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McDowell, David W. "Determining entrainment rate and the role of entrainment in stratocumulus clouds". Thesis, Monterey, Calif. : Springfield, Va. : Naval Postgraduate School ; Available from National Technical Information Service, 1999. http://handle.dtic.mil/100.2/ADA366842.
Pełny tekst źródła"June 1999". Thesis advisor(s): Wing Wang. Includes bibliographical references (p. 63-65). Also available online.
Dwivedi, Ambuj. "Mechanics of sediment entrainment". Thesis, University of Auckland, 2010. http://hdl.handle.net/2292/5854.
Pełny tekst źródłaGilani, Mohammad Nejad Hamzeei. "CFD of droplet entrainment". Thesis, Imperial College London, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.542939.
Pełny tekst źródłaStone, Rebecca E. "Deep mixed layer entrainment". Monterey, California. Naval Postgraduate School, 1997. http://hdl.handle.net/10945/8198.
Pełny tekst źródłaA bulk turbulence-closure mixed layer model is generalized to allow prediction of very deep polar sea mixing. The model includes unsteady three- component turbulent kinetic energy budgets. In addition to terms for shear production, pressure redistribution, and dissipation, special attention is devoted to realistic treatment of thermobaric enhancement of buoyancy flux and to Coriolis effect on turbulence. The model is initialized and verified with CTD data taken by R/V Valdivia in the Greenland Sea during winter 1993-1994. Model simulations show (1) mixed layer deepening is significantly enhanced when the thermal expansion coefficient's increase with pressure is included; (2) entrainment rate is sensitive to the direction of wind stress because of Coriolis; and (3) the predicted mixed layer depth evolution agrees qualitatively with the observations. Results demonstrate the importance of water column initial conditions, accurate representation of strong surface cooling events, and inclusion of the thermobaric effect on buoyancy, to determine the depth of mixing and ultimately the heat and salt flux into the deep ocean. Since coupling of the ocean to the atmosphere through deep mixed layers in polar regions is fundamental to our climate system, it is important that regional and global models be developed that incorporate realistic representation of this coupling
Spolander, Bruce John. "Entrainment in Saldanha Bay". Master's thesis, University of Cape Town, 1996. http://hdl.handle.net/11427/19819.
Pełny tekst źródłaSaldanha Bay is located lOOkm north of Cape Town, along the south western coast of South Africa, at a latitude of approximately 33° S. In 1975 major harbour works, including the construction of an iron ore jetty, divided Saldanha Bay into two distinct bays. The bay to the north of the jetty has become known as Small Bay, while the bay to the south is commonly referred to as Big Bay. Big Bay is connected at its southern end to the shallow Langebaan Lagoon system, and to the west with the Benguela upwelling system (see figure 1.1). The oceanography of the shelf outside the bay is dominated by the coastal upwelling system (Shannon 1985). The equatorward winds which predominate for much of the year, drive an offshore flux of surface water, which is replaced near the coast by nutrient-rich water from deeper layers. These winds are the result of an interplay between the South Atlantic High Pressure Cell, a thermal low that forms over southern Africa in summer, coastal lows, and eastward moving extra tropical cyclones (Shannon 1985). In summer, the band of extra tropical cyclones associated with the jetstream moves to the south of its winter position, while the South Atlantic High intensifies and moves approximately 6° to the south (Preston-Whyte and Tyson 1988), creating a pressure gradient over the Benguela region. The presence of the thermal low over the adjacent subcontinent increases the existing pressure gradient, and enhances the equatorward air flow. This seasonal modulation of upwelling favourable winds results in an upwelling season that extends from about September to March (Shannon 1985). During this period, there is also synoptic modulation, provided by wind relaxation or reversal events. These events are either associated with the passage of a cyclone to the south of the continent, or with a coastal low passing along the coast (Shannon 1985).
Chen, Chi-Shao. "Equatorial entrainment zone simulations". Thesis, Monterey, California : Naval Postgraduate School, 1990. http://handle.dtic.mil/100.2/ADA237234.
Pełny tekst źródłaThesis Advisor(s): Garwood, Roland W. Second Reader: Chu, Pecheng. "June 1990." Description based on signature page as viewed on October 19, 2009. DTIC Identifier(s): Air water interactions, ocean models, ocean currents, entrainment, ocean circulation, heat flux, wind velocity, mathematical prediction, equatorial regions, theses. Author(s) subject terms: Air-sea interaction, equatorial circulation. Includes bibliographical references (p. 73-75). Also available in print.
Huang, Danlan. "Entrainment in Pulsing plumes". Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/21168.
Pełny tekst źródłaThompson, Keith B. "Entrainment Zone Characteristics and Entrainment Rates in Cloud-Topped Boundary Layers from DYCOMS-II". Thesis, Monterey, California. Naval Postgraduate School, 2012. http://hdl.handle.net/10945/6881.
Pełny tekst źródłaBoga, Gabriele. "Numerical Experiments on Turbulent Entrainment". Master's thesis, Alma Mater Studiorum - Università di Bologna, 2020. http://amslaurea.unibo.it/20559/.
Pełny tekst źródłaLohmann, Frank Cord. "Entrainment processes during plume ascent". [S.l.] : [s.n.], 2006. http://e-diss.uni-kiel.de/diss_1693/d1693.pdf.
Pełny tekst źródłaSingh, Jaswant. "Gas entrainment by liquid sprays". Thesis, University of Leeds, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.432173.
Pełny tekst źródłaSmith, Karen Lynn. "Entrainment of the circadian clock". Thesis, University of Cambridge, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.624358.
Pełny tekst źródłaPilippu, Hewage Eranga Dulanjalee. "Erosion and entrainment during landslides". Thesis, The University of Sydney, 2022. https://hdl.handle.net/2123/28901.
Pełny tekst źródłaMc, Laughlin Declan T. "Gas entrainment into viscous polymer solutions". Thesis, Queen's University Belfast, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.252316.
Pełny tekst źródłaRigobon, Daniel E. "Models of entrainment of human walking". Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119940.
Pełny tekst źródłaCataloged from PDF version of thesis.
Includes bibliographical references (pages 39-40).
Stable human locomotion may be described as a non-linear limit cycle oscillator. This claim has been supported through the observation of dynamic entrainment and phase-locking to external mechanical perturbations applied at the ankle. Simple models have been developed in attempts to understand these behaviors, but have been unsuccessful at replicating experimental studies. In this manuscript, an energy-based controller was implemented on a single degree-of-freedom model, adjusting its leading leg angle at heel strike and consequently the energy dissipation of the model. Stochasticity was applied to the controller to simulate the variability which has been observed and quantified in walking. The results indicate that energy control may be responsible for entrainment in human walking, but a revised model may be required to match the experimental coefficients of variation in step duration and velocity.
by Daniel E. Rigobon.
S.B.
Beard, Robert L. "Oceanic mixed layer entrainment zone dynamics". Thesis, Monterey, California : Naval Postgraduate School, 1990. http://handle.dtic.mil/100.2/ADA240896.
Pełny tekst źródłaThesis Advisor(s): Garwood, R. W. Second Reader: Chu, P. C. "September 1990." Description based on title screen viewed on December 16, 2009. DTIC Descriptor(s): Marine meteorology, thermoclines, thickness, production, predictions, models, energy, theses, turbulence, temperature gradients, vertical orientation, heating, kinetic energy, budgets, oceans, weather stations, entrainment, north pacific ocean, shear properties, transients. DTIC Identifier(s): Mixed layer (marine) air sea interaction, entrainment shear production, mixed layer. Author(s) subject terms: air-sea interaction, entrainment shear production, mixed layer. Includes bibliographical references (p. 46-47). Also available in print.
Bahner, Mark A. "A reduced-turbulence, reduced-entrainment electrostatic precipitator". Thesis, This resource online, 1990. http://scholar.lib.vt.edu/theses/available/etd-03122009-040702/.
Pełny tekst źródłaWlodarczak, Marcin [Verfasser]. "Temporal entrainment in overlapping speech / Marcin Wlodarczak". Bielefeld : Universitätsbibliothek Bielefeld, 2014. http://d-nb.info/1047666359/34.
Pełny tekst źródłaHancock, Peter. "Metal entrainment in continuous liquid phase drosses". Thesis, McGill University, 1994. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=28772.
Pełny tekst źródłaExperiments were performed in which particle beds of $ gamma$-phase ($ rm Ag sb5Zn sb8$) intermetallic compound were infiltrated with liquid lead under controlled conditions and examined under the optical microscope. Image analysis revealed pronounced swelling of fine particle beds relative to coarse. The effect was most noticeable for average particle diameters less than 100 $ mu$m where the solids volume fraction decreased from 50 to 30 vol.%. Data showed samples LO exhibit a constant increase in inter-particle spacing of approximately 50 $ mu$m. The increase in spacing explained the degree of swelling at low particle diameters and was also used to develop an expression to predict height of capillary rise.
Based on an osmotic pressure analogy in colloidal particle systems, a swelling pressure term was defined to explain the increase in inter-particle spacing. The swelling pressure was defined as equal and opposite to the capillary pressure tending to force particles to random packing. It was concluded that swelling was related to mass transfer at the solid-liquid interface of the intermetallic crystals giving a reduced static pressure due to a localized minimization of Gibbs energy. The static pressure change (swelling pressure) was attributed to overlap of mass transfer boundary layers where mid-point static liquid metal pressure is less than the pressure in the bulk liquid. For the system studied, the mass transfer boundary layer was estimated to be approximately 100 $ mu$m in thickness.
Further experiments, using the sessile drop technique, were used to support the study findings by showing rapid spreading of liquid lead on Ag-Zn intermetallic substrates. The rapid spreading was attributed to mass transfer at the solid-liquid interface giving a reduced interfacial energy, $ gamma sb{ rm s1}$ due to a localized reduction in Gibbs energy.
The analysis of experimental results led to the development of two new industrial processes in the lead industry aimed at reducing lead loss to silver and bismuth crusts. Tests employing continuous agitation during bismuth removal from lead promoted the growth of large $ rm CaMg sb2Bi sb2$ crystals. The larger crystals minimized the effect of mass transfer boundary layer overlap and reduced lead entrainment from 90 to 80 volume percent. The addition of a low melting point KCl-ZnCl$ sb2$ salt during silver crust formation was found to remove up to 90% of entrained lead by the salt preferentially wetting Ag-Zn intermetallic particles. This was found to eliminate surface forces which retained liquid in the system of solid particles.
Harrison, Roger. "Entrainment of Air into Thermal Spill Plumes". Thesis, University of Canterbury. Civil and Natural Resources Engineering, 2009. http://hdl.handle.net/10092/2865.
Pełny tekst źródłaBalaji, Ravishankar. "Breathing Entrainment and Mechanical Ventilation in Rats". Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1307743446.
Pełny tekst źródłaBouvet, Cécile. "Auditory-motor entrainment : behavioural and cerebral dynamics". Thesis, Montpellier, 2020. http://www.theses.fr/2020MONT4002.
Pełny tekst źródłaWe often synchronise our movements to auditory rhythms in our environment without the intention to do so. Such coordination influences the stability of movement performance, and, therefore, can be used to our benefit in sport and therapeutic contexts. Research to date has largely reached a consensus about the mechanisms underlying intentional sensory-motor coordination, but spontaneous auditory-motor entrainment is still under exploration. This thesis addresses the dynamics of unintentional synchronisation towards various frequency relationships between periodic movement and auditory rhythm frequencies. It presents four complementary studies questioning the role of multiple metrical levels and their accentuation on the emergence and stability of simple vs. complex synchronisation in healthy adults. The 1st study confirms quantitatively the emergence of spontaneous synchronisation at frequency ratios different from 1:1. The 2nd study introduces the benefit of a congruent accentuation pattern on the emergence of various frequency ratios. It leads to the observation that a ternary accentuation pattern facilitates synchronisation more than a binary accentuation pattern. The 3rd study examines this new finding through the recording of neural responses to various accented patterns using Electroencephalography, confirming a differential response to ternary and binary patterns linked to behavioural performance. The 4th study focuses on the benefit of accentuation patterns for the production of a more complex type of movement coordination. It also measured neural tracking of the accentuation pattern relative to the congruence of the motor coordination performed, showing that both sensory and motor systems influenced rhythm perception. All together, these results demonstrate that spontaneous auditory-motor entrainment can emerge at various frequency ratios in accordance with the predictions of the dynamical systems approach to action and perception. Furthermore, spontaneous auditory-motor entrainment is modulated (i.e., increased or decreased) by the addition of simple accentuation patterns, depending on congruence with the auditory-motor frequency mode and the neural response to the accents. In addition, more complex multi-limb motor coordination performance responds similarly to accentuation, underpinned by auditory-motor coupling and sensory processing of the auditory rhythms. Therefore, the findings of this thesis open new avenues for future research on spontaneous auditory-motor coordination and its application in the training and rehabilitation of motor performance
Awin, Layth Ali M. "Structure and Entrainment of Forced Turbulent Fountains". Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/27276.
Pełny tekst źródłaHadjerioua, Boualem. "Air entrainment and oxygenation by overfalling nappes". Diss., The University of Arizona, 1994. http://hdl.handle.net/10150/186852.
Pełny tekst źródłaMartín, Buldú Javier. "Entrainment of semiconductor lasers : noise, modulation and synchronization". Doctoral thesis, Universitat Politècnica de Catalunya, 2003. http://hdl.handle.net/10803/6603.
Pełny tekst źródłaSi queremos resumir los resultados de esta tesis ordenados cronológicamente,debemos empezar hablando de ruido. El efecto de el ruido en un sistema no-lineal puede ser de gran ayuda en la obtención de una respuesta más regular, efectos como la resonancia coherente o la resonancia estocástica han dado buena prueba de ello. Con el objetivo de observar ambos fenómenos en el comportamiento pulsado de un láser en régimen de LFF, se realizan simulaciones numéricas a partir del modelo de Lang-Kobayashi (LK), que describe la evolución del campo eléctrico y los portadores en un LS. Los resultados obtenidos demuestran que añadiendo cierta cantidad de ruido externo a través de la corriente de bombeo, los pulsos observados en la intensidad de salida se vuelven más regulares, que es la característica típica de la resonancia de coherencia (RC). Si la corriente de bombeo está modulada con una señal periódica de cierta frecuencia, se puede observar cómo el ruido externo ayuda al sistema a seguir dicha frecuencia, lo que se refleja en la intensidad de salida con unas caídas no sólo más regulares, sino también a la frecuencia de forzamiento. Este fenómeno, observado en diversos sistemas no-lineales, se conoce como resonancia estocástica (SR). Los estudios realizados permiten observar que no sólo la amplitud del ruido es importante, sino también su tiempo de correlación, debiéndose ajustar ambos parámetros para poder observar dichas resonancias. En relación con el efecto del ruido en estos sistemas, se estudia (experimental y numéricamente) el caso de un láser en LFF cuando es modulado con dos frecuencias, observando resonancia a frecuencias no presentes en el sistema. Estos resultados son la primera evidencia experimental de este fenómeno, bautizado como resonancia fantasma (GR), el cual sólo habia sido predicho teóricamente hasta el momento.
Paralelamente, se analizan los efectos del acoplamiento de dos sistemas caóticos, en nuestro caso dos láseres en régimen de LFF. Los resultados demostran que el acoplamiento puede incrementar la respuesta de un sistema no lineal a un señal periódica externa.
Se profundiza también en el estudio del comportamiento multimodo de los láseres de semiconductor con realimentación óptica. Se presentan resultados experimentales y numéricos del comportamiento de los modos longitudinales en el régimen de LFF, observándose como, cuando la intensidad total cae, se activan modos laterales que hasta el momento permanecian apagados. Finalmente, y continuando con el estudio de la dinámica multimodo, se analiza la sincronización de dos láseres multimodo mediante una extensión del modelo de LK, observándose sincronización generalizada y anticipada, tanto de la intensidad total, como entre los modos longitudinales de cada láser. Estos resultados sugieren la utilización de este tipo de láseres para la transmisión de mensajes multiplexados.
Veverka, Peter John. "An investigation of interfacial instability during air entrainment". Diss., Georgia Institute of Technology, 1995. http://hdl.handle.net/1853/5800.
Pełny tekst źródłaBhutani, Supriya. "Natural entrainment of the drosophila melanogaster circadian clock". Thesis, University of Leicester, 2009. http://hdl.handle.net/2381/7881.
Pełny tekst źródłaBarrack, Duncan. "Modelling cell cycle entrainment during cortical brain development". Thesis, University of Nottingham, 2010. http://eprints.nottingham.ac.uk/11318/.
Pełny tekst źródłaMaa'd, Abdil-Ghani Shehab. "Entrainment and boiling limits in the heat pipe". Thesis, University of Reading, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.283274.
Pełny tekst źródłaWhyte, Kenneth K. "Entrainment and mixing in rivers, estuaries and reservoirs". Thesis, University of Liverpool, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.400129.
Pełny tekst źródłaJackson, Derek William Thomas. "Aeolian entrainment of surface beach and dune settlements". Thesis, University of Ulster, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.242047.
Pełny tekst źródłaWilliams, Jonathan Jowett. "Aeolian entrainment thresholds in a developing boundary layer". Thesis, Queen Mary, University of London, 1986. http://qmro.qmul.ac.uk/xmlui/handle/123456789/28966.
Pełny tekst źródłaSeidel, Tobias, Dirk Lucas i Matthias Beyer. "TOPFLOW-Experiments on Direct Condensation and Bubble Entrainment". Helmholtz-Zentrum Dresden - Rossendorf, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:d120-qucosa-197715.
Pełny tekst źródłaTerrill, Eric J. "Acoustic measurements of air entrainment by breaking waves /". Diss., Connect to a 24 p. preview or request complete full text in PDF format. Access restricted to UC campuses, 1998. http://wwwlib.umi.com/cr/ucsd/fullcit?p9907829.
Pełny tekst źródłaGalvanin, Silvia. "Circadian Clock Study Through Frequency-Encoded Entrainment Stimulations". Doctoral thesis, Università degli studi di Padova, 2018. http://hdl.handle.net/11577/3422301.
Pełny tekst źródłaI ritmi circadiani sono meccanismi biologici di organizzazione temporale intrinseci e autosostenuti, che consentono agli organismi di anticipare i cambiamenti ambientali e permettono loro di adattare il loro comportamento e la loro fisiologia nell’arco della giornata. L’orologio circadiano è sincronizzato dai cicli luce/buio e dall’ora dei pasti. La funzione biologica essenziale del ritmo circadiano è mantenere lo stato fisiologico dell’organismo e la sua sincronia comportamentale e metabolica con l’ambiente esterno. Recentemente è stato dimostrato che l’orologio circadiano garantisce il mantenimento dell’omeostasi metabolica, e che una distruzione del ritmo circadiano è causa di numerose malattie. L’approccio sperimentale convenzionale per lo studio dell’orologio circadiano in vitro è basato su una singola stimolazione di un solo metabolita o ormone, mentre in vivo i tessuti sono esposti in continuo a stimoli oscillatori periodici di una grande vastità di metaboliti e ormoni, le cui variazioni sono spesso interconnesse, come nel caso di glucosio e insulina. Inoltre, nell’analisi sperimentale convenzionale, sono studiati solo uno o pochi geni noti per essere implicati nell’orologio circadiano, mentre è noto che un elevato numero di geni sono espressi in modo circadiano. Lo scopo di questo progetto di ricerca è quindi sviluppare tecnologie e metodi di analisi per studiare l’effetto di stimoli metabolici in frequenza sull’orologio circadiano di tessuti periferici. Questi stimoli riproducono infatti in vitro le oscillazioni metaboliche a cui i tessuti sono esposti in vivo. Tecnologie, e più nello specifico, microtecnologie sono state sviluppate per studiare gli effetti di stimoli metabolici oscillatori, ed è stato dimostrato che in fibroblasti murini l’espressione di Per2 (uno dei geni principali del meccanismo molecolare dell’orologio circadiano) è sincronizzata da stimoli metabolici oscillatori. Inoltre, è stato dimostrato che le oscillazioni metaboliche sono di per sé sufficienti per allineare l’orologio circadiano nei tessuti periferici. Per sviluppare un modello che riproducesse in vitro condizioni sia fisiologiche che patologiche, raggiungendo un controllo spazio-temporale preciso del microambiente cellulare, le stimolazioni in frequenza sono state automatizzate in un dispositivo microfluidico progettato in modo dedicato per studi del ritmo circadiano. Infine, per estendere lo studio ai geni espressi con un pattern temporale circadiano, un nuovo metodo di analisi è stato proposto e caratterizzato. Il metodo permette di identificare geni circadiani da dati di trascrittomica, di suddividere i geni basandosi sulla fase della loro espressione, di visualizzare dati di trascrittomica nel loro complesso e di individuare rapidamente e in modo semplice modifiche a livello trascrizionale da una condizione biologica ad un’altra.
Gallagher, Michael William. "Coherent flow structures over mixed grain sized surfaces and their role in sediment transport". Thesis, University of Aberdeen, 1998. http://digitool.abdn.ac.uk/R?func=search-advanced-go&find_code1=WSN&request1=AAIU105984.
Pełny tekst źródłaDitas, Jeannine. "On the small-scale dynamics of cloud edges". Doctoral thesis, Universitätsbibliothek Leipzig, 2014. http://nbn-resolving.de/urn:nbn:de:bsz:15-qucosa-144262.
Pełny tekst źródłaVerney, John Parker. "Rhythmic perception and entrainment in 5-year-old children". Thesis, University of Cambridge, 2013. https://www.repository.cam.ac.uk/handle/1810/244940.
Pełny tekst źródłaMickett, John B. "Turbulent entrainment fluxes within the eastern Pacific warm pool /". Thesis, Connect to this title online; UW restricted, 2007. http://hdl.handle.net/1773/11005.
Pełny tekst źródłaBock, Elinor Rae. "Common Ground| A Look at Entrainment in Romantic Relationships". Thesis, The New School, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3566429.
Pełny tekst źródłaPast research has shown that entrainment facilitates social bonding in intimates and strangers. The current study investigated if synchronicity in romantic couples is disrupted by relationship discord. Rocking chair movements were used as an objective measure of synchronicity. Couples rocked together for 3 minutes to assess their baseline synchronicity, and again for 3 minutes after inducing a threat to the relationship in one member of each couple. It was hypothesized that satisfied couples would be more entrained than dissatisfied couples at baseline, as well as after inducing a relationship threat. Results indicated no significant difference in rocking between satisfied and dissatisfied couples at baseline. However, results supported that synchronicity was significantly disrupted in dissatisfied couples, but not satisfied couples, after the threat was induced. These results suggest that relationship satisfaction acts as a buffer to relationship threats and/or that satisfied couples are more likely to remain entrained even in the face of hardship.
Breda, Carlo. "Temperature and light entrainment of the Drosophila circadian clock". Thesis, University of Leicester, 2010. http://hdl.handle.net/2381/9743.
Pełny tekst źródłaPan, Jin. "Gas Entrainment in Two-Phase Gas-Liquid Slug Flow". Thesis, Imperial College London, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.516177.
Pełny tekst źródłaO'Connell, Aileen. "Observations of air entrainment and the limits of coatability". Thesis, Heriot-Watt University, 1989. http://hdl.handle.net/10399/915.
Pełny tekst źródłaBlenkinsopp, Christopher Edwin. "Air entrainment, splash and energy dissipation in breaking waves". Thesis, University of Southampton, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.435725.
Pełny tekst źródłaFung, Po Kan. "A fundamental study of air entrainment in steam condensers". Thesis, University of Cambridge, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.253839.
Pełny tekst źródłaIaccarino, Hannah Frances. "Gamma frequency entrainment attenuates amyloid load and modifies microglia". Thesis, Massachusetts Institute of Technology, 2017. http://hdl.handle.net/1721.1/109020.
Pełny tekst źródłaCataloged from PDF version of thesis. "January 2016."
Includes bibliographical references (pages 101-107).
Gamma oscillations (20-50 Hz), a common local field potential signature in many brain regions, are generated by a resonant circuit between fast-spiking (FS)-parvalbumin (PV)-interneurons and pyramidal cells. Changes in gamma oscillations have been observed in several neurological disorders. However, the relationship between gamma oscillations and cellular pathologies of these disorders is unclear. Here, we investigated this relationship using the 5XFAD mouse model of Alzheimer's disease (AD) and found reduced behaviorally driven gamma activity before the onset of plaque formation or evidence of cognitive decline. Because of the early onset of gamma deficits, we aimed to determine if exogenous gamma manipulations could influence disease pathology progression. We discovered that optogenetically driving FS-PV-interneurons at gamma frequency (40 Hz) reduced levels of amyloid-[beta] (A[beta])₁-₄₀ and A[beta] ₁-₄₂ isoforms in the hippocampus of 5XFAD mice. Neither driving FS-PV-interneurons at other frequencies, nor driving excitatory neurons, reduced A[beta] levels. Furthermore, driving FS-PV-interneurons at 40 Hz reduced enlarged endosomes and amyloid precursor protein (APP) cleavage intermediates in hippocampus. Gene expression profiling revealed an induction of microglia specific genes associated with morphological transformation of microglia and increased A[beta] phagocytosis by microglia. Inspired by these observations, we designed a non-invasive light-flickering paradigm that induced 40 Hz activity in visual cortex. The light-flickering paradigm profoundly reduced A[beta]₁-₄₀ and A[beta]₁-₄₂ levels in the visual cortex of pre-depositing mice and mitigated plaque load in aged, depositing mice. A GABAA antagonist completely blocked this effect; further evidence that GABAergic signaling is essential for this neuroprotective gamma activity. Finally, we showed that 40 Hz activity reduced tau phosphorylation in the TauP301S mouse model. Overall, our findings uncover a previously unappreciated function of the brain's gamma rhythms in neuroprotection by recruiting both neuronal and glial responses to mitigate AD-associated pathology.
by Hannah Frances Iaccarino.
Ph. D.
Lamarre, Eric. "An experimental study of air entrainment by breaking waves". Thesis, Massachusetts Institute of Technology, 1993. http://hdl.handle.net/1721.1/12685.
Pełny tekst źródłaWitz, Matthew J. "Mechanics of particle entrainment in turbulent open-channel flows". Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=225690.
Pełny tekst źródłaKallingal, George J. "The Role of Gastrin-releasing Peptide in Photic Entrainment". Kent State University / OhioLINK, 2008. http://rave.ohiolink.edu/etdc/view?acc_num=kent1208972062.
Pełny tekst źródłaKishore, Aravind. "Laminar Plunging Jets - Interfacial Rupture and Inception of Entrainment". University of Cincinnati / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1397476562.
Pełny tekst źródła