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Abbassi, Ramzi Hussam Suleiman. "Targeting glioblastoma with microtubule-targeting agents and epigenetic modulators". Thesis, The University of Sydney, 2020. https://hdl.handle.net/2123/25072.
Pełny tekst źródłaWright, J. J. "Targeting of colloidal drug carriers". Thesis, University of Nottingham, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381059.
Pełny tekst źródłaSaunders, J. E. "Drug targeting using albumin microspheres". Thesis, University of Nottingham, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.381061.
Pełny tekst źródłaORSATO, ALEXANDRE. "Studies on tumor drug targeting". Doctoral thesis, Università degli Studi di Milano-Bicocca, 2011. http://hdl.handle.net/10281/19200.
Pełny tekst źródłaNacev, Aleksandar Nelson. "Magnetic drug targeting| Developing the basics". Thesis, University of Maryland, College Park, 2013. http://pqdtopen.proquest.com/#viewpdf?dispub=3587279.
Pełny tekst źródłaFocusing medicine to disease locations is a needed ability to treat a variety of pathologies. During chemotherapy, for example, typically less than 0.1% of the drugs are taken up by tumor cells, with the remaining 99.9% going into healthy tissue. Physicians often select the dosage by how much a patient can physically withstand rather than by how much is needed to kill all the tumor cells. The ability to actively position medicine, to physically direct and focus it to specific locations in the body, would allow better treatment of not only cancer but many other diseases.
Magnetic drug targeting (MDT) harnesses therapeutics attached to magnetizable particles, directing them to disease locations using magnetic fields. Particles injected into the vasculature will circulate throughout the body as the applied magnetic field is used to attempt confinement at target locations. The goal is to use the reservoir of particles in the general circulation and target a specific location by pulling the nanoparticles using magnetic forces.
This dissertation adds three main advancements to development of magnetic drug targeting. Chapter 2 develops a comprehensive ferrofluid transport model within any blood vessel and surrounding tissue under an applied magnetic field. Chapter 3 creates a ferrofluid mobility model to predict ferrofluid and drug concentrations within physiologically relevant tissue architectures established from human autopsy samples. Chapter 4 optimizes the applied magnetic fields within the particle mobility models to predict the best treatment scenarios for two classes of chemotherapies for treating future patients with hepatic metastatic breast cancer microtumors.
Macadam, Anglea Brenda. "Drug targeting in the gastrointestinal tract". Thesis, University of Brighton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.306400.
Pełny tekst źródłaHyde, Robert. "Drug targeting with phagocytic polymorphonuclear leucocytes". Thesis, Aston University, 1989. http://publications.aston.ac.uk/12577/.
Pełny tekst źródłaZhang, Qian. "Natural Product Drug Discovery Targeting Cancer". Thesis, Griffith University, 2017. http://hdl.handle.net/10072/370435.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Natural Sciences
Science, Environment, Engineering and Technology
Full Text
Govender, Thirumala. "Enhancing drug incorporation into nanoparticulate systems". Thesis, University of Nottingham, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299551.
Pełny tekst źródłaVance, Nicholas Robert. "Targeting dynamic enzymes for drug discovery efforts". Diss., University of Iowa, 2018. https://ir.uiowa.edu/etd/6517.
Pełny tekst źródłaCORRIAS, FRANCESCO. "Nanocarriers for drug targeting and improved bioavailability". Doctoral thesis, Università degli Studi di Cagliari, 2014. http://hdl.handle.net/11584/266439.
Pełny tekst źródłaRedhead, Helen Margaret. "Drug loading of biodegradable nanoparticles for site specific drug delivery". Thesis, University of Nottingham, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338495.
Pełny tekst źródłaDunn, Susan Elizabeth. "Biodegradable nanosphere systems for drug targeting : with emphasis on systems for bone marrow targeting". Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.294260.
Pełny tekst źródłaWard, Richard. "Targeting inositol monophosphatase in structure-based drug design". Thesis, University of Birmingham, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.289291.
Pełny tekst źródłaMoshiri, Houtan. "Targeting the editosome - from drug discovery to function". Thesis, McGill University, 2013. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=117029.
Pełny tekst źródłaPathogènes des trypanosomatides sont responsable de maladies dévastatrices chez les humains et les animaux et continuent de poser un défi majeur dans le développement de médicaments. L'expression du gène mitochondrial chez les agents pathogènes de la famille des trypanosomatides nécessite une modification post transcriptionnelle vaste, connue sous le nom d'édition de l'ARN, qui génère des transcrits traduisibles pour les composants essentiels du complexe respiratoire du parasite. L'édition de l'ARN est catalysée par un complexe multiprotéique appelé éditosome, dont la plupart des protéines sont essentiels pour la survie du parasite, ce qui fait de l'éditosome une cible appropriée pour la découverte de médicaments. Cependant, la façon dont les protéines de l'éditosome sont assemblés et effectue l'édition de l'ARN n'est pas entièrement comprise. Nous émettons l'hypothèse que l'identification de nouveaux composés ciblant et perturbant ce processus unique permettra non seulement de déterminer la fonction et l'assemblage des protéines de l'éditosome mais également d'être utilisé en tant que composés contre les trois principaux pathogènes de la famille des trypanosomatides. Dans la première partie de la thèse, je présente l'élaboration et l'essai basé sur la fluorescence avec un criblage à haut débit pour l'identification de composés qui inhibent la fonction de l'éditosome. En outre, nous avons utilisé notre test pour confirmer l'effet inhibiteur des inhibiteurs connus d'une protéine essentielle de l'éditosome, T. brucei RNA editing ligase 1(TbREL1). Grâce à notre test, nous avons montré également que ces inhibiteurs sont capables d'inhiber la fonction d'édition de l'ARN dans le contexte de l'éditosome partiellement purifié. La deuxième partie de la thèse décrit un essai pilote d'un petit ensemble de composés qui ont été identifiés par criblage virtuel contre TbREL1. En utilisant des tests secondaires, nous avons confirmé la spécificité de l'inhibition et montré que ces composés ont trouvé d'autres cibles en plus de celle de TbREL1. Nous avons montré pour la première fois que les composés inhibiteurs interférent avec l'interaction de l'éditosome à l'ARN substrat et par conséquent entraîne la perte de toutes les activités liées à la fonction de l'éditosome. De plus, nous avons montré que cette inhibition est capable d'interférer avec l'assemblage des protéines de l'éditosome et avons proposé un modèle pour décrire le mécanisme possible d'inhibition par ces composés. Dans la troisième partie de la thèse, je présente une étude qui compare le mécanisme d'action des composés inhibiteurs dans le contexte de TbREL1 recombinant ou natif dans l'éditosome. Nous avons montré que ces composés interfèrent avec les activités de liaison à l'ARN des facteurs accessoires de l'éditosome MRP1 et MRP2 (protéines liant les ARN mitochondriaux 1 & 2) qui aboutissent à la perturbation d'autres activités d'édition. Nous avons montré que ces composés peuvent seulement inhiber la fonction de TbREL1 en l'absence des facteurs accessoires. En outre, nous avons effectué une mutagenèse d'alanine des résidus d'acides aminés de TbREL1 qui sont prévus dans la liaison aux inhibiteurs. Nous fournissons une carte détaillée de la structure du complexe enzyme-inhibiteur avec une opportunité de conception future de plus puissants inhibiteurs de TbREL1. Ces études ont conduit à l'identification et la caractérisation de nouveaux inhibiteurs qui se traduisent par l'inactivation de la fonction de l'éditosome. En outre, l'élucidation du mécanisme d'inhibition de l'édition de l'ARN fournit une base pour la sélection future d'inhibiteurs plus efficaces et plus puissants contre les protéines de l'éditosome. Par conséquent, ce travail contribue à la fois aux études fonctionnelles d'un mécanisme d'expression d'un gène essentiel et à une possibilité passionnante pour le développement de futur médicament contre trois agents pathogènes liés de la famille des trypanosomatides.
Porter, Christopher John Hamilton. "Targeting collodial drug carriers to the bone marrow". Thesis, University of Nottingham, 1992. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.315061.
Pełny tekst źródłaChung, Terence. "Staphylococcus aureus DNA gyrase : mechanism and drug targeting". Thesis, University of East Anglia, 2012. https://ueaeprints.uea.ac.uk/54338/.
Pełny tekst źródłaAl-Shammaa, Zaid. "Targeting Drug-Resistant Tuberculosis Using SMART Nanotechnology Approach". University of Cincinnati / OhioLINK, 2015. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1439310613.
Pełny tekst źródłaSieg, Jacob P. "Spectroscopic methods for drug-discovery targeting RNA thermometers". Ohio University Honors Tutorial College / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ouhonors1492763707328646.
Pełny tekst źródłaZhang, Liang. "Strategies for local drug delivery targeting the oesophagus". Thesis, Aston University, 2008. http://publications.aston.ac.uk/15410/.
Pełny tekst źródłaBARDELLI, DONATELLA. "SHWACHMAN-DIAMOND SYNDROME: FROM PATHOGENESIS TO DRUG TARGETING". Doctoral thesis, Università degli Studi di Milano-Bicocca, 2017. http://hdl.handle.net/10281/170787.
Pełny tekst źródłaShwachman-Diamond Syndrome (SDS) is a rare autosomal recessive disease, characterized by exocrine pancreatic disorder, hematological aberrancies, bone marrow failure and cognitive impairment. In 90% of patients the SBDS gene is found mutated. Similar to other marrow failure syndromes, SDS patients have an increased risk for developing myelodysplastic syndrome and AML. To date, the mechanisms underlying the bone marrow failure in SDS patients are not fully understood. Microenvironment constituents and in particular mesenchymal stromal cells (MSCs) are considered the pivotal organizers for the generation, maintenance and plasticity of the hematopoietic stem cell niche. Recent studies show that specific changes in MSCs may be sufficient to initiate a complex phenotype of disordered homeostasis with similarities to myelodysplasia. We have demonstrated that MSCs obtained from SDS patients were comparable in vitro to HD but gene expression analysis of 16 SDS-MSCs showed that these cells had a specific gene expression signature compared to HD. These results suggest that it is possible that MSCs could be involved in the pathogenesis of the SDS marrow disorders. We increased our patients cohort and investigated whether SDS-MSCs were able to sustain malignant evolution using an innovative scaffold-free in vivo system based on the ex vivo generation of semi-cartilaginous pellets (SCPs) from human MSCs. We obtained SCPs stimulating MSCs for 21 days with a specific differentiating medium and a complete and correct formation of cartilaginous tissues both in HD and SDS samples. These SCPs were transplanted heterotopically into subcutaneous tissue of immunocompromised mice. After 60 days, we sacrificed mice and collected ossicles. We found that in 90% of cases, HD were able to recreate the hematopoietic microenvironment, with the establishment of a complete marrow niche, while none of the transplanted SDS-SCPs was able to recreate the hematopoietic microenvironment, revealing a defect in these differentiating process. The second part of our study was focused on testing a specific drug able to act on nonsense stop codon mutation, one of the most diffuse alterations in SDS patients, linked to risk of developing myelodysplastic syndrome. We successfully obtained restoration of SBDS protein in different cell lineages deriving from patients (Lymphoblastoids, MSCs, mononuclear cells from bone marrow). Protein restoration was also accompanied in some cases with an improvement of functionality. In particular, mononuclear cells from bone marrow treated with drug showed an increase in their ability to form colonies when cultured in a specific assay. This represents a powerful result, due to the potential clinical consequences related to possible therapeutic strategy. Indeed, SDS patients in future could take advantage of this drug to ameliorate their hematological defects and abolish other symptoms.
Kim, Gloria J. "Cancer nanotechnology engineering multifunctional nanostructures for targeting tumor cells and vasculatures /". Diss., Atlanta, Ga. : Georgia Institute of Technology, 2007. http://hdl.handle.net/1853/22610.
Pełny tekst źródłaCommittee Chair: Nie, Shuming; Committee Member: Lyon, L. Andrew; Committee Member: McIntire, Larry V.; Committee Member: Murthy, Niren; Committee Member: Prausnitz, Mark R.
Baumann, Romy [Verfasser]. "Ferrofluid-Aerosole als Drug Carrier für das inhalative magnetische Drug Targeting / Romy Baumann". Greifswald : Universitätsbibliothek Greifswald, 2011. http://d-nb.info/1017185212/34.
Pełny tekst źródła兰林林. "细胞特异性核酸适配体介导的靶向葯物传输系统及其在疾病诊断与治疗中的应用". HKBU Institutional Repository, 2013. http://repository.hkbu.edu.hk/etd_ra/1366.
Pełny tekst źródłaKoosha, Fariba. "Preparation and characterisation of biodegradable polymeric drug carriers". Thesis, University of Nottingham, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329839.
Pełny tekst źródłaZephyr, Jacqueto. "Robust Drug Design Strategies and Discovery Targeting Viral Proteases". eScholarship@UMMS, 2021. https://escholarship.umassmed.edu/gsbs_diss/1157.
Pełny tekst źródłaYap, Damian Boon Siew. "Investigating how the apoptopic pathways of E2F1 and p53 may be inhibited". Thesis, Imperial College London, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.246744.
Pełny tekst źródłaNorman, Maria Elizabeth. "The adsorption of proteins to colloidal carriers". Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.280291.
Pełny tekst źródłaMorgan, Peter John. "Hydrodynamic properties of polyisoprene/polyoxyethylene block copolymers". Thesis, University of Nottingham, 1991. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.293600.
Pełny tekst źródłaSenior, Judith Helen. "Liposomes in drug delivery : site-directed approaches using active and passive targeting". Thesis, University College London (University of London), 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.261677.
Pełny tekst źródłaStevens, Phillip James. "An approach to drug formulation and targeting liposomes and lipid nanoparticles for folate receptor targeting". Connect to this title online, 2005. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=osu1111092653.
Pełny tekst źródłaTitle from first page of PDF file. Document formatted into pages; contains xvi, 110 p.; also includes graphics (some col.) Includes bibliographical references (p. 98-110). Available online via OhioLINK's ETD Center
Tabata, Yasuhiko. "Drug targeting through polymer conjugation based on metal coordination". 京都大学 (Kyoto University), 2003. http://hdl.handle.net/2433/148611.
Pełny tekst źródłaMarouf, W. M. Y. "Design and characterisation of targeting drug-loaded polymeric nanoparticles". Thesis, Queen's University Belfast, 2008. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.484986.
Pełny tekst źródłaWamsley, Andrea Kay. "Poly(amino acid) as a targeting drug delivery carrier". Scholarly Commons, 2002. https://scholarlycommons.pacific.edu/uop_etds/2726.
Pełny tekst źródłaMuttha, Dharmendra Kumar. "Spray dried drug delivery systems for ileo-colonic targeting". Thesis, Kingston University, 2014. http://eprints.kingston.ac.uk/29882/.
Pełny tekst źródłaMa, Leyuan. "Targeting Drug Resistance in Chronic Myeloid Leukemia: A Dissertation". eScholarship@UMMS, 2016. https://escholarship.umassmed.edu/gsbs_diss/870.
Pełny tekst źródłaBenzine, Youcef. "Enzymatically triggered polymeric drug delivery systems for colon targeting". Thesis, Lille 2, 2019. http://www.theses.fr/2019LIL2S036.
Pełny tekst źródłaChronic inflammatory bowel diseases (IBD) today affects close to 200,000 people in France. They are characterized by the inflammation of the wall of a part of the digestive tract. They usually include Ulcerative Colitis and Crohn’s disease. Both are chronic diseases that involve inflammation of the colonic mucosa. The main difference between Crohn’s disease and Ulcerative Colitis is the location and nature of inflammation. Crohn’s disease can affect any part of the GIT from mouth to anus but in most cases attacks the terminal ileum. In contrast, Ulcerative Colitis is restricted to the colon and the rectum. An ideal dosage form should effectively protect the drug in the stomach and small intestine and subsequently release the drug in the colon in a targeted and controlled manner. The objective of this work was to develop new drug delivery systems containing a polysaccharide (pectin, guar gum, inulin ...), which are degradable by the colonic bacteria and a hydrophobic thermoplastic polymer (ethylcellulose, polyurethane, polyvinyl acetate ...), which will reduce the hydrophilicity of the polysaccharide. The technique used for the preparation of these dosage forms is hot-melt extrusion. It is a continuous and free solvent process that allows the manufacturing of a dosage form called "extrudate" by forcing the soften material through an orifice. It has been demonstrated that extrudates based on polyvinyl acetate/polyurethane and inulin can minimize the release of a model active substance in the upper part of GIT due to the hydrophobic properties of polyvinyl acetate. Indeed, these extrudates uptake low amount of water and lose low dry mass upon exposure to media simulating the stomach and the small intestine. However, once in contact with the colonic flora, these systems show a considerable loss of mass due to the degradation of inulin by enzymes secreted by colonic bacteria. In another study, hot melt extrudates based on ethylcellulose blended with different types of polysaccharides (guar gum, inulin, corn starch, maltodextrin, pectin and chitosan) were studied for the development of controlled drug delivery systems. Anhydrous theophylline and diprophylline have been used as model drugs. This study was useful to set the extrusion parameters: temperature 100 °C; screw speed 30 rpm; feed rate 3 cc/min; 30 % dibutyl sebacate as a plasticizer. Importantly, hot melt extrudates based on ethylcellulose:guar gum blends offer an interesting potential as controlled drug delivery systems: They can be prepared at temperatures of about 100 °C, provide broad spectra of drug release patterns (in particular about constant drug release rates). Finally, hot melt extrudates remained stable after 1 year storage at ambient conditions
Ma, Leyuan. "Targeting Drug Resistance in Chronic Myeloid Leukemia: A Dissertation". eScholarship@UMMS, 2011. http://escholarship.umassmed.edu/gsbs_diss/870.
Pełny tekst źródłaKarrout, Youness [Verfasser]. "Innovative drug delivery systems for colon targeting / Youness Karrout". Berlin : Freie Universität Berlin, 2008. http://d-nb.info/1027497586/34.
Pełny tekst źródłaWang, Feng. "Structure-based drug mechanism study and inhibitor design targeting tuberculosis". [College Station, Tex. : Texas A&M University, 2007. http://hdl.handle.net/1969.1/ETD-TAMU-1439.
Pełny tekst źródłaWong, Ka Yeung Mark. "Drug clearance mechanisms and chemotherapy response". Thesis, The University of Sydney, 2007. https://hdl.handle.net/2123/28094.
Pełny tekst źródłaMalek, Kotiba. "Redox-Active Silver N-Heterocyclic Carbene Complexes: A Dual Targeting Antibacterial Drug". Wright State University / OhioLINK, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=wright1535290903921698.
Pełny tekst źródłaKok, Robbert Jan. "Targeting of captopril to the kidney: towards selective renal ACE inhibition". [S.l. : [Groningen : s.n.] ; University of Groningen] [Host], 2008. http://irs.ub.rug.nl/ppn/.
Pełny tekst źródłaQuader, Sabina, i N/A. "Selective Synthetic Modification of Aminoglycosides for Drug Targeting to Tuberculosis". Griffith University. School of Biomolecular and Physical Sciences, 2007. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20071024.151619.
Pełny tekst źródłaArmstrong, Trevor Ian. "Protein adsorption onto polymeric nanoparticles : its relevance to drug targeting". Thesis, University of Nottingham, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.284047.
Pełny tekst źródłaSaraf, Poonam S. "RGD based peptide amphiphiles as drug carriers for cancer targeting". Scholarly Commons, 2014. https://scholarlycommons.pacific.edu/uop_etds/137.
Pełny tekst źródłaQuader, Sabina. "Selective Synthetic Modification of Aminoglycosides for Drug Targeting to Tuberculosis". Thesis, Griffith University, 2007. http://hdl.handle.net/10072/367086.
Pełny tekst źródłaThesis (PhD Doctorate)
Doctor of Philosophy (PhD)
School of Biomolecular and Physical Sciences
Faculty of Science, Environment, Engineering and Technology
Full Text
PERIN, ELENA. "Passive drug targeting and delivery of antitumor Pt(IV) prodrugs". Doctoral thesis, Università del Piemonte Orientale, 2017. http://hdl.handle.net/11579/86923.
Pełny tekst źródłaStrich, Samuel. "Oral drug delivery systems based on polysaccharides for colon targeting". Electronic Thesis or Diss., Université de Lille (2022-....), 2023. http://www.theses.fr/2023ULILS081.
Pełny tekst źródła10 million people worldwide, over 1.5 million in North America and 2 million in Europe. Those are the numbers of people affected by inflammatory bowel disease (IBD) in each region quoted, respectively. Including both Crohn's disease (CD) and ulcerative colitis (UC), inflammatory bowel disease has emerged as a public health challenge worldwide in the past decades. Often diagnosed between 15 and 35 years old, IBD are characterized by moderate to severe symptoms, and have in common relapsing-remitting cycles of mucosal inflammation.To date, there is no cure for IBD. Defined as colon targeting, targeted drug delivery systems is a way to get selective and efficient delivery of pharmacologically active compounds to the predetermined targeted region in therapeutic concentrations along with minimizing side effects of the drug. Current strategies for colon targeting rely on : *) prodrugs, **) pH-dependant systems, ***) time-dependant systems, ****) microbially triggered systems.Of all approaches, microbiota sensitive systems are currently known as the best ones for colonic drug delivery. It is also possible to combine several complementary approaches (pH- and microbiota sensitive) to significantely favor localized drug release.Our project aimed to develop 5 mm mini-tablets for colon targeting. First, a comparison of different film coatings was made to highlight the most interesting drug release profiles. Then, an innovative formulation, combining synthetic and natural polymers as well as polysaccharides, was evaluated. Different blend ratios were selected as well for films as for coated mini-tablets. In vitro drug release was carried out in simulated digestive fluids for a 32 h duration, including:- 0.1 N HCl or simulated gastric fluid (2 h)- PBS 6.8 or simulated intestinal fluid (6 h)- Colonic simulated medium with and without patients' faeces (24 h).Colonic simulated medium inoculated with patients' faeces allowed for working closer to pathophysiological conditions. Relevant results were obtained and paved the way for a promising monolayer technology. None or negligible drug release occurred up to 8 h, in the upper GIT. Also, drug could be totally protected in the lower gastrointestinal tract.Ethylcellulose, as a thermoplastic polymer, prevented from premature dissolution.Shellac, as a natural resin, provided pH-dependant properties.The adjunction of a polysaccharide acted as a substrate of microbiota.Interestingly, colonic release profiles could be optimized depending on the amount of polysaccharide added into the system
Drieman, Johannes Cornelis. "Drug targeting to the kidney N-acetyl-L-[gamma]-glutamyl derivatives as kidney-selective prodrugs /". Maastricht : Maastricht : Datawyse ; University Library, Maastricht University [Host], 1989. http://arno.unimaas.nl/show.cgi?fid=6187.
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