Rozprawy doktorskie na temat „Endocrine glands”
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Kasaian, Katayoon. "Genomic analysis of head and neck endocrine glands". Thesis, University of British Columbia, 2015. http://hdl.handle.net/2429/54936.
Pełny tekst źródłaScience, Faculty of
Graduate
Olsson, Tommy. "Endocrine studies in stroke patients". Doctoral thesis, Umeå universitet, Medicin, 1989. http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-101772.
Pełny tekst źródłaS. 1-66: sammanfattning, s. 69-190: 6 uppsatser
digitalisering@umu
Newey, Paul J. "The role of the tumour suppressor proteins, parafibromin and menin, in endocrine tumourigenesis". Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.711613.
Pełny tekst źródłaJones, Maren Bell. "Effects and interactions of endocrine disrupting chemicals and diet on the mouse reproductive system". Diss., Columbia, Mo. : University of Missouri-Columbia, 2007. http://hdl.handle.net/10355/5006.
Pełny tekst źródłaThe entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file (viewed on October 29, 2007) Vita. Includes bibliographical references.
Jacobsson, Gunilla. "Proteins regulating vesicular docking and fusion : histochemical studies on their presence and regulation in endocrine, neuroendocrine and neuronal cells /". Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2775-8.
Pełny tekst źródłaPark, June-Woo. "Development and validation of novel molecular techniques to elucidate mechanisms of endocrine disruption". Diss., Connect to online resource - MSU authorized users, 2008.
Znajdź pełny tekst źródłaTitle from PDF t.p. (viewed on Mar. 30, 2009) Includes bibliographical references. Also issued in print.
Lessey, Andrew James. "The role of C-type natriuretic peptides (CNP) on pituitary development and body growth in zebrafish : molecular investigations of neuroendocrine development". Thesis, Royal Veterinary College (University of London), 2016. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.701675.
Pełny tekst źródłaDwyer, Virginia Michelle Gregory 1955. "A STUDY OF PINEAL GLAND POLYPEPTIDES AND PROTEINS BY POLYACRYLAMIDE GEL ISOELECTRIC FOCUSING (PAG-IEF) AND TWO-DIMENSIONAL ELECTROPHORESIS (2DE) (BRAIN REGIONS)". Thesis, The University of Arizona, 1986. http://hdl.handle.net/10150/276560.
Pełny tekst źródłaChu, Xia. "Aspects of MEN1 Tumorigenesis in Endocrine Pancreas and Adrenal Glands". Doctoral thesis, Uppsala universitet, Endokrin Onkologi, 2015. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-254817.
Pełny tekst źródłaBatisweiler, Georgia. "Kognitive Leistungen bei Patienten mit angeborenen und erworbenen Hormonstörungen". München : Universität der Bundeswehr München, 1995. http://catalog.hathitrust.org/api/volumes/oclc/68945083.html.
Pełny tekst źródłaKrown, Kevin Alan. "Pituitary changes in force-molted hens". Diss., The University of Arizona, 1990. http://hdl.handle.net/10150/185205.
Pełny tekst źródłaSwart, Johannes Cornelius. "The development and implementation of biomarker assays for estrogenic endocrine disruptors". Thesis, University of the Western Cape, 2008. http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_6792_1258011445.
Pełny tekst źródła'Endocrine disrupting chemicals (EDCs) are compounds found in the environment that have the potential to disrupt normal endocrine function. Estrogenic EDCs (e-EDCs) is a subclass of EDCs and is defined as substances contaminating the environment that may mimic or inhibit the effect of endogenous estrogen and therefore may influence developmental and reproductive health in humans and animals. The aim of this study was to develop, validate and implement a battery of in vitro and in vivo screening assays for e-EDCs. The study was concluded by implementing this battery of assays to assess the Eerste River, South Africa at three sampling sites, namely Jonkershoek, Stellenbosch sewage treatment works (STW) effluent and Spier for e-EDCs. The control site, Jonkershoek contained very low levels of estrone. Water from this site showed no estrogenic activity when the E-screen and the ER_ induction in MCF-7 cells. Some of the water samples collected at this site tested positive for estrogenicity when analysed with the juvenile tilapia VTG assay, whereas the rest were negative. The estrone levels in the sewage effluent extracts as well as Spier were significantly higher. The assay using ER_ protein induction by the MCF-7 cell line, the MCF-7 proliferation assay and the tilapia in vivo screen for estrogenicity showed that these samples are estrogenic. Results obtained for estrogenicity at the three different sampling sites for each of the assays in the battery were comparable. In this study we developed, validated and also implemented a battery of assays encompassing both in vitro and in vivo assays, based on different biological mechanisms, to detect estrogenic EDCs. To our knowledge, this is the first study that has used a battery of bioassays to specifically assess a South Africa river for estrogenicity...'
Gaddis, Christine A. "Development and use of an in vivo mouse model system to assess the morphological effects of exposure to endocrine disrupting compounds in uterine and mammary tissue". Click here for download, 2008. http://proquest.umi.com/pqdweb?did=1633784231&sid=1&Fmt=2&clientId=3260&RQT=309&VName=PQD.
Pełny tekst źródłaTang, Pak-lai. "Studies on pineal and serum melatonin in mammals /". [Hong Kong : University of Hong Kong], 1986. http://sunzi.lib.hku.hk/hkuto/record.jsp?B12345891.
Pełny tekst źródłaPapoulias, Diana. "The effects of endocrine disrupting chemicals on the sexual development of fish /". free to MU campus, to others for purchase, 2001. http://wwwlib.umi.com/cr/mo/fullcit?p3036850.
Pełny tekst źródła鄧柏澧 i Pak-lai Tang. "Studies on pineal and serum melatonin in mammals". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 1986. http://hub.hku.hk/bib/B31230982.
Pełny tekst źródłaRaposo, João Filipe Cancela Santos. "A regulação endócrina dos balanços de cálcio". Doctoral thesis, Faculdade de Ciências Médicas. Universidade Nova de Lisboa, 2004. http://hdl.handle.net/10362/5523.
Pełny tekst źródłaZhang, Xiaowei. "Application of toxicogenomic approaches to study chemical-induced effects on the hypothalamic-pituitary-gonadal (HPG) axis of the Japanese medaka (Oryzias latipes)". Diss., Connect to online resource - MSU authorized users, 2008.
Znajdź pełny tekst źródłaTitle from PDF t.p. (viewed on Mar. 30, 2009) Includes bibliographical references. Also issued in print.
Ghebrealfa, Kahsai Negassi. "Chemical characterisation of the uropygial secretion of Rhinopomastus cyanomelas". Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/53731.
Pełny tekst źródłaENGLISH ABSTRACT: The uropygial gland of most birds produces a variety of hydrocarbons, lipids, waxes, fatty acids, alcohols and other organic compounds. These compounds have two widely recognized functions, viz. they are considered essential for the maintenance of a good plumage condition, and may be used for fungicidal, bactericidal or other hygienic purposes. Scimitar-billed woodhoopoes, Rhinopomastus cyanomelas, are groupterritorial birds that live in groups comprising between two and twelve individuals. Individuals enter the roost cavities shortly after sunset and exit the following morning soon after sunrise. During the period that the birds are inside the roost, they are vulnerable to a range of vertebrate predators, including snakes, genets and rats. When disturbed while roosting, woodhoopoes immediately face away from the threat hence presenting their uropygial glands in the direction of the threat. Typically, a drop of brown, highly pungent secretion is then formed at the tip of the papilla to the uropygial gland, and kept in place by a few tuft-like feathers. This response pattern has led some observers to believe that the secretion serves an anti-predatory role. It has been found that the synthetic volatile constituents of the uropygial secretion of the green woodhoopoe, P. purpureus, individually or as a mixture, have potent defensive properties against feline and reptilian predators. In addition, the compounds also showed activity against a range of bacteria. The aim of the present study was to determine the chemical composition of the uropygial secretion of the scimitar-billed woodhoopoe, Rhinopomastus cyanomelas, as a first step towards the evaluation of, inter alia, the semiochemical function of the secretion. Using gas chromatography-mass spectrometry, 179 constituents of the uropygial secretion of the scimitar-billed woodhoopoe have been identified. The majority of the constituents of the secretion are branched and unbranched aldehydes (aliphatic and aromatic), acids (aliphatic and aromatic), sulfides and ketones. This group of volatile compounds is responsible for the obnoxious odour of the secretion and possibly also for its defensive action against predators. The secretion also contains a large number of branched and unbranched alkanes and wax esters. The chemical composition of the secretion was compared with the secretion of P. purpureus as well as with that of the hoopoe, Upupa africana. The uropygial gland secretion of the scimitar-billed woodhoopoe is quite similar to that of the green woodhoopoe, although it is much more complex than that of the green woodhoopoe. In contrast to the uropygial secretions of the green and the scimitar-billed woodhoopoes, the secretion of Upupa africana does not have a strongly obnoxious odour and it also does not contain large quantities of alkanes and wax esters.
AFRIKAANSE OPSOMMING: Die uropigiale klier van die meeste voëls produseer 'n verskeidenheid van koolwaterstowwe, lipiede, was-esters, vetsure, alkohole en ander organiese verbindings. Hierdie verbindings het twee algemeen erkende funksies, naamlik die instandhouding van die goeie kondisie van die vere, en 'n swam- en kiemdodende werking. Swartbekkakelaars (Engels: scimitar-billed woodhoopoes ), Rhinopomastus cyanomelas, is groep-territoriale voëls wat in groepe van tussen twee en twaalf saam woon. Individue gaan hul neste net na sononder binne en verlaat dit weer die volgende oggend net na sonsopkoms. Terwyl die voëls binne die neste is, is hulle kwesbaar ten opsigte van aanval deur verskeie gewerwelde roofdiere, insluitende slange, muskeljaatkatte en rotte. Wanneer hulle in hul neste gesteur word, sal kakelaars onmiddellik wegdraai van die bedreiging sodat die uropigiale klier in die rigting van die bedreiging gekeer is. 'n Druppel bruin, uiters onwelriekende afskeiding vorm dan by die punt van die papil na die uropigiale klier, en word in posisie gehou deur 'n verekwassie. Hierdie gedragspatroon het aanleiding gegee tot die gedagte by sommige waarnemers dat die afskeiding as afweerstof teen roofdiere dien. Daar is gevind dat die sintetiese vlugtige komponente van die uropigiale afskeiding van die groenkakelaar, P. purpureus, individueel of as 'n mengsel, sterk afweer-eienskappe teen katte en reptiele toon. Daarbenewens het die verbindings ook aktiwiteit getoon teen 'n reeks van bakterieë. Die doel van die huidige studie was om die chemiese samestelling van die uropigiale afskeiding van die swartbekkakelaar, Rhinopomastus cyanomelas, te bepaal as 'n eerste stap met die oog op die evaluering van, onder andere, die semiochemiese funksie van die afskeiding. Deur van gaschromatografie-massaspektrometrie gebruik te maak, is 179 komponente van die uropigiale afskeiding van die swartbekkakelaar geïdentifiseer. Die meeste van die komponente is vertakte en onvertakte aldehiede (alifaties en aromaties), sure (alifaties en aromaties), sulfiede en ketone. Hierdie groep vlugtige verbindings is verantwoordelik vir die afstootlike reuk van die afskeiding en waarskynlik ook vir sy afweer-aksie teen roofdiere. Die afskeiding bevat ook 'n groot aantal vertakte en onvertakte alkane en wasesters. Die chemiese samestelling van die afskeiding is vergelyk met die van P. purpureus sowel as dié van die hoepoe, Upupa africana. Die uropigiale klierafskeiding van die swartbekkakelaar stem tot 'n groot mate ooreen met dié van die groenkakelaar, alhoewel dit veel meer kompleks is as dié van die groenkakelaar. In teenstelling met die uropigiale afskeidings van die groen- en die swartbekkakelaars, het die afskeiding van Upupa africana nie 'n afstootlike reuk nie en bevat dit ook nie groot hoeveelhede alkane en was-esters nie.
Chan, Chin-ho. "Signalling pathways of M918T RET mutant in multiple endocrine neoplasia type 2B". Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B34603244.
Pełny tekst źródłaWheeler, Michael Brent. "The effect of total parenteral nutrition on pancreatic and gastric endocrine secretion". Thesis, University of British Columbia, 1988. http://hdl.handle.net/2429/29449.
Pełny tekst źródłaMedicine, Faculty of
Cellular and Physiological Sciences, Department of
Graduate
Örn, Stefan. "The zebrafish as a model organism for evaluation of endocrine disrupters /". Uppsala : Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, 2006. http://epsilon.slu.se/200628.pdf.
Pełny tekst źródła陳展豪 i Chin-ho Chan. "Signalling pathways of M918T RET mutant in multiple endocrine neoplasia type 2B". Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B34603244.
Pełny tekst źródłaScott, Gary Terri. "The role of micro-organisms in the production of semiochemicals in the interdigital secretion of the bontebok, Damaliscus pygargus pygargus". Thesis, Stellenbosch : Stellenbosch University, 2004. http://hdl.handle.net/10019.1/53774.
Pełny tekst źródłaENGLISH ABSTRACT: Bontebok, Damaliscus pygargus pygargus, formerly classified as D. dorcas dorcas, are territorial animals with interdigital glands between the toes of the forelegs. Males regularly defecate on dung heaps, on which they often lie, to communicate with other members of their species. They also communicate by means of visual displays, scent marking and occasionally with scraping or pawing of dung heaps. It is assumed that scent marking with the interdigital secretion serves to define territories frequented by these antelope. These glands secrete a complex mixture of volatile and non-volatile compounds and the volatile compounds in the secretion serve as a chemical signal for other bontebok. It has been suggested that the interdigital secretion is not produced in its final composition by the interdigital gland alone, but that microbial activity is responsible for many of the compounds present in the secretion. In general, many compounds can be attributed to the by-products of microbial hydrolysis of triglycerides, a common characteristic of sebum. It is well documented that micro-organisms inhabit the deep recesses of sebaceous glands and the presence of micro-organisms has been found to be consistent in all antelope exocrine glandular areas. This study involved the chemical characterisation of the volatile metabolites produced in vitro by micro-organisms from the interdigital cavity of the bontebok. Various comparative studies were made, one of which was comparison of the metabolites produced by the individual microbial species as well as the total community of bacteria incubated in different media. A comparison of the compounds identified in the interdigital secretion and the metabolites produced by the micro-organisms in the different media was also made. The volatile metabolite extracts of the individual bacterial species and of the total community were chemically characterised by low-resolution gas chromatography-mass spectroscopy. Classes of compounds identified from the volatile metabolite extracts include: • Acids - Aliphatic (saturated and unsaturated) • Alcohols - Aliphatic (saturated and unsaturated) • Aldehydes - Aliphatic (saturated and unsaturated) • Aromatic compounds • Ketones - Aliphatic (saturated and unsaturated) • Pyrazines • Dimethyldisulphide • Squalene and cholesterol Several qualitative differences were found between the compounds identified in the volatile metabolite extracts of the micro-organisms when incubated in tryptic soy broth (TSB) and minimal salt medium (MSM). In particular, when the microbes were incubated in TSB medium a number of pyrazines were found that were not present when utilising MSM as a medium. Additional qualitative differences were found between the compounds identified in the metabolite extracts of the individual bacterial species and the total community of bacteria, when incubated in both TSB and MSM media. A comparison of the interdigital secretion and the metabolite extracts of the microbial communities incubated in TSB and MSM revealed that many compounds produced in MSM corresponded to the compounds identified in the interdigital secretion. These corresponding compounds were found to be saturated and unsaturated acids, aldehydes and squalene. Furthermore, there was only one corresponding compound in the case of TSB as medium.
AFRIKAANSE OPSOMMING: Die bontebok, Damaliscus pygargus pygargus, voorheen geklassifiseer as D. dorcas dorcas, is 'n territoriale dier met interdigitale kliere tussen die kloutjies van die voorpote. Ramme ontlas gereeld op mishope, waarop hulle dikwels lê, om met ander lede van die spesie te kommunikeer. Hulle kommunikeer ook deur middel van visuele seine, reukmerking en soms deur mishope met die voorpote te kap of te skraap. Reukmerking met die interdigitale afskeiding dien klaarblyklik om gebiede wat deur hierdie diere bewoon word, af te baken. Die interdigitale kliere skei 'n komplekse mengsel van vlugtige en nie-vlugtige verbindings af en die vlugtige verbindings dien as chemiese sein vir ander bontebokke. Die vermoede bestaan dat die interdigitale klier nie alleen verantwoordelik is vir die finale samestelling van die interdigitale afskeiding nie, maar dat mikrobiese aktiwiteit bydra tot die produksie van baie van die verbindings wat in die afskeiding aanwesig is. Sekere verbindings kan in die algemeen toegeskryf word aan die vorming van die neweprodukte van mikrobiese hidrolise van trigliseriede, 'n algemene eienskap van sebum. Dit is bekend dat die diep holtes van vetkliere 'n goeie teelaarde is vir mikroorganismes en daar is gevind dat mikroorganismes feitlik deurgaans voorkom in alle anteloop eksokriene klierareas. Hierdie studie behels die chemiese karakterisering van die vlugtige metaboliete wat in vitro deur mikroorganismes van die interdigitale klierholte van die bontebok geproduseer word. Verskeie vergelykende studies is uitgevoer waarvan een die vergelyking was van die metaboliete wat deur die individuele mikrobiese spesies sowel as die totale gemeenskap van bakterieë geproduseer word tydens inkubasie in verskillende media. Vergelyking van die verbindings wat in die interdigitale afskeiding geïdentifiseer is met die metaboliete wat in verskillende media geproduseer is, het ook deel van die studie uitgemaak. Die vlugtige metaboliet ekstrakte van die individuele bakteriese spesies en van die totale gemeenskap is chemies gekarakteriseer deur middel van laeresolusie gaschromatografie-massaspektrometrie. Die volgende groepe verbindings is onder andere in die vlugtige metaboliet ekstrakte geïdentifiseer: • Sure - Alifaties (versadig en onversadig) • Alkohole - Alifaties (versadig en onversadig) • Aldehiede - Alifaties (versadig en onversadig) • Aromatiese verbindings • Ketone - Alifaties (versadig en onversadig) • Pirasiene • Dimetieldisulfied • Skwaleen en cholesterol Verskeie kwalitatiewe verskille is gevind tussen die verbindings wat geïdentifiseer is in die vlugtige metaboliet ekstrakte van die mikroorganismes onderskeidelik in TSB medium en MSM geïnkubeer. Opvallend was byvoorbeeld die voorkoms van pirasiene in gevalle waar mikroorganismes in TSB medium geïnkubeer is, terwyl hierdie groep verbindings afwesig was wanneer MSM gebruik is. Onderlinge kwalitatiewe verskille is ook gevind tussen die verbindings wat geïdentifiseer is in die metaboliet ekstrakte van die individuele bakteriese spesies en die totale gemeenskap van bakterieë, wanneer in TSB medium sowel as in MSM geïnkubeer is. Vergelyking van die verbindings in die interdigitale afskeiding en in die metaboliet ekstrakte van die mikrobiese gemeenskappe, het getoon dat 'n aantal verbindings wat in MSM geproduseer is, ooreenstem met verbindings wat in die interdigitale afskeiding geïdentifiseer is. Daar is gevind dat hierdie verbindings versadigde en onversadigde sure en aldehiede en skwaleen is. Met TSB as medium was daar slegs een ooreenstemmende verbinding.
Antonica, Francesco. "Modelling thyroid embryogenesis using embryonic stem cells". Doctoral thesis, Universite Libre de Bruxelles, 2013. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209551.
Pełny tekst źródłaFor the identification of new genes and molecular events controlling thyroid organogenesis it would be useful to develop an in vitro cellular model to recapitulate thyroid embryogenesis in a dish. Embryonic Stem Cells (ESCs) have recently emerged as system model to recapitulate the embryogenesis of several tissues in vitro.
Induced overexpression of defined transcription factors has been shown to have a directing effect on the differentiation of pluripotent stem cells into specific cell types. In this thesis I show that a transient overexpression of the transcription factors NKX2.1 and PAX8 is sufficient to direct the differentiation of murine ESCs into thyroid follicular cells (TFC) and promotes in vitro self- assembly of TFC into three-dimensional follicular structures, when associated to a subsequent thyrotropin (TSH) treatment. Cells differentiated by this protocol showed significant iodide organification activity, a hallmark of thyroid tissue function. Importantly, athyroid mice grafted with mESC-derived thyroid follicles show normalization of plasma T4 levels with concomitant decrease of plasma TSH. In addition, a full normalization of body temperature at 4 weeks after transplantation was observed. Together, these data clearly demonstrate that grafting of our mESC-derived thyroid cells rescues the hypothyroid state and triggers symptomatic recovery along with the normalization of plasma hormone concentrations. The high efficiency of TFC differentiation and follicle morphogenesis in our system will provide an unprecedented opportunity for future studies to decipher regulatory mechanisms involved in embryonic thyroid development, a major research need towards an improved understanding of the molecular mechanisms underlying congenital hypothyroidism, the most common congenital endocrine disorder in humans.
Doctorat en Sciences biomédicales et pharmaceutiques
info:eu-repo/semantics/nonPublished
NAGAMATI, LUCIO T. "Marcação do peptídeo DOTA-Tyrsup(3)-octreotato com radioiodo e estudo da biodistribuição e afinidade por células de tumor neuroendócrino AR42J em camundongos". reponame:Repositório Institucional do IPEN, 2006. http://repositorio.ipen.br:8080/xmlui/handle/123456789/11483.
Pełny tekst źródłaMade available in DSpace on 2014-10-09T14:01:44Z (GMT). No. of bitstreams: 0
Dissertação (Mestrado)
IPEN/D
Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP
Clubbs, Rebekah L. Brooks Bryan William. "Multigenerational responses of Daphnia magna to Ethynylestradiol and Faslodex". Waco, Tex. : Baylor University, 2005. http://hdl.handle.net/2104/2881.
Pełny tekst źródłaBiondi, Christine A. "Mouse models of multiple endocrine neoplasia type 1 (MEN 1)". Thesis, Queensland University of Technology, 2002.
Znajdź pełny tekst źródłaCosta, Teresa Raquel Grade Godinho Peladinho. "Clínica e cirurgia de animais de companhia". Master's thesis, Universidade de Évora, 2018. http://hdl.handle.net/10174/24370.
Pełny tekst źródłaMarchand, André. "Opothérapie : émergence et développement d’une technique thérapeutique (France, 1889-1940)". Thesis, Paris, CNAM, 2014. http://www.theses.fr/2015CNAM0980/document.
Pełny tekst źródłaLaunched by a communication from the famous Professor Brown-Sequard in 1889 on the effects of self-injection of testicular juice, organotherapy – a technique of care using the juice of glands – falls within a long tradition of animal medication. Publications of doctors and pharmacists have allowed us to establish how the new treatment is part of the landscape of medicine that became more scientific at the turn of the nineteenth and twentieth centuries. Opotherapy/Organotherapy, whose development depends on the development of knowledge on the endocrine glands, develops through therapeutic successes in thyroid and gynecological diseases and by making pharmaceuticals produced by industrializing pharmacists which provided medication in a form that eliminates a medical procedure, available to the public. Organotherapy, which stands out from hormone therapy by the use of natural misidentified drugs that have generated a great number of debates on their composition and mode of action, will know its greatest development around the First World War and will persist despite the development of hormone therapy based on synthetic molecules until the 1990s
Monges-Ranchin, Geneviève. "Les cellules endocrines de l'estomac et leur pathologie". Aix-Marseille 2, 1987. http://www.theses.fr/1987AIX21917.
Pełny tekst źródłaHurter, Etienne. "Biochemical and physiological changes associated with estrogenic activity in Xenopus laevis : a model for the detection of endocrine disruption". Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53309.
Pełny tekst źródłaENGLISH ABSTRACT: Concern has increased that widespread adverse effects are occurring in humans and wildlife populations as a result of exposure to environmental chemicals (mostly man-made) that disrupt the normal functioning of the endocrine system. Many pharmaceutical, agricultural and industrial chemicals, acting as endocrine modulating compounds (EDCs), have been detected in an accumulated form in food, in drinking water and in the environment. Although the levels of these chemicals can be measured analytically, it is important to evaluate biological activity. For this, animal models are used and relevant bioassays developed. These assays are based on biological markers, which are specific xenobiotically-induced physiological responses and are usually deviations in cellular or biochemical components, processes or structures. Vitellogenin is a large protein complex, produced in the liver under estrogen control and circulates in the plasma, destined for incorporation into the developing oocyte in female oviparous vertebrates. Since vitellogenin production is low or nonexistent in males, its presence may therefore be interpreted as evidence of exposure to estrogenic environmental contaminants. In this study the African Clawed Frog, Xenopus laevis was used as model to study the effects of estrogens on biochemical and physiological parameters associated with vitellogenesis. As a starting point the seasonal female reproductive cycle in a natural Xenopus laevis population in terms of ovarian state, plasma vitellogenin and plasma estrogen levels was studied. It was shown that plasma vitellogenin and estrogen levels were seasonal and correlated to a seasonal ovarian cycle, which peaked during spring. However, although seasonality existed, there were reproductively active individuals at any time during the year. Increases in plasma estrogen levels predated increases in plasma vitellogenin levels and ovarian maturation. Lipoprotein profiles, as well as plasma cholesterol, triglyceride and phospholipid concentrations were determined and it was shown that estrogen affected these in such a way that these parameters could be used as additional markers in estrogen contamination studies. In order to develop an in vitro bioassay to screen for estrogenic activity, the use of hepatic tissue cultures was investigated. Optimal culture conditions were established and increased sensitivity in the estrogenic response was obtained by using liver slices from male frogs that were pre-treated with estrogen. Validation studies proved that this bioassay could be employed for routine screening of water and chemical samples. In order to refine the Xenopus laevis vitellogenin ELISA and liver slice bioassay, existing polyclonal anti-vitellogenin antibodies were replaced by culturing monoclonal antibodies. Selected antibodies were characterised and ELISAs developed and validated. This study showed that the newly developed Xenopus laevis vitellogenin ELISA and liver slice bioassay have the potential to be employed in environmental monitoring programmes.
AFRIKAANSE OPSOMMING: Daar is toenemende besorgdheid dat afwykings in mens- en dierbevolkings voorkom as gevolg van blootstelling aan chemikalieë (hoofsaaklik mensgemaak) in die omgewing wat die normale werking van die endokrienstelsel versteur. Verskeie farmaseutiese, landbou- en industriële chemikalieë, wat as endokrienversteurders optree, is in die omgewing gevind. AI kan die vlakke van hierdie stowwe analities bepaal word, is dit belangrik om hulle biologiese aktiwiteit te evalueer. Hiervoor word diermodelle aangewend om toepaslike toetse daarvoor te ontwikkel. Hierdie toetse word baseer op biologiese merkers, spesifieke xenobioties-geïnduseerde fisiologiese reaksies, en is gewoonlik afwykings van sellulêre- of biochemiese komponente, -prosesse of - strukture. Vitellogeen ('n dooiervoorloper) is 'n lipoproteïenkompleks wat, onder estrogeenbeheer, in die lewer vervaardig word en in die plasma sirkuleer vir uiteindelike inkorporasie in ontwikkelende oësiete van vroulike, ovipare werweldiere. Aangesien daar min of geen vitellogeen in manlike diere geproduseer word, is die teenwoordigheid daarvan 'n aanduiding dat die dier aan estrogeniese omgewingsbesoedeling blootgestel is. In hierdie studie is die Platanna, Xenopus laevis, as model gebruik om die gevolge van estrogene op biochemiese en fisiologiese veranderlikes, wat met vitellogenese geassosieer word, te bestudeer. As vertrekpunt is die seisoenale voortplantingsiklus van die wyfie, in terme van vitellogeen en -estrogeen vlakke in die plasma en aktiwiteit van die ovaria bepaal. Daar is aangetoon dat die estrogeen- en vitellogeenvlakke in die plasma met die ovariumsiklus, wat gedurende die lente hoogtepunte bereik, korreleer. Alhoewel daar seisoenaliteit bestaan, was daar dwarsdeur die jaar wyfies wat ovarium dooierneerlegging getoon het. Verhoging in estrogeenvlakke het vitellogeenpieke en rypwording van die ovaria voorafgegaan. Lipoproteïenprofiele, sowel as die cholesterol- , trigliseried- en fosfolipiedkonsentrasies in die plasma is bepaal en daar is aangetoon dat estrogeen hierdie medeveranderlikes in só 'n mate affekteer dat hulle as bykomende biomerkers vir estrogeenblootstelling in besoedelingstudies gebruik kan word. In vitro Xenopus laevis lewersnitte in die weefselkultuur omgewing is ondersoek om 'n biotoets te onwikkel vir die gebruik in vinnige estrogenisiteits-toetsing van watermonsters en chemise stowwe. Die mees gunstige kultuurtoestande is bepaal en die sensitiwiteit van estrogeenreaksies is verhoog deur lewer van mannetjies, wat vooraf met estrogeen behandel is, te gebruik. Hierdie biotoets se geldigheid is gestaaf en kan in roetine eerstevlaktoetsing van watermonsters gebruik word. Die gebruik van poliklonale teenliggaampies in 'n bestaande enzyme-linked immunosorbent assay (ELISA) is vervang deur spesiaal-ontwikkelde monoklonale anti-Xenopus laevis vitellogeen teenliggaampies. Uitgesoekte teenliggaampies, spesifiek teen die estrogeengeïnduseerde proteïene, is gekarakteriseer en ELISAs saamgestel en die geldigheid gestaaf. Hierdie studie het aangetoon dat die nuut-onwikkelde Xenopus laevis vitellogeen-ELISA en lewerkultuurbiotoets die potensiaal het om In omgewingsmoniteringprogramme gebruik te word.
Kohler, Romain. "Collection de cas d'auto-enseignement en imagerie des glandes endocrines (thyroïde, parathyroïdes, surrénales, pancréas endocrine) /". Genève : [s.n.], 2006. http://www.unige.ch/cyberdocuments/theses2006/KohlerR/these.pdf.
Pełny tekst źródłaHIGUTI, ELIZA. "Correção fenotípica do nanismo avaliada por diferentes parâmetros de crescimento após administração de DNA plasmidial em modelo animal de deficiência isolada do hormônio do crescimento". reponame:Repositório Institucional do IPEN, 2016. http://repositorio.ipen.br:8080/xmlui/handle/123456789/26374.
Pełny tekst źródłaMade available in DSpace on 2016-06-22T11:39:54Z (GMT). No. of bitstreams: 0
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
Tese (Doutorado em Tecnologia Nuclear)
IPEN/T
Instituto de Pesquisas Energeticas e Nucleares - IPEN-CNEN/SP
FAPESP:11/21708-6
Moura, Carlos Eduardo Bezerra de. "Expressão do VEGF e vascularização do corpo lúteo em búfalos". Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/10/10132/tde-29042004-172124/.
Pełny tekst źródłaCorpus luteum is a temporary organ, which regulates the estrous cycle and pregnancy; it is extremely dependent on vascularization. During corpus luteum life span P4 production is associated with an increase of capillary number known as angiogenesis. The angiogenic process is modulated by many factors, including VEGF (vascular endothelial growth factor), which is considered the most important of them. Hyperstimulation of ovarian function, a largely spread technique employed in cattle raising, is associated with high levels of estradiol and P4, as well as an increase of capillary invasion of the new formed CL. This study intended to quantify the vascularization of normal and superovulated corpora lutea (CLL), trying to correlate this parameter with blood P4 concentrations and expression of VEGF and its receptors. For that purpose thirty buffalo cows were divided into five groups: superovulated (received 400 mg FSH divided in decreasing doses of 80 mg, 60 mg, 40 mg e 20mg 12/12h during 4 days), corpus hemorragicans (CH), mature corpus luteum (CL), regression CL (CR) e corpo albicans (CA), that received no treatment and were slaughtered at days 2, 9, 17 and 26 after ovulation. After slaughter ovaries were collected and corpora lutea prepared as follows: three animals from each group had their CLL fixed in buffered formol solution, cut into 0,5 cm pieces, dehydrated in increasing ethanol concentrations, cleared in xylene and embedded in paraffin using conventional procedures. Five µm slices were prepared for quantification of vascular density and immunolocalization of VEGF, VEGFR-1 and VEGFR-2. The ovaries of the remaining animals were injected with Mercox resin through ovarian artery in order to have the microvascularization evaluated by electron scanning microscopy. Blood samples were collected and P4 measured through conventional RIE. Capillary density during CL life span was 37,78 ± 8,89; 17,8 ± 3,33; 11,9 ± 3,57; 10,83 ± 2,42 and 3,46 ± 1,66 vessels/ mm2 respectively for superovulated (CS), CH, CL, CR and CA, indicated higher vascularization (p<0,001) for superovulated group. The microvasculature showed similar behavior: the density of capillary network was higher in CLL of superovulated animals. Values of serum progesterone were significantly higher (p<0,05) for CS animals: 5,58 ± 0,97 ng/ml vs 2,02 ± 0,16 ng/ml for control animals in the same stage of estrous cycle. The VEGF system and its receptors (VEGFR-1 e VEGFR-2) were immunolocalized in CLL of buffalo cows. The immunoreactivity could be detected in endothelial and luteal cells since day two post ovulation (p.o.) until the stage of regression corpus luteum (Day 17 p.o.), with strong immunostaining at the early and midluteal phase. The immunostaining was more intense in CLL of animals submitted to superovulation.
Tochetto, Camila. "Lesões de adrenais e neoplasmas de tireoide em cães". Universidade Federal de Santa Maria, 2015. http://repositorio.ufsm.br/handle/1/4111.
Pełny tekst źródłaThis thesis involved the study of the adrenal and thyroid glands. The study of adrenals was based, primarily, on epidemiological and pathological aspects of the lesions observed in the glands of 300 dogs necropsied in the Laboratório de Patologia Veterinária at the Universidade Federal de Santa Maria (LPV/UFSM). For this purpose, a prospective study was performed from March 2012 to June 2013, totaling 16 months. Of the 300 dogs examined, 82% had one or more adrenal lesions. Only 18% of these dogs did not have adrenal changes. The hyperplastic lesions were the most prevalent, comprising 91.5% of the cases, followed by degenerative (26%), circulatory (20.3%), neoplastic (15%), inflammatory (4.1%) and other lesions (14.2%). Most of the animals with hyperplastic lesions consisted of females, elderly and purebred dogs. Fatty degeneration was the most common degenerative lesion (54.7%). Among the neoplastic changes, primary tumors were the most prevalent (75.7%), with a prevalence of adenomas (57.1%), followed by pheochromocytomas (25%) and cortical carcinomas (17.9%). Metastatic tumors corresponded to 24.3% of all cases of neoplastic changes. The adrenal glands were the site of metastasis of mammary gland carcinoma, osteosarcoma, melanoma, lymphoma, cholangiocarcinoma, histiocytic sarcoma and lung adenocarcinoma. Under "other lesions", adrenal of stress was the most prevalent change (37.1%). It was characterized histologically by a cortex with irregular appearance. For the study of thyroid lesions, it was reviewed the protocols of biopsies and necropsies performed at the LVP/UFSM between 2004 and 2014, and all cases of thyroid tumors were selected. Epidemiological data, clinical significance of tumors, presence of cervical swelling, affected lobes, tumor size, presence and location of metastasis and histological pattern of the neoplasm. It were recorded 26 tumors of the thyroid gland. Of the affected dogs, 53.9% were females and 46.1% were males; 65.4% were purebred. Of these, Boxers were the most affected (15.4%). In 23 protocols the age was informed; 60.9% of the dogs were elderly and 39.1% were adults. The protocols evaluation allowed establishing that 38.5% of the animals had shown cervical swelling, at the time of clinical examination. From the dogs that underwent to necropsy, only 13.6% died or were euthanized due to complications caused by metastases of thyroid tumors. Thus, in 86.4% of the dogs, the neoplasms were considered as incidental necropsy findings. Glandular unilateral involvement occurred in 75% of the dogs. The histological diagnosis of primary tumors showed that 61.5% of the neoplasms were classified as follicular cell carcinomas, 23.1% as follicular cell adenomas, 7.7% as carcinosarcomas and 7.7% as tumors of C cell. Additionally, two cases of thyroid follicular cell carcinoma in dogs that developed myelopathy secondary to cervical spinal epidural metastasis were minutely evaluated, and separately reported.
Esta tese envolveu o estudo das adrenais e da tireoide. O estudo das adrenais baseou-se, principalmente, nos aspectos epidemiológicos e patológicos das lesões observadas nas glândulas de 300 cães necropsiados no Laboratório de Patologia Veterinária da Universidade Federal de Santa Maria (LPV/UFSM). Esse estudo foi realizado de forma prospectiva, de março de 2012 a junho de 2013. Dos 300 cães analisados, 82% tinham uma ou mais alterações nas adrenais e 18% não tinham alterações. As lesões hiperplásicas foram as mais prevalentes, com 91,5% das ocorrências, seguidas de lesões degenerativas (26%), circulatórias (20,3%), neoplásicas (15%), inflamatórias (4,1%) e outras lesões (14,2%). A maioria dos animais que apresentou lesões hiperplásicas era constituída de fêmeas, idosos e cães com raça definida. A degeneração gordurosa foi a lesão degenerativa mais frequente (54.7%). Entre as alterações neoplásicas, tumores primários foram mais prevalentes (75,7%), com predomínio de adenomas (57,1%), seguido de feocromocitomas (25%) e carcinomas corticais (17,9%). Os tumores metastáticos perfizeram 24,3% dos casos de alterações neoplásicas. As adrenais foram sítio de metástase de carcinoma mamário, osteossarcoma, melanoma, linfoma, colangiocarcinoma, sarcoma histiocítico e adenocarcinoma pulmonar. No item outras lesões , adrenal de estresse foi a alteração mais prevalente (37,1%). Essa alteração era caracterizada histologicamente por córtex de aspecto variegado. Para o estudo das lesões de tireoide foram revisados os protocolos de biópsias e necropsias do LPV/UFSM entre os anos de 2004 e 2014 e todos os casos de tumores tireoidianos foram selecionados. A partir disso, foram anotados dados epidemiológicos, significado clínico dos tumores, presença de aumento de volume cervical, lobos afetados, tamanho, presença e localização de metástases e padrão histológico dos neoplasmas. Foram diagnosticados 26 neoplasmas tireoidianos. Dos cães acometidos, 53,9% eram fêmeas e 46,1% eram machos; 65,4% eram cães com raça definida. Desses, Boxers foram os mais afetados (15,4%). Dos 23 protocolos em que a idade foi informada, 39,1% eram cães adultos e 60,9% eram idosos. A avaliação dos protocolos permitiu constatar que 38,5% dos animais haviam apresentado aumento de volume cervical no momento do exame clínico. Apenas 13,6% dos cães necropsiados morreram ou foram submetidos à eutanásia em decorrência de complicações causadas por metástases dos tumores de tireoide. Dessa forma, em 86,4% dos cães os neoplasmas foram considerados achados incidentais de necropsia. O acometimento unilateral da glândula ocorreu em 75% dos cães. Os diagnósticos histológicos dos tumores primários permitiram constatar que 61,5% dos neoplasmas eram carcinomas de células foliculares, 23,1% eram adenomas de células foliculares, 7,7% eram carcinossarcomas e 7,7% eram tumores de células C. Além disso, foram estudados de forma detalhada e relatados separadamente dois casos de carcinoma de células foliculares da tireoide em que os cães desenvolveram mielopatia secundária à metástase epidural cervical espinhal.
Fourie, Shani. "An assessment of water quality and endocrine disruption activities in the Eerste/Kuils River catchment system, Western Cape, South Africa". Thesis, Stellenbosch : Stellenbosch University, 2005. http://hdl.handle.net/10019.1/20917.
Pełny tekst źródłaENGLISH ABSTRACT: Water quality analysis forms the basis in assessing and monitoring catchments. As urban development continuously increase, pollution sources increase in either point source (wastewater treatment works, industrial effluents) and/or non-point source origin (storm water discharge, domestic pollutants), accumulating pollutants in the environment. It was only recently discovered that certain pollutants have subtle disrupting effects on the endocrine system resulting in health related problems associated with the reproductive system and thyroid system (growth and development) of animals and potentially humans. Natural water resource management proves to include limited biological assays measuring endpoints for cytoxicity, inflammatory activity and endocrine disruption. The broad objective of this study was therefore to include several bioassays, not normally used in municipal (City of Cape Town) monitoring programmes, along with water quality data collected by the City of Cape Town. The Eerste/Kuils River catchment system, Western Cape, under the auspices of the City of Cape Town was chosen, and although this catchment does not contribute to drinking water resources, is subjected to a range of anthropogenic influences (industrial effluents, household wastewater, agricultural runoff). Within the short time-frame available for this study (six months) two months, July (following a dry summer and autumn season) and October (following a wet winter and early spring season) were selected for water quality monitoring. Spatial variation (with relevance to specific point and non-point contamination) among sampling sites were also obtained by choosing several (n=10) along the catchment. Specific aim of the study therefore included: Firstly (Chapter 2), the use of in vitro bioassays, lactate-dehydrolises assay (LDH) for cytotoxic activity, pro-inflammatory hormone Interleukin-6 (IL-6) secretion by human blood cells and a specific Salmonella ELISA for faecal contamination, in conjunction with routine chemical and biological (mostly microbiological) monitoring activities. The study indicated significant variation among sites in all microbiological measures as well in IL-6 secretion and Salmonella presence. Between months, variations were also evident in certain variables. Secondly (Chapter 3), two bioassays using the yolk precursor protein, vitellogenin (Vtg) as endpoint was implemented in a) an in vitro Xenopus laevis liver slice assay (five day exposure) and b) an in vivo Zebrafish (Danio rerio) bioassay (seven day exposure) assessing estrogenic activity in the Eerste/Kuils River catchment. Although estrogen spiked positive control water samples stimulated Vtg production in vitro as well as in vivo, no dramatic estrogenic activity was measured at any of the selected sites. Thirdly (Chapter 4), a bioassay using the thyroid controlled metamorphosis in Xenopus laevis tadpoles to assess effects on the thyroid hormonal system was implemented. Thyroid stimulatory activity, compared with a negative control sample, was measured at two sites along the catchment. Although the practical implementation of the tadpole semi-static exposure protocol (water replacement) proved to be labour intensive, all the added bioassays proved to be valuable tools to add valuable information regarding water quality. It is clear that more research related to anthropogenic influences along the Eerste/Kuils River catchment system are needed, specifically in monitoring monthly variations to better understand annual variation in several of the endpoints studied.
AFRIKAANSE OPSOMMING: Waterkwaliteit vorm die basis vir die evaluering en monitering van opvangsgebiede. Voortdurende stedelike ontwikkeling gee aanleiding tot ‘n toename in die voorkoms van besoedelstowwe in die natuurlike omgewing deur gelokaliseerde (punt) bronne (rioolwerke/industriële uitvloeisel) en/of nie gelokaliseerde (nie punt) bronne (vloed uitlaat/huishoudelike uitvloeisels) van besoedeling. Dit het onlangs aan die lig gekom dat van hierdie chemise besoedelstowwe subtiel die endokriene sisteem versteur en so aanleiding gee tot gesondheidsprobleme in terme van die voortplantingsisteem en tiroied sisteem (groei en ontwikkeling) by diere en moontlik ook die mens. Daar is beperkte gebruik van biologiese toetse wat inligting verskaf oor sitotoksiteit, inflammatoriese aktiwiteit en endokriene versteuring. Die doel van hierdie studie was dus om van hierdie biologiese toetse, wat normaalweg nie deel uitmaak van die roetine munisipale (Stad van Kaapstad) opvangsgebied monitering nie, gebruik te maak. Die Eerste-, Kuilsrivier, Wes Kaap, onder beheer van Stad Kaapstad is gekies en alhoewel die opvangsgebied nie water bydra tot drinkwaterbronne nie, word die opvangsgebied beïnvloed deur verskeie mensgemaakte bronne van besoedeling (afloop vanuit omliggende lanbougebiede). Binne die kort tydsraamwerk van die projek (ses maande) is besluit om twee maande, Julie (volg ‘n droë somer en herfs seisoen) en Oktober (volg ‘n nat winter en vroeë lente seisoen) vir water kwaliteit monitering te kies. Ruimtelike variasie langs die loop van die opvangsgebied is ingesluit deur moniteringspunte (n=10), met in ag name van die potensiële besoedelingsbronne. Spesifieke doelwitte van die projek sluit in: Eerstens (Hoofstuk 2), om die in vitro biotoetse, laktaat hidrolise (LDH) vir sitotoksisiteit, proinflammatoriese hormoon Interleuikin-6 (IL-6) vir inflammatoriese aktiwiteit, vrygestel deur menslike bloedselle en ‘n Salmonella ELISA vir ontlasting besoedeling saam met bestaande chemise en biologiese (hoofsaaklik migrobiologiese) veranderlikes te gebruik. Die studie het getoon dat beduidende variasie in alle mikrobiologiese toetse asook IL-6 vrystelling en Salmonella voorkoms bestaan het tussen versamelpunte. Maandelikse variasie in sekere van die veranderlikes het ook voorgekom. Tweedens (Hoofstuk 3), is twee biotoetse wat die dooiervoorloperproteïen, vitellogeen (Vtg) as eindpunt gebruik geimplimenteer in a) ‘n in vitro Xenopus laevis lewersnit biotoets (vyf dag blootstelling) en b) ‘n in vivo Zebravis (Danio rerio) biotoets (sewe dag blootstelling) om estrogenisiteit in die Eerste-, Kuilsrivier opvangsgebied te evalueer. Alhoewel, die estrogeen behandelde positiewe kontrole water monsters Vtg produksie veroorsaak het in beide die in vitro lewer-kulture en in vivo vistoets, is geen dramatiess estrogeniese aktiwiteit by enige van die moniteringspunte gevind nie. Derdens (Hoofstuk 4), is ‘n biotoets wat die tiroïedbeheerde metamorfose in Xenopus laevis paddavisse gebruik om effekte op die tiroïedsisteem te evalueer. Die differensiële stimulering (versnelling), in vergelyking met ‘n negatiewe kontrole watermonster, van die tiroied sisteem is by twee moniteringspunte in die opvangsgebied waargeneem. Alhoewel die praktiese implementering van die paddavis semi-statiese (water word gereeld vervang) biotoets arbeidsintensief is, het alle bykomstige biotoetse waardevolle bykomstige inligting oor water kwaliteit verskaf wat ‘n belangrike bydrae tot ingeligte bestuursbesluite kan verleen. Dit is duidelik dat meer navorsing int verband met die menslike invloed langs die Eerste-, Kuilsrivier opvangsgebied nodig is, veral met maandlikse monitering vir seisoenale veranderinge.
Dromey, Jasmin Rachel. "Elucidating novel aspects of hypothalamic releasing hormone receptor regulation". University of Western Australia. School of Medicine and Pharmacology, 2008. http://theses.library.uwa.edu.au/adt-WU2008.0133.
Pełny tekst źródłaGomes, Ingrid Cristiane Pereira. "Avaliação endócrino-metabólica de pacientes com anemia falciforme: uma coorte de dez anos". Universidade Federal de Sergipe, 2016. https://ri.ufs.br/handle/riufs/3805.
Pełny tekst źródłaA anemia falciforme (AF), doença hereditária mais prevalente no mundo, apresenta, dentre diversas complicações, alterações endócrino-metabólicas, destacando-se retardo de crescimento e puberdade em crianças e adolescentes. A estatura final dos adultos com AF, entretanto, ainda é controversa e pouco estudada na literatura. Esta dissertação é composta por dois artigos originais. No primeiro artigo, “Crescimento e puberdade em uma coorte prospectiva de pacientes com anemia falciforme: avaliação em dez anos”, observou-se que os pacientes com AF apresentaram comprometimento de crescimento e atraso puberal quando comparados a controles saudáveis, todavia, ainda que tardiamente, atingiram maturação sexual normal. Além disso, alcançaram estatura normal na idade adulta, diferentemente do que ocorreu com peso e IMC, achado ainda mais evidente no sexo masculino. No segundo artigo, “Perfil endócrino-metabólico de adultos portadores de anemia falciforme”, observou-se que os homens com AF apresentaram maiores níveis de gonadotrofinas. Níveis das lipoproteínas de alta densidade (HDL) e baixa densidade (LDL) também foram menores no grupo AF. A elevada prevalência de HDL reduzido (96%) no grupo AF e sua correlação positiva com a concentração de hemoglobina e negativa com contagem de reticulócitos, contagem de leucócitos apontam para a possibilidade de o HDL poder se configurar um marcador que auxilie na predição de eventos clínicos adversos nesta população. Apesar de não ter havido diferença dos níveis de 25-hidroxivitamina entre os grupos, constatou-se maior prevalência de sua deficiência e insuficiência no grupo AF, o que potencializa o risco, já existente nesta população, de osteoporose. Os achados de ambos os estudos caracterizam os pacientes com AF em relação à evolução de seu crescimento e desenvolvimento até a fase adulta e mostram alterações endócrinometabólicas que merecem ser investigadas durante seu seguimento, a fim de prevenir outras complicações que possam comprometer sua qualidade de vida.
Costa, Fabiano Gonçalves. "Testículo de Astyanax altiparanae Garutti e Britski, 2000. Estudo morfológico, ultraestrutural e imuno-histoquímico". Universidade de São Paulo, 2011. http://www.teses.usp.br/teses/disponiveis/42/42134/tde-26012012-111709/.
Pełny tekst źródłaThe Astyanax altiparanae (Characiformes, Characidae), popularly known as lambari, is a fish that has ecologic and economic importance. Morphological studies on testis of South American teleost species are not frequently found in the appropriated literature. The aim of this work was to show the changes in the morphology of the testis of Astyanax altiparanae occurred through the gonadal cycle. It was found five stages of the gonadal cycle: regressed, early maturation, mid maturation, late maturation and regression. Ultrastructural study, reveals that secretory cells showed a great amount of organelles responsible for macromolecules synthesis, and lipids droplets. Immunohistochemical studies reveal details of the distribution of androgen receptor, claudin-1, actin, cytokeratin, type I collagen fibers, laminin and fibronectin in this organ. This work demonstrated that males of Astyanax altiparanae were able to develop the intersex, once oocytes were found in the testis of some individuals.
Ruchon, François. "Les manifestations endocriniennes au cours de la sarcoidose : a propos d'une observation". Lille 2, 1988. http://www.theses.fr/1988LIL2M190.
Pełny tekst źródłaLECOMTE, SYLVIE. "Les sequelles endocriniennes apres traitement des medulloblastomes de l'enfant : a propos de 14 observations". Lille 2, 1993. http://www.theses.fr/1993LIL2M152.
Pełny tekst źródłaTEISSIER, MARIE-PIERRE. "Les causes endocriniennes dans l'infertilite du couple : a propos de 121 cas". Limoges, 1989. http://www.theses.fr/1989LIMO0197.
Pełny tekst źródłaVercherat, Cécile. "Analyse structurale et fonctionnelle du gène MEN 1 de prédisposition à la Néoplasie Endocrinienne Multiple de type 1 (NEM 1)". Lyon 1, 2004. http://www.theses.fr/2004LYO10148.
Pełny tekst źródłaMagnus, Jeanne Marie Léonie. "Études cliniques des tumeurs adénoïdes". Paris : BIUM, 2003. http://www.bium.univ-paris5.fr/histmed/medica/cote?TPAR1895x360.
Pełny tekst źródłaFolia, Mireille. "Xéno-hormones et homéostasie buccale : impact sur les perceptions gustatives et les glandes salivaires". Phd thesis, Université de Bourgogne, 2012. http://tel.archives-ouvertes.fr/tel-00905906.
Pełny tekst źródłaFradet, Claire. "Anomalies biologiques rencontrées chez 85 patients hospitalisés pour anorexie mentale". Bordeaux 2, 1989. http://www.theses.fr/1989BOR25328.
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Pełny tekst źródłaSiah, Ahmed Pellerin Jocelyne Amiard Jean-Claude. "Rôle de la progestérone dans la maturation de Mya Arenaria et étude de l'effet d'un perturbateur endocrinien : le tributylétain (TBT) sur le niveau des hormones stéroïdiennes". [S.l.] : [s.n.], 2003. http://theses.univ-nantes.fr/thesemed/siahDOC03.pdf.
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