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Solberg, Ranveig. "EPP-basert protesemodell". Thesis, Norges teknisk-naturvitenskapelige universitet, Institutt for teknisk kybernetikk, 2011. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-12611.
Pełny tekst źródłaSheehan, Michelle Louise. "The EPP and null subjects in Romance". Thesis, University of Newcastle upon Tyne, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435535.
Pełny tekst źródłaAlballay, Sáez Cristián Alberto. "Implementación de servidor EPP para la administración de dominios.cl". Tesis, Universidad de Chile, 2019. http://repositorio.uchile.cl/handle/2250/170451.
Pełny tekst źródłaEn el contexto de la administración de nombres de dominio, existe preocupación por NIC Chile respecto de la robustez y del rendimiento de la plataforma de software actual de su Registro. Se predice un aumento de sus canales de inscripción de nombres de dominio en el corto plazo, por lo que mejorar estos atributos es una prioridad para la organización. Este trabajo fue enfocado en el análisis, diseño e implementación de una nueva plataforma de software para NIC Chile, siguiendo un modelo de arquitectura distinto, que separa las responsabilidades de las distintas piezas de software. Junto a la implementación de esta nueva plataforma de software, se crearon herramientas de medición que permitieron realizar una comparativa entre el software de Registro que NIC Chile venía utilizando en producción desde el año 2013 y la nueva plataforma de software producto del trabajo de esta tesis. La evaluación del producto final demostró que la nueva arquitectura permite un incremento en la robustez y rendimiento, además de agregar una mayor flexibilidad para diseñar procedimientos de escalamiento frente a situaciones de alta demanda. Este conjunto de mejoras permitirán que NIC Chile pueda generar las estrategias y procedimientos que conserven el servicio y prestaciones de primer nivel que caracteriza a la organización.
Eltayeb, Mohammed Soleiman. "Efficient data scheduling for real-time large-scale data-intensive distributed applications". The Ohio State University, 2004. http://rave.ohiolink.edu/etdc/view?acc_num=osu1095719463.
Pełny tekst źródłaCosta, Helton [UNESP]. "A construção da notícia no site Mercosul News: o caso EPP". Universidade Estadual Paulista (UNESP), 2012. http://hdl.handle.net/11449/89431.
Pełny tekst źródłaCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Neste trabalho, o objetivo é analisar de que forma o site Mercosul News, de Ponta Porã, Mato Grosso do Sul, noticiou o Exército do Povo Paraguaio - EPP, no período entre outubro de 2009 e outubro de 2010. Através dessa análise, pretende-se, ao final do trabalho, traçar u m perfil noticioso de acordo com a abordagem que o veículo de comunicação deu ao tema. Para alcançar esse resultado, são usados métodos pertinentes à técnica do estudo de caso combinados à análise de enquadramento e de dados quantitativos referentes à inserção do EPP no periódico virtual. O resultado desse processo teórico culmina num estudo sobre as representações que um objeto pode ter dentro do processo de comunicação midiática, que se dá na busca da transmissão de informações entre determinado meio de veiculação de notícias e o receptor. Nesse sentido, a relação do Mercosul News com o EPP serve como exemplo de uma maneira possível dessa representação do real dentro do jornalismo
This work aims to analyze how the site Mercosul News, from Ponta Porã, Mato Grosso do Sul, reported the Paraguayan People's Army - PPA, in the period between October 2009 and October 2010. Through this analysis, it is intended, at the end of research, to trace a news profile according to the approach which the communication vehicle has given to the theme. To achieve this result, appropriate methods are used to the technique of the case study matched to analysis of the framework and quantitative data regarding the inclusion of PPA in the virtual journal. The result of this process culminates in a theoretical study of the representation that an object can have in the process of mediatic communication which occurs in pursuit of transmitting information between certain new's broadcasting mean and its receiver. In that sense, the relationship of Mercosul News with PPA servesas an exemple of one possible way of representation of reality in journalism
Epp, Alexandra [Verfasser]. "Murine sialylated IgG1 antibodies prevent IgG-dependent allergic reactions / Alexandra Epp". Lübeck : Zentrale Hochschulbibliothek Lübeck, 2017. http://d-nb.info/1137537140/34.
Pełny tekst źródłaCosta, Helton. "A construção da notícia no site Mercosul News : o caso EPP /". Bauru : [s.n.], 2012. http://hdl.handle.net/11449/89431.
Pełny tekst źródłaBanca: Laan Mendes de Barros
Banca: Maria Cristina Gobbi
Resumo: Neste trabalho, o objetivo é analisar de que forma o site Mercosul News, de Ponta Porã, Mato Grosso do Sul, noticiou o Exército do Povo Paraguaio - EPP, no período entre outubro de 2009 e outubro de 2010. Através dessa análise, pretende-se, ao final do trabalho, traçar u m perfil noticioso de acordo com a abordagem que o veículo de comunicação deu ao tema. Para alcançar esse resultado, são usados métodos pertinentes à técnica do estudo de caso combinados à análise de enquadramento e de dados quantitativos referentes à inserção do EPP no periódico virtual. O resultado desse processo teórico culmina num estudo sobre as representações que um objeto pode ter dentro do processo de comunicação midiática, que se dá na busca da transmissão de informações entre determinado meio de veiculação de notícias e o receptor. Nesse sentido, a relação do Mercosul News com o EPP serve como exemplo de uma maneira possível dessa representação do real dentro do jornalismo
Abstract: This work aims to analyze how the site Mercosul News, from Ponta Porã, Mato Grosso do Sul, reported the Paraguayan People's Army - PPA, in the period between October 2009 and October 2010. Through this analysis, it is intended, at the end of research, to trace a news profile according to the approach which the communication vehicle has given to the theme. To achieve this result, appropriate methods are used to the technique of the case study matched to analysis of the framework and quantitative data regarding the inclusion of PPA in the virtual journal. The result of this process culminates in a theoretical study of the representation that an object can have in the process of mediatic communication which occurs in pursuit of transmitting information between certain new's broadcasting mean and its receiver. In that sense, the relationship of Mercosul News with PPA servesas an exemple of one possible way of representation of reality in journalism
Mestre
Epp, Bernhard [Verfasser]. "Grundlegende Untersuchungen zum Absorptionsprozess bei der Dekarbonisierung von Rauchgasen mit Membrankontaktoren / Bernhard Epp". München : Verlag Dr. Hut, 2011. http://d-nb.info/1014848741/34.
Pełny tekst źródłaRabelo, Poliana Camargo. "Argumentos (EPP) nulos no português do Brasil em contextos oracionais finitos e infinitos". reponame:Repositório Institucional da UnB, 2010. http://repositorio.unb.br/handle/10482/7038.
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Esta tese discute o sujeito nulo no português do Brasil (PB), em contextos oracionais finitos e infinitivos, com foco no fenômeno denominado controle. O controle é um fenômeno de correferência (obrigatória) entre um sujeito (nulo) de uma oração (subordinada) e um argumento da oração matriz. Esse fenômeno é frequentemente observado, nas línguas em geral, em contextos não finitos (entre os quais, incluem-se as orações infinitivas). Diversos estudos, entretanto, mostram que no PB esse fenômeno é observado, também, em contextos oracionais finitos, principalmente em orações encaixadas indicativas, quando o sujeito nulo é de 3ª pessoa. Essa propriedade do PB destaca-se no âmbito das línguas românicas (de sujeito nulo), já que nessas línguas o sujeito nulo (de qualquer pessoa) recebe uma interpretação definida/específica. O objetivo desta tese é prover análise que explique a ocorrência do controle nesses contextos. Para tanto, adota-se o quadro teórico da gramática gerativa, mais especificamente aquele desenvolvido por Manzini & Savoia (2005, 2007), o qual unifica os níveis de análise morfológico e sintático. A proposta desenvolvida neste trabalho consiste em considerar que o afixo de pessoa realiza o sujeito no PB e que a interpretação de controle encontrada em orações finitas decorre das especificações lexicais do morfema de concordância de 3ª pessoa, o que leva a crer que há, nessa língua, uma cisão de pessoa. Essa cisão, que alinha, de um lado, 1ª e 2ª pessoas, opondo-as, por outro lado, à 3ª pessoa, abrange outros contextos linguísticos, especialmente aqueles que envolvem a realização de funções gramaticais da oração por pronomes. A análise de que o sujeito é realizado pelo afixo de concordância número-pessoal é estendida ao infinitivo flexionado. Em relação às orações infinitivas, propõe-se, ainda, que o morfema -r é especificado para modo irrealis. Nesse caso, se o infinitivo é impessoal, considera-se que o argumento EPP desse predicado não é realizado sintaticamente, o que significa que esse argumento é uma variável a ser valorada (na interface interpretativa). A valoração dessa variável pode se dar por meio da ligação com um DP na oração matriz ou da ligação por um operador responsável pela interpretação genérica. A interpretação ligada é obrigatória em um subgrupo de orações infinitivas. Isso se deve, por hipótese, à aplicação do fenômeno da reestruturação, observado em contextos de dependência entre oração encaixada (sem tempo) e oração matriz. O controle, então, é tratado como decorrente do fato de o argumento EPP de um predicado ser uma variável. _________________________________________________________________________________ ABSTRACT
This thesis addresses the syntax of null subjects in BP in finite and non-finite contexts, focusing on the phenomenon of control. Control consists of an obligatory coreferential relation between the null subject of an embedded clause and an argument in the matrix clause. This phenomenon is pervasively found crosslinguistically in non-finite contexts, among which the infinitive clauses are found. Nevertheless, various studies show that in BP this phenomenon is also found in finite clauses, mainly in indicative ones, whenever the subject is a null 3rd person one. This property of BP is quite isolated among (null subject) Romance languages, given that in the latter the null subject always receives a definite/specific interpretation, regardless of the person specification. The aim of this thesis is to provide an analysis for the occurrence of control in these contexts in BP, as opposed to the other contexts involving control, which are also found in the other Romance languages. In the analysis, the framework developed in Manzini & Savoia (2005, 2007) is adopted, which is based on the assumption that the morphological and syntactic levels are unified. The analysis presently proposed is that the person affix realizes the subject in BP, the control interpretation found in finite clauses being determined by the lexical specifications of the 3rd person agreement morpheme, which implies that a person split is found in this language. This split, which groups 1st and 2nd person, on the one hand, and 3rd person, on the other hand, is found in other syntactic contexts, particularly those involving the realization of grammatical functions by pronouns. The approach according to which the subject is realized by the person-number affix is extended to the contexts involving the inflected infinitive. Regarding infinitive clauses, it is further proposed that the morpheme –r is specified for irrealis mood. Accordingly, if the infinitive is non-inflected, it is assumed that the EPP argument of this predicate is not syntactically projected, which implies that this argument is interpreted as a variable, which will be assigned an interpretation at the appropriate interface. The variable will receive a value through binding either by an argument in the matrix clause or by a generic operator. The bound interpretation is obligatory in a subset of infinitive clauses. By hypothesis, this is so because of the application of restructuring, found in contexts of tense dependency between the embedded clause (which is not marked for tense) and the matrix clause. Control is thus analysed as arising in contexts in which the EPP argument of a predicate is a variable.
Peters, Karin. "En känsla av att något försvinner En känsla av att något tillförts : En fenomenologisk studie av terapeuters upplevelse av journalskrivning". Thesis, Ersta Sköndal högskola, S:t Lukas utbildningsinstitut, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-4108.
Pełny tekst źródłaIn this qualitative study 5 psychotherapists with psychodynamic specialization were asked to reflect on their experiences concerning the writing of patient records. This material was analyzed using the so-called EPP-method (empirical phenomenological psychological method). The results show both general and distinctive features in how different therapists feel about their patient records routines. All agree that the process of writing patient records contains a number of different functions. It is a tool to communicate with other medical staff and facilities; it is influenced by certain control factors and also by experienced uncertainty concerning the formal rules related to the routines of patient records. Record routines show a high degree of evaluation of personal emotions and experiences together with a fear of revealing too much information about a patient. On the other hand, there is a substantial distinction in how different therapists handle their feelings of conflict related to medical records. The study presents two different possible ways of handling such conflicts. One group of therapists try to reshape the medical journal to make it better adjusted to their personal therapeutic identity. When that becomes impossible they express a feeling of something being lost. In the second group the therapists work harder with those parts in patient record routines that are causing them problems. This results in a feeling that something valuable is being added to their therapeutic identity.
Dixon, Dorian. "Extrusion and thermoforming of polypropylene foams using chemical blowing agents". Thesis, Queen's University Belfast, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343052.
Pełny tekst źródłaLeandersson, Eva. "Avgörande ögonblick/vändpunkter i psykoterapi". Thesis, Ersta Sköndal högskola, S:t Lukas utbildningsinstitut, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-1754.
Pełny tekst źródłaWhat is the crucial turning point in psychotherapy? This is a qualitative study of patients' experiences of the crucial moments/ turning points in their psychotherapy. This study examined patients' experiences and their description of these. The method is phenomenological and is called the EPP- method. The six informants have all attended more than 25 hours of therapy they have all attended psychodynamic therapy. The results revealed no crucial moments/ turning points such as "aha moment". Instead the patients emphasized turning points and insights over time. Two common features emerged in the material. The patients emphasized how they due to the therapy became aware of how they have been stuck in patterns and defense systems due to their early object relations. The patients also emphasized the importance of a "private room" of their own where they could meet themselves together with the therapist.
Gidlööf, Catharina. "Riskerar mediciner att bli substitut för det behandlande samtalet? : en kvalitativ studie kring fyra psykoterapeuter och en läkares erfarenhet av psykoterapi och psykofarmaka". Thesis, Ersta Sköndal högskola, S:t Lukas utbildningsinstitut, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:esh:diva-2074.
Pełny tekst źródłaThe purpose of the study is to describe experiences gained from the use of psychotropic drugs and/or psychotherapy. The study is qualitative in nature and based on interviews with four psychotherapists and physicians. The study takes as its basis a phenomenological perspective. The interviews were analyzed as unprejudiced as possible using the EPP method. The work was based on five overreaching issues; How do we perceive suffering, meaning in relation to psychotropic drugs? Is an individual's ability to feel and think affected by regular use of psychotropic drugs? Can an individual who suffers expect guidance via individual treatment or via available combined treatments? Is an individuals suffering reduced by setting words to the anxiety in psychotherapy? How does the pharmaceutical industry discuss the issue of individual mental suffering? These issues have been tested against a philosophical background that asks the question: Is medicalisation a way of medicating against life itself, a way of making society's shortcomings the individual`s problem? The results are presented in five synopsis which say that suffering can be seen as force for change. Antidepressants have a tendency to numb thoughts and feelings. The patient's own will is important. Medication tends to be a substitute for meeting people and the relationship to pharmaceutical companies problematic for therapists as the industry is also a profit machine.
Ramírez, Jacobo Xavier, i Jacobo Xavier Ramírez. "Subversive Subsistence: Paraguay's Threat of Rural Insecurity and the Criminalization of Campesino Resistance". Thesis, The University of Arizona, 2017. http://hdl.handle.net/10150/626141.
Pełny tekst źródłaMutalib, Abdul Rahim Bin Abdul. "DNA and protein characterisatiob of Mycoplasma hyopneumoniae". Thesis, University of Cambridge, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.339589.
Pełny tekst źródłaPETRAKIS, NIKOLAOS. "Objective Bayes Structure Learning in Gaussian Graphical Models". Doctoral thesis, Università degli Studi di Milano-Bicocca, 2020. http://hdl.handle.net/10281/262921.
Pełny tekst źródłaGraphical models are used to represent conditional independence relationships among variables by the means of a graph, with variables corresponding to graph's nodes. They are widely used in genomic studies, finance, energy forecasting, among other fields. More specifically, for a collection of q variables with conditional independence structure represented by an undirected graph, we assume that the underlying graph's structure is unknown. We are interested in inferring the graph's structure from data at hand. This procedure the bibliography is referred to as Structure Learning, where we use certain techniques for selecting a graphical model to depict conditional independence relationships between these q variables. We start from defining a model space which is consisted by a set of all possible graphical models; then we define a scoring function which enables us to score the different models of the model space and finally, we construct a search algorithm that will navigate through the model space to identify the optimal model that explains the problem at hand. The choice of a scoring function is crucial for optimizing the search procedure through the model space. Our approach to this problem is purely Bayesian for handling uncertainty in a more elaborate fashion. We will use estimates of posterior model probabilities for ranking the models at hand. The specification of a conditional prior on the column covariance matrix is not trivial because each graph under consideration induces a different independence structure and it affects the parameter space. Under this context, we cannot directly use improper priors, since they would result to indeterminate Bayes factors, thus we are required to carefully elicit a prior distribution under each graph, a task that becomes infeasible in higher dimensions. For creating an automated Bayesian scoring technique, we resort to Objective Bayes approaches, which are initiated by an improper prior distribution and their output is a fully usable prior distributions. In this thesis, we propose the use of two alternative Objective Bayes approaches for estimating posterior probabilities of models, namely the Expected Posterior prior approach and the Power-Expected Posterior Prior approach. Both approaches utilize the device of imaginary observations for providing usable prior distributions and are theoretically sounder than the Fractional Bayes Factor of O'Hagan. Our goal is to introduce both the Expected and Power-Expected Posterior prior approaches to the field of structure learning of undirected graphical models and evaluate their performance using certain stochastic search techniques. Diverse simulation scenarios are considered as well as a real-life data application.
KONGTAWELERT, AMARIN. "Developing A Protocol for An Environmentally Preferable Purchasing Plus (EPP+) Program at NASA Glenn Research Center". Cleveland State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=csu1282328402.
Pełny tekst źródłaEkstam, Hanna, i Benjamin Quarmochi. "Design av infästningsanordning för virveldämpare på drönare". Thesis, Linnéuniversitetet, Institutionen för maskinteknik (MT), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-106215.
Pełny tekst źródłaThis work is aimed at producing durable attachments for winglets on a drone, model flying wing, owned by the SSRS. The drone is specifically developed to be used for maritime search and rescue missions and to contribute to increasing the security along the Swedish coast and major inland lakes. During this work only one landing scenario by the drone was studied while creating the attachments, which required to be easy to handle, minimal to no repair work and a durability for 50 landings. The attachments also need to be able to release in case of excessive force during landing which risks jeopardizing the integrity of the wing or winglet. The work followed the DRM-structure and aimed to create a prototype through an exhaustive idea generation technique in three steps using the methods Speedstorming, Brainstorming and SCAMPER. All of these methods go through voting, Pugh analysis and concept screening. After one concept had been singled out its dimensions were decided on and used in calculations to determine its strength. From this information a physical winglet attachment prototype made of expanded polypropylene was created and used in strength and durability tests. Calculations and tests were found to have varying results and the conclusion was made that the material properties regarding elastic deformation and test variables most likely had not fully been taken into account. The tests failed to generate a realistic landing scenario given the requirements but still gave a positive result concerning the prototype's ability to absorb shock loads at landing. This work has resulted in a preliminary winglet attachment prototype which through testing has shown satisfying shock absorbing abilities, and that further testing is required to decide whether the attachment can meet all of the set product requirements.
Epp, Martin [Verfasser]. "Performance evaluation of shuttle-based storage and retrieval systems using discrete-time queueing network models / Martin Epp". Karlsruhe : KIT Scientific Publishing, 2018. http://www.ksp.kit.edu.
Pełny tekst źródłaTheiß, Dennis [Verfasser], i Verena [Akademischer Betreuer] Epp. "Geiselstellungen im Corpus Iuris Civilis Kaiser Justinians und im Corpus Iuris Canonici / Dennis Theiß ; Betreuer: Verena Epp". Marburg : Philipps-Universität Marburg, 2021. http://d-nb.info/1227580215/34.
Pełny tekst źródłaNagase, Erika Inoue. "A inversão locativa no português brasileiro". Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/8/8142/tde-04102007-135055/.
Pełny tekst źródłaIn this dissertation we analyse constructions that involve inversion locative (IL) structures under the Government and Binding framework of the Generative Theory (Chomsky 1981, 1986). IL is considered an unaccusativity and discourse-like phenomenon in languages like English and Spanish. Its pattern structure is the order PP V DP, in which the PP is a locative and the DP is theme argument placed in postverbal position. We departure from a lexical functional analysis from Bresnan (1994) that postulates the Presentational Focus Hypothesis in order to explain the discourse-like function of the construction. In the sequence we present a dicourse-like analysis from Levin & Rappaport Hovav (1995) that proposes the Informationally Light Verb Hypothesis. A third analysis brings a recent minimalist view of the construction through the description of some phenomena that are interrelated - the IL, the topicalization of PPs and the EPP. In order to analyse the IL in Brazilian Portuguese (BP) it is primordial to investigate where BP can be placed within the pro-drop parameter, how nominative Case can be assigned to the subject and in which contexts the inversion occurs in this language. Hence, we do a brief review of the BP literature, departuring from the partitive Case, going to the Intransitive Hypothesis up to sentences with inverted subjects with both intransitive and transitive verbs. We mention one of the first papers about IL in Portuguese, in which Barbosa (1989) offers us some intuitions for an analysis to this phenomenon. Pilati (2002) describes the IL constructions as presentational sentences and Quarezemin (2006) proposes that these constructions are motivated by a dicourse-like function since its subjects must be interpretated as the focus of the sentences. After that we present an analysis to the IL in BP, showing that there are two different kinds of IL - the IL itself and the discourse-like IL. The last chapter presents the conclusions of this research, pointing some similarities between the IL constructions and the topicalization of PPs. More than proposing an analysis to the IL in BP our goal is to show the importance of such phenomenon in a more general view of the BP grammatical studies, considering that IL can be a clue that would characterize BP as an EPP language.
Epp, Anton [Verfasser], i Steinmetzer [Akademischer Betreuer] Torsten. "Entwicklung, Synthese und Charakterisierung neuer Inhibitoren der West-Nil-Virus NS2B-NS3-Protease / Anton Epp ; Betreuer: Steinmetzer Torsten". Marburg : Philipps-Universität Marburg, 2018. http://d-nb.info/116838009X/34.
Pełny tekst źródłaHerencia, Ortega Juan José, Anchiraico Jorge Hugo Mallma, Ochoa Jorge Rodolfo Rasmussen i Loo Luis Alberto Zegarra. "Estrategia de sostenibilidad y rentabilidad aplicada a una PYME, empresa de EPP especializada en guantes de látex industriales". Master's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2017. http://hdl.handle.net/10757/622754.
Pełny tekst źródłaTrabajo de investigación
BRAGA, Thiare Silva Fortes. "Extrato padronizado de própolis EPP-AR® aumenta a sobrevida em camundongos imunossuprimidos com sepse induzida por Candida albicans". Universidade Federal do Maranhão, 2017. http://tedebc.ufma.br:8080/jspui/handle/tede/1867.
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Fundação de Amparo à Pesquisa e ao Desenvolvimento Científico e Tecnológico do Maranhão (FAPEMA)
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPQ)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Propolis produced by bees Apis mellifera is a resinous balsamic material used to protect the hive against fungi, bacteria, viruses and insects. Among the antimicrobial activities of propolis already proven, the antifungal action observed in strains of Candida albicans, commensal fungus of the oro-gastrointestinal tract and skin, associated with opportunistic infections, local or systemic, especially in immunosuppressed patients, are highlighted. The objective of this study was to evaluate the effect of treatment with standardized extract of propolis on systemic infection caused by C. albicans in immunosuppressed mice. Initially the C57Bl/ 6 mice were immunosuppressed with dexamethasone (3mg / kg) for one week and, on the eighth day, were infected intraperitoneally with C. albicans blastopores (2x106). After 24 hours of infection, the daily treatment of the animals with propolis at the doses of 10 and 100 mg/kg was initiated for 15 days intraperitoneally. Immunosuppression with dexamethasone was maintained for all the analysis. At the end of the 15 days, all the animals treated with propolis at the dose of 100 mg/kg were kept alive, while all the animals from the other groups had already died. From then on, it was possible to investigate possible immunological mechanisms to explain this effect. For this, the same protocol of immunosuppression and infection described above was repeated, however, the treatment was performed in a single application of propolis at a dose of 100 mg/kg, 24 hours after infection and the tests were performed 24 hours after this treatment. Treatment with propolis reduced the colony forming units in the peritoneum and spleen. In addition, propolis reversed dexamethasone-induced immunosuppression, increasing the number of circulating leukocytes, mainly neutrophils, proliferation of splenocytes, recruitment of leukocytes to the site of infection and increase of CD4+ T lymphocytes. Regarding the inflammatory mediators, it was observed that the treatment with propolis induced the increase of the ex vivo production of nitric oxide by peritoneal cells and the reduction of plasmatic inflammatory cytokines (IL-6 and TNF-α). Finally, in an in vitro experiment, peritoneal macrophages were treated with dexamethasone (4 μg/mL), for 48 hours, and then treated with propolis (100 μg/mL) for 12 hours. Then, cells were incubated with C. albicans for 1 hour. In this assay, it was observed that propolis increased phagocytosis, without, however, altering Dectin-1 and Mannose receptor expression. In conclusion, the standardized extract of propolis increased life expectancy and reduced C. albicans dissemination in immunosuppressed mice. Such effects are probably due to its ability to reverse dexamethasone-induced immunosuppression, recruit and activate effector immune cells to the site of infection, and reduce serum inflammatory cytokines, thereby reducing the progression of the deleterious aspects of systemic candidemia.
A própolis produzida pelas abelhas Apis melífera é um material balsâmico resinoso, utilizado para a proteção da colmeia contra fungos, bactérias, vírus e insetos. Dentre as atividades antimicrobianas da própolis já comprovadas, destaca-se: a ação antifúngica observada em cepas de Candida albicans, fungo comensal do trato oro-gastrointestinal e da pele, associado a infecções oportunistas, locais ou sistêmicas, em especial, em pacientes imunossuprimidos. O objetivo deste trabalho foi avaliar o efeito do tratamento com Extrato Padronizado de Própolis (EPP-AF®) na infecção sistêmica ocasionada por C. albicans em camundongos imunossuprimidos. Inicialmente, os camundongos C57Bl/6 foram imunossuprimidos com dexametasona (3mg/kg) durante uma semana e, no oitavo dia foram infectados, por via intraperitoneal, com blastóporos de C. albicans (2x106). Após 24 horas da infecção, foi iniciado o tratamento diário dos animais com própolis nas doses de 10 e 100mg/Kg, durante 15 dias, por via intraperitoneal. A imunossupressão com dexametasona foi mantida ao longo de toda a análise. Ao final dos 15 dias, observou-se que todos os animais tratados com própolis na dose de 100mg/Kg, mantinham-se vivos, enquanto todos os animais dos demais grupos já haviam morrido. A partir daí, passou-se a investigar possíveis mecanismos imunológicos que explicassem esse efeito. Para isto, foi repetido o mesmo protocolo de imunossupressão e infecção descritos acima, entretanto, o tratamento foi realizado em uma única aplicação de própolis na dose de 100mg/Kg, 24 horas após a infecção e os ensaios foram realizados 24 horas após esse tratamento. O tratamento com própolis reduziu as unidades formadoras de colônia no peritônio e no baço. Além disso, a própolis reverteu a imunossupressão induzida pela dexametasona, aumentando o número de leucócitos circulantes, principalmente, neutrófilos, a proliferação de esplenócitos, o recrutamento de leucócitos ao sítio da infecção e aumento de linfócitos T CD4+. Em relação aos mediadores inflamatórios, foi observado que o tratamento com própolis induziu o aumento da produção ex vivo de óxido nítrico por células peritoneais e a diminuição das citocinas inflamatórias (IL-6 e TNF-α) plasmáticas. Finalmente, em experimento in vitro, macrófagos peritoneais foram tratados com dexametasona (4µg/mL), por 48 horas, e, em seguida, tratados com própolis (100µg/mL), durante 12 horas. Ao final, as células foram incubadas com C. albicans por 1 hora. Neste ensaio, foi observado que a própolis aumentou a fagocitose, sem, no entanto, alterar a expressão proteica de Dectina-1 e Receptor de manose. Em conclusão, o extrato padronizado de própolis aumentou a expectativa de vida e reduziu a disseminação de C. albicans em camundongos imunosuprimidos. Tais efeitos, provavelmente devem-se a sua capacidade de reverter a imunossupressão induzida pela dexametasona, recrutando e ativando células imunes inatas para o sítio da infecção, além de reduzir as citocinas inflamatórias séricas, diminuindo, assim, a progressão dos aspectos deletérios da candidemia sistêmica.
Guimarães, João Felipe Cury. "Existe puzzle de prêmio de risco acionário (EPP) no mercado brasileiro?: uma análise do período entre 1995 e 2013". reponame:Repositório Institucional do FGV, 2014. http://hdl.handle.net/10438/12047.
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Segundo Sampaio (2002), os modelos intertemporais de equilíbrio começaram a ter a sua eficácia na determinação do retorno dos ativos questionada após a publicação do artigo de Mehra e Prescott em 1985. Tendo como objeto de análise os dados observados no mercado norte-americano, os autores não foram capazes de reproduzir a média histórica do prêmio do retorno das ações em relação ao retorno dos títulos públicos de curto prazo através de parâmetros comportamentais dentro de intervalos considerados plausíveis. Através das evidências, os autores, então, puderam verificar a necessidade de coeficientes exageradamente altos de aversão ao risco para equiparação do prêmio de risco histórico médio das ações norte-americanas, enigma que ficou conhecido como equity premium puzzle (EPP). Foi possível também a constatação de outro paradoxo: a necessidade de taxas de desconto intertemporais negativas para obtenção da média histórica da taxa de juros, o risk-free rate puzzle (RFP). Este trabalho tem como objetivo adaptar os dados do modelo proposto por Mehra e Prescott (2003) ao mercado brasileiro e notar se os puzzles apresentados anteriormente estão presentes. Testa-se o CCAPM com dados brasileiros entre 1995:1 e 2013:4 adotando preferências do tipo utilidade esperada e através da hipótese de log-normalidade conjunta dos retornos. Utiliza-se o método de calibração para avaliar se há EPP no Brasil. Em linha com alguns trabalhos prévios da literatura nacional, como Cysne (2006) e Soriano (2002) que mostraram a existência do puzzle nos períodos de 1992:1-2004:2 e 1980:1-1998:4, respectivamente, conclui-se que o modelo usado por Mehra e Prescott (2003) não é capaz de gerar o prêmio de risco observado na economia brasileira. Sampaio (2002), Bonomo e Domingues (2002) e Issler e Piqueira (2002), ao contrário, não encontram evidências da existência de um EPP brasileiro.
Viegas, Amanda Tobio Grille. "Sujeitos nulos, tópicos e a satisfação do EPP na aquisição de segunda língua: a influência do português brasileiro no inglês". Universidade do Estado do Rio de Janeiro, 2014. http://www.bdtd.uerj.br/tde_busca/arquivo.php?codArquivo=6852.
Pełny tekst źródłaThis study focuses on language transfer, more specifically, on the interference of Brazilian Portuguese (BP) as the native language (L1) on the acquisition of English as a second language/foreign language (L2/FL). The phenomenon under investigation is the use of null vs. overt pronominal subjects. The theoretical framework adopted is the generative linguistic theory based on the Minimalist Program (Chomsky, 1995) and psycholinguistics, responsible for providing procedural models in order to explain how production and comprehension of sentences can be understood. There are different proposals in the literature on L2 acquisition. Considering the phenomenon under investigation, the satisfaction of an EPP feature, responsible for the projection of syntactic subjects in natural languages, would be differently parametrized in BP and in English. BP has become similar to English for referential subjects, but not in respect to expletive subjects. Moreover, it presents topic-subject constructions that may interfere in the acquisition of the negative parametric value for null subjects in English. In order to investigate the changes that have affected BP and observe how learners of English as FL that have BP as their native language are sensitive to the grammaticality of sentences with null subjects in English in different contexts, two experiments were conducted, both with a grammaticality judgment task . The pilot experiment was conducted with learners of basic and advanced levels and presented two distinct types of sentences (Type 1: null subject and type 2: topic + null subject), and a final experiment with learners of basic, intermediate and advanced levels, with three types of sentences (Type 1: null subjects, Type 2: topic + null subject and type 3: conjunction + null subject) .Given the complexity of BP grammar, our hypothesis is that full transfer will not be observed, but rather the emergence of an interlanguage that sometimes is closer to the target language, sometimes differs from it, reflecting processing difficulties imposed by the heavy demands of dealing with the two grammars. The results support the hypothesis indicating that (i) the value of the null subject parameter seems to be transferred from L1 to L2 since we found a high number of incorrect responses, (ii) the interference occurs more strongly in the context of expletive subjects, (iii) there is interference of general restrictions of the L1 grammar (V1 restrictions) in L2, and (iv) the interference decreases with the increasing proficiency in L2. Furthermore, in type 2 sentences, there seems to be a possible interference of BP which leads to the omission of the expletive, indicating a difficulty in integrating information from the constraints imposed by the need to process two languages at specific times in order to prevent the interference from the unwanted language, in this case L1, which requires more resources to be inhibited once it is still the dominant language (SORACE , 1996, 2011).
Vrtílek, Michal. "Nástroje pro správu centrálních registrů DNS". Master's thesis, Vysoké učení technické v Brně. Fakulta informačních technologií, 2010. http://www.nusl.cz/ntk/nusl-237116.
Pełny tekst źródła田中, 智之, i Tomoyuki TANAKA. "EPP 再考 : 英語史における主語の分布を証拠として". 名古屋大学文学部, 2010. http://hdl.handle.net/2237/13415.
Pełny tekst źródłaEpp, Jérémy [Verfasser]. "Time resolved investigations of phase transformations and stresses during heat treatment of steel samples by means of diffraction experiments / Jérémy Epp". Aachen : Shaker, 2016. http://d-nb.info/1106838564/34.
Pełny tekst źródłaYglesias, Tatiana. "Application of process analysis and optimization tools in hit-to-lead and lead optimization phases of drug discovery at EPP, NIBR". Thesis, Massachusetts Institute of Technology, 2010. http://hdl.handle.net/1721.1/59882.
Pełny tekst źródłaCataloged from PDF version of thesis.
Includes bibliographical references (p. 82-84).
Given that research is based on innovation, it has been believed that its activities can only be optimized with equipment upgrade, increment in personnel scientific knowledge, development of new analytical software and/or changing the areas of study. After realizing the limited results achieved with these approaches, lab representatives started to notice the opportunity of introducing process optimization tools, such as Lean and Six Sigma, which showed success in manufacturing environments,. This project analyzes the interrelation between process and results, providing a clear explanation of cause and effect conditions, and a concise list of areas for improvement. Specifically, the document defines a measurement system using process maps and key performance indicators (KPIs). With this, the document describes the current state through historic trends, provides a complete data and root cause analysis for current state description, and provides a process capability study for the available indicators. Implementation of the steps mentioned above show how focus in lab turnaround times have been deviating attention from more impactful improvements, which can greatly affect overall drug discovery duration. Also, the analysis identifies that constant technology changes caused constant adaptation of process procedures, which generated non-value added activities. These non-value added activities today occupy about 50% of a lab associate's time. Lastly, historic data evaluation shows that root cause statistical analysis is limited by the presence of a combination of special and common cause variations. Some of the project recommendations include: incorporation of chemist's knowledge about compound potency, integration of equipment and software information, change in booking system, incorporation of assay and plate criteria, definition of standard procedures for specific activities, and integration of assay development and data submission tools. Overall, these changes can lead to a 50% reduction in the profiling times greater than 60 days, decrease of 62% and 60% in Compound Manager (CM) and Compound Profiler (CP) non-value added times respectively, 30% decrease in CM and CP total duration per assay plate, and increase in profiling time stability and predictability. Despite the fact that timing and scale of available resources will impact the realized benefits, the proposed framework gives EPP the opportunity to assess the improvements by their effect and alignment with goals.
by Tatiana Yglesias.
M.B.A.
S.M.
Boger, Timothy Jared. "Rhealstone Benchmarking of FreeRTOS and the Xilinx Zynq Extensible Processing Platform". Master's thesis, Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/216539.
Pełny tekst źródłaM.S.E.E.
Embedded system designers require deterministic, real-time operating system (RTOS) support for the commonly available processing hardware. The Xilinx Zynq Extensible Processing Platform (EPP) offers software, hardware, and input/output (I/O) programmability on a single chip. The Xilinx Zynq EPP features a Dual ARM Cortex-A9 MPCore, Advanced Microcontroller Bus Architecture (AMBA) Advanced eXtensible Interface 4 (AXI4) interconnect, and Xilinx Kintex-7 series Programmable Logic (PL) which provide the requisite capabilities for the increasing demands of embedded processing applications. The AMBA AXI4 interconnect provides high speed point to point interconnections between the ARM processor cores and the Field Programmable Gate Array (FPGA) structure allowing for rapid data transmission to optimize system performance. The incorporation of an RTOS ensures predictable execution times of applications. Benchmarks, such as the Rhealstone, were developed to provide designers with a method of evaluating and comparing these multitasking RTOSs running on various hardware platforms. This thesis research performs Rhealstone benchmarking and evaluates the AMBA AXI4 interconnect performance while executing FreeRTOS on the ARM core of the Zynq EPP device.
Temple University--Theses
Epp, Rebekka [Verfasser], i Marcus [Akademischer Betreuer] Fischer. "Das Phönomen der "frühen Repoliarisation" in einer adipösen Studienpopulation vor und nach einem professionellen Programm zur Gewichtsreduktion / Rebekka Epp ; Betreuer: Marcus Fischer". Regensburg : Universitätsbibliothek Regensburg, 2018. http://d-nb.info/1172071721/34.
Pełny tekst źródłaEpp, Konstantin [Verfasser], Roland A. [Akademischer Betreuer] Fischer, Vos Dirk [Gutachter] De i Roland A. [Gutachter] Fischer. "Metalloporphyrin-based Metal-Organic Frameworks as Multi-Functional Heterogeneous Catalysts / Konstantin Epp ; Gutachter: Dirk De Vos, Roland A. Fischer ; Betreuer: Roland A. Fischer". München : Universitätsbibliothek der TU München, 2019. http://d-nb.info/1188408879/34.
Pełny tekst źródłaBerg, Helena. "Defensiv stolthet : En fenomenologisk undersökning av stolthet i konflikter". Thesis, Stockholm University, Department of Psychology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6942.
Pełny tekst źródłaDefensiv stolthet kan få konflikter att uppkomma, trappas upp eller hindras från att lösas. En fenomenologisk undersökning genomfördes med syfte att identifiera vad defensiv stolthet, som fenomen, innebär. Frågeställningen löd; Vad konstituerar defensiv stolthet i konflikter? Resultatet baserades på 30 skriftliga protokoll samt fyra intervjuer. Analysen genomfördes enligt Karlssons EPP-metod. Undersökningen resulterade i en generell struktur som visar att den defensiva stoltheten är försvarsinriktad, känslomässig, social och centrerad runt individens självbild. Även en typologisk struktur framträdde och visade att den defensiva stoltheten i efterhand bedöms annorlunda beroende på om den anses verklighetsförankrad eller inte, samt att stoltheten går att motarbeta genom medveten ansträngning. Stolthetens inverkan på konflikten tenderar att vara pådrivande genom att den får konflikten att ta form av en kamp. I diskussionen kopplas resultatet till teorier från filosofiskt och psykoanalytiskt håll samt från emotions- och konfliktforskning.
Ström, Tobias, i My Kristensson. "Heldagslärande : hur det upplevs bland fritidslärare". Thesis, Malmö universitet, Malmö högskola, Institutionen för barndom, utbildning och samhälle (BUS), 2021. http://urn.kb.se/resolve?urn=urn:nbn:se:mau:diva-43685.
Pełny tekst źródłaSoares, Luana Barbosa. "Reflexo do Simples Nacional no recolhimento do ICMS das ME e EPP do Estado do CearÃ: uma anÃlise dos anos de 2004 a 2008". Universidade Federal do CearÃ, 2013. http://www.teses.ufc.br/tde_busca/arquivo.php?codArquivo=13715.
Pełny tekst źródłaO presente estudo buscou verificar o reflexo do Simples Nacional na arrecadaÃÃo do Imposto sobre CirculaÃÃo de Mercadorias e ServiÃos (ICMS) das Microempresas (ME) e Empresas de Pequeno Porte (EPP) cearenses. Para tanto se utilizou dados da arrecadaÃÃo do ICMS de 43.929 contribuintes do estado do Cearà pertencentes aos setores de agropecuÃria, indÃstria, meio ambiente, comÃrcio e serviÃos referente ao perÃodo de julho de 2004 a junho de 2008. Dessa maneira, mediante o emprego do modelo âDiferenÃa em DiferenÃaâ, os dados foram estimados e subdivididos nos grupos de tratamento e controle. No grupo de tratamento enquadraram-se as empresas que realizaram a opÃÃo pelo Simples Nacional, e no grupo de controle alocaram-se as empresas que, por algum motivo, nÃo realizaram a opÃÃo por esse programa governamental. Para analisar simultaneamente os efeitos do Simples Nacional relacionados Ãs atividades e Ãs caracterÃsticas dos setores as quais as empresas pertencem, estimou-se um modelo para os setores, subsetores e segmentos. A anÃlise dos dados sugere que o impacto da implantaÃÃo do Simples Nacional na arrecadaÃÃo do ICMS das empresas investigadas varia conforme o setor ao qual a empresa pertence.
The current paper aimed to investigate the impacts of âSimples Nacionalâ taxes in the collection of ICMS from Micro-Enterprises and Small Enterprises in the state of CearÃ. The study used historical data of ICMS from 43.929 taxpayers in the State of Cearà in Agricultural, Industrial, Environmental, Trade and Service sectors from July 2004 to June 2008, and throughout the application of âDifference to Differenceâ model, estimated and subdivided in a Case-Control study. For the case group, it was selected companies that opted for âSimples Nacionalâ; for the control group, companies that did not opt for it. In order to analyze simultaneously the effect of âSimples Nacionalâ in the level of the activities and characteristics within their corresponded sectors it was applied an estimation model for sectors, subsectors and segments. The data analysis suggests that the impact of National Simples in the ICMS collection from evaluated companies varies according to each sector they are part of.
Leiviskä, Deland Ann-Charlotte. "Det är något som inte stämmer : upplevelsen av psykos ur ett fenomenologiskt perspektiv". Thesis, Stockholm University, Department of Psychology, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-6928.
Pełny tekst źródłaSyftet var att ur ett fenomenologiskt perspektiv förstå vad det innebär att vara psykotisk. Sex personer med erfarenhet av psykos intervjuades och materialet analyserades med den fenomenologiska EPP (Empirical phenomenological psychological) metoden. Fyra teman identifierades som kännetecknande för den psykotiska upplevelsen: Kontroll i tillvaron speglar känslan av att tappa kontrollen och av att uppleva sig kontrollerad av andra. Det innefattar även upplevelsen att på ett magiskt sätt styra och kontrollera andra. Utanförskap beskriver hur förmågan till social interaktion försvinner i psykosen och hur känslan av ett djupt utanförskap dominerar. Självmedvetandet i psykosen beskriver upplevelsen av att något inte stämmer, hur psykosen anas men inte går att kommunicera. Upplöst tidslighet beskriver hur tillvaron känns meningslös genom att tidsupplevelsen förändras och strävan framåt försvinner. Resultaten pekar på vikten av att omgivningen lyhört registrerar individens signaler på att något är fel för att tidigt kunna upptäcka och hjälpa personer som riskerar att bli psykotiska.
Costa, José Ivandir da Silva. "Simples nacional: novo modelo de tributação das microempresas e empresas de pequeno porte". reponame:Repositório Institucional do FGV, 2010. http://hdl.handle.net/10438/8021.
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O presente estudo aborda o modelo Simples Nacional como diferencial de tributação aplicado as microempresas e empresas de pequeno porte com a finalidade de garantir maiores perspectivas de consolidação desses negócios no mercado, a partir de um tratamento tributário diferenciado. Tal mudança deu-se a partir das determinações do novo Código Tributário em vigor por meio da Lei Complementar nO. 123, da Microempresa (ME) e da Empresa de Pequeno Porte (EPP). Trata-se de um conjunto de normas que determinam um tratamento simplificado e favorecido aos pequenos negócios, conhecida no âmbito tributário como Simples Nacional ou 'Super Simples'. O estudo objetiva analisar a relevância do tratamento tributário diferenciado como forma de estimular o desenvolvimento desse segmento na economia nacional. Adotei como percurso metodológico para o estudo a pesquisa bibliográfica e documental, complementado por um estudo de caso realizado em empresa de pequeno porte na cidade de Belém. Verifica-se que a implementação do modelo Simples Nacional ainda está em fase de experimentações, não sendo possível ainda perceber vantagens significativas no desenvolvimento das microempresas e empresas de pequeno porte, contudo, é possível que se avance no sentido de minimizar as situações de informalidade. Conclui-se que mesmo com o tratamento tributário diferenciado aplicado as microempresas e empresas de pequeno porte, o Simples Nacional expressa vantagens e desvantagens para este setor produtivo.
Sundholm, Krister. "Den psykoanalytiska situationen : En fenomenologisk studie av analysandens upplevelse". Thesis, Stockholms universitet, Institutionen för pedagogik och didaktik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-95657.
Pełny tekst źródłaMoody, Brendon Dean. "Educator Preparation Provider Training and Technology Integration". University of Findlay / OhioLINK, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=findlay1565163638160558.
Pełny tekst źródłaBerretta, Andresa Aparecida. "Pesquisa pré-clínica e clínica de um gel termorreversível contendo extrato padronizado de própolis (EPP-AF) para a redução do tempo de cicatrização de lesões em pacientes queimados". Universidade de São Paulo, 2007. http://www.teses.usp.br/teses/disponiveis/60/60137/tde-03122008-164750/.
Pełny tekst źródłaThe present paper examines the pre-clinical and clinical evaluation of a pharmaceutical form that provides sustained delivery of a formulation containing standardized propolis extract EPP AF to the treatment of burn wounds. There has been used a polymer with thermoreversible characteristics which made possible the obtaintion of a product that maintains its liquid state in low temperatures and provides in situ gelling property. The proposed pharmaceutical form intends to enhance patients comfort and acceptance, to obtain a histological well-organized skin tissue and to reduce wound healing time. This study evaluated in vitro the antimicrobial activity of propolis extract and obtained gels using the agar-diffusion method and also a broth microdilution method with microdillution in microplates containing serially diluted antimicrobial and triphenilthetrazolium agent, against microorganisms S. aureus, M. luteus e P. aeruginosa, the mutagenic potential using micronuclei of peripheral blood Wistar rats experimental models, the histology of neo-formed tissue induced by lesions done with a punch and the effectiveness of the products in burn patients, using skin-grafting donnor sites like experimental models. The results show that propolis extract has activity against the listed microorganisms and that the gels did not spread into agar medium plate. In the microdilution method, the used model for the antimicrobial activity study is not adequate to the microorganism M. luteus, but it was possible for the obtention of CIM to S. aureus e P. aeruginosa, which were, respectively, 50 ug/mL e 200 ug/mL. The product did not show genotoxic potential to acute, subacute and chronic treatments. The clinical research show that the thermoreversible gel formulation containing standardized propolis extract 3,6%p/v presented wound healing time similar to the reference treatment used in the Burn Victims Unity witch is nitrofurazone cream (furacin®).
Durrant, Kate. "The Genetic and Social Mating System of a White-Backed Population of the Australian Magpie (Gymnorhina tibicen tyrannica)". Thesis, Griffith University, 2004. http://hdl.handle.net/10072/366788.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
Australian School of Environmental Studies
Full Text
Durrant, Kate, i n/a. "The Genetic and Social Mating System of a White-Backed Population of the Australian Magpie (Gymnorhina tibicen tyrannica)". Griffith University. Australian School of Environmental Studies, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20040716.093636.
Pełny tekst źródłaAristizabal, Castañeda Rayniero, Esquerre Jesús Richard Bernabé i Álvarez Nibardo Primero Cano. "Propuesta de mejora en la gestión de inventarios de los procesos vinculados a las compras internacionales, para reducir los inventarios de lento movimiento en una empresa de distribución de EPP (Equipo de Protección Personal)". Master's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2019. http://hdl.handle.net/10757/626356.
Pełny tekst źródłaThe main objective of this thesis work is to determine the causes of the slowly moving inventory and its possible solution, in a company dedicated to the commercialization of personal protective equipment. First, a brief introduction is developed, consisting of the presentation of the topic, the formulation of the problem, the approach of the general objective and the specific objectives, the initial hypothesis, and finally; the foundation and sustenance of carrying out this investigation. Next, the theoretical framework required for the adequate understanding and subsequent development of the research is detailed. The topics cover bibliographic and theoretical bases about inventories, warehouse management, supply chain and lean management. The current situation of the slow-moving detected inventory is analyzed, which at the end of 2015 represented 30% of the total warehouse inventory, then lean methodologies have been progressively implemented until this percentage is reduced to 10% at the end of 2018, the objective of the organization is to maintain a standard between 5% and 10%, in that sense and aligned to the processes of continuous improvement is expected at the end of 2019 reach 5%, taking into account that the increase in these inventories of slow movement they carry financial consequences that this company assumes, due to the policies of the top management of the organizational headquarters located in London, England. Then the opportunity for improvement is determined in the processes that have a greater impact on slow-moving inventories, through an ABC analysis to determine 20% of the stock that represents 80% of the cost; and implement, through methodologies suggested by Lean Management, strategies to reduce inventory with low turnover.
Trabajo de investigación
Danielson, Kathryn, i Sean Ustic. "Characterization of the Signaling Properties of FLAG Tagged EP2 and EP4 Prostanoid Receptors". The University of Arizona, 2009. http://hdl.handle.net/10150/623990.
Pełny tekst źródłaOBJECTIVES: To develop a novel characterization system utilizing immunofluorescent FLAG tagged EP2 and EP4 receptors to assist in the explanation of their unique cell signaling properties for exploitation in future drug development design. METHODS: Plasmids were obtained and isolated that contained cDNAs encoding FLAG-tagged EP2 and EP4 receptors for transient expression in HEK-293 cells. The sequences of these plasmids were confirmed by restriction enzyme analysis and DNA sequencing. Transfected cells were treated with vehicle, PGE2 or forskolin to assess appropriate receptor functionality based on cAMP induction. RESULTS: The two PGE2 receptor subtypes, EP2 and EP4, are similar in their activation of adenylyl cyclase (AC) and subsequent up regulation of cAMP production. These receptors differ, however, in that EP2 more efficiently stimulates cAMP production and EP4 signaling involves the activation of phosphatidylinositol 3-kinase (PI3K) and extracellular signal related kinases (ERKs). The PGE2- treated cells responded as predicted with intracellular production of cAMP, with the EP2 receptor responding more efficiently than the EP4 receptor. CONCLUSIONS: The intent is for these cells to be used as a novel assay system for the development of future selective EP2 and EP4 agonists. This research could potentially benefit in selectively targeting EP2 or EP4 pathways linked to prevalent ailments such as pain, fever, inflammation, possibly cancer or bone growth.
Avanzo, Sylvie. "Accompagnement à l'élaboration psychologique de la maternité. : problématiques et enjeux". Thesis, Lyon, 2016. http://www.theses.fr/2016LYSE2165.
Pełny tekst źródłaThe psychological accompaniment of motherhood is one area of development that has contributed to improve the quality and safety of perinatal care. The early prenatal interview of the fourth month (the EPP of the 4th month) is offered to all pregnant women and expectant parents, in order to initiate a dialogue and surface vulnerabilities. In my private practice as a psychologist, I have observed that several young mothers asking for accompaniment after delivery, suffer from a psychological pain and express a need for support, which were already present during their pregnancy, but which were not attended to by the midwife or doctor.Is the psychological dimension in the EPP, or during prenatal visits to the doctor, only taken into account in the case of pregnant women, whose fragility is obvious? Are the states of psychological discomfort felt by pregnant women, which are not obvious, but deserve a psychologist support, easily identified by the midwife or doctor during the EPP or prenatal visits? The answers to these questions are based on three following studies assessing: (a) the perceived usefulness of the EPP by expectant mothers who availed of it; (b) the way midwives lead the EPP; (c) the nature and causes of painful emotional states felt during pregnancy by some expectant mothers, who would have needed a support that did not materialize.Several recommendations are made to improve the response to the need for psychological support in pregnant women, some more suited to the hospital environment and others geared toward midwives and doctors operating in private practices
Thibodeau, Jean-François. "Prostaglandin E2 Signaling Through Kidney EP1 and EP4 Receptors; Implications in Diabetes and Hypertension". Thesis, Université d'Ottawa / University of Ottawa, 2015. http://hdl.handle.net/10393/32749.
Pełny tekst źródłaEpp, Tatjana [Verfasser], i Gregor [Akademischer Betreuer] Markl. "Halogen (F, Cl, Br, I) cycling in the critical zone : Formation of primary ore deposits, their supergene weathering and the fate of halogens in soil and along the hydrological flow path / Tatjana Epp ; Betreuer: Gregor Markl". Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1213720664/34.
Pełny tekst źródłaNobileau, Constance Médioni Michel. "Évaluation de la recherche des facteurs de risque cardiovasculaires en prévention primaire et en soins primaires à partir des résultats d'une évaluation des pratiques professionnelles (EPP) d'une association de formation médicale continue (FMC) de la ville de Créteil". Créteil : Université de Paris-Val-de-Marne, 2008. http://doxa.scd.univ-paris12.fr:80/theses/th0487208.pdf.
Pełny tekst źródłaReschke, Cristina Ruedell. "RECEPTORES EP1 E EP3 MODULAM AS CRISES EPILÉPTICAS INDUZIDAS POR PENTILENOTETRAZOL E ÁCIDO CAÍNICO EM CAMUNDONGOS". Universidade Federal de Santa Maria, 2013. http://repositorio.ufsm.br/handle/1/3852.
Pełny tekst źródłaEpilepsy is one of the most common neurologic disorders. It has been suggested that seizures may be facilitaded by inflammation. PGE2 is one of the most important inflammatory mediators, and facilitates pentylenetetrazol (PTZ)-induced seizures by stimulating EP1 and EP3 receptors. However, up to the present moment, no study has investigated whether EP1 and EP3 receptors blocking attenuate seizures induced by convulsants other than PTZ. It is also unknown whether Na+,K+-ATPase activity alterations are involved in such an effect. Therefore, in the current study we investigated whether EP1 and EP3 ligands (agonists and antagonists) modulate PTZ- and kainic acid (KA)-induced seizures, and whether alterations in Na+,K+-ATPase activity mediate such a protective effect, in mice. EP1 and EP3 antagonists (ONO-8713 and ONO-AE3-240, respectively, 10 Og/kg, s.c.) attenuated PTZ (60 mg/kg, i.p.)- and KA (20 mg/kg, i.p.)-induced seizures. The respective agonists (ONO-DI-004 and ONO-AE-248, 10 Og/kg, s.c.) facilitated seizures in both acute models, and at noneffective doses, prevented the protective effects of the antagonists. Animals injected with PTZ presented decreased Na+,K+-ATPase activity in the cerebral cortex and hippocampus. On the other hand, animals injected with KA presented increased Na+,K+-ATPase activity in the same cerebral structures at the end of the experiment. These divergent findings suggest that alterations in Na+,K+-ATPase activity in both acute models depends on the convulsant agent used and make difficult to establish a relationship between Na+,K+-ATPase activity and seizure development. Moreover, EP1 and EP3 antagonists administration abolished Na+,K+- ATPase activity alterations induced by PTZ and KA, in such a way that these alterations seem to be related more to the presence of ictal phenomenon itself than to the seizure induction mechanisms. Notwithstanding, the currrent results clearly show that EP1 and EP3 receptors might constitute novel targets for anticonvulsants development, since EP1 and EP3 decreased seizures, regardless of the convulsant agent used.
A epilepsia é uma das disfunções neurológicas mais comuns. Tem sido sugerido que as crises epilépticas podem ser facilitadas pela ocorrência de inflamação. A PGE2 é um dos mediadores inflamatórios mais importantes que, agindo por meio dos receptores EP1 e EP3, facilita as convulsões induzidas por pentilenotetrazol (PTZ). Contudo, até a presente data, nenhum estudo investigou, de maneira sistêmica, se a ativação ou bloqueio de receptores EP1 e EP3 facilitam as convulsões induzidas por outros agentes; tampouco se alterações na atividade da Na+,K+-ATPase estão envolvidas nesse efeito. Assim, no presente estudo, investigamos se ligantes (agonistas e antagonistas) de receptores EP1 e EP3 modificam as crises induzidas por PTZ e ácido caínico (KA), e se tais efeitos estão associados a alterações na atividade da enzima Na+,K+-ATPase, em camundongos. Os antagonistas EP1 e EP3 (ONO-8713 e ONO-AE3-240, respectivamente, 10 Og/Kg, s.c.) atenuaram as convulsões induzidas por PTZ (60 mg/Kg, i.p.) e KA (20 mg/Kg). Os seus respectivos agonistas (ONO-DI-004 e ONO-AE-248 de 10 Og/Kg, s.c.) facilitaram as convulsões em ambos modelos agudos de crises epilépticas e, em doses não efetivas para gerar crises, preveniram os efeitos dos antagonistas. Os animais submetidos à administração de PTZ apresentaram, ao final do experimento, a atividade Na+,K+-ATPásica diminuída no córtex cerebral e hipocampo. Por outro lado, animais tratados com KA apresentaram um aumento na atividade Na+,K+-ATPásica nestas mesmas estruturas, que se correlacionou positivamente com a vigência de status epilepticus no momento do sacrifício. Os achados divergentes no que diz respeito à alteração da atividade da Na+,K+-ATPase nos dois modelos de crises agudas sugere que tais alterações estejam relacionadas ao tipo de agente convulsivante utilizado, e dificultam estabelecer, de forma inequívoca, uma relação entre atividade desta ATPase e sensibilidade à crises agudas. Ademais, a administração de antagonistas EP1 e EP3 aboliu as alterações da atividade da Na+,K+-ATPase induzidas tanto por PTZ como por KA, de tal forma que estas parecem estar mais associadas com o fenômeno ictal em si, do que com os mecanismos de indução da crise. Contudo, os resultados mostram de forma clara que os receptores EP1 e EP3 podem se constituir possíveis novos alvos para o desenvolvimento de drogas antiepilépticas, pois antagonistas EP1 e EP3 diminuíram as crises, independente do agente convulsivante utilizado.