Rozprawy doktorskie na temat „FAMILY OF MAP”
Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych
Sprawdź 50 najlepszych rozpraw doktorskich naukowych na temat „FAMILY OF MAP”.
Przycisk „Dodaj do bibliografii” jest dostępny obok każdej pracy w bibliografii. Użyj go – a my automatycznie utworzymy odniesienie bibliograficzne do wybranej pracy w stylu cytowania, którego potrzebujesz: APA, MLA, Harvard, Chicago, Vancouver itp.
Możesz również pobrać pełny tekst publikacji naukowej w formacie „.pdf” i przeczytać adnotację do pracy online, jeśli odpowiednie parametry są dostępne w metadanych.
Przeglądaj rozprawy doktorskie z różnych dziedzin i twórz odpowiednie bibliografie.
March, Helen Nicola. "Regulation of AP-1 family proteins by MAP kinase pathways". Thesis, University of Cambridge, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612889.
Pełny tekst źródłaWronka, Agata Ewa. "Separatrix splitting for the extended standard family of maps". Thesis, University of Edinburgh, 2011. http://hdl.handle.net/1842/5043.
Pełny tekst źródłaYang, Tun-Hsiang. "Family based liquid association study an approach to map the disease genes for the complex trait /". Diss., Restricted to subscribing institutions, 2008. http://proquest.umi.com/pqdweb?did=1610653951&sid=1&Fmt=2&clientId=1564&RQT=309&VName=PQD.
Pełny tekst źródłaO’Connor, Teresia M., Louise C. Mâsse, Andrew W. Tu, Allison W. Watts, Sheryl O. Hughes, Mark R. Beauchamp, Tom Baranowski i in. "Food parenting practices for 5 to 12 year old children: a concept map analysis of parenting and nutrition experts input". BIOMED CENTRAL LTD, 2017. http://hdl.handle.net/10150/625794.
Pełny tekst źródłaRaman, Malavika. "Identification of intracellular signaling pathways regulated by the TAO family of mammalian STE20p kinases". Access to abstract only; dissertation is embargoed until after 5/15/2007, 2006. http://www4.utsouthwestern.edu/library/ETD/etdDetails.cfm?etdID=163.
Pełny tekst źródłaSixsmith, Jaimie. "Development of real time PCR to map poly(ADP-ribose) polymerase family gene expression in human brain tissue and cultured cells". Thesis, University of Newcastle Upon Tyne, 2005. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.413948.
Pełny tekst źródłaAlvarez, Susana. "Interlaced Distortions". The Ohio State University, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=osu1308186327.
Pełny tekst źródłaChládeková, Paulína. "Zaměření rodinného domu v Brně Žabovřeskách". Master's thesis, Vysoké učení technické v Brně. Fakulta stavební, 2020. http://www.nusl.cz/ntk/nusl-414308.
Pełny tekst źródłaBowles, Mollie Ellen. "Interactions Between Phytophthora spp. and Castanea spp. and the Creation of a Genetic Linkage Map for the F1 Parent in a First-Generation Backcross Family of Castanea spp". NCSU, 2006. http://www.lib.ncsu.edu/theses/available/etd-08162006-093218/.
Pełny tekst źródłaDurant, Richard P. "A Concept Mapping Needs Assessment of Young Families with Parental Cancer". Antioch University / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=antioch1307109066.
Pełny tekst źródłaMaza, Paloma Korehisa [UNIFESP]. "Estudos sobre o envolvimento de “membrane rafts” e a ativação de quinases de células epiteliais durante a interação com paracoccidioides brasiliensis". Universidade Federal de São Paulo (UNIFESP), 2008. http://repositorio.unifesp.br/handle/11600/9604.
Pełny tekst źródłaMuitos patógenos são capazes de manipular a sinalização de células do hospedeiro para facilitar sua infecção. Nesta tese, demonstramos que o fungo Paracoccidioides brasiliensis promove um aumento na ativação de ERK1/2 e SFKs em células epiteliais A549 (de pulmão humano), de aproximadamente 6 e 7 vezes, respectivamente, em relação aos níveis basais. Utilizando PP2, inibidor da atividade de SFKs, e PD98059, inibidor da ativação da via ERK1/2, verificamos que a ativação de ERK1/2 é parcialmente dependente de SFKs ativadas e que provavelmente outras quinases também estão envolvidas neste evento. Além da modulação da sinalização de células do hospedeiro, diversos estudos têm demonstrado que patógenos seqüestram domínios presentes nas membranas da célula hospedeira denominados “membrane rafts”, os quais são enriquecidos em esfingolipídeos e colesterol e estão envolvidos em diversos eventos celulares, incluindo a sinalização celular. Por diferentes metodologias, como a desorganização de “membrane rafts” por drogas que extraem (metil-β- ciclodextrina, MβCD) ou que se ligam (nistatina) ao colesterol, e a localização do gangliosídeo GM1, um marcador de “membrane rafts”, utilizando a subunidade B da toxina da cólera (CTB), mostramos o envolvimento destes domínios de membranas de células epiteliais na adesão de P. brasiliensis. A partir do isolamento de membranas resistentes a detergente (DRMs) de células epiteliais após incubação com o fungo, mostramos a ativação e o deslocamento de SFKs para as frações que contêm os “membrane rafts”. Além disso, verificamos que a depleção do colesterol com MβCD inibe completamente a ativação de SFKs, corroborando a importância dos domínios de membranas para a ativação destas quinases. Os resultados apresentados nesta tese demonstram, pela primeira vez, que fungos patogênicos modulam a organização e a atividade de “membrane rafts” de células hospedeiras para o estabelecimento da infecção.
Many pathogens are able to manipulate host cell signaling in order to facilitate infection. In this thesis, we demonstrated that the fungus Paracoccidioides brasiliensis promotes an increase of ERK12 and SFK activation in A549 epithelial cells (human lung cells), by approximately 6- and 7-fold over basal levels, respectively. By using PP2, inhibitor for SFK activity, and PD98059, inhibitor for ERK1/2 activation, we verified that ERK1/2 activation is partially dependent of activated SFKs and probably other kinases are involved in this event. Besides modulation of host cell signaling, several studies have been demonstrated that pathogens hijack domains that are present in host cell membranes called membrane rafts, which are cholesterol- and sphingolipidenriched domains, that are involved in several cell events, including cell signaling. By using several approaches, such as membrane rafts disruption with cholesterolextractor (methyl-β-cyclodextrin, MβCD) or –binding (nystatin) drugs, and the localization of ganglioside GM1, a membrane raft marker, by using cholera toxin subunit B (CTB), we showed the involvement of these epithelial cell membrane domains in P. brasiliensis adhesion. By isolating detergent-resistant membrane (DRM) from epithelial cells after incubation with this fungus, we showed the activation and the dislodgment of SFKs to fractions which contain membrane rafts. Moreover, we verified that cholesteroldepletion with MβCD completely inhibits SFK activation, corroborating the importance of membrane domains in activation of these kinases.The results presented in this thesis demonstrate for the first time that pathogenic fungi may modulate the organization and activity of host cell membrane rafts for infection establishment.
TEDE
BV UNIFESP: Teses e dissertações
Arvidsson, Oona, i Alexander Taubert. "”Man måste bli allt – man måste vara mamma, pappa, syskon, man” : En fenomenologisk studie om familjeåterförening för ensamkommande barn i Sverige". Thesis, Södertörns högskola, Socialt arbete, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:sh:diva-34172.
Pełny tekst źródłaThe purpose of this study was to explore how unaccompanied minors describe their experiences of family reunification, and what importance or implications it has for them. Furthermore, our aim was to find out how they experience the withdrawal of public social support after the arrival of their families. We interviewed three persons who were unaccompanied minors by the arrival to Sweden, and later reunified with their families in Sweden. The theoretical framework of this qualitative interview study is formed by Schütz’ phenomenological sociology and Berger and Luckmann’s theory of the social construction of reality. We complemented the theoretical framework with Boss’ theory of ambiguous loss and Greif’s theory of ambiguous reunification. The method for analysis used is Interpretative Phenomenological Analysis (IPA). The main results shown in this study is that there seems to be an ambiguity in the family reunification experience. On one hand, the family reunification was of big importance to the participants. On the other hand, the time following the reunification was characterized by a great responsibility for the family. Finally, we discuss possible shortcomings in the way the public social support for families after family reunification is provided.
Hultin, Hanna. ""Även om man inte blir exakt som vilken annan familjsom helst" : En kvalitativ studie om föreställningar kring familjehemsuppdraget". Thesis, Linnéuniversitetet, Institutionen för socialt arbete (SA), 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-64808.
Pełny tekst źródłaGresh, Kristen Ann. "The Family of man : histoire critique d'une exposition américaine". Paris, EHESS, 2010. http://www.theses.fr/2010EHES0132.
Pełny tekst źródłaIn 1955, Edward Steichen organized the historic exhibition "The Family of Man" at the Museum of Modem Art (MoMA) in New York. Under the auspices of United States Information Agency, it was exhibited throughout the world and gained a mythic status. This dissertation looks beyond that myth, in order to present a reference document with background information not previously examined. It is based on the author's research involving personal interviews with photographers who contributed to the exhibition as well as the analysis of unpublished archival documents. Part 1 explores the MoMA's World War II programs that paved the way for "The Family of Man", Steichen's career and his role as director of the museum's photography department. Part II traces the origins of the project, showing Steichen's various collaborations through a thorough examination of his correspondence, his individual and group meetings with photographers, and, in particular, his decisive trip across Europe. Part III examines the methods and results of Steichen's work, as both photographer and editor. A discussion of the sources of "The Family of Man", mainly photojournalistic, illustrates the contours of press photography at the time followed by a synopsis of the exhibition and its international circulation, in several versions. This dissertation demonstrates how "The Family of Man" was a tour de force in the history of photography because of Steichen's ability to combine his innovative photographic and editing skills that exploited the medium to communicate a political agenda that is a reflection of a complex network of colleagues, friends and acquaintances from the world of photography and of politics
Jasaitis, Audrius. "Electrogenic reactions in the heme-copper oxidase family of enzymes". Helsinki : University of Helsinki, 2002. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/jasaitis/.
Pełny tekst źródłaKukkonen, Maini. "Structure-function relationships in the omptin family of enterobacterial proteases /". Helsinki : University of Helsinki, 2003. http://ethesis.helsinki.fi/julkaisut/mat/bioti/vk/kukkonen/.
Pełny tekst źródłaLouk, Tyler M. "An intergroup perspective on family targeted hurtful messages used in romantic relationships". Morgantown, W. Va. : [West Virginia University Libraries], 2008. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5796.
Pełny tekst źródłaTitle from document title page. Document formatted into pages; contains v, 49 p. Vita. Includes abstract. Includes bibliographical references (p. 32-38).
Cederholm, Tova, i Maja Hagström. "”Det är något man läser om på högskolan” : En kvalitativ studie om socialarbetarens syn på arbetet med stigmatisering och stämpling". Thesis, Högskolan Dalarna, Institutionen för hälsa och välfärd, 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:du-36450.
Pełny tekst źródłaPrevious research has shown that families receiving interventions from the social services are stigmatized and labeled. The purpose of this study is to examine, among social workers within the family unit’s awareness of and work with stigmatization and labeling regarding the families they meet in their work. Stigma and labeling theory make up the theoretical framework for the study. It was conducted with a qualitative approach with six semi-structured interviews, the data was analyzed with a thematic analysis. Two themes emerged: de-prioritized work and indirect work. The results showed that the social workers awareness about family’s risk of being stigmatized and labeled was low. Guidelines and routines were missing and the work to support the families was indirect and not specified for processing stigma and labeling. It was concluded that there needed to be a greater awareness of the stigmatization and labeling of the clients among the social workers.
McClure, Sarah A. "Using cognitive mapping to describe the family members experiences of living with a problem gambler". access full-text online access from Digital Dissertation Consortium, 2006. http://libweb.cityu.edu.hk/cgi-bin/er/db/ddcdiss.pl?1439658.
Pełny tekst źródłaPage(s) missing in number only; text follows. Page(s) were scanned as received. Adviser: Sandra Bulmer. Includes bibliographical references.
Rice, Jerome Lee. "Examining Family Hierarchy Through the Eyes of Former Mac Baller Gang Members". ScholarWorks, 2019. https://scholarworks.waldenu.edu/dissertations/7952.
Pełny tekst źródłaTsuchiyama, Yoko. ""The Family of Man" : la réception de l'exposition de 1955 jusqu'à aujourd'hui". Thesis, Paris Sciences et Lettres (ComUE), 2018. http://www.theses.fr/2018PSLEH104.
Pełny tekst źródłaThe Family of Man exhibition of Edward Steichen was organized at MoMA in 1955. This thesis addresses the reception of The Family of Man from its creation in 1955 until today, thanks to the reinstallation of the exhibition in the Clervaux Castle in 1994. In the 1950s and 1960s, the exposition was shown in 38 countries. How was The Family of Man exhibition received in certain countries where the itinerant exhibition was shown from 1955 to 1964? How was it reinstalled in the 1990s in Luxembourg in a new context? Why was discourse on the exhibition produced between the two periods when it was no longer there as an object? In fact, there had been reactions to The Family of Man at the time of the itinerant exhibition. Today, the exhibition is visible thanks to the material objects reproduced in the 1950s and the archived documents in addition to the consultation of the catalogue. This allows the spectators to have an actual experience of the exhibition by themselves from their point of view
Curbilié, Camille. "Processus identitaire adolescent en mal de filiation : quels liens et quels lieux pour devenir ?" Thesis, Paris 10, 2015. http://www.theses.fr/2015PA100057.
Pełny tekst źródłaThe psychological functions of certain teenagers born in France and placed in educational institutions, reveals identity sufferance which cannot be understood outside of the sociocultural family’s and institution’s context. The loss of sociocultural references during parental migration, the separation induced by educational placement just as the teenager’s identity and drive reorganization deeply questions the “ temps de passage”. It appears that the original emigrational separation resonates with the placement separation, preventing the subject access to objects, which are the basis for their origins and therefore their future. These young people are just like excluded from filiations, incapable of reaching “historisation”. They search by their own means private references, excluding them from admitted subjectivity, shared by the rest of society. In this way they mark a difficulty to access collective ideals in which the cultural superego normally acts as the psychological representative. “Objectales” relational destructivity reveals intra-psychological, trans-generational and institutional conflict that obliges us to articulate subjectivity and collectivity in order to apprehend the multiplicity of trauma. A reflection based on clinical ground, along with care measures has been lead linked with the specificity of identity sufferance
Kimbrough, Wynne A. ""If a man know not how" an examination of the minister's family life /". Online full text .pdf document, available to Fuller patrons only, 1999. http://www.tren.com.
Pełny tekst źródłaWikström, Maria, i Anna Möllerstrand. "En familj är att man är bra ihop – en diskursanalytisk studie av regnbågsbarns prat om familj och tillblivelse". Thesis, Linköpings universitet, Institutionen för beteendevetenskap och lärande, 2011. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-70367.
Pełny tekst źródłaButler, Jonathan Alexander. "Characterisation of the Campylobacter jejuni motility accessory factor (maf) gene family involved in flagellin glycosylation". Thesis, University of Manchester, 2009. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.518480.
Pełny tekst źródłaLennmyr, Fredrik. "Signal Transduction in Focal Cerebral Ischemia : Experimental Studies on VEGF, MAPK and Src family kinases". Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2002. http://publications.uu.se/theses/91-554-5267-1/.
Pełny tekst źródłaWalti, Lee. "A practical theology on the doctrine of repentance in the life of a family man". Theological Research Exchange Network (TREN), access this title online, 2006. http://www.tren.com/search.cfm?p091-0060.
Pełny tekst źródłaO'Hara, Shifawn R. K. "The Effects of HIV on the Regulation of IL-12 Family Cytokines, IL-12, IL-23, and IL-27 Production in Human Monocyte-derived Macrophages". Thèse, Université d'Ottawa / University of Ottawa, 2012. http://hdl.handle.net/10393/23220.
Pełny tekst źródłaTurner, Elizabeth C. "Acting like a man : a critical investigation into the performance practices of the seduction community". Thesis, University of Warwick, 2013. http://wrap.warwick.ac.uk/59919/.
Pełny tekst źródłaLam, Yeung-Yin. "Resolving disputes within the family of problem gambler in Hong Kong". access abstract and table of contents access full-text, 2006. http://libweb.cityu.edu.hk/cgi-bin/ezdb/dissert.pl?ma-slw-b21847666a.pdf.
Pełny tekst źródła"Master of Arts in arbitration and disputes resolution [MAArbDR]" Title from PDF t.p. (viewed on May 23, 2007) Includes bibliographical references.
Oredsson, Susanna. ""Man kan säga att båda sänder signaler men på olika frekvenser" : en kvalitativ studie om partners upplevelse av att vara i ett parförhållande där den andra partnern har Aspergers syndrom". Thesis, Högskolan Kristianstad, Sektionen för hälsa och samhälle, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:hkr:diva-11089.
Pełny tekst źródłaPflieger, Jacqeline Cornett. "Parental processes and young adults' romantic relationships in traditional, divorced, and remarried family structures". Auburn, Ala., 2005. http://repo.lib.auburn.edu/2005%20Summer/master's/PFLIEGER_JACQUELINE_6.pdf.
Pełny tekst źródłaZhao, Xianjie. "Mediation a popular choice of dispute resolution in family problems : an analysis of reasons, advantages and practice in mainland China and Hong Kong /". access abstract and table of contents access full-text, 2007. http://libweb.cityu.edu.hk/cgi-bin/ezdb/dissert.pl?ma-slw-b22052422a.pdf.
Pełny tekst źródłaTitle from PDF t.p. (viewed on Sept. 7, 2007) "LW6409A, dissertation of MA arbitration and dispute resolution" Includes bibliographical references.
Mulcahy, Lori Ann. "MAPK regulation of DC IL-12 family is exploited by melanoma to subvert Th-1 priming". Thesis, University of Nottingham, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.490963.
Pełny tekst źródłaDe, Bruyn Paul Jacobus. "'n Pastoraal-teologiese studie oor die roeping van die Afrikaanssprekende man tussen die ouderdom van 30-40 in die gesin, kerk en samelewing / Paul Jacobus de Bruyn". Thesis, North-West University, 2004. http://hdl.handle.net/10394/660.
Pełny tekst źródłaThesis (M.Th. (Pastoral))--North-West University, Potchefstroom Campus, 2005.
Lyle, Timothy Scott. ""Check with Yo' Man First; Check with Yo' Man": Perry Appropriates Drag as a Tool to Recirculate Patriarchal Ideology". Atlanta, Ga. : Georgia State University, 2009. http://digitalarchive.gsu.edu/english_theses/52/.
Pełny tekst źródłaTitle from title page (Digital Archive@GSU, viewed June 8, 2010) Shirlene Holmes, Kameelah Martin Samuel, committee co-chairs; Chris Kocela, committee member. Includes bibliographical references(p. 85-87).
Broodo, Beth (Beth Lauren). "Influence of Family Environment on Ease of Discussion of Sexual Issues With a Partner". Thesis, University of North Texas, 1995. https://digital.library.unt.edu/ark:/67531/metadc277679/.
Pełny tekst źródłaQurik, Yvonne. "”Om man börjar från början”. Litteracitetspraktiker i flerspråkiga familjer med små barn". Thesis, Högskolan i Borås, Institutionen Biblioteks- och informationsvetenskap / Bibliotekshögskolan, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-17553.
Pełny tekst źródłaProgram: Masterprogram: Biblioteks- och informationsvetenskap, Digitala bibliotek och informationstjänster
Sánchez, Mir Laura. "Control diferencial de la ruta de MAP quinasas de integridad celular por GTPasas de la familia Rho en Schizosaccharomyces pombe". Doctoral thesis, Universidad de Murcia, 2014. http://hdl.handle.net/10803/277324.
Pełny tekst źródłaLas rutas de señalización mediadas por MAP quinasas (MAPK) tienen un papel fundamental en la respuesta de células eucariotas frente a estímulos ambientales. La levadura con fisión Schizosaccharomyces pombe representa un modelo particularmente adecuado para abordar estudios básicos sobre dichas rutas de señalización, debido a la gran homología funcional que existe entre sus circuitos reguladores y los de organismos superiores. En S. pombe, la ruta de MAPKs de integridad celular (CIP) participa en la regulación de numerosos procesos biológicos como la construcción de la pared celular, la citocinesis, la morfogénesis, la fusión de vacuolas durante el estrés hipotónico, y la homeostasis iónica mediante la modulación de la activación de la MAPK Pmk1 en respuesta a cambios en las condiciones ambientales. Aunque la GTPasa Rho2 es el principal activador de la ruta de integridad celular a través del ortólogo de PKC Pck2, Pmk1 puede ser activada en ausencia de ambos dependiendo de la naturaleza del estímulo recibido, lo que indica la existencia de elementos reguladores adicionales aguas arriba del módulo de MAPKs. Se ha propuesto a la GTPasa Rho1 como candidata para tal función, mientras que el ortólogo de PKC Pck1 parece regular negativamente la actividad de la CIP. Hemos investigado el posible papel de Rho1 y Pck1 como reguladores de la CIP empleando un mutante hipoactivo de Rho1 (rho1-596) y un mutante carente de Pck1 en distintos fondos genéticos. Las evidencias obtenidas mostraron que Rho1 y Pck1 son activadores de la ruta adicionalmente a Rho2 y Pck2, lo que pone de manifiesto la naturaleza ramificada de los mecanismos de señalización que actúan aguas arriba del módulo de MAPKs. Por otra parte Rho2 se localiza en la membrana plasmática y en el área de división celular, y es farnesilada in vivo en el motivo -CAAX de su extremo C-terminal, siendo esta modificación esencial para su localización y función activadora de la CIP. Sin embargo, la presencia de un residuo de cisteína previo al motivo -CAAX sugiere que Rho2 podría encontrarse palmitoilada en dicho residuo. Para estudiar la relevancia biológica de la palmitoilación de Rho2 creamos una serie de cepas que expresan versiones mutantes tanto de Rho2 como de Rho1 afectadas en lipidación, y estudiamos su localización y función biológica. Los resultados obtenidos permitieron concluir que en la levadura con fisión, la GTPasa Rho2 es palmitoilada in vivo, siendo esta modificación crítica para su correcta localización en membrana plasmática y para ejercer su regulación de la morfogénesis y la ruta de integridad celular. Por último, son numerosos los estudios que han puesto de manifiesto la importancia de la localización subcelular de los componentes de los módulos de MAP quinasas en la respuesta a estrés. En el caso de la ruta de integridad celular, la MAPK Pmk1 muestra una localización núcleo/citoplasmática constitutiva, así como en el huso mitótico, el corpúsculo polar del huso, y en el septo durante la separación celular. Sin embargo, a diferencia del modelo descrito en ERK1/2 en mamíferos, el patrón de localización de Pmk1 no se modifica en respuesta a estrés, lo que indica que tanto la forma activa como inactiva de la MAP quinasa son capaces de entrar en el núcleo. En base a esto, nos planteamos el estudio de la relevancia biológica de la localización nuclear de Pmk1 sobre su función biológica. Para ello recurrimos a la caracterización de mutantes de S. pombe que expresan una versión de Pmk1 anclada a la membrana plasmática y excluida del núcleo constitutivamente en distintos fondos genéticos. Los resultados mostraron que aunque la localización nuclear de Pmk1 en Schizosaccharomyces pombe no es crítica para ejercer la mayor parte de sus funciones biológicas, sí es necesaria para la regulación transcripcional en respuesta al estrés de pared celular, lo que revela la importancia del control espacio-temporal de la actividad de las MAPKs en los organismos eucariotas.
SUMMARY Mitogen-activated protein kinase (MAPK) signaling pathways play a fundamental role in the response of eukaryotic cells to environmental changes. Fission yeast Schizosaccharomyces pombe has emerged as an excellent model organism to study mechanisms and cellular events linked to MAPK activation, given the significant functional homology between their regulatory circuits and those of higher cells. In S. pombe the cell integrity pathway (CIP) participates in multiple biological processes like cell wall construction, vacuole fusion during hypotonic stress, cytokinesis, morphogenesis, and ionic homeostasis by fine tuning of MAPK Pmk1 activation in response to various environmental conditions. Although the small GTPase Rho2 is a main positive regulator operating upstream the CIP through protein kinase C ortholog Pck2, Pmk1 can still be activated in the absence of either Rho2 or Pck2 depending on the nature of the stimulus, suggesting the existence of additional upstream regulatory elements to modulate its activity. The essential GTPase Rho1 is a candidate to control the activity of the CIP, whereas Pck1 appears to negatively regulate Pmk1 activity. To study the role of Rho1 GTPase and PKC ortholog Pck1 in the CIP, we characterized a S. pombe mutant that expresses hypomorphic Rho1 allele (rho1-596) and a mutant lacking Pck1 in distinct genetic backgrounds. The evidences obtained in this study revealed that Rho1 and Pck1 are positive upstream activators of the CIP in addition to Rho2 and Pck2 during cell growth and cell wall stress. This model shows the branched nature of the upstream signal network that regulates the CIP. Rho2 positively regulates the CIP and is involved in the control of cell polarity and cell wall biosynthesis in fission yeast. Rho2 locates along the plasma membrane and the division area and it has been described that becomes farnesylated in vivo at its -CAAX motif. This lipid modification appears essential for both localization and function within the MAPK pathway. Moreover, there is a second conserved cysteine residue upstream the Rho2 CAAX motif which might be palmitoylated in vivo like other Rho GTPases such as human RhoB. To investigate the role of palmitoylation in Rho2-signaling we constructed rho2Δ strains expressing the wild type, unpalmitoylated, or unprenylated versions of Rho2 as well as Rho2 chimeras fused to the carboxyl end from the essential GTPase Rho1, and we study their location and Rho2-dependent signalling within the CIP. Our results showed that in fission yeast Rho2 becomes palmitoylated in vivo and this modification is required for plasma membrane localization and proper signaling to the CIP. Pmk1 is constitutively localized in both cytoplasm and nucleus, as well as in the mitotic spindle and septum during cytokinesis. However, contrary to the current model for ERK1/2, its localization pattern appears unaffected by its activation status. In this context, we questioned the biological significance of nuclear localization of MAPK Pmk1. We have addressed this issue by characterization of mutants expressing Pmk1 versions excluded from the cell nucleus and anchored to the plasma membrane in different genetic backgrounds. We have found that nuclear localization of Pmk1 is not critical to exert their biological functions, although its presence in the nucleus is necessary for transcriptional regulation under cell wall stress. These evidences highlight the relevance of the spatial/temporal activity control of MAPK activity in eukaryotes.
Redondo, i. Arolas Mar. "Llegat i vigència de les aportacions de l'exposició "The Family of Man" en la representació fotogràfica de la identitat". Doctoral thesis, Universitat de Barcelona, 2010. http://hdl.handle.net/10803/32049.
Pełny tekst źródłaThis research address the discursive capacity of photography, delimiting specific uses of the photographic medium and analyzing some exhibitions that question the photography that speaks about mankind in relation to its social context. It is for this reason that research takes as its focus of interest The Family of Man photographic exhibition of great relevance attending to the idea of the project, the management of the pictures, and in terms of public reception. Curated by Edward Steichen, was opened at the Museum of Modern Art in New York in 1955. Its study concludes that it is a paradigmatic case of model photography exhibition that brings together many of the issues being and discussed even now around the photography, art, and their social implications. The research reflects the highlights that are shown in some exhibitions and in several artistic attitudes of the late twentieth and twenty-first centuries, and also the critical and reflective attitudes of the authors which seem to reveal directly or indirectly, the inheritance of the purposes of the photographer E. Steichen, the most representative artifex of a photographic movement that tries to reconcile art and common daily life. The review and the analysis of exhibitions outline what has changed in the photography attending to the perception and representation of men and their social relationships, and how these changes have been mirrored in several contemporary art demonstrations about mankind. Likewise studying the works through the time reveals some of the changes that have occurred since the fifties about the conception and understanding of the photographic image in the context of art.
Hörtin, Matilda, i Niki Karimgholipour. "Man tar plats : en kvalitativ studie om könsskillnader i chefers uppfattningar om karriärmöjligheter". Thesis, Stockholms universitet, Sociologiska institutionen, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-125676.
Pełny tekst źródłaJanze, Anna. "Förberedelse för att vårda en partner under pågående palliativ vård. : "...mycket är att man inte vet"". Thesis, Ersta Sköndal högskola, Institutionen för vårdvetenskap, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-2628.
Pełny tekst źródłaBackground: Caring for a family member with a life limiting illness is a big responsibility and it can be experienced as difficult and as a burden but it can also be a source of satisfaction doing good for a loved one. Studies have shown that the situation can be associated with negative consequences for the caregiver. Preparedness is a factor that is associated with positive outcomes of caregiving such as higher levels of wellbeing, less anxiety and higher rewards of caregiving. Aim: To describe caregivers experiences from their stories about preparedness when caring for a partner during palliative care. Method: The study design was descriptive using qualitative in depths interviews and qualitative content analysis. Result: One overarching theme emerged which was Preparedness for caregiving in awareness of death, and two themes witch were Striving for something to relate to when preparing for the worst and Preparedness for caregiving-challenges, responsibilities and possibilities. Discussion: The event could be seen as a transition that caused a major change in the lives of the participants influencing meaning, roles and actions. The overarching theme Preparedness for caregiving in awareness of death could be seen as the meaning influencing the transition and a change in values and priorities in the lives of the participants and in different ways of dealing with the situation. Nurses have an important role and may through a person centered approach understand and increase preparedness through knowing what the transition means for the caregiver and where in the process he or she is.
Johnsson, Hilda. "Man vill ju veta vad som finns där ute... : En studie om unga människors val inför framtiden". Thesis, Linköpings universitet, Institutionen för kultur och kommunikation, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-94250.
Pełny tekst źródłaIn this paper, I have chosen to write about young women's thoughts on career, family life and identity. These substances are things that I think most people are experiencing or have experienced that there are many thoughts and questions about, and I want through my study give these women's view of how to get the puzzle of life go together and how ideas about identity, career and family around this might look like. I will write about this from two points of view, and from the individual level, where I use my interviews to talk about my informant thoughts, and from a broader perspective where I put narratives in a wider context, but the focus is on young people's situation in Sweden.
Eklund, Rimsten Anders, i Mats Larsson. ""Det ger sig självt om man är en bra terapeut". En intervjustudie av hemuppgifter i familjeterapi". Thesis, Linköpings universitet, Avdelningen för kliniska vetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-114905.
Pełny tekst źródłaThe homework is an important part of both Functional Family Therapy (FFT) and Dialectical Behavior Therapy (DBT). The goal of this essay has been to determine if, and in what way, homework is used in the context of family therapy, that is the frame of FFT. One hypothesis at the beginning of this work was that the interactional home assignments have started to be replaced by the behavior oriented ones that are a part of DBT. The individuals participating in the study are all working in a psychiatric outpatient clinic (BUP) in Uppsala. They are all using either Functional Family Therapy (n=3) or Dialectical Behavior Therapy (n=2) as treatment methods. The purpose of the study has been to try to understand more of the homework as a therapeutic instrument, especially the relational homework that family therapists are expected to work out on the basis of a manual that is provided within FFT. Two methods have been used to examine this: a survey and focus group interview. The results show a relatively large width when it comes to the therapists view on and practice of homework, though the general pattern indicates that they work out both relational as well as behavior oriented assignments in their practical work. However, there is a need and a wish of the family therapists to gain more clarity on how to determine and give a family a relational oriented homework. The conclusion of this essay is that a clarification like that is not possible, unless you go to the bottom with and define what the relational function is and how to use it in what within Functional Family Therapy is called the Relational Assessment Phase.
Johansson, Lovisa, i Sabina Stenborg. "..." Det är konstigt att man tvistar om barn som man tvistar om inventarier i hemmet" : En studie om socialsekreterarens syn på barns delaktighet i umgängesärenden". Thesis, Karlstads universitet, Fakulteten för humaniora och samhällsvetenskap (from 2013), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-85676.
Pełny tekst źródłaThe purpose of this study was to investigate how social workers consider the child´s perspective in contact orders and what is crucial when social workers was to assess children’s opinions. The child´s perspective focused on children's participation. The starting point for the study was based on four theories: childhood sociology, Hart's participation ladder, power and age categorization and being or becoming. The study was carried out using a qualitative method where four professional social workers in family law were interviewed. The results showed that the social workers who participated considered the child's perspective in that they work for and actively reflect on the involvement of children in contact orders. They believe that it is important that the children get the opportunity to participate. Social workers believe that there are many factors affecting children’s ability to participate in contact orders, therefore making the subject complex/a complex matter. The factors that emerged from the result were age, maturity, loyalty conflicts, parental consent, the relationship between social workers and children and risk areas. Finally, several suggestions for improvement were discovered that could be utilized to make children even more involved in contact orders than they are today, and that much of that responsibility should lie with the adults.
Biella, Andrea Alexandra do Amaral Silva e. "Famílias no museu de arte: lazer e conhecimento: um estudo sobre o programa educativo Interar-te do MAC USP". Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/48/48134/tde-29052012-135440/.
Pełny tekst źródłaThe research Families in the museum of art: leisure and knowledge a study about the Interar-te Educational Program from MAC USP aims to investigate the motivation of adults who provide their children with cultural and educational activities during their families leisure time, in order to observe the impact of these initiatives on the habit of attending museums of art among these family members. A program called Interar-te, which is developed by the Museum of Contemporary Art of the University of São Paulo (MAC USP), was chosen for this case study. This Program, whose target audience is directed to parents and their children, is held once a month, on Saturdays, between January and November, and is one of the university extension activities provided by the Technical-Scientific Division of Education and Art of MAC USP. It was created to supply an institutional demand of the Museums headquarters, located at Ibirapuera Park, which is a park that receives lots of visitors on weekends because of the leisure options it offers. The concepts of leisure and family were approached, and the principles related to education in art museums were approached in order to provide a better comprehension of the research context. The research was based on methodologies for qualitative research analysis, and other complementary information was collected by using quantitative tools, which were directed to the sample selected for the study. Considering the delimitation of the sample profile, we verified that families play an influential role on adults in relation to the construction of their habits of attending cultural-artistic programs, and that these habits also influence their own families. We also concluded that the Interar-te Educational Program of MAC USP promotes teaching and learning concerning visual arts for people of different ages and promotes integration among the family members who visit the Museum.
Kufskie, Kathy L. "Family functioning and parental divorce as predictors of attachment styles and sexual attitudes in college students". Diss., St. Louis, Mo. : University of Missouri--St. Louis, 2009. http://etd.umsl.edu/r4602.
Pełny tekst źródłaEngström, Maja. "Familj eller karriär i arbetslivet, måste man välja? : -en uppsats om arbetstagares skydd mot diskriminering i arbetslivet". Thesis, Linnéuniversitetet, Institutionen för ekonomistyrning och logistik (ELO), 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-33455.
Pełny tekst źródłaGravida arbetstagare anses vara en riskgrupp på arbetsmarknaden och behöver därförextra skydd mot diskriminering i arbetslivet. Syftet med denna uppsats är att utreda vilket skydd gravida arbetstagare har mot diskriminering i anställningssituationer samt om det finns något motsvarande skydd för manliga arbetstagare gällande rätten tillföräldraledighet.Uppsatsen redovisar nationella och EU-‐rättsliga bestämmelser på området samt praxis som visar hur gravida och föräldralediga arbetstagare behandlas på arbetsmarknaden. Genom Sveriges anslutning till EU måste vi nationellt tillämpa de krav EU ställer på sinamedlemsländer.Uppsatsen visar att gravida arbetstagare har ett starkt rättsligt skydd från diskriminering i arbetslivet, både från DL samt genom direktiv från EU. Arbetsgivare som nekar arbetstagare anställning på grund graviditet gör sig skyldig till direkt diskriminering på grund av kön, eftersom det endast är kvinnor som kan bli gravida. Det är inte av betydelse om det gäller en tidsbegränsad -‐eller tillsvidareanställning. Arbetsgivare får aldrig frångå skyddet gravida arbetstagare har i anställningssituationer. Vidare fastslår uppsatsen att manliga arbetstagare skyddas mot missgynnande i samband med föräldraledighet genom 16 § föräldraledighetslagen. Manliga arbetstagare är dock inte lika starkt skyddad eftersom arbetsgivare tillåts att göra undantag frånmissgynnandeförbudet i vissa situationer.
Randa, Carrie D. "Attributions, coping, self-blame and emotional status in victims of rape and domestic violence /". Electronic version (PDF), 2005. http://dl.uncw.edu/etd/2005/randac/carrieranda.html.
Pełny tekst źródłaReis, Gilcelia Lima da Silva. "Homem-pai: do cenário da provisão material à construção do cuidado". Pontifícia Universidade Católica de São Paulo, 2016. https://tede2.pucsp.br/handle/handle/19345.
Pełny tekst źródłaMade available in DSpace on 2016-11-18T11:33:59Z (GMT). No. of bitstreams: 1 Gilcelia Lima Da Silva Reis.pdf: 565001 bytes, checksum: 6f56584b7a32072858a3db6f2cf88765 (MD5) Previous issue date: 2016-09-19
Conselho Nacional de Desenvolvimento Científico e Tecnológico
This research aims to understand how men-fathers, in the family dynamics of contemporary Brazilian society, experience the exercise of the care of children. Thus, it seeks to discover, describe and analyze how the experiences of parental care have repercussions in the material life conditions: organization, routine and daily home actions, work and play with their children and evaluate motivations, problems, care consequences and loving relationship between parents and sons. The methodology is the qualitative approach to reality based on thematic oral history, from three men-parents with children that make part of the Musical Inclusion Program Guri Santa Marcelina (GSM). As a result, it is possible to say that, in Brazilian society, there are men with very different education, age groups and social levels, who choose to be part of parenting. The act of caring for children is a difficult, but pleasant task, not restricted to supplying basic material needs. In the view of respondent parents-men, care is the expression of love with commitment in all processes of human life
Esta pesquisa tem o objetivo de entender como os homens-pais, na dinâmica familiar da sociedade brasileira contemporânea, vivenciam o exercício do cuidado com os filhos. Assim, busca conhecer, descrever e analisar como as experiências do cuidado paterno vêm repercutindo nas condições materiais de vida: organização, rotina e ações cotidianas da casa, trabalho e lazer com seus filhos e avaliar motivações, dificuldades, consequências do cuidado e relação amorosa entre pais e filhos. A metodologia consiste na abordagem qualitativa da realidade com base na História Oral Temática, a partir de três homens-pais com filhos inseridos no Programa de Inclusão Musical Guri Santa Marcelina (GSM). Como resultados, é possível dizer que, na sociedade brasileira, surgem homens com escolaridade, faixas etárias e níveis sociais bastante distintos, que optam por fazer parte da criação dos filhos. O ato de cuidar dos filhos é tarefa difícil, mas prazerosa e não se restringe a suprir necessidades básicas materiais. Na visão dos homens-pais entrevistados, o cuidado é expressão do amor com comprometimento em todos os processos da vida humana