforts of Veterinary Services in Iraq have been directed towards control of FMD by vaccination strategies. Two types of vaccine have been used, trivalent vaccine (O, A 22, and Asia 1) for cattle and buffalo and monovalent vaccine (O Manisa) for sheep and goats. Vaccination has been implemented once yearly on a voluntary basis. Sometimes other limited control measures have accompanied vaccination, which include quarantine, movement control, focused vaccination, disinfection, and public awareness programs. The FMD control program in Iraq has been confronted by many challenges: deficits in FMD surveillance and emergency preparedness, limited diagnostic capabilities, difficulties in restricting animal movement, and lack and irregular supply of appropriate vaccines.
Будаєва, І. В., i Г. О. Ревенко. "Hand-foot-and-mouth disease (HFMD) у Дніпропетровському регіоні". Thesis, Сумський державний університет, 2017. http://essuir.sumdu.edu.ua/handle/123456789/64722.
Pełny tekst źródłaClinical and epidemiological particularities of HFMD in children are presented. Considering cardiotropic features enteroviruses ECG and CFK-MB are evaluated in 14 children. Signs of myocarditis are revealed.
Ramanoon, Siti. "The epidemiology of foot and mouth disease in Malaysia". Thesis, Ramanoon, Siti (2016) The epidemiology of foot and mouth disease in Malaysia. PhD thesis, Murdoch University, 2016. https://researchrepository.murdoch.edu.au/id/eprint/32386/.
Pełny tekst źródłaHowes, Emma Louise. "Investigating the foot-and-mouth disease virus 3A protein". Thesis, University of St Andrews, 2018. http://hdl.handle.net/10023/15521.
Pełny tekst źródłaSahle, Mesfin. "An epidemiological study on the genetic relationships of foot and mouth disease viruses in East Africa". Pretoria : [s.n.], 2010. http://upetd.up.ac.za/thesis/available/etd-08132008-095346/.
Pełny tekst źródłaO'Connor, Steven Patrick. "The production of foot-and-mouth disease virus-like particles in the plant Nicotiana benthamiana: a potential candidate vaccine for foot-and-mouth disease". Master's thesis, University of Cape Town, 2018. http://hdl.handle.net/11427/29378.
Pełny tekst źródłaDi, Nardo Antonello. "Phylodynamic modelling of foot-and-mouth disease virus sequence data". Thesis, University of Glasgow, 2016. http://theses.gla.ac.uk/7558/.
Pełny tekst źródłaFry, Elizabeth Evelyn. "The three dimensional structure of foot and mouth disease virus". Thesis, University of Oxford, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.281130.
Pełny tekst źródłaBessell, Paul R. "Spatial epidemiology of Foot and Mouth Disease in Great Britain". Thesis, University of Edinburgh, 2009. http://hdl.handle.net/1842/4831.
Pełny tekst źródłaJochimsen, Aaron A. "The vulnerability of U.S. agriculture to foot and mouth disease". Thesis, Monterey, California: Naval Postgraduate School, 2015. http://hdl.handle.net/10945/45881.
Pełny tekst źródłaThe U.S. livestock industry represents a critical economic infrastructure, due to its size and influence on national and international agricultural systems. The high-concentration farming practices that allow the United States to be a world leader in agriculture also present a vulnerability to biological pathogens, particularly foot and mouth disease (FMD). The purpose of this thesis is to stimulate and broaden the discussion of the U.S. livestock industry’s susceptibility to an FMD outbreak, regardless of how it is introduced. It reviews case studies of prominent outbreaks in the United Kingdom (2001) and Taiwan (1997). The themes that emerged from these case studies—responsibility and response—informed a discussion of ways to increase U.S. efficiency when responding to an FMD outbreak. The case studies illustrate that FMD outbreaks in thriving livestock industries can have devastating economic, social, and political consequences. The United States should address these and other international FMD outbreaks to improve the preparedness and resilience of the U.S. livestock industry to an outbreak of FMD.
Abrams, Charles C. "The biosynthesis of foot-and-mouth disease virus empty capsids". Thesis, University of Reading, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.332255.
Pełny tekst źródłaFlint, Mike. "A study of foot-and-mouth disease virus polyprotein processing". Thesis, University of Reading, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295238.
Pełny tekst źródłaDavidson, Freda Lynn. "Alternative strategies for foot-and-mouth disease control in pigs". Thesis, University of Hertfordshire, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.361189.
Pełny tekst źródłaLudi, Anna Barbara. "Antigenic variation of foot-and-mouth disease virus serotype A". Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.648211.
Pełny tekst źródłaKnight-Jones, Theo. "Field evaluation of foot-and-mouth disease vaccination in Turkey". Thesis, Royal Veterinary College (University of London), 2014. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.618321.
Pełny tekst źródłaBorley, Daryl W. "Epitope dominance studies with serotype O foot-and-mouth disease". Thesis, University of Oxford, 2012. http://ora.ox.ac.uk/objects/uuid:4adc3373-1d89-41d9-b1ce-7d8cbb0e817a.
Pełny tekst źródłaChitray, Melanie. "Investigating potential factors affecting foot-and-mouth disease virus internalisation". Diss., University of Pretoria, 2008. http://hdl.handle.net/2263/30391.
Pełny tekst źródłaDissertation (Msc)--University of Pretoria, 2008.
Veterinary Tropical Diseases
unrestricted
Chitray, Melanie. "Investigating potential factors affecting foot-and-mouth disease virus internalization". Pretoria : [s.n.], 2008. http://upetd.up.ac.za/thesis/available/etd-02192009-165513/.
Pełny tekst źródłaChen, Shih-Ping. "Epidemiology, pathogenesis and surveillance of pig adapted strain of foot and mouth disease in Taiwan /". Murdoch University Digital Theses Program, 2008. http://wwwlib.murdoch.edu.au/adt/browse/view/adt-MU20080813.104029.
Pełny tekst źródłaNgu, Duy Nghia. "Epidemiology and dynamic of hand, foot and mouth disease in Vietnam". Thesis, Montpellier, 2016. http://www.theses.fr/2016MONTT099/document.
Pełny tekst źródłaThis work analyzed all HFMD cases reported in Hai Phong in 2011 and 2012 outbreak which was the largest to have ever occurred in Vietnam and the first recorded in the northern part of the country. Hai Phong city experienced the highest HFMD incidence in North Vietnam. It was thus a good model for investigating the dynamic of the disease without interference and potential remains from previous outbreaks or patient immunological adaptation.The first section is dedicated to a review of the literature on EV-A71 and enteroviruses. The second section is divided in three chapters, each one addressing a specific issue of the project.The first chapter addresses the dynamic of the disease and the role of official guidelines in the handling of the 2011-2012 epidemic. Beside basic epidemiological features, the study also provides findings relating to the influence of HFMD guidelines during the outbreak period that has never been described before. The guideline release led to a significant increase of the severity score and reduced delay between onset and admission. This effect is linked to an increased awareness leading to patients being mostly declared with severe symptoms in order to ensure a better treatment and surveillance. The work presented in this chapter also demonstrated that three waves occurred with different characteristics and caused by three different viruses. Wave 1 and wave 3 were caused by EV-A71 and a combination of CV-A6 and CV-A16, respectively while Wave 2 was caused by an unknown virus. This work is also an integrative analysis including a spatiotemporal analysis. The disease seems to have expanded following the eastbound river system to reach densely populated settlements from where it secondarily expanded through local roads. Owing to the average age of the patients, around 2, the source of contamination must be sought for within asymptomatic adults being contaminated during their occupational activities and in local movements.The second chapter addresses the phylogeny and spatiotemporal distribution of EV-A71 in North Vietnam and provides an insight on the evolution and dynamic of the EV-A71 enterovirus. The VP1 capsid protein was used as target. The first conclusion of this chapter is that the 2011-2012 outbreak was not caused by an incoming strain but by EV-A71 strains which were already present in North Vietnam. This indicates that they can remain in a low level, asymptomatic state, in genomic stasis and with a geographic structuration. The cause for outbreaks should thus be sought for in the socio-economic patterns rather than in exogenous emergence. Another outcome of this chapter is the observed correlation between I/V variant groups and phylogeny, pathogenicity and ethnicity. The I/V pattern at positions 249, 262 and 284 on the VP1 protein might play a role in pathogenicity. The observed correlation of the I/V variant populations with severity and ethnicity strengthen this hypothesis.The last chapter addresses the mathematical modelling of a multiphase disease such as HFMD. It is essential to detect as soon as possible the emergence of new wave, associated to a novel agent. Owing to the large size of the cohort available for this work (ca. 9000 patients), we have been able to develop a differential equation model providing a very high fit with the observed data. The model confirmed that three waves were present in 2011-2012 with differing virulence. It also allows to characterize each wave, detect the start of a new one and associate groups of patients with specific patterns of symptoms.As a conclusion, this PhD work as underlined some key issues to be addressed in a coordinated way in order help developing an efficient surveillance and monitoring system for HFMD in Vietnam
Berryman, Stephen John. "Early events in cell entry by foot-and-mouth disease virus". Thesis, University of Surrey, 2005. http://epubs.surrey.ac.uk/842711/.
Pełny tekst źródłaWong, Yim-ping, i 黃艷萍. "Development of a subunit vaccine against foot-and-mouth disease virus". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1999. http://hub.hku.hk/bib/B31221993.
Pełny tekst źródłaHofner, Maureen Catherine. "A study of foot-and-mouth disease virus pathogenesis in cattle". Thesis, University of London, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338844.
Pełny tekst źródłaFreire, Antonio de Padua. "Epidemiological studies of foot-and-mouth disease in Minas Gerais Brazil". Thesis, University of Reading, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.363661.
Pełny tekst źródłaMcInerney, Gerald Michael. "Trans-encapsidation of capsid-defective foot-and-mouth disease virus replicons". Thesis, University of Reading, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301929.
Pełny tekst źródłaCollen, Trevor. "T cell responses of cattle to foot-and-mouth disease virus". Thesis, Open University, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293303.
Pełny tekst źródłaAli, Shireen. "Origin of replication complexes during foot and mouth disease virus infection". Thesis, University of Hertfordshire, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.302421.
Pełny tekst źródłaSalt, Jeremy Simon. "The immunology of foot and mouth disease virus persistence in cattle". Thesis, University of Hertfordshire, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.358299.
Pełny tekst źródłaMalik, Nayab. "Structural characterisation of the foot-and-mouth disease virus uncoating pathway". Thesis, University of Oxford, 2016. https://ora.ox.ac.uk/objects/uuid:1120387b-eeb1-4a66-a380-06cfe37c5a47.
Pełny tekst źródłaWright, Caroline Frances. "Dissecting the molecular basis of foot-and-mouth disease virus evolution". Thesis, University of Glasgow, 2012. http://theses.gla.ac.uk/4254/.
Pełny tekst źródłaQuan, Melvyn. "Quantitative dynamics of foot-and-mouth disease virus infection in pigs". Thesis, University of Edinburgh, 2005. http://hdl.handle.net/1842/30663.
Pełny tekst źródłaLogan, Grace. "The molecular and genetic evolution of foot-and-mouth disease virus". Thesis, University of Glasgow, 2017. http://theses.gla.ac.uk/7877/.
Pełny tekst źródłaSangare, Oumou. "Molecular epidemiology of foot-and-mouth disease virus in West Africa". Thesis, University of Pretoria, 2002. http://hdl.handle.net/2263/23010.
Pełny tekst źródłaThesis (PhD (Veterinary Tropical Diseases))--University of Pretoria, 2002.
Veterinary Tropical Diseases
unrestricted
Sabanathan, Saraswathy. "Neurodevelopmental outcomes following severe hand foot and mouth disease in Vietnam". Thesis, Open University, 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.699826.
Pełny tekst źródłaWong, Yim-ping. "Development of a subunit vaccine against foot-and-mouth disease virus /". Hong Kong : University of Hong Kong, 1999. http://sunzi.lib.hku.hk/hkuto/record.jsp?B21080161.
Pełny tekst źródłaYoung, James Robert. "Change management for sustainable foot-and-mouth disease control in Cambodia". Thesis, The University of Sydney, 2017. http://hdl.handle.net/2123/17038.
Pełny tekst źródłaSenawi, Jamaliah. "Epidemiology of Foot and Mouth Disease in Cattle in Pahang, Malaysia". Thesis, Senawi, Jamaliah (2012) Epidemiology of Foot and Mouth Disease in Cattle in Pahang, Malaysia. Masters by Research thesis, Murdoch University, 2012. https://researchrepository.murdoch.edu.au/id/eprint/10695/.
Pełny tekst źródłaScott, Katherine Anne. "Improved stability of foot-and-mouth disease virus (FMDV) SAT2 capsid". Thesis, University of Pretoria, 2016. http://hdl.handle.net/2263/60130.
Pełny tekst źródłaThe residues at the capsid inter-pentamer interfaces, and their interactions, are important for the infectivity and stability of the virion and mutations adjacent to these interfaces have an effect on the conformational stability of FMDV. However, experimental studies on the relative importance of residues and molecular interactions in viral capsid assembly, disassembly, and/or stability are still very limited, especially for the SAT serotypes of FMDV. This study investigated the effects of potential residues at the pentameric interfaces that are responsible for increased thermostability and potentially improved stability candidates were tested in small (guinea pigs) and large (cattle) animal vaccination trials to understand the role of stabilised antigens on immune responses. The biological variation in biophysical stability in SAT2 viruses in the southern Africa region was investigated to determine if any naturally occurring viruses have greater capsid thermostability. Naturally occurring stable viruses could be used as prospective candidates in vaccine production and therefore potentially result in increased duration of immune responses.
Our first aim was to investigate the role of different amino acid changes at the interface and their effect on capsid stability using models derived by Oxford University. These changes were introduced by mutating the SAT2 ZIM7/83 infectious genome-length clone (pSAT2) to derive mutated chimeric SAT2 viruses. We quantified the stabilizing effects of these mutations by using various stability assays. We established the novel thermofluor shift assay that is able to quantify the capsid stability of viruses. The growth kinetics, antigenicity, genetic stability, pH and salt sensitivity were investigated for each of the genetically engineered viruses (Chapters 2 and 3).
The second aim was to further our understanding on the correlation between improved stability and immune responses by performing small animal (Chapter 2) and large animals trials in cattle (Chapter 4) and comparing stabilised and wild-type antigens. This study for the first time for SAT vaccines, determined differences in IgG1 and IgG2 profiles, interferon gamma (IFN-γ) responses and differences in total and neutralising antibodies of stabilised and wild-type antigens over a six month period in cattle (Chapter 4). Animals were intra-dermolingually challenged with live virus to determine levels of protection the antigens have afforded.
In addition, a third aim will be to better understand the inherent thermostability variation of SAT2 viruses in the Southern African region (Chapter 5) by establishing a protocol for screening field isolates as potential vaccine strains and correlating their stability to amino acid residues at the interface of the 146S particles.
Thesis (PhD)--University of Pretoria, 2016.
Agricultural Research Council
Veterinary Tropical Diseases
PhD
Unrestricted
Birtley, James Robert. "Crystal structure of the 3C protease from foot-and-mouth disease virus". Thesis, Imperial College London, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413578.
Pełny tekst źródłaKnox, Stephen Richard. "Investigating the substrate specificity of foot and mouth disease virus 3C protease". Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.445242.
Pełny tekst źródłaRyan, Eoin Denis. "The Pathogenesis of Foot-and-Mouth Disease in Foetal and Neonatal Lambs". Thesis, Royal Veterinary College (University of London), 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.522721.
Pełny tekst źródłaHingley, P. J. "Problems in modelling responses of animals to foot and mouth disease vaccine". Thesis, University of Reading, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.356751.
Pełny tekst źródłaMiller, Laura Caldwell. "Penetration of the host cell membrane by foot-and-mouth disease virus". Thesis, University of Reading, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366045.
Pełny tekst źródłaStrong, Rebecca Marian. "Modification of protein synthesis initiation by foot-and-mouth disease virus proteases". Thesis, University of Surrey, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.421325.
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