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Rozprawy doktorskie na temat „Endocrinology”

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Autor: Grafiati

Data publikacji: 4 czerwca 2021

Data aktualizacji: 3 września 2024

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1

Dodd, Will. "Pediatric Endocrinology". Digital Commons @ East Tennessee State University, 2020. https://dc.etsu.edu/etsu-works/8914.

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2

Berg, Erika L. "Endocrinology of equine metabolic pathophysiology". Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/4472.

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Thesis (Ph. D.) University of Missouri-Columbia, 2006.
The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on July 31, 2007) Includes bibliographical references.

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3

Campello, Raquel Saldanha. "Refeições ricas em carboidratos ou lipídeos diminuem a sensibilidade à insulina duas horas após o início da ingestão". Universidade de São Paulo, 2009. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-01072009-121431/.

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O efeito de refeições ricas em carboidratos e lipídeos sobre a sensibilidade à insulina foi avaliado. Além disso, investigou-se o conteúdo da proteína GLUT4 em músculo esquelético e tecido adiposo branco. Ratos foram realimentados por 1, 2, 4 e 6 horas com: refeição balanceada (B); rica em carboidrato (C) e rica em lipídeo (L). O índice glicose/insulina revelou que C e L apresentavam resistência à insulina 2 horas após o início da ingestão. No teste de tolerância à insulina, uma redução (~47%) na sensibilidade à insulina foi observada em C após 2 e 4 horas de realimentação. O teste de tolerância à glicose confirmou a resistência à insulina em C e L após 2 horas de ingestão. Não houve alteração no conteúdo de GLUT4, nos momentos em que se verificou alteração na sensibilidade à insulina. Tais resultados indicam que, em ratos, refeições não balanceadas (alto teor de carboidrato ou alto teor de lipídeo), induzem menor sensibilidade à insulina 2 horas após o início da ingestão, e este fenômeno não envolve alterações no conteúdo de GLUT4 nos tecidos avaliados.
The effect of high carbohydrate and fat meals on the insulin sensitivity was evaluated. Furthermore, it was investigated the content of GLUT4 protein on the skeletal muscle and white adipose tissue. Rats were refed for 1, 2, 4 and 6 hours with: balanced meal (B); high carbohydrate meal (C) and high fat meal (L). The glucose/insulin index shows that C and L meals exhibited insulin resistance after 2 hours of ingestion. In the insulin tolerance test, a reduction (~47%) in the insulin sensitivity was observed in C group after 2 and 4 hours of refeeding. The glucose tolerance test confirmed the insulin resistance in C and L-groups after 2 hours of ingestion and such phenomena did not involve alterations in the GLUT4 content on both skeletal muscle or white adipose tissue.

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4

Josif, Dina. "Cognitive assessment of certification examination in endocrinology". Thesis, McGill University, 1992. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=61300.

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The study focuses on the cognitive assessment of certification examination in medicine. The purpose was to investigate the relationship between the structure of the examination questions and the examinees' written responses. The responses from three groups of residents with undergraduate degrees from McGill (3), Toronto (2) and Manitoba (2) medical schools were used. A sample of one basic science and two clinical question in Endocrinology were selected. The responses were analyzed using cognitive methods which provided a qualitative assessment of subjects' knowledge structures relative to task.
The results showed that the responses did not always correspond to task requirements. There was a general tendency to focus on specific details that the subjects understood at the expense of the global aspect of the question. There was a greater variation in performance within groups than between groups. The results also suggest that undergraduate education may have less influence on the performance in certification examination than residency training. The importance of developing examination questions with high construct and criterion validity is discussed.

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5

Jenner, Lucy Jayne. "Endocrinology of early pregnancy in domestic ruminants". Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280376.

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6

Scott, Katy. "Behaviour and endocrinology of meerkats in zoos". Thesis, University of Exeter, 2014. http://hdl.handle.net/10871/16393.

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Zoo-based research is important both to inform management decisions on captive animals and because zoos, at their best, provide a naturalistic environment, which it is possible to manipulate, in which scientific research can be performed. Extending research to multiple zoos enables investigation into how variations between zoos impact their occupants. Comparing zoo animals to their wild conspecifics can inform management decisions, improve breeding and reintroduction programmes, educate the visiting public and allow assessment of the relevance of zoo-based research to the broader field. The impact of captivity on social animals is particularly interesting, as they cannot determine their own social environment. Meerkats (Suricata suricatta) are a highly social species of mongoose which have been extensively studied in the wild, and which are common in European zoos; they are therefore an ideal focal species with which to assess the impact of aspects of the zoo environment. This thesis presents a study of the behaviour, endocrinology and morphology of meerkats in ten zoos in the UK and one zoo in Germany. The size of captive meerkats' social groups was found to influence their behaviour and faecal glucocorticoid levels (fGCs), with animals in large groups exhibiting lower fGCs, which supports an optimum group size hypothesis. Meerkats in large groups also spent less time on sentry duty, although a sentry was posted more often in zoos than in the wild, reinforcing the model of state-dependent vigilance. Captive meerkats were found to weigh much more, on average, than their wild conspecifics, with 86.7% of adults more than two standard deviations heavier than the mean weight in the wild. Meerkats in larger enclosures were heavier than those in smaller ones; their weights also correlated with climate, with zoos in cool, dry locations having lighter meerkats. This research did not find that high levels of hormonal stress occur frequently in zoo meerkats, but obesity may pose a health threat to many individuals and its impacts should be a priority for veterinary research.

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7

Ninnes, Calum Edward. "Behavioural Endocrinology of Breeding Adelie Penguins (Pygoscelis adeliae)". The University of Waikato, 2008. http://hdl.handle.net/10289/2473.

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Measuring hormonal changes is vital for understanding how the social and physical environment influences behaviour, reproduction and survival. Various methods of hormone measurement exist, potentially explaining variation in results across studies; methods should be cross validated to ensure they correlate. I directly compare faecal and plasma hormone measurements (Chapter 2), and use the most suitable endocrine measure to test the Darling hypothesis (Chapter 3) - that breeding is hastened and synchronized in larger colonies due to increased social stimulation (mediated by the endocrine system). Blood and faecal samples were simultaneously collected from individual Adelie penguins (Pygoscelis adeliae) for comparison, and assayed for testosterone and corticosterone (or their metabolites). Sex differences and variability within each measure, and correlation of values across measures were compared. For both hormones, plasma samples showed greater variation than faecal samples. Males had higher corticosterone levels than females, but the difference was only significant in faecal samples. Plasma testosterone, but not faecal testosterone, was significantly higher in males than females. Correlation between sample types was poor overall, and weaker in females than in males; perhaps because measures from plasma represent hormones that are both free and bound to globulins, whereas measures from faeces represent only the free portion. Faecal samples also represent a cumulative measure of hormones over time, as opposed to a plasma 'snapshot' concentration. Faecal sampling appears more suitable for assessing baseline hormone levels. In the second study I examined, over two seasons, whether the timing of breeding varied with colony size; larger colonies present occupants with higher levels of social stimulation and are predicted to show earlier, more synchronous breeding. Baseline faecal hormone levels throughout the breeding season, and survival, were measured to investigate possible proximate and ultimate mechanisms for the results. The influence of environmental variability was examined, by relating the timing of breeding, survival, and endocrine changes to sea ice conditions. Colony size did not influence the timing or synchrony of breeding, survival, or hormone levels within years; perhaps because colonies in an Adelie rookery are not independent from the 'social environment' of adjacent colonies. Across years, synchrony in the smaller rookery was higher than in the larger rookery. The scale of these comparisons may exceed the applicability of the Darling hypothesis. Therefore, no support was found for the Darling hypothesis, at the colony or rookery level, in this species. Higher corticosterone metabolite and lower sex hormone levels in the first season correlated to later breeding and lower survival compared to the second season. This is likely due to the persistence of extensive sea ice conditions late into the first season. Researchers should take care in selecting the most appropriate method of hormone measurement for their question. Future studies testing the Darling hypothesis must carefully select their definition of a colony (i.e. a truly isolated social unit) and the scale at which the hypothesis is tested. Combining endocrine measurements with behavioural, survival, and environmental information allows for a more comprehensive interpretation of animal ecology.

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8

Ribadu, Yusufu. "Ultrasonography and endocrinology of ovarian cysts in cattle". Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.386799.

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9

Nobrega, Rafael Henrique. "Alterações do epitelio germinativo masculino, celulas endocrinas testiculares e celulas gonadotropicas durante o ciclo reprodutivo de Serrasalmus spilopleura (Kner, 1859) e Pimelodus maculatus (Lacepede, 1803)". [s.n.], 2006. http://repositorio.unicamp.br/jspui/handle/REPOSIP/317613.

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Orientadores: Irani Quagio-Grassiotto, Maria Ines Borella
Dissertação (mestrado) - Universidade Estadual de Campinas, Instituto de Biologia
Made available in DSpace on 2018-08-06T21:58:16Z (GMT). No. of bitstreams: 1 Nobrega_RafaelHenrique_M.pdf: 10312793 bytes, checksum: 13a65bc78504251ac2368131cd7f57fd (MD5) Previous issue date: 2006
Resumo: Nos peixes teleósteos, a unidade morfofuncional da espermatogênese é o espenrmatocisto ou cisto, constituído por células germinativas, em desenvolvimento sincrônico, envoltas perifericamente pelas células de Sertoli. Em função da cinética da espermatogênese e do tipo de reprodução (contínua ou sazonal), o epitélio germinativo pode se desenvolver de forma constante ou sofrer modificações cíclicas durante o ciclo reprodutivo. O presente trabalho teve como objetivo analisar, através de parâmetros histológicos, ultra-estruturais e imuno-histoquímicos, as alterações do epitélio germinativo em duas espécies de ciclos reprodutivos diferentes (Serrasalmus spilopleura - reprodução contínua e Pimelodus maculatus - reprodução sazonal) e correlacioná-las com as células esteroidogênicas e as células gonadotrópicas, no intuito de melhor compreender a fisiologia reprodutiva dos teleósteos tropicais de água doce. Em S. spilopleura, o epitélio germinativo organiza-se em cistos basais de espermatogônias e cistos apicais de células germinativas em desenvolvimento mais avançado. As espermatogônias basais apresentam intensa atividade proliferativa durante todo o ciclo reprodutivo. As células de Sertoli proliferam no intuito de acompanhar o crescimento dos cistos e aumentar o tamanho do testículo a cada ciclo reprodutivo. Quanto à esteroidogênese, a atividade 3"beta"-HSD é maior na região espermatogênica do que na região relacionada à espermiação. Em relação às células gonadotrópicas, as células LH são requeridas durante a espermatogênese e na espermiação, enquanto que as células FSH são mais ativas na liberação dos espermatozóides e provavelmente na proliferação das células sle Sertoli. Em P. maculatus, o epitélio germinativo passa por modificações morfofuncionais, categorizadas em quatro classes reprodutivas: regredida, maturação, maturação final e regressão. A proliferação das espermatogônias é intensa durante a maturação e depois diminui na maturação final e regressão. As células de Sertoli proliferam em maior freqüência na classe regredida, o que contribui para o crescimento do testículo durante o ciclo reprodutivo. A atividade 3"beta"-HSD é intensa na maturação e na maturação final, e depois diminui na regressão e na classe regredida. Os processos de espermatogênese e liberação de espermatozóides são dependentes de andrógenos. As células LH e FSH estão em maior quantidade durante a maturação e a maturação final, e depois diminuem na regressão e na classe regredida. A espermatogênese e a liberação dos espermatozóides são mais dependentes da atividade gonadotrópica do que os processos de proliferação espermatogonial e regressão testicular
Abstract: In teleost fish, the morphofuncional unit of the spermatogenesis is the spermatocyst or cyst, which are constituded by synchronous developmental germ cells surrounded by Sertoli cells. Depending on the spermatogenesis kinetics and the type of reproduction (continuous/non-seazonal or seazonal), the germinal epithelium may be constant or undego cyclical changes during the reproductive cyc1e. The aim, of the present work is to analyze, through histological, ultrastructural and immunohistochemical evaluation, the changes of the germinal epithelium in two different reproductive cycles (Serrasalmus spilopleura continuous/non-seazonal reproduction and Pimelodus maculatus - seazonal reproduction) and to correlate them with steroidogenic cells and gonadotropic cells, for a better knowledge on the reproductive physiology of the tropical fresh water teleosts. In S. spilopleura, the germinal epithelium was organized in basal cysts of spermatogonia and apical cysts of more advanced developmental germ cells. The basal spermatogonia had intense proliferative activity during the whole reproductive cycle. Sertoli cells proliferation occured in order to accompany the cyst growth and to increase the testis size during each reproductive cycle. For steroidogenic activity, 3"beta"-HSD was stronger in the spermatogenic area than in the area related to spermiation. In re1ation to gonadotropic cells, LH cells were requ~sted during spermatogenesis and spermiation, whereas FSH cells were more active in spermatozoa liberation and probably in the Sertoli celI proliferation. In P. maculatus, the germinal epithelium undergoes morphological changes, classified in 4 reproductive classes: regressed, maturation, final maturation and regression. The spermatogonial prolif~ration was intense during maturation and decreased in final maturation and regression. Sertoli cells proliferated more in regressed class, contributing to testis growth during the reproductive cycle. The 3"beta"-HSD activity was strong in maturation and final maturation, and decreased in regression and in regressed class. Then, spermatogenesis processes and spermatozoa release are dependent of androgenic. LH and FSH cells were in large number during maturation and final maturation, and decreased in regression and in regressed class. In P. maculatus, spermatogenesis and spermatozoa release are more dependent of the gonadotropic activity than the processes such as spermatogonial proliferation and testicular regression
Mestrado
Biologia Celular
Mestre em Biologia Celular e Estrutural

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10

Campello, Raquel Saldanha. "17b-estradiol aumenta a expressão de Slc2a4/GLUT4 em adipócitos 3T3-L1 via ESR1". Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/42/42137/tde-17042013-101853/.

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O GLUT4 (gene Slc2a4) é responsável pela captação de glicose sob estímulo insulínico, e alterações na sua expressão se relacionam à resistência à insulina (RI). Variações na concentração de estradiol (E2) estão relacionadas a RI e menor expressão deste transportador, mecanismo que pode ser mediado pelo fator transcricional NFk-B, um repressor de Slc2a4. Avaliou-se em células 3T3-L1 a regulação da expressão de Slc2a4/GLUT4, a atividade de ligação de NFk-B e a captação de glicose pelo E2 e o papel de ESR1 (isoforma 1 do receptor de E2) nesta regulação. Tratou-se as células por 1 dia com E2 e PPT (agonista de ESR1). O PPT aumentou a expressão de Slc2a4/GLUT4 na ausência ou presença de E2 bem como a captação de glicose e diminuiu a atividade de ligação de NFk-B. Os resultados apresentados demonstram que o E2, atuando via ESR1 aumenta a expressão de Slc2a4/GLUT4, efeitos estes parcialmente mediados por NFk-B, resultando em alteração na captação de glicose.
GLUT4 (gene Slc2a4) is responsible by insulin-induced glucose uptake and alterations in its expression are related to insulin resistance (IR). Variability in estradiol levels (E2) is related with IR and lower glucose transporter expression and this mechanism can be mediated by transcriptional factor NFk-B, which is an Slc2a4 repressor. Our aim was to evaluate in 3T3-L1 adipocytes the role of E2 in Slc2a4/GLUT4 expression, NFk-B binding activity and glucose uptake as well as the ESR1 (estrogen receptor 1) role in this regulation. For this, 3T3-L1 cells were treated for 1 day with E2 and PPT (ESR1-agonist). PPT enhanced Slc2a4/GLUT4 expression in the absence or presence of E2 as well as the glucose uptake and decreased NFk-B binding activity. Our results show that E2 increases Slc2a4/GLUT4 expression via ESR1 and this effect is partially mediated by NFk-B, and allow parallel changes in glucose uptake.

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11

Costas, Caudet Laura. "Reproductive factors, hormone use, and endocrine disruptors in the etiology of lymphoid neoplasms = Factors reproductius, ús d’hormones i disruptors endocrins en l’etiologia de les neoplàsies limfoides". Doctoral thesis, Universitat de Barcelona, 2017. http://hdl.handle.net/10803/565936.

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Lymphoid neoplasms are a heterogeneous group of cancers characterized by the neoplastic or clonal proliferation of lymphoid cells in different stages of differentiation. The incidence rate of these neoplasms has seen a rise in some western countries since the 1970s and it seems to have reached a plateau during the last decade. Incidence rates are higher in men than in women for most lymphoma subtypes; however, the causes explaining these differences by sex are unknown. We hypothetised that hormonal factors could have a role in lymphoma etiology. The general aim of this thesis was to assess the risk of lymphoid neoplasms in relation to reproductive factors and occupational exposure to endocrine disruptors. We used different studies and populations to evaluate our hypothesis: the EpiLymph study, the InterLymph consortium, the International Multiple Myeloma Consortium, and a systematic review. As well, we developed a new tool to estimate occupational exposures to a specific type of endocrine disruptors. We observed contradictory findings across studies and lymphoma subtypes concerning the association between lymphoma and parity, as well as hormonal contraceptives. We observed inverse associations between postmenopausal hormone therapy and lymphoma, although we noticed in our systematic review that cohort studies usually found null associations. We observed associations with lymphoma and prolonged (≥30 years) occupational exposure to endocrine disrupting chemicals, in particular for multiple myeloma and chronic lymphocytic leukemia. Associations were observed between lymphoma and prolonged occupational exposures to organic solvents, pesticides, brominated flame retardants, alkylphenolic compounds, and metals. To further explore the associations with alkylphenolic compounds, we developed a job-exposure matrix on these compounds considering relevant changes in use over time. In conclusion, our results indicate that reproductive factors and exogenous hormone use are unlikely to play a role in lymphomagenesis. The associations between occupational exposure to endocrine disrupting chemicals and lymphoma need to be further explored in studies using a more detailed exposure assessment.

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12

Sarkar, Pampa. "Amniotic fluid endocrinology and its association with maternal stress". Thesis, Imperial College London, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.486366.

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The ability of the early intrauterine environment to program fetal neurodevelopment has been documented in several species, and there is evidence to suggest that a similar process may occur in humans. Glucocorticoids are the primary candidates for fetal hypothalamic-pituitary-adrenal (HPA) programming, but testosterone and DHEAS may also be involved. This thesis examines the relationship between these amniotic fluid honnones, particularly in the context of prenatal stress. Human studies lack the precision of animal experimental paradigms, and most stress protocols in humans have involved laboratory stressors poorly standardised for duration and nature of exposure. I aimed to use a standardised clinical stressor to examine the endocrine response in maternal plasma and amniotic fluid. I hypothesised that amniocentesis in a clinical setting elicits a maternal stress response associated with alterations in amniotic fluid steroidal hormones. I found amniocentesis to be associated with raised Spielberger state anxiety scores, validating the use of this procedure as a clinical model of psychological stress. Despite high state scores, only a modest rise of maternal cortisol (variance of 4%) was noted suggesting the response of an attenuated maternal HPA axis. I observed a positive correlation between maternal plasma cortisol and amniotic fluid cortisol that increased with gestational age. The magnitude of the correlation between maternal and amniotic fluid cortisol increased markedly with maternal state anxiety. A significant, positive correlation was observed between amniotic fluid cortisol and amniotic fluid testosterone. Amniotic fluid DHEAS correlated negatively with state anxiety scores but positively with maternal cortisol. This thesis characterises the relationships between the steroidal hormones cortisol, testosterone and DHEAS in amniotic fluid and in maternal plasma, especially in the context of prenatal stress generated by imminence of amniocentesis. The observations of a positive correlation between maternal and amniotic fluid cortisols, the magnitude increasing with gestation and maternal state anxiety scores, together with positive correlations between amniotic fluid cortisol and testosterone suggest more then one mechanism by which prenatal stress may influence fetal development.

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13

Wobber, Victoria Elizabeth. "Comparative Cognitive Development and Endocrinology in Pan and Homo". Thesis, Harvard University, 2012. http://dissertations.umi.com/gsas.harvard:10253.

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Key insights into the evolutionary origins of human social behavior can be gained via study of our closest living relatives, bonobos (Pan paniscus) and chimpanzees (Pan troglodytes). Despite being equally related to humans, these two species differ importantly in aspects of their morphology, physiology, behavior, and cognition. Morphological comparisons reveal numerous traits in bonobos that can be viewed as paedomorphic, or juvenile, relative to chimpanzees. Meanwhile, comparisons of endocrinology in the two species suggest that aspects of steroid physiology have changed significantly in bonobos in line with their reductions in male mating competition. Based on this evidence, I tested the hypothesis that behavioral and cognitive differences between bonobos and chimpanzees derive from changes in their 1) developmental trajectories of behavioral and cognitive traits and 2) neuroendocrine influences on behavior and cognition. I tested this hypothesis by studying semi free-ranging populations of bonobos and chimpanzees. First, I found that bonobos retained juvenile levels of food sharing and social inhibition into adulthood, leading them to differ from chimpanzees in these traits as adults. Second, I found that bonobos showed muted elevations in their levels of testosterone from infancy to adulthood in comparison to chimpanzees, suggesting that numerous aspects of development differ between these two species. Third, I found that male bonobos and chimpanzees differ in their immediate neuroendocrine shifts surrounding competition, implicating changes in proximate mechanisms influencing social behavior between the two species. Fourth, I found that patterns of cognitive development in these two apes differed significantly from those of human children. These results provide substantial support for my hypothesis that phenotypic differences between bonobos and chimpanzees evolved via shifts in bonobo development and neuroendocrine physiology. More broadly, they illustrate how behavioral and cognitive evolution can occur through changes in ontogenetic trajectories and neuroendocrine mechanisms. These findings thus show the merits of integrating ultimate and proximate levels of analysis in studies of the evolution of human behavior and cognition.
Human Evolutionary Biology

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McLaughlin, Casey Lee. "Mercury Exposure And Chronic Food Stress Elevate Corticosterone In Blood But Not Feathers". W&M ScholarWorks, 2020. https://scholarworks.wm.edu/etd/1616444459.

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Bird abundance in North America has declined by almost 30% in just the past 50 years. It is crucial that we understand the many factors contributing to declines, including the impacts of environmental contaminants. Mercury is a persistent and global neurotoxic contaminant of aquatic systems that will continue to increase in the environment as anthropogenic activities and climate change accelerate its emission. The impact of mercury on songbirds, a large and diverse but declining taxon, is not well understood. I sought to better understand the effects of mercury exposure on songbirds by studying its impact on the environmentally sensitive hypothalamic-pituitary-adrenal axis, which controls the stress response mediated by the hormone corticosterone. Using adult, captive-bred zebra finches as a model songbird, I tested the effect of an environmentally relevant level of dietary mercury on corticosterone in both blood and feathers. I also tested the effect of an additional stressor – chronic, unpredictable food deprivation – both on its own and in combination with mercury exposure, to better estimate how mercury might impact birds differently when another challenge occurred simultaneously. Baseline corticosterone was measured in the blood. Corticosterone was also measured from primary feathers grown during the treatment period, and mercury was measured in those same feathers, to test whether this minimally invasive technique might be useful in assessing stress due to mercury exposure in the field. The resultant baseline blood corticosterone levels were best explained by models including treatment, time elapsed between disturbance and sampling, sex, and an individual’s change in body mass over the study period. On average, birds under mercury stress alone or in combination with food stress had higher baseline blood corticosterone levels than controls. Interestingly, birds in the dual stress group did not exhibit the expected gradual increase in blood corticosterone levels in the first three minutes after disturbance. This was the opposite of all other groups, in which birds sampled longer after the initial disturbance of researchers entering the room had higher corticosterone levels. Feather corticosterone was not correlated with blood corticosterone. While treatment group alone was not related to feather corticosterone, the interaction between treatment group and pre-treatment feather corticosterone predicted corticosterone in replacement feathers. In individuals that were not exposed to mercury, there was a positive correlation between original and replacement feather corticosterone. However, mercury exposure disrupted this association. Chronic mercury exposure appears to elevate baseline corticosterone levels in adult songbirds, which could be detrimental to their health. Faced with combined mercury and food stressors, the stress response may have been suppressed, as suggested by the lack of an increase in corticosterone with time since disturbance. An effect of mercury on feather corticosterone was only observed when considering both treatment group and feather corticosterone before mercury exposure, so caution should be exercised in using feather corticosterone as a bioassay for contaminant or food stress in the field. Further study of stress-induced corticosterone is necessary to better understand the effects seen here, and the modulating roles of feather color and size, also examined here, must be considered.

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15

Nicoll, James B. "TR Phosphorylation & Nuclear Import". W&M ScholarWorks, 2001. https://scholarworks.wm.edu/etd/1539626303.

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Grespin, Matthew Edward. "Nuclear Export of the Thyroid Hormone Receptor [Alpha]". W&M ScholarWorks, 2008. https://scholarworks.wm.edu/etd/1539626868.

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Subramanian, Kelly Sue. "Nuclear Export Dynamics of Thyroid Hormone Receptors". W&M ScholarWorks, 2012. https://scholarworks.wm.edu/etd/1539626924.

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18

Walker, Susan Lorene. "Aspects of reproductive endocrinology in the red wolf (Canis rufus)". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 2000. http://www.collectionscanada.ca/obj/s4/f2/dsk1/tape2/PQDD_0032/MQ47373.pdf.

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19

Ritchie, Andrew John. "Endocrinology, oncogene expression and outcome in carcinoma of the lung". Thesis, Queen's University Belfast, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357457.

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20

Hector, J. A. L. "The comparative reproductive endocrinology of Diomedea Albatrosses at South Georgia". Thesis, University of Bristol, 1985. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.354456.

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21

Richard, David Seward. "Endocrinology of photoperiodic diapause induction in two species of Diptera". Thesis, University of Edinburgh, 1987. http://hdl.handle.net/1842/11893.

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Ruang-Rit, Krissana. "Endocrinology of flexible development in the flour beetle, Tribolium freemani". Diss., Kansas State University, 2016. http://hdl.handle.net/2097/32547.

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Doctor of Philosophy
Entomology
David C. Margolies
Yoonseong Park
Insect metamorphosis is driven by two major hormones, juvenile hormone (JH) and ecdysone (Ec). The presence of JH with an Ec peak in each stadium results in larval-larval molting whereas in the last larval instar a decline of JH to undetectable level combined with pulses of Ec leads to larval-pupal metamorphosis. Larval-pupal metamorphosis normally occurs after a certain number of larval instar and upon reaching a certain size (critical weight). However, in the flour beetle, Tribolium freemani, under crowded conditions larva continue larval-larval molting (LLC) without pupation for longer than 14 instars (6 months). Previous studies have implicated high JH titer as preventing the metamorphosis leading to supernumerary molts. My investigation of JH roles in LLC started by asking whether suppression of JH would rescue the LLC phenotype and allow pupal metamorphosis. Using RNA interference (RNAi), I found that under crowded conditions RNAi of T. freemani methyltransferase3 (TfMT3), which encodes a crucial enzyme for the final methylation step in the JH biosynthesis, or RNAi of T. freemani Krüppel homolog1 (TfKr-h1), the JH downstream gene, did not rescue the larvae but resulted in prepupal lethality. Surprisingly, under crowded conditions prepupal lethality was rescued by RNAi of both TfMT3 and TfKr-h1 administered together, although developmental arrest occurred at the pharate adult stage; this is also the phenotype of TfKr-h1 RNAi-treated larvae under isolated conditions. In investigations of the role of Ec titer in LLC, lethality of the larvae with RNAi of TfMT3 under crowded conditions was associated with the loss of the major ecdysteroid peak, while TfKr-h1 RNAi-treated larvae under crowded conditions showed a delayed, but normal, Ec peak occurring at prepupal arrest. The pattern of Ec peak in RNAi of both TfMT3 and TfKr-h1 together was similar to that with TfKr-h1 RNAi alone. I suggest that a hormonal imbalance, high JH and high Ec in the prepupal arrest of TfKr-h1 RNAi, was rescued by RNAi of both TfMT3 and TfKr-h1 for low JH and high Ec. These results demonstrate that the signaling pathways for LLC are through at least two independent pathways; JH biosynthesis and TfKr-h1-mediated JH response.

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23

Kersey, David C. "Reproductive and adrenal endocrinology of the giant panda (Ailuropoda melanoleuca)". Fairfax, VA : George Mason University, 2008. http://hdl.handle.net/1920/3428.

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Thesis (Ph.D.)--George Mason University, 2008.
Vita: p. 180. Thesis director: Thomas C. Wood. Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Environmental Science and Public Policy. Title from PDF t.p. (viewed Mar. 17, 2009). Includes bibliographical references (p. 156-179). Also issued in print.

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24

Walker, Susan Lorene. "Aspects of reproductive endocrinology in the red wolf (Canis rufus)". Connect to this title online, 1999. http://www.nlc-bnc.ca/obj/s4/f2/dsk1/tape2/PQDD%5F0032/MQ47373.pdf.

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25

Bastos, Alexandre Fernandes Lima. "Avaliação endocrinológica da reprodução de muriquis do sul em cativeiro (Brachyteles arachnoides - E. GEOFFROY, 1806) por meio de dosagem de metabólitos de esteróides fecais". Universidade de São Paulo, 2006. http://www.teses.usp.br/teses/disponiveis/10/10131/tde-23042007-143151/.

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A endocrinologia reprodutiva do muriqui do sul B. arachnoides foi avaliada em quatro fêmeas adultas pela dosagem de metabólitos fecais de estrógenos e em quatro machos adultos e um macho subadulto pela dosagem de metabólitos de testosterona e glicocorticóides durante um período de onze meses em duas diferentes condições restritivas, ilha de 600m2, Curitiba (PPC) e viveiro (15,40x5,85x4,70m) Rio de Janeiro (CPRJ). As fêmeas apresentaram grande variação individual nas concentrações de estrógenos e progestinas fecais ao longo do período de estudo, três não apresentaram atividade ovariana no período de outubro-dezembro e apenas uma apresentou atividade durante todos os períodos amostrados. Mesmo com níveis baixos de esteróides as fêmeas apresentaram comportamento perceptivo e cópulas. Os machos do PPC apresentaram níveis significativamente mais altos de glicocorticóides e níveis significativamente mais baixos de testosterona do que os machos do CPRJ (p<0,05) apresentaram. O macho subadulto apresentou níveis significativamente mais baixos para metabólitos de testosterona. Nos machos as cópulas ocorreram próximo às elevações das concentrações de testosterona. Em três situações grandes elevações dos níveis de glicocorticóides fecais puderam ser relacionadas a situações estressantes. Nosso estudo comprovou a eficácia do método empregado para monitoramento reprodutivo bem como para avaliar situações estressantes.
The reproductive endocrinology of the southern muriqui (Brachyteles. Arachnoids) was evaluated through the dosage of fecal metabolites steroids for 04 adult females and fecal metabolites of testosterone and glucocorticoids for 04 adult males and 01 subadult male. The study was conducted over an eleven month period at two environmental conditions: a) an island of 600 m2, with natural vegetation, at Curitiba Zoo (PPC) and b) a large cage of 15,40X5,85X4,70m at Rio de Janeiro Primatological Centre (CPRJ). It was observed that females had large strogen interindividual variation and fecal progestins: three females did not show ovarian activity over a partial period of the study, while ovarian activity was observed for all sample periods for one female. Despite the detection of low levels of steroids, proceptive behaviour and copulations were observed. The PPC males showed significant levels of glicorticoids and testosteorne when compared to the CPRJ males (p<0.05). The subadult male exhibited the lowest level of testosterone metabolites and those differences were significant when compared to the adult males (p<0.05). For all males, copulations occurred when testosterone levels were highest and peaks of glucorticoids were linked to stressfull situations. This study have shown that the method used was effective for reproductive monitoring as well as for evaluating stressfull situations.

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Coutinho, Ana Rafaela Draque. "Estudo retrospetivo das principais alterações comportamentais e a sua relação com a concentração sérica basal de T4 total em gatos com hipertiroidismo". Master's thesis, Universidade de Évora, 2019. http://hdl.handle.net/10174/25437.

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O hipertiroidismo é a endocrinopatia mais prevalente em gatos com idade superior a oito anos. A prevalência da mesma tem vindo a aumentar ao longo dos últimos anos devido, maioritariamente, a uma maior consciencialização dos tutores e dos médicos veterinários quanto à doença, sabendo reconhecer inclusive as alterações comportamentais características. A presente dissertação tem como objetivo identificar as principais alterações comportamentais de gatos hipertiroideus, reportadas pelos respetivos tutores. Tal foi concretizado com um inquérito feito a todos os tutores dos gatos através de contacto telefónico. Adicionalmente, pretendeu-se relacionar determinadas alterações comportamentais de gatos hipertiroideus com o nível de concentração sérica de T4 total. Conclui-se que as principais alterações comportamentais reportadas em gatos hipertiroideus foram a vocalização excessiva (30%), a ansiedade generalizada (26,7%) e a hiperatividade (26,7%). Os resultados sugerem também uma associação significativa entre conjuntos de alterações comportamentais e a concentração de T4 total em gatos hipertiroideus; ABSTRACT: Retrospective study of the main behavioural problems and its relationship with basal total serum T4 concentration in hyperthyroid cats Hyperthyroidism is the most prevalent endocrinopathy in cats older than eight years old, and this prevalence has been increasing over the years, mainly because of the increased awareness by owners and veterinarians, including how to recognize characteristic behavioural problems. The present study’s major objective is to survey the main behavioural issues in hyperthyroid cats, as reported by their respective owners. The same inquiry form was made to all the cats’ owners through telephonic contact. Additionaly, it was intended to prove a relationship between certain behavioural problems in hyperthyroid cats and basal total serum T4 concentration. In conclusion, the main reported behavioural problems in hyperthyroid cats were excessive vocalization (30%), general anxiety (26,7%) and hyperactivity (26,7%). The results suggest as well that there’s an apparent correlation between basal total serum T4 concentration and sets of behavioural problems in hyperthyroid cats.

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Silva, Ana Carolina Brasil Costa. "Clínica de animais de companhia: hipertiroidismo felino". Master's thesis, Universidade de Évora, 2019. http://hdl.handle.net/10174/26210.

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O presente relatório vem no seguimento do estágio curricular feito no Hospital VetSet, para conclusão do Mestrado Integrado em Medicina Veterinária. Este relatório incluirá três componentes: descrição da casuística acompanhada; monografia sobre o tema do hipertiroidismo felino; e relato de dois casos clínicos sobre o mesmo tema. Durante o estágio foram acompanhadas as áreas de medicina preventiva, clínica médica e cirúrgica, sendo a espécie canina a mais consultada. As subáreas da vacinação, gastroenterologia e glândulas anexas, e cirurgia de tecidos moles, foram, respetivamente, as mais observadas. Quanto à monografia: o Hipertiroidismo é a doença endócrina mais comummente diagnosticada entre a população felina, em especial na fase sénior. Com um quadro clínico variável e uma série de fatores apontados como predisponentes, esta entidade clínica pode ser diagnosticada através do doseamento sérico das hormonas tiroideias. O seu prognóstico é geralmente favorável, existindo na atualidade várias modalidades terapêuticas disponíveis; Abstract: Clinic and surgery of small animal – Feline Hyperthyroidism This report follows the curricular traineeship done at the VetSet Hospital, for the conclusion of the master’s degree in veterinary medicine. This report will include three components: description of the followed casuistry; A monograph about feline hyperthyroidism; and a report of two clinical cases on the same topic. During the internship, the areas of preventive medicine, medical and surgical clinic, were observed, being the canine species the most consulted. The sub-areas of vaccination, gastroenterology and attached glands, and soft tissue surgery, respectively, were the most represented. Hyperthyroidism is the most commonly diagnosed endocrine disease among the feline population, especially in the senior phase. With a variable clinical presentation and a large number of factors identified as the predisposing ones, this disease can be diagnosed by serum thyroid hormone measurement. Its prognosis is generally favorable, and there are currently several available therapeutic modalities.

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Mendes, Beatriz Correia Carvalho Azinhais. "Clínica e cirurgia de pequenos animais". Master's thesis, Universidade de Évora, 2019. http://hdl.handle.net/10174/26214.

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O presente relatório foi elaborado no âmbito do mestrado integrado em Medicina Veterinária e encontra-se dividido em duas partes. A primeira parte tem como objetivo descrever a casuística observada durante o estágio curricular decorrido no período de 2 de janeiro de 2019 a 30 de abril de 2019, no Hospital Veterinário Muralha de Évora. Na segunda parte é feita uma revisão bibliográfica sobre o hipoadrenocorticismo em cães, seguida pela descrição de um caso clínico acompanhado durante o estágio. O hipoadrenocorticismo é uma doença pouco comum, tanto em cães como em gatos. O grande desafio de diagnóstico assenta no facto da sua apresentação clínica ser semelhante a diversas outras doenças, sendo assim apelidado de “o grande imitador”; Abstract: Small animal medicine and surgery The current report was carried out for the completion of the Master’s Degree in Veterinary Medicine and it is divided in two parts. The first part aims to describe the clinical cases observed during the internship that took place from January the 2nd, 2019 to April 30th of 2019, at the Muralha de Évora Veterinary Hospital. The second part is constituted by a bibliographical review of hypoadrenocorticism in dogs, including a description of a clinical case followed during the internship. Hypoadrenocorticism is an uncommon disease, both in dogs and cats. The major diagnostic challenge lies in the fact that its clinical presentation is similar to many other diseases, hence the nickname “the great pretender”.

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29

Falcão, Diana Rita. "Clínica e cirurgia de animais de companhia". Master's thesis, Universidade de Évora, 2017. http://hdl.handle.net/10174/21308.

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O presente relatório foi realizado no âmbito do mestrado integrado em Medicina Veterinária e está dividido em duas partes. A primeira parte é constituída por uma descrição da casuística observada durante o estágio curricular de seis meses realizado no Hospital Veterinário das Laranjeiras. Da segunda parte fazem parte uma revisão bibliográfica acerca da resolução cirúrgica de neoplasias das glândulas adrenais caninas e a discussão de um caso clínico seguido durante o estágio no relativo ao mesmo tema. As neoplasias das glândulas adrenais podem ter origem cortical ou medular, produzindo substâncias distintas que resultam na manifestação de sinais clínicos também eles distintos. O diagnóstico definitivo só é possível mediante histopatologia, mas o estabelecimento de um diagnóstico presuntivo através da história clínica, exame físico, exames laboratoriais e exames complementares é essencial para decidir qual o maneio peri-operatório adequado. O tratamento de eleição para estes pacientes é a remoção da glândula adrenal afetada; ABSTRACT: Small animal veterinary surgery and clinics The current report was carried out for the completion of the Master degree in Veterinary Medicine and is divided in two parts. The first part is formed by a description of the cases followed during the six months’ traineeship completed in “Laranjeiras” Veterinary Hospital. The second part is composed by a bibliographic review about the surgical resolution of canine adrenal neoplasms and a report of a case seen during the traineeship, concerning the same subject. The adrenal glands neoplasms can arise from the adrenal cortex or from the adrenal medulla, producing distinct substances that also result in distinct clinical signs. The definitive diagnosis can only be made with histopathology, but the establishment of a presumptive diagnosis is essential to decide the correct peri-operative approach. The treatment of choice for these patients is the affected adrenal gland removal.

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Othen, Leanne Stacey. "Reproductive endocrinology of wood bison during estrus synchronization, superovulation and pregnancy". Thesis, National Library of Canada = Bibliothèque nationale du Canada, 1997. http://www.collectionscanada.ca/obj/s4/f2/dsk2/ftp04/mq24494.pdf.

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31

Dodson, S. E. "Reproductive endocrinology of the heifer from birth to the peripubertal period". Thesis, University of Nottingham, 1986. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.376401.

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32

Ianculescu, Alexandra G. "Investigations of 3-iodothyronamine as a novel regulator of thyroid endocrinology". Diss., Search in ProQuest Dissertations & Theses. UC Only, 2009. http://gateway.proquest.com/openurl?url_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:dissertation&res_dat=xri:pqdiss&rft_dat=xri:pqdiss:3352462.

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Thesis (Ph.D.)--University of California, San Francisco, 2009.
Source: Dissertation Abstracts International, Volume: 70-04, Section: B, page: 2072. Advisers: Thomas S. Scanlan; Kathleen M. Giacomini.

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33

Buffin, Nicholas James. "Loss of Post-natal Growth Hormone Receptor Signaling in Skeletal Muscle of Mice Does Not Affect Muscle Fiber Size and Response to Pathological Injury". Thesis, Icahn School of Medicine at Mount Sinai, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=1537185.

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In my thesis I investigated whether loss of growth hormone receptor (GHR) signaling affects post-natal skeletal muscle development and regenerative ability in adult male mice, and whether the effect is via insulin-like growth factor-1 receptor (IGF-1R) signaling. Mouse models were used that had a post-natal muscle-specific loss of GHR signaling (mGHRKO), insulin-like growth factor receptor/ insulin receptor (IGF-1R/IR) signaling (MKR ), and loss of both GHR and IGF-1R/IR signaling (mGHRKO/MKR). The loss of GHR signaling did not alter muscle igf-1 expression, fiber cross sectional area, fiber type proportions, or regenerative fusion ability. Further more, loss of IGF-1R/IR signaling decreased regenerative ability. In conclusion, my data suggests that GHR signaling does not play a role in post-natal skeletal muscle development or regenerative fusion ability, and that IGF-1R/IR signaling has an effect that is independent of direct GH effects on muscle, though may be affected by systemic GH/IGF-1 function.

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34

Ward, Stuart David Charles. "The role of residues Tyr381 to Val387, in transmembrane domain six of the rat M1 muscarinic acetylcholine receptor, in agonist binding and receptor activation". Thesis, University College London (University of London), 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.390625.

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35

Herbert, Linda Catherine. "An investigation into the effects of maternal thyroid disorders on the development of the rat embryo from 9.5 to 11.5 days". Thesis, University of Liverpool, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.333627.

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Hazlerigg, David G. "Cellular actions of melatonin". Thesis, University of Cambridge, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.295370.

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Michailidou, Zoi. "Modelling altered glucocorticoid sensitivity : from HPA axis to metabolic abnormalities in mice and humans". Thesis, University of Edinburgh, 2008. http://hdl.handle.net/1842/2689.

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The primary determinants of tissue glucocorticoid action are glucocorticoid receptor (GR) density and intracellular levels of ligand, the latter determined both by activity of the hypothalamic-pituitary-adrenal (HPA) axis and cellular activity of 11beta- hydroxysteroid dehydrogenase (11beta-HSD) enzymes that interconvert active 11- hydroxy (corticosterone, cortisol) and inactive 11-keto (11-dehydrocorticosterone, cortisone) glucocorticoids. Here, the contribution of GR density and ligand levels in determining body composition and metabolic phenotype have been investigated in mice and in humans. Genetic evidence in humans implicates variations in the GR gene in the regulation of the HPA axis as well as the control of body fat distribution, metabolic parameters and blood pressure. Although GR deficient mouse models have been previously generated (with homozygous nulls dying at birth), the effects of altered GR density upon fat distribution and blood pressure have not been described. This study addresses the relationship between GR density and metabolic parameters, including body fat distribution, insulin resistance and hypertension. A novel line of mice harbouring a null mutation in the GR gene (GR+/-) was generated from an ES cell line in which a beta-galactosidase-neomycin phosphotransferase (beta geo) reporter cassette was fused with GR. The resulting fusion protein lacks part of the DNA binding domain and the entire ligand binding domain and is transcriptionally inactive. In addition, the beta-galactosidase enzyme activity “reports” activity of the GR gene promoter. GR-/- mice are present in a normal Mendelian ratio before birth. Intriguingly, 1 (of 36/146 expected if null allele not lethal) survived to adulthood suggesting this might be a hypomorphic rather than a null allele. Heterozygous 15 (GR+/-) mice showed 40-45% reductions in GR mRNA levels in the hippocampus, paraventricular nucleus of the hypothalamus, pituitary gland and adipose tissue, 30% in liver, 56% in muscle and 67% in adrenals. X-gal staining of GR+/- brain sections showed that GR-beta gal is present throughout, mirroring GR mRNA expression. Adult GR+/- mice had larger adrenals, higher evening plasma corticosterone levels and greater corticosterone responses following 10 minute restraint suggesting a hyperactive HPA axis. Compared to GR+/+ littermates, GR+/- mice had similar body weight gain on normal chow or high fat diet, with unaltered fat depot (inguinal, epididymal, mesenteric) weights and similar glucose and insulin tolerance. However, GR+/ - mice had higher (10%) systolic blood pressure, associated with activation of the renin-angiotensin system. Thus GR haploinsufficiency in mice causes increased blood pressure and accords with data associating GR polymorphisms with hypertension in humans. The role of altered GC sensitivity was also investigated in a mouse model of HPA axis hypoactivity pro-opiomelanocortin null (POMC) mice. POMC-null mice are obese due to central melanocortin deficiency. In contrast to most rodent models of obesity, POMC-null mice are also glucocorticoid deficient due to ACTH deficiency. Previous data have shown that glucocorticoid replacement in POMC-null mice exaggerated hyperphagia, obesity and insulin resistance and caused hypertension. Here, the contribution of peripheral glucocorticoid sensitivity was investigated. POMC-null mice have increased liver and retroperitoneal fat GR mRNA levels but, specifically in adipose tissue, decreased levels of mRNA encoding 11beta-HSD1, a reductase which regenerates active glucocorticoids, thus amplifying their action.

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38

Long, Nathan P. "Tamoxifen and ICI 182,780 activate GPER-1 in orphanin FQ neurons to facilitate sexual receptivity in female rats". Thesis, California State University, Long Beach, 2016. http://pqdtopen.proquest.com/#viewpdf?dispub=10142967.

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Infusion of 17β-estradiol into the arcuate nucleus of the hypothalamus (ARH) 47.5 hours after estrogen benzoate (EB) priming rapidly facilitates sexual receptivity (lordosis) via G protein-coupled estrogen receptor 1 (GPER) that deactivates µ-opioid receptors (MOP) in the medial pre-optic nucleus of the hypothalamus (MPN). Initial estradiol inhibits lordosis via activating an ARH neurocircuit that activates MPN MOP, and simultaneously upregulates orphanin FQ/ nociception (OFQ/N), its cognate receptor (ORL-1), and progesterone receptor (PR) in the ARH. Subsequent ORL-1 activation 48 hours post-EB deactivates MPN MOP to facilitate lordosis. Thus, I hypothesized that GPER directly regulates OFQ/N neurons and tested whether EB increased coexpression of GPER and OFQ/N in ARH neurons. EB significantly increased the number of GPER OFQ/N expressing neurons. Antiestrogens, tamoxifen (TAM) and ICI 182,780 (ICI), are treatments for some estrogen responsive tumors, but sometimes exacerbate tumor proliferation via GPER. I hypothesized that TAM and ICI activate ARH GPER and facilitate lordosis via deactivation of MPN MOP. In EB-primed rats, ARH infusion of either TAM or ICI facilitated lordosis and deactivated MPN MOP. GPER antagonist, G15, blocked these results. Thus, TAM and ICI rapidly activate ARH GPER neurons that express OFQ/N to facilitate sexual receptivity.

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39

Laczko, Stephen M. "Evaluation of the Thyroid Endocrine System in Two Flatfish Species in Relation to Exposures to Legacy Contaminants and Contaminants of Emerging Concern". Thesis, California State University, Long Beach, 2018. http://pqdtopen.proquest.com/#viewpdf?dispub=10826608.

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Anthropogenic contaminants have been well documented in Southern California coastal marine waters and are largely associated with point source pollution entities like waste water treatment plants (WWTPs). This study measured known and suspected contaminants capable of disrupting physiological and endocrine functions in marine organisms. Thyroid endocrine and hepatic contaminant concentrations were measured in English Sole (Parophrys vetulus) and Hornyhead Turbot (Pleuronichthys verticalis) residing at a WWTP outfall location and two other locations, up- and down-current from the outfall. Fish from the outfall and down current locations had higher levels of contaminant compounds and altered thyroid endocrine physiology compared to the up-current reference location. Selected contaminants were significantly correlated with thyroid endocrine parameters, consistent with observed differences in contaminant levels among sites.

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Carrihill, Michelle Margaret. "An audit of the thyroid screening programme in the Peninsula Maternal and Neonatal Services". Master's thesis, University of Cape Town, 2008. http://hdl.handle.net/11427/2782.

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Includes abstract.
Includes bibliographical references (leaves 56-60).
To audit the crod blood thryoid screening programme in the Peninsula Maternal and Neonatal Services (PMNS) in the 5 year period from 01/01/2000 to 31/12/2004, focusing on coverage, recall rate and success, number of cases detected, incidence of congenital hypothryoidism in this population; and cost efficiency of the programme. All babies born in the PMNS from 01/01/2000 to 31/12/2004 were included in the audit. The medical records of all babies recalled following an abnormal screen were examined. 140 507 babies were born in the PMNS during the audit period, while 130 389 primary Thyroid Stimulating Hormone (TSH) screens were done (92.8% coverage). 2 207 of the screened babies had abnormal results requiring review.

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41

Walton, James C. "Photoperiod, Brain Plasticity, and Behavior". The Ohio State University, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=osu1364994837.

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Qiu, Xiaoliang. "Kiss1 Neurons and Metabolic Sensing". University of Toledo Health Science Campus / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=mco1373034912.

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43

Lemelin, Sarah Ross. "The Effects of Methylmercury on Corticosterone and Thyroid Hormones in a Breeding Songbird Model Organism". W&M ScholarWorks, 2011. https://scholarworks.wm.edu/etd/1539626909.

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Sylvester, Christopher John. "A Demonstration of Photoresponsiveness in Laboratory Rats using Whole Animal and Neuroendocrine Approaches". W&M ScholarWorks, 1997. https://scholarworks.wm.edu/etd/1539626097.

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Martins, Dinorah Fernandes Gioia. "Obesidade: Estudo das Representações Sociais de Endocrinologistas em Hospital Público". Universidade de São Paulo, 1998. http://www.teses.usp.br/teses/disponiveis/47/47133/tde-30112012-113617/.

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O presente trabalho teve como objetivo estudar a psicodinâmica das Representações Sociais (RS) de endocrinologistas de hospital público sobre obesidade, identificando-as e buscando detectar seu inconsciente relativo, ou seja, a lógica emocional segundo a qual se estruturam. Foram realizadas 10 (dez) entrevistas com médicos endocrinologistas de rede pública, (05 do sexo feminino e 05 do sexo masculino) com idade variável de 28 a 44 anos de idade. O tempo de especialização variou de dois a dezoito anos. As entrevistas foram semi-estruturadas, no sentido de haver uma pré-estrutura mínima, permitindo ao entrevistado espontaneidade e fluência de expressão. Usou-se técnicas encobertas, com perguntas gerais e abrangentes. Desejou-se que o tema - obesidade - surgisse espontaneamente. O tratamento dos dados foi de acordo com o referencial psicodinâmico, numa abordagem qualitativa. Conclui-se que o médico é o intérprete das ideologias socialmente circulantes a respeito da obesidade. Suas condutas são pautadas pelas características de personalidade, pelas informações científicas, e pela influência midiática
Not informed by the author

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46

Ríos, Alcolea Martín. "Métricas entre modelos lineales y su aplicación al tratamiento de datos en medicina". Doctoral thesis, Universitat de Barcelona, 1986. http://hdl.handle.net/10803/32120.

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En esta tesis se desarrolla una metodología estadística que permite obtener clasificaciones de modelos linalizables a través de una distancia basada en el concepto de información de Shamon. Se han obtenido explícitamente expresiones algebraicas de los estimadores que nos sirvieron para comparar dos o mas de dichas curvas estableciendo su relación con los contrastes de hipótesis propias del análisis de la varianza en el caso de que las curvas fueran asociadas a un modelo lineal normal de varianzas iguales. Finalmente, y como aplicación, se hace un análisis y una clasificación de distintos tipos de respuesta al TTOG en una muestra de niños, dando posteriormente un método de diagnostico automatizado que cuantifica sus errores.

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El, Sanadi Caroline Elizabeth. "DEVELOPMENT AND VALIDATION OF CLINICAL PREDICTION TOOLS FOR AIDING IN SELECTION OF 2ND LINE THERAPIES ADDED TO METFORMIN IN TREATMENT OF TYPE 2 DIABETES". Case Western Reserve University School of Graduate Studies / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=case1607604907339227.

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Desjardins, Julie K. Balshine Sigal. "Behavioural ecology and endocrinology of cooperative breeding in the cichlid, neolamprologus pulcher". * McMaster only, 2006. http://proquest.umi.com/pqdweb?index=0&did=1367843081&SrchMode=1&sid=2&Fmt=2&VInst=PROD&VType=PQD&RQT=309&VName=PQD&TS=1194636578&clientId=22605.

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Söderström, Torbjörn. "Molecular endocrinology of target enzymes in androgen metabolism : implications for prostate cancer /". Stockholm : Karolinska Univ. Press, 2001. http://diss.kib.ki.se/2001/91-89428-12-9/.

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Stein, Ingrid Vera. "Monitoramento das oscilações anuais nos níveis de testosterona plasmática e andrógenos fecais de machos de jararaca-ilhoa (Bothrops insularis) mantidos em cativeiro". Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-06102016-162148/.

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A jararaca-ilhoa (Bothrops insularis) é uma serpente criticamente ameaçada, endêmica da Ilha da Queimada Grande (IQG), litoral sul de São Paulo. Com a sua população em declínio, foi estabelecido um programa de reprodução em cativeiro, porém o conhecimento da sua biologia reprodutiva ainda é incipiente. Até o momento considera-se essa espécie como sazonal, com período de espermatogênese e cópulas associado, ocorrendo do outono até início da primavera, porém não existem estudos a cerca da endocrinologia reprodutiva. O objetivo desse trabalho foi validar um método de avaliação hormonal não invasiva por meio das fezes e realizar o monitoramento dos metabólitos fecais de testosterona em conjunto com avaliação plasmática de testosterona. Ao longo de 36 meses foram coletadas 156 amostras de fezes e 30 amostras de sangue de oito machos cativos. As concentrações de metabólitos fecais de testosterona variaram entre 10,9 à 249,3 ng/g de fezes, enquanto as concentrações de testosterona plasmática variaram de 0,07 à 0,30 ng/mL de plasma. Não houve diferença significativa entre as concentrações plasmáticas de testosterona e de metabólitos fecais de testosterona ao longo do ano, apesar dos machos demonstrarem comportamento reprodutivo durante esse período. Os dados corroboram com outros estudos de estocagem espermática, qualidade seminal e volume gonadal, porém vão de encontro à resultados de histologia testicular. São discutidas a possibilidade da espécie ser assazonal ou desses resultados serem uma consequência das condições do cativeiro. Esse estudo contribui com a validação de um novo método de avaliação longitudinal de esteroides sexuais em B. insularis, com o conhecimento da biologia reprodutiva de serpentes tropicais e com a conservação de animais ameaçados de extinção
The golden lancehead pitviper (Bothrops insularis) is a critically endangered snake, endemic of the Queimada Grande Island, southeastern Brazil. With its declining population, a captive breeding program was established, but the knowledge of its reproductive biology is incipient. By the time this species is considered as seasonal, with spermatogenesis period and matting associated, occurring from autumn until early spring, but there are no studies about their reproductive endocrinology. The aim of this study was to validate a noninvasively hormonal evaluation method through feces and carry out the monitoring of androgens in conjunction with plasma testosterone evaluation. Over 36 months 156 stool samples and 30 blood samples were collected from eight captive males. The fecal androgen concentrations ranged from 10.9 to 249.3 ng / g of feces and the plasma testosterone concentrations ranged from 0.07 to 0.30 ng / mL of plasma. There was no significant difference between the concentrations of fecal androgens and plasma throughout the year, although the males had shown successfully reproductive behavior during this period. The data corroborate whith other studies of sperm storage, sperm quality and gonadal volume, but disagreeded of the results of testicular histology. We discuss the possibility of the species be assazonal or these results are a consequence of the captivity conditions. This study contributes to the validation of a new longitudinal evaluation method of sex steroids in B. insularis, with the knowledge of the reproductive biology of tropical snakes and the conservation of endangered animals

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