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Artykuły w czasopismach na temat „Drug physico-chemical compatibility”

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Data publikacji: 14 września 2024

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1

Sharma, N., and T. Sinderpal. "Sterculia Gum: Chemical Structure, Composition and Physico-Chemical Properties." Asian Journal of Chemistry 32, no. 1 (2019): 1–8. http://dx.doi.org/10.14233/ajchem.2020.22283.

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Physico-chemical properties are crucial characteristics of hydrocolloids as they decide the applicability of them. Rheology of system, flow behaviour and mechanical properties make hydrocolloids suitable for food industry. Modification of consistency or texture properties of functional polymers also controls their sensory characteristics, thereby they become significant essences such as thickener, gelling agents, foaming agent, texture modifier, viscosifier, emulsifier, stabilizer and binder. Industrial and pharmaceutical applications are also controlled by some suitable physico-chemical prope
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Sharma, Shyam Bihari, Suman Jain, and K. Ganesan. "Preformulation Studies of Pralidoxime Chloride for Formulation Development of Microspheres." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 338–42. http://dx.doi.org/10.22270/jddt.v9i4-s.3336.

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Microspheres are one of the novel drug delivery system which possess several applications and are made up of assorted polymers. Microspheres can be defined as solid, approximately spherical particles ranging in size from 1 to 1000 μm range in diameter having a core of drug and entirely outer layers of polymers as coating material. They are made up of polymeric, waxy or other protective materials i.e. biodegradable synthetic polymer and modified natural products such as starches, gums, proteins, fats and waxes. Preformulation is a group of studies that focus on the physicochemical properties of
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Tiwari, Sandip Prasad, and Gali Vidyasagar. "Identification, Characterization and Drug-Excipient Compatibility of Diltiazem Hydrochloride by Physico-Chemical Techniques." UK Journal of Pharmaceutical Biosciences 2, no. 5 (2014): 49. http://dx.doi.org/10.20510/ukjpb/2/i5/91134.

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Bruni, Giovanna, Vittorio Berbenni, Chiara Milanese, Alessandro Girella, and Amedeo Marini. "Drug-excipient compatibility studies in binary and ternary mixtures by physico-chemical techniques." Journal of Thermal Analysis and Calorimetry 102, no. 1 (2009): 193–201. http://dx.doi.org/10.1007/s10973-009-0382-z.

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Vivekanandan S, Raghunandan Reddy K, and Venkatesan P. "Preformulation characterization towards design and development of dexibuprofen loaded nanoparticles." International Journal of Research in Pharmaceutical Sciences 11, no. 4 (2020): 8138–45. http://dx.doi.org/10.26452/ijrps.v11i4.4892.

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The intention of the current study was to investigate the Physico-chemical characteristics of Dexibuprofen loaded nanoparticles. Dexibuprofen is an NSAID - non-steroidal anti-inflammatory drug intended for the treatment of rheumatoid arthritis related symptoms. In current market trends, the tablets and capsule dosage forms captures major market contribution. A systematic evaluation of physico chemical characteristics of the drug powder, it’s characteristics was performed as a basic step at the start of formulation development of the dosage form. The formulation development approach is decided
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Mohamed, Amir Ibrahim, Amal Abd-Elaal El-Khamery, Mohamed Ismail Herry, and Alaa Ibrahim Mohamed. "Compatibility Determination of Drug-Polymer, Drug-Excipient & Drug-Intravenous Admixtures Using Chemometric-assisted UVspectrophotometry." Current Pharmaceutical Analysis 16, no. 2 (2020): 125–42. http://dx.doi.org/10.2174/1573412914666181011142351.

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Purpose: A new multivariate chemometric approach was developed for fast and economic compatibility determinations of ranitidine hydrochloride (as model drug) with certain pharmaceutical; polymers (Alginate & Chitosan), excipient (Lactose) and intravenous fluids (Dextrose, Ringer & Dextrose/ Ringer). Binary mixtures of the drug and each item were prepared and investigated by chemometric- assisted UV- spectrophotometry as well as by HPLC reference method. Methods: Five drug concentration levels (0.004-0.025mg/ml) of test-mixtures were used and the average drug recovery percent after two
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Yadav, RK, Satyam Prakash, K. Yadav, NK Yadav, and M. Mostafa. "Physico-chemical evaluation of Gastroretentive Ranitidine Hydrochloride: An Anti-Ulcer Drug." Janaki Medical College Journal of Medical Science 3, no. 2 (2016): 4–12. http://dx.doi.org/10.3126/jmcjms.v3i2.16075.

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Background and Objectives: The prevention and treatment of peptic ulcers has become an important challenge in the current medicine world. Modern progress in novel drug delivery system aims to improve the efficacy of the drug molecule by formulating a dosage form of RHCL. One of the most feasible approaches for achieving a prolonged and predictable drug delivery profile in GI tract is to control the gastric residence time. Therefore, a multi-unit gastro retentive dosage form of RHCL capable of floating on simulated gastric fluid for more than 12 hours was formulated and evaluated.Materials and
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Kamin, Wolfgang, Astrid Schwabe, and Irene Krämer. "Inhalation solutions – which one are allowed to be mixed? Physico-chemical compatibility of drug solutions in nebulizers." Journal of Cystic Fibrosis 5, no. 4 (2006): 205–13. http://dx.doi.org/10.1016/j.jcf.2006.03.007.

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Kamin, Wolfgang, Frank Erdnüss, and Irene Krämer. "Inhalation solutions — Which ones may be mixed? Physico-chemical compatibility of drug solutions in nebulizers — Update 2013." Journal of Cystic Fibrosis 13, no. 3 (2014): 243–50. http://dx.doi.org/10.1016/j.jcf.2013.09.006.

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10

Ronowicz-Pilarczyk, Joanna. "Compatibility Study of Ketoprofen With Selected Excipients Used in Solid Dosage Forms: Experimental Design Approach." Acta Poloniae Pharmaceutica - Drug Research 80, no. 5 (2023): 717–22. http://dx.doi.org/10.32383/appdr/172622.

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A good understanding of the physico-chemical characteristics of a drug substance and excipients is necessary to obtain a safe and effective drug dosage form. Based on the current recommendations of the regulatory agencies (EMA, FDA) regarding the implementation of the Quality by Design concept at the drug product development stage, this article is focused on the application of the experimental design approach at the preformulation studies. The purpose of this work was the implementation of experimental design methodology in a compatibility study between ketoprofen (non-steroidal anti-inflammat
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11

Dr. P Perumal. "The Preparation and In-vitro Evaluation of Sustained Release Capsules of Rivastigmine Tartrate." Asian Journal of Medicine and Biomedicine 7, no. 2 (2023): 139–65. http://dx.doi.org/10.37231/ajmb.2023.7.2.624.

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Rivastigmine tartrate is a cholinesterase inhibitor, used in the treatment of dementia associated with Parkinson’s disease and it is currently available in a capsule form. Hydroxy Propyl Methyl Cellulose (HPMC) is the most important hydrophilic carrier material used for the preparation of oral controlled drug delivery systems due to its high swellability and its significant effect on the release kinetics of an incorporated drug. The present study was designed to prepare sustained release granules of Rivastigmine tartrate by using HPMC as matrix former, Microcrystalline cellulose (MCC) as dilue
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Amin, Prakruti, and Manish Patel. "Preformulation Studies of Varenicline for Formulation and Development of a Novel Orally Disintegrating Film." Journal of Pharmaceutical Research International 35, no. 17 (2023): 31–40. http://dx.doi.org/10.9734/jpri/2023/v35i177388.

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Objective: The major goal of pre-formulation research is to create a drug delivery system that is stable, elegant, safe, and effective by determining the drug's kinetic profile, the formulation's compatibility with various excipients, and the physico-chemical characteristics of new drug molecules. This could offer crucial support for executing formulation design or the need for the molecular change. Therefore, in the current study, studies on Varenicline (VAR)'s appropriateness for oral formulation were conducted. Similar to cytisine, VAR functions as a partial nicotine receptor agonist. It bl
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13

Qushawy, Mona. "Effect of the Surfactant and Liquid Lipid Type in the Physico-chemical Characteristics of Beeswax-based Nanostructured Lipid Carrier (NLC) of Metformin." Pharmaceutical Nanotechnology 9, no. 3 (2021): 200–209. http://dx.doi.org/10.2174/2211738509666210222143716.

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Background: Metformin (MF) is an antidiabetic drug that belongs to class III of the biopharmaceutical classification system (BCS) characterized by high solubility and low permeability. Objective: The study aimed to prepare metformin as nanostructured lipid carriers (MF-NLCs) to control the drug release and enhance its permeability through the biological membrane. Methods: 22 full factorial design was used to make the design of MF-NLCs formulations. MFNLCs were prepared by hot-melt homogenization-ultra sonication technique using beeswax as solid lipid in the presence of liquid lipid (either cap
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14

Saleem, Anam, Naveed Akhtar, Muhammad Usman Minhas, Arshad Mahmood, Kifayat Ullah Khan, and Orva Abdullah. "Highly Responsive Chitosan-Co-Poly (MAA) Nanomatrices through Cross-Linking Polymerization for Solubility Improvement." Gels 8, no. 3 (2022): 196. http://dx.doi.org/10.3390/gels8030196.

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In this study, we report the highly responsive chitosan-based chemically cross-linked nanomatrices, a nano-version of hydrogels developed through modified polymerization reaction for solubility improvement of poorly soluble drug simvastatin. The developed nanomatrices were characterized for solubilization efficiency, swelling studies, sol-gel analysis, in vitro drug release studies, DSC, FTIR, XRD, SEM, particle size analysis, and stability studies. An in vivo acute toxicity study was conducted on female Winstor rats, the result of which endorsed the safety and biocompatibility of the system.
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15

Khan, Hafeez Ullah, Fahmeed Nasir, Safirah Maheen, et al. "Antibacterial and Wound-Healing Activities of Statistically Optimized Nitrofurazone- and Lidocaine-Loaded Silica Microspheres by the Box–Behnken Design." Molecules 27, no. 8 (2022): 2532. http://dx.doi.org/10.3390/molecules27082532.

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In the current study, nitrofurazone- (NFZ) and lidocaine-loaded (LD) silica microspheres were fabricated to address pathological indications of skin infections. The microspheres were prepared by the sol–gel method applying the Box–Behnken design and evaluated for size distribution, morphology, zeta potential, physico-chemical compatibility, XRD, thermogravimetric analysis, antibacterial and cytotoxicity activities. The comparative in vitro drug release study of microspheres revealed a 30% release of NFZ and 33% of LD after 8 h. The microspheres showed 81% percentage yield (PY) and 71.9% entrap
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Eze, Fredrick Nwude, Chaweewan Jansakul, and Teerapol Srichana. "Insights into the formulation properties, biocompatibility, and permeability of poorly water-soluble methoxyflavones with PEG400 and propylene glycol." Acta Pharmaceutica 73, no. 3 (2023): 385–404. http://dx.doi.org/10.2478/acph-2023-0030.

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Abstract Herein, thermal and non-thermal techniques were used to elucidate the putative physical and chemical interactions between poorly water-soluble Kaempferia methoxyflavones and PEG400/propylene glycol. Additionally, the biocompatibility of methoxyflavone-glycol solutions was evaluated using Caco-2 cells whereas the absorptive transport was investigated by measuring the apparent permeability coefficient (P app) of the methoxyflavones and transepithelial electrical resistance (TEER) of the Caco-2 cell monolayer. Data from differential scanning calorimetry, Fourier-transform infrared (FTIR)
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17

Kota, Ravi Kumar, and Suresh Gande. "Development and Evaluation of Olmesartan Medoxomil Controlled Release Floating Microspheres using Natural Gums." International Journal of Pharmaceutical Sciences and Nanotechnology 10, no. 4 (2017): 3788–94. http://dx.doi.org/10.37285/ijpsn.2017.10.4.6.

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The present research was aimed to prepare Olmesartan medoxomil floating microspheres for controlled release using polymers such as sodium alginate, sodium bicarbonate, calcium chloride, Hydroxy propyl methyl cellulose (HPMC K4M, K15M), Olibanum gum and Xanthan gum by ionotropic gelation method. The prepared microspheres were evaluated for the percent drug content, entrapment efficiency, percentage buoyancy and in vitro dissolution studies. Among all the formulations F14 was selected as optimized formulation based on the micromeretic and physico-chemical parameters including drug release studie
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18

T.Ismail, Sara, Myasar M. Al-Kotaji, and Ahlam A. Khayrallah. "Formulation and Evaluation of Nystatin Microparticles as a Sustained Release System." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 24, no. 2 (2017): 1–10. http://dx.doi.org/10.31351/vol24iss2pp1-10.

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Nystatin is the drug of choice for treatment of cutaneous fungal infections with main disadvantage that is the need for multiple applications to achieve complete eradication which may reduce patient compliance. Microparticles offer a solution for such issue as they are one of sustained release preparations that achieve slow release of drug over an extended period of time. The objectives of this study were to fabricate nystatin-loaded chitosan microparticles with the ultimate goal of prolonging drug release and to analyze the influence of polymer concentration on various properties of micropart
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Alvi, Zunaira, Muhammad Akhtar, Nisar U. Rahman, et al. "Utilization of Gelling Polymer to Formulate Nanoparticles Loaded with Epalrestat-Cyclodextrin Inclusion Complex: Formulation, Characterization, In-Silico Modelling and In-Vivo Toxicity Evaluation." Polymers 13, no. 24 (2021): 4350. http://dx.doi.org/10.3390/polym13244350.

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Epalrestat (EPL) is an aldose reductase inhibitor with poor aqueous solubility that affects its therapeutic efficacy. The research study was designed to prepare epalrestat-cyclodextrins (EPL-CDs) inclusion complexes to enhance the aqueous solubility by using beta-cyclodextrin (β-CD) and sulfobutyl ether₇ β-CD (SBE7 β-CD). Furthermore, polymeric nanoparticles (PNPs) of EPL-CDs were developed using chitosan (CS) and sodium tripolyphosphate (sTPP). The EPL-CDs complexed formulations were then loaded into chitosan nanoparticles (CS NPs) and further characterized for different physico-chemical prop
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20

Vaishnavi, Bandari, G. Tarun Reddy, Akash Bansal, Deva Likitha, Deeksha Charagondla, and D. Prasanthi. "Solubility Enhancement of Efinaconazole using Neem Gum and Evaluation of Antifungal Activity." Indian Journal Of Science And Technology 17, no. 17 (2024): 1735–44. http://dx.doi.org/10.17485/ijst/v17i17.311.

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Objectives: Efinaconazole is an anti-fungal drug of BCS class II used for treating Onchomycosis. Neem gum known for its antifungal properties was purified and used as hydrophilic carrier. Solid dispersions by physical mixture and solvent evaporation method were prepared using purified Neem gum. Methods: The prepared solid dispersions in ratios 1:1, 1:3 and 1:6 were characterized for percentage yield, assay, solubility, and dissolution studies. The optimized solid dispersion SD6 was formulated as gel for ease of application. Gels were characterized for physico-chemical properties and in-vitro d
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Jumat, Mohamad Amin, Nor Syahiran Zahidin, Mohd Amirul Aizat Zaini, Nurul Afiqah Fadzil, Hadi Nur, and Syafiqah Saidin. "INCORPORATION OF ACALYPHA INDICA EXTRACT IN POLYVINYL ALCOHOL HYDROGELS: PHYSICO-CHEMICAL, ANTIBACTERIAL AND CELL COMPATIBILITY ANALYSES." Jurnal Teknologi 83, no. 2 (2021): 57–65. http://dx.doi.org/10.11113/jurnalteknologi.v83.14763.

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Acalypha indica (A. indica) possesses antibacterial properties and has capability to accelerate wound healing due to its active therapeutic compounds of flavonoid and alkaloid. The incorporation of A. indica extracts in polymer hydrogels is useful for wound treatment, despite the advancement in synthetic medicines and drugs. In this study, polyvinyl alcohol (PVA) hydrogels with different concentrations of A. indica extract (0.5, 1.0, 1.5 and 2.0 mg) were fabricated. The ATR-FTIR spectra testified the presence of A. indica in the hydrogels. More enormous spotted agglomerations were visualized o
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Semberova, Jana, Karel Holada, Olga Simakova, Monique P. Gelderman-Fuhrmann, and Jan Simak. "Carbon Nanotubes Activate Platelets by Facilitating Extracellular Ca2+ Influx." Blood 112, no. 11 (2008): 992. http://dx.doi.org/10.1182/blood.v112.11.992.992.

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Abstract Due to a unique combination of their physico-chemical properties, carbon nanotubes (CNTs) are among the principal materials used in biomedical nanotechnologies. Superior mechanical characteristics like elasticity (CNTs 1012Pa vs. steel 108Pa) and tensile strength (CNTs 100 GPa vs. steel 2 GPa) make CNTs very attractive candidates as materials for plastic composites for various biomedical applications including devices for collection, processing, and storage of blood transfusion products. Moreover, CNTs have a profound impact on the development of diagnostic biosensors, drug delivery n
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Babu, Gorantla Naresh, Menaka Muthukarupan, Hindustan Abdul Ahad, and Veerabomma Sreedhar. "Fabrication and Preliminary Assessment of Neem Fruit Mucilage as Mucoadhesive Abetting Assets with Methpol-934P for Acyclovir Delivery from Mucoadhesive Microcapsules." Biomedical and Pharmacology Journal 15, no. 4 (2022): 2179–84. http://dx.doi.org/10.13005/bpj/2554.

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In this study, we investigated the mucoadhesive properties of neem fruit mucilage by incorporating it into mucoadhesive microcapsules with Acyclovir (ACR). Methpol-934P and Neem fruit mucilage (NFM) was used to construct 12 different mucoadhesive microcapsules. We assessed FTIR and DSC capabilities for compatibility with ACR and NFM. ACR mucoadhesive microcapsules (ANMM) were characterized for mucoadhesion and ACR release Physico-chemical characteristics. CR was found to be compatible with NFM in the research. The entrapment increased as the levels of NFM in the formulations increased, and muc
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Ashwin, Kancham, Tummuluru R. Reddy, and Puttaswamy Nirmala. "Preparation and Evaluation of Extended Release Trilayered Matrix Tablets of Ramipril Using Design of Experiment." International Journal of Pharmaceutical Sciences and Drug Research 13, no. 06 (2020): 629–37. http://dx.doi.org/10.25004/ijpsdr.2021.130605.

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The current work is aimed to design, prepare, and evaluate the trilayer matrix tablets incorporated with ramipril for extended drug release. Twenty-seven formulations (RF1-RF27) for active layer (middle layer) were prepared by direct compression method using 33 Response surface method of polymers of different HPMC K4M, HPMC K15M and xanthan gum (low, middle, and high concentrations) by using Design of experiment software. Based on physico-chemical properties and drug release one formulation was chosen and formulated into extended release trilayered matrix tablets were by varying proportions of
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D’Huart, Elise, Pauline Lider, Jean Vigneron, and Béatrice Demoré. "Evolution of the Stabilis® Database: Creation of a Level of Evidence for Stability Studies." Pharmaceutical Technology in Hospital Pharmacy 3, no. 1 (2018): 3–12. http://dx.doi.org/10.1515/pthp-2018-0002.

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AbstractBackgroundStabilis®is an international database on stability and compatibility of drugs. The stability data comes mainly from publications of pharmaceutical journals. As the quality of the published stability studies is not equivalent, the objective of this work was to propose a level of evidence for the physico-chemical stability studies selected for the database.MethodsAt first, we evaluated the main pharmacological class consulted by the users. This work was then divided into 5 steps: (1) updating of the criteria to validate a stability study, (2) creating a grid rating articles, (3
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Nadendla, Rama Rao, Prachet Pinnamaneni, Siva Prasad Morla, and Patchala Abhinandana. "Physico-Chemical Characterization of Paliperidone Palmitate and Compatibility Studies with its Pharmaceutical Excipients." Journal of Pharmaceutical Research International, March 1, 2021, 85–91. http://dx.doi.org/10.9734/jpri/2021/v33i531183.

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Aim: The main aim of the present study was to characterize and perform the compatibility studies of paliperidone with its excipients.
 Study Design: Physico-chemical characterization and compatibility studies.
 Place and Duration of the Study: Chalapathi Drug Testing Laboratory, Chalapathi Institute of Pharmaceutical Sciences, Chalapathi Nagar, Lam, Guntur-522034 between December 2020 and January 2021.
 Methodology: Physico-chemical characterization and compatibility studies of paliperidone palmitate with its excipients like HPMC, lactose, magnesium stearate, talc, microcrystall
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Nadendla, Rama rao, Satyanarayana Juluri, Sai shanmukh srinivas Doppalapudi, et al. "Physico-Chemical Characterization of Rivaroxaban and Compatibility Studies with Its Pharmaceutical Excipients." International Journal of Life Science and Pharma Research, May 1, 2021, P25—P32. http://dx.doi.org/10.22376/ijpbs/lpr.2021.11.3.p25-p32.

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Physico-chemical compatibility studies were performed to check the effect of different excipients on API and it is the prerequisite in the preformulation studies. The main aim of this research is to study the behavior of the API individually and with the selected pharmaceutical excipients which mainly contribute in the selection of suitable excipients for developing an ideal dosage form. Rivaroxaban is an oral anticoagulant that mainly acts by blocking coagulant factor Xa. Incompatibility studies were performed for rivaroxaban with selected pharmaceutical excipients like HPMC, lactose, magnesi
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Patel, Dhaval J., Saurav M. Patel, Sanjesh G. Rathi, and Shrenik K. Shah. "Formulation and Evaluation of Transdermal Patch of Blonanserin." International Journal of Pharmaceutical Sciences Review and Research 69, no. 2 (2021). http://dx.doi.org/10.47583/ijpsrr.2021.v69i02.011.

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The objective of the present study was to formulate and evaluate transdermal patch of Blonanserin. Blonanserin transdermal patches were prepared by solvent casting method using natural and synthetic polymer. Various plastisizer were screened along with polymers. Drug excipient compatibility studies concluded that the drug and excipient are compatible with each other. The prepared patches were evaluated for physico-chemical parameters to justify their suitability for transdermal use. Formulations containing Xanthan Gum with plasticizer propylene glycol gives best drug release in 8 hours. More t
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Thi, Phuong Le, Thi Yen Nhi Tran, Hung Cuong Luu, Dieu Linh Tran, Thai Thanh Hoang Thi, and Dai Hai Nguyen. "In situ forming gelatin: Cyclodextrin hydrogels prepared by “click chemistry” to improve the sustained release of hydrophobic drugs." Journal of Bioactive and Compatible Polymers, June 7, 2022, 088391152210980. http://dx.doi.org/10.1177/08839115221098058.

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Injectable hydrogels offer a wide range of attractive benefits in drug delivery applications, such as non-invasive administration, easy drug incorporation and locally controlled release at the target sites. Herein, we designed a simple and efficient method to prepare injectable hydrogels composed of gelatin and cyclodextrin (CD) for high loading capacity of hydrophobic drugs. The hydrogels were formed by thiol-functionalized gelatin (GSH) and βCD-vinyl sulfone (βCD-VS) as cross-linker, via thiol-ene “click” chemistry. Hydrogels comprising of different cross-linker feed amount were investigated
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D, Prasanthi, PRASHANTI S, and MEGHANA G. "FORMULATION AND EVALUATION OF PRESS COATED TABLETS OF LANSOPRAZOLE." International Journal of Applied Pharmaceutics, April 11, 2019, 49–56. http://dx.doi.org/10.22159/ijap.2019v11i4.32617.

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Objective: Lansoprazole an proton pump inhibitor, degrades in acidic environment, hence protection of drug is done by coating the drug with enteric coating polymers. The aim and objective of the present study was to prepare enteric coated delayed release tablets of lansoprazole by using press coating technique.
 Methods: Core tablets were prepared by direct compression and evaluated for their physico-chemical properties. Press coated tablets were formulated by using different combinations of ethyl cellulose, HPMC E15 and HPMC K4M as a coating layer. Core and coated tablets were optimized
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Hecq, Jean-Daniel, Benoit Bihin, Jacques Jamart, and Laurence Galanti. "Criteria for Judging the Quality of a Publication on Physicochemical Stability of Ready to Use Injectable Drugs." Pharmaceutical Technology in Hospital Pharmacy 2, no. 2 (2017). http://dx.doi.org/10.1515/pthp-2017-0012.

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AbstractIn hospitals, a major part of the drugs is administered via the intravenous route. When one wants to evaluate or know the stability of a drug in solution, it is necessary to know several physico-chemical parameters. Several reference works are available to help the hospital pharmacist with this research. However, reading these different sources can make you discover conflicting data. It is therefore necessary at this time to obtain the publications with contradictory results and to read them again. Seven criteria have been identified for judging the quality of a publication on physicoc
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Chawla, Ruchi, Venkatanaidu Karri, Varsha Rani, Mohini Mishra, and Krishan Kumar. "Factorial Design-Based Nanocarrier Mediated Formulation of Efavirenz and Its Characterization." Nano LIFE, February 25, 2022. http://dx.doi.org/10.1142/s1793984422500027.

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Efavirenz (EFV) suffers from poor aqueous solubility which results in low bioavailability of the drug. Nanocarrier-based drug delivery systems offer a suitable alternative for improving the physico-chemical properties of the drug and hence its efficacy. Nanosuspension (NS) of EFV was formulated by solvent-anti solvent precipitation method using PVP K-30 as stabilizer and sodium lauryl sulphate (SLS) as the wetting agent. Multi-level factorial design was applied to select the optimal formulation which was further characterized. The optimal batch exhibited mean particle size of 305[Formula: see
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Patel, Chirag Karshanbhai, Disha Suthar, Hetal Patel, Vinit Movaliya, and Punit Parejiya. "Assessment of suitability of saxagliptin hydrochloride for development of controlled release parenteral formulation by preformulation studies." International journal of health sciences, April 21, 2022, 3223–36. http://dx.doi.org/10.53730/ijhs.v6ns3.6336.

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The main objective of pre-formulation study is to develop the stable, elegant, safe and effective drug delivery system by establishing drug kinetic profile, formulation compatibility with different excipients and physico-chemical parameters of new drug molecules. This could provide key evidence for implementing formulation design or requirement of the molecular alteration. So, in the present study preformulation studies were performed on Saxagliptin Hydrochloride (SXG) to assess its suitability for parenteral formulation. SXG is a potent and selective reversible inhibitor of dipeptidyl peptida
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Sinézia, Celimar, Tháyna Sisnande, Luis Peña Icart, and Luís Maurício T. R. Lima. "Oral delivery of the amylin receptor agonist pramlintide." Peptide Science, January 31, 2024. http://dx.doi.org/10.1002/pep2.24346.

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AbstractAmylin receptor agonism safely benefit diabetic patients, reducing the insulin requirements and glycemic excursions. Pramlintide is the triple proline human amylin analogue first used as injectable drug, but lacking physico‐chemical compatibility when co‐formulated with insulin. Here, we report the design and characterization of polymeric microparticles for oral delivery of pramlintide. Eudragit S100, a gastric‐resistant polymer, was used in preparation of pramlintide‐loaded spherical microcapsules by double emulsion and solvent evaporation technique, with approximately 66 μm ± 11 part
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35

Wadaskar, Pallavi, Pallavi Kharkar, and Pallavi Ispade. "Preparation and Evaluation of Yohimbine Hydrochloride Agglomerates by Crystallo Co-Agglomeration technique." Research Journal of Pharmaceutical Dosage Forms and Technology, April 30, 2022, 105–10. http://dx.doi.org/10.52711/0975-4377.2022.00016.

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Crystallo-co-agglomeration (CCA) is an innovative technique developed with the intention to produce the drugs with good micromeritic and mechanical characteristics. Yohimbine Hydrochlorideis an anti-retroviral drug with poor dissolution and poor flow properties. Hence the aim of the study is to prepare the crystallo co-agglomerates of Yohimbine Hydrochloridewhich may improve the properties of Yohimbine Hydrochloride.The present study was carried out in order to develop pharmaceutically equivalent, stable, and quality improved agglomerates of Yohimbine Hydrochloridewith enhanced solubility wett
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Namdev, Nidhi, Mousumi Kar Pillai, Sujit Pillai Pillai, Ruchita Raghuvanshi, Ujjawal Ahirwal, and R. Yadav. "POLYSACCHARIDE BASED CONTROLLED RELEASE MUCOADHESIVE DRUG DELIVERY SYSTEM FOR PAIN MANAGEMENT." International Journal of Pharmaceutical Sciences and Drug Research, March 30, 2024, 206–12. http://dx.doi.org/10.25004/ijpsdr.2024.160210.

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Mucoadhesion is one of the most extensively studied methods for the administration of medication for faster onset of action with enhanced bioavailability. Present investigation was concerned with the development and characterization of controlled release muco-adhesive drug delivery system for the drug Tramadol Hydrochloride (TRD) to extend the duration of analgesia for patients suffering from acute to chronic pain. Formulations were made using the solvent casting technique, incorporating natural polymers like Guar Gum, Xanthum Gum and Chitosan in conjunction with HPMC (hydroxy propyl methyl ce
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Patel, Chirag, Disha Suthar, Hetal Patel, Vinit Movaliya, and Punit Parejiya. "Preformulation Study of Glimepiride: An Insight for Formulation and Development of Parenteral Formulation." Journal of Pharmaceutical Research International, February 25, 2022, 38–49. http://dx.doi.org/10.9734/jpri/2022/v34i15b35718.

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Aim: The objective of preformulation study is to develop the elegant, stable, effective and safe dosage form by establishing kinetic profile, compatibility with other formulation excipients and physico-chemical parameters of new drug substance. This could provide important information for formulation design or support the need for molecular modification. So, in the present study preformulation studies were performed on Glimepiride (GMP) to assess its suitability for parenteral formulation. Glimepiride is the first IIIrd generation sulphonyl urea used to treat type –II diabetes mellitus.
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Rajesh Pavan, Ampapuram, R. V. D. Praveen, Gorantla Naresh Babu, P. Ramakrishna Reddy, and G. Thirumala Roopesh. "Formulation Development and Evaluation of Desloratadine Sugar Free Oral Liquid Dosage Form." Research Journal of Pharmacy and Technology, December 24, 2022, 5425–30. http://dx.doi.org/10.52711/0974-360x.2022.00914.

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The aim of the present work is to formulate and evaluate Desloratadine Sugar free oral liquid dosage form. Desloratadine is an anti-histamine drug which is used to treat allergic reactions such as chronic utricaria, watery eyes and runny nose. In this Present work Desloratadine sugar free oral liquid dosage form was formulated by using artificial sweeteners with the help of simple mixing technique and subjected to various evaluation tests. The Pre-formulation studies like identification of pure drug by melting point method, solubility, Drug-Excipients compatibility studies by FTIR studies were
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39

Firdous, Zohra, Pankaj Dhapake, Nitin Padole, Nilakshi Dhoble, and Jagdish Baheti. "Different Approaches for Transdermal Nano-Carrier Delivery System." Research Journal of Topical and Cosmetic Sciences, November 28, 2023, 94–104. http://dx.doi.org/10.52711/2321-5844.2023.00015.

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Transdermal drug delivery is a validated technology that makes a significant contribution to global pharmaceutical care. Since 1980, the sector has seen impressive growth with several commercial successes. The term transdermal drug delivery refers to the delivery of a drug across the layers of skin with the intention of allowing the drug to be absorbed through the skin in a predetermined and controlled rate manner. Skin is one of the largest organs that act as an efficient barrier for drug delivery. The present study focuses on the different approaches of nano-carrier system that delivers the
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40

Lalan, Manisha, Divya Patel, Maanika Menon, Pranav Shah, and Meenakshi Patel. "Application Of D-Optimal Mixture Design In The Development Of Nanocarrier-Based Darifenacin Hydrobromide Gel." Recent Advances in Drug Delivery and Formulation 17 (February 21, 2023). http://dx.doi.org/10.2174/2667387817666230221141501.

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Background: Darifenacin hydrobromide, a BCS Class II drug, is poorly bioavailable due to extensive first-pass metabolism. The present study is an attempt to investigate an alternative route of drug delivery by developing a nanometric microemulsion-based transdermal gel for the management of an overactive bladder. Method: Oil, surfactant, and cosurfactant were selected based on the solubility of the drug, and surfactant: cosurfactant in surfactant mixture (Smix) was selected at a 1:1 ratio as inferred from the pseudo ternary phase diagram. The D-optimal mixture design was used to optimize the o
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41

Prasanthi, D., Shreya Ajay Rajguru, C. Aishwarya, and Aisha Rahman. "Pulsatile Delivery of Fexofenadine Hydrochloride Pulsincap by Box-Behnken Design." Journal of Pharmaceutical Research International, December 16, 2021, 649–63. http://dx.doi.org/10.9734/jpri/2021/v33i59a34316.

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Objective: Fexofenadine hydrochloride is a selective peripheral H1-blocker, used for allergy symptoms, such as hay fever and urticaria. Allergic symptoms are aggressive during early morning hours, so a pulsatile delivery system with a lag time of 4-5 hours was formulated and optimized by Box-Behnken design.
 Materials and Methods: Pulsincap system using formaldehyde-treated capsules and hydrogel plug. Box-Behnken design was applied for optimization in which three independent variables, X1= Drug: polymer ratio, X2 = Polymer: polymer ratio (Ethylcellulose: HPMC E15) and X3 = Plug weight wer
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42

Sharma, Shushank. "An overview of Natural Superdisintegrants." Research Journal of Topical and Cosmetic Sciences, December 22, 2021, 113–24. http://dx.doi.org/10.52711/2321-5844.2021.00016.

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The oral route is the most convenient route of administration for various drugs. It is viewed as the most convenient, most secure, and economical route for patients. Fast disintegrating tablets are popular these days as they disintegrate in the mouth within a few seconds without the use of water. The burdens of regularly used medications in pediatric and geriatric patients have been overwhelmed by quick-dissolving tablets. Natural superdisintegrants have been used for fast-dissolving tablets because they are biodegradable, chemically inert, non-harmful, more affordable, and generally accessibl
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Sharma, Shushank, and Sikha Chauhan. "A review: An overview of Natural Superdisintegrants." Research Journal of Topical and Cosmetic Sciences, May 17, 2021, 13–24. http://dx.doi.org/10.52711/2321-5844.2021.00003.

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The oral route is the most convenient route of administration for various drugs. It is viewed as the most convenient, most secure, and economical route for patients. Fast disintegrating tablets are popular these days as they disintegrate in the mouth within a few seconds without the use of water. The burdens of regularly used medications in pediatric and geriatric patients have been overwhelmed by quick-dissolving tablets. Natural superdisintegrants have been used for fast-dissolving tablets because they are biodegradable, chemically inert, non-harmful, more affordable, and generally accessibl
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44

Rajyam, R. Lakshmi, M. Keerthana, D. V. Sowmya, and M. Vidyavathi. "Extraction and Evaluation of Musa paradisiaca Stem Mucilage as a Pharmaceutical Excipient." Journal of Pharmaceutical Research International, December 30, 2021, 566–80. http://dx.doi.org/10.9734/jpri/2021/v33i64a36133.

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Aim: In present Pharmaceutical trend, natural excipients are gaining more importance because of their availability, safety, performance, and cost. The present work aimed at extraction of the mucilage from the stem of Musa paradisiaca (banana) and evaluation of extracted mucilage for its binding and disintegrating properties with Paracetamol as a model drug.
 Methodology: The mucilage was extracted by aqueous extraction method followed by precipitation and evaluated for various physico-chemical properties. Drug-mucilage compatibility studies were conducted by FT-IR spectrometer. The extrac
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45

Rajyam, R. Lakshmi, M. Keerthana, D. V. Sowmya, and M. Vidyavathi. "Extraction and Evaluation of Musa paradisiaca Stem Mucilage as a Pharmaceutical Excipient." Journal of Pharmaceutical Research International, December 30, 2021, 566–80. http://dx.doi.org/10.9734/jpri/2021/v33i64a36133.

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Aim: In present Pharmaceutical trend, natural excipients are gaining more importance because of their availability, safety, performance, and cost. The present work aimed at extraction of the mucilage from the stem of Musa paradisiaca (banana) and evaluation of extracted mucilage for its binding and disintegrating properties with Paracetamol as a model drug.
 Methodology: The mucilage was extracted by aqueous extraction method followed by precipitation and evaluated for various physico-chemical properties. Drug-mucilage compatibility studies were conducted by FT-IR spectrometer. The extrac
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46

Khan, Hafeez Ullah, Samar Aziz, Safirah Maheen, et al. "Superporous acrylic acid and HPMC hydrogels of mefenamic acid: Formulation, characterization and optimization by central composite design." Frontiers in Bioengineering and Biotechnology 10 (December 15, 2022). http://dx.doi.org/10.3389/fbioe.2022.1057627.

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The purpose of the study was to devise the superporous hydrogels (SPHs) of mefenamic acid (MA) to acquire the sustained action of the MA in the body. The superporous hydrogels of mefenamic acid were formulated by employing the gas blowing method. The central composite rotatable design (CCRD) was applied to optimize the effect of independent formulation factors like acrylic acid (AC), HPMC and glycerol (GLY) over dependent variables like porosity, viscosity, drug content and swelling ratio of superporous hydrogels in water, phosphate buffer (pH 6.8) and in 0.1N HCl (pH 1.2). A number of charact
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Damato, Anna, Fabio Vianello, Enrico Novelli, et al. "Comprehensive Review on the Interactions of Clay Minerals With Animal Physiology and Production." Frontiers in Veterinary Science 9 (May 10, 2022). http://dx.doi.org/10.3389/fvets.2022.889612.

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Clay minerals are naturally occurring rock and soil materials primarily composed of fine-grained aluminosilicate minerals, characterized by high hygroscopicity. In animal production, clays are often mixed with feed and, due to their high binding capacity towards organic molecules, used to limit animal absorption of feed contaminants, such as mycotoxins and other toxicants. Binding capacity of clays is not specific and these minerals can form complexes with different compounds, such as nutrients and pharmaceuticals, thus possibly affecting the intestinal absorption of important substances. Inde
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