Gotowa bibliografia na temat „Epilepsy”
Utwórz poprawne odniesienie w stylach APA, MLA, Chicago, Harvard i wielu innych
Spis treści
Zobacz listy aktualnych artykułów, książek, rozpraw, streszczeń i innych źródeł naukowych na temat „Epilepsy”.
Przycisk „Dodaj do bibliografii” jest dostępny obok każdej pracy w bibliografii. Użyj go – a my automatycznie utworzymy odniesienie bibliograficzne do wybranej pracy w stylu cytowania, którego potrzebujesz: APA, MLA, Harvard, Chicago, Vancouver itp.
Możesz również pobrać pełny tekst publikacji naukowej w formacie „.pdf” i przeczytać adnotację do pracy online, jeśli odpowiednie parametry są dostępne w metadanych.
Artykuły w czasopismach na temat "Epilepsy"
1
Budiman, Marshen, Praevilia M. Salendu i Johnny L. Rompis. "Pengaruh Riwayat Kejang Demam terhadap Kejadian Epilepsi pada Anak". e-CliniC 11, nr 1 (10.10.2022): 19. http://dx.doi.org/10.35790/ecl.v11i1.37740.
Pełny tekst źródłaStreszczenie:
Abstract: Epilepsy could cause various kinds of problems including learning difficulties, growth and development disorders, and poor quality of life of children in the future. There are several risk factors of febrile seizures that coud affect the occurrence of epilepsy inter alia abnormalities of the nervous system or there is a clear development of nervous system abnormalities before the seizure, complex febrile seizures, history of epilepsy in parents or siblings, as well as simple febrile seizures repeating four or more episodes in one year. Each of these risk factors increases the likeli-hood of epilepsy, and the combination of these risk factors increases the incidence of epilepsy. This study aimed to determine the effect of a history of febrile seizures on the incidence of epilepsy in children. This was a literature review study using three databases namely Pubmed, ClinicalKey, and Google Scholar. The keywords used were febrile seizure AND epilepsy AND children. Selection with inclusion and exclusion criteria obtained 10 literatures. The results showed that from 10 literatures reviewed, history of febrile seizures was the most common risk factor that influenced the developing of epilepsy in later life. In conclusion, history of febrile seizures is the most common risk factor for developing epilepsy in children later in life. The percentage of children with history of febrile seizure that develop to epilepsy is 3.3% - 73.8%.Keywords: febrile seizures; epilepsy; children Abstrak: Epilepsi dapat menyebabkan berbagai macam permasalahan berupa kesulitan dalam belajar, gangguan pertumbuhan dan perkembangan, serta kualitas hidup yang kurang pada anak di masa depan. Terdapat beberapa faktor risiko kejang demam yang berperan terhadap terjadinya epilepsi, di antaranya: kelainan pada sistem saraf atau adanya perkembangan kelainan yang jelas sebelum kejang, kejang demam kompleks, riwayat epilepsi pada orang tua atau suadara kandung, dan kejang demam sederhana yang berulang empat episode atau lebih dalam satu tahun. Masing-masing faktor risiko tersebut meningkatkan kemungkinan kejadian epilepsi dan kombinasi faktor risiko tersebut akan meningkatkan kejadian epilepsi. Penelitian ini bertujuan untuk mengetahui pengaruh riwayat kejang demam terhadap kejadian epilepsi pada anak. Penelitian ini berbentuk literature review, menggunakan tiga database yaitu Pubmed, ClinicalKey, dan Google Scholar. Kata kunci yang digunakan yaitu febrile seizure AND epilepsy AND children. Hasil seleksi dengan kriteria inklusi dan eksklusi mendapatkan 10 literatur. Hasil penelitian menunjukkan bahwa dari sepuluh jurnal yang di-review, didapatkan riwayat kejang demam menjadi salah satu faktor risiko yang memiliki pengaruh untuk berkembang menjadi epilepsi di kemudian hari. Simpulan penelitian ini ialah riwayat kejang demam merupakan faktor risiko terbanyak untuk berkembang menjadi epilepsi pada anak di kemudian hari. Persentase anak dengan riwayat kejang demam yang berkembang menjadi epilepsi berkisar antara 3,3% - 73,8%.Kata kunci: kejang demam; epilepsi; anak
2
Tri Utami, Melinda, Refani Adisti Rahmadini, Adelia Putri, Damayanti, Sri Ana, Rian Dzikrianto i Yulia Hermawati. "REVIEW ARTIKEL : PENGGUNAAN OBAT ANTI EPILEPSI DI RUMAH SAKIT". Medimuh : Jurnal Kesehatan Muhammadiyah 4, nr 2 (28.12.2023): 113–18. http://dx.doi.org/10.37874/mh.v4i2.632.
Pełny tekst źródłaStreszczenie:
ABSTRAK
Epilepsi adalah gangguan pada sistem saraf pusat akibat pola aktivitas listrik yang berlebihan di otak (Rahmat, 2021). Epilepsi memerlukan pengobatan yang lama (Dewi, 2020). Kepatuhan minum obat akan mempengaruhi hasil pengobatan. Hal ini menyebabkan penderitanya mengalami kejang secara berulang pada sebagian atau seluruh tubuh. Tujuan penelitian ini untuk mengetahui penggunaan obat antiepilepsi di Rumah Sakit dan untuk mengetahui beberapaorang yang menderita epilepsi di berbagai kota di Indonesia. Metode penelitian yang digunakan dalam artikel ini dengan mengumpulan jumlah penelitian sebanyak 11 jurnal dari situs “Google Scholar” dengan kata kunci anti epilepsi, epilepsi, pengobatan anti epilepsi, penggunaan obat anti epilepsi.
Kata kunci : anti epilepsi, pengobatan antiepilepsi, epilepsi, penggunaan obat anti epilepsi.
ABSTRACT
Epilepsy is the use of disordes of the central nervous system due to excessive electrical activity patterns in the brain. Epilepsy requires prolonged treatment. Medication adherence will affect the outcome of treatment. This causes the sufferer to experience repeated seizures in parts or the whole body. The purpose of this study was to dertemine the use of anti-epileptic drugs in hospitals and to find out how many people suffer from epilepsy in various cities in Indonesia. The research method used in this article by collecting 11 research journals from the “Google Scholar” site with the keywords antidpilepticm,epilepsy, anti-epileptic medication, use of antiepileptic drugs.
Keywords: anti epilepsy, anti epileptic medication, epilepsy, use of anti-epileptic drugs
3
Budiman, Marshen, Praevilia M. Salendu i Johnny L. Rompis. "Pengaruh Riwayat Kejang Demam terhadap Kejadian Epilepsi pada Anak". e-CliniC 11, nr 1 (10.10.2022): 19–26. http://dx.doi.org/10.35790/ecl.v11i1.44268.
Pełny tekst źródłaStreszczenie:
Abstract: Epilepsy could cause various kinds of problems including learning difficulties, growth and development disorders, and poor quality of life of children in the future. There are several risk factors of febrile seizures that coud affect the occurrence of epilepsy inter alia abnormalities of the nervous system or there is a clear development of nervous system abnormalities before the seizure, complex febrile seizures, history of epilepsy in parents or siblings, as well as simple febrile seizures repeating four or more episodes in one year. Each of these risk factors increases the likeli-hood of epilepsy, and the combination of these risk factors increases the incidence of epilepsy. This study aimed to determine the effect of a history of febrile seizures on the incidence of epilepsy in children. This was a literature review study using three databases namely Pubmed, ClinicalKey, and Google Scholar. The keywords used were febrile seizure AND epilepsy AND children. Selection with inclusion and exclusion criteria obtained 10 literatures. The results showed that from 10 literatures reviewed, history of febrile seizures was the most common risk factor that influenced the developing of epilepsy in later life. In conclusion, history of febrile seizures is the most common risk factor for developing epilepsy in children later in life. The percentage of children with history of febrile seizure that develop to epilepsy is 3.3% - 73.8%.
Keywords: febrile seizures; epilepsy; children
Abstrak: Epilepsi dapat menyebabkan berbagai macam permasalahan berupa kesulitan dalam belajar, gangguan pertumbuhan dan perkembangan, serta kualitas hidup yang kurang pada anak di masa depan. Terdapat beberapa faktor risiko kejang demam yang berperan terhadap terjadinya epilepsi, di antaranya: kelainan pada sistem saraf atau adanya perkembangan kelainan yang jelas sebelum kejang, kejang demam kompleks, riwayat epilepsi pada orang tua atau suadara kandung, dan kejang demam sederhana yang berulang empat episode atau lebih dalam satu tahun. Masing-masing faktor risiko tersebut meningkatkan kemungkinan kejadian epilepsi dan kombinasi faktor risiko tersebut akan meningkatkan kejadian epilepsi. Penelitian ini bertujuan untuk mengetahui pengaruh riwayat kejang demam terhadap kejadian epilepsi pada anak. Penelitian ini berbentuk literature review, menggunakan tiga database yaitu Pubmed, ClinicalKey, dan Google Scholar. Kata kunci yang digunakan yaitu febrile seizure AND epilepsy AND children. Hasil seleksi dengan kriteria inklusi dan eksklusi mendapatkan 10 literatur. Hasil penelitian menunjukkan bahwa dari sepuluh jurnal yang di-review, didapatkan riwayat kejang demam menjadi salah satu faktor risiko yang memiliki pengaruh untuk berkembang menjadi epilepsi di kemudian hari. Simpulan penelitian ini ialah riwayat kejang demam merupakan faktor risiko terbanyak untuk berkembang menjadi epilepsi pada anak di kemudian hari. Persentase anak dengan riwayat kejang demam yang berkembang menjadi epilepsi berkisar antara 3,3% - 73,8%.
Kata kunci: kejang demam; epilepsi; anak
4
Kurnia, Bonar, Edward Nangoy i Jimmy Posangi. "Diet Ketogenik untuk Penyakit Epilepsi Resisten Obat". Jurnal Biomedik:JBM 13, nr 3 (10.04.2021): 282. http://dx.doi.org/10.35790/jbm.13.3.2021.31946.
Pełny tekst źródłaStreszczenie:
Abstract: Epilepsy is estimated to affect 70 people worldwide. Anti-epileptic drugs (AED) as the main therapy for epilepsy can treat epilepsy in 70% of patients but 20-30% of patients experience Drug-Resistant Epilepsy (DRE). One therapy that can be given to patients who are not responsive to AED is ketogenic diet, a diet high in fat, low in carbohydrates and sufficient protein, which can help control seizures. The mechanism of action is still not known, but it may relate to AED. This study aims to determine the role or effect of ketogenic diet for DRE. This research is in the form of a literature review. In this study, the ketogenic diet was found to be effective in treating DRE especially in reducing seizure frequency. Ketogenic diet is particularly effective in treating focal seizures and West syndrome, and the correlation between ketogenic diet and AED can be found in a theory of the mechanism of action of the ketogenic diet with the mechanism of action of AED which is the actual therapy of this epilepsy. Ketogenic diet is effective as an alternative therapy for DRE in infants to adults. What needs to be considered is the type of ketogenic diet used must be suitable for the patient in order to achieve the best adherence, tolerability and effectiveness. Classification of the patient's epilepsy such as the type of seizure or the etiology of the epilepsy may also be a factor in starting a ketogenic diet therapy.Keywords: Epilepsy, Refractory Epilepsy, Drug Resistant Epilepsy, Ketogenic Diet Abstrak: Epilepsi diperkirakan diderita oleh 70 orang di seluruh dunia. Obat anti epilepsi (OAE) sebagai terapi utama untuk epilepsi dapat menangani epilepsi pada 70% penderita namun 20-30% pasien mengalami Epilepsi Resisten Obat. Terapi yang dapat diberikan untuk pasien yang tidak responsif terhadap pemberian OAE adalah diet ketogenik, diet tinggi lemak, rendah karbohidrat dan cukup protein yang dapat membantu mengontrol bangkitan. Mekanisme kerja diet ketogenik masih belum diketahui namun kemungkinan ada kaitannya dengan OAE. Penelitian ini bertujuan untuk mengetahui peran atau efek diet ketogenik untuk penyakit epilepsi resisten obat. Penelitian ini berbentuk literature review. Dalam penelitian ini, diet ketogenik ditemukan efektif untuk menangani epilepsi resisten obat khususnya dalam menurunkan frekuensi bangkitan. Diet ketogenik secara khusus efektif dalam menangani bangkitan fokal dan sindrom west, dan korelasi antara diet ketogenik dengan OAE dapat ditemukan dalam teori mekanisme kerja diet ketogenik dengan mekanisme kerja OAE yang merupakan terapi sebenarnya epilepsi ini. Diet ketogenik efektif sebagai terapi alternatif untuk epilepsi resisten obat baik untuk pasien bayi hingga dewasa. Adapun yang perlu diperhatikan adalah jenis diet ketogenik yang digunakan harus sesuai dengan pasien guna mencapai ketaatan, tolerabilitas dan efektivitas yang terbaik. Klasifikasi epilepsi pasien seperti tipe bangkitan atau etiologi penyebab epilepsi dapat juga menjadi faktor pertimbangan untuk memulai terapi diet ketogenik.Kata Kunci: Epilepsi, Epilepsi Refrakter, Epilepsi Resisten Obat, Diet Ketogenik
5
Sari, Putu Ratih Padmarini Gantari, Dewi Sutriani Mahalini, I. Nyoman Budi Hartawan i Dyah Kanya Wati. "Tingkat kualitas hidup pasien anak epilepsi dengan QOLCE-16". Intisari Sains Medis 14, nr 3 (30.12.2023): 1249–53. http://dx.doi.org/10.15562/ism.v14i3.1908.
Pełny tekst źródłaStreszczenie:
Background: Epilepsy is defined clinically as unprovoked seizures lasting more than 24 hours. In Indonesia there are more than 700.000 to 1.400.000 cases of epilepsy with an increase of around 70,000 new cases every year. In addition, it is estimated that 40-50% occur in children. The level of quality of life of people with epilepsy is worth paying attention to because it is an indicator of the success of treating epilepsy sufferers. This research was conducted to determine the quality of life of pediatric epilepsy patients using an instrument, namely the quality of life in childhood epilepsy questionnaire-16 (QOLCE-16). Method: The research was conducted by conducting interviews with the patient's parents. Data presentation is carried out descriptively. Sample determination was carried out using the sample size formula for nominal data, with a minimum sample of 92 people. Results: Total of 93 samples that met the inclusion criteria, it was found that the majority of people with epilepsy were aged 6-11 years (44.09%), male (63.44%), with comorbidities (53.76%) , suffered from epilepsy for more than 3 years (62.37%). Apart from that, it was also found that the type of epilepsy most commonly suffered was generalized epilepsy (41.94%), the last education of the patient's parents was junior high school (48.39%) and the parents' income was below IDR 1,500,000-, (41, 94%). Conclusion: After conducting interviews with QOLCE-16, it was found that more samples had a low quality of life (61.29%). Latar Belakang: Epilepsi merupakan didefinisikan secara klinis sebagai kejadian kejang yang tidak terprovokasi yang menyerang lebih dari 24 jam. Di Indonesia terdapat lebih dari 700.000 sampai dengan 1.400.000 kasus epilepsi dengan pertambahan sekitar 70.000 kasus baru setiap tahunnya. Selain itu, diperkirakan 40-50% terjadi pada anak-anak. Tingkat kualitas hidup penyandang epilepsi patut diperhatikan karena merupakan salah satu indikator keberhasilan perawatan penderita epilepsy. Penelitian ini dilakukan untuk mengetahui kualitas hidup pasien anak epilepsi menggunakan sebuah instrument yaitu quality of life in childhood epilepsy questionnaire-16 (QOLCE-16). Metode: Penelitian dilakukan dengan cara melakukan wawancara dengan orang tua pasien. Penyajian data dilakukan secara deskriptif. Penentuan sampel dilakukan dengan rumus besar sampel untuk data nominal, dengan sampel minimal adalah 92 orang. Hasil: Dari 93 sampel yang memenuhi kriteria inklusi ditemukan bahwa terdapat paling banyak penderita epilepsi berada di usia 6-11 tahun (44,09%), berjenis kelamin laki-laki (63,44%), dengan komorbiditas (53,76%), menderita epilepsi selama lebih dari 3 tahun (62,37%). Selain itu, didapatkan juga bahwa tipe epilepsi yang paling banyak diderita adalah epilepsi umum (41,94%), pendidikan terakhir orang tua pasien adalah SMP (48,39%) serta penghasilan orang tua di bawah Rp 1.500.000-, (41,94%). Simpulan: Setelah dilakukan wawancara dengan QOLCE-16 didapatkan bahwa lebih banyak sampel yang memiliki kualitas hidup rendah (61,29%).
6
Sert, Havva, Serap Çetinkaya, Ahmet Seven i Meryem Pelin. "Knowledge levels of senıor nursing students about epilepsyHemşirelik son sınıf öğrencilerinin epilepsi hakkındaki bilgi düzeyleri". Journal of Human Sciences 14, nr 2 (30.05.2017): 1966. http://dx.doi.org/10.14687/jhs.v14i2.4532.
Pełny tekst źródłaStreszczenie:
Aim: This study was conducted to determine knowledge levels and the factors affecting of senior nursing students about epilepsy.Method: The study was conducted descriptively and cross-sectional between 17-27 January 2017 with 168 nursing senior students who agreed to participate in the study. The data was collected on social media with questionnaire which was composed of the literature review by the researchers. 15 of the questions were about socio-demographic characteristics and 20 of questions were about epilepsy. Analysing of data were carried out in a computer program by using percentage, Mann-Whitney U and Kruskal Wallis-H test.Results: It was determined that mean score of the students' knowledge level about epilepsy is 81,10±7,27. There was a statistically significant relationship between where they got the information about epilepsy, care a patient previously had a seizure and mean scores of epilepsy knowledge level (p<0,05). It was determined that students ,who got information about epilepsy from the health personnel and those who care a patient previously had a seizure, had high mean scores.Conclusion: In the study, ıt was determined that nursing senior students’ knowledge level about the epilepsy is high; where they got the information about epilepsy, care a patient previously had a seizure affects epilepsy knowledge.Extended English abstract is in the end of PDF (TURKISH) file. ÖzetAmaç: Bu çalışma, hemşirelik son sınıf öğrencilerinin epilepsi hakkındaki bilgi düzeylerini ve etkileyen faktörleri belirlemek amacıyla yapıldı.Gereç ve Yöntem: Çalışma, 17-27 Ocak 2017 tarihleri arasında çalışmaya katılmayı kabul eden 168 hemşirelik son sınıf öğrencisiyle tanımlayıcı ve kesitsel olarak yapıldı. Çalışmanın verileri sosyal medya aracılığı ile toplandı. Verilerin toplanmasında araştırmacılar tarafından literatür taranarak oluşturulan, 15’i sosyo-demogrofik özellikleri, 20’si epilepsi hakkında bilgi durumlarını ölçmeye yönelik sorudan oluşan soru formu kullanıldı. Veriler; bilgisayar ortamında, yüzdelik, Mann-Whitney U ve Kruskal Wallis-H testleri kullanılarak değerlendirildi.Bulgular: Öğrencilerin epilepsi bilgi düzeyleri toplam puan ortalamalarının 81,10±7,27 olduğu belirlendi. Öğrencilerin epilepsi hakkında bilgiyi nereden aldığı ve daha önce nöbet geçiren hastaya bakma durumları ile epilepsi bilgi düzeyi toplam puan ortalamaları arasında istatiksel olarak anlamlı ilişki olduğu saptandı (p<0,05). Sonuç: Çalışmada hemşirelik son sınıf öğrencilerinin epilepsi hakkındaki bilgi düzeylerinin yüksek olduğu; epilepsi hakkında bilgiyi nereden aldığı ve daha önce nöbet geçiren hastaya bakım vermenin epilepsi bilgi durumunu etkilediği belirlendi.
7
Ramadhan, Muhammad Fitra, Prastiya Indra Gunawa i Muhammad Arifin Parenrengi. "Faktor-Faktor Risiko Pasien Epilepsi Intraktabel pada Anak". Malahayati Nursing Journal 4, nr 12 (1.12.2022): 3321–34. http://dx.doi.org/10.33024/mnj.v4i12.7518.
Pełny tekst źródłaStreszczenie:
ABSTRACT Approximately 10.5 million children are diagnosed with active epilepsy worldwide, accounting for 25% of the world's population with epilepsy. Among 1 in 3 people who are diagnosed with epilepsy will develop intractable epilepsy, this means that regular and adequate treatment for 18 months does not show a decrease in the frequency and duration of seizures or has taken 2 anti-epileptic drugs but has not yet had an effect. The aim of this study was to analyze the risk factors that can cause intractable epilepsy in pediatric patients. This study used a retrospective observational research design with a systematic review approach, where all variable data were collected from previous studies. The collection of research data is collected from previous research data in the form of research journals collected from the scholar.google.co.id, NCBI, and science direct databases. The article search method uses the characteristics of PICO (Population, Intervention, Comparison, Outcome), then the data in the form of articles that have been collected are managed using the Preffered Reporting Items for Systematic Review and Meta-Analysis (PRISMA) method. Based on 9 articles that have been reviewed, it is found that there are no studies that include age as a risk factor for intractable epilepsy. Odds ratios for each risk factor varied, but the most studied risk factors in the study included in this study were developmental disorders (8/9), MRI / CT Scan (6/9), and status epilepticus (5/9). 9). From the results of this systematic review, the factors that most influence intractable epilepsy in children are developmental disorders with the highest odds ratio of 37.1 obtained in the study of Wirell et al. Gender factors, duration of seizure, family history of epilepsy, and history of febrile seizures did not significantly influence intactable epilepsy. In conclusion, this study found that the factors that most influence intractable epilepsy in children are developmental disorders and status epilepticus. Keywords: Risk Factors, Intractable Epilepsy, Children ABSTRAK Di seluruh dunia, sekitar 10,5 juta anak didiagnosis dengan epilepsi aktif, sebesar 25% dari populasi dunia dengan pengidap epilepsi. Diantara 1 dari 3 orang yang terdiagnosis epilepsi akan dapat berkembang menjadi epilepsi intraktabel, hal ini dapat diartikan bahwa pengobatan yang dilakukan selama 18 bulan secara teratur dan adekuat tidak menunjukkan penurunan frekuensi dan durasi kejang atau sudah mengonsumsi 2 obat anti epilepsi namun belum juga memberikan efek. Tujuan studi ini adalah untuk menganalisis faktor resiko yang dapat menyebabkan epilepsi intraktabel pada pasien anak. Penelitian ini menggunakan desain penelitian observasional retrospektif dengan pendekatan systematic review, dimana semua data variable dikumpulkan dari penelitian yang telah dilakukan sebelumnya. Pengumpulan data penelitian ini dikumpulkan dari data penelitian sebelumnya dalam bentuk jurnal penelitian yang dikumpulkan dari database scholar.google.co.id, NCBI, dan science direct. Metode pencarian artikel menggunakan karakteristik PICO (Population, Intervention, Comparison, Outcome) yang lalu data berupa artikel yang telah terkumpul dikelola dengan menggunakan metode Preffered Reporting Items for Systematic Review and Meta-Analysis (PRISMA). Berdasarkan 9 artikel yang telah dikaji, didapatkan bahwa tidak ada studi yang memasukkan faktor usia dalam sebagai faktor risiko epilepsi intraktabel. Odds ratio untuk masing-masing faktor risiko bervariasi, namun faktor risiko yang diteliti paling banyak pada studi yang diinklusi di penelitian ini adalah gangguan tumbuh kembang (8/9), MRI/CT Scan (6/9), dan status epileptikus (5/9). Dari hasil systematic review ini, faktor yang paling berpengaruh terhadap epilepsi intraktabel pada anak adalah gangguan tumbuh kembang dengan odds ratio tertinggi 37,1 yang didapatkan pada studi Wirell et al, dan status epileptikus dengan odds ratio 32,9 yang didapatkan pada studi Yildiz et al. Faktor jenis kelamin durasi waktu kejang, riwayat keluarga epilepsy, dan riwayat kejang demam tidak berpengaruh signifikan terhadap epilepsy intaktabel. Sebagai kesimpulan, dalam penelitian ini ditemukan faktor yang paling berpengaruh terhadap epilepsi intraktabel pada anak adalah gangguan tumbuh kembang dan status epileptikus. Kata Kunci: Faktor Risiko, Epilepsy Intraktabel, Anak
8
Putri, Derby Ayudhia Utami Iskandar, i Riri Gusnita Sari. "KARAKTERISTIK DAN TATALAKSANA SINDROM EPILEPSI: SEBUAH TINJAUAN LITERATUR". JURNAL RISET KESEHATAN POLTEKKES DEPKES BANDUNG 16, nr 1 (29.02.2024): 309–16. http://dx.doi.org/10.34011/juriskesbdg.v16i1.2525.
Pełny tekst źródłaStreszczenie:
Definisi dan klasifikasi sindrom epilepsi pertama kali disampaikan oleh International League Against Epilepsy (ILAE) tahun 1985. Menurut ILAE sindrom epilepsi merupakan gangguan epilepsi yang ditandai dengan sekelompok tanda dan gejala, yang dapat terjadi bersamaan. Gejala bergantung pada usia dan serangkaian penyakit penyerta tertentu. Penulis bertujuan menggabungkan berbagai literatur terkini mengenai sindrom epilepsi. Literatur diambil menggunakan database Google Scholar, PubMed, Cochrane Library dalam kurun waktu 4 (empat) tahun, 2019-2023. Studi yang diikutsertakan ke dalam literatur yang sesuai dengan kriteria inklusi meliputi studi yang menjelaskan mengenai sindrom epilepsi dan karakteristiknya. Klasifikasi sindrom epilepsi dibagi berdasarkan jenis kejang dan onset usia. Setiap jenis memiliki karakteristik dan tatalaksana yang berbeda. Sindrom epilepsi pada masa anak yang paling sering dijumpai meliputi, Generalized Tonic-Clonic Seizures Alone/ GTCSA, Childhood Absence Epilepsy/ CAE, Lennox-Gastaut Syndrome/ LGS, West syndrome/ WS, Self-Limited Childhood Epilepsy with Centrotemporal Spikes/ SLCECTS. Dapat disimpulkan bahwa inisiasi pengobatan antikejang pada sindrom epilepsi bergantung pada usia dan efektivitas yang berbeda dari obat antiepilepsi.
9
Saputra, Dedyanto Henky. "Peran Diet Ketogenik dalam Tata Laksana Epilepsi". Cermin Dunia Kedokteran 49, nr 11 (1.11.2022): 629–34. http://dx.doi.org/10.55175/cdk.v49i11.318.
Pełny tekst źródłaStreszczenie:
Sejak diperkenalkan pertama kali pada awal abad 19, penggunaan diet ketogenik dalam terapi epilepsi terus berkembang, khususnya untuk kasus epilepsi yang refrakter terhadap terapi farmakologi. Berbagai mekanisme terkait peran diet ketogenik dalam memperbaiki kondisi epilepsi telah diajukan, mulai keterlibatannya dalam regulasi GABA dan glutamat, efek antioksidan, perbaikan metabolisme energi, hingga koreksi kondisi disbiosis. Diet ketogenik adalah terapi non-farmakologis epilepsi yang menjanjikan, saat ini telah masuk dalam guideline NICE di Inggris untuk kasus epilepsi anak yang resisten terhadap terapi obat anti-epilepsi. Since its introduction in the early 19th century, ketogenic diet for the treatment of epilepsy is still being developed, especially for refractory cases. Various mechanisms have been proposed, ranging from its involvement in GABA and glutamate regulation, antioxidant effects, improvement of energy metabolism, to correction of dysbiosis conditions. Ketogenic diet is a promising non-pharmacological therapy for epilepsy; it has been included in UK NICE guidelines for pharmacologically-resistant pediatric epilepsy cases.
10
Fitriyani, Fitriyani, Firly Windiyani, Tusy Triwahyuni i Dharmawita Dharmawita. "TINGKAT PENGETAHUAN TENTANG PENYAKIT EPILESPI DAN PERTOLONGAN PERTAMA SAAT SERANGAN PADA MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS MALAHAYATI ANGKATAN 2019 DAN 2021". Jurnal Ilmu Kedokteran dan Kesehatan 10, nr 6 (10.07.2023): 2083–89. http://dx.doi.org/10.33024/jikk.v10i6.9427.
Pełny tekst źródłaStreszczenie:
Abstract: LEVELS OF KNOWLEDGE ABOUT EPILEPSY AND FIRST AID AT ATTACKS IN MEDICAL FACULTY OF MAHAYATI UNIVERSITY AT OF 2019 AND 2021 Epilepsy is a heterogeneous entity with a wide variety of etiologies and clinical features. Status epilepticus is a neurological emergency with morbidity and mortality depending on the duration of the seizure. Researchers want to measure the knowledge of the two batches of 2019 and 2021 because 2019 has taken the neurology block which has already discussed epilepsy, while 2021 has just passed the second semester and has not received epilepsy material in the neurology block. This study found out the Differences in Knowledge Levels of Medical Students Classes of 2019 and 2021 regarding epilepsy and first aid in patients with epilepsy who have seizures. This research is a quantitative study with a cross sectional approach. The population in the study were 142 medical students in the 2019 batch of Malahayati University in Bandar Lampung and 133 in 2021. So the total is 275, the sample is 164 students. Data collection using a questionnaire. Relationship analysis using independent t test. Research Results: Batch 2019 most of the respondents had knowledge in the good category 70 people (85.4%) with an average score of 27.7, Batch 2021 most of the respondents had knowledge in the sufficient category 45 respondents (54.9%) with an average score of 19.9. The statistical test results obtained a p value of 0.000. Conclusion: there are differences in knowledge about epilepsy and first aid for epilepsy patients between students of the 2019 and 2021 general medicine study programs Keywords: Knowledge, epilepsy, first aidAbstrak: TINGKAT PENGETAHUAN TENTANG PENYAKIT EPILEPSI DAN PERTOLONGAN PERTAMA SAAT SERANGAN PADA MAHASISWA FAKULTAS KEDOKTERAN UNIVERSITAS MALAHAYATI ANGKATAN 2019 DAN 2021 Epilepsi merupakan entitas heterogen dengan etiologi dan gambaran klinik yang sangat bervariasi. Status epileptikus merupakan suatu kondisi kegawatdaruratan neurologis dengan morbiditas dan mortalitas tergantung durasi bangkitan. Peneliti ingin mengukur pengetahuan dua angkatan 2019 dan 2021 dikarenakan 2019 telah mengambil blok neurologi yang sudah membahas penyakit epilepsi sedangkan 2021 baru melewati semester dua dan belum mendapatkan materi epilepsi di blok neurologi. Tujuan penelitian ini diketahui Perbedaan Tingkat Pengetahuan Mahasiswa Kedokteran Angkatan 2019 dan 2021 terhadap penyakit epilepsi dan pertolongan pertama pada pasien epilepsi yang kejang. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan cross sectional. Populasi pada penelitian adalah mahasiswa kedokteran Angkatan 2019 Universitas Malahayati Bandar Lampung sebanyak 142 dan angkatan tahun 2021 sebanyak 133. Jadi totalnya adalah 275, Sampel sebanyak 164 mahasiswa. Pengumpulan data menggunakan kuesioner. Analisis hubungan menggunakan uji t independen. Hasil Penelitian: Angkatan 2019 sebagian besar responden memiliki pengetahuan dalam kategori baik 70 orang (85.4%) dengan nilai rata-rata 27.7, Angkatan 2021 sebagian besar responden memiliki pengetahuan dalam kategori cukup 45 responden (54.9%) dengan nilai rata-rata 19.9. Hasil uji statistik diperoleh nilai p value 0,000. Kesimpulan: ada perbedaan pengetahuan tentang penyakit epilepsi dan pertolongan pertama pada pasien epilepsi antara mahasiswa prodi kedokteran umum angkatan 2019 dan 2021 Kata Kunci: Pengetahuan, penyakit epilepsi, pertolongan pertama
Rozprawy doktorskie na temat "Epilepsy"
1
Madeira, Bianca Cecchele. "Avaliação de uma ferramenta online para indicar pacientes candidatos à cirurgia da epilepsia". reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2015. http://hdl.handle.net/10183/139953.
Pełny tekst źródłaStreszczenie:
Introdução: A epilepsia é uma das condições mais comuns na prática neurológica. Sua prevalência na população em geral é expressiva (cerca de 2%). Dentre esses pacientes, existem aqueles que são fármaco-resistentes, ou seja aqueles que não atingem controle de suas crises com dois fármacos adequados de maneira otimizada, os quais correspondem a cerca de 20-40%. Esses pacientes apresentam um controle inadequado de sua condição crônica e o tratamento a longo prazo torna-se insatisfatório e de alto custo, sem levar em consideração a redução da qualidade de vida do paciente, o impacto psicossocial, as incapacidades e o risco aumentado de morte. Somando-se a isso, existe o fato de eles, muitas vezes, necessitarem de cuidadores, geralmente familiares, os quais, por consequência, também deixam de produzir. Sendo assim, é imperativo que tratamentos alternativos custo-efetivos sejam disponibilizados para esses pacientes. A cirurgia da epilepsia é uma opção muito adequada para pacientes selecionados, uma vez que ela pode melhorar substancialmente a qualidade de vida dos pacientes, em muitos casos fazendo até mesmo com que o paciente fique livre de crises, além da redução dos custos à longo prazo. O grande problema é anterior à cirurgia: reside no fato de existir uma certa dificuldade em identificar e encaminhar esses pacientes para uma avaliação adequada, seja por desconhecimento por parte dos médicos em geral, seja pela escassez de recomendações formais. Objetivos: Avaliar uma ferramenta online para indicar pacientes candidatos à cirurgia da epilepsia, colaborando, assim com uma maior facilidade para fins de tomada de decisão clínica com uma melhor identificação destes pacientes. Métodos: Realizamos um estudo transversal avaliando a indicação cirúrgica de pacientes com epilepsia focal, conforme testagem de uma ferramenta online disponível para este fim. Este trabalho foi realizado com pacientes consecutivos que frequentaram o Ambulatório de Epilepsia do Serviço de Neurologia do Hospital de Clínicas de Porto Alegre, no período de janeiro a abril de 2014. Todos os pacientes incluídos no estudo apresentavam o diagnóstico de epilepsia e suas informações foram retiradas da revisão de seus prontuários através de um questionário padronizado respondido pelos pesquisadores. As informações que porventura não constavam registradas em prontuário foram coletadas durante a consulta de rotina. No total, foram avaliados 211 pacientes. Resultados: No nosso estudo, primeiramente realizamos uma análise de prevalência, encontrando um resultado de 56,9% de pacientes com indicação à avaliação cirúrgica. Além disso, realizamos uma avaliação das variáveis que contribuem para a indicação ou não do tratamento cirúrgico. Nessa etapa, encontramos a frequência das crises, o número de fármacos testados e a presença de efeitos colaterais como as variáveis com maior significância estatística para indicação ao tratamento cirúrgico. Conclusão: Acreditamos que este trabalho possui grande relevância clínica por se tratar de uma ferramenta que pode ajudar na tomada de decisão para fins de tratamento, beneficiando, assim, pacientes e possivelmente reduzindo custos do sistema de saúde a médio e longo prazo.Background: Epilepsy is one of the most commons neurological conditions in practice. Its prevalence in the general population is significant (about 2%). Among these patients, there are those that are drug-resistant (those who do not achieve control of their seizures with two suitable drugs optimally), which correspond to about 20-40%. These patients have inadequate control of their chronic condition and long-term treatment becomes unsatisfactory and expensive, regardless of the reduced quality of life of patients, the psychosocial impact, disability and increased risk of death. In addition, the fact that they often need caregivers usually familiar, which, therefore, also fail to produce. It is therefore imperative that cost-effective alternative treatments are available for these patients. The epilepsy surgery is a suitable option for selected patients, since it can substantially improve the quality of life of patients, in many cases making even the patient seizure free, in addition to reducing costs in the long term. The big problem is before surgery: lies in the fact that there is some difficulty in identifying and referring these patients for proper evaluation, either by ignorance on the part of physicians in general, and the lack of formal recommendations. Objectives: Evaluate an online tool to nominate patients candidates for epilepsy surgery, thus contributing to a larger facility for the purposes of clinical decision-making with better identification of these patients. Methods: We conducted a cross-sectional study evaluating the surgical indication in patients with focal epilepsy, as testing of an online tool available for this purpose. This work was performed with consecutive outpatients attending at the Epilepsy Clinic of the Hospital de Clínicas de Porto Alegre, in the period of January-April 2014. All patients included in the study had a diagnosis of epilepsy and their information was taken from the review of their medical records using a standardized questionnaire answered by researchers. The informations who were not registered, were collected during a routine visit. In total, 211 patients were evaluated. Results: In our study, first we conducted a prevalence analysis, finding a result of 56.9% of patients referred for surgical evaluation. In addition, we conducted an evaluation of variables that contribute to the indication or not of surgical treatment. At this stage, we found the frequency of seizures, the number of tested drugs and the presence of side effects such as variables with greater statistical significance for indication for surgical treatment. Conclusion: We believe that this work has great clinical relevance because it is a tool that can help in decision making for treatment, thus benefiting patients and reducing health care costs in the medium and long term.
2
Räty, Lena. "Living with epilepsy : young people with uncomplicated epilepsy and adults with newly debuted epilepsy /". Linköping : Univ, 2002. http://www.bibl.liu.se/liupubl/disp/disp2003/med764s.pdf.
Pełny tekst źródła
3
Oliveira, Elton Pallone de. "Estudo crítico dos modelos experimentais em epilepsia espontânea do tipo ausência". Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/5/5160/tde-24052011-135103/.
Pełny tekst źródłaStreszczenie:
A epilepsia é uma das afecções neurológica mais comum na população mundial. Trata-se de uma condição crônica altamente incapacitante que acomete indivíduos de ambos os sexos e de todas as faixas etárias, com um discreto predomínio em homens e, maior freqüência em crianças abaixo de dois anos e idosos acima de 65 anos. As conseqüências de morbidade e mortalidade desta patologia repercutem negativamente na sociedade e, conseqüentemente na economia global. Estima-se que de 60 a 100 milhões de pessoas ao redor do mundo apresentaram alguma condição epiléptica durante suas vidas. Segundo alguns autores a incidência da epilepsia varia de 11 a 131/100 mil habitantes por ano e a prevalência de 1,5 a 30/1000 habitantes por ano, sendo que os maiores valores encontram-se nos países em desenvolvimento, particularmente na America Latina e na África. As epilepsias generalizadas idiopáticas (EGI) constituem-se cerca de um terço de todas as formas de epilepsias e são 15 a 20% mais freqüentes em relação aos demais tipos de epilepsia. As EGI do tipo ausência, as quais são estritamente relacionadas à faixa etária infantil e adolescente podem muitas vezes (2,8 5,7% dos casos) afetar pacientes com idade superior a 15 anos. A fisiopatologia, assim como, as causas reais da ocorrência e/ou recorrência das crises de ausência na idade adulta não estão completamente esclarecidos e se representam um importante desafio para os epileptologistas. As epilepsias generalizadas idiopáticas (EGIs), (etiologia genética) são classificadas em: a) crises de ausência típicas, b) crises de ausência atípicas, c) crises de ausência com fatores especiais, d) crises mioclônicas, e) crises mioclônicas atônicas, f) crises mioclônicas tônicas, g) crises clônicas, h) crises tônicas e, i) crises atônicas. O tratamento e comumente farmacológico e as crises são controladas na maioria dos casos, no entanto, cerca de um terço dos pacientes são refratários às drogas anticonvulsivantes. Tendo como principal finalidade a elucidação de mecanismos básicos e, auxílio no desenvolvimento de abordagens terapêuticas eficazes para esses pacientes, pesquisadores do mundo inteiro dedicam muitos esforços para o desenvolvimento de modelos experimentais capazes de mimetizar o fenômeno que se pretende reproduzir. Dentre os principais modelos experimentais em EGIs, pode-se citar: (1) o modelo de epilepsia generalizada induzida por penicilina em gatos; (2) modelos de investigação da bicuculina; (3) indução por estimulação elétrica; (4) ratos geneticamente epilépticos de Strasbourg (GAERS); (5) cepa WAG/Rij; (6) modelo do gama-hidroxibutirato (GHB) e (7) os camundongos mutantes. Tais modelos experimentais têm provido meios para que os pesquisadores possam avaliar e quantificar adequadamente as alterações neuronais que ocorrem durante os processos epileptógenos tanto in vitro ou in vivo, possibilitando importantes avanços no desenvolvimento de novas abordagens terapêuticas e, melhora na qualidade de vida de portadores de epilepsiaEpilepsy is a very commom neurological disorders in world population. It is a chronicle condition highly disabling that affects both genera male and female independent of your age with a soft predominance in men and is more frequent in child under 2 years old and adult above 65 years old. The morbidity and mortality consequences of this disorder have many negative repercussions at society and global economy consequently. It is estimated about 60 to 100 millions of people around the world present any epileptic condition during their lives. According some researchers the epilepsy incidence varies about 11 to 131/100 thousand habitants for year and the prevalence between 1.5 to 30/1000 habitants for year, about this statics the higher values are found in developing countries, Latin America and Africa particularly. The Idiopathic Generalized Epilepsy (IGE) are about a third of all others kinds of epilepsies and are 15 to 20% more frequent tha n others types of epilepsies. The absences IGEs are strictly related with childhood and adolescence age group and sometimes can affect patients (2.8 5.7 of cases) with age higher than 15 years old. The physiopathology as the real causes of to occur and to reoccur of absences crises in adult age are not completely enlightened and represent a important challenge to epileptlogists. The IGEs (genetic etiology) are classified in: a) typical absence seizures, b) atypical absence seizures, c) absence seizures with special factors, d) mioclonics seizures, f) tonic mioclonic seizures, g) clone seizures, h) tonic seizures and i) atonic seizures. The treatment commonly is pharmacologic and seizures are controlled in major parts of cases although about a third of patients are refratory to anticonvulsants drugs. Having as principal finality the elucidation of basic mechanisms and help of development of effectiv e therapeutical approaches to these patients, researchers around the world spend many efforts to develop experimental models able to reproduce the phenomena that want to reproduce. Among the principal experimental models of IGEs, it is possible to cite: (1) the general epilepsy model induced by penicillin in cats; (2) the models of investigation of bicuculin; (3) induction by electrical stimulation; (4) Genetic Absence Epilepsy Rats of Strasbourg (GAERS); (5) cepa WAG/Rij; (6) the model of gamma-hydroxybutyric (GHB) and (7) mutant rats. These experimental models have promoted ways to researchers can to evaluate and quantify adequately the neuronal alterations that occur during epileptigenes process both in vitro or in vivo, making possible important advances in development of new therapeutical approaches and improvement in quality of life of epilepsy carriers
4
Hendriks, Marc P. H. "Memory deficits in epilepsy patients referred to tertiary epilepsy centres". Maastricht : Maastricht : Universiteit Maastricht ; University Library, Maastricht University [Host], 2005. http://arno.unimaas.nl/show.cgi?fid=6293.
Pełny tekst źródła
5
Sprissler, Ryan Steven, i Ryan Steven Sprissler. "Genetics of Epilepsy". Diss., The University of Arizona, 2017. http://hdl.handle.net/10150/625894.
Pełny tekst źródłaStreszczenie:
Epilepsy, characterized primarily by seizures, is one of the most common forms of neurological dysfunction in humans. This dissertation will explore the genetic components and responses to seizures in both animal and human models. This will encompass different forms of seizure etiology including genetically derived channelopathies leading to generalized seizures as well as temporal lobe epilepsy with a wide rage of etiologies. Specific attention is paid to changes in the transcriptional profile of the hippocampus in these various forms of epilepsy before and after seizure activity.
6
Courville, Aaron. "Chaosmakers for epilepsy". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1999. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape8/PQDD_0003/MQ45985.pdf.
Pełny tekst źródła
7
Neri, Marina Liberalesso 1980. "Avaliação neuropsicológica de crianças com epilepsia rolândica = funções executivas". [s.n.], 2012. http://repositorio.unicamp.br/jspui/handle/REPOSIP/309169.
Pełny tekst źródłaStreszczenie:
Orientadores: Marilisa Mantovani Guerreiro, Catarina Abrão GuimarãesTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-19T22:11:29Z (GMT). No. of bitstreams: 1 Neri_MarinaLiberalesso_D.pdf: 1266603 bytes, checksum: 21ed75ba94dfafe79f7d15127e020891 (MD5) Previous issue date: 2012
Resumo: A epilepsia benigna da infância com pontas centrotemporais (EBIPCT) ou rolândica (ER) é a forma mais freqüente de epilepsia na infância e é classificada como sendo focal, genética e de evolução benigna. Apesar de não haver déficit intelectual, essas crianças podem apresentar alterações cognitivas específicas. O presente estudo teve como objetivos: identificar e descrever alterações de funções executivas em crianças com ER e verificar a influência de variáveis clínicas da epilepsia nas funções executivas. Os participantes foram submetidos à aplicação de testes de funções executivas. Foram incluídas crianças com diagnóstico clínico e eletroencefalográfico de ER. A maioria dos pacientes estava controlada e muitos deles encontravam-se sem medicação. Os resultados obtidos foram comparados com os de um grupo de crianças de um grupo-controle (GC) constituído de indivíduos normais, com idade e nível sócio-educacional semelhantes ao das crianças com epilepsia. Os dados coletados nos dois grupos foram analisados e comparados através dos testes estatísticos: Mann-Whitney, teste Qui-quadrado e teste Exato de Fisher. Os resultados mostraram que quanto aos dados numéricos crianças com ER obtiveram pior desempenho em cinco das seis categorias consideradas do Wisconsin Card Sorting Test (WCST): nº de erros, nº de erros perseverativos, nº de respostas perseverativas, nº de categorias completadas e nº de fracassos em manter o set. Considerando-se resultados categóricos crianças com ER obtiveram pior desempenho no Trail Making Test (TMT) parte B, no Teste de fluência verbal FAS e em três categorias do WCST: nº de erros, nº de erros perseverativos e nº de respostas perseverativas. Em relação à variável idade de início da epilepsia, crianças com início mais precoce apresentaram pior desempenho em um dos instrumentos utilizados quando comparadas com crianças com início mais tardio da epilepsia; em relação às demais variáveis da epilepsia, não foi possível qualquer tipo de análise; quanto às variáveis das crises, não houve diferença nos resultados obtidos pelos pacientes divididos em grupos. Diante desses resultados concluímos que: as crianças com ER apresentaram déficit em funções executivas quando comparadas com o grupo-controle; a bateria utilizada mostrou-se adequada para detecção das disfunções apresentadas pelas crianças com ER; em relação à variável da epilepsia idade de início, crianças com início mais precoce apresentaram pior desempenho do que crianças com início mais tardio da epilepsia; em relação às demais variáveis da epilepsia e às variáveis das crises, não houve diferença entre os dois grupos. Assim, nosso estudo segue a linha de raciocínio de que o termo benigno deve ser usado com cautela uma vez que nossos pacientes apresentaram déficits neuropsicológicos em funções executivas, independentemente da fase ativa da epilepsia e do uso de medicações
Abstract: The benign childhood epilepsy with centrotemporal spikes (EBIPCT) or rolandic epilepsy (RE) is the most common type of childhood epilepsy and is considered to be a focal, genetic and benign epilepsy. Although there is no intellectual deficit, these children may have specific cognitive impairments. This study aimed: to identify and describe changes in executive functions in children with RE and to verify the influence of clinical variables of epilepsy in executive functions. Participants were evaluated with tests to assess executive functions. We included children with clinical and EEG features of RE. Most patients were controlled and several were without medication. The results were compared with those of a control group (CG) comprised of normal subjects with age and socioeconomic level similar to that of the RE group. The data collected from both groups were analyzed and compared using statistical tests: Mann-Whitney, Chi-square and Fisher exact tests. The results showed that concerning the numerical data, children with RE had the worst performance in five of the six categories of the WCST: number of errors, number of perseverative errors, number of perseverative answers, number of completed categories and number of failures to maintain the set. Considering categorical results, children with RE had worse performance in Trail Making Test part B, Verbal fluency test FAS and three categories of the WCST: number of errors, number of perseverative errors and number of perseverative answers. Concerning the variable age of onset of epilepsy, children with earlier onset of epilepsy had a worse performance in one of the tools when compared with children with later onset of epilepsy; the other variables of epilepsy did not allow any analysis; considering seizure variables, there was no difference between the two groups. We conclude that: children with RE showed deficits in executive functions when compared with the control group; the set of tests was adequate to detect the dysfunctions presented by children with RE; in relation to the variable age of onset of epilepsy, children with earlier onset had a worse performance than children with later onset of epilepsy; concerning other epilepsy and seizure variables, there was no difference between the two groups. Thus, our study is in keeping with the idea that the term benign should be cautiously used since our patients had neuropsychological deficits in executive functions regardless of the active phase of epilepsy and the use of medications
Doutorado
Ciencias Biomedicas
Doutor em Ciências Médicas
8
Rocha, Renata Pina. "Epilepsia reflexa evacuatória: revisão de literatura e descrição de caso clínico com registro de crise ao vídeo-eletroencefalograma". Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/17/17160/tde-25042018-161435/.
Pełny tekst źródłaStreszczenie:
Introdução: a epilepsia reflexa é uma condição na qual todas as crises são desencadeadas por um estímulo específico e, na grande maioria dos casos, apresenta-se com crises refratárias ao tratamento. São vários os fatores desencadeantes, entre os quais se destaca pela raridade a evacuação. Objetivos: realizar revisão de literatura sobre epilepsia reflexa, identificar a evacuação como possível fator desencadeador de crise epiléptica e relatar o caso de um paciente com crise reflexa evacuatória documentada à monitorização por vídeo-eletroencefalograma Métodos: revisão de literatura acerca de epilepsias reflexas e revisão de prontuário de um paciente com suspeita clínica de epilepsia reflexa evacuatória. Resultados: o paciente deste estudo, um menino de 10 anos de idade, com dominância manual esquerda, iniciou, aos 4 anos, crises associadas à evacuação. Na monitorização por vídeo-eletroencefalograma, durante episódio de evacuação, apresentou parada comportamental, desvio cefálico para a direita, automatismos em membro superior esquerdo e arresponsividade, coçando o nariz tardiamente com a mão esquerda. O EEG ictal demonstrou atividade rítmica teta em região temporal esquerda com posterior envolvimento frontal esquerdo e de áreas homólogas contralaterais. As ressonâncias magnéticas de encéfalo não evidenciaram alterações e o SPECT interictal identificou hipoperfusão discreta na porção anterior do lobo temporal esquerdo. Com uso de ácido valpróico e carbamazepina o paciente segue livre de crises. Avaliações neuropsicológicas e de qualidade de vida sugerem comprometimento global, tanto antes como após o controle da epilepsia. Conclusão: este é apenas o terceiro caso de epilepsia reflexa evacuatória descrito na literatura, e o segundo com crises dessa ordem documentadas por vídeo-eletroencefalograma. Ambos sugeriram lateralização e localização em região temporal esquerda, elegendo esta região como potencial zona epileptogênica. O tratamento com ácido valpróico e carbamazepina mostrou-se eficaz para controle de crises neste paciente, podendo ser uma opção de tratamento em outros pacientes com este tipo de epilepsia.Background: Reflex epilepsy is a condition in which all seizures are triggered by a specific stimulus. There are many known stimulus, including defecation which has rarely been reported. In the majority of cases, it presents with refractory seizures. Objective: review the literature on reflex epilepsy, as well as identify defecation as a possible trigger and report a case of a patient with reflex seizures triggered by defecation documented by video-electroencephalogram monitoring. Methods: literature review on reflex epilepsies and review of medical records of a patient with reflex epilepsy triggered by defecation. Results: we present a 10-year-old-boy patient, left-handed, whose epilepsy onset was at the age of four. Its seizures were characterized by episodes of loss of consciousness and atonia during defecation. Video-electroencephalogram monitoring had shown a seizure triggered by defecation, characterized by right head deviation, left upper limb automatisms, associated with consciousness impairment and afterwards nose wiping with the left hand. The ictal EEG demonstrated theta rhythmic activity in the left temporal lobe. The brain magnetic resonance was normal. The interictal SPECT identified left anterior temporal lobe mild hypoperfusion. The patient became seizure free after the treatment with valproic acid and carbamazepine. Neuropsychological and quality of life assessments suggested global impairment, before and after seizure control. Conclusion: this is the third case of epilepsy induced by defecation, and the second with seizures documented by videoelectroencephalogram. Similar to this case, both had suggested lateralization and localization over the left temporal region, suggesting this region as a potential epileptogenic zone in patients with this type of reflex epilepsy. In our patient, the treatment with valproic acid and carbamazepine was effective for the seizure control and may be an option to other patients with this condition.
9
Kemper, Birgit. "Neuropsychologische Untersuchung bei Frontallappenepilepsien ein Vergleich kognitiver Leistungen zwischen Patienten mit Frontal- und Temporallappenepilepsie im Rahmen der prächirurgischen Diagnostik /". Münster : Universität Münster, 1995. http://catalog.hathitrust.org/api/volumes/oclc/64528329.html.
Pełny tekst źródła
10
Santos, Renato Oliveira dos. "Investigando o papel de genes candidatos na epilepsia do lobo temporal mesi = genes PTPRM e IL1B = Investigating candidates genes in mesial temporal lobe epilepsy : PTPRM and IL1B genes". [s.n.], 2015. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312709.
Pełny tekst źródłaStreszczenie:
Orientadores: IÍscia Teresinha Lopes Cendes, Cláudia Vianna Maurer-MorelliTese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas
Made available in DSpace on 2018-08-27T14:57:39Z (GMT). No. of bitstreams: 1 Santos_RenatoOliveirados_D.pdf: 1790615 bytes, checksum: 5e996ae5810a67103c553e7bdc08ecc8 (MD5) Previous issue date: 2015
Resumo: As epilepsias formam um grupo de doenças neurológicas crônicas caracterizadas por crises epilépticas, as quais podem ser definidas como um distúrbio intermitente do sistema nervoso causado por descarga elétrica anormal, súbita e sincronizada dos neurônios cerebrais. A epilepsia de lobo temporal (ELT) é a mais frequente, representando aproximadamente 50% dos casos em adultos e tem como manifestação típica, a crise parcial complexa. Além disso, é frequentemente refratária ao tratamento medicamentoso. Os principais sintomas gerados pela ELT são predominantemente pelo acometimento das estruturas mediais do lobo temporal, sendo a ELT mesial (ELTM), a forma mais comum de ELT. Atualmente é ainda controversa a participação de fatores genéticos contribuindo na etiologia das epilepsias, principalmente da ELTM, que não teve até hoje nenhum gene inequivocamente associado a sua predisposição. O objetivo deste trabalho foi investigar o papel de dois genes candidatos: o PTPRM e o IL1B na predisposição à ELTM. Para tanto utilizamos as seguintes modalidades de estudo em pacientes com ELTM (i) estudo de associação genética através da genotipagem de polimorfismos de nucleotídeo único (SNPs) localizados nos referidos genes candidatos (esta etapa do estudo foi realizada durante o mestrado); (ii) quantificação dos transcritos de ambos os genes, por PCR em tempo real em tecido das estruturas mediais do lobo temporal (principalmente hipocampo) que foi obtido através da realização de cirurgia para tratamento das crises refratárias. (iii) Para o PTPRM, foi também realizada a localização do transcrito pela técnica de hibridação "in situ" em tecido hipocampal de pacientes e de controle. Além disso, como existem evidências do envolvimento do PTPRM em etapas importantes do desenvolvimento cerebral, e pouco se conhece da função específica desse gene no cérebro realizamos (iv) a quantificação do transcrito de PTPRM durante o desenvolvimento em cérebro de camundongos. (v) Finalmente, com o objetivo específico de avaliar se o aumento de expressão de IL1B no tecido hipocampal se refletia também na circulação realizamos a quantificação do transcrito e proteica do IL1B no plasma de pacientes com ELTM. Nossos resultados revelaram associação genética entre SNPs localizados em ambos os genes investigados e o fenótipo estudado. No entanto, em nenhum dos estudos uma variante funcional pode ser identificada. A quantificação dos transcritos em tecido hipocampal dos pacientes com ELTM indicou que ambos os genes PTPRM e IL1B estão hiper-regulados em pacientes quando comparados ao tecido controle. Não identificamos variação significativa na expressão do transcrito de PTPRM no cérebro de camundongos nas diferentes etapas de desenvolvimento. Não identificamos variação significativa na quantificação do transcrito e proteica de IL1B no plasma dos pacientes com ELTM quando comparados aos controles. Em conclusão, nossos resultados dos estudos de associação indicam um papel de PTPRM e de IL1B na predisposição à ELTM, porém não fomos capazes de encontrar uma variante funcional associada ao fenótipo. Corroborando o papel de ambos os genes nosso estudo de expressão gênica no tecido acometido indicou um aumento de expressão de ambos os genes. No entanto, o aumento de expressão de IL-1beta no tecido hipocampal não se traduziu pelo aumento no plasma dos pacientes. Finalmente, nosso estudo do perfil de expressão de PTPRM durante o desenvolvimento cerebral não aponta para um papel desse gene em etapas específicas do desenvolvimento
Abstract: The epilepsies are a group of chronic neurological disorders characterized by seizures, which can be defined as an intermittent disorder caused by an abnormal and sudden electrical discharge of neurons in the brain. Temporal lobe epilepsy (TLE) is the most frequent form, representing approximately 50% of cases in adults, and it is often refractory to drug treatment. The main symptoms in TLE are generated by the involvement of the medial temporal lobe structures, characterizing mesial TLE (MTLE). The contribution of genetic factor to MTLE it is still controversial and to date, no gene has been unequivocally associated with the predisposition to MTLE. Therefore, the aim of this study was to investigate the role of two candidate genes: PTPRM and IL1B in the predisposition to MTLE. To achieve this we use the following type study modalities in patients with MTLE (i) genetic association study by genotyping of single nucleotide polymorphisms (SNPs) located in these two candidate genes; (ii) quantification of the transcripts of both genes by real-time PCR in hippocampal tissue obtained from epilepsy surgery for the treatment of refractory seizures. (iii) For PTPRM we also performed in situ hybridization experiments in order to localize the transcript in hippocampal tissue from patients and controls. Furthermore, since there is evidence that PTPRM could be involved in key stages of brain development and little is known about the specific role of this gene in the brain, we performed (iv) quantification of its transcript during development in mouse brain. (v) Finally, with the specific objective of assessing whether the increase of IL1B expression in hippocampal tissue was also seen outside the central nervous system we quantified IL1B transcript and protein in plasma of patients with MTLE. Our results revealed genetic association between SNPs located in both genes and the phenotype. The quantification of transcripts in hippocampal tissue of patients with MTLE indicated that both genes are hyper-regulated when compared to control tissue. We did not find any significant variation in transcript expression of PTPRM in mouse brain during developed. In addition, no difference in transcript expression and protein levels of IL1B was observed in plasma of patients with MTLE. In conclusion, our results indicate an involvement of PTPRM and IL1B in the predisposition to MTLE; however, we are unable to find a functional variant associated with the phenotype. Corroborating the role of both genes in MTLE gene expression in affected tissue (hippocampus) indicated an up-regulation of both genes. However, the increase in IL1B expression in hippocampal tissue was not reflected by an increase of transcript or protein in plasma of patients with MTLE. Finally, our expression profile of PTPRM during brain development does not point to a role for this gene in specific stages of development
Doutorado
Fisiopatologia Médica
Doutora em Ciências
Książki na temat "Epilepsy"
1
Parkinson, Gill. Epilepsy. New York, NY: Continuum, 2006.
Znajdź pełny tekst źródła
2
Bazil, Carl W. Epilepsy. New York: Oxford University Press, 2011.
Znajdź pełny tekst źródła
3
McGowen, Tom. Epilepsy. New York: F. Watts, 1989.
Znajdź pełny tekst źródła
4
Krishnamoorthy, Ennapadam S., Simon Shorvon i Steven Schachter, red. Epilepsy. Cambridge: Cambridge University Press, 2017. http://dx.doi.org/10.1017/9781139547918.
Pełny tekst źródła
5
Miller, John W., i Howard P. Goodkin, red. Epilepsy. Oxford: John Wiley & Sons, 2014. http://dx.doi.org/10.1002/9781118456989.
Pełny tekst źródła
6
McCandless, David W. Epilepsy. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4614-0361-6.
Pełny tekst źródła
7
Service, Royal College of General Practitioners Library and Information. Epilepsy. London: The College, 1986.
Znajdź pełny tekst źródła
8
Parks, Peggy J. Epilepsy. San Diego, CA: ReferencePoint Press, 2009.
Znajdź pełny tekst źródła
9
Hopkins, Anthony. Epilepsy. New York, NY: Demos Publications Inc, 1987.
Znajdź pełny tekst źródła
10
Johnstone, Gary. Epilepsy. London: Boxtree, 1995.
Znajdź pełny tekst źródłaCzęści książek na temat "Epilepsy"
1
Berg, Charles. "Epilepsy and Hystero-Epilepsy". W Clinical Psychology, 195–208. London: Routledge, 2021. http://dx.doi.org/10.4324/9781003251514-16.
Pełny tekst źródła
2
Öztürk, Şerefnur. "Epilepsy". W Neurological Disorders in Clinical Practice, 25–31. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-23168-6_4.
Pełny tekst źródła
3
Reilly, Colin, i Christopher Gillberg. "Epilepsy". W Comorbid Conditions Among Children with Autism Spectrum Disorders, 235–56. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-19183-6_10.
Pełny tekst źródła
4
Mahmoud, Sherif Hanafy. "Epilepsy". W Patient Assessment in Clinical Pharmacy, 225–34. Cham: Springer International Publishing, 2019. http://dx.doi.org/10.1007/978-3-030-11775-7_17.
Pełny tekst źródła
5
Hilton, David A., i Aditya G. Shivane. "Epilepsy". W Neuropathology Simplified, 113–17. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-14605-8_8.
Pełny tekst źródła
6
Gilbert, Patricia. "Epilepsy". W The A-Z Reference Book of Childhood Conditions, 70–76. Boston, MA: Springer US, 1995. http://dx.doi.org/10.1007/978-1-4899-7098-5_16.
Pełny tekst źródła
7
Hattier, Megan A., Lauryn M. Toby i Lindsey W. Williams. "Epilepsy". W Comorbid Conditions in Individuals with Intellectual Disabilities, 195–236. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-15437-4_7.
Pełny tekst źródła
8
El-Hagrassy, Mirret M., Ana C. Texeira-Santos i Felipe Fregni. "Epilepsy". W Neuromethods, 445–517. New York, NY: Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7880-9_13.
Pełny tekst źródła
9
Lee, Dong Soo, So Won Oh i Myung-Chul Lee. "Epilepsy". W Clinical PET and PET/CT, 139–50. New York, NY: Springer New York, 2012. http://dx.doi.org/10.1007/978-1-4419-0802-5_12.
Pełny tekst źródła
10
Lehtimäki, Kai, i Jukka Peltola. "Epilepsy". W Fundamentals and Clinics of Deep Brain Stimulation, 235–47. Cham: Springer International Publishing, 2020. http://dx.doi.org/10.1007/978-3-030-36346-8_15.
Pełny tekst źródłaStreszczenia konferencji na temat "Epilepsy"
1
Sethi, P. K., i Nitin K. Sethi. "Epilepsy and Armed Forces". W 20th Joint Annual Conference of Indian Epilepsy Society and Indian Epilepsy Association. Thieme Medical and Scientific Publishers Private Ltd., 2018. http://dx.doi.org/10.1055/s-0039-1694888.
Pełny tekst źródła
2
Agarwal, Ekta, S. Rajadhyaksha, K. Srivastava i V. Kulkarni. "Three Staged Epidemiological Survey of Pediatric Epilepsy in a Rural Suburb of Pune". W 20th Joint Annual Conference of Indian Epilepsy Society and Indian Epilepsy Association. Thieme Medical and Scientific Publishers Private Ltd., 2018. http://dx.doi.org/10.1055/s-0039-1694857.
Pełny tekst źródła
3
C., Soumya V., i Ramshekhar N. Menon. "Evolution of Electroclinical Characteristics of West Syndrome: A Hospital Based Retrospective Study". W 20th Joint Annual Conference of Indian Epilepsy Society and Indian Epilepsy Association. Thieme Medical and Scientific Publishers Private Ltd., 2018. http://dx.doi.org/10.1055/s-0039-1694858.
Pełny tekst źródła
4
U., Saraf U., Asranna A., Menon R. N., Radhakrishnan A., Manju P., Vibina V. P., Cherian A. i Thomas S. V. "Electroclinical Predictors of Cognitive and Seizure Outcome in Children with Epileptic Encephalopathy Due to Electrical Status Epilepticus in Sleep (ESES)". W 20th Joint Annual Conference of Indian Epilepsy Society and Indian Epilepsy Association. Thieme Medical and Scientific Publishers Private Ltd., 2018. http://dx.doi.org/10.1055/s-0039-1694859.
Pełny tekst źródła
5
Chawla, Archita, Rajinder Bansal, Suman Sharma, Namita Bansal, Gagandeep Singh, Chirag Gupta i Karan Chouhan. "An Ethnographic and Structured Assessment of Treatment-Seeking Attitudes and Behaviors of People with Epilepsy in the Community". W 20th Joint Annual Conference of Indian Epilepsy Society and Indian Epilepsy Association. Thieme Medical and Scientific Publishers Private Ltd., 2018. http://dx.doi.org/10.1055/s-0039-1694860.
Pełny tekst źródła
6
Srivastava, Arpna, Aparna Dixit, Ramesh Dodamanni, Jyotirmoy Banerjee, Manjari Thipathi i P. Sarat Chandra. "Expression Profile of Histone Deacetylases in Patients with Hippocampal Sclerosis". W 20th Joint Annual Conference of Indian Epilepsy Society and Indian Epilepsy Association. Thieme Medical and Scientific Publishers Private Ltd., 2018. http://dx.doi.org/10.1055/s-0039-1694861.
Pełny tekst źródła
7
Kulkarni, Chanda, Ranjana G. i G. R. K. Sarma. "An Evaluation of Factors Influencing Adherence to Antiepileptic Medications (AEDs): A Cross-sectional Hospital-Based Study—An Overview and Recommendations to Improve". W 20th Joint Annual Conference of Indian Epilepsy Society and Indian Epilepsy Association. Thieme Medical and Scientific Publishers Private Ltd., 2018. http://dx.doi.org/10.1055/s-0039-1694862.
Pełny tekst źródła
8
D., Chavan M., Karamthoti M. B. i Kurra S. B. "Third Generation Cardioselective Beta Blocker Exhibits Significant Anticonvulsant Properties in Pentylenetetrazole Model in Wistar Albino Rats". W 20th Joint Annual Conference of Indian Epilepsy Society and Indian Epilepsy Association. Thieme Medical and Scientific Publishers Private Ltd., 2018. http://dx.doi.org/10.1055/s-0039-1694863.
Pełny tekst źródła
9
D., Chavan M., Karamthoti M. B. i Kurra S. B. "Na+-K+-2Cl– Cotransport Inhibitors and their Effect on Induced Seizure Tests in Experimental Models". W 20th Joint Annual Conference of Indian Epilepsy Society and Indian Epilepsy Association. Thieme Medical and Scientific Publishers Private Ltd., 2018. http://dx.doi.org/10.1055/s-0039-1694864.
Pełny tekst źródła
10
Gupta, Chirag, Gagandeep Singh, Karan Chouhan, Archita Chawla, R. K. Setia, Suman Sharma i Namita Bansal. "Correlation between Distance from Health Centre and Adherence to Clinic Appointments and Medication Procurement among People with Epilepsy in the Community". W 20th Joint Annual Conference of Indian Epilepsy Society and Indian Epilepsy Association. Thieme Medical and Scientific Publishers Private Ltd., 2018. http://dx.doi.org/10.1055/s-0039-1694865.
Pełny tekst źródłaRaporty organizacyjne na temat "Epilepsy"
1
Jiang, Huabei. Photoacoustic Imaging of Epilepsy. Fort Belvoir, VA: Defense Technical Information Center, kwiecień 2014. http://dx.doi.org/10.21236/ada607157.
Pełny tekst źródła
2
Lin, Ching-Yi. Magnetic Stimulation and Epilepsy. Fort Belvoir, VA: Defense Technical Information Center, październik 2013. http://dx.doi.org/10.21236/ada611602.
Pełny tekst źródła
3
Jiang, Huabei. Photoacoustic Imaging of Epilepsy. Fort Belvoir, VA: Defense Technical Information Center, kwiecień 2010. http://dx.doi.org/10.21236/ada613888.
Pełny tekst źródła
4
Jiang, Huabei. Photoacoustic Imaging of Epilepsy. Fort Belvoir, VA: Defense Technical Information Center, kwiecień 2013. http://dx.doi.org/10.21236/ada576914.
Pełny tekst źródła
5
Jiang, Huabei. Photoacoustic Imaging of Epilepsy. Fort Belvoir, VA: Defense Technical Information Center, kwiecień 2012. http://dx.doi.org/10.21236/ada587641.
Pełny tekst źródła
6
Jiang, Huabei. Photoacoustic Imaging of Epilepsy. Fort Belvoir, VA: Defense Technical Information Center, kwiecień 2011. http://dx.doi.org/10.21236/ada549242.
Pełny tekst źródła
7
Girisankar Prema, Abinaya, Iyshwarya Bhaskar Kalarani i Ramakrishnan Veerabathiran. Genetic aspects of epilepsy. Peeref, listopad 2022. http://dx.doi.org/10.54985/peeref.2211p2734634.
Pełny tekst źródła
8
Artac, Kaitlin. Catamenial Epilepsy: A Review. Ames (Iowa): Iowa State University, maj 2023. http://dx.doi.org/10.31274/cc-20240624-345.
Pełny tekst źródła
9
Phongsavanh, Assua. Epilepsy: an uncurable disease? Ames (Iowa): Iowa State University, styczeń 2021. http://dx.doi.org/10.31274/cc-20240624-631.
Pełny tekst źródła
10
Dichter, Marc A. Preventing Epilepsy After Traumatic Brain Injury. Fort Belvoir, VA: Defense Technical Information Center, luty 2008. http://dx.doi.org/10.21236/ada485727.
Pełny tekst źródła