Artykuły w czasopismach na temat „Family-of-origin aggression”
Kliknij ten link, aby zobaczyć inne rodzaje publikacji na ten temat: Family-of-origin aggression.
Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych
Sprawdź 50 najlepszych artykułów w czasopismach naukowych na temat „Family-of-origin aggression”.
Przycisk „Dodaj do bibliografii” jest dostępny obok każdej pracy w bibliografii. Użyj go – a my automatycznie utworzymy odniesienie bibliograficzne do wybranej pracy w stylu cytowania, którego potrzebujesz: APA, MLA, Harvard, Chicago, Vancouver itp.
Możesz również pobrać pełny tekst publikacji naukowej w formacie „.pdf” i przeczytać adnotację do pracy online, jeśli odpowiednie parametry są dostępne w metadanych.
Przeglądaj artykuły w czasopismach z różnych dziedzin i twórz odpowiednie bibliografie.
1
Timmons, Adela C., Sohyun C. Han, Theodora Chaspari, Yehsong Kim, Corey Pettit, Shrikanth Narayanan i Gayla Margolin. "Family-of-origin aggression, dating aggression, and physiological stress reactivity in daily life". Physiology & Behavior 206 (lipiec 2019): 85–92. http://dx.doi.org/10.1016/j.physbeh.2019.03.020.
Pełny tekst źródła
2
Lie, Gwat-Yong, Rebecca Schilit, Judy Bush, Marilyn Montagne i Lynn Reyes. "Lesbians in Currently Aggressive Relationships: How Frequently Do They Report Aggressive Past Relationships?" Violence and Victims 6, nr 2 (styczeń 1991): 121–35. http://dx.doi.org/10.1891/0886-6708.6.2.121.
Pełny tekst źródłaStreszczenie:
Findings are reported from a survey examining the frequency with which women in currently aggressive same-sex relationships also report aggressive past relationships involving female partners, male partners, or members of their family of origin. Particular attention is paid to victims who also used aggression and their perceptions of whether their aggressive behavior was self-defensive or mutually aggressive. Results indicate that about one-fourth of participants had been victims of aggression in current relationships, roughly two-thirds had been victimized by a previous male partner, and almost three-fourths had experienced aggression by a previous female partner. Among those reporting having been both victims and users of aggression, about one-fifth had used aggression in their current relationship, almost one-third used aggression with a previous male partner, and nearly two-thirds had used aggression with a previous female partner. A majority of victims who had also used aggression with a previous male partner characterized this use as self-defense, as compared to only 30% of those who had used aggression with a female partner. Instead, aggression in relationships involving a female partner was most frequently described as mutually aggressive in nature.
3
Murphy, Christopher M., Shannon-Lee Meyer i K. Daniel O’Leary. "Family of Origin Violence and MCMI-II Psychopathology, Among Partner Assaultive Men". Violence and Victims 8, nr 2 (styczeń 1993): 165–76. http://dx.doi.org/10.1891/0886-6708.8.2.165.
Pełny tekst źródłaStreszczenie:
This study examined associations between family of origin violence, self-reports of psychopathology on the MCMI-II, and current spouse abuse among partner assaultive men. Compared to nonviolent men in discordant (n = 24) and well-adjusted (n = 24) relationships, partner assaultive men (n = 24) were significantly more likely to report childhood histories of physical abuse and physical abuse of the mother in the family of origin. The partner assaultive men also reported significantly higher scores on a variety of MCMI-II personality disorder and Axis I disorder scales. When negative affectivity was controlled, however, batterers differed from contrast groups only on scales assessing antisocial and aggressive characteristics. Within the partner assaultive group, a history of severe childhood abuse was associated with higher scores on a variety of MCMI-II personality disorder and Axis I disorder scales, and higher levels of psychological and physical aggression directed toward the current relationship partner. Abuse of the mother in the family of origin among batterers was associated with higher levels of psychological and physical aggression toward the current partner, but not with self-reported psychopathology. The results support prior descriptions of a batterer subgroup with significant trauma histories, more psychological difficulties, and higher abuse levels than other batterers, suggesting continuities in social and emotional development from childhood maltreatment to adult relationship violence.
4
Timmons, Adela C., Reout Arbel i Gayla Margolin. "Daily patterns of stress and conflict in couples: Associations with marital aggression and family-of-origin aggression." Journal of Family Psychology 31, nr 1 (luty 2017): 93–104. http://dx.doi.org/10.1037/fam0000227.
Pełny tekst źródła
5
JULIAN, TERESA W., PATRICK C. McKENRY, STEPHEN M. GAVAZZI i JULIE C. LAW. "Test of Family of Origin Structural Models of Male Verbal and Physical Aggression". Journal of Family Issues 20, nr 3 (maj 1999): 397–423. http://dx.doi.org/10.1177/019251399020003005.
Pełny tekst źródła
6
Arbel, Reout, Aubrey J. Rodriguez i Gayla Margolin. "Cortisol reactions during family conflict discussions: Influences of wives’ and husbands’ exposure to family-of-origin aggression." Psychology of Violence 6, nr 4 (2016): 519–28. http://dx.doi.org/10.1037/a0039715.
Pełny tekst źródła
7
Margolin, Gayla, Elana B. Gordis, Anna Marie Medina i Pamella H. Oliver. "The Co-Occurrence of Husband-to-Wife Aggression, Family-of-Origin Aggression, and Child Abuse Potential in a Community Sample". Journal of Interpersonal Violence 18, nr 4 (kwiecień 2003): 413–40. http://dx.doi.org/10.1177/0886260502250835.
Pełny tekst źródła
8
MacEwen, Karyl E., i Julian Barling. "Multiple stressors, violence in the family of origin, and marital aggression: A longitudinal investigation". Journal of Family Violence 3, nr 1 (marzec 1988): 73–87. http://dx.doi.org/10.1007/bf00994667.
Pełny tekst źródła
9
Karakurt, Günnur, Margaret Keiley i German Posada. "Intimate Relationship Aggression in College Couples: Family-of-Origin Violence, Egalitarian Attitude, Attachment Security". Journal of Family Violence 28, nr 6 (19.06.2013): 561–75. http://dx.doi.org/10.1007/s10896-013-9526-9.
Pełny tekst źródła
10
Fritz, Patti A. Timmons, Amy M. Smith Slep i K. Daniel O'Leary. "Couple-level analysis of the relation between family-of-origin aggression and intimate partner violence." Psychology of Violence 2, nr 2 (2012): 139–53. http://dx.doi.org/10.1037/a0027370.
Pełny tekst źródła
11
Sutton, Tara E., Leslie Gordon Simons, K. A. S. Wickrama i Ted Futris. "The Intergenerational Transmission of Violence: Examining the Mediating Roles of Insecure Attachment and Destructive Disagreement Beliefs". Violence and Victims 29, nr 4 (2014): 670–87. http://dx.doi.org/10.1891/0886-6708.vv-d-13-00007.
Pełny tekst źródłaStreszczenie:
Intimate partner violence has been recognized as a major problem on college campuses and is a source of concern for researchers, clinicians, policymakers, and the general population. Most research has focused on the intergenerational transmission of violence and identifying the intrapersonal mechanisms that enable violence in the family of origin to carry over to adult intimate relationships. This study expands the current literature by examining insecure attachment styles and destructive disagreement beliefs as mediators in the relationship between exposure to hostility or aggression in the family of origin and later experiences of dating aggression. Research questions were addressed with a sample of 1,136 college undergraduates (59% women). In all models, results of structural equation modeling indicated that an insecure attachment style and destructive disagreement beliefs mediated the intergenerational transmission of violence among both men and women. These findings have important implications for future research as well as relationship education programs and preventative interventions.
12
Slawinski, Brooke L., Kelly L. Klump i S. Alexandra Burt. "The etiology of social aggression: a nuclear twin family study". Psychological Medicine 49, nr 1 (2.04.2018): 162–69. http://dx.doi.org/10.1017/s0033291718000697.
Pełny tekst źródłaStreszczenie:
AbstractBackgroundSocial aggression is a form of antisocial behavior in which social relationships and social status are used to damage reputations and inflict emotional harm on others. Despite extensive research examining the prevalence and consequences of social aggression, only a few studies have examined its genetic–environmental etiology, with markedly inconsistent results.MethodWe estimated the etiology of social aggression using the nuclear twin family (NTF) model. Maternal-report, paternal-report, and teacher-report data were collected for twin social aggression (N = 1030 pairs). We also examined the data using the classical twin (CT) model to evaluate whether its strict assumptions may have biased previous heritability estimates.ResultsThe best-fitting NTF model for all informants was the ASFE model, indicating that additive genetic, sibling environmental, familial environmental, and non-shared environmental influences significantly contribute to the etiology of social aggression in middle childhood. However, the best-fitting CT model varied across informants, ranging from AE and ACE to CE. Specific heritability estimates for both NTF and CT models also varied across informants such that teacher reports indicated greater genetic influences and father reports indicated greater shared environmental influences.ConclusionsAlthough the specific NTF parameter estimates varied across informants, social aggression generally emerged as largely additive genetic (A = 0.15–0.77) and sibling environmental (S = 0.42–0.72) in origin. Such findings not only highlight an important role for individual genetic risk in the etiology of social aggression, but also raise important questions regarding the role of the environment.
13
Avakame, Edem F. "Intergenerational Transmission of Violence, Self-Control, and Conjugal Violence: A Comparative Analysis of Physical Violence and Psychological Aggression". Violence and Victims 13, nr 3 (styczeń 1998): 301–16. http://dx.doi.org/10.1891/0886-6708.13.3.301.
Pełny tekst źródłaStreszczenie:
This paper is a sequel to Avakame (1998), a study which sought to determine whether (a) violence in families of origin affects males’ psychological aggression toward wives, and (b) whether the intergenerational transmission effect is solely direct or mediated by Gottfredson and Hirschi’s concept of self-control. The current research extends these questions to females’ psychological aggression as well as males’ and females’ physical violence. The models were estimated using data from the 1975 National Family Violence Survey. Like its precursor, results of the present research suggest that it is useful to (a) distinguish between mothers’ and fathers’ violence and (b) recognize that the intergenerational transmission of violence may be mediated by self-control. Specifically, results suggested that, whether considering physical violence or psychological aggression, fathers’ violence is most likely to exert the direct social learning effect.
14
E.T., Kazdokhova, Nogerova M.T. i Taukenova L.M. "PSYCHOLOGICAL AND PEDAGOGICAL CORRECTION OF AGGRESSIVE BEHAVIOR IN ADOLESCENCE". “Educational bulletin “Consciousness” 23, nr 7 (30.07.2021): 19–26. http://dx.doi.org/10.26787/nydha-2686-6846-2021-23-7-19-26.
Pełny tekst źródłaStreszczenie:
The article is devoted to the problem of prevention and correction of aggressive behavior in adolescents. The increased aggressiveness of adolescent children is one of the most acute problems not only for teachers and psychologists, but also for society as a whole. The growing wave of juvenile delinquency and the increase in the number of children prone to aggressive forms of behavior shed light on the task of studying the psychological conditions that cause these dangerous phenomena. The study of aggressiveness in adolescence is especially important when this characteristic is in the stage of formation and when modern corrective measures can still be taken. The main vectors of development of the modern science of aggressive behavior are identified, the main causes of deviations are determined, and a comparative analysis of works on the prevention of aggressive behavior is carried out. For most children, some form of aggression is typical. However, it is well known that in a certain category of childhood, aggression as a permanent form of behavior not only persists, but also develops, making it a constant human quality. As a result, the adolescent's production potential decreases, his ability to communicate at a high-level decrease, and his personal development is distorted. It has been proved that the key factor in the prevention and correction of aggressive behavior should be, firstly, the family as the primary and most important institution for the formation of identity, and secondly, the pedagogically, psychological and so sociological controlled environment of educational institutions, which serves as a condition for the socialization and personal development of children and adolescents. Important questions remain open regarding the nature and origin of the aggression. The urgency of this problem determined the formulation of the topic of our research «Psychological and pedagogical correction of aggressive behavior in adolescence”.
15
Martin Ramirez, J., i Camilla Pagani. "Editorial: Towards a Better Understanding of Aggression and Other Related Concepts". Open Psychology Journal 8, nr 1 (30.01.2015): 1–2. http://dx.doi.org/10.2174/1874350101508010001.
Pełny tekst źródłaStreszczenie:
This special issue entitled “Towards a better understanding of aggression and other related concepts” is a product of the XXXVII CICA International Conference co-organized by two Polish universities: Kazimierz Wielki University of Bydgoszcz and the University of Zielona Góra. It took place from the 22 to the 25 June, 2014 and was attended by about 100 participants from 16 countries [1]. The aim of the Conference was to study the phenomena of aggression and conflict resolution using a comprehensive, integrated and interdisciplinary approach which takes into account both biological and psycho-socio-cultural factors. Several communications dealing with emotions, including anger and fear, and others with behaviors such as aggression, violence and terrorism, have been selected for this issue. A Southafrican practitioner, Tina Lindhard, specialized in transpersonal psychology, suggests that maybe it is time we start studying emotions including anger and fear from "the inside out" by including phenomenology as a method to throw more light on how we experience these states in or through our bodies. Furthermore, she presents the "Living Matrix" model, which owes its origin to Quantum Mechanics and Electronic Biology, as a new complementary way of understanding how the living organism functions [2]. The Italian scholar Dr. Pagani stresses the complexity of violence, presented as a macrosystem of networks and of agents linked and interacting at different interconnected levels. She points out to the difficulty of defining violence, referring it not only to the explorations of the connections between systems taken from different research fields, but also to the theoretical premises and to the aims of the research. She argues that this “holistic” approach could allow a deeper understanding of violence and could lead towards more innovative and effective solutions to the problem of violence itself [3]. Dr. Ramirez, who has dedicated several decades of his research to the analysis of the justification of aggression from a cross-cultural approach across four continents, evaluates the applicability of a specific test (CAMA) in a new cultural context, assessing the structural equivalence of the data obtained in two different German age cohorts with the data previously investigated across the other cultures. Some adaptations concerning the assessment and theoretical models of the justification of aggressive actions in the German cultural context are being discussed [4]. Two academic colleagues from the University of Zielona Góra, Dr. Farnicka & Dr. Grzegorzewska, focus on some more practical aspects of aggression research, if we may say that, leading towards its prevention or therapy in children and adolescents. These Polish psychologists identify and analyse the family determinants for undertaking the aggressor or victim role. The results of their study reveal a number of determinants for people involved in perpetration or victimization, such as the type of relationship with parents (secure or insecure pattern), personal experience of being in the victim or aggressor role, and the level of hostility [5]. Finally, the first president of the Society for Terrorism Research, Dr. LoCicero, recounts some concerns raised by American psychologists, both earlier, in the years following September 11, 2001 (9/11), and more recent changes in the US policy, leading towards the risk for the USA of becoming a police state. According to her paper, engaging in open discussion about the failings of the American policy, the sometimes legitimate grievances of terrorist groups, and the draw of violence as a solution, is likely to put sincere and innocent adults at risk of becoming targets of intensive surveillance and suspicion [6]. It is thus clear that the discussion on aggression and other related concepts is here carried out from various scientific perspectives, which include traditional experimental psychology with a special focus on the role of family relationships and cultural factors, social and political psychology with a special focus on the role of State policies, and other theoretical perspectives which try to integrate their psychological framework with contributions from western and eastern philosophy, the neurosciences, biology, quantum physics, and complexity theory.
16
Sluijs, Inke van der, Peter D. Dijkstra, Charlotte M. Lindeyer, Bertanne Visser, Alan M. Smith, Ton G. G. Groothuis, Jacques J. M. van Alphen i Ole Seehausen. "A test of genetic association among male nuptial coloration, female mating preference, and male aggression bias within a polymorphic population of cichlid fish". Current Zoology 59, nr 2 (1.04.2013): 221–29. http://dx.doi.org/10.1093/czoolo/59.2.221.
Pełny tekst źródłaStreszczenie:
Abstract Both interand intrasexual selection have been implicated in the origin and maintenance of species-rich taxa with diverse sexual traits. Simultaneous disruptive selection by female mate choice and male-male competition can, in theory, lead to speciation without geographical isolation if both act on the same male trait. Female mate choice can generate discontinuities in gene flow, while male-male competition can generate negative frequency-dependent selection stabilizing the male trait polymorphism. Speciation may be facilitated when mating preference and/or aggression bias are physically linked to the trait they operate on. We tested for genetic associations among female mating preference, male aggression bias and male coloration in the Lake Victoria cichlid Pundamilia. We crossed females from a phenotypically variable population with males from both extreme ends of the phenotype distribution in the same population (blue or red). Male offspring of a red sire were significantly redder than males of a blue sire, indicating that intra-population variation in male coloration is heritable. We tested mating preferences of female offspring and aggression biases of male offspring using binary choice tests. There was no evidence for associations at the family level between female mating preferences and coloration of sires, but dam identity had a significant effect on female mate preference. Sons of the red sire directed significantly more aggression to red than blue males, whereas sons of the blue sire did not show any bias. There was a positive correlation among individuals between male aggression bias and body coloration, possibly due to pleiotropy or physical linkage, which could facilitate the maintenance of color polymorphism.
17
Kaufman-Parks, Angela M., Alfred DeMaris, Peggy C. Giordano, Wendy D. Manning i Monica A. Longmore. "Familial Effects on Intimate Partner Violence Perpetration Across Adolescence and Young Adulthood". Journal of Family Issues 39, nr 7 (9.10.2017): 1933–61. http://dx.doi.org/10.1177/0192513x17734586.
Pełny tekst źródłaStreszczenie:
Research suggests violence in the family-of-origin is a consistent predictor of later intimate partner violence (IPV). However, prior empirical studies have also demonstrated that exposure to violence does not lead deterministically to violent behaviors in young adulthood. Given that family context entails more than simply the presence or absence of abuse, additional aspects of family life warrant examination. One such aspect is the quality of the parent–child relationship. Using five waves of data from the Toledo Adolescent Relationships Study ( N = 950 respondents, 443 males and 507 females), the present study examined both main and interactive effects of parent–child physical aggression (PCPA) and parent–child relationship quality (PCRQ) in predicting adolescents’ and young adults’ IPV perpetration. Results indicated that both PCPA and PCRQ were key independent predictors of individuals’ IPV perpetration, but did not interact to produce cumulatively different risk. Important interactions between PCPA and gender, and PCRQ and age were also found.
18
Chernyak, Elena, Ryan Ceresola i Morgan Herrold. "From past to present: children’s exposure of intimate partner violence and subsequent experience of IPV in adulthood among women". Journal of Gender-Based Violence 4, nr 2 (1.06.2020): 259–78. http://dx.doi.org/10.1332/239868020x15893856098343.
Pełny tekst źródłaStreszczenie:
The objective of this research is to analyse the prevalence of physical intimate partner violence (IPV) in ten developing countries in four regions as identified by the Demographics and Health Survey (DHS): Sub-Saharan Africa with Mali and Nigeria; North Africa/West Asia with Egypt and Jordan; South and Southeast Asia with Cambodia, Pakistan and the Philippines; and Latin America and the Caribbean with Haiti, the Dominican Republic and Peru. These countries are all tested with one primary research question: whether witnessing physical IPV in family-of-origin is associated with women’s experience of physical IPV in adulthood. Past research has shown reason to believe witnessing parental violence is a significant risk factor in IPV in many nations, but the influence of IPV in these developing countries has not been examined.The results indicate that having witnessed physical IPV in one’s family-of-origin significantly increases the likelihood of experiencing later physical abuse, for respondents in all countries. By controlling for other factors, this finding provides robust support for the intergenerational transmission of violence theory, which explains the link between interparental aggression and physical IPV in subsequent relationships as a result of learned models of behaviour observed in childhood. Implications of this research for developing countries are also discussed.
19
West, Carolyn M. "Partner Abuse in Ethnic Minority and Gay, Lesbian, Bisexual, and Transgender Populations". Partner Abuse 3, nr 3 (2012): 336–57. http://dx.doi.org/10.1891/1946-6560.3.3.336.
Pełny tekst źródłaStreszczenie:
This review seeks to synthesize the current state of knowledge regarding gender differences in rates of physical and psychological intimate partner violence (IPV) prevalence among the four largest racial/ethnic groups in the United States, compares rates of physical and psychological IPV between sexual minorities and heterosexuals and among subgroups of sexual minorities (gay men, lesbians, bisexuals), and summarizes correlates and risk factors that are associated with rates of IPV in both ethnic and sexual minorities.A systematic search of the published literature in the past 40 years using various search engines (e.g., PubMed, PsycINFO, and Web of Science) was conducted. The review identified 55 studies that met criteria. Few gender differences in rates of physical and psychological aggression were found among African American, Hispanic American, Asian American, and Native American men and women. Psychological aggression was most frequently reported. Bidirectional violence, which primarily took the form of minor aggression, was the most frequently reported form of physical violence. When unidirectional aggression was assessed, it was more likely to be female perpetrated, particularly among African Americans. These gender patterns were consistent across general population, student, and community studies. Respondents who reported a history of same-sex cohabitation and those who identified as sexual minorities reported higher rates of IPV than those who reported only a history of opposite-sex cohabitation and those who identified as heterosexual.Regarding sexual minority subgroup differences, bisexuals appeared to be at a greater risk of IPV, and victimization among transgendered individuals has largely been neglected in the literature. Substance abuse and use, marginalized socioeconomic status in the form of family and neighborhood poverty, and exposure to violence during childhood as a witness or victim of violence in the family of origin were consistently linked to elevated rates of IPV. Associations also were found between level of acculturation and minority stress in the form of internalized homophobia and frequency of discrimination based on sexual orientation. However, the complex association among these variables was less clear across racial groups and sexual orientation. Research limitations and future research directions are discussed.
20
Kaplan, Kalman J. "The Death of Jesus, Christian Salvation, and Easter-Week Atrocities against Jews: A Suicidological Approach". OMEGA - Journal of Death and Dying 36, nr 1 (1.01.1997): 63–75. http://dx.doi.org/10.2190/e40c-6dew-h7m8-exkl.
Pełny tekst źródłaStreszczenie:
A question ignored by suicidologists is the degree to which major Christian theologians have stressed that Jesus gave up his life voluntarily as an act of salvation for mankind and that it was not taken by another. Indeed His death, in Durkheim's terms, is an “altruistic suicide” and is offered as a standard of love for others. Nevertheless, the Jewish people have been historically blamed for His death with many anti-Jewish persecutions occurring coincidentally with the Christian Holy Week. The believing Christian can be seen as a survivor of “altruistic suicide,” certain New Testament passages as a suicide note, Easter Week as the anniversary date of Jesus' death, and anti-Jewish persecutions during this period as displacement of survivor guilt into aggression toward Jesus' family of origin.
21
Buicu, G. E., M. Gabos Grecu, A. Salcudean, I. Gabos Grecu, C. Marinescu, A. Nirestean, S. Turliuc, V. Hadareanu i I. Udristoiu. "Evaluation of elder physical abuse". European Psychiatry 41, S1 (kwiecień 2017): S583—S584. http://dx.doi.org/10.1016/j.eurpsy.2017.01.880.
Pełny tekst źródłaStreszczenie:
BackgroundIn the society we belong to, elders are the target of abuse which is many times generated by the social cultural tendency which promotes different expressions in terms of age, a tendency which also measures capacity in terms of age.ObjectiveTo evaluate elder physical abuse – cases reviewed at the Forensic Institute, Tirgu Mures County, Romania.MethodsAn experimental design was used, focusing on elder physical abuse cases involving victims aged 65 or older, who requested a forensic certificate. All cases were reviewed at the Forensic Institute Tg. Mures, Mures County, Romania between 1st of Jan–31st Dec 2014. Variables included: age, gender, environmental origin, physical abuse, sexual abuse, relationship with the perpetrator (relative, known person/neighbor, unknown person, husband/wife), the required number of days of hospitalization, victim previous psychiatric diagnosis, aggressor previous psychiatric diagnosis.ResultsA total of 5252 forensic medical certificates were issued at request by the Forensic Institute of Tg Mures. One hundred and twenty (2.28%) were related to acknowledgement of the aggression of an elderly peIntroductionrson (≥65 years, with an average age of 69.89 years CI: 68.8903–70.8930). The majority of subjects were males (65%), of rural origin (64.17%). The same address as the aggressor's was identified in most of the cases (41.66%). 35.83% were hurt by neighbours/acquaintances, 22.5% were attacked by strangers.ConclusionWe are aware of that an elder abuse appears to occur most often in domestic home situations, men from rural, more often than women, are involved that victims and may be perpetrated by adult family members, or other persons.Disclosure of interestThe authors have not supplied their declaration of competing interest.
22
Shcherbak, Vitalii. "1638 Cossacks Register as Historical Source". Kyiv Historical Studies 13, nr 2 (21.12.2021): 131–36. http://dx.doi.org/10.28925/2524-0757.2021.217.
Pełny tekst źródłaStreszczenie:
The article gives the analysis of the register of cossacks in 1638 as one of the Ukrainian historical sources which contain data about the structure and special ethnic origin of the Zaporozhian Host before the beginning Liberation war in the middle of the 17th century. Attention is focused on the fundamentals of register formation based on the territorial principle which was initiated by the Kurukovo Agreement. The reasons for the absence of key positions such as a quartermaster (obozny), a judge (suddia) and a chancellor (pysar) in the registered army are being clarified. Information about the amount of payment for the service of Cossack officer is also valuable. The continuity of Cossack family traditions was traced, in particular through participation in the resistance to Turkish aggression and armed uprisings.
23
Khouadja, S., S. Younes, S. Chatti, R. Ben Soussia, L. Zarrouk i M. Nasr. "The acting out in patients with Schizophrenia examined in a forensic psychiatric assessment". European Psychiatry 41, S1 (kwiecień 2017): S591. http://dx.doi.org/10.1016/j.eurpsy.2017.01.906.
Pełny tekst źródłaStreszczenie:
IntroductionMany studies have shown that schizophrenic patients are responsible for the highest rates of violence among all the mentally ill patients.Aims of the studyDescribe the socio-demographic and clinical characteristics of patients with schizophrenia examined in a forensic psychiatric assessment and identify the risk factors of violence in these patients.MethodologyA retrospective study carried out in the psychiatric department of university hospital of Mahdia during fifteen years involving 40 patients with schizophrenia examined in a forensic psychiatric assessment following a forensic act. These patients were compared to a population of 40 patients followed in the same establishment for the same disease and without criminal record.ResultsAge average of 36.08 years, male (95%), rural origin (65%), primary level education (47.5%), single (65%), unemployed (65%) and average socio-economic level (65%). Personal psychiatric history (87.5%), personality disorder (12.5%), judiciary history (12.5%) and substance abuse (57.5%). Subtypes of schizophrenia: undifferentiated (52.5%) and paranoid (30%). They have committed serious physical assaults (55%) and aggression against property (27.5%). The victim was mostly a family member (40%), under the influence of toxic (22%), driven by delusions of persecution (61%), with hallucinatory mechanism (55%). The psychiatric expert has concluded an abolition of discernment in 77.5% of cases. Risk factors of acting out were: rural origin, alcohol and psychoactive substances use, productive forms of schizophrenia, poor adherence and irregular monitoring.ConclusionThe knowledge of risk factors improves the management and allows us better prevention of violence among our patients.Disclosure of interestThe authors have not supplied their declaration of competing interest.
24
Володіна, О. О., i Т. М. Малиновська. "Prevention of domestic violence against the elderly". Law and Safety 77, nr 2 (24.06.2020): 81–85. http://dx.doi.org/10.32631/pb.2020.2.11.
Pełny tekst źródłaStreszczenie:
Domestic violence is one of the most common forms of human rights violations. Illegal actions against a family member are in most cases accompanied by acts of aggression, humiliation and abuse. Such actions by the abuser lead to a negative physical, mental and social health of the victim or several members of the family. As a rule, women, children and the elderly suffer the most from domestic violence.
The state is the main actor in combating violence, and public authorities should help to create the environment of non-violence by taking the necessary measures and creating the system of protection of victims, punishment of perpetrators and prevention of violence.
Despite the existing regulatory provision in the field of combating and protecting the rights and interests of victims of domestic violence, as well as a wide range of scientific papers focused on various aspects in this area, the problem of domestic violence remains relevant and needs theoretical clarification and justification.
The purpose of the article is to determine the causes of the origin of domestic violence against the elderly, to analyze the forms for the commission of violence against persons of this category, to focus on the wide scale of this issue, preventive measures and the need to create an information base (statistics) of victims. The introduction of an information database (statistics accounting) of victims suffered from domestic violence will ensure unimpeded access for employees of the National Police, territorial centers of social services and medical institutions to information about the victims. Inquiries and reports will make it possible to quickly and efficiently update the information and keep differentiated statistical records of such persons.
25
Toporkov, Andrei L. "Verbal Charms Against Authorities and Judges in Seventeenth- and Eighteenth-Century Russia". Russian History 40, nr 3-4 (2013): 532–39. http://dx.doi.org/10.1163/18763316-04004016.
Pełny tekst źródłaStreszczenie:
In the 17-18th century Russian manuscript tradition there were no fewer than nine collections (sborniki) consisting of verbal charms that are exclusively or primarily addressed to social issues, and meant to have an effect on judges, military commanders, landowners, bureaucrats, and, not least, on the tsar himself and members of the royal family. The magical purpose of these verbal charms was to have an influence on authorities and judges, to alter the way they felt and their will, their mood and spiritual condition. The tradition of incantations if seen as a whole did not force a person to take this or that specific attitude toward the authorities, but rather offered the possibility of choice either to consider the object of the charm as an implacable foe, deserving of annihilation (if only symbolic), or as someone more positive, from whom love is coaxed. The first type led to the use of “bestial” imagery that was of pagan origin; these charms allowed for the sublimation of aggression and the feeling of social inferiority, channeling these into the creation of fantasy images. The second type makes use of Christian subjects and symbols. Turning to folkloric and then in turn to Christian images, a person would not necessarily contradict himself or play the hypocrite, but rather attempt to resolve on a symbolic plane those practical conflicts that occupied him in real life.
26
Telbizova, Tatyana, Ivan Aleksandrov i Mariana Arnaoudova. "DYNAMICS OF PSYCHIATRIC SYMPTOMS IN CUSHING’S SYNDROME". Journal of IMAB - Annual Proceeding (Scientific Papers) 26, nr 4 (19.11.2020): 3443–48. http://dx.doi.org/10.5272/jimab.2020264.3443.
Pełny tekst źródłaStreszczenie:
Cushing’s syndrome may present with various psychiatric disorders which can lead to a misdiagnosis at the beginning, deterioration of the course of the disease and life-threatening complications. The most common psychiatric disorder is atypical depression. During the initial stages of the disease, the somatic symptoms of Cushing’s syndrome can be subtle, difficult to identify, especially when the psychiatric symptoms are dominant. Objective: The aim of the present article is to report a case of a 24-year-old woman with a Cushing’s syndrome, caused by the adrenal adenoma. The onset of the disease is a suicidal attempt. Family history is significant for psychiatry disorder. The belated diagnosis led to somatic and psychiatry complications of the disease – sepsis and persisting high suicidal risk. The dynamic change in the patient’s mental state – from a severe depressive episode with atypical symptoms to psychosis with single catatonic symptoms – correlated well with the gradual increase of the plasma cortisol levels. The antidepressant and subsequent antipsychotic medication turned out to be ineffective. The surgical treatment, followed by a normalization of the cortisol levels was a key to the successful outcome and the reduction of self-aggression risk. Conclusion: The early diagnosis and timely treatment of Cushing’s syndrome decrease the risk of multiple complications. The shift from atypical depression to psychosis with catatonic symptoms correlates with the worsening of the hormonal imbalance. The signs of atypical depression in Cushing's syndrome, resistant to the antidepressant medication, could be considered as relatively specific symptoms, guiding specialists to its somatogenic origin for the proper diagnosis.
27
Yendell, Alexander, Vera Clemens, Julia Schuler i Oliver Decker. "What makes a violent mind? The interplay of parental rearing, dark triad personality traits and propensity for violence in a sample of German adolescents". PLOS ONE 17, nr 6 (22.06.2022): e0268992. http://dx.doi.org/10.1371/journal.pone.0268992.
Pełny tekst źródłaStreszczenie:
Machiavellianism, narcissism and psychopathy are socially aversive personality traits that are strongly linked to the propensity of violence. A central determinate of aggression and violence is parental rearing. Interestingly, while the origin of the development of Dark Triad is not yet entirely understood, next to genetic and environmental factors, literature points towards an influence of parenting styles to the development of dark traits. Therefore, in a sample of 1366 9th grade students (mean age 14.89,), we assessed the interplay between parental rearing, dark triad traits, observation of violence among peers and their propensity for violence. The sample has a good representativeness on school types. Results reveal a positive association between the experience of parental rejection by both parents and punishment as well as parental control and overprotection and Machiavellianism, narcissism and psychopathy. Parental emotional warmth was associated negatively with Machiavellianism and psychopathy while no significant association with narcissism was seen. In a path model, parental rearing, dark triad traits and observation of violence among peers significantly contributed to the propensity of violence. However, differences between the experienced parenting behaviour of mothers and fathers should be noted. Both rejection and overly harsh punishments by fathers and emotional warmth by mothers have no significant influence on the dark triad. It is interesting that the effects regarding maternal parenting behaviour are stronger overall than the effects regarding paternal parenting behaviour. These results underline the importance of parental rearing on the development of Machiavellianism, narcissism and psychopathy and suggest a significant role of parental rearing and the dark triad traits on propensity for violence in adolescents. Parenting trainings and family interventions may be a promising starting point to prevent antisocial behavior linked to the dark triad and to prevent violent behavior in future generations
28
Lyubinska, Lyudmila, i Mykola Маtvieiev. "Invasive species in the flora and fauna of Podilski Tovtry National Nature Park (Ukraine)". GEO&BIO 2021, nr 20 (17.02.2021): 70–78. http://dx.doi.org/10.15407/gb2009.
Pełny tekst źródłaStreszczenie:
The territory of Podilski Tovtry National Natural Park covers an area of 261 315 ha, 72 % of which are cultivated lands that facilitated the expansion of 335 adventive species. Research on invasive plant and animal species was carried out during field surveys in 1996–2019. More than 220 geobotanical descriptions were compiled applying the Brown-Blanque method. In this territory, 26 species display distinct aggression and are referred to as invasive, which belong to 15 families of the class Magnoliopsida and division Magnoliophyta. By origin, Northern American species prevail (15 species) followed by Asian (6) and European (5) species. By life form, annual herbal plants (therophytes) and trees predominate. Тherophytes mainly represent the family Asteraceae. The studies of the phytocenosis showed that the invasive species are part of 19 vegetation classes. The invasive species settled in 14 natural communities and they grow in 10 rare (singular) aggregations. To reduce the impact of invasive species on rare habitats and communities it is necessary to take measures to restore the natural vegetation cover. In the territory of Podilski Tovtry National Nature Park, 7 species of vertebrate animals are considered invasive, the naturalisation of which threatens and has negative influence on the local fauna. Another 6 species of birds and mammals, due to natural range expansion and anthropogenic changes of abiotic environmental factors, settled in urban landscapes and were introduced by means of synanthropisation; they can be considered as close invaders. Motacilla citreola occurs in wet meadows and has an unstable abundance, thus it belongs to propulsive species. Another 11 bird species appear in the surveyed territory during the autumn and winter periods or in separate years. Their invasiveness is possible due to abundance fluctuations during migration and changes in their migration routes because of the influence of trophic factors.
29
Polish, Ariel, Maxwell T. Vergo i Mark Agulnik. "Management of Neuroendocrine Tumors of Unknown Origin". Journal of the National Comprehensive Cancer Network 9, nr 12 (grudzień 2011): 1397–402. http://dx.doi.org/10.6004/jnccn.2011.0118.
Pełny tekst źródłaStreszczenie:
Neuroendocrine tumors (NETs) of unknown origin account for more than 10% of all NETs. Most of these tumors are poorly differentiated and, thus, very aggressive. Establishing the location of the primary tumor can be challenging. Workup of these NETs of unknown origin includes a thorough family history, immunohistochemistry, imaging, and OctreoScan. If the location of the primary malignancy is not determined, treatment is often initiated based on the grade and level of differentiation of the tumor, with well- and moderately differentiated tumors treated as carcinoid tumors, whereas poorly differentiated tumors are treated similarly to small cell tumors. Therapy is chosen based on symptoms and with the goal of debulking tumor when feasible and safe.
30
Conger, Rand D., Monica J. Martin, April S. Masarik, Keith F. Widaman i M. Brent Donnellan. "Social and economic antecedents and consequences of adolescent aggressive personality: Predictions from the interactionist model". Development and Psychopathology 27, nr 4pt1 (6.10.2015): 1111–27. http://dx.doi.org/10.1017/s0954579415000711.
Pełny tekst źródłaStreszczenie:
AbstractThe present study examined the development of a cohort of 279 early adolescents (52% female) from 1990 to 2005. Guided by the interactionist model of socioeconomic status and human development, we proposed that parent aggressive personality, economic circumstances, interparental conflict, and parenting characteristics would affect the development of adolescent aggressive personality traits. In turn, we hypothesized that adolescent aggressiveness would have a negative influence on adolescent functioning as an adult in terms of economic success, personality development, and close relationships 11 years later. Findings were generally supportive of the interactionist model proposition that social and economic difficulties in the family of origin intensify risk for adolescent aggressive personality (the social causation hypothesis) and that this personality trait impairs successful transition to adult roles (the social selection hypothesis) in a transactional process over time and generations. These results underscore how early development leads to child influences that appear to directly hamper the successful transition to adult roles (statistical main effects) and also amplify the negative impact of dysfunctional family systems on the transition to adulthood (statistical interaction effects). The findings suggest several possible points of intervention that might help to disrupt this negative developmental sequence of events.
31
Kadagad, Poornima, Meenaxi V. Umarani i Pascal X. Pinto. "Primitive Neuroectodermal Tumor of Maxilla: A Rare Case". World Journal of Dentistry 2, nr 3 (2011): 281–83. http://dx.doi.org/10.5005/jp-journals-10015-1098.
Pełny tekst źródłaStreszczenie:
ABSTRACT Primitive neuroectodermal tumor (PNET) is an aggressive round cell malignancy of presumed neural crest origin belonging to Ewing's sarcoma family of tumors. Peripheral PNET is less common in head and neck region and only eight cases of primary PNET of maxilla have been reported. We report a case of 3-year-old boy diagnosed with PNET of maxilla based on detailed radiologic, histopathologic, and immunohistochemical studies. Though the imaging features of PNET are nonspecific and definitive diagnosis is only by immunohistochemistry, PNET should be included in the differential diagnoses of fast growing soft tissue tumors of children and young adolescents. We emphasize the need for its early diagnosis and prompt management owing to its aggressive nature and high mortality rate.
32
Hron, Alexander J., i Atsushi Asakura. "An Examination of the Role of Transcriptional and Posttranscriptional Regulation in Rhabdomyosarcoma". Stem Cells International 2017 (2017): 1–10. http://dx.doi.org/10.1155/2017/2480375.
Pełny tekst źródłaStreszczenie:
Rhabdomyosarcoma (RMS) is an aggressive family of soft tissue tumors that most commonly manifests in children. RMS variants express several skeletal muscle markers, suggesting myogenic stem or progenitor cell origin of RMS. In this review, the roles of both recently identified and well-established microRNAs in RMS are discussed and summarized in a succinct, tabulated format. Additionally, the subtypes of RMS are reviewed along with the involvement of basic helix-loop-helix (bHLH) proteins, Pax proteins, and microRNAs in normal and pathologic myogenesis. Finally, the current and potential future treatment options for RMS are outlined.
33
Singh, Nidhi N., V. Gupta i Ashutosh K. Singh. "Ewing’s sarcoma of fifth metacarpal with lung metastasis in a child: an unusual presentation". International Journal of Contemporary Pediatrics 4, nr 5 (23.08.2017): 1903. http://dx.doi.org/10.18203/2349-3291.ijcp20173808.
Pełny tekst źródłaStreszczenie:
Ewing’s sarcoma is the second most common bone tumour second only to osteosarcoma which represents a family of malignancies of neuroendothelial origin, which are highly aggressive and poorly differentiated. The most frequent sites involved are shaft of long bones such as femur, tibia and flat bones such as pelvis and vertebra. Ewing’s sarcoma of small bones of hands is very rare and distant metastasis with hands as the primary is even rarer. Here we describe the course of a 11-year-old male who presented with ewings sarcoma of fifth metacarpal who presented with lung metastasis without local recurrence of the disease after primary surgery and later succumbed to his illness.
34
Krill, Michael K., Alexandra E. Fogarty i Sindhu Jacob. "A 71-year-old man with a rare rhabdoid brain tumour: using a multidisciplinary medical and rehabilitative model of care". BMJ Case Reports 13, nr 6 (czerwiec 2020): e231924. http://dx.doi.org/10.1136/bcr-2019-231924.
Pełny tekst źródłaStreszczenie:
Atypical rhabdoid tumours (AT/RTs) of pineal origin are rare in adults with rapid progression and poor prognosis. We present the case of a 71-year-old man with confusion and memory loss who was diagnosed with a pineal AT/RT after genetic analysis. Due to his limited functional capacity and goal to return home with family, a multidisciplinary care approach was essential for coordination of medical management, radiation treatment and acute inpatient rehabilitation. After diagnosis and rehabilitation, his functional ability improved allowing him to tolerate cranial irradiation, initiate systemic chemotherapy and eventually returned home for a brief period with an improved quality of life. His progress was temporary due to rapid progression of the tumour. He required additional aggressive oncological treatment and was admitted for subsequent inpatient rehabilitation before opting for hospice care. This case underscores the importance of a multidisciplinary approach to cancer treatment in a patient with a rare and aggressive brain tumour, while respecting the individual goals of patients and their families.
35
Ueki, Arisa, Kokichi Sugano, Kumiko Misu, Eriko Aimono, Kohei Nakamura, Shigeki Tanishima, Nobuyuki Tanaka i in. "Germline Whole-Gene Deletion of FH Diagnosed from Tumor Profiling". International Journal of Molecular Sciences 22, nr 15 (26.07.2021): 7962. http://dx.doi.org/10.3390/ijms22157962.
Pełny tekst źródłaStreszczenie:
Hereditary leiomyomatosis and renal cell carcinoma (HL (RCC)) entails cutaneous and uterine leiomyomatosis with aggressive type 2 papillary RCC-like histology. HLRCC is caused by pathogenic variants in the FH gene, which encodes fumarate hydratase (FH). Here, we describe an episode of young-onset RCC caused by a genomic FH deletion that was diagnosed via clinical sequencing. A 35-year-old woman was diagnosed with RCC and multiple metastases: histopathological analyses supported a diagnosis of FH-deficient RCC. Although the patient had neither skin tumors nor a family history of HLRCC, an aggressive clinical course at her age and pathological diagnosis of FH-deficient RCC suggested a germline FH variant. After counseling, the patient provided written informed consent for germline genetic testing. She was simultaneously subjected to paired tumor profiling tests targeting the exome to identify a therapeutic target. Although conventional germline sequencing did not detect FH variants, exome sequencing revealed a heterozygous germline FH deletion. As such, paired tumor profiling, not conventional sequencing, was required to identify this genetic deletion. RCC caused by a germline FH deletion has hitherto not been described in Japan, and the FH deletion detected in this patient was presumed to be of maternal European origin. Although the genotype-phenotype correlation in HLRCC-related tumors is unclear, the patient’s family was advised to undergo genetic counseling to consider additional RCC screening.
36
Merskey, Helen S., i G. T. Swart. "Family Background and Physical Health of Adolescents Admitted to an Inpatient Psychiatric Unit, I: Principal Caregivers". Canadian Journal of Psychiatry 34, nr 2 (marzec 1989): 79–83. http://dx.doi.org/10.1177/070674378903400201.
Pełny tekst źródłaStreszczenie:
A retrospective chart review of 100 consecutive adolescents discharged from a provincial psychiatric hospital adolescent unit was conducted. At the time of admission, eighty-four percent no longer lived with one or both of the biological parents. The children remained with the mother more often than with the father. However, boys who had lost their principal male caregiver more often acquired a new one, compared with girls. The latter tended to remain more in a single-mother home. Thirty jour patients were no longer in the care of either parent at admission. Seventy jour had a conduct disorder. Members of this group were more likely to have lost one or both parents. Recent loss of a parent seemed to be related to a combined diagnosis of depression and conduct disorder. Parental loss was not prominent among one class of the patients with conduct disorder — those with under-socialized aggressive disorders. The latter were often still in their intact biological family of origin, and in four instances they presented serious cases of aggressive actions in the absence of any history of parental deprivation.
37
Bartholow, Tanner, i Anil Parwani. "Renal Primitive Neuroectodermal Tumors". Archives of Pathology & Laboratory Medicine 136, nr 6 (1.06.2012): 686–90. http://dx.doi.org/10.5858/arpa.2011-0104-rs.
Pełny tekst źródłaStreszczenie:
Primitive neuroectodermal tumors exist as a part of the Ewing sarcoma/primitive neuroectodermal tumor family. These tumors most commonly arise in the chest wall and paraspinal regions; cases with a renal origin are rare entities, but have become increasingly reported in recent years. Although such cases occur across a wide age distribution, the average age for a patient with a renal primitive neuroectodermal tumor is the mid- to late 20s, with both males and females susceptible. Histologically, these tumors are characterized by pseudorosettes. Immunohistochemically, CD99 is an important diagnostic marker. Clinically, these are aggressive tumors, with an average 5-year disease-free survival rate of only 45% to 55%. Given that renal primitive neuroectodermal tumor bears many similarities to other renal tumors, it is important to review the histologic features, immunostaining profile, and genetic abnormalities that can be used for its correct diagnosis.
38
Zhou, Ping, Norman B. Levy, Haiyi Xie, Liping Qian, Chi-Yu Gregory Lee, Randy D. Gascoyne i Ruth W. Craig. "MCL1 transgenic mice exhibit a high incidence of B-cell lymphoma manifested as a spectrum of histologic subtypes". Blood 97, nr 12 (15.06.2001): 3902–9. http://dx.doi.org/10.1182/blood.v97.12.3902.
Pełny tekst źródłaStreszczenie:
Viability-promoting genes such as BCL2 play an important role in human cancer but do not directly cause aggressive tumors. BCL2 transgenic mice develop lymphoma at low frequency, hindering studies of tumorigenesis and its inhibition in the presence of such gene products. MCL1 is a member of theBCL2 family that is highly regulated endogenously and that promotes cell viability and immortalization when introduced exogenously. Mice expressing an MCL1 transgene in hematolymphoid tissues have now been monitored for an extended period and were found to develop lymphoma with long latency and at high probability (more than 85% over 2 years). In most cases, the disease was widely disseminated and of clonal B-cell origin. A variety of histologic subtypes were seen, prominently follicular lymphoma and diffuse large-cell lymphoma. MCL1 thus sets the stage for the development of lymphoma as does BCL2, disease occurring with high probability and recapitulating a spectrum of subtypes as seen in human patients. These findings with the transgene underscore the importance of the normal, highly regulated pattern of MCL1expression, in addition to providing a model for studying tumorigenesis and its inhibition in the presence of a viability promotingBCL2 family member.
39
Martino, Giovanni, Magda Zanelli, Andrea Marra, Martina Quintini, Maurizio Zizzo, Stefano Ascani, Maria Paola Martelli i Brunangelo Falini. "Flower cells of tropical descent: a challenging case of adult T-cell leukemia/lymphoma". Tumori Journal 105, nr 6 (1.05.2019): NP38—NP42. http://dx.doi.org/10.1177/0300891619847756.
Pełny tekst źródłaStreszczenie:
Background: Adult T-cell leukemia/lymphoma (ATLL) is an aggressive disease associated with human T-lymphotropic virus type 1 infection, with a very high prevalence in tropical areas but exceptionally rare in Europe and Western countries. Case presentation: We describe a challenging case of ATLL in a young male patient with Brazilian origin and adopted as a child by an Italian family, presenting to our clinic with atypical T-lymphocytosis and life-threatening lung infections. Conclusions: Diagnosis of ATLL outside of endemic areas can be difficult, requiring a high index of clinical suspicion with careful evaluation of the patient’s clinical history. Prognosis is affected by disease stage at presentation and degree of immunosuppression. Few effective treatments are available, although new molecular insights have highlighted the role of host immune response and immune checkpoint blockade inhibitors, given the overexpression of PD-L1 on lymphoma cells and on microenvironment cells.
40
El-Sharkawi, Salah. "Angiosarcoma of the head and neck". Journal of Laryngology & Otology 111, nr 2 (luty 1997): 175–76. http://dx.doi.org/10.1017/s0022215100136771.
Pełny tekst źródłaStreszczenie:
AbstractAngiosarcoma of the head and neck is a rare tumour of vascular origin that affects the elderly. A 74-year-old man who presented with bruise-like macules of the scalp and face is reported. He was treated for a few months with different antibiotics and anti-allergic medication by his own family doctor, and referred for specialist opinion when he failed to derive any benefits from the medications. A biopsy was obtained from the lesion and proved to be an angiosarcoma. A review of the literature indicates that the most important prognostic factor in this particular disease is the size of the lesion on presentation, hence the importance of early diagnosis. This case is reported, and the literature for similar cases is reviewed, to highlight the diagnostic and therapeutic aspects of this uncommon aggressive tumour in an attempt to help in the process of early diagnosis.
41
Mazeh, Haggi, Joy Benavidez, Jennifer L. Poehls, Linda Youngwirth, Herbert Chen i Rebecca S. Sippel. "In Patients with Thyroid Cancer of Follicular Cell Origin, a Family History of Nonmedullary Thyroid Cancer in One First-Degree Relative Is Associated with More Aggressive Disease". Thyroid 22, nr 1 (styczeń 2012): 3–8. http://dx.doi.org/10.1089/thy.2011.0192.
Pełny tekst źródła
42
Bunt, Jens, Sander Lambo, Jonathan Lim, Monika Mauermann, Stefan Pfister, Linda Richards i Marcel Kool. "ETMR-13. NFI GENES IN ETMR TUMORIGENESIS AND NEURODEVELOPMENT". Neuro-Oncology 22, Supplement_3 (1.12.2020): iii325. http://dx.doi.org/10.1093/neuonc/noaa222.217.
Pełny tekst źródłaStreszczenie:
Abstract Embryonal tumors with multilayered rosettes (ETMRs) are aggressive pediatric embryonal brain tumors with a universally poor prognosis. These tumors are commonly characterized by amplification of C19MC, but other miRNA-related aberrations, such as DICER mutations or MIR17HG amplifications, are also observed. Nevertheless, it remains unknown how these aberrations are driving the tumorigenesis. We applied miRNA target prediction to investigate the downstream targets shared by these aberrations affecting normal brain development and tumorigenesis. The nuclear factor one (NFI) family of transcription factors were found to be top candidates shared by both miRNA clusters. These genes are expressed at very low levels in ETMRs, in contrast to other brain tumors. During normal brain development these genes are expressed in radial glial progenitors and are required for the transition of proliferation to differentiation. Since radial glial progenitors are the potential cell-of-origin of ETMRs, we hypothesize that downregulation of NFI is required for the proliferative, undifferentiated state of ETMRs. Indeed, mouse models with deletion of an Nfi family member display sustained proliferation and delayed differentiation of radial glial progenitors during development. This leads into brain overgrowth, which has also been observed in humans with intellectual disabilities caused by NFI haploinsufficiency. When multiple Nfi family members are simultaneously targeted in mice, the progenitors are retained and both neurogenesis and gliogenesis are inhibited, resulting in a neuropathology similar to that of human ETMR tumors. Hence, downregulation of NFI genes resulting from miRNA aberrations could contribute to the developmental state and possibly tumorigenesis of ETMRs.
43
Bouchoucha, Yassine, Arnault Tauziède-Espariat, Arnaud Gauthier, Delphine Guillemot, Dorian Bochaton, Julien Vibert, Matthieur Carton i in. "ETMR-03. Intra- and extra-cranial BCOR-ITD tumours are separate entities within the BCOR-rearranged family". Neuro-Oncology 24, Supplement_1 (1.06.2022): i49. http://dx.doi.org/10.1093/neuonc/noac079.181.
Pełny tekst źródłaStreszczenie:
Abstract BCOR-ITD tumours form an emerging family of aggressive entities with an internal tandem duplication (ITD) in the last exon of the BCOR gene. The family includes cerebral tumours, termed central nervous system BCOR-ITD (CNS BCOR-ITD), and sarcomatous types described in the kidney as clear cell sarcoma of the kidney (CCSK), in the endometrium as high-grade endometrial stromal sarcoma (HG-ESS), in bone, and in soft tissue as undifferentiated round cell sarcoma (URCS) or primitive myxoid mesenchymal tumour of infancy (PMMTI). Based on a series of 33 retrospective cases, including 10 CNS BCOR-ITD and 23 BCOR-ITD sarcomas, we interrogated the homogeneity of the entity regarding clinical, radiological and histopathological findings, and molecular signatures. Whole transcriptomic sequencing and DNA methylation profiling were used for unsupervised clustering. Histopathological review revealed marked differences between CNS BCOR-ITD and BCOR-ITD sarcomas. These two groups were consistently segregated by unsupervised clustering of expression (n=22) and DNA methylation (n=21) data. Proximity between the two groups may result from common somatic changes within key pathways directly related to the novel activity of the ITD itself. Conversely, comparison of gene signatures with single-cell RNAseq atlases suggests that the distinction between BCOR-ITD sarcomas and CNS BCOR-ITD may result from differences in cells of origin.
44
Franzin, Lucimara Cheles da Silva, Fernanda Mara Franzin i Simone Tetu Moysés. "VIOLÊNCIA DOMÉSTICA CONTRA CRIANÇAS E ADOLESCENTES: PREVALÊNCIA EM CIDADE DO SUL DO BRASIL". Colloquium Vitae 4, nr 2 (19.12.2012): 79–84. http://dx.doi.org/10.5747/cv.2012.v004.n2.v064c.
Pełny tekst źródłaStreszczenie:
The aim of this study was to investigate domestic violence against children and adolescents in Curitiba-Pr. It was realized adescriptive exploratory research, with quantitative approach. It was analyzed the notification register basis of the Protection Network of children and adolescents at risk of violence in Curitiba-Brazil, 2004-2009. The variables included the socio-demographic profile of the victims, types of violence, origin of notification, information about the aggressor, severity of the case, injuries. Thedata had been stored in the software EPI-INFO and analyzed by software SPSS 17.0. It was analyzed the frequency distribution and associations between variables, using chi-square test, with the level of significance of 5%.The 19.316 notifications showed aprevalence of 88.4 of domestic violence, with 17,082 cases, as neglect with 9,742 notifications (57.0%). From the total, 43.9% of the cases were considered serious, the most affected age was 5 to 14 years old, with balance between genders. Among aggressors, the mother was the most important in cases of negligence. The physical sequels (20.2%) mainly reached head, arms and legs, characterized as bruising, cuts, and fractures. It was concluded that, in the studied period, domestic violence had greater visibility in this city, with more notifications of neglect. It is important to increase politics on domestic violence prevention, with continuous violence and family support strategies, supporting victims, family and aggressors
45
St-Pierre, Yves. "Towards a Better Understanding of the Relationships between Galectin-7, p53 and MMP-9 during Cancer Progression". Biomolecules 11, nr 6 (14.06.2021): 879. http://dx.doi.org/10.3390/biom11060879.
Pełny tekst źródłaStreszczenie:
It has been almost 25 years since the discovery of galectin-7. This member of the galectin family has attracted interest from many working in the cancer field given its highly restricted expression profile in epithelial cells and the fact that cancers of epithelial origin (carcinoma) are among the most frequent and deadly cancer subtypes. Initially described as a p53-induced gene and associated with apoptosis, galectin-7 is now recognized as having a protumorigenic role in many cancer types. Several studies have indeed shown that galectin-7 is associated with aggressive behavior of cancer cells and induces expression of MMP-9, a member of the matrix metalloproteinases (MMP) family known to confer invasive behavior to cancer cells. It is therefore not surprising that many studies have examined its relationships with p53 and MMP-9. However, the relationships between galectin-7 and p53 and MMP-9 are not always clear. This is largely because p53 is often mutated in cancer cells and such mutations drastically change its functions and, consequently, its association with galectin-7. In this review, we discuss the functional relationships between galectin-7, p53 and MMP-9 and reconcile some apparently contradictory observations. A better understanding of these relationships will help to develop a working hypothesis and model that will provide the basis for further research in the hope of establishing a new paradigm for tackling the role of galectin-7 in cancer.
46
Galvão, Rafaelo M., Andrea C. Mariano, Dirce F. Luz, Poliane F. Alfenas, Eduardo C. Andrade, Francisco M. Zerbini, Márcia R. Almeida i Elizabeth P. B. Fontes. "A naturally occurring recombinant DNA-A of a typical bipartite begomovirus does not require the cognate DNA-B to infect Nicotiana benthamiana systemically". Journal of General Virology 84, nr 3 (1.03.2003): 715–26. http://dx.doi.org/10.1099/vir.0.18783-0.
Pełny tekst źródłaStreszczenie:
Species of the genus Begomovirus (family Geminiviridae) found in the western hemisphere typically have a bipartite genome that consists of two 2·6 kb DNA genomic components, DNA-A and DNA-B. We have identified and cloned genomic components of a new tomato-infecting begomovirus from Brazil, for which the name Tomato crinkle leaf yellows virus (TCrLYV) is proposed, and a DNA-A variant of Tomato chlorotic mottle virus (ToCMV-[MG-Bt1]). Sequence analysis revealed that TCrLYV was most closely related to ToCMV, although it was sufficiently divergent to be considered a distinct virus species. Furthermore, these closely related viruses induce distinguishable symptoms in tomato plants. With respect to ToCMV-[MG-Bt1] DNA-A, evidence is presented that suggests a recombinant origin. It possesses a hybrid genome on which the replication compatible module (AC1 and replication origin) was probably donated by ToCMV-[BA-Se1] and the remaining sequences appear to have originated from Tomato rugose mosaic virus (ToRMV). Despite the high degree of sequence conservation with its predecessors, ToCMV-[MG-Bt1] differs significantly in its biological properties. Although ToCMV-[MG-Bt1] DNA-A did not infect tomato plants, it systemically infected Nicotiana benthamiana, induced symptoms of mottling and accumulated viral DNA in the apical leaves in the absence of a cognate DNA-B. The modular rearrangement that resulted in ToCMV-[MG-Bt1] DNA-A may have provided this virus with a more aggressive nature. Our results further support the notion that interspecies recombination may play a significant role in geminivirus diversity and their emergence as agriculturally important pathogens.
47
Plummer, Jasmine. "Abstract IA023: Creating a single cell and spatial atlas of breast, ovarian and prostate cancer for African ancestry". Cancer Epidemiology, Biomarkers & Prevention 32, nr 1_Supplement (1.01.2023): IA023. http://dx.doi.org/10.1158/1538-7755.disp22-ia023.
Pełny tekst źródłaStreszczenie:
Abstract The US Black population is composed of both US born Black and immigrant Black populations from the Caribbean and Africa. Normal tissues in Black individuals independent of their country of birth or residence is woefully understudied. Black individuals disproportionately develop aggressive pathologic diseases which are treatment refractory or resistant, leading to premature deaths. In women, breast cancer is the most common cancer in Black women in the US, most common non-viral driven cancer in women in Africa and the Caribbean. Black women develop this disease younger than other ancestral groups and have higher incidence of metaplastic and triple negative breast cancer - aggressive pathologies. Ovarian cancer is rare in US-born Black (USB) while in both West and East Africa and the Caribbean, ovarian cancer is more common with more serous pathologies and earlier onset. While the incidence of prostate cancer among Black men in the US is declining, it is increasing in the Caribbean and Africa. Black men disproportionately develop prostate cancer young, have strong family history of prostate cancer, develop aggressive pathologies that are usually refractory to standard of care therapies. With the African-Caribbean Cancer Consortium (AC3) and Transatlantic Gynecologic Cancer Research Consortium, a single cell atlas of the cells of origin and tumors of breast, ovarian and prostate cancer will be constructed from samples across West and East Africa, the Caribbean and the USA in Black individuals. Pairing this single cell atlas with spatial approaches, we hope to develop a benchmark to confidently measure and interpret ancestral genomic differences at the cellular level. In this session, we will discuss how we are using these approaches to look at the relationship between African ancestry, aggressive disease biology, early onset warrants us to study the tissue composition, the proportion of sub-populations that are thought to give rise to tumors and the interplay with germline genetics. Citation Format: Jasmine Plummer. Creating a single cell and spatial atlas of breast, ovarian and prostate cancer for African ancestry [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr IA023.
48
La Quaglia, M. P., M. Morris, J. Shia, K. Idrees, S. Rosenberg, N. Ishill, R. C. Shamberger, J. J. Doski, G. Heller i P. B. Paty. "A retropective analysis of colorectal cancer in adolescents and young adults: A report from the Surgical Committee of the Children's Oncology Group". Journal of Clinical Oncology 25, nr 18_suppl (20.06.2007): 9568. http://dx.doi.org/10.1200/jco.2007.25.18_suppl.9568.
Pełny tekst źródłaStreszczenie:
9568 Background: The genetic origin, clinical features, and prognosis of early onset colorectal carcinomas (CRC diagnosed ≤ 30 years of age) are poorly understood. To evaluate these parameters, we performed a multi-institutional review. Methods: This is a retrospective review accomplished through a survey of Children's Oncology Group Institutions. 167 patients (median age=21yrs., range 10–30 yrs.) with adequate material were reviewed. Immunostaining for mismatch repair (MMR) proteins (MSH2, MLH1, MSH6, PMS1) was performed for 119 cases with sufficient archival tumor. Survival estimates were computed using Kaplan Meier methodology and associations assessed using a log-rank test or Cox proportional hazards. Results: The overall stage of disease at presentation: 9% stage I, 16% stage II, 34% stage III, 38% stage IV, and 4% unknown. Site of origin in the colon included: 17% right, 8% transverse, 14% left, 15% sigmoid, 37% rectosigmoid or rectum, and 9% unknown. 37% of cancers were poorly differentiated and 23% had signet ring cell features. A family history of CRC was reported in 46 (40%) of 114 patients for whom data were available. HNPCC criteria (Amsterdam II) were met in only 10 of these cases. MMR protein expression was deficient in 20 of 119 evaluable cases (17%) and was correlated to HNPCC status (P<0.0001) but not to other clinical features. R0 resection was accomplished in 115 patients. Of 159 patients with follow-up data the median survival was 44 mos. (95% CI: 31–65mos.). The 1, 3, and 5-year overall survival were 81%, 54%, and 42% respectively. Variables associated with overall survival in univariate analysis included: age (p=0.02), family history of CRC (P=0.03), HNPCC status (P=0.03), stage (P<0.0001), grade (P=0.0003), and R0 status (P<0.0001). Conclusions: CRC in this age group is associated with clinical features distinct from adult CRC, including advanced stage, high grade pathology, and poor survival. The majority of cases occur sporadically, and less than 25% can be associated with HNPCC either by clinical criteria or by MMR immunostaining. Future studies should pursue more detailed molecular characterization, improved detection strategies, and better treatment to improve outcome for these aggressive cancers. No significant financial relationships to disclose.
49
Geribaldi-Doldán, Noelia, Irati Hervás-Corpión, Ricardo Gómez-Oliva, Samuel Domínguez-García, Félix A. Ruiz, Irene Iglesias-Lozano, Livia Carrascal i in. "Targeting Protein Kinase C in Glioblastoma Treatment". Biomedicines 9, nr 4 (4.04.2021): 381. http://dx.doi.org/10.3390/biomedicines9040381.
Pełny tekst źródłaStreszczenie:
Glioblastoma (GBM) is the most frequent and aggressive primary brain tumor and is associated with a poor prognosis. Despite the use of combined treatment approaches, recurrence is almost inevitable and survival longer than 14 or 15 months after diagnosis is low. It is therefore necessary to identify new therapeutic targets to fight GBM progression and recurrence. Some publications have pointed out the role of glioma stem cells (GSCs) as the origin of GBM. These cells, with characteristics of neural stem cells (NSC) present in physiological neurogenic niches, have been proposed as being responsible for the high resistance of GBM to current treatments such as temozolomide (TMZ). The protein Kinase C (PKC) family members play an essential role in transducing signals related with cell cycle entrance, differentiation and apoptosis in NSC and participate in distinct signaling cascades that determine NSC and GSC dynamics. Thus, PKC could be a suitable druggable target to treat recurrent GBM. Clinical trials have tested the efficacy of PKCβ inhibitors, and preclinical studies have focused on other PKC isozymes. Here, we discuss the idea that other PKC isozymes may also be involved in GBM progression and that the development of a new generation of effective drugs should consider the balance between the activation of different PKC subtypes.
50
Harrington, Thomas C., Daniel J. Thorpe i Acelino C. Alfenas. "Genetic Variation and Variation in Aggressiveness to Native and Exotic Hosts Among Brazilian Populations of Ceratocystis fimbriata". Phytopathology® 101, nr 5 (maj 2011): 555–66. http://dx.doi.org/10.1094/phyto-08-10-0228.
Pełny tekst źródłaStreszczenie:
Ceratocystis fimbriata is a complex of many species that cause wilt and cankers on woody plants and rot of storage roots or corms of many economically important crops worldwide. In Brazil, C. fimbriata infects different cultivated crop plants that are not native to Brazil, including Gmelina arborea, Eucalyptus spp., Mangifera indica (mango), Ficus carica (fig), and Colocasia esculenta (inhame). Phylogenetic analyses and inoculation studies were performed to test the hypothesis that there are host-specialized lineages of C. fimbriata in Brazil. The internal transcribed spacer region ribosomal DNA sequences varied greatly but there was little resolution of lineages based on these sequences. A portion of the MAT1-2 mating type gene showed less variation, and this variation corresponded more closely with host of origin. However, mango isolates were found scattered throughout the tree. Inoculation experiments on the five exotic hosts showed substantial variation in aggressiveness within and among pathogen populations. Native hosts from the same families as the exotic hosts tended to be less susceptible than the cultivated hosts, but there was little correlation between aggressiveness to the cultivated and native hosts of the same family. Cultivation and vegetative propagation of exotic crops may select for strains that are particularly aggressive on those crops.