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Książki na temat „Effet de ligand”

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Data publikacji: 20 kwietnia 2024

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1

Parfenov, E. A. Biometals and ligands for anticancer drug design. Commack, N.Y: Nova Science Publishers, 1998.

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2

Chen, Ko-Ming. Effect of TLR2 ligands and IL-4 on Th2 cutaneous inflammation. [S.l: s.n.], 2013.

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3

K, Sen Amar, i Lee Tyrone, red. Receptors and ligands in psychiatry. Cambridge [England]: Cambridge University Press, 1988.

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4

M, Göthert, Molderings Gerhard J i Reis Donald J, red. Imidazoline receptors and their endogenous ligands: Current concepts and therapeutic potential. New York: New York Academy of Sciences, 1999.

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5

Hestermann, Eli V. Mechanisms of action for aryl hydrocarbon receptor ligands in the PLHC-1 cell line. Cambridge, Mass: Massachusetts Institute of Technology, 2000.

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6

service), SpringerLink (Online, red. Death receptors and cognate ligands in cancer. Heidelberg: Springer, 2009.

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7

J, Reis Donald, Bousquet Pascal, Parini Angelo i International Symposium on Imidazoline Receptors (2nd : 1994 : New York, N.Y.), red. The imidazoline receptor: Pharmacology, functions, ligands, and relevance to biology and medicine. New York: New York Academy of Sciences, 1995.

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8

Sutaria, Adil Dinyar. The effect of heterodentate chelatin P-N ligands on allyl and alkyl complexes of palladium and platinum. Salford: University of Salford, 1995.

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9

1944-, Hindmarch I., Ott H i Collegium Internationale Neuro-psychopharmacologicum Congress, red. Benzodiazepine receptor ligands, memory, and information processing: Psychometric, psychopharmacological, and clinical issues. Berlin: Springer-Verlag, 1988.

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10

E, Giesen-Crouse, red. Peripheral benzodiazepine receptors. London: Academic Press, 1993.

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11

Noncatalytic effect of the ubiquitin ligase Hul5 on proteasome function. 2009.

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12

Kalthoff, Holger. Death Receptors and Cognate Ligands in Cancer. Springer, 2012.

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13

Parfenov, E. A. Biometals And Ligands For Anticancer Drug Design: Molecular Mechanisms of Superoxide Dimutase Models Antitumor Effects. NOVA SCIENCE PUBLISHERS, 1998.

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14

Montgomery, Erwin B. Principles of Electrophysiology. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780190259600.003.0003.

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In many ways, post-operative DBS programming is “prescribing electricity” in much the same sense as “prescribing medications.” The principles of pharmacokinetics and pharmacodynamics that guide the rational use of medications find parallels in DBS. Many drugs have their effect by binding to ligand-gated channels, particularly channels that control the flow of electrical charges, in the form of ions across the cell membrane of the neuron in the soma. The binding of drugs to receptors can open the receptor to approximate the normal opening by endogenous neurotransmitters, or to block the channel from opening when endogenous neurotransmitters are released. In the case of DBS, the electrical charges manipulated in the nervous system similarly affect neuronal membrane channels; however, these initially and primarily are voltage gated ionic conductance channels, which are described in detail in this chapter.

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15

(Editor), M. Gothert, Gerhard J. Molderings (Editor) i Donald J. Reis (Editor), red. Imidazoline Receptors and Their Endogenous Ligands: Current Concepts and Therapeutic Potential (Annals of the New York Academy of Sciences). New York Academy of Sciences, 1999.

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16

Imidazoline Receptors and Their Endogenous Ligands: Current Concepts and Therapeutic Potential (Annals of the New York Academy of Sciences, V. 881). New York Academy of Sciences, 1999.

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17

The Imidazoline Receptor: Pharmacology, Functions, Ligands, and Relevance to Biology and Medicine (Annals of the New York Academy of Sciences, V. 763). New York Academy of Sciences, 1995.

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18

Lambert, David G. Mechanisms and determinants of anaesthetic drug action. Redaktor Michel M. R. F. Struys. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0013.

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This chapter is broken into two main sections: a general description of the principles of ligand receptor interaction and a discussion of the main groups of ‘targets’; and explanation of some common pharmacological interactions in anaesthesia, critical care, and pain management. Agonists bind to and activate receptors while antagonists bind to receptors and block the effects of agonists. Antagonists can be competitive (most common) or non-competitive/irreversible. The main classes of drug target are enzymes, carriers, ion channels, and receptors with examples of anaesthetic relevance interacting with all classes. There are many examples in anaesthesia where multiple interacting drugs are co-administered—polypharmacology. To give an example: neuromuscular blockade. Rocuronium is a non-depolarizing neuromuscular blocker acting as a competitive antagonist at the nicotinic acetylcholine receptor. Rocuronium competes with endogenous acetylcholine to shift the concentration–response curve for contraction to the right. The degree of contractility is less for a given concentration of acetylcholine (agonist) in the presence of rocuronium. Using the same principle, the rightward shift can be compensated by increasing the amount of acetylcholine (as long as the amount of rocuronium presented to the receptor as an antagonist remains unchanged, its action can be overcome by increased agonist). Acetylcholine at the effect site is increased by acetylcholinesterase inhibition with neostigmine. One of the side-effects of neostigmine is that it acts as an indirect parasympathomimetic. In the cardiovascular system this would lead to muscarinic receptor-mediated bradycardia; these effects are routinely reversed by the competitive muscarinic antagonist glycopyrrolate.

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19

Bonnet, Francis, Marc E. Gentili i Christophe Aveline. Post-surgical analgesia and acute pain management. Redaktor Jonathan G. Hardman. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199642045.003.0046.

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Postoperative and acute pain remains uncontrolled in many instances, leading to the risk of development of chronic pain syndromes. After tissue damage, activation of postsynaptic NMDA receptors, also induced by opioid administration, plays a key role in postoperative pain sensitization, allodynia, and hyperalgesia. Pain intensity may depend on sex, age, anxiety, and genetic factors but in clinical practice, surgical procedure is the main determinant of pain, although pain may vary from one patient to one another. Serial pain measurements are mandatory to assess pain intensity and to guide pain treatment. They are based on unidimensional simple pain scales. Multimodal analgesia combining opioid and non-opioid agent and regional block or infiltration is the rule postoperatively, although evidence is sometimes lacking to support all the combinations commonly used. Opioids should be used on demand while other agents are administered systematically. Non-steroidal anti-inflammatory drugs decrease opioid demand as well as paracetamol although to a less extend. Antihyperalgesic agents including NMDA blockers (ketamine) and α‎2-δ‎ ligands (gabapentin, pregabalin) have an opioid-sparing effect and may prevent the occurrence of chronic pain syndrome after surgery. Regional blocks and infiltration provide good quality analgesia but the balance between advantages and drawbacks of central block need to be evaluated carefully for each surgical procedure.

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20

Journalism and Digital Labor. Taylor & Francis Group, 2020.

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21

Neilson, Tai. Journalism and Digital Labor: Experiences of Online News Production. Routledge, Chapman & Hall, Incorporated, 2022.

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22

Neilson, Tai. Journalism and Digital Labor: Experiences of Online News Production. Taylor & Francis Group, 2020.

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23

Neilson, Tai. Journalism and Digital Labor: Experiences of Online News Production. Taylor & Francis Group, 2020.

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24

High-Chromium Ferritic and Martensitic Steels for Nuclear Applications (Monograph (American Society for Testing and Materials), 3.). ASTM International, 2001.

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25

Mcennis, Scott. Disrupting Sports Journalism. Taylor & Francis Group, 2021.

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26

Disrupting Sports Journalism. Taylor & Francis Group, 2021.

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27

High-Resolution NMR Techniques in Organic Chemistry. Elsevier Science, 2016.

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28

Metro Dailies in the Age of Multimedia Journalism. Temple University Press, 2020.

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29

Metro Dailies in the Age of Multimedia Journalism. Temple University Press, 2020.

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30

World without Fish. Workman, 2011.

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